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Journal of Alzheimer's Disease: JAD

Yiren Qin, Yu Zhang, Inge Tomic, Wenlin Hao, Michael D Menger, Chunfeng Liu, Klaus Fassbender, Yang Liu
Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by extracellular amyloid-β (Aβ) deposits and intracellular neurofibrillary tangles (NFT) in many brain regions. NFT are primarily composed of hyperphosphorylated tau protein (p-Tau). Aβ and p-Tau are two major pathogenic molecules with tau acting downstream to Aβ to induce neuronal degeneration. In this study, we investigated whether Ginkgo biloba extract EGb 761 reduces cerebral p-Tau level and prevents AD pathogenesis...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Alessandro Padovani, Alberto Benussi, Valentina Cantoni, Valentina Dell'Era, Maria Sofia Cotelli, Salvatore Caratozzolo, Rosanna Turrone, Luca Rozzini, Antonella Alberici, Daniele Altomare, Alessandro Depari, Alessandra Flammini, Giovanni B Frisoni, Barbara Borroni
BACKGROUND: Considering the increasing evidence that disease-modifying treatments for Alzheimer's disease (AD) must be administered early in the disease course, the development of diagnostic tools capable of accurately identifying AD at early disease stages has become a crucial target. In this view, transcranial magnetic stimulation (TMS) has become an effective tool to discriminate between different forms of neurodegenerative dementia. OBJECTIVE: To determine whether a TMS multi-paradigm approach can be used to correctly identify mild cognitive impairment (MCI) due to AD (AD MCI)...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Noemi Malandrino, Esmeralda Capristo, Tracey H Taveira, Geltrude Mingrone, Wen-Chih Wu
BACKGROUND/OBJECTIVE: Normal weight obesity (NWO) is associated with increased risk of metabolic syndrome, cardiovascular- and all-cause mortality. However, no data have been reported on the relationship between adiposity and cognitive performance in NWO. We therefore studied the association between cognitive function and body fat percentage (BF%) in NWO, using a representative sample of the United States population. METHODS: A cross-sectional study was performed using the nationwide 1988 to 1994 data set from the Third National Health and Nutrition Examination Survey...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Ning Liu, Zhanyang Yu, Yu Xun, Pan Shu, Yiwei Yue, Shishan Yuan, Yinghua Jiang, Zixuan Huang, Xiaoping Yang, Xing Feng, Shuanglin Xiang, Xiaoying Wang
Neuroglobin (Ngb) has been reported to be increased in early and moderately advanced Alzheimer's disease (AD) stages but declined in the severe stage. However, its regulatory mechanisms and pathophysiological roles in the disease remain to be defined. In this study, we found that Ngb expression was significantly upregulated by low dose Aβ25-35, the neurotoxic fragment of Aβ1 - 40 and Aβ1 - 42, but was not further increased by a higher dose of Aβ25-35. Mutation analysis and supershift assay demonstrated that transcription factor Nuclear Factor κB (NFκB), κB2 and κB3 sites located in mouse Ngb promoter region were involved in dynamic regulation of Ngb expression in response to different doses of Aβ25-35 stimulation...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Leila Sellami, Martina Bocchetta, Mario Masellis, David M Cash, Katrina M Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Jason D Warren, Jonathan D Rohrer, Robert Laforcem
BACKGROUND: The overlap between frontotemporal dementia (FTD) and primary psychiatric disorders has been brought to light by reports of prominent neuropsychiatric symptoms (NPS) in FTD-related genetic mutations, particularly among C9orf72 and GRN carriers. It has been recently demonstrated that early neuroanatomical changes in genetic FTD may be different across the major disease-causing mutations. OBJECTIVE: We aimed to identify whether NPS could be driven by distinct structural correlates...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Nadja Smailagic, Louise Lafortune, Sarah Kelly, Chris Hyde, Carol Brayne
BACKGROUND: A previous Cochrane systematic review concluded there is insufficient evidence to support the routine use of 18F-FDG PET in clinical practice in people with mild cognitive impairment (MCI). OBJECTIVES: To update the evidence and reassess the accuracy of 18F-FDG-PET for detecting people with MCI at baseline who would clinically convert to Alzheimer's disease (AD) dementia at follow-up. METHODS: A systematic review including comprehensive search of electronic databases from January 2013 to July 2017, to update original searches (1999 to 2013)...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Yordenca Lamartinière, Marie-Christine Boucau, Lucie Dehouck, Markus Krohn, Jens Pahnke, Pietra Candela, Fabien Gosselet, Laurence Fenart
The role of ABCA7 in brain homeostasis and Alzheimer's disease (AD) is currently under intense scrutiny, since it has been reported that polymorphisms in the Abca7 gene and a loss of function of the protein are closely linked to excessive accumulation of amyloid peptides and disturbed cholesterol homeostasis. The blood-brain barrier (BBB), which isolates the brain from the blood compartment, is involved in both of these processes. We therefore hypothesized that ABCA7 downregulation might affect cholesterol and amyloid exchanges at the BBB...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Matthias Brendel, Julia Sauerbeck, Sonja Greven, Sebastian Kotz, Franziska Scheiwein, Janusch Blautzik, Andreas Delker, Oliver Pogarell, Kazunari Ishii, Peter Bartenstein, Axel Rominger
Late-life depression, even when of subsyndromal severity, has shown strong associations with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we aimed to investigate the effect of SSRI medication on amyloidosis and grey matter volume in subsyndromal depressed subjects with MCI and AD during an interval of two years. 256 cognitively affected subjects (225 MCI/ 31 AD) undergoing [18F]-AV45-PET and MRI at baseline and 2-year follow-up were selected from the ADNI database...
