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Journal of Cardiovascular Magnetic Resonance

Yongning Shang, Xiaochun Zhang, Xiaoyue Zhou, Jian Wang
BACKGROUND: The extracellular volume (ECV), derived from cardiovascular magnetic resonance (CMR) T1 mapping, is a biomarker of the extracellular space in the myocardium. The hematocrit (HCT), measured from venipuncture, is required for ECV measurement. We test the clinic values of synthetic ECV, which is derived from the longitudinal relaxation of blood-based (T1blood ) synthetic hematocrit in 3 T CMR. METHODS: A total of 226 subjects with CMR T1 mapping and HCT measurement taken on the same day as the CMR were retrospectively enrolled and randomly split into derivation (n = 121) and validation (n = 105) groups, comprising healthy subjects (n = 45), type 2 diabetes mellitus (T2DM) patients (n = 60), hypertrophic cardiomyopathy (HCM) patients (n = 93), and 28 other patients...
August 9, 2018: Journal of Cardiovascular Magnetic Resonance
Clotilde Roy, Alisson Slimani, Christophe de Meester, Mihaela Amzulescu, Agnes Pasquet, David Vancraeynest, Christophe Beauloye, Jean-Louis Vanoverschelde, Bernhard L Gerber, Anne-Catherine Pouleur
BACKGROUND: Increased myocardial fibrosis may play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology. The study aim was to evaluate the presence, associations, and prognostic significance of diffuse fibrosis in HFpEF patients compared to age- and sex-matched controls. METHODS: We prospectively included 118 consecutive HFpEF patients. Diffuse myocardial fibrosis was estimated by extracellular volume (ECV) quantified by cardiovascular magnetic resonance with the modified Look-Locker inversion recovery sequence...
August 8, 2018: Journal of Cardiovascular Magnetic Resonance
Ali Serhal, Ioannis Koktzoglou, Pascale Aouad, James C Carr, Shivraman Giri, Omar Morcos, Robert R Edelman
BACKGROUND: Comparing cardiovascular magnetic resonance (CMR) angiography with computed tomography angiography (CTA), a major deficiency has been its inability to reliably image peripheral vascular calcifications that may impact the choice of interventional strategy and influence patient prognosis. Recently, MRI using a proton density-weighted, in-phase stack of stars (PDIP-SOS) technique has proved capable of detecting these calcifications. The goal of the present study was two-fold: (1) to determine whether magnetic field strength impacts the apparent size and conspicuity of ilio-femoral arterial calcifications; and (2) to determine whether the technique can be accurately applied to image aorto-iliac arterial calcifications...
August 6, 2018: Journal of Cardiovascular Magnetic Resonance
Anouk L M Eikendal, Michiel L Bots, Aisha Gohar, Esther Lutgens, Imo E Hoefer, Hester M den Ruijter, Tim Leiner
BACKGROUND: Although endothelial cell adhesion molecules (CAMs) are postulated to play a key role in early atherosclerosis, studies on endothelial CAMs are mainly pertained to middle-aged populations and populations with an unfavourable cardiovascular risk burden. Therefore, this study evaluated whether circulating endothelial CAMs are related to cardiovascular magnetic resonance imaging (CMR) derived indicators of arterial wall alterations in a random sample of young adults from the general population...
August 2, 2018: Journal of Cardiovascular Magnetic Resonance
Masafumi Nii, Masaki Ishida, Kaoru Dohi, Hiroaki Tanaka, Eiji Kondo, Masaaki Ito, Hajime Sakuma, Tomoaki Ikeda
BACKGROUND: Peripartum cardiomyopathy is a life-threatening condition that occurs during the peripartum period in previously healthy women. Cardiovascular magnetic resonance (CMR) T1 mapping permits sensitive detection of tissue edema and fibrosis, and it may be useful in identifying altered myocardial tissue characteristics in peripartum cardiomyopathy. However, left ventricular (LV) volumes and mass increase considerably even in normal pregnancy, and it is not known whether altered tissue characteristics can be found in normal pregnancy...
August 2, 2018: Journal of Cardiovascular Magnetic Resonance
Kihei Yoneyama, Bharath A Venkatesh, Colin O Wu, Nathan Mewton, Ola Gjesdal, Satoru Kishi, Robyn L McClelland, David A Bluemke, João A C Lima
BACKGROUND: Although diabetes mellitus (DM) and insulin resistance associate with adverse cardiac events, the associations of left ventricular (LV) remodeling and function with compromised glucose metabolism have not been fully evaluated in a general population. We used cardiovascular magnetic resonance (CMR) to evaluate how CMR indices are associated with DM or insulin resistance among participants before developing cardiac events. METHODS: We studied 1476 participants who were free of clinical cardiovascular disease and who underwent tagged CMR in the Multi-Ethnic Study of Atherosclerosis (MESA)...
