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Journal of Cardiovascular Magnetic Resonance

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https://www.readbyqxmd.com/read/29228952/association-between-left-ventricular-mechanics-and-diffuse-myocardial-fibrosis-in-patients-with-repaired-tetralogy-of-fallot-a-cross-sectional-study
#1
Christopher M Haggerty, Jonathan D Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J Wehner, Linyuan Jing, Richard J Charnigo, Brandon K Fornwalt, Mark A Fogel
BACKGROUND: Patients with repaired tetralogy of Fallot (TOF) have progressive, adverse biventricular remodeling, leading to abnormal contractile mechanics. Defining the mechanisms underlying this dysfunction, such as diffuse myocardial fibrosis, may provide insights into poor long-term outcomes. We hypothesized that left ventricular (LV) diffuse fibrosis is related to impaired LV mechanics. METHODS: Patients with TOF were evaluated with cardiac magnetic resonance in which modified Look-Locker (MOLLI) T1-mapping and spiral cine Displacement encoding (DENSE) sequences were acquired at three LV short-axis positions...
December 11, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29212513/cardiac-amyloidosis-is-prevalent-in-older-patients-with-aortic-stenosis-and-carries-worse-prognosis
#2
João L Cavalcante, Shasank Rijal, Islam Abdelkarim, Andrew D Althouse, Michael S Sharbaugh, Yaron Fridman, Prem Soman, Daniel E Forman, John T Schindler, Thomas G Gleason, Joon S Lee, Erik B Schelbert
BACKGROUND: Non-invasive cardiac imaging allows detection of cardiac amyloidosis (CA) in patients with aortic stenosis (AS). Our objective was to estimate the prevalence of clinically suspected CA in patients with moderate and severe AS referred for cardiovascular magnetic resonance (CMR) in age and gender categories, and assess associations between AS-CA and all-cause mortality. METHODS: We retrospectively identified consecutive AS patients defined by echocardiography referred for further CMR assessment of valvular, myocardial, and aortic disease...
December 7, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29212500/correction-to-adenosine-stress-cmr-t1-mapping-detects-early-microvascular-dysfunction-in-patients-with-type-2-diabetes-mellitus-without-obstructive-coronary-artery-disease
#3
Eylem Levelt, Stefan K Piechnik, Alexander Liu, Rohan S Wijesurendra, Masliza Mahmod, Rina Ariga, Jane M Francis, Andreas Greiser, Kieran Clarke, Stefan Neubauer, Vanessa M Ferreira, Theodoros D Karamitsos
In the original publication of this article [1] Fig. 1 was incorrect due to the use of a colour bar with wrong range in error.
December 7, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29202847/effects-of-adenosine-and-regadenoson-on-hemodynamics-measured-using-cardiovascular-magnetic-resonance-imaging
#4
Dustin M Thomas, Matthew R Minor, James K Aden, Christopher J Lisanti, Kevin E Steel
BACKGROUND: Adenosine or regadenoson vasodilator stress cardiovascular magnetic resonance (CMR) is an effective non-invasive strategy for evaluating symptomatic coronary artery disease. Vasodilator injection typically precedes ventricular functional sequences to efficiently reduce overall scanning times, though the effects of vasodilators on CMR-derived ventricular volumes and function are unknown. METHODS: We prospectively enrolled 25 healthy subjects to undergo consecutive adenosine and regadenoson administration...
December 4, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29202776/-image-navigated-3-dimensional-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-imaging-feasibility-and-initial-clinical-results
#5
Konstantinos Bratis, Markus Henningsson, Chrysanthos Grigoratos, Matteo Dell'Omodarme, Konstantinos Chasapides, Rene Botnar, Eike Nagel
BACKGROUND: Image-navigated 3-dimensional late gadolinium enhancement (iNAV-3D LGE) is an advanced imaging technique that allows for direct respiratory motion correction of the heart. Its feasibility in a routine clinical setting has not been validated. METHODS: Twenty-three consecutive patients referred for cardiovascular magnetic resonance (CMR) examination including late gadolinium enhancement (LGE) imaging were prospectively enrolled. Image-navigated free-breathing 3-dimensional (3D) T1-weighted gradient-echo LGE and two-dimensional (2D LGE) images were acquired in random order on a 1...
