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Pituitary

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https://www.readbyqxmd.com/read/28421421/sphenoid-sinus-mucosal-thickening-in-the-acute-phase-of-pituitary-apoplexy
#1
Mueez Waqar, Robert McCreary, Tara Kearney, Konstantina Karabatsou, Kanna K Gnanalingham
PURPOSE: In pituitary apoplexy (PA), there are preliminary reports on the appearance of sphenoid sinus mucosal thickening (SSMT). SSMT is otherwise uncommon with an incidence of up to 7% in asymptomatic individuals. The aim of this study was to evaluate the incidence and clinical significance of SSMT in patients with PA and a control group of surgically treated non-functioning pituitary adenomas (NFPAs). METHODS: Retrospective review of clinical and imaging variables in PA and NFPA patients...
April 18, 2017: Pituitary
https://www.readbyqxmd.com/read/28342098/expression-of-cell-cycle-regulators-and-biomarkers-of-proliferation-and-regrowth-in-human-pituitary-adenomas
#2
Mark Gruppetta, Robert Formosa, Sharon Falzon, Sabrina Ariff Scicluna, Edward Falzon, James Degeatano, Josanne Vassallo
PURPOSE: The pathogenesis of pituitary adenomas (PA) is complex. Ki-67, pituitary tumour transforming gene (PTTG), vascular endothelial growth factor (VEGF), cyclin D1, c-MYC and pituitary adenylate cyclase-activating peptide (PACAP) protein expression were analysed and correlated with tumour and patient characteristics. METHODS: 74 pituitary tumour samples (48 non-functional PA, 26 functional PAs); Immunohistochemical analysis of protein expression, retrospective analysis of MR images and in vitro analysis of octreotide treatment was carried out on GH3 cells...
March 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28332051/white-matter-involvement-on-dti-mri-in-cushing-s-syndrome-relates-to-mood-disturbances-and-processing-speed-a-case-control-study
#3
Patricia Pires, Alicia Santos, Yolanda Vives-Gilabert, Susan M Webb, Aitor Sainz-Ruiz, Eugenia Resmini, Iris Crespo, Manel de Juan-Delago, Beatriz Gómez-Anson
PURPOSE: Cushing's syndrome (CS) is an endocrine disorder due to prolonged exposure to cortisol. Recently, microstructural white matter (WM) alterations detected by diffusion tensor imaging (DTI) have been reported in CS patients, and related to depression, but other functional significances. remain otherwise unclear. We aimed at investigating in more depth mood symptoms in CS patients, and how these relate to cognition (information processing speed), and to WM alterations on DTI. METHODS: The sample comprised 35 CS patients and 35 healthy controls...
March 22, 2017: Pituitary
https://www.readbyqxmd.com/read/28275992/follow-up-intervals-in-patients-with-cushing-s-disease-recommendations-from-a-panel-of-experienced-pituitary-clinicians
#4
Eliza B Geer, Alejandro Ayala, Vivien Bonert, John D Carmichael, Murray B Gordon, Laurence Katznelson, Ekaterina Manuylova, Ismat Shafiq, Vijaya Surampudi, Ronald S Swerdloff, Michael S Broder, Dasha Cherepanov, Marianne Eagan, Jackie Lee, Qayyim Said, Maureen P Neary, Beverly M K Biller
PURPOSE: Follow-up guidelines are needed to assess quality of care and to ensure best long-term outcomes for patients with Cushing's disease (CD). The purpose of this study was to assess agreement by experts on recommended follow-up intervals for CD patients at different phases in their treatment course. METHODS: The RAND/UCLA modified Delphi process was used to assess expert consensus. Eleven clinicians who regularly manage CD patients rated 79 hypothetical patient scenarios before and after ("second round") an in-person panel discussion to clarify definitions...
