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Surgical Infections

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https://www.readbyqxmd.com/read/29791301/the-significance-of-interleukin-6-in-the-early-detection-of-surgical-site-infections-after-definitive-operation-for-gastrointestinal-fistulae
#1
Dongming Zhang, Jianan Ren, Mohamed-Omar Arafeh, Robert G Sawyer, Qiongyuan Hu, Xiuwen Wu, Gefei Wang, Guosheng Gu, Jiang Hu, Mingzhang Li
BACKGROUND: Surgical site infections (SSIs) are among the most common complications after definitive treatment for intestinal fistulae. Serum inflammatory markers including white blood cell count (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), as well as procalcitonin (PCT) have been used to help diagnosis post-operative complications. OBJECTIVE: The goal of this study was to assess the clinical value of inflammatory markers, specifically IL-6, in predicting SSIs after intestinal fistulae resection...
May 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29791270/potential-for-spread-of-hand-infection-after-elastic-exsanguination
#2
Scott Farner, Laxminarayan Bhandari, David Tate
No abstract text is available yet for this article.
May 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29781787/evaluating-the-duration-of-prophylactic-post-operative-antibiotic-agents-after-open-reduction-internal-fixation-for-closed-fractures
#3
Brett D Crist, Lasun O Oladeji, Gregory J Della Rocca, David A Volgas, James P Stannard, David D Greenberg
BACKGROUND: The importance of timely pre-operative antibiotic agents for effective surgical prophylaxis has been established but the optimal duration of antimicrobial coverage post-operatively has not yet been defined clearly. The purpose of this study was to determine if prophylactic post- operative cefazolin for 23 hours decreases the risk of surgical site infection (SSI) after open reduction internal fixation (ORIF) of closed extremity fractures. PATIENTS AND METHODS: After Institutional Reviews Board approval, patients undergoing ORIF of closed extremity fractures who had a planned post-operative stay of at least 23 hours were randomly assigned to either receive 23 hours of cefazolin or a placebo...
May 21, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29775554/outcomes-and-predictors-of-early-infection-after-heart-transplantation
#4
Kendall C Shultes, Jerrica E Shuster, Scott Micek, Justin M Vader, Keki Balsara, Akinobu Itoh, Bethany R Tellor
BACKGROUND: Limited data exist on the incidence and outcome of early infection after orthotopic heart transplantation (OHT). The purpose of this study was to describe characteristics and outcomes of OHT recipients with an early infection and to identify predictors of such infections. METHODS: This retrospective, single-center study included patients greater than 18 years of age who underwent OHT from February 2009 to May 2014 and had an infection within 30 days of transplantation...
May 18, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29750599/peri-operative-nasal-eradication-therapy-prevents-staphylococcus-aureus-surgical-site-infections-in-aortoiliac-surgery
#5
Jasper C M Langenberg, Jan A J W Kluytmans, Paul G H Mulder, Jannie Romme, Gwan H Ho, Lyckle Van Der Laan
BACKGROUND: Surgical site infections (SSIs) cause considerable morbidity and deaths among patients undergoing vascular surgery. Pre-operative screening and subsequent treatment of nasal Staphylococcus aureus carriers with mupirocin and chlorhexidine reduces the risk of SSIs in cardiothoracic and orthopedic surgery. The aim of this study was to investigate the effect of this screen-and-treat strategy on the development of SSI in patients undergoing aortoiliac surgery. METHODS: A prospective study was performed that enrolled an intervention cohort comprising all patients undergoing aortoiliac surgery from February 2013 to December 2016...
May 11, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29727259/sepsis-screening-tools-in-the-era-of-sepsis-3-0
#6
Xianshi Zhou, Ye Ye, Guanghua Tang
No abstract text is available yet for this article.
May 4, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29717917/higher-versus-lower-dose-of-cefotetan-or-cefoxitin-for-surgical-prophylaxis-in-patients-weighing-one-hundred-twenty-kilograms-or-more
#7
Mary Banoub, Melanie S Curless, Janessa M Smith, Andrew S Jarrell, Sara E Cosgrove, Clare Rock, Edina Avdic
BACKGROUND: Clinical practice guidelines recommend a 2-g dose of cefotetan and cefoxitin for surgical prophylaxis. Pharmacokinetic data suggest benefit from higher cefotetan and cefoxitin dosing in obese patients. However, clinical studies examining higher dosing strategies in this at-risk population are lacking. The purpose of this study was to determine whether 3 g of cefotetan or cefoxitin administered pre-operatively for patients who weigh 120 kg or more is associated with a lower proportion of surgical site infection (SSI) compared with 2 g...
