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Iranian Biomedical Journal

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https://www.readbyqxmd.com/read/29034676/lipid-peroxidation-and-its-role-in-the-expression-of-nlrp1a-and-nlrp3-genes-in-testicular-tissue-of-male-rats-a-model-of-spinal-cord-injury
#1
Mahshid Bazrafkan, Banafsheh Nikmehr, Abdolhossein Shahverdi, Seyed Reza Hosseini, Fatemeh Hassani, Mahnaz Poorhassan, Tahmineh Mokhtari, Farid Abolhassani, Hamid Choobineh, Cordian Beyer, Gholamreza Hassanzadeh
BAckground: The majority of male patients with spinal cord injury (SCI) suffer from infertility. Nucleotide-binding oligomerization domain-like receptors NOD-like receptors (NLRs) are a kind of receptors that corporate in the inflammasome complex. Recent studies have introduced the inflammasome as the responsible agent for secreting cytokines in semen. Reactive oxygen species (ROS) is one of the elements that trigger inflammasome activation. Genital infections in SCI can lead to ROS generation...
October 16, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29031245/decrease-in-cavity-size-and-oligodendrocyte-cell-death-using-neurosphere-derived-oligodendrocyte-like-cells-in-spinal-cord-contusion-model
#2
Hojjat Allah Abbaszadeh, Taki Tiraihi, Yousef Sadeghi, Ali Reza Delshad, Majid Sadeghizadeh, Taher Taheri, Ali Noori-Zadeh
Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes is progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to counterbalance this condition. Methods: Bone marrow stromal cells were transdifferentiated into neurospheres and then into neural stem cells and later were differentiated into OLCs using triiodothyronine and transplanted into the spinal cord contusion rats...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29031244/development-of-new-recombinant-dgk-antigen-for-diagnosis-of-dirofilaria-immitis-infections-in-dogs-using-elisa-technique-and-its-comparison-to-molecular-methods
#3
Rahmat Solgi, Seyed Mahmoud Sadjjadi, Mehdi Mohebali, Zabihollah Zarei, Majid Golkar, Abbasali Raz
Background: Dirofilaria immitis is a cosmopolitan zoonotic, vector-borne parasite of carnivorous animals causing dirofilariasis in human beings. Common commercial serodiagnostic tests for canine dirofilariasis usually lead to different results in their sensitivity and specificity. The present study reports development of recombinant DgK (rDgK) antigen of D. immitis for accurate immunodiagnosis of D. Immitis-infected dogs using indirect ELISA test. Methods: The rDgK coding sequence was successfully sequenced, codon optimized and cloned in pET-24a(+) expression vector and then expressed in Escherichia coli...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29031243/preparation-and-evaluation-of-rifampicin-and-co-trimoxazole-loaded-nanocarrier-against-brucella-melitensis-infection
#4
Narges Bodaghabadi, Samira Hajigholami, Ziba Vaise Malekshahi, Maliheh Entezari, Farhood Najafi, Hadi Shirzad, Majid Sadeghizadeh
Background: Brucellosis or Malta fever is a contagious infection common between human and domestic animals. Many antibiotics are used for brucellosis treatment, but they are not efficient and put heavy burden on society. Co-trimoxazole and rifampicin are two candidates for brucellosis treatment. In this study, we aimed to enhance the efficacy of these antibiotics using designed nanoparticles. Methods: Different concentrations of co-trimoxazole and rifampicin were used for loading onto a nanostructure of synthesized monomethoxy poly(ethylene glycol)-oleate (mPEG-OA)...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28992682/nanocurcumin-mediated-down-regulation-of-telomerase-via-stimulating-tgf%C3%AE-1-signaling-pathway-in-hepatocellular-carcinoma-cells
#5
Molood Shariati, Samira Hajigholami, Ziba Veisi Malekshahi, Maliheh Entezari, Narges Bodaghabadi, Majid Sadeghizadeh
Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and Transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGFβ1 pathway in a hepatocellular carcinoma cell line (Huh7). Methods: MTT assay was used to determine the effect of nonocurcumin on viability of Huh7 cells...
October 10, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28992681/ofatumumab-monoclonal-antibody-affinity-maturation-through-in-silico-modeling
#6
Zahra Payandeh, Masoumeh Rajabibazl, Yousef Mortazavi, Azam Rahim-Pour, Amir Hossein Taromchi
Background: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody-dependent phagocytosis by macrophages. Apoptosis induction is another mechanism of this antibody. Computational docking is the method of predicting the conformation of an antibody-antigen from its separated elements...
