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Journal of Cardiovascular Magnetic Resonance

Dan Yang, Xiao Li, Jia-Yu Sun, Wei Cheng, Andreas Greiser, Tian-Jing Zhang, Hong Liu, Ke Wan, Yong Luo, Qi An, Yiu-Cho Chung, Yuchi Han, Yu-Cheng Chen
BACKGROUND: Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial fibrosis in Ebstein's anomaly have not been fully investigated. This study aimed to evaluate myocardial fibrosis using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques, and to explore the significance of myocardial fibrosis in adolescent and adult patients with Ebstein's anomaly...
September 27, 2018: Journal of Cardiovascular Magnetic Resonance
Sebastian Bohnen, Maxim Avanesov, Annika Jagodzinski, Renate B Schnabel, Tanja Zeller, Mahir Karakas, Jan Schneider, Enver Tahir, Ersin Cavus, Clemens Spink, Ulf K Radunski, Francisco Ojeda, Gerhard Adam, Stefan Blankenberg, Gunnar K Lund, Kai Muellerleile
BACKGROUND: The purpose of this work is to describe the objectives and design of cardiovascular magnetic resonance (CMR) imaging in the single center, prospective, population-based Hamburg City Health study (HCHS). The HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF). METHODS: The HCHS will finally include 45,000 inhabitants of the city of Hamburg (Germany) between 45 and 74 years who undergo an extensive cardiovascular evaluation and collection of biomaterials...
September 24, 2018: Journal of Cardiovascular Magnetic Resonance
Valentina O Puntmann, Silvia Valbuena, Rocio Hinojar, Steffen E Petersen, John P Greenwood, Christopher M Kramer, Raymond Y Kwong, Gerry P McCann, Colin Berry, Eike Nagel
Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more chronic and indolent course. These include an increased deployment of safe screening methods, life-long surveillance, and monitoring of both disease activity and tailored-treatment, by way of increasingly personalized medical care. Cardiovascular magnetic resonance (CMR) is a non-invasive, ionising radiation-free method, which can support a significant number of clinically relevant measurements and offers new opportunities to advance the state of art of diagnosis, prognosis and treatment...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
Shadi Akhtari, Michael L Chuang, Carol J Salton, Sophie Berg, Kraig V Kissinger, Beth Goddu, Christopher J O'Donnell, Warren J Manning
BACKGROUND: Left bundle branch block (LBBB) is associated with abnormal left ventricular (LV) contraction, and is frequently associated with co-morbid cardiovascular disease, but the effect of an isolated (i.e. in the absence of cardiovascular dissease) LBBB on biventricular volumes and ejection fraction (EF) is not well characterized. The objective of this study was to compare LV and right ventricular (RV) volumes and EF in adults with an isolated LBBB to matched healthy controls and to population-derived normative values, using cardiovascular magnetic resonance (CMR) imaging...
September 20, 2018: Journal of Cardiovascular Magnetic Resonance
Rui Guo, Zhensen Chen, Yishi Wang, Daniel A Herzka, Jianwen Luo, Haiyan Ding
BACKGROUND: This study demonstrates a three-dimensional (3D) free-breathing native myocardial T1 mapping sequence at 3 T. METHODS: The proposed sequence acquires three differently T1 -weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration...
September 17, 2018: Journal of Cardiovascular Magnetic Resonance
Wenjia Bai, Matthew Sinclair, Giacomo Tarroni, Ozan Oktay, Martin Rajchl, Ghislain Vaillant, Aaron M Lee, Nay Aung, Elena Lukaschuk, Mihir M Sanghvi, Filip Zemrak, Kenneth Fung, Jose Miguel Paiva, Valentina Carapella, Young Jin Kim, Hideaki Suzuki, Bernhard Kainz, Paul M Matthews, Steffen E Petersen, Stefan K Piechnik, Stefan Neubauer, Ben Glocker, Daniel Rueckert
BACKGROUND: Cardiovascular resonance (CMR) imaging is a standard imaging modality for assessing cardiovascular diseases (CVDs), the leading cause of death globally. CMR enables accurate quantification of the cardiac chamber volume, ejection fraction and myocardial mass, providing information for diagnosis and monitoring of CVDs. However, for years, clinicians have been relying on manual approaches for CMR image analysis, which is time consuming and prone to subjective errors. It is a major clinical challenge to automatically derive quantitative and clinically relevant information from CMR images...
September 14, 2018: Journal of Cardiovascular Magnetic Resonance
Gregory J Wehner, Linyuan Jing, Christopher M Haggerty, Jonathan D Suever, Jing Chen, Sean M Hamlet, Jared A Feindt, W Dimitri Mojsejenko, Mark A Fogel, Brandon K Fornwalt
BACKGROUND: Cardiovascular magnetic resonance (CMR) feature tracking is increasingly used to quantify cardiac mechanics from cine CMR imaging, although validation against reference standard techniques has been limited. Furthermore, studies have suggested that commonly-derived metrics, such as peak global strain (reported in 63% of feature tracking studies), can be quantified using contours from just two frames - end-diastole (ED) and end-systole (ES) - without requiring tracking software...
