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Journal of Cardiovascular Magnetic Resonance

Patrick Krumm, Karin A L Mueller, Karin Klingel, Ulrich Kramer, Marius S Horger, Tanja Zitzelsberger, Reinhard Kandolf, Meinrad Gawaz, Konstantin Nikolaou, Bernhard D Klumpp, Joerg C Henes
BACKGROUND: To determine morphological and functional cardiovascular magnetic resonance (CMR) patterns in histopathologically confirmed myocardial involvement in patients with systemic sclerosis (SSc). METHODS: Twenty patients (6 females; mean age 41 ± 11 years) with histopathologically proven cardiac involvement in SSc in the years 2008-2016 were retrospectively evaluated. Morphological, functional and late gadolinium enhancement (LGE) images were acquired in standard angulations at 1...
October 21, 2016: Journal of Cardiovascular Magnetic Resonance
Gang Wu, Jun Yang, Tianjing Zhang, John N Morelli, Shivraman Giri, Xiaoming Li, Wenlin Tang
BACKGROUND: The high incidence of renal insufficiency in patients with Peripheral Arterial Disease raises the concern for nephrogenic systemic fibrosis (NSF) with respect to contrast enhanced MRA. The risk of NSF is eliminated with non-contrast enhanced magnetic resonance angiography. The purpose of the current study is to compare image quality and diagnostic performance of non-contrast enhanced Quiescent Interval Single Shot (QISS) magnetic resonance angiography at 3 T versus CT angiography for evaluation of lower extremity Peripheral Arterial Disease (PAD)...
October 20, 2016: Journal of Cardiovascular Magnetic Resonance
Robert R Edelman, Marcos Botelho, Amit Pursnani, Shivraman Giri, Ioannis Koktzoglou
BACKGROUND: Dark blood imaging of the heart is conventionally performed using a breath-hold, dual-inversion Cartesian fast spin-echo pulse sequence. Our aim was to develop a faster, more flexible approach that would be less motion-sensitive and provide better image quality. For this purpose, we implemented a prototype radial balanced steady-state free precession (bSSFP) pulse sequence. METHODS: The study was approved by the institutional review board. Six healthy volunteers and 27 subjects undergoing clinically-indicated cardiovascular magnetic resonance (CMR) were imaged using dark blood Cartesian fast spin-echo and radial bSSFP...
October 19, 2016: Journal of Cardiovascular Magnetic Resonance
Kristin McLeod, Samuel Wall, Ida Skrinde Leren, Jørg Saberniak, Kristina Hermann Haugaa
BACKGROUND: Altered right ventricular structure is an important feature of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), but is challenging to quantify objectively. The aim of this study was to go beyond ventricular volumes and diameters and to explore if the shape of the right and left ventricles could be assessed and related to clinical measures. We used quantifiable computational methods to automatically identify and analyse malformations in ARVC patients from Cardiovascular Magnetic Resonance (CMR) images...
October 14, 2016: Journal of Cardiovascular Magnetic Resonance
Agnes Mayr, Daniel Kitterer, Joerg Latus, Hannah Steubing, Joerg Henes, Francesco Vecchio, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt, Simon Greulich
BACKGROUND: Severe arrhythmias or heart failure may be surrogates of myocardial involvement in patients with connective tissue disorders (CTD). However, most patients present with unspecific symptoms, normal ECG, and preserved left ventricular ejection fraction (LV-EF). Therefore, timely diagnosis by an accurate technique is crucial. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has proven value for the detection of focal processes, but due to the often diffuse character of fibrosis/inflammation in CTD patients, CMR mapping techniques might be of incremental value for the assessment of myocardial involvement...
October 13, 2016: Journal of Cardiovascular Magnetic Resonance
Rui Plácido, Bernardo Cunha Lopes, Ana G Almeida, Carlos E Rochitte
Takotsubo syndrome (TS) is a transient form of left ventricular dysfunction associated with a distinctive contraction pattern in the absence of significant coronary artery disease triggered by stressful events. Several aspects of its clinical profile have been described but it still remains difficult to quickly establish the diagnosis at admission.Cardiovascular magnetic resonance (CMR) has achieved great improvements in the last years, which in turn has made this imaging technology more attractive in the diagnosis and evaluation of TS...
October 12, 2016: Journal of Cardiovascular Magnetic Resonance
Alicia M Maceira, Juan Cosin-Sales, Sanjay K Prasad, Dudley J Pennell
BACKGROUND: Left and right atrial function show a different pattern in advanced age in order to maintain adequate ventricular filling. It has been shown that left atrial (LA) function has a prognostic value in a number of heart conditions. Cardiovascular magnetic resonance (CMR) provides high quality images of the left and right atria using high temporal resolution steady state free precession (SSFP) cine sequences. We used SSFP cines to characterize atrial function in healthy, normotensive, volunteers...