October 10, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28952291/high-resolution-hla-a-typing-in-normal-iranian-population
#7
Azadeh Hadadianpour, Mohammad Hasan Samiee Aref, Sirous Zeinali
Background: Human leukocyte antigen (HLA) gene is a highly polymorphic region. HLA typing is required to match patients and donors for transplantation; therefore, development of HLA registries is necessary for finding HLA match donors. HLA system is highly informative, and numerous studies have been conducted on HLA allele distribution in different populations. Methods: In this study, 100 unrelated Iranian individuals were typed for HLA-A locus using sequence-based typing method...
September 27, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28941453/development-of-a-dna-aptamer-for-screening-neisseria-meningitidis-serogroup-b-by-cell-selex
#8
Kimia Mirzakhani, Seyed Latif Mousavi Gargari, Iraj Rasooli, Samaneh Rasoulinejad
Background: Artificial oligonucleotides like DNA or RNA aptamers can be used as biodiagnostic alternatives for antibodies to detect pathogens. Comparing to antibodies, artificial oligonucleotides are produced easily at lower costs and are more stable. Neisseria meningitidis, the causative agent of meningitis, is responsible for about 1% of infections in an epidemic period. Specific DNA aptamers that bind to N. meningitidis serogroup B were identified by whole-cell Systemic Evolution of Ligands by EXponential Enrichment (SELEX)...
September 24, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28915725/distribution-of-rotavirus-genotypes-ccirculating-in-ahvaz-iran-in-2016
#9
Azarakhsh Azaran, Manoochehr Makvandi, Ali Teimoori, Saeedeh Ebrahimi, Farzad Heydari, Roya Nikfar
Background: Group A rotavirus (RVA) mainly causes acute gastroenteritis, exclusively in young children in developing countries. The prevalence and determination of the molecular epidemiology of rotavirus genotypes will determine the dominant rotavirus genotypes in the region and provide a strategy for the development of appropriate vaccines. Methods: A total of 100 fecal samples were collected from children below five years with acute gastroenteritis who referred to Aboozar Children’s Hospital of Ahvaz city during October 2015 to March 2016...
September 16, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28870026/optogenetics-control-of-brain-using-light
#10
Hamid Gholami Pourbadie, Mohammad Sayyah
Neuronal cells communicate with each other by producing electrical signals or action potentials (APs). Different ion channels, including Na+, K+ and Ca2+ channels, are involved in generation of AP. Once an AP is generated in the soma, it travels down entire the axon length toward its terminal in a self-generating fashion that ultimately conveys information between neurons in the neural circuit. Depending on the neurotransmitter, each neuron inhibits or excites other neurons in a certain network. For instance, glutamate released from glutamatergic neurons, opens AMPA and NMDA channels permitting influx of Na+/Ca2+, which leads to postsynaptic depolarization...
September 5, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28865418/odf4-magea3-and-mageb4-potential-biomarkers-in-patients-with-transitional-cell-carcinoma
#11
Mandana Afsharpad, Mohammad Reza Nowroozi, Mohsen Ayati, Mojtaba Saffari, Saeed Nemati, Elham Mohebbi, Leila Nekoohesh, Kazem Zendehdel, Mohammad Hossein Modarressi
Background: This study aimed to evaluate the diagnostic value of outer dense fiber 4 (ODF4), melanoma-associated antigen A3 (MAGEA3), and MAGEAB4 mRNAs in transitional cell carcinoma (TCC), using a small amount of cell reverse transcriptase-polymerase chain reaction (RT-PCR) on urinary exfoliated cells. Methods: We recruited a total of 105 suspected TCC patients and 54 sex- and age-matched non-TCC controls. The candidates’ genetic expression patterns were investigated with RT-PCR, while reverse transcription quantitative PCR was applied to quantify and compare each mRNA level between cases and control groups...
September 3, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28806866/molecular-screening-and-single-nucleotide-polymorphism-typing-of-molluscum-contagiosum-virus-mcv-from-genital-specimens-between-2012-and-2015
#12
Sedigheh Taghinezhad-S, Amir Hossein Mohseni, Hossein Keyvani, Narges Ghobadi
Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2. Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Typing of the MCV-positive specimens was performed in the SNP A27451G region of MC021L gene...
August 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28806865/study-break-glucose-sensitive-holographic-bio-sensors-fundamentals-and-applications
#13
Marjan Heidari, Bahareh Dabirmanesh, Hossein Mahdavi, Khosro Khajeh
No abstract text is available yet for this article.
August 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28800701/a-new-indole-derivative-decreased-sall4-gene-expression-in-acute-promyelocytic-leukemia-cell-line-nb4
#14
Zahra Sheikhrezaei, Parisa Heydari, Alireza Farsinezhad, Ahmad Fatemi, Soudeh Khanamani Falahati-Pour, Shokoofeh Darakhshan, Mojgan Noroozi Karimabad, Ali Darekordi, Hossein Khorramdelazad, Gholamhossein Hassanshahi
Background: Acute myeloblastic leukemia (AML) is a clonal disorder due to bone marrow failure and uncontrolled proliferation of myeloid lineage. Acute promyelocytic leukemia (APL) is a subtype of AML. Heterocyclic compounds, such as indole, are considered as attractive candidates for cancer therapy, due to their abundance in nature and known biological activity. Sal-like protein (SALL4) is a zinc finger transcription factor involving in the multi-potency of stem cells, in the NB4 cell line...
August 12, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28766326/a-review-of-brucellosis-in-iran-epidemiology-risk-factors-diagnosis-control-and-prevention
#15
Maryam Golshani, Saeid Buozari
Brucellosis caused by species of Brucella is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination, which harbors significant disadvantages. Considering the identification of many immunogenic proteins in Brucella, several studies have recently been performed to evaluate the vaccine potency of such antigens as a new subunit vaccine candidate...
August 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28755654/effects-of-bone-marrow-mesenchymal-stem-cells-conditioned-medium-on-tibial-partial-osteotomy-model-of-fracture-healing-in-hypothyroidism-rats
#16
Niloofar Sefati, Mohsen Norouzian, Hojjat-Allah Abbaszadeh, Mohammad-Amin Abdollahifar, Abdollah Amini, Mohammad Bagheri, Arefeh Aryan, Fatemeh Fadaei Fathabady
Background: Hypothyroidism is associated with dysfunction of the bone turnover with reduced osteoblastic bone formation and osteoclastic bone resorption. Mesenchyme stem cells (MSCs) secrete various factors and cytokines that may stimulate bone regeneration. The aim of this study was to determine the effects of MSCs-conditioned medium (CM) in hypothyroidism male rats after inducing bone defect. Methods: : In this study, 24 male rats were randomly assigned to three groups: (I) hypothyroidism+bone defect (HYPO), (II) hypothyroidism+bone defect+CM (HYPO+CM), and (III) no hypothyroidism+bone defect (control)...
July 30, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734275/low-level-of-autophagy-related-gene-10-atg10-expression-in-the-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#17
Marzieh Shams Nooraei, Ali Noori-Zadeh, Shahram Darabi, Farzad Rajaei, Zohreh Golmohammadi, Hojjat Allah Abbaszadeh
Background: Autophagy is a mechanism disassembling the damaged organelles from the cell. This study attempted to examine the expression of several autophagy-related genes in Parkinson’s disease (PD) rat model. Methods: The male Wistar rats were divided into three groups as control, sham, and lesion. In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in the striatum.The behavioral test was conducted one (baseline) and four weeks after the surgery through apomorphine hydrochloride...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734274/genetic-analysis-of-iranian-patients-with-familial-hypercholesterolemia
#18
Mahdis Ekrami, Maryam Torabi, Soudeh Ghafouri-Fard, Javad Mowla, Bahram Mohammad Soltani, Feyzollah Hashemi-Gorji, Zahra Mohebbi, Mohammad Miryounesi
Background: Familial hypercholesterolemia (FH) is a frequent autosomal dominant disorder of lipoprotein metabolism. This disorder is generally caused by mutations in low-density lipoprotein receptor (LDLR), apolipoprotein B 100 (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. In the present study, we aimed at identifying the common LDLR and APOB gene mutations in an Iranian population. Methods: Eighty unrelated Iranian patients with FH entered the study, based on Simon Broome diagnostic criteria...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734273/association-between-thrombophilic-genes-polymorphisms-and-recurrent-pregnancy-loss-susceptibility-in-the-iranian-population-a-systematic-review-and-meta-analysis
#19
Mahdieh Kamali, Sedigheh Hantoushzadeh, Sedigheh Borna, Hossein Neamatzadeh, Mahta Mazaheri, Mahmood Noori-Shadkam, Fatemeh Haghighi
Background: Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. However, the results from these studies remained inconsistent and inconclusive. The aim of this systematic review and meta-analysis was to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. Method: Electronic databases of PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28755655/therapeutic-effects-of-iranian-herbal-extracts-against-trichomonas-vaginalis
#20
Zohreh Fakhrieh Kashan, Mahdi Delavari, Mohsen Arbabi, Hossein Hooshyar
Trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. Tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are FDA approved drugs recommended for trichomoniasis treatment. Treatment with metronidazole 5'-nitroimidazole derivatives is associated with many side effects, and drug resistance to metronidazole has been reported in some cases. Recently, many attempts have been made to evaluate the effects of plants on causative agents of vaginal infections...
September 2017: Iranian Biomedical Journal
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