March 9, 2017: Pituitary
https://www.readbyqxmd.com/read/28265842/jean-camus-and-gustave-roussy-pioneering-french-researchers-on-the-endocrine-functions-of-the-hypothalamus
#5
Inés Castro-Dufourny, Rodrigo Carrasco, Ruth Prieto, José M Pascual
At the beginning of the twentieth century, the hypothalamus was known merely as an anatomical region of the brain lying beneath the thalamus. An increasing number of clinicopathological reports had shown the association of diabetes insipidus and adiposogenital dystrophy (Babinski-Fröhlich's syndrome), with pituitary tumors involving the infundibulum and tuber cinereum, two structures of the basal hypothalamus. The French physicians Jean Camus (1872-1924) and Gustave Roussy (1874-1948) were the first authors to undertake systematic, controlled observations of the effects of localized injuries to the basal hypothalamus in dogs and cats by pricking the infundibulo-tuberal region (ITR) with a heated needle...
March 6, 2017: Pituitary
https://www.readbyqxmd.com/read/28265841/surgical-outcomes-in-patients-with-cushing-s-disease-the-cleveland-clinic-experience
#6
Philip C Johnston, Laurence Kennedy, Amir H Hamrahian, Zahrae Sandouk, James Bena, Betul Hatipoglu, Robert J Weil
CONTEXT: Transsphenoidal surgery (TSS) to resect a pituitary adenoma is considered first-line treatment for patients with Cushing's disease (CD). Early, post-operative remission rates >80% are expected for patients with a microadenoma (≤ 10 mm) visible on magnetic resonance (MR) imaging. OBJECTIVE: To report surgical outcomes and predictors of remission in a specialist center for patients with CD. PATIENTS AND METHODS: Clinical data was obtained from a prospective CD database in addition to review of all electronic medical, laboratory and surgical patient records...
March 6, 2017: Pituitary
https://www.readbyqxmd.com/read/28251542/sellar-and-clival-plasmacytomas-case-series-of-5-patients-with-systematic-review-of-65-published-cases
#7
REVIEW
Jane Lee, Edwin Kulubya, Barry D Pressman, Adam Mamelak, Serguei Bannykh, Gabriel Zada, Odelia Cooper
PURPOSE: Parasellar plasmacytomas are rare tumors localized to the sellar region arising from plasma cells. Knowledge of clinical, imaging, surgical, and pathological characteristics is limited to single case reports. METHODS: A retrospective analysis of five primary cases was conducted, followed by systematic review of English language articles using PubMed in accordance with PRISMA guidelines. RESULTS: Five primary case patients include four men and one woman, ages 60-77, followed up to 3 years...
March 1, 2017: Pituitary
https://www.readbyqxmd.com/read/28236168/david-l-kleinberg-in-memoriam-1937-2017
#8
(no author information available yet)
No abstract text is available yet for this article.
February 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28233140/clinical-characteristics-of-acromegalic-patients-with-empty-sella-and-their-outcomes-following-transsphenoidal-surgery
#9
Yasuo Sasagawa, Yasuhiko Hayashi, Osamu Tachibana, Masahiro Oishi, Issei Fukui, Hideaki Iizuka, Mitsutoshi Nakada
PURPOSE: To analyze the clinical characteristics of acromegalic patients with empty sella (ES, herniation of the subarachnoid space within the sella turcica) and the impact of ES on transsphenoidal surgery in such patients. METHODS: Seventy-eight patients, newly diagnosed with acromegaly who underwent transsphenoidal surgery were included. ES was defined as the pituitary gland and adenoma occupying less than 50% of the sella turcica on midsagittal magnetic resonance (MR) imaging...
February 23, 2017: Pituitary
https://www.readbyqxmd.com/read/28220351/two-dimensional-speckle-tracking-echocardiography-demonstrates-no-effect-of-active-acromegaly-on-left-ventricular-strain
#10
I C M Volschan, L Kasuki, C M S Silva, M L Alcantara, R M Saraiva, S S Xavier, M R Gadelha
BACKGROUND: Speckle tracking echocardiography (STE) allows for the study of myocardial strain (ε), a marker of early and subclinical ventricular systolic dysfunction. Cardiac disease may be present in patients with acromegaly; however, STE has never been used to evaluate these patients. OBJECTIVE: To evaluate left ventricular (LV) global longitudinal strain in patients with active acromegaly with normal LV systolic function. DESIGN: Cross-sectional clinical study...
February 20, 2017: Pituitary
https://www.readbyqxmd.com/read/28210909/the-longest-stalk-preserved-pituitary-function-after-regression-of-a-giant-prolactinoma
#11
LETTER
Jessica A Lundgren, Edward H Oldfield, John C Marshall
No abstract text is available yet for this article.
