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Iranian Biomedical Journal

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https://www.readbyqxmd.com/read/28088132/expression-and-secretion-of-cyan-fluorescent-protein-cfp-in-b-subtilis-using-the-chitinase-promoter-from-bacillus-pumilus-sg2
#1
Abbas Shali, Garshasb Rigi, Majid Pornour, Gholamreza Ahmadian
Background: Improved cyan fluorescent protein (ICFP) is a monochromic, green fluorescent protein (GFP) derivative produced by Aequorea macrodactyla in a process similar to GFP. This protein has strong absorption spectra at wavelengths 426-446 nm. ICFP can be used in cell, organelle or intracellular protein labeling, investigating the protein-protein interactions as well as assessing the promoter activities. Methods: In our previous study, the promoters of two chitinases (ChiS and ChiL) from Bacillus pumilus SG2 were assessed in B...
15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28042145/hippocampal-expression-of-connexin36-and-connexin43-during-epileptogenesis-in-pilocarpine-model-of-epilepsy
#2
Sahel Motaghi, Mohammad Sayyah, Vahab Babapour, Reza Mahdian
BACKGROUND: Gap junctions (GJs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (Cx). The role of Cxs in epileptogenesis has not received sufficient attention. Hippocampus with critical function in epileptogenesis has a wide network of GJs. We examined the protein expression levels of hippocampal Cx36 (the prominent Cx present between GABAergic interneurons) and Cx43 (the main Cx expressed by astrocytes) during epileptogenesis in the pilocarpine model of epilepsy...
January 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27874107/the-effect-of-oral-consumption-of-probiotics-in-prevention-of-heart-injury-in-a-rat-myocardial-infarction-model-a-histopathological-hemodynamic-and-biochemical-evaluation
#3
Jafar Sadeghzadeh, Abedin Vakili, Hamid Reza Sameni, Mahdi Shadnoush, Ahmad-Reza Bandegi, Mahdi Zahedi Khorasani
BACKGROUND: Despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. METHODS: Four viable probiotics bacterial strains, including Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus and Lactobacillus acidophilus, at the concentrations of 2×106 colony-forming units/ml were orally administered to the rats daily for 14 days before the induction of infarct-like myocardial injury using isoproterenol...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27874106/is-leukocyte-telomere-length-related-with-lung-cancer-risk-a-meta-analysis
#4
Behrooz Karimi, Masud Yunesian, Ramin Nabizadeh, Parvin Mehdipour, Afsaneh Aghaie
BACKGROUND: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. METHODS: A systematic search was carried out using PubMed, EMBASE, and ISI before 2015...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27869251/an-increased-genotoxic-risk-in-lymphocytes-from-phototherapy-treated-hyperbilirubinemic-neonates
#5
Seyed Alireza Mesbah-Namin, Maryam Shahidi, Maryam Nakhshab
BACKGROUND: Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. METHODS: Newborns were divided into three groups, including phototherapy-treated (PT, n=30) jaundiced newborns with total serum bilirubin (TSB) levels >15 mg/dl, non-treated jaundiced newborns (C+, n=27), as positive, as well as healthy negative (C-, n=30) controls with TSB levels ranging from 10 and 15 mg/dl and less than 5 mg/dl, respectively...
November 21, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27805073/comparing-anti-hepatitis-b-antibody-level-in-iranian-obese-or-overweight-with-non-obese-cases
#6
Ali Kabir, Abdolreza Pazouki, Motahareh Jafari, Somayye Mokhber, Mohammad Vaziri, Seyed Moayed Alavian
BACKGROUND: There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. METHODS: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran. RESULTS: Obese cases had lower percentage of liver diseases (66...
November 2, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27794585/a-novel-defensin-like-peptide-associated-with-two-other-new-cationic-antimicrobial-peptides-in-transcriptome-of-the-iranian-scorpion-venom
#7
Masoumeh Baradaran, Amir Jalali, Maryam Naderi Soorki, Hamid Galehdari
INTRODUCTION: Scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (AMPs) have been found in the venom gland of scorpions. Therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. Here, we describe three new cationic AMPs, including meuVAP-6, meuAP-18-1, and meuPep34 from the venom gland of the Iranian scorpion, Mesobuthus eupeus. METHODS: The cDNA sequences encoding all the three peptides were obtained from the cDNA library of scorpion venom gland and were deposited in the GenBank database...
October 30, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28088131/number-crunching-towards-molecular-barcoding
#8
Soroush Sardari
No abstract text is available yet for this article.
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28088130/vaccine-candidates-against-nontypeable-haemophilus-influenzae-a-review
#9
REVIEW
Ava Behrouzi, Farzam Vaziri, Fatemeh Rahimi-Jamnani, Parviz Afrough, Mohammad Rahbar, Fereshteh Satarian, Seyed Davar Siadat
Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory tract of adults...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28000798/identification-and-evaluation-of-novel-drug-targets-against-the-human-fungal-pathogen-aspergillus-fumigatus-with-elaboration-on-the-possible-role-of-rna-binding-protein
#10
Saeid Malekzadeh, Soroush Sardari, Parisa Azerang, Dorsa Khorasanizadeh, Solmaz Agha Amiri, Mohammad Azizi, Nazanin Mohajerani, Vahid Khalaj
BACKGROUND: Aspergillus fumigatus is an airborne opportunistic fungal pathogen that can cause fatal infections in immunocompromised patients. Although the current anti-fungal therapies are relatively efficient, some issues such as drug toxicity, drug interactions, and the emergence of drug-resistant fungi have promoted the intense research toward finding the novel drug targets. METHODS: In search of new antifungal drug targets, we have used a bioinformatics approach to identify novel drug targets...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27941964/study-break-bacterial-cancer
#11
Marjan Mohammadi
No abstract text is available yet for this article.
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27805072/evaluation-of-an-albumin-binding-domain-protein-fused-to-recombinant-human-il-2-and-its-effects-on-the-bioactivity-and-serum-half-life-of-the-cytokine
#12
Elham Adabi, Fateme Saebi, Amin Moradi Hasan-Abad, Ladan Teimoori-Toolabi, Gholam Ali Kardar
BACKGROUND: Background: Cancer immunotherapy is a promising strategy for cancer treatment. In this strategy, the immune system is triggered to destroy cancer cells. IL-2 is an important factor in passive cancer immunotherapy that helps modulating some important immune functions. One of the IL-2 limitations is low serum half-life; therefore, repetitive high doses of the injections are required to maintain effective concentrations. High-dose IL-2 therapy results in severe side effects; thus, improvement of its serum half-life would provide therapeutic benefits...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27703278/ghrelin-exerts-analgesic-effects-through-modulation-of-il-10-and-tgf-%C3%AE-levels-in-a-rat-model-of-inflammatory-pain
#13
Faranak Azizzadeh, Javad Mahmoodi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Gisou Mohaddes
BACKGROUND: Ghrelin is a peptide with attenuating effect on inflammatory pain. Both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. IL-10 and TGF-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. In this study, the effects of i.p. injection of ghrelin on the early and the late phases of pain, as well as serum levels of IL-10 and TGF-β, as anti-inflammatory cytokines, were investigated in formalin-induced pain in male rats...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27695030/phosphorylation-of-staphylococcus-aureus-protein-tyrosine-kinase-affects-the-function-of-glucokinase-and-biofilm-formation
#14
Dudipeta Vasu, Pasupuleti Santhosh Kumar, Uppu Venkateswara Prasad, Vimjam Swarupa, Sthanikam Yeswanth, Lokanathan Srikanth, Manne Mudhu Sunitha, Abhijith Choudhary, Potukuchi Venkata Gurunadha Krishna Sarma
BACKGROUND: When Staphylococcus aureus is grown in the presence of high concentration of external glucose, this sugar is phosphorylated by glucokinase (glkA) to form glucose-6-phosphate. This product subsequently enters into anabolic phase, which favors biofilm formation. The presence of ROK (repressor protein, open reading frame, sugar kinase) motif, phosphate-1 and -2 sites, and tyrosine kinase sites in glkA of S. aureus indicates that phosphorylation must regulate the glkA activity...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27664137/the-role-of-long-non-coding-rnas-in-ovarian-cancer
#15
Elahe Nikpayam, Behnoosh Tasharrofi, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard
Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified some suitable biomarkers to facilitate the early detection, the prognosis evaluation, and the assessment of treatment response. However, the aim of this review is to investigate the role of long non-coding RNAs (lncRNAs) in tumorigenesis process of ovarian cancer and their potential applications as ovarian cancer biomarkers...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27592363/in-silico-screening-and-evaluation-of-the-anticonvulsant-activity-of-docosahexaenoic-acid-like-molecules-in-experimental-models-of-seizures
#16
Ali Gharibi Loron, Soroush Sardari, Jamshid Narenjkar, Mohammad Sayyah
BACKGROUND: Resistance to antiepileptic drugs and the intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA) make it as a good candidate for designing and development of the new anticonvulsant medications. METHODS: Ten DHA-based molecules were screened based on in silico screening of DHA-like molecules by root-mean-square deviation of atomic positions, the biological activity score of Professional Association for SQL Server, and structural requirements suggested by pharmacophore design...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27432784/screening-of-alginate-lyase-producing-bacteria-and-optimization-of-media-compositions-for-extracellular-alginate-lyase-production
#17
Hadis Tavafi, Ahya Abdi-Ali, Parinaz Ghadam, Sara Gharavi
BACKGROUND: Alginate is a linear polysaccharide consisting of guluronate (polyG) and mannuronate (polyM) subunits. METHODS: In the initial screening of alginate-degrading bacteria from soil, 10 isolates were able to grow on minimal medium containing alginate. The optimization of cell growth and alginate lyase (algL) production was carried out by the addition of 0.8% alginate and 0.2-0.3 M NaCl to the culture medium. Of 10 isolates, one was selected based on its fast growth rate on minimal 9 medium containing 0...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27432735/investigation-of-microrna-21-expression-levels-in-serum-and-stool-as-a-potential-non-invasive-biomarker-for-diagnosis-of-colorectal-cancer
#18
Saiyad Bastaminejad, Morovat Taherikalani, Reza Ghanbari, Akbar Akbari, Nooshin Shabab, Massoud Saidijam
BACKGROUND: Most cancer studies focus on exploring non-invasive biomarkers for cancer detection. In the present study, we sought to investigate the expression level of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal cancer (CRC) and 40 healthy controls. METHODS: Quantitative real-time RT-PCR was applied to determine the relative expression level of miR-21 in serum and stool. At the same time, the sensitivity and specificity of this marker was evaluated by receiver operating characteristic (ROC) curve analysis...
2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27432596/methylation-status-of-h19-igf2-differentially-methylated-region-in-in-vitro-human-blastocysts-donated-by-healthy-couples
#19
Marzieh Derakhshan-Horeh, Farid Abolhassani, Farnoosh Jafarpour, Ashraf Moini, Khadijeh Karbalaie, Sayyed Morteza Hosseini, Somayyeh Ostadhosseini, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Imprinted genes are a unique subset of few genes that have been differentially methylated region (DMR) in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies have shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception micro-environments often is occurred by assisted reproduction techniques (ART). This study investigated the methylation status of H19/IGF2 DMR at high-quality expanding/expanded human blastocysts donated by healthy individuals to evaluate the risks linked to ART...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27238935/association-of-abcb1-c3435t-and-abcc1-g2012t-polymorphisms-with-clinical-response-to-atorvastatin-in-iranian-patients-with-primary-hyperlipidemia
#20
Niusha Behdad, Javad Kojuri, Negar Azarpira, Amir Masoomi, Soha Namazi
BACKGROUND: Atorvastatin is prescribed for the primary and the secondary prevention of coronary artery diseases. A wide variation in inter-individual statin response suggests that genetic differences may contribute to this variation. This study investigated the association of ABCB1 (C3435T) and ABCC1 (G2012T) polymorphisms with clinical response to atorvastatin in Iranian primary hyperlipidemic patients. METHODS: Individuals (n=179) with primary hypercholesterolemia were enrolled, and peripheral blood samples were collected...
2017: Iranian Biomedical Journal
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