July 30, 2018: Journal of Cardiovascular Magnetic Resonance
Pier-Giorgio Masci, Anna Giulia Pavon, Olivier Muller, Juan-Fernando Iglesias, Gabriella Vincenti, Pierre Monney, Brahim Harbaoui, Eric Eeckhout, Juerg Schwitter
BACKGROUND: To investigate the influence of cardiovascular magnetic resonance (CMR) timing after reperfusion on CMR-derived parameters of ischemia/reperfusion (I/R) injury in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study included 163 reperfused STEMI patients undergoing CMR during the index hospitalization. Patients were divided according to the time between revascularization and CMR (Trevasc-CMR : Tertile-1 ≤ 43; 43 < Tertile-2 ≤ 93; Tertile-3 > 93 h)...
July 23, 2018: Journal of Cardiovascular Magnetic Resonance
Mahesh Bharath Keerthivasan, Sagar Mandava, Kevin Johnson, Ryan Avery, Rajesh Janardhanan, Diego R Martin, Ali Bilgin, Maria I Altbach
BACKGROUND: Double inversion recovery (DIR) fast spin-echo (FSE) cardiovascular magnetic resonance (CMR) sequences are used clinically for black-blood T2-weighted imaging. However, these sequences suffer from slice inefficiency due to the non-selective inversion pulses. We propose a multi-band (MB) encoded DIR radial FSE (MB-DIR-RADFSE) technique to simultaneously excite two slices. This sequence has improved signal-to-noise ratio per unit time compared to a single slice excitation. It is also motion robust and enables the reconstruction of high-resolution black-blood T2-weighted images and T2 maps for the excited slices...
July 19, 2018: Journal of Cardiovascular Magnetic Resonance
Louise A E Brown, Sebastian C Onciul, David A Broadbent, Kerryanne Johnson, Graham J Fent, James R J Foley, Pankaj Garg, Pei G Chew, Kristopher Knott, Erica Dall'Armellina, Peter P Swoboda, Hui Xue, John P Greenwood, James C Moon, Peter Kellman, Sven Plein
BACKGROUND: Non-invasive assessment of myocardial ischaemia is a cornerstone of the diagnosis of coronary artery disease. Measurement of myocardial blood flow (MBF) using positron emission tomography (PET) is the current reference standard for non-invasive quantification of myocardial ischaemia. Dynamic myocardial perfusion cardiovascular magnetic resonance (CMR) offers an alternative to PET and a recently developed method with automated inline perfusion mapping has shown good correlation of MBF values between CMR and PET...
July 9, 2018: Journal of Cardiovascular Magnetic Resonance
Daniel Kiblboeck, Christian Reiter, Juergen Kammler, Pierre Schmit, Hermann Blessberger, Joerg Kellermair, Franz Fellner, Clemens Steinwender
BACKGROUND: There are limited data on patients with leadless cardiac pacemakers (LCP) undergoing magnetic resonance imaging. The aim of this prospective, single-center, observational study was to evaluate artefacts on cardiovascular magnetic resonance (CMR) images in patients with LCP. METHODS: Fifteen patients with Micra™ LCP, implanted at least 6 weeks prior to CMR scan, were enrolled and underwent either 1.5 Tesla or 3 Tesla CMR imaging. Artefacts were categorized into grade 1 (excellent image quality), grade 2 (good), grade 3 (poor) and grade 4 (non-diagnostic) for each myocardial segment...
July 5, 2018: Journal of Cardiovascular Magnetic Resonance
Hung P Do, Venkat Ramanan, Xiuling Qi, Jennifer Barry, Graham A Wright, Nilesh R Ghugre, Krishna S Nayak
BACKGROUND: Following acute myocardial infarction (AMI), microvascular integrity and function may be compromised as a result of microvascular obstruction (MVO) and vasodilator dysfunction. It has been observed that both infarcted and remote myocardial territories may exhibit impaired myocardial blood flow (MBF) patterns associated with an abnormal vasodilator response. Arterial spin labeled (ASL) CMR is a novel non-contrast technique that can quantitatively measure MBF. This study investigates the feasibility of ASL-CMR to assess MVO and vasodilator response in swine...
July 2, 2018: Journal of Cardiovascular Magnetic Resonance
Henrik Engblom, Mikael Kanski, Sascha Kopic, David Nordlund, Christos G Xanthis, Robert Jablonowski, Einar Heiberg, Anthony H Aletras, Marcus Carlsson, Håkan Arheden
BACKGROUND: Cardiovascular magnetic resonance (CMR) can be used to calculate myocardial extracellular volume fraction (ECV) by relating the longitudinal relaxation rate in blood and myocardium before and after contrast-injection to hematocrit (Hct) in blood. Hematocrit is known to vary with body posture, which could affect the calculations of ECV. The aim of this study was to test the hypothesis that there is a significant increase in calculated ECV values if the Hct is sampled after the CMR examination in supine position compared to when the patient arrives at the MR department...
June 28, 2018: Journal of Cardiovascular Magnetic Resonance
Amol S Pednekar, Hui Wang, Scott Flamm, Benjamin Y Cheong, Raja Muthupillai
BACKGROUND: Breath-hold (BH) requirement remains the limiting factor on the spatio-temporal resolution and coverage of the cine balanced steady-state free precession (bSSFP) cardiovascular magnetic resonance (CMR) imaging. In this prospective two-center clinical trial, we validated the performance of a respiratory triggered (RT) bSSFP cine sequence for evaluation of biventricular function. METHODS: Our study included 23 asymptomatic healthy subjects and 60 consecutive patients from Institute A (n = 39) and Institute B (n = 21) referred for a clinically indicated CMR study...
June 28, 2018: Journal of Cardiovascular Magnetic Resonance
Hanwei Chen, Xueping He, Guoxi Xie, Jianke Liang, Yufeng Ye, Wei Deng, Zhuonan He, Dexiang Liu, Debiao Li, Xin Liu, Zhaoyang Fan
BACKGROUND: The aim was to investigate the feasibility of a cardiovascular magnetic resonance (CMR) black-blood thrombus imaging (BBTI) technique, based on delay alternating with nutation for tailored excitation black-blood preparation and a variable flip angle turbo-spin-echo readout, for the diagnosis of acute deep vein thrombosis (DVT) at 1.5 T. METHODS: BBTI was conducted in 15 healthy subjects and 30 acute DVT patients. Contrast-enhanced CMR venography (CE-CMRV) was conducted for comparison and only performed in the patients...
June 25, 2018: Journal of Cardiovascular Magnetic Resonance
Adrienne E Campbell-Washburn, Toby Rogers, Annette M Stine, Jaffar M Khan, Rajiv Ramasawmy, William H Schenke, Delaney R McGuirt, Jonathan R Mazal, Laurie P Grant, Elena K Grant, Daniel A Herzka, Robert J Lederman
BACKGROUND: Cardiovascular magnetic resonance (CMR) fluoroscopy allows for simultaneous measurement of cardiac function, flow and chamber pressure during diagnostic heart catheterization. To date, commercial metallic guidewires were considered contraindicated during CMR fluoroscopy due to concerns over radiofrequency (RF)-induced heating. The inability to use metallic guidewires hampers catheter navigation in patients with challenging anatomy. Here we use low specific absorption rate (SAR) imaging from gradient echo spiral acquisitions and a commercial nitinol guidewire for CMR fluoroscopy right heart catheterization in patients...
June 21, 2018: Journal of Cardiovascular Magnetic Resonance
Andreas Harloff, Hanieh Mirzaee, Thomas Lodemann, Paul Hagenlocher, Thomas Wehrum, Judith Stuplich, Anja Hennemuth, Jürgen Hennig, Sebastian Grundmann, Werner Vach
BACKGROUND: Increased aortic stiffness is an independent predictor of cardiovascular disease. Optimal measurement is highly beneficial for the detection of atherosclerosis and the management of patients at risk. Thus, it was our purpose to selectively measure aortic stiffness using a novel imaging method and to provide reference values from a population-based study. METHODS: One hundred twenty six inhabitants of Freiburg, Germany, between 20 and 80 years prospectively underwent 3 Tesla cardiovascular magnetic resonance (CMR) of the thoracic aorta...
June 21, 2018: Journal of Cardiovascular Magnetic Resonance
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
Sowmya Balasubramanian, David M Harrild, Basavaraj Kerur, Edward Marcus, Pedro Del Nido, Tal Geva, Andrew J Powell
BACKGROUND: In patients with repaired tetralogy of Fallot (TOF), a better understanding of the impact of surgical pulmonary valve replacement (PVR) on ventricular mechanics may lead to improved indications and outcomes. Therefore, we used cardiovascular magnetic resonance (CMR) feature tracking analysis to quantify ventricular strain and synchrony in repaired TOF patients before and after PVR. METHODS: Thirty-six repaired TOF patients (median age 22.4 years) prospectively underwent CMR a mean of 4...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
Seung-Hoon Pi, Sung Mok Kim, Jin-Oh Choi, Eun Kyoung Kim, Sung-A Chang, Yeon Hyeon Choe, Sang-Chol Lee, Eun-Seok Jeon
BACKGROUND: It has been reported that left ventricular (LV) myocardial strain and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging have prognostic value in patients with heart failure (HF). However, previous studies included patients with various systolic functions. This study aimed to investigate the prognostic value of LV myocardial strain and LGE on CMR imaging in patients with idiopathic dilated cardiomyopathy (DCM) with reduced ejection fraction (EF < 40%)...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
Na Zhang, Fan Zhang, Zixin Deng, Qi Yang, Marcio A Diniz, Shlee S Song, Konrad H Schlick, M Marcel Maya, Nestor Gonzalez, Debiao Li, Hairong Zheng, Xin Liu, Zhaoyang Fan
BACKGROUND: One of the potentially important applications of three-dimensional (3D) intracranial vessel wall (IVW) cardiovascular magnetic resonance (CMR) is to monitor disease progression and regression via quantitative measurement of IVW morphology during medical management or drug development. However, a prerequisite for this application is to validate that IVW morphologic measurements based on the modality are reliable. In this study we performed comprehensive reliability analysis for the recently proposed whole-brain IVW CMR technique...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
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