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Journal of Cardiovascular Magnetic Resonance

Jennifer A Steeden, Grzegorz T Kowalik, Oliver Tann, Marina Hughes, Kristian H Mortensen, Vivek Muthurangu
BACKGROUND: Real-time cardiovascular magnetic resonance (CMR) assessment of ventricular volumes and function enables data acquisition during free-breathing. The requirement for high spatiotemporal resolution in children necessitates the use of highly accelerated imaging techniques. METHODS: A novel real-time balanced steady state free precession (bSSFP) spiral sequence reconstructed using Compressed Sensing (CS) was prospectively validated against the breath-hold clinical standard for assessment of ventricular volumes in 60 children with congenital heart disease...
December 6, 2018: Journal of Cardiovascular Magnetic Resonance
Laura C Saunders, Chris S Johns, Neil J Stewart, Charlotte J E Oram, David A Capener, Valentina O Puntmann, Charlie A Elliot, Robin C Condliffe, David G Kiely, Martin J Graves, Jim M Wild, Andy J Swift
BACKGROUND: Native T1 may be a sensitive, contrast-free, non-invasive cardiovascular magnetic resonance (CMR) marker of myocardial tissue changes in patients with pulmonary artery hypertension. However, the diagnostic and prognostic value of native T1 mapping in this patient group has not been fully explored. The aim of this work was to determine whether elevation of native T1 in myocardial tissue in pulmonary hypertension: (a) varies according to pulmonary hypertension subtype; (b) has prognostic value and (c) is associated with ventricular function and interaction...
December 3, 2018: Journal of Cardiovascular Magnetic Resonance
Datta Singh Goolaub, Christopher W Roy, Eric Schrauben, Dafna Sussman, Davide Marini, Mike Seed, Christopher K Macgowan
PURPOSE: To image multidimensional flow in fetuses using golden-angle radial phase contrast cardiovascular magnetic resonance (PC-CMR) with motion correction and retrospective gating. METHODS: A novel PC-CMR method was developed using an ungated golden-angle radial acquisition with continuously incremented velocity encoding. Healthy subjects (n = 5, 27 ± 3 years, males) and pregnant females (n = 5, 34 ± 2 weeks gestation) were imaged at 3 T using the proposed sequence...
November 29, 2018: Journal of Cardiovascular Magnetic Resonance
Markus Henningsson, Riad Abou Zahr, Adrian Dyer, Gerald F Greil, Barbara Burkhardt, Animesh Tandon, Tarique Hussain
BACKGROUND: Volumetric black-blood cardiovascular magnetic resonance (CMR) has been hampered by long scan times and flow sensitivity. The purpose of this study was to assess the feasibility of black-blood, electrocardiogram (ECG)-triggered and respiratory-navigated 3D fast spin echo (3D FSE) for the visualization of the whole heart and great vessels. METHODS: The implemented 3D FSE technique used slice-selective excitation and non-selective refocusing pulses with variable flip angles to achieve constant echo signal for tissue with T1 (880 ms) and T2 (40 ms) similar to the vessel wall...
November 26, 2018: Journal of Cardiovascular Magnetic Resonance
R Brandon Stacey, Trinity Vera, Timothy M Morgan, Jennifer H Jordan, Matthew C Whitlock, Michael E Hall, Sujethra Vasu, Craig Hamilton, Dalane W Kitzman, W Gregory Hundley
BACKGROUND: Current guidelines for assessing the risk of experiencing a hospitalized cardiovascular (CV) event discourage stress testing of asymptomatic individuals; however, these recommendations are based on evidence gathered primarily from those aged < 60 years, and do not address the possibility of unrecognized "silent myocardial ischemia" in middle aged and older adults. METHODS: We performed dobutamine cardiovascular magnetic resonance (CMR) stress testing in 327 consecutively recruited participants aged > 55 years without CV-related symptoms nor known coronary artery disease, but otherwise at increased risk for a future CV event due to pre-existing hypertension or diabetes mellitus for at least 5 years...
November 22, 2018: Journal of Cardiovascular Magnetic Resonance
Adriana D M Villa, Laura Corsinovi, Ioannis Ntalas, Xenios Milidonis, Cian Scannell, Gabriella Di Giovine, Nicholas Child, Catarina Ferreira, Muhummad Sohaib Nazir, Julia Karady, Esmeralda Eshja, Viola De Francesco, Nuno Bettencourt, Andreas Schuster, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
BACKGROUND: Clinical evaluation of stress perfusion cardiovascular magnetic resonance (CMR) is currently based on visual assessment and has shown high diagnostic accuracy in previous clinical trials, when performed by expert readers or core laboratories. However, these results may not be generalizable to clinical practice, particularly when less experienced readers are concerned. Other factors, such as the level of training, the extent of ischemia, and image quality could affect the diagnostic accuracy...
