Read by QxMD icon Read

Journal of Alzheimer's Disease: JAD

Alfonso J Alfini, Lauren R Weiss, Kristy A Nielson, Matthew D Verber, J Carson Smith
BACKGROUND: Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain's neural infrastructure. OBJECTIVE: To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (versus CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences...
January 9, 2019: Journal of Alzheimer's Disease: JAD
Sonia Ben Jemaa, Yousri Marzouki, Mohamed Ben Fredj, Didier Le Gall, Tarek Bellaj
BACKGROUND: Depression is a major disorder that can be triggering, co-occurring, or exacerbating dementia symptoms. Its assessment is paramount to achieve diagnostic, prognostic, and therapeutic decisions. The Cornell Scale for Depression in Dementia (CSDD) is purposely designed to address clinically this issue. OBJECTIVE: To examine the reliability and validity of an Arabic version of the CSDD (A-CSDD) in the Tunisian population. METHODS: Fifty-seven participants took part in this study: 20 as a control group (NC), 18 as dementia patients with depression (DD), and 19 as depressed patients without dementia (DND); all patients met the DSM IV criteria for depression and/or dementia...
January 9, 2019: Journal of Alzheimer's Disease: JAD
Branko N Huisa, Ronald G Thomas, Shelia Jin, Tilman Oltersdorf, Curtis Taylor, Howard H Feldman
BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly prescribed medications for Alzheimer's disease (AD). Their concurrent use in AD randomized clinical trials (RCTs) is generally allowed but their effect in outcome measures is unsettled. OBJECTIVE: To evaluate whether use of AChEIs and/or memantine across AD RCTs are associated with different rates of cognitive/functional decline. METHODS: We pooled data from 5 RCTs of mild to moderate AD conducted by the Alzheimer's Disease Cooperative Study (ADCS) between 2002-2013...
January 8, 2019: Journal of Alzheimer's Disease: JAD
Payam Emami Khoonsari, Ganna Shevchenko, Stephanie Herman, Julia Remnestål, Vilmantas Giedraitis, RoseMarie Brundin, Malin Degerman Gunnarsson, Lena Kilander, Henrik Zetterberg, Peter Nilsson, Lars Lannfelt, Martin Ingelsson, Kim Kultima
BACKGROUND: Alzheimer's disease (AD) is diagnosed based on a clinical evaluation as well as analyses of classical biomarkers: Aβ42, total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF). Although the sensitivities and specificities of the classical biomarkers are fairly good for detection of AD, there is still a need to develop novel biochemical markers for early detection of AD. OBJECTIVE: We explored if integration of novel proteins with classical biomarkers in CSF can better discriminate AD from non-AD subjects...
January 3, 2019: Journal of Alzheimer's Disease: JAD
Daniel J Levendowski, Charlene Gamaldo, Erik K St Louis, Luigi Ferini-Strambi, Joanne M Hamilton, David Salat, Philip Westbrook, Chris Berka
BACKGROUND: The characterization of sleep in those with neurodegenerative disease (NDD) is essential in understanding the potential neurobiological mechanisms that underlie the connection between sleep disruption and NDD manifestations and progression. OBJECTIVE: Explore the inter-relationships between NDD and age, sex, diagnosis of obstructive sleep apnea, snoring, and duration of sleep time with the head in the supine and non-supine positions. METHODS: A case-control design was used to evaluate differences in sleep position obtained from multi-night, in-home Sleep Profiler recordings in 45 patients with diagnosed NDD (24 with mild cognitive impairment, 15 with Alzheimer's disease, and 6 with Lewy Body, Parkinson's, or other dementias) and 120 age-sex matched controls with normal cognition (NC)...
December 31, 2018: Journal of Alzheimer's Disease: JAD
Chiara Stella Turchetta, Roberta Perri, Lucia Fadda, Giulia Caruso, Maria Stefania De Simone, Carlo Caltagirone, Giovanni Augusto Carlesimo
No abstract text is available yet for this article.
December 28, 2018: Journal of Alzheimer's Disease: JAD
Liang Hui, L Mahmoud Soliman, H Nicholas Geiger, M Nicole Miller, Zahra Afghah, L Koffi Lakpa, Xuesong Chen, D Jonathan Geiger
Cholesterol dyshomeostasis has been linked to the pathogenesis of sporadic Alzheimer's disease (AD). In furthering the understanding of mechanisms by which increased levels of circulating cholesterol augments the risk of developing sporadic AD, others and we have reported that low-density lipoprotein (LDL) enters brain parenchyma by disrupting the blood-brain barrier and that endolysosome de-acidification plays a role in LDL-induced amyloidogenesis in neurons. Here, we tested the hypothesis that endolysosome de-acidification was central to amyloid-β (Aβ) generation and that acidifying endolysosomes protects against LDL-induced increases in Aβ levels in neurons...
December 28, 2018: Journal of Alzheimer's Disease: JAD
Zulzikry Hafiz Abu Bakar, Hanafi Ahmad Damanhuri, Suzana Makpol, Wan Mohd Aizat Wan Kamaruddin, Nur Fathiah Abdul Sani, Ahmad Imran Zaydi Amir Hamzah, Khairun Nain Nor Aripin, Mohd Dzulkhairi Mohd Rani, Nor Azila Noh, Rosdinom Razali, Musalmah Mazlan, Hamzaini Abdul Hamid, Mazlyfarina Mohamad, Wan Zurinah Wan Ngah
BACKGROUND: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. OBJECTIVE: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. METHODS: A total of 160 individuals were recruited and grouped accordingly...
December 26, 2018: Journal of Alzheimer's Disease: JAD
Alar Kaskikallio, Mira Karrasch, Juha O Rinne, Terhi Tuokkola, Riitta Parkkola, Petra Grönholm-Nyman
We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, η2  = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology...
December 24, 2018: Journal of Alzheimer's Disease: JAD
Patrick Oeckl, Steffen Halbgebauer, Sarah Anderl Straub, Petra Steinacker, André M Huss, Hermann Neugebauer, Christine A F von Arnim, Janine Diehl Schmid, Timo Grimmer, Johannes Kornhuber, Piotr Lewczuk, Adrian Danek, Albert C Ludolph, Markus Otto
Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p <  0.001) and DLB/PDD (p <  0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p <  0.001). Serum GFAP correlated with Mini-Mental State Examination score (r= -0...
December 24, 2018: Journal of Alzheimer's Disease: JAD
Simon Ducharme, Leora Pearl-Dowler, Flora Gossink, Jillian McCarthy, Jimmy Lai, Bradford C Dickerson, Howard Chertkow, Lucile Rapin, Everard Vijverberg, Welmoed Krudop, Annemieke Dols, Yolande Pijnenburg
BACKGROUND: Differentiating early behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD) is complex and biomarkers have limited accuracy, leading to inaccurate diagnoses. OBJECTIVES: Develop a simple bedside clinical tool to differentiate bvFTD from PPD. METHODS: A checklist of clinical features differentiating bvFTD from PPD was developed based on literature and clinical experience. The checklist was filled prospectively for 29 consecutive patients (Montreal Neurological Hospital) with late-onset (≥ age 40) behavioral changes suggestive of bvFTD...
December 21, 2018: Journal of Alzheimer's Disease: JAD
Iris Escobar, Jing Xu, Charles W Jackson, Miguel A Perez-Pinzon
Cerebral ischemia remains a leading cause of mortality worldwide. Although the incidence of death has decreased over the years, surviving patients may suffer from long-term cognitive impairments and have an increased risk for dementia. Unfortunately, research aimed toward developing therapies that can improve cognitive outcomes following cerebral ischemia has proved difficult given the fact that little is known about the underlying processes involved. Nevertheless, mechanisms that disrupt neural network activity may provide valuable insight, since disturbances in both local and global networks in the brain have been associated with deficits in cognition...
December 20, 2018: Journal of Alzheimer's Disease: JAD
Antonella Marino Gammazza, Vincenzo Restivo, Roberta Baschi, Celeste Caruso Bavisotto, Angelo B Cefalù, Giulia Accardi, Everly Conway de Macario, Alberto J L Macario, Francesco Cappello, Roberto Monastero
Molecular chaperones play essential roles in many processes such as cell differentiation, tissue homeostasis, and organ remodeling. Recent data indicate that chaperones can act as cytoprotectants for brain cells during the progression of neurodegenerative diseases, including Alzheimer's disease (AD). However, very few data on the levels of chaperones in dementia, including its prodromal phases, have been reported. In this study, we used biological samples and epidemiological data collected during the Zabùt Aging Project (a prospective, community-based, cohort study of normal/pathological aging conducted in Sicily, Italy, with a follow-up of ten years) to determine if there is an association between plasma levels of the chaperones Hsp60, Hsp70, and Hsp90 with amnestic mild cognitive impairment (aMCI) and AD...
December 20, 2018: Journal of Alzheimer's Disease: JAD
Lanxia Meng, Mingyang He, Min Xiong, Xingyu Zhang, Shuke Nie, Jing Xiong, Dan Hu, Zhaohui Zhang, Ling Mao, Zhentao Zhang
The etiology and pathogenesis of Alzheimer's disease (AD) are not fully understood. Thus, there are no drugs available that can provide a cure for it. We and others found that DNA polymerase-β (DNA pol-β) is required for neuronal death in several neurodegenerative models. In the present study, we tested the effect of a DNA pol-β inhibitor 2',3'- Dideoxycytidine (DDC) in AD models both in vitro and in vivo. DDC protected primary neurons from amyloid-β (Aβ)-induced toxicity by inhibiting aberrant DNA replication mediated by DNA pol- β...