July 13, 2018: Journal of Alzheimer's Disease: JAD
Adrià Casamitjana, Paula Petrone, Alan Tucholka, Carles Falcon, Stavros Skouras, José Luis Molinuevo, Verónica Vilaplana, Juan Domingo Gispert
The identification of healthy individuals harboring amyloid pathology constitutes one important challenge for secondary prevention clinical trials in Alzheimer's disease (AD). Consequently, noninvasive and cost-efficient techniques to detect preclinical AD constitute an unmet need of critical importance. In this manuscript, we apply machine learning to structural MRI (T1 and DTI) of 96 cognitively normal subjects to identify amyloid-positive ones. Models were trained on public ADNI data and validated on an independent local cohort...
July 12, 2018: Journal of Alzheimer's Disease: JAD
Hua Ni, Min Xu, Gui-Lai Zhan, Yu Fan, Hejiang Zhou, Hong-Yan Jiang, Wei-Hong Lu, Liwen Tan, Deng-Feng Zhang, Yong-Gang Yao, Chen Zhang
Depression is one of the most frequent psychiatric symptoms observed in people during the development of Alzheimer's disease (AD). We hypothesized that genetic factors conferring risk of depression might affect AD development. In this study, we screened 31 genes, which were located in 19 risk loci for major depressive disorder (MDD) identified by two recent large genome-wide association studies (GWAS), in AD patients at the genomic and transcriptomic levels. Association analysis of common variants was performed by using summary statistics of the International Genomics of Alzheimer's Project (IGAP), and association analysis of rare variants was conducted by sequencing the entire coding region of the 31 MDD risk genes in 107 Han Chinese patients with early-onset and/or familial AD...
July 12, 2018: Journal of Alzheimer's Disease: JAD
Dimitri Renard, Lavinia Tatu, Laurent Collombier, Anne Wacongne, Xavier Ayrignac, Mahmoud Charif, Yassine Boukriche, Laura Chiper, Genevieve Fourcade, Souhayla Azakri, Nicolas Gaillard, Erick Mercier, Sylvain Lehmann, Eric Thouvenot
BACKGROUND: Cerebral amyloid angiopathy (CAA) can be associated with primary vasculitis of small/medium-sized leptomeningeal and cortical arteries, called CAA-related inflammation (CAA-ri). OBJECTIVE: To compare hemorrhagic and diffusion-weighted imaging (DWI) MRI features in CAA and CAA-ri. METHODS: We prospectively scored in a consecutive CAA and CAA-ri cohort: presence/number of chronic intracerebral hemorrhage (ICH), cerebral microbleeds (CMB), and cortical superficial siderosis (CSS) on initial T2*-weighted imaging, and DWI lesions on both initial and follow-up imaging...
July 12, 2018: Journal of Alzheimer's Disease: JAD
Simone Baiardi, Sabina Capellari, Anna Bartoletti Stella, Piero Parchi
The introduction of prion RT-QuIC, the first fully specific assay for the in vivo detection of the abnormal prion protein, has significantly increased the potential for an early and accurate clinical diagnosis of Creutzfeldt-Jakob disease (CJD). However, in the clinical setting, the early identification of patients with possible CJD is often challenging. Indeed, CJD patients may present with isolated symptoms that remain the only clinical manifestation for some time, or with neurological syndromes atypical for CJD...
July 12, 2018: Journal of Alzheimer's Disease: JAD
Heather E Whitson, Guy G Potter, Jody A Feld, Brenda L Plassman, Kelly Reynolds, Richard Sloane, Kathleen A Welsh-Bohmer
BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task condition compared to the single-task condition. OBJECTIVE: To examine how gait-cognition dual-task performance differs between cognitively normal older adults with and without an APOE ɛ4 allele. METHODS: Twenty-nine individuals ages 60 to 72 with normal cognition completed a dual-task protocol in which walking and cognitive tasks (executive function, memory) were performed separately and concurrently...
July 12, 2018: Journal of Alzheimer's Disease: JAD
Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Raffaele Cacciaglia, Marc Suárez-Calvet, Carles Falcon, Carolina Minguillon, Nina Gramunt, Aleix Sala-Vila, Juan Domingo Gispert, José Luis Molinuevo
BACKGROUND: Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. OBJECTIVE: To study the clinical, cognitive, and structural neuroimaging characteristics of psychometrically normal subjects without self-awareness of cognitive decline (unaware decliners, UD) and to compare them with SCD participants and controls. METHODS: 2,640 participants from the ALFA cohort, 1,899 controls, 173 UD (decline reported by the informant only), and 568 SCD underwent clinical and cognitive explorations...
July 10, 2018: Journal of Alzheimer's Disease: JAD
Sue Jones, Anne Killett, Eneida Mioshi
BACKGROUND: Dementia Cafés are community support groups which provide post-diagnostic support for families affected by dementia. However, little is known about the characteristics of caregivers who attend Cafés. OBJECTIVES: To describe the demographic and psychosocial characteristics of caregivers who attend Dementia Cafés, and to identify which of those factors may influence the likelihood of family caregivers attending Dementia Cafés. METHODS: A cross-sectional study on caregivers (n = 80; July 2016- July 2017)...
July 6, 2018: Journal of Alzheimer's Disease: JAD
Christian Sande Musaeus, Knut Engedal, Peter Hgh, Vesna Jelic, Morten Mrup, Mala Naik, Anne-Rita Oeksengaard, Jon Snaedal, Lars-Olof Wahlund, Gunhild Waldemar, Birgitte Bo Andersen
BACKGROUND: Quantitative EEG (qEEG) power could potentially be used as a diagnostic tool for Alzheimer's disease (AD) and may further our understanding of the pathophysiology. However, the early qEEG power changes of AD are not well understood. OBJECTIVE: To investigate the early changes in qEEG power and the possible correlation with memory function and cerebrospinal fluid biomarkers. In addition, whether qEEG power could discriminate between AD, mild cognitive impairment (MCI), and older healthy controls (HC) at the individual level...
July 6, 2018: Journal of Alzheimer's Disease: JAD
Brianne A Kent, Stephen M Strittmatter, Haakon Nygaard
BACKGROUND: Sleep disturbances have long been associated with Alzheimer's disease (AD), and there is a growing interest in how these disturbances might impact AD pathophysiology. Despite this growing interest, surprisingly little is known about how sleep architecture and the broader neuronal network are affected in widely used transgenic mouse models of AD. OBJECTIVE: We analyzed sleep and electroencephalography (EEG) power in three transgenic mouse models of AD, using identical and commercially available hardware and analytical software...
July 6, 2018: Journal of Alzheimer's Disease: JAD
Bruno Bonnechère, Mélissa Van Vooren, Jean-Christophe Bier, Sandra De Breucker, Olivier Van Hove, Serge Van Sint Jan, Véronique Feipel, Bart Jansen
BACKGROUND: In the past few years numerous mobile games have been developed to train the brain. There is a lack of information about the relation between the scores obtained in these games and the cognitive abilities of the patients. OBJECTIVE: The aim of this study was to determine whether or not mobile games can be used to assess cognitive abilities of elderly. METHODS: Twenty healthy young adults, 29 old patients with cognitive impairments (Mini-Mental State Exam (MMSE) [20- 24]) and 27-aged controls participated in this study...
July 6, 2018: Journal of Alzheimer's Disease: JAD
Camilla Thygesen, Athanasios Metaxas, Martin R Larsen, Bente Finsen
BACKGROUND: Alzheimer's disease (AD), the most common cause of dementia, is characterized by the intra- and extracellular aggregation and accumulation of proteins. The major molecular hallmark is the aggregation of amyloid-β (Aβ) and hyperphosphorylated tau proteins into plaques and tangles, respectively. Evidence points to the pre-fibrillary states of protein aggregates harboring the greatest neurotoxicity. OBJECTIVE: This study was designed to identify and quantify pre-fibrillary protein species enriched by their insolubility in the detergent sarkosyl in the APPSWE/PS1ΔE9 (APP/PS1) transgenic mouse model of AD...
July 6, 2018: Journal of Alzheimer's Disease: JAD
Jihui Lyu, Jingnan Zhang, Haiyan Mu, Wenjie Li, Champ Mei, Xiong Qian, Tian Gao, Lijuan Xie, Weiye Jin, Wan Yang, Mengnan Cui, Maolong Gao, Mo Li
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia, affecting millions of older people worldwide. However, pharmacological therapies have not achieved desirable clinical efficacy in the past decades. Non-pharmacological therapies have been receiving increased attention to treat dementia in recent years. OBJECTIVE: This study explores the effects of music therapy on cognitive function and mental wellbeing of patients with AD. METHODS: A total number of 298 AD patients with mild, moderate, or severe dementia participated in the study...
July 6, 2018: Journal of Alzheimer's Disease: JAD
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