November 19, 2018: Journal of Cardiovascular Magnetic Resonance
Maximilian Fuetterer, Julia Busch, Julia Traechtler, Patrick Wespi, Sophie M Peereboom, Mareike Sauer, Miriam Lipiski, Thea Fleischmann, Nikola Cesarovic, Christian T Stoeck, Sebastian Kozerke
BACKGROUND: The feasibility of absolute myocardial blood flow quantification and suitability of hyperpolarized [1-13 C] pyruvate as contrast agent for first-pass cardiovascular magnetic resonance (CMR) perfusion measurements are investigated with simulations and demonstrated in vivo in a swine model. METHODS: A versatile simulation framework for hyperpolarized CMR subject to physical, physiological and technical constraints was developed and applied to investigate experimental conditions for accurate perfusion CMR with hyperpolarized [1-13 C] pyruvate...
November 12, 2018: Journal of Cardiovascular Magnetic Resonance
Heerajnarain Bulluck, Mervyn H H Chan, Valeria Paradies, Robert L Yellon, He H Ho, Mark Y Chan, Calvin W L Chin, Jack W Tan, Derek J Hausenloy
INTRODUCTION: The incidence of left ventricular (LV) thrombus formation in ST-segment elevation myocardial infarction (STEMI) patients in the current era of primary percutaneous coronary intervention (PCI) is not well established. We performed a meta-analysis to assess the actual incidence and predictors of LV thrombus by cardiovascular magnetic resonance (CMR) in STEMI treated by primary PCI. METHODS: We searched MEDLINE and EMBASE databases up to February 2018...
November 8, 2018: Journal of Cardiovascular Magnetic Resonance
Shuang Leng, Ru-San Tan, Xiaodan Zhao, John C Allen, Angela S Koh, Liang Zhong
BACKGROUND: Abnormal left atrial (LA) function is a marker of cardiac dysfunction and adverse cardiovascular outcome, but is difficult to assess, and hence not, routinely quantified. We aimed to determine the feasibility and effectiveness of a fast method to measure long-axis LA strain and strain rate (SR) with standard cardiovascular magnetic resonance (CMR) compared to conventional feature tracking (FT) derived longitudinal strain. METHODS: We studied 50 normal controls, 30 patients with hypertrophic cardiomyopathy, and 100 heart failure (HF) patients, including 40 with reduced ejection fraction (HFrEF), 30 mid-range ejection fraction (HFmrEF) and 30 preserved ejection fraction (HFpEF)...
November 5, 2018: Journal of Cardiovascular Magnetic Resonance
Julien Frandon, Stéphanie Bricq, Zakarya Bentatou, Laetitia Marcadet, Pierre Antoine Barral, Mathieu Finas, Daniel Fagret, Frank Kober, Gilbert Habib, Monique Bernard, Alain Lalande, Lucile Miquerol, Alexis Jacquier
BACKGROUND: The definition of left ventricular (LV) non-compaction is controversial, and discriminating between normal and excessive LV trabeculation remains challenging. Our goal was to quantify LV trabeculation on cardiovascular magnetic resonance (CMR) images in a genetic mouse model of non-compaction using a dedicated semi-automatic software package and to compare our results to the histology used as a gold standard. METHODS: Adult mice with ventricular non-compaction were generated by conditional trabecular deletion of Nkx2-5...
October 25, 2018: Journal of Cardiovascular Magnetic Resonance
Dan Yang, Xiao Li, Jia-Yu Sun, Wei Cheng, Andreas Greiser, Tian-Jing Zhang, Hong Liu, Ke Wan, Yong Luo, Qi An, Yiu-Cho Chung, Yuchi Han, Yu-Cheng Chen
BACKGROUND: Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial fibrosis in Ebstein's anomaly have not been fully investigated. This study aimed to evaluate myocardial fibrosis using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques, and to explore the significance of myocardial fibrosis in adolescent and adult patients with Ebstein's anomaly...
September 27, 2018: Journal of Cardiovascular Magnetic Resonance
Sebastian Bohnen, Maxim Avanesov, Annika Jagodzinski, Renate B Schnabel, Tanja Zeller, Mahir Karakas, Jan Schneider, Enver Tahir, Ersin Cavus, Clemens Spink, Ulf K Radunski, Francisco Ojeda, Gerhard Adam, Stefan Blankenberg, Gunnar K Lund, Kai Muellerleile
BACKGROUND: The purpose of this work is to describe the objectives and design of cardiovascular magnetic resonance (CMR) imaging in the single center, prospective, population-based Hamburg City Health study (HCHS). The HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF). METHODS: The HCHS will finally include 45,000 inhabitants of the city of Hamburg (Germany) between 45 and 74 years who undergo an extensive cardiovascular evaluation and collection of biomaterials...