October 10, 2016: Journal of Cardiovascular Magnetic Resonance
Animesh Tandon, Lorraine James, Markus Henningsson, René M Botnar, Amanda Potersnak, Gerald F Greil, Tarique Hussain
BACKGROUND: The use of gadolinium contrast agents in cardiovascular magnetic resonance is well-established and serves to improve both vascular imaging as well as enable late gadolinium enhancement (LGE) imaging for tissue characterization. Currently, gadofosveset trisodium, an intravascular contrast agent, combined with a three-dimensional inversion recovery balanced steady state free precession (3D IR bSSFP) sequence, is commonly used in pediatric cardiac imaging and yields excellent vascular imaging, but cannot be used for late gadolinium enhancement...
October 5, 2016: Journal of Cardiovascular Magnetic Resonance
Tiago Teixeira, Tarik Hafyane, Nikola Stikov, Cansu Akdeniz, Andreas Greiser, Matthias G Friedrich
BACKGROUND: T1 mapping based on cardiovascular magnetic resonance (CMR) is a novel approach using the magnetic relaxation T1 time as a quantitative marker for myocardial tissue composition. Various T1 mapping sequences are being used, with different strengths and weaknesses. Data comparing different sequences head to head however are sparse. METHODS: We compared three T1 mapping sequences, ShMOLLI, MOLLI and SASHA in phantoms and in a mid-ventricular slice of 40 healthy individuals (mean age 59 ± 7 years, 45 % male) with low (68 %) or moderate cardiovascular risk...
October 4, 2016: Journal of Cardiovascular Magnetic Resonance
Ursula Reiter, Gert Reiter, Martin Manninger, Gabriel Adelsmayr, Julia Schipke, Alessio Alogna, Alexandra Rajces, Aurelien F Stalder, Andreas Greiser, Christian Mühlfeld, Daniel Scherr, Heiner Post, Burkert Pieske, Michael Fuchsjäger
BACKGROUND: The hypertensive deoxy-corticosterone acetate (DOCA)-salt-treated pig (hereafter, DOCA pig) was recently introduced as large animal model for early-stage heart failure with preserved ejection fraction (HFpEF). The aim of the present study was to evaluate cardiovascular magnetic resonance (CMR) of DOCA pigs and weight-matched control pigs to characterize ventricular, atrial and myocardial structure and function of this phenotype model. METHODS: Five anesthetized DOCA and seven control pigs underwent 3 T CMR at rest and during dobutamine stress...
September 30, 2016: Journal of Cardiovascular Magnetic Resonance
Litten Bertelsen, Jesper Hastrup Svendsen, Lars Køber, Ketil Haugan, Søren Højberg, Carsten Thomsen, Niels Vejlstrup
BACKGROUND: Cardiovascular magnetic resonance (CMR) is considered the gold standard of cardiac volumetric measurements. Flow in the aortic root is often measured at the sinotubular junction, even though placing the slice just above valve level may be more precise. It is unknown how much flow measurements vary at different levels in the aortic root and which level corresponds best to left ventricle volumetry. METHODS: All patients were older than 70 years presenting with at least one of the following diagnoses: diabetes, hypertension, prior stroke and/or heart failure...
September 7, 2016: Journal of Cardiovascular Magnetic Resonance
Gianni Pedrizzetti, Piet Claus, Philip J Kilner, Eike Nagel
Tissue tracking technology of routinely acquired cardiovascular magnetic resonance (CMR) cine acquisitions has increased the apparent ease and availability of non-invasive assessments of myocardial deformation in clinical research and practice. Its widespread availability thanks to the fact that this technology can in principle be applied on images that are part of every CMR or echocardiographic protocol. However, the two modalities are based on very different methods of image acquisition and reconstruction, each with their respective strengths and limitations...
August 26, 2016: Journal of Cardiovascular Magnetic Resonance
Adriana D M Villa, Eva Sammut, Niloufar Zarinabad, Gerald Carr-White, Jack Lee, Nuno Bettencourt, Reza Razavi, Eike Nagel, Amedeo Chiribiri
BACKGROUND: Microvascular ischemia is one of the hallmarks of hypertrophic cardiomyopathy (HCM) and has been associated with poor outcome. However, myocardial fibrosis, seen on cardiovascular magnetic resonance (CMR) as late gadolinium enhancement (LGE), can be responsible for rest perfusion defects in up to 30% of patients with HCM, potentially leading to an overestimation of the ischemic burden. We investigated the effect of left ventricle (LV) scar on the total LV ischemic burden using novel high-resolution perfusion analysis techniques in conjunction with LGE quantification...
January 14, 2016: Journal of Cardiovascular Magnetic Resonance
Karine Moschetti, Steffen E Petersen, Guenter Pilz, Raymond Y Kwong, Jean-Blaise Wasserfallen, Massimo Lombardi, Grigorios Korosoglou, Albert C Van Rossum, Oliver Bruder, Heiko Mahrholdt, Juerg Schwitter
BACKGROUND: Coronary artery disease (CAD) continues to be one of the top public health burden. Perfusion cardiovascular magnetic resonance (CMR) is generally accepted to detect CAD, while data on its cost effectiveness are scarce. Therefore, the goal of the study was to compare the costs of a CMR-guided strategy vs two invasive strategies in a large CMR registry. METHODS: In 3'647 patients with suspected CAD of the EuroCMR-registry (59 centers/18 countries) costs were calculated for diagnostic examinations (CMR, X-ray coronary angiography (CXA) with/without FFR), revascularizations, and complications during a 1-year follow-up...
