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Iranian Biomedical Journal

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https://www.readbyqxmd.com/read/27874107/the-effect-of-oral-consumption-of-probiotics-in-prevention-of-heart-injury-in-a-rat-myocardial-infarction-model-a-histopathological-hemodynamic-and-biochemical-evaluation
#1
Jafar Sadeghzadeh, Abedin Vakili, Hamid Reza Sameni, Mahdi Shadnoush, Ahmad-Reza Bandegi, Mahdi Zahedi Khorasani
BACKGROUND: Despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. METHODS: Four viable probiotics bacterial strains, including Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus and Lactobacillus acidophilus, at the concentrations of 2×106 colony-forming units/ml were orally administered to the rats daily for 14 days before the induction of infarct-like myocardial injury using isoproterenol...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27874106/is-leukocyte-telomere-length-related-with-lung-cancer-risk-a-meta-analysis
#2
Behrooz Karimi, Masud Yunesian, Ramin Nabizadeh, Parvin Mehdipour, Afsaneh Aghaie
BACKGROUND: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. METHODS: A systematic search was carried out using PubMed, EMBASE, and ISI before 2015...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27869251/an-increased-genotoxic-risk-in-lymphocytes-from-phototherapy-treated-hyperbilirubinemic-neonates
#3
Seyed Alireza Mesbah-Namin, Maryam Shahidi, Maryam Nakhshab
BACKGROUND: Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. METHODS: Newborns were divided into three groups, including phototherapy-treated (PT, n=30) jaundiced newborns with total serum bilirubin (TSB) levels >15 mg/dl, non-treated jaundiced newborns (C+, n=27), as positive, as well as healthy negative (C-, n=30) controls with TSB levels ranging from 10 and 15 mg/dl and less than 5 mg/dl, respectively...
November 21, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27805073/comparing-anti-hepatitis-b-antibody-level-in-iranian-obese-or-overweight-with-non-obese-cases
#4
Ali Kabir, Abdolreza Pazouki, Motahareh Jafari, Somayye Mokhber, Mohammad Vaziri, Seyed Moayed Alavian
BACKGROUND: There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. METHODS: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran. RESULTS: Obese cases had lower percentage of liver diseases (66...
November 2, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27805072/evaluation-of-an-albumin-binding-domain-protein-fused-to-recombinant-human-il-2-and-its-effects-on-the-bioactivity-and-serum-half-life-of-the-cytokine
#5
Elham Adabi, Fateme Saebi, Amin Moradi Hasan-Abad, Ladan Teimoori-Toolabi, Gholam Ali Kardar
BACKGROUND: Background: Cancer immunotherapy is a promising strategy for cancer treatment. In this strategy, the immune system is triggered to destroy cancer cells. IL-2 is an important factor in passive cancer immunotherapy that helps modulating some important immune functions. One of the IL-2 limitations is low serum half-life; therefore, repetitive high doses of the injections are required to maintain effective concentrations. High-dose IL-2 therapy results in severe side effects; thus, improvement of its serum half-life would provide therapeutic benefits...
November 2, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27794585/a-novel-defensin-like-peptide-associated-with-two-other-new-cationic-antimicrobial-peptides-in-transcriptome-of-the-iranian-scorpion-venom
#6
Masoumeh Baradaran, Amir Jalali, Maryam Naderi Soorki, Hamid Galehdari
INTRODUCTION: Scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (AMPs) have been found in the venom gland of scorpions. Therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. Here, we describe three new cationic AMPs, including meuVAP-6, meuAP-18-1, and meuPep34 from the venom gland of the Iranian scorpion, Mesobuthus eupeus. METHODS: The cDNA sequences encoding all the three peptides were obtained from the cDNA library of scorpion venom gland and were deposited in the GenBank database...
October 30, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27752182/introducing-a-new-experimental-islet-transplantation-model-using-biomimetic-hydrogel-and-a-simple-high-yield-islet-isolation-technique
#7
Jamal Mohammadi Ayenehdeh, Bahareh Niknam, Seyed Mahmoud Hashemi, Hossein Rahavi, Nima Rezaei, Masoud Soleimani, Nader Tajik
BACKGROUND: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functional islets and transplantation are crucial. METHODS: The present study has introduced an experimental model that overcomes some critical issues in islet transplantation, including in situ pancreas perfusion by digestive enzymes through common bile duct...
October 18, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27703278/ghrelin-exerts-analgesic-effects-through-modulation-of-il-10-and-tgf-%C3%AE-levels-in-a-rat-model-of-inflammatory-pain
#8
Faranak Azizzadeh, Javad Mahmoodi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Gisou Mohaddes
BACKGROUND: Ghrelin is a peptide with attenuating effect on inflammatory pain. Both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. IL-10 and TGF-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. In this study, the effects of i.p. injection of ghrelin on the early and the late phases of pain, as well as serum levels of IL-10 and TGF-β, as anti-inflammatory cytokines, were investigated in formalin-induced pain in male rats...
October 5, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27695030/phosphorylation-of-staphylococcus-aureus-protein-tyrosine-kinase-affects-the-function-of-glucokinase-and-biofilm-formation
#9
Dudipeta Vasu, Pasupuleti Santhosh Kumar, Uppu Venkateswara Prasad, Vimjam Swarupa, Sthanikam Yeswanth, Lokanathan Srikanth, Manne Mudhu Sunitha, Abhijith Choudhary, Potukuchi Venkata Gurunadha Krishna Sarma
BACKGROUND: When Staphylococcus aureus is grown in the presence of high concentration of external glucose, this sugar is phosphorylated by glucokinase (glkA) to form glucose-6-phosphate. This product subsequently enters into anabolic phase, which favors biofilm formation. The presence of ROK (repressor protein, open reading frame, sugar kinase) motif, phosphate-1 and -2 sites, and tyrosine kinase sites in glkA of S. aureus indicates that phosphorylation must regulate the glkA activity...
October 1, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27677314/serum-antibodies-against-helicobacter-pylori-neutrophil-activating-protein-in-carriers-of-il-4-c-590t-genetic-polymorphism-amplify-the-risk-of-gastritis-and-gastric-cancer
#10
Yeganeh Talebkhan, Mohsen Doozbakhshan, Samaneh Saberi, Maryam Esmaeili, Najmeh Karami, Nazanin Mohajerani, Afshin Abdirad, Mahmoud Eshagh Hosseini, Azin Nahvijou, Mohammad Ali Mohagheghi, Marjan Mohammadi
BACKGROUND: Gastric cancer arises, mainly, on an inflammatory background. Helicobacter pylori neutrophil activating (HP-NAP) protein functions as a potent pro-inflammatory mediator. Similarly, IL-4 plays a critical role in the inflammation pathway, the levels of which are altered by C to T transition at position -590 in its promoter region. Here, we have aimed to assess the risk of gastritis and gastric cancer in the co-presence of these two inflammation modulating mediators. METHODS: Gastritis (n=58) and gastric cancer (n=31) patients were evaluated and compared with H...
September 28, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27664137/the-role-of-long-non-coding-rnas-in-ovarian-cancer
#11
Elahe Nikpayam, Behnoosh Tasharrofi, Shaghayegh Sarrafzadeh, Soudeh Ghafouri-Fard
Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified some suitable biomarkers to facilitate the early detection, the prognosis evaluation, and the assessment of treatment response. However, the aim of this review is to investigate the role of long non-coding RNAs (lncRNAs) in tumorigenesis process of ovarian cancer and their potential applications as ovarian cancer biomarkers...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27432596/methylation-status-of-h19-igf2-differentially-methylated-region-in-in-vitro-human-blastocysts-donated-by-healthy-couples
#12
Marzieh Derakhshan-Horeh, Farid Abolhassani, Farnoosh Jafarpour, Ashraf Moini, Khadijeh Karbalaie, Sayyed Morteza Hosseini, Somayyeh Ostadhosseini, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Imprinted genes are a unique subset of few genes that have been differentially methylated region (DMR) in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies have shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception micro-environments often is occurred by assisted reproduction techniques (ART). This study investigated the methylation status of H19/IGF2 DMR at high-quality expanding/expanded human blastocysts donated by healthy individuals to evaluate the risks linked to ART...