December 4, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29191206/optimized-cest-cardiovascular-magnetic-resonance-for-assessment-of-metabolic-activity-in-the-heart
#6
Zhengwei Zhou, Christopher Nguyen, Yuhua Chen, Jaime L Shaw, Zixin Deng, Yibin Xie, James Dawkins, Eduardo Marbán, Debiao Li
BACKGROUND: Previous studies have linked cardiac dysfunction to loss of metabolites in the creatine kinase system. Chemical exchange saturation transfer (CEST) is a promising metabolic cardiovascular magnetic resonance (CMR) imaging technique and has been applied in the heart for creatine mapping. However, current limitations include: (a) long scan time, (b) residual cardiac and respiratory motion, and (c) B0 field variations induced by respiratory motion. An improved CEST CMR technique was developed to address these problems...
November 30, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29178905/diagnostic-performance-of-semi-quantitative-and-quantitative-stress-cmr-perfusion-analysis-a-meta-analysis
#7
REVIEW
R van Dijk, M van Assen, R Vliegenthart, G H de Bock, P van der Harst, M Oudkerk
BACKGROUND: Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high spatial resolution and absence of radiation. Semi-quantitative and quantitative analysis of CMR perfusion are based on signal-intensity curves produced during the first-pass of gadolinium contrast. Multiple semi-quantitative and quantitative parameters have been introduced. Diagnostic performance of these parameters varies extensively among studies and standardized protocols are lacking...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29178894/changes-in-overall-ventricular-myocardial-architecture-in-the-setting-of-a-porcine-animal-model-of-right-ventricular-dilation
#8
Peter Agger, Christine Ilkjær, Christoffer Laustsen, Morten Smerup, Jesper R Frandsen, Steffen Ringgaard, Michael Pedersen, John B Partridge, Robert H Anderson, Vibeke Hjortdal
BACKGROUND: Chronic pulmonary regurgitation often leads to myocardial dysfunction and heart failure. It is not fully known why secondary hypertrophy cannot fully protect against the increase in wall stress brought about by the increased end-diastolic volume in ventricular dilation. It has been assumed that mural architecture is not deranged in this situation, but we hypothesised that there might be a change in the pattern of orientation of the aggregations of cardiomyocytes, which would contribute to contractile impairment...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29178893/3d-whole-heart-phase-sensitive-inversion-recovery-cmr-for-simultaneous-black-blood-late-gadolinium-enhancement-and-bright-blood-coronary-cmr-angiography
#9
Giulia Ginami, Radhouene Neji, Imran Rashid, Amedeo Chiribiri, Tevfik F Ismail, René M Botnar, Claudia Prieto
BACKGROUND: Phase sensitive inversion recovery (PSIR) applied to late gadolinium enhancement (LGE) imaging is widely used in clinical practice. However, conventional 2D PSIR LGE sequences provide sub-optimal contrast between scar tissue and blood pool, rendering the detection of subendocardial infarcts and scar segmentation challenging. Furthermore, the acquisition of a low flip angle reference image doubles the acquisition time without providing any additional diagnostic information...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29162123/prospective-comparison-of-novel-dark-blood-late-gadolinium-enhancement-with-conventional-bright-blood-imaging-for-the-detection-of-scar
#10
Rohin Francis, Peter Kellman, Tushar Kotecha, Andrea Baggiano, Karl Norrington, Ana Martinez-Naharro, Sabrina Nordin, Daniel S Knight, Roby D Rakhit, Tim Lockie, Philip N Hawkins, James C Moon, Derek J Hausenloy, Hui Xue, Michael S Hansen, Marianna Fontana
BACKGROUND: Conventional bright blood late gadolinium enhancement (bright blood LGE) imaging is a routine cardiovascular magnetic resonance (CMR) technique offering excellent contrast between areas of LGE and normal myocardium. However, contrast between LGE and blood is frequently poor. Dark blood LGE (DB LGE) employs an inversion recovery T2 preparation to suppress the blood pool, thereby increasing the contrast between the endocardium and blood. The objective of this study is to compare the diagnostic utility of a novel DB phase sensitive inversion recovery (PSIR) LGE CMR sequence to standard bright blood PSIR LGE...