February 16, 2017: Pituitary
https://www.readbyqxmd.com/read/28210908/updates-in-outcomes-of-stereotactic-radiation-therapy-in-acromegaly
#12
REVIEW
Monica Livia Gheorghiu
Purpose Treatment of acromegaly has undergone important progress in the last 20 years mainly due to the development of new medical options and advances in surgical techniques. Pituitary surgery is usually first-line therapy, and medical treatment is indicated for persistent disease, while radiation (RT) is often used as third-line therapy. The benefits of RT (tumor volume control and decreased hormonal secretion) are hampered by the long latency of the effect and the high risk of adverse effects. Stereotactic RT methods have been developed with the aim to provide more precise targeting of the tumor with better control of the radiation dose received by the adjacent brain structures...
February 16, 2017: Pituitary
https://www.readbyqxmd.com/read/28197813/t2-weighted-mri-signal-intensity-as-a-predictor-of-hormonal-and-tumoral-responses-to-somatostatin-receptor-ligands-in-acromegaly-a-perspective
#13
REVIEW
Iulia Potorac, Albert Beckers, Jean-François Bonneville
T2-weighted MRI signal intensity of GH-secreting pituitary adenomas is gaining recognition as a marker of disease characteristics and may be a predictor of response to treatment of acromegaly. Adenomas that are T2-hypointense are more common, are smaller and are less likely to invade the cavernous sinus compared to the T2-iso and hyperintense tumors. T2-hypointense tumors are also accompanied by higher IGF1 values at baseline. When presurgical somatostatin receptor ligand (SRL) therapy is administered, T2-hypointense adenomas have better hormonal responses and have greater tumor shrinkage...
February 14, 2017: Pituitary
https://www.readbyqxmd.com/read/28154960/radiological-features-for-the-approach-in-trans-sphenoidal-pituitary-surgery
#14
Victoria Twigg, Simon D Carr, Ramkishan Balakumar, Saurabh Sinha, Showkat Mirza
INTRODUCTION: In order to perform trans-sphenoidal endoscopic pituitary surgery safely and efficiently it is important to identify anatomical and pituitary disease features on the pre-operative CT and MRI scans; thereby minimising the risk to surrounding structures and optimising outcomes. We aim to create a checklist to streamline pre-operative planning. METHODS: We retrospectively reviewed pre-operative CT and MRI scans of 100 adults undergoing trans-sphenoidal endoscopic pituitary surgery...
February 2, 2017: Pituitary
https://www.readbyqxmd.com/read/27873156/erratum-to-predictive-role-of-dynamic-contrast-enhanced-t1-weighted-mr-sequences-in-pre-surgical-evaluation-of-macroadenomas-consistency
#15
Andrea Romano, Valeria Coppola, Mariangela Lombardi, Luigi Lavorato, Domenica Di Stefano, Emanuela Caroli, Maria Camilla Rossi Espagnet, Francesca Tavanti, Giuseppe Minniti, Giuseppe Trillò, Alessandro Bozzao
No abstract text is available yet for this article.
April 2017: Pituitary
https://www.readbyqxmd.com/read/27812776/critical-review-of-igg4-related-hypophysitis
#16
Junpei Shikuma, Kenshi Kan, Rokuro Ito, Kazuo Hara, Hiroyuki Sakai, Takashi Miwa, Akira Kanazawa, Masato Odawara
PURPOSE: IgG4-related hypophysitis is a rare disease, with only 34 cases published in English (2015). Available short reviews may not present complete details of IgG4-related hypophysitis. We aimed to survey case reports of IgG4-related hypophysitis, including abstracts of scientific meetings, in English and Japanese. METHODS: We searched for information about IgG4-related hypophysitis in PubMed and Igakuchuozasshi (Japan Medical Abstracts Society). Among 104 case reports found, we reviewed 84 fulfilling Leporati's diagnostic criteria...
April 2017: Pituitary
https://www.readbyqxmd.com/read/27796709/effects-of-somatostatin-and-its-analogues-on-progenitor-mesenchymal-cells-isolated-from-human-pituitary-adenomas
#17
Monia Orciani, Miriam Caffarini, Giulia Sorgentoni, