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Iranian Biomedical Journal

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https://www.readbyqxmd.com/read/28627158/evaluation-of-serum-interleukin-21-and-hla-c1-polymorphism-in-pediatrician-hematopoietic-stem-cell-transplantation-for-early-diagnosis-of-acute-graft-versus-host-disease
#1
N Sehati, P Kokhaei, A Motevalizade Ardekani, R Tootoonchian, F Pak
Background: Allogenic hematopoietic stem cell transplantation (HSCT) is a strategy used for treatment of different malignant diseases. However, success of allo-HSCT can be hampered by graft-versus-host-disease (GVHD). Natural killer (NK) cells may play an important role in activating antigen presenting cells and subsequent activation of T cells. The main purpose of this study was the evaluation of IL-21, as a blood biomarker, for early detection of acute GVHD (aGVHD) in children after HSCT and also the study of human leukocytes antigen (HLA)-C1 polymorphism, as a targeting ligand for NK cells in these patients...
June 19, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28605892/improvement-of-thermal-stability-of-bcg-vaccine
#2
Fatemeh Jahanbakhsh Sefidi, Homan Kaghazian, Gholam Ali Moradli, Seyed Mehdi Hassanzadeh
BAckground: Thermal stability (TS) is a part of the BCG vaccine characterization by which consistency of process in BCG vaccine production could be confirmed. To enhance the TS of the vaccine, some prevalent stabilizers in different concentration were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer for retaining the higher viability of lyophilized BCG vaccine produced by Pasteur Institute of Iran...
June 13, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28601058/in-vitro-study-of-spions-c595-as-molecular-imaging-probe-for-specific-breast-cancer-mcf-7-cells-detection
#3
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Amin Malik Shah Abdul Majid, Mohammad Suhaimi Jaafar, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanoparticles was confirmed using X-ray diffraction, transmission electron microscopy, and photon correlation spectroscopy...
June 11, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28558440/chemical-composition-and-antimicrobial-activities-of-iranian-propolis
#4
Houshang Afrouzan, Tahghighi Azar, Sedigheh Zakeri, Es-haghi Ali
Background: With considering the importance of natural products for their remedial and therapeutic value, this research was aimed to analyze the chemical compositions and antimicrobial activity of four propolis samples from different areas of Iran (Chenaran, Taleghan, Morad Beyg, and Kalaleh) with various climates and flora. Methods: ethanolic (70% EtOH) and dichlromethane (DCM) extracts of Iranian propolis were analyzed by gas chromatography-mass spectrometry (GC-MS) methods, and antimicrobial activity was evaluated against Candida albicans, Escherichia coli, and Staphylococcus aureus using disk diffusion antimicrobial method...
May 31, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28558439/accuracy-of-soluble-endoglin-for-diagnosis-of-preeclampsia-and-its-severity
#5
Pooneh Nikuei, Minoo Rajaei, Kianoosh Malekzadeh, Azim Nejatizadeh, Fatemeh Mohseni, Ali AtashAbParvar
Background: The use of biomarkers for diagnosis of Preeclampsia (PE), a life-threatening pregnancy disorder, could reduce serious complications of this disease. In this study, we investigated dysregulation of endoglin (Eng) expression and diagnostic accuracy of soluble endoglin (sEng) in PE patients. Methods: For this case-control study, 26 mild and 15 severe preeclamptic women along with 20 normotensive controls were recruited. The expression level of Eng (the co-receptor of TGF-β1) was evaluated using qRT-PCR...
May 31, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28558438/accuracy-of-soluble-endoglin-for-diagnosis-of-preeclampsia-and-its-severity
#6
Pooneh Nikuei, Minoo Rajaei, Kianoosh Malekzadeh, Azim Nejatizadeh, Fatemeh Mohseni, Ali AtashAbParvar
Background: The use of biomarkers for diagnosis of Preeclampsia (PE), a life-threatening pregnancy disorder, could reduce serious complications of this disease. In this study, we investigated dysregulation of endoglin (Eng) expression and diagnostic accuracy of soluble endoglin (sEng) in PE patients. Methods: For this case-control study, 26 mild and 15 severe preeclamptic women along with 20 normotensive controls were recruited. The expression level of Eng (the co-receptor TGF-β1) was evaluated using qRT-PCR...
May 31, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28558437/precision-medicine-a-new-revolution-in-healthcare-system
#7
Babak Arjmand, Mohammad Abdollahi, Bagher Larijani
Every human being is different based on genetics, lifestyle, and environmental factors. Novel medical technologies have become more precise owing to molecular information, including genomics, transcriptomics, proteomics, metabolomics, etc. The “omics” technologies have opened up new horizons for healthcare systems, enabling them to prevent and/or diagnose diseases more precisely, as well as to find the most effective treatments with fewer adverse events. Recently, the term ‘precision medicine’ (PM), focusing on molecular-based medicine, has been introduced...
May 31, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28555492/equilibrium-isotherm-kinetic-modeling-optimization-and-characterization-studies-of-cadmium-adsorption-by-surface-engineered-escherichia-coli
#8
Vida Tafakori, Reza Zadmard, Fatemeh Tabandeh, Mohammad Ali Amoozegar, Gholamreza Ahamadian
Background: Amongst the methods that remove heavy metals from environment, biosorption approaches have received increased attention because of their environmentally friendly and cost-effective feature, as well as their superior performances. Methods: In the present study, we investigated the ability of a surface-engineered Escherichia coli, carrying the cyanobacterial metallothionein on the cell surface, in the removal of Ca (II) from solution under different experimental conditions...
May 30, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28551944/misconduct-in-research-and-publication
#9
LETTER
Viroj Wiwanitkit
Dear Editor, I read the recent publication on “Misconduct in Research and Publication” with great interest[1]. I agree that misconduct in research and publication is not uncommon. Nevertheless, it is rarely mentioned. In fact, there are many incorrect conceptions among researchers on publication ethics. The milder examples are attempts to report only the “positive outcomes”, textual or data recycling as well as figure cropping and modification. These problems can be seen in published work of many academic members regardless of nationality or seniority...
May 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28532144/physically-targeted-intravenous-polyurethane-nanoparticles-for-controlled-release-of-atorvastatin-calcium
#10
Behnaz Sadat Eftekhari, Akbar Karkhaneh, Ali Alizadeh
Background: Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane (PU) nanoparticles were investigated for intravenous route of administration. Methods: First, PU was synthesized and characterized. Second, nanoparticles were prepared in four different ratios of drug to polymer through two different techniques including emulsion-diffusion and single-emulsion...
May 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28480695/expression-study-and-clinical-correlations-of-myc-and-ccat2-in-breast-cancer-patients
#11
Shaghayegh Sarrafzadeh, Lobat Geranpayeh, Behnoosh Tasharrofi, Mohammad Soudyab, Elahe Nikpayam, Mostafa Iranpour, Reza Mirfakhraie, Jalal Gharesouran, Somayyeh Ghafouri-Fard, Soudeh Ghafouri-Fard
Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated the expression of CCAT2 in breast cancer tissues with regards to the expression of its target MYC...
May 8, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28460491/homozygosity-mapping-and-targeted-sanger-sequencing-identifies-three-novel-crb1-crumbs-homologue-1-mutations-in-iranian-retinal-degeneration-families
#12
Mohammad Ghofrani, Mahin Yahyaei, Han G. Brunner, Frans P.M. Cremers, Morteza Movasat, Muhammad Imran Khan, Mohammad Keramatipour
Background: Inherited retinal diseases (IRDs) are a group of genetic disorders with high degrees of clinical, genetic and allelic heterogeneity. IRDs generally show progressive retinal cell death resulting in gradual vision loss. IRDs constitute a broad spectrum of disorders including retinitis pigmentosa and Leber congenital amaurosis. In this study, we performed genotyping studies to identify the underlying mutations in three Iranian families. Method: Having employed homozygosity mapping and Sanger sequencing, we identified the underlying mutations in the crumbs homologue 1 gene...
May 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28460428/e6-specific-detection-and-typing-of-human-papillomaviruses-in-oral-cavity-specimens-from-iranian-patients
#13
Hadi Razavi Nikoo, Abdollah Ardebili, Mehrdad Ravanshad, Fatemeh Rezaei, Ali Teimoori, Sayyad Khanizadeh, Mohammad Hassan Pouriayevali, Mehdi Ajorloo
Background: Detection and quantification of human Papillomavirus (HPV) genome in oral carcinoma plays an important role in diagnosis, as well as implications for progression of disease. Methods: We evaluated tissues from 50 esopharyngeal cancers collected from different regions of Iran for HPV E6 using the two type-specific primers sets. E6 gene of HPV genotypes was amplified by specific primers. The sensitivity of PCR assay was analyzed and determined using HPV-DNA-containing plasmids...
May 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28459147/synergistic-effects-of-arsenic-trioxide-and-radiation-triggering-of-intrinsic-pathway-of-apoptosis
#14
Kave Moloudi, Ali Neshasteriz, Arshad Hosseini, Nazila Eyvazzadeh, Mehdi Shomali, Samira Eynali, Elahe Mirzaei, Asaad Azarnezhad
Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some cancers. The aim of this study is to determine the underlying apoptosis molecular and cellular mechanisms of ATO in the presence or absence of ionizing radiation (IR) in vitro in the glioblastoma multiforme (GBM) cell line, U87MG. Methods: Cells were treated by different concentrations of ATO either in presence or absence of IR...
May 1, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#15
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28433004/plackett-burman-design-and-response-surface-optimization-of-medium-trace-nutrients-for-glycolipopeptide-biosurfactant-production
#16
Maurice George Ekpenyong, Sylvester Peter Antai, Atim David Asitok, Bassey Offiong Ekpo
Background: A glycolipopeptide biosurfactant produced by Pseudomonas aeruginosa strain IKW1 reduced the surface tension of fermentation broth from 71.31 to 24.62 dynes/cm at a critical micelle concentration of 20.80 mg/L. The compound proved suitable for applications in emulsion stabilization in food, as well as in cosmetic and pharmaceutical formulations. Method: In the present study, Plackett-Burman design (PBD) and response surface method (RSM) were employed to screen and optimize concentrations of trace nutrients in the fermentation medium, to increase surfactant yield...
April 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28431466/next-generation-sequencing-reveals-one-novel-missense-mutation-in-col1a2-gene-in-an-iranian-family-with-osteogenesis-imperfecta
#17
Farah Talebi, Farideh Ghanbari Mardasi, Mohammadi Asl Javad, Bavarsad Amir Hooshang, Salehi Kambo Masoumeh
BAckground: Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder characterized by bone loss and bone fragility. The aim of this study was to investigate the variants of three genes involved in the pathogenesis of OI. Methods: Molecular genetic analyses were performed for COL1A1, COL1A2, and CRTAP genes in an Iranian family with OI. The DNA samples were analyzed by next-generation sequencing (NGS) gene panel and Sanger sequencing. Results: Five different variants were identified in COL1A1 and COL1A2, including two variants in COL1A1 and three variants in COL1A2...
April 22, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28415833/molecular-characterization-and-biodiversity-of-a-putative-chlorotoxin-from-the-iranian-yellow-scorpion-odontobuthus-doriae
#18
Maryam Naderi Soorki, Amir Jalali, Hamid Galehdari
BAckground: Chloride channels have already been over-expressed in the different types of cancer. Chlorotoxins, as the blocking agent of these channels, have been indicated to be an effective drug against tumors. In this study, we characterized a putative chlorotoxin from a cDNA library of the venom glands obtained from the Iranian scorpion Odontobuthus doriae. Methods: A cDNA library was constructed from venom gland transcriptome of six scorpions. The cDNA encoding Odontobuthus doriae chlorotoxin was isolated from the library, and its putative peptide was characterized by some bioinformatics software such as protein blast, SignalP4...
April 18, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28410549/evaluation-of-factors-influencing-antibody-reduction-for-development-of-antibody-drug-conjugates
#19
Meghdad Abdollahpour-Alitappeh, Majid Lotfinia, Sepand Razavi-Vakhshourpour, Saeed Jahandideh, Hamid Najminejad, Koushan Sineh Sepehr, Reza Moazami, Elnaz Shams, Mahdi Habibi-Anbouhi, Mohsen Abolhassani
Background: Reduction/alkylation is one of the leading strategies for the development of antibody drug conjugates (ADCs). Precise control of the reduction process would not only yield a defined number of free thiols per antibody but also result in development of more homogenous conjugates. Methods: In the present study, we investigated the effect of various dithiothreitol (DTT) concentrations, temperature conditions, and DTT exposure times on antibody reduction...
April 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28525954/construction-of-various-%C3%AE-34-5-deleted-fluorescent-expressing-oncolytic-herpes-simplex-type-1-ohsv-for-generation-and-isolation-of-hsv-based-vectors
#20
Shahriyar Abdoli, Farzin Roohvand, Ladan Teimoori-Toolabi, Mohammad Ali Shokrgozar, Mina Bahrololoumi, Kayhan Azadmanesh
Background: Oncolytic herpes simplex virus (oHSV)-based vectors lacking γ34.5 gene, are considered as ideal templates to construct efficient vectors for (targeted) cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and γ34.5-deleted, recombinant HSV-1 vectors for rapid generation and easy selection/isolation of different HSV-Based vectors. Methods: Generation of recombinant viruses was performed with conventional homologous recombination methods using green fluorescent protein (GFP) and BleCherry harboring shuttle vectors...
July 2017: Iranian Biomedical Journal
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