January 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27594443/venom-components-of-iranian-scorpion-hemiscorpius-lepturus-inhibit-the-growth-and-replication-of-human-immunodeficiency-virus-1-hiv-1
#13
Rezvan Zabihollahi1, Kamran Pooshang Bagheri, Zohreh Keshavarz, Fatemeh Motevalli, Golnaz Bahramali, Seyed Davar Siadat, Seyed Bahman Momen, Delavar Shahbazzadeh, Mohammad Reza Aghasadeghi
BACKGROUND: During the recent years, significant progress has been achieved on development of novel anti-viral drugs. Natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. Based on the significant value for tracing of non-toxic anti-viral agents from natural resources, this study was aimed to investigate the anti-viral activity of some HPLC purified fractions derived from the venom of Iranian scorpion, Hemiscorpius lepturus, against human immunodeficiency virus 1 (HIV-1) and herpes simplex virus 1 (HSV-1)...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27452399/whole-exome-sequencing-reveals-a-bscl2-mutation-causing-progressive-encephalopathy-with-lipodystrophy-peld-in-an-iranian-pediatric-patient
#14
Mohammad Reza Alaei, Saeed Talebi, Mohammad Ghofrani, Mohsen Taghizadeh, Mohammad Keramatipour
BACKGROUND: Progressive encephalopathy with or without lipodystrophy is a rare autosomal recessive childhood-onset seipin-associated neurodegenerative syndrome, leading to developmental regression of motor and cognitive skills. In this study, we introduce a patient with developmental regression and autism. The causative mutation was found by exome sequencing. METHODS: The proband showed a generalized hypertonia and regression of all developmental milestones. Based on the advantages of next-generation sequencing (NGS), whole exome sequencing (WES) was requested...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27377127/role-of-epigenetics-in-biology-and-human-diseases
#15
Azam Moosavi, Ali Motevalizadeh Ardekani
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurodegenerative and psychological disorders. This review first explains the history and classification of epigenetic modifications, and then the role of epigenetic in biology and connection between the epigenetics and environment are explained...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27221523/minocycline-effects-on-il-6-concentration-in-macrophage-and-microglial-cells-in-a-rat-model-of-neuropathic-pain
#16
Taraneh Moini-Zanjani, Seyed-Nasser Ostad, Farzaneh Labibi, Haleh Ameli, Nariman Mosaffa, Masoumeh Sabetkasaei
BACKGROUND: Evidence indicates that neuropathic pain pathogenesis is not confined to changes in the activity of neuronal systems but involves interactions between neurons, inflammatory immune and immune-like glial cells. Substances released from immune cells during inflammation play an important role in development and maintenance of neuropathic pain. It has been found that minocycline suppresses the development of neuropathic pain. Here, we evaluated the analgesic effect of minocycline in a chronic constriction injury (CCI) model of neuropathic pain in rat and assessed IL-6 concentration from cultured macrophage and microglia cells...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27137790/epidemiology-of-rotavirus-norovirus-co-infection-and-determination-of-norovirus-genogrouping-among-children-with-acute-gastroenteritis-in-tehran-iran
#17
Seyed Dawood Mousavi Nasab, Farzaneh Sabahi, Manoochehr Makvandi, Siamak Mirab Samiee, Seyed Alireza Nadji, Mehrdad Ravanshad
BACKGROUND: Enteric viruses, particularly human rotavirus and norovirus, have been shown to replace bacteria and parasites, as the most common pathogens responsible for acute diarrhea. However, there are still few epidemiological data on the simultaneous occurrence of these viruses in Iran. In this regard, the aim of this study was to assess the useful epidemiological data on the gastroenteritis associated with rotavirus-norovirus mixed infection and to examine the prevalence of norovirus genogrouping among children aged less than five years old in Iran...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27108691/facilitation-of-hippocampal-kindling-and-exacerbation-of-kindled-seizures-by-intra-ca1-injection-of-quinine-a-possible-role-of-cx36-gap-junctions
#18
Fatemeh Etemadi, Mohammad Sayyah, Hamid Gholami Pourbadie, Vahab Babapour
BACKGROUND: GABAergic interneurons in the hippocampal CA1 area are mutually communicated by gap junctions (GJs) composed of connexin36 (Cx36). We examined the role of Cx36 in CA1 in manifestation of kindled seizures and hippocampal kindling in rats. METHODS: Quinine, as the specific blocker of Cx36, was injected into CA1, and kindled seizures severity was examined 10 min afterward. Moreover, quinine was injected into CA1 once daily, and the rate of CA1 kindling was recorded...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/26975327/demonstration-of-herpes-simplex-virus-cytomegalovirus-and-epstein-barr-virus-in-colorectal-cancer
#19
Sahar Mehrabani-Khasraghi, Mitra Ameli, Farzad Khalily
BACKGROUND: The present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in CRC and colorectal polyp by using the PCR method in Iran. METHODS: In this analytical case-control study, we selected 15 patients with CRC, 20 patients with colorectal polyp, and 35 patients without malignancy as controls. After DNA extraction, PCR was used to determine HSV, CMV, and EBV genome by specific primers...
November 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27592363/in-silico-screening-and-evaluation-of-the-anticonvulsant-activity-of-docosahexaenoic-acid-like-molecules-in-experimental-models-of-seizures
#20
Ali Gharibi Loron, Soroush Sardari, Jamshid Narenjkar, Mohammad Sayyah
BACKGROUND: Resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA), make it as a good candidate for designing and development of the new anticonvulsant medications. METHODS: Ten DHA-based molecules were screened based on in silico screening of DHA-like molecules by root-mean-square deviation of atomic positions, biological activity score of Professional Association for SQL Server and structural requirements suggested by pharmacophore design...
September 4, 2016: Iranian Biomedical Journal
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