November 21, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29157268/the-impact-of-signal-to-noise-ratio-diffusion-weighted-directions-and-image-resolution-in-cardiac-diffusion-tensor-imaging-insights-from-the-ex-vivo-rat-heart
#11
Darryl McClymont, Irvin Teh, Jürgen E Schneider
BACKGROUND: Cardiac diffusion tensor imaging (DTI) is limited by scan time and signal-to-noise (SNR) restrictions. This invariably leads to a trade-off between the number of averages, diffusion-weighted directions (ND), and image resolution. Systematic evaluation of these parameters is therefore important for adoption of cardiac DTI in clinical routine where time is a key constraint. METHODS: High quality reference DTI data were acquired in five ex-vivo rat hearts...
November 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29157260/high-resolution-and-accelerated-multi-parametric-mapping-with-automated-characterization-of-vessel-disease-using-intravascular-mri
#12
Guan Wang, Yi Zhang, Shashank Sathyanarayana Hegde, Paul A Bottomley
BACKGROUND: Atherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular magnetic resonance imaging (IVMRI) measures of relaxation times (T1, T2) and proton density (PD) in a clinical 3 Tesla scanner could characterize vessel disease, and evaluates a practical strategy for accelerated quantification. METHODS: IVMRI was performed in fresh human artery segments and swine vessels in vivo, using fast multi-parametric sequences, 1-2 mm diameter loopless antennae and 200-300 μm resolution...
November 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29121971/cmr-based-blood-oximetry-via-multi-parametric-estimation-using-multiple-t2-measurements
#13
Juliet Varghese, Lee C Potter, Richard LaFountain, Xueliang Pan, Subha V Raman, Rizwan Ahmad, Orlando P Simonetti
BACKGROUND: Measurement of blood oxygen saturation (O2 saturation) is of great importance for evaluation of patients with many cardiovascular diseases, but currently there are no established non-invasive methods to measure blood O2 saturation in the heart. While T2-based CMR oximetry methods have been previously described, these approaches rely on technique-specific calibration factors that may not generalize across patient populations and are impractical to obtain in individual patients...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29121956/regional-differences-in-prognostic-value-of-cardiac-valve-plane-displacement-in-systemic-light-chain-amyloidosis
#14
Marco M Ochs, Thomas Fritz, Nisha Arenja, Johannes Riffel, Florian Andre, Derliz Mereles, Fabian Aus dem Siepen, Ute Hegenbart, Stefan Schönland, Hugo A Katus, Matthias G W Friedrich, Sebastian J Buss
BACKGROUND: To compare the prognostic value of cardiac valve plane displacement (CVPD) on various locations in cardiac light chain (AL) amyloidosis. METHODS: Consecutive patients with biopsy-proven cardiac involvement in AL amyloidosis who had undergone cardiovascular magnetic resonance (CMR) between 2005 and 2014 in our institution, were retrospectively identified and data analyzed. The primary combined endpoint was all-cause mortality or heart transplantation...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29117866/ambulatory-systolic-blood-pressure-and-obesity-are-independently-associated-with-left-ventricular-hypertrophic-remodeling-in-children
#15
Linyuan Jing, Christopher D Nevius, Cassi M Friday, Jonathan D Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, H Lester Kirchner, William J Cochran, Gregory J Wehner, Aftab S Chishti, Christopher M Haggerty, Brandon K Fornwalt
BACKGROUND: Children with obesity have hypertrophic cardiac remodeling. Hypertension is common in pediatric obesity, and may independently contribute to hypertrophy. We hypothesized that both the degree of obesity and ambulatory blood pressure (ABP) would independently associate with measures of hypertrophic cardiac remodeling in children. METHODS: Children, aged 8-17 years, prospectively underwent cardiovascular magnetic resonance (CMR) and ABP monitoring. Left ventricular (LV) mass indexed to height(2...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29110717/bayesian-intravoxel-incoherent-motion-parameter-mapping-in-the-human-heart
#16
Georg R Spinner, Constantin von Deuster, Kerem C Tezcan, Christian T Stoeck, Sebastian Kozerke