September 24, 2018: Journal of Cardiovascular Magnetic Resonance
Valentina O Puntmann, Silvia Valbuena, Rocio Hinojar, Steffen E Petersen, John P Greenwood, Christopher M Kramer, Raymond Y Kwong, Gerry P McCann, Colin Berry, Eike Nagel
Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
Shadi Akhtari, Michael L Chuang, Carol J Salton, Sophie Berg, Kraig V Kissinger, Beth Goddu, Christopher J O'Donnell, Warren J Manning
BACKGROUND: Left bundle branch block (LBBB) is associated with abnormal left ventricular (LV) contraction, and is frequently associated with co-morbid cardiovascular disease, but the effect of an isolated (i.e. in the absence of cardiovascular dissease) LBBB on biventricular volumes and ejection fraction (EF) is not well characterized. The objective of this study was to compare LV and right ventricular (RV) volumes and EF in adults with an isolated LBBB to matched healthy controls and to population-derived normative values, using cardiovascular magnetic resonance (CMR) imaging...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
Rui Guo, Zhensen Chen, Yishi Wang, Daniel A Herzka, Jianwen Luo, Haiyan Ding
BACKGROUND: This study demonstrates a three-dimensional (3D) free-breathing native myocardial T1 mapping sequence at 3 T. METHODS: The proposed sequence acquires three differently T1 -weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration...
September 17, 2018: Journal of Cardiovascular Magnetic Resonance
Wenjia Bai, Matthew Sinclair, Giacomo Tarroni, Ozan Oktay, Martin Rajchl, Ghislain Vaillant, Aaron M Lee, Nay Aung, Elena Lukaschuk, Mihir M Sanghvi, Filip Zemrak, Kenneth Fung, Jose Miguel Paiva, Valentina Carapella, Young Jin Kim, Hideaki Suzuki, Bernhard Kainz, Paul M Matthews, Steffen E Petersen, Stefan K Piechnik, Stefan Neubauer, Ben Glocker, Daniel Rueckert
BACKGROUND: Cardiovascular resonance (CMR) imaging is a standard imaging modality for assessing cardiovascular diseases (CVDs), the leading cause of death globally. CMR enables accurate quantification of the cardiac chamber volume, ejection fraction and myocardial mass, providing information for diagnosis and monitoring of CVDs. However, for years, clinicians have been relying on manual approaches for CMR image analysis, which is time consuming and prone to subjective errors. It is a major clinical challenge to automatically derive quantitative and clinically relevant information from CMR images...
September 14, 2018: Journal of Cardiovascular Magnetic Resonance
Gregory J Wehner, Linyuan Jing, Christopher M Haggerty, Jonathan D Suever, Jing Chen, Sean M Hamlet, Jared A Feindt, W Dimitri Mojsejenko, Mark A Fogel, Brandon K Fornwalt
BACKGROUND: Cardiovascular magnetic resonance (CMR) feature tracking is increasingly used to quantify cardiac mechanics from cine CMR imaging, although validation against reference standard techniques has been limited. Furthermore, studies have suggested that commonly-derived metrics, such as peak global strain (reported in 63% of feature tracking studies), can be quantified using contours from just two frames - end-diastole (ED) and end-systole (ES) - without requiring tracking software...
September 13, 2018: Journal of Cardiovascular Magnetic Resonance
Rajiv Ramasawmy, Toby Rogers, Miguel A Alcantar, Delaney R McGuirt, Jaffar M Khan, Peter Kellman, Hui Xue, Anthony Z Faranesh, Adrienne E Campbell-Washburn, Robert J Lederman, Daniel A Herzka
BACKGROUND: The hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR). METHODS: Swine were administered 0.7 mg/kg ferumoxytol and blood pool T1 was measured repeatedly for an hour to characterize contrast agent extraction and subsequent effect on Vblood estimates...
September 10, 2018: Journal of Cardiovascular Magnetic Resonance
Yongjun Han, Maobin Guan, Zhu Zhu, Dongye Li, Huijun Chen, Chun Yuan, Cheng Li, Wei Wang, Xihai Zhao
BACKGROUND: Lower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segments of femoral arteries. We sought to investigate the longitudinal distribution of subclinical femoral artery atherosclerosis in asymptomatic elderly adults using cardiovascular magnetic resonance (CMR) vessel wall imaging...
September 3, 2018: Journal of Cardiovascular Magnetic Resonance
Pankaj Garg, Saul Crandon, Peter P Swoboda, Graham J Fent, James R J Foley, Pei G Chew, Louise A E Brown, Sethumadhavan Vijayan, Mariëlla E C J Hassell, Robin Nijveldt, Malenka Bissell, Mohammed S M Elbaz, Abdallah Al-Mohammad, Jos J M Westenberg, John P Greenwood, Rob J van der Geest, Sven Plein, Erica Dall'Armellina
BACKGROUND: Myocardial infarction (MI) leads to complex changes in left ventricular (LV) haemodynamics that are linked to clinical outcomes. We hypothesize that LV blood flow kinetic energy (KE) is altered in MI and is associated with LV function and infarct characteristics. This study aimed to investigate the intra-cavity LV blood flow KE in controls and MI patients, using cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow assessment. METHODS: Forty-eight patients with MI (acute-22; chronic-26) and 20 age/gender-matched healthy controls underwent CMR which included cines and whole-heart 4D flow...
August 30, 2018: Journal of Cardiovascular Magnetic Resonance
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