December 20, 2018: Journal of Alzheimer's Disease: JAD
Javiera Gavilan, Daniela Mennickent, Oscar Ramirez-Molina, Sergio Triviño, Claudia Perez, Tiare Silva Grecchi, Pamela Godoy, Jose Becerra, Luis Aguayo, Gustavo Moraga, Victoria San Martin, Gonzalo Yevenes, Patricio Castro, Leonardo Guzman
Alzheimer's disease (AD) is a neurodegenerative pathology, which is characterized by progressive and irreversible cognitive impairment. Most of the neuronal perturbations described in AD can be associated with soluble amyloid- β oligomers (SO-Aβ). There is a large amount of evidence demonstrating the neuroprotective effect of Nicotine neurotransmission in AD, mainly through nicotinic acetylcholine receptor (nAChR) activation and antiapoptotic PI3K/Akt/Bcl-2 pathway signaling. Using HPLC and GC/MS, we isolated and characterized two alkaloids obtained from C...
December 19, 2018: Journal of Alzheimer's Disease: JAD
Charisse N Winston, Brent Aulston, Edward M Rockenstein, Anthony Adame, Olga Prikhodko, Kishan N Dave, Priyanka Mishra, Robert A Rissman, Shauna H Yuan
Progressive accumulation of aggregation-prone proteins, amyloid-β (Aβ) and hyperphosphorylated tau (p-tau), are the defining hallmarks of Alzheimer's disease (AD). The mechanisms by which Aβ and p-tau are transmitted throughout the diseased brain are not yet completely understood. Interest in exosome research has grown dramatically over the past few years, specifically due to their potential role as biomarkers for staging of neurodegenerative diseases, including AD. Despite their diagnostic utility, the pathogenic potential of exosomes has yet to be fully elucidated...
December 19, 2018: Journal of Alzheimer's Disease: JAD
Ina Zwingmann, Bernhard Michalowsky, Alexander Esser, Anika Kaczynski, Jessica Monsees, Armin Keller, Johannes Hertel, Diana Wucherer, Jochen René Thyrian, Tilly Eichler, Ingo Kilimann, Stefan Teipel, Adina Dreier Wolfgramm, Wolfgang Hoffmann
BACKGROUND: Caregivers providing informal care for people with dementia (PwD) often report unmet needs, burden, and health impairments. Optimal support for family dementia caregivers will likely benefit from better understanding and assessment of the prevalence and types of caregivers' unmet needs and associated socio-demographic and clinical characteristics. OBJECTIVE: The present study investigates 1) the number and types of caregivers' unmet needs, 2) socio-demographic and clinical characteristics of both PwD and caregivers, and 3) caregivers' burden and health-related outcomes that are related to caregivers' unmet needs...
December 19, 2018: Journal of Alzheimer's Disease: JAD
Carolina Delgado, Rodrigo C Vergara, Melissa Martínez, Gada Musa, Fernando Henríquez, Andrea Slachevsky
BACKGROUND: Neuropsychiatric symptoms and cognitive impairment are independent contributors of functional impairment in activities of daily living (ADL) in Alzheimer's disease (AD) patients. ADL could be divided according to its complexity in three subdomains: basic (BADL), instrumental (IADL), and advanced (a-ADL). OBJECTIVE: Studying the cognitive and neuropsychiatric determinants of BADL, IADL, and a-ADL in normal cognitive elders and AD patients. METHODS: 144 subjects were graduated using the clinical dementia rating (CDR) in CDR = 0, n = 52 (control group) and 92 AD patients CDR = 0...
December 18, 2018: Journal of Alzheimer's Disease: JAD
Rudy J Castellani, George Perry
There is considerable interest in the pathobiology of tau protein, given its potential role in neurodegenerative diseases and aging. Tau is an important microtubule associated protein, required for the assembly of tubulin into microtubules and maintaining structural integrity of axons. Tau has other diverse cellular functions involving signal transduction, cellular proliferation, developmental neurobiology, neuroplasticity, and synaptic activity. Alternative splicing results in tau isoforms with differing microtubule binding affinity, differing representation in pathological inclusions in certain disease states, and differing roles in developmental biology and homeostasis...
December 18, 2018: Journal of Alzheimer's Disease: JAD
Simin Mahinrad, Ian Ferguson, Peter W Macfarlane, Elaine N Clark, David J Stott, Ian Ford, Simon P Mooijaart, Stella Trompet, Diana van Heemst, J Wouter Jukema, Behnam Sabayan
BACKGROUND: An abnormally wide spatial QRS-T angle on an ECG is a marker of heterogeneity in electrical activity of cardiac ventricles and is linked with cardiovascular events. Growing evidence suggests that cardiac dysfunction might signal future cognitive decline. OBJECTIVE: In this study, we investigated whether spatial QRS-T angle associates with future cognitive decline in older subjects at high cardiovascular risk. METHODS: We included 4,172 men and women (mean age 75...
December 18, 2018: Journal of Alzheimer's Disease: JAD
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"