BACKGROUND: Intravoxel incoherent motion (IVIM) imaging of diffusion and perfusion in the heart suffers from high parameter estimation error. The purpose of this work is to improve cardiac IVIM parameter mapping using Bayesian inference. METHODS: A second-order motion-compensated diffusion weighted spin-echo sequence with navigator-based slice tracking was implemented to collect cardiac IVIM data in early systole in eight healthy subjects on a clinical 1.5 T CMR system...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29110679/high-throughput-gadobutrol-enhanced-cmr-a-time-and-dose-optimization-study
#17
Tommaso D'Angelo, Chrysanthos Grigoratos, Silvio Mazziotti, Konstantinos Bratis, Faraz Pathan, Alfredo Blandino, Elen Elen, Valentina O Puntmann, Eike Nagel
BACKGROUND: Reducing time and contrast agent doses are important goals to provide cost-efficient cardiovascular magnetic resonance (CMR) imaging. Limited information is available regarding the feasibility of evaluating left ventricular (LV) function after gadobutrol injection as well as defining the lowest dose for high quality scar imaging. We sought to evaluate both aspects separately and systematically to provide an optimized protocol for contrast-enhanced CMR (CE-CMR) using gadobutrol...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29110669/a-comparison-of-cardiovascular-magnetic-resonance-and-single-photon-emission-computed-tomography-spect-perfusion-imaging-in-left-main-stem-or-equivalent-coronary-artery-disease-a-ce-marc-substudy
#18
James R J Foley, Ananth Kidambi, John D Biglands, Neil Maredia, Catherine J Dickinson, Sven Plein, John P Greenwood
BACKGROUND: Assessment of left main stem (LMS) stenosis has prognostic and therapeutic implications. Data on assessment of LMS disease by cardiovascular magnetic resonance (CMR) and single photon emission computed tomography (SPECT) are limited. CE-MARC is the largest prospective comparison of CMR and SPECT against quantitative invasive coronary angiography (QCA) for detection of coronary artery disease (CAD), and provided the framework for this evaluation. The aims of this study were to compare diagnostic accuracy of visual and quantitative perfusion CMR to SPECT in patients with LMS stable CAD...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29084542/non-contrast-mr-angiography-at-1-5-tesla-for-aortic-monitoring-in-marfan-patients-after-aortic-root-surgery
#19
Simon Veldhoen, Cyrus Behzadi, Alexander Lenz, Frank Oliver Henes, Meike Rybczynski, Yskert von Kodolitsch, Thorsten Alexander Bley, Gerhard Adam, Peter Bannas
BACKGROUND: Contrast-enhanced cardiovascular magnetic resonance angiography (CE-CMRA) is the established imaging modality for patients with Marfan syndrome requiring life-long annual aortic imaging before and after aortic root replacement. Contrast-free CMRA techniques avoiding side-effects of contrast media are highly desirable for serial imaging but have not been evaluated in the postoperative setup of Marfan patients. The purpose of this study was to assess the feasibility of non-contrast balanced steady-state free precession (bSSFP) magnetic resonance imaging for aortic monitoring of postoperative patients with Marfan syndrome...
October 30, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29070069/adenosine-stress-cmr-t1-mapping-detects-early-microvascular-dysfunction-in-patients-with-type-2-diabetes-mellitus-without-obstructive-coronary-artery-disease
#20
Eylem Levelt, Stefan K Piechnik, Alexander Liu, Rohan S Wijesurendra, Masliza Mahmod, Rina Ariga, Jane M Francis, Andreas Greiser, Kieran Clarke, Stefan Neubauer, Vanessa M Ferreira, Theodoros D Karamitsos
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with coronary microvascular dysfunction in the absence of obstructive coronary artery disease (CAD). Cardiovascular magnetic resonance (CMR) T1-mapping at rest and during adenosine stress can assess coronary vascular reactivity. We hypothesised that the non-contrast T1 response to vasodilator stress will be altered in patients with T2DM without CAD compared to controls due to coronary microvascular dysfunction. METHODS: Thirty-one patients with T2DM and sixteen matched healthy controls underwent CMR (3 T) for cine, rest and adenosine stress non-contrast T1-mapping (ShMOLLI), first-pass perfusion and late gadolinium enhancement (LGE) imaging...
October 25, 2017: Journal of Cardiovascular Magnetic Resonance
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