September 13, 2018: Journal of Cardiovascular Magnetic Resonance
Rajiv Ramasawmy, Toby Rogers, Miguel A Alcantar, Delaney R McGuirt, Jaffar M Khan, Peter Kellman, Hui Xue, Anthony Z Faranesh, Adrienne E Campbell-Washburn, Robert J Lederman, Daniel A Herzka
BACKGROUND: The hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR). METHODS: Swine were administered 0.7 mg/kg ferumoxytol and blood pool T1 was measured repeatedly for an hour to characterize contrast agent extraction and subsequent effect on Vblood estimates...
September 10, 2018: Journal of Cardiovascular Magnetic Resonance
Yongjun Han, Maobin Guan, Zhu Zhu, Dongye Li, Huijun Chen, Chun Yuan, Cheng Li, Wei Wang, Xihai Zhao
BACKGROUND: Lower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segments of femoral arteries. We sought to investigate the longitudinal distribution of subclinical femoral artery atherosclerosis in asymptomatic elderly adults using cardiovascular magnetic resonance (CMR) vessel wall imaging...
September 3, 2018: Journal of Cardiovascular Magnetic Resonance
Pankaj Garg, Saul Crandon, Peter P Swoboda, Graham J Fent, James R J Foley, Pei G Chew, Louise A E Brown, Sethumadhavan Vijayan, Mariëlla E C J Hassell, Robin Nijveldt, Malenka Bissell, Mohammed S M Elbaz, Abdallah Al-Mohammad, Jos J M Westenberg, John P Greenwood, Rob J van der Geest, Sven Plein, Erica Dall'Armellina
BACKGROUND: Myocardial infarction (MI) leads to complex changes in left ventricular (LV) haemodynamics that are linked to clinical outcomes. We hypothesize that LV blood flow kinetic energy (KE) is altered in MI and is associated with LV function and infarct characteristics. This study aimed to investigate the intra-cavity LV blood flow KE in controls and MI patients, using cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow assessment. METHODS: Forty-eight patients with MI (acute-22; chronic-26) and 20 age/gender-matched healthy controls underwent CMR which included cines and whole-heart 4D flow...
August 30, 2018: Journal of Cardiovascular Magnetic Resonance
Emmanuelle Vermes, Clémence Pantaléon, Adrien Auvet, Nicolas Cazeneuve, Marie Christine Machet, Anne Delhommais, Thierry Bourguignon, Michel Aupart, Laurent Brunereau
BACKGROUND: The diagnosis of acute rejection in cardiac transplant recipients requires invasive technique with endomyocardial biopsy (EMB) which has risks and limitations. Cardiovascular magnetic resonance imaging (CMR) with T2 and T1 mapping is a promising technique for characterizing myocardial tissue. The purpose of the study was to evaluate T2, T1 and extracellular volume fraction (ECV) quantification as novel tissue markers to diagnose acute rejection. METHODS: CMR was prospectively performed in 20 heart transplant patients providing 31 comparisons EMB-CMR...
August 27, 2018: Journal of Cardiovascular Magnetic Resonance
Fourat Ridouani, Thibaud Damy, Vania Tacher, Haytham Derbel, François Legou, Islem Sifaoui, Etienne Audureau, Diane Bodez, Alain Rahmouni, Jean-François Deux
BACKGROUND: To assess the diagnostic and prognosis value of myocardial native T2 measurement in the distinction between Light-chain (AL) and Transthyretin (ATTR) cardiac amyloidosis (CA). METHODS: Forty-four patients with CA (24 AL; 20 ATTR) and 40 healthy subjects underwent 1.5 T cardiovascular magnetic resonance (CMR). They all underwent T1 and T2 mapping (modified Look-Locker inversion recovery), cine and late gadolinium enhancement (LGE) imaging. The Query Amyloid Late Enhancement (QALE) score, myocardial native T2, T1 and extra cellular volume fraction (ECV) were calculated for all patients...
August 16, 2018: Journal of Cardiovascular Magnetic Resonance
R J Kim, O P Simonetti, M Westwood, C M Kramer, A Narang, M G Friedrich, A J Powell, J C Carr, J Schulz-Menger, E Nagel, W S Chan, J Bremerich, K G Ordovas, R C Rollings, A R Patel, V A Ferrari
These "Guidelines for training in Cardiovascular Magnetic Resonance" were developed by the Certification Committee of the Society for Cardiovascular Magnetic Resonance (SCMR) and approved by the SCMR Board of Trustees.
August 16, 2018: Journal of Cardiovascular Magnetic Resonance
Yongning Shang, Xiaochun Zhang, Xiaoyue Zhou, Jian Wang
BACKGROUND: The extracellular volume (ECV), derived from cardiovascular magnetic resonance (CMR) T1 mapping, is a biomarker of the extracellular space in the myocardium. The hematocrit (HCT), measured from venipuncture, is required for ECV measurement. We test the clinic values of synthetic ECV, which is derived from the longitudinal relaxation of blood-based (T1blood ) synthetic hematocrit in 3 T CMR. METHODS: A total of 226 subjects with CMR T1 mapping and HCT measurement taken on the same day as the CMR were retrospectively enrolled and randomly split into derivation (n = 121) and validation (n = 105) groups, comprising healthy subjects (n = 45), type 2 diabetes mellitus (T2DM) patients (n = 60), hypertrophic cardiomyopathy (HCM) patients (n = 93), and 28 other patients...