January 11, 2016: Journal of Cardiovascular Magnetic Resonance
Paul Wexberg, Marion Avanzini, Julia Mascherbauer, Stefan Pfaffenberger, Birgit Freudenthaler, Reginald Bittner, Günther Bernert, Franz Weidinger
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked recessive disease that occurs in males leading to immobility and death in early adulthood. Female carriers of DMD are generally asymptomatic, yet frequently develop dilated cardiomyopathy. This study aims to detect early cardiac manifestation in DMD using cardiovascular magnetic resonance (CMR) and to evaluate its association with clinical symptoms. METHODS: Clinical assessment of DMD carriers included six minutes walk tests (6MWT), blood analysis, electrocardiography, echocardiography, and CMR using FLASH sequences to detect late gadolinium enhancement (LGE)...
2016: Journal of Cardiovascular Magnetic Resonance
Gabriella Captur, Peter Gatehouse, Kathryn E Keenan, Friso G Heslinga, Ruediger Bruehl, Marcel Prothmann, Martin J Graves, Richard J Eames, Camilla Torlasco, Giulia Benedetti, Jacqueline Donovan, Bernd Ittermann, Redha Boubertakh, Andrew Bathgate, Celine Royet, Wenjie Pang, Reza Nezafat, Michael Salerno, Peter Kellman, James C Moon
BACKGROUND: T1 mapping and extracellular volume (ECV) have the potential to guide patient care and serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners and pulse sequences. To help deliver T1 mapping to global clinical care, we developed a phantom-based quality assurance (QA) system for verification of measurement stability over time at individual sites, with further aims of generalization of results across sites, vendor systems, software versions and imaging sequences...
2016: Journal of Cardiovascular Magnetic Resonance
Kelly Jarvis, Marleen Vonder, Alex J Barker, Susanne Schnell, Michael Rose, James Carr, Joshua D Robinson, Michael Markl, Cynthia K Rigsby
BACKGROUND: Peak velocity measurements are used to evaluate the significance of stenosis in patients with transposition of the great arteries after the arterial switch operation (TGA after ASO). 4D flow cardiovascular magnetic resonance (CMR) provides 3-directional velocity encoding and full volumetric coverage of the great arteries and may thus improve the hemodynamic evaluation in these patients. The aim of this study was to compare peak velocities measured by 4D flow CMR with 2D phase contrast (PC) CMR and the gold standard Doppler echocardiography (echo) in patients with TGA after ASO...
2016: Journal of Cardiovascular Magnetic Resonance
Vassilios S Vassiliou, Ee Ling Heng, Peter D Gatehouse, Jacqueline Donovan, Claire E Raphael, Shivraman Giri, Sonya V Babu-Narayan, Michael A Gatzoulis, Dudley J Pennell, Sanjay K Prasad, David N Firmin
BACKGROUND: Magnetic resonance imaging (MRI) phantoms are routinely used for quality assurance in MRI centres; however their long term stability for verification of myocardial T1/ extracellular volume fraction (ECV) mapping has never been investigated. METHODS: Nickel-chloride agarose gel phantoms were formulated in a reproducible laboratory procedure to mimic blood and myocardial T1 and T2 values, native and late after Gadolinium administration as used in T1/ECV mapping...
2016: Journal of Cardiovascular Magnetic Resonance
Luigia D'Errico, Mariana M Lamacie, Laura Jimenez Juan, Djeven Deva, Rachel M Wald, Sebastian Ley, Kate Hanneman, Paaladinesh Thavendiranathan, Bernd J Wintersperger
BACKGROUND: Test-retest reproducibility is of utmost importance in follow-up of right ventricular (RV) volumes and function; optimal slice orientation though is not yet known. We compared test-retest reproducibility and intra-/inter-observer variability of right ventricular (RV) volumes and function assessed with short-axis and transverse cardiovascular magnetic resonance (CMR). METHODS: Eighteen volunteers underwent cine CMR for RV assessment obtaining ventricular coverage in short-axis and transverse slice orientation...
2016: Journal of Cardiovascular Magnetic Resonance
Giorgos Papanastasiou, Michelle C Williams, Marc R Dweck, Shirjel Alam, Annette Cooper, Saeed Mirsadraee, David E Newby, Scott I Semple
BACKGROUND: Mathematical modeling of perfusion cardiovascular magnetic resonance (CMR) data allows absolute quantification of myocardial blood flow and can potentially improve the diagnosis and prognostication of obstructive coronary artery disease (CAD), against the current clinical standard of visual assessments. This study compares the diagnostic performance of distributed parameter modeling (DP) against the standard Fermi model, for the detection of obstructive CAD, in per vessel against per patient analysis...
2016: Journal of Cardiovascular Magnetic Resonance
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