May 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29717911/epidemiology-of-trauma-related-infections-among-a-combat-casualty-cohort-after-initial-hospitalization-the-trauma-infectious-disease-outcomes-study
#8
David R Tribble, Margot R Krauss, Clinton K Murray, Tyler E Warkentien, Bradley A Lloyd, Anuradha Ganesan, Lauren Greenberg, Jiahong Xu, Ping Li, M Leigh Carson, William Bradley, Amy C Weintrob
BACKGROUND: The Trauma Infectious Disease Outcomes Study (TIDOS) cohort follows military personnel with deployment-related injuries in order to evaluate short- and long-term infectious complications. High rates of infectious complications have been observed in more than 30% of injured patients during initial hospitalization. We present data on infectious complications related to combat trauma after the initial period of hospitalization. PATIENTS AND METHODS: Data related to patient care for military personnel injured during combat operations between June 2009 and May 2012 were collected...
May 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29717907/cephalosporin-plus-metronidazole-for-surgical-prophylaxis
#9
E Patchen Dellinger
No abstract text is available yet for this article.
May 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29708848/clostridium-difficile-infection-in-trauma-surgery-and-medical-patients-admitted-to-the-intensive-care-unit
#10
Richard R Watkins, Caroline Mangira, Farid Muakkassa, Curtis J Donskey, Nairmeen A Haller
BACKGROUND: Clostridium difficile infection (CDI) causes significant morbidity and mortality rates, especially for patients in the intensive care unit (ICU). Data comparing trauma and surgery patients with CDI in the ICU with medical patients with CDI in the ICU are limited. METHODS: In a single-center study, we analyzed retrospective data from 25 trauma patients and 13 surgery patients aged 18 years or older who had CDI and had been admitted to the ICU. A comparison group of 156 medical patients aged 18 years or greater who had CDI and were admitted to the ICU also was identified...
April 30, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29688837/use-and-effectiveness-of-peri-operative-cefotetan-versus-cefazolin-plus-metronidazole-for-prevention-of-surgical-site-infection-in-abdominal-surgery-patients
#11
Eleanor Danan, Janessa Smith, Rachel M Kruer, Edina Avdic, Pamela Lipsett, Melanie S Curless, Andrew S Jarrell
BACKGROUND: Current practice guidelines for antimicrobial prophylaxis in surgery recommend a cephamycin or cefazolin plus metronidazole for various abdominal surgeries. In February 2016, cephamycin drug shortages resulted in a change in The Johns Hopkins Hospital's (JHH) recommendation for peri-operative antibiotic prophylaxis in abdominal surgeries from cefotetan to cefazolin plus metronidazole. The primary objective of this study was to quantify the percentage of abdominal surgeries adherent to JHH peri-operative antibiotic prophylaxis guidelines...
April 24, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29683405/longitudinal-evaluation-of-plasma-concentrations-of-presepsin-in-patients-after-severe-trauma-a-prospective-observational-study
#12
Christian Koch, Sophie Ruhrmann, Michael Pöhlmann, Emmanuel Schneck, Borros Arneth, Thomas Zajonz, Michael Sander, Markus A Weigand, Florian Uhle
BACKGROUND: The high mortality rate of patients suffering from severe trauma is based not only on the mechanism of injury, but also on the higher risk for development of subsequent infections. Therefore, the early recognition of infection after severe trauma is of particular importance for patient outcome. However, early diagnosis is often masked by the consequences of the sterile, damage-triggered immune response. Our study sought to analyze the course of soluble CD14-subtype (sCD14-ST, presepsin) compared with clinically established inflammatory and infectious biomarkers in a cohort of patients with severe trauma...
April 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29672240/national-survey-of-operating-room-nurses-aseptic-techniques-and-interventions-for-patient-preparation-to-reduce-surgical-site-infections
#13
Camilla Wistrand, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: Surgical site infection (SSI), the third most common type of nosocomial infection in Sweden, is a patient injury that should be prevented. Methods of reducing SSIs include, for instance, disinfecting the skin, maintaining body temperature, and ensuring an aseptic environment. Guidelines for most of these interventions exist, but there is a lack of studies describing to what extent the preventive interventions have been implemented in clinical practice. We describe the daily clinical interventions Swedish operating room (OR) nurses performed to prevent SSIs following national guidelines...
April 19, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29630451/surgical-site-and-graft-infections-in-endovascular-and-open-abdominal-aortic-aneurysm-surgery
#14
Jasper C M Langenberg, Jan A J W Kluytmans, Hans G W de Groot, Gwan H Ho, Eelco J Veen, M G Buimer, Lijckle van der Laan
BACKGROUND: Surgical site infections (SSIs) constitute one of many major complications after aortic aneurysm surgery and its details and outcome have not been evaluated extensively. This research evaluates the incidence and outcome of SSI and graft infection in open and endovascular abdominal aortic aneurysm surgery. PATIENTS AND METHODS: A retrospective study was performed, including all patients who underwent surgery for aortoiliac aneurysmatic disease between January 2000 and December 2016 in the Amphia Hospital, Breda, The Netherlands...