August 9, 2018: Journal of Cardiovascular Magnetic Resonance
Clotilde Roy, Alisson Slimani, Christophe de Meester, Mihaela Amzulescu, Agnes Pasquet, David Vancraeynest, Christophe Beauloye, Jean-Louis Vanoverschelde, Bernhard L Gerber, Anne-Catherine Pouleur
BACKGROUND: Increased myocardial fibrosis may play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology. The study aim was to evaluate the presence, associations, and prognostic significance of diffuse fibrosis in HFpEF patients compared to age- and sex-matched controls. METHODS: We prospectively included 118 consecutive HFpEF patients. Diffuse myocardial fibrosis was estimated by extracellular volume (ECV) quantified by cardiovascular magnetic resonance with the modified Look-Locker inversion recovery sequence...
August 8, 2018: Journal of Cardiovascular Magnetic Resonance
Ali Serhal, Ioannis Koktzoglou, Pascale Aouad, James C Carr, Shivraman Giri, Omar Morcos, Robert R Edelman
BACKGROUND: Comparing cardiovascular magnetic resonance (CMR) angiography with computed tomography angiography (CTA), a major deficiency has been its inability to reliably image peripheral vascular calcifications that may impact the choice of interventional strategy and influence patient prognosis. Recently, MRI using a proton density-weighted, in-phase stack of stars (PDIP-SOS) technique has proved capable of detecting these calcifications. The goal of the present study was two-fold: (1) to determine whether magnetic field strength impacts the apparent size and conspicuity of ilio-femoral arterial calcifications; and (2) to determine whether the technique can be accurately applied to image aorto-iliac arterial calcifications...
August 6, 2018: Journal of Cardiovascular Magnetic Resonance
Anouk L M Eikendal, Michiel L Bots, Aisha Gohar, Esther Lutgens, Imo E Hoefer, Hester M den Ruijter, Tim Leiner
BACKGROUND: Although endothelial cell adhesion molecules (CAMs) are postulated to play a key role in early atherosclerosis, studies on endothelial CAMs are mainly pertained to middle-aged populations and populations with an unfavourable cardiovascular risk burden. Therefore, this study evaluated whether circulating endothelial CAMs are related to cardiovascular magnetic resonance imaging (CMR) derived indicators of arterial wall alterations in a random sample of young adults from the general population...
August 2, 2018: Journal of Cardiovascular Magnetic Resonance
Masafumi Nii, Masaki Ishida, Kaoru Dohi, Hiroaki Tanaka, Eiji Kondo, Masaaki Ito, Hajime Sakuma, Tomoaki Ikeda
BACKGROUND: Peripartum cardiomyopathy is a life-threatening condition that occurs during the peripartum period in previously healthy women. Cardiovascular magnetic resonance (CMR) T1 mapping permits sensitive detection of tissue edema and fibrosis, and it may be useful in identifying altered myocardial tissue characteristics in peripartum cardiomyopathy. However, left ventricular (LV) volumes and mass increase considerably even in normal pregnancy, and it is not known whether altered tissue characteristics can be found in normal pregnancy...
August 2, 2018: Journal of Cardiovascular Magnetic Resonance
Kihei Yoneyama, Bharath A Venkatesh, Colin O Wu, Nathan Mewton, Ola Gjesdal, Satoru Kishi, Robyn L McClelland, David A Bluemke, João A C Lima
BACKGROUND: Although diabetes mellitus (DM) and insulin resistance associate with adverse cardiac events, the associations of left ventricular (LV) remodeling and function with compromised glucose metabolism have not been fully evaluated in a general population. We used cardiovascular magnetic resonance (CMR) to evaluate how CMR indices are associated with DM or insulin resistance among participants before developing cardiac events. METHODS: We studied 1476 participants who were free of clinical cardiovascular disease and who underwent tagged CMR in the Multi-Ethnic Study of Atherosclerosis (MESA)...
July 30, 2018: Journal of Cardiovascular Magnetic Resonance
Pier-Giorgio Masci, Anna Giulia Pavon, Olivier Muller, Juan-Fernando Iglesias, Gabriella Vincenti, Pierre Monney, Brahim Harbaoui, Eric Eeckhout, Juerg Schwitter
BACKGROUND: To investigate the influence of cardiovascular magnetic resonance (CMR) timing after reperfusion on CMR-derived parameters of ischemia/reperfusion (I/R) injury in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study included 163 reperfused STEMI patients undergoing CMR during the index hospitalization. Patients were divided according to the time between revascularization and CMR (Trevasc-CMR : Tertile-1 ≤ 43; 43 < Tertile-2 ≤ 93; Tertile-3 > 93 h)...
July 23, 2018: Journal of Cardiovascular Magnetic Resonance
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