April 9, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29624485/microbial-glucuronidase-inhibition-reduces-severity-of-diclofenac-induced-anastomotic-leak-in-rats
#15
Simon T K Yauw, Melissa Arron, Roger M L M Lomme, Petra van den Broek, Rick Greupink, Aadra P Bhatt, Matthew R Redinbo, Harry van Goor
BACKGROUND: The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is unclear. Previous data suggest that reactivation of biliary diclofenac metabolites by microbial β-glucuronidases in the gut plays a role in harming the intestinal mucosa, and that microbiome-targeted glucuronidase inhibition prevents this damage. Here, the microbial glucuronidase inhibitor Inh1 was examined for its ability to reduce diclofenac-induced anastomotic leakage in rats...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29624484/early-inflammatory-biomarkers-as-predictive-factors-for-freedom-from-infection-after-colorectal-cancer-surgery-a-prospective-cohort-study
#16
André Goulart, Carla Ferreira, Alexandra Estrada, Fernanda Nogueira, Sandra Martins, António Mesquita-Rodrigues, Nuno Sousa, Pedro Leão
PURPOSE: Different biomarkers are useful in diagnosing infections. The aim of this work was to clarify the relation between different inflammatory biomarkers (white blood cell [WBC] count, C-reactive protein [CRP], procalcitonin [PCT], and C-reactive protein-to-albumin ratio [CAR]) and early infectious complications after colorectal surgery. METHODS: This prospective single-center cohort study included 130 patients undergoing elective colorectal surgery. The WBC count, CRP, and PCT were measured at post-operative day one (POD1) and POD3 and albumin on POD3...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29624479/in-vivo-and-in-vitro-anti-bacterial-efficacy-of-absorbable-barbed-polydioxanone-monofilament-tissue-control-device-with-triclosan
#17
Shubhangi Bhende, Daniel Burkley, Jesse Nawrocki
BACKGROUND: This study evaluated the in vitro and in vivo anti-bacterial efficacy of STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Devices in comparison with standard absorbable polydioxanone devices lacking triclosan, utilizing challenges by gram-positive and gram-negative bacteria. METHODS: The STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device was tested for in vitro efficacy against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), S...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29621001/antibiotic-use-and-antimicrobial-resistance-of-surgical-patients-with-peritonitis-at-a-tertiary-referral-hospital-in-rwanda
#18
Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere, Rahel G Ghebre
BACKGROUND: There is growing recognition of the worsening problem of antibiotic resistance and the need for antibiotic stewardship in low-resource settings. The aim of this study was to describe antibiotic use and antimicrobial resistance in patients undergoing surgery for peritonitis at a Rwandan referral hospital. PATIENTS AND METHODS: All surgical patients with peritonitis at a Rwandan referral hospital were enrolled. Prospective data were collected on epidemiology, clinical features, interventions, and outcomes...
April 5, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29608437/intra-operative-inspired-fraction-of-oxygen-and-the-risk-of-surgical-site-infections-in-patients-with-type-1-surgical-incisions
#19
Brendan T Wanta, Kristine T Hanson, Joseph A Hyder, Thomas M Stewart, Timothy B Curry, Elie F Berbari, Elizabeth B Habermann, Daryl J Kor, Michael J Brown
BACKGROUND: Whether the fraction of inspired oxygen (FI O2 ) influences the risk of surgical site infection (SSI) is controversial. The World Health Organization and the World Federation of Societies of Anesthesiologists offer conflicting recommendations. In this study, we evaluate simultaneously three different definitions of FI O2 exposure and the risk of SSI in a large surgical population. PATIENTS AND METHODS: Patients with clean (type 1) surgical incisions who developed superficial and deep organ/space SSI within 30 days after surgery from January 2003 through December 2012 in five surgical specialties were matched to specialty-specific controls...
April 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29608422/a-systematic-review-of-pericolic-extraluminal-air-in-left-sided-acute-colonic-diverticulitis
#20
Stefan T van Dijk, Sabrina A N Doelare, Anna A W van Geloven, Marja A Boermeester
BACKGROUND: Although approximately 15% of all patients with acute colonic diverticulitis have pericolic extraluminal air found on computed tomography (CT), studies on the natural course and treatment of these patients are scarce. It is not clear whether these patients behave as mild uncomplicated diverticulitis or as severe diverticulitis needing more aggressive treatment. Consequently, there is no consensus about the treatment, guidelines do not discuss this group of patients, and physicians treat these patients based on their own experiences and opinion...
April 2, 2018: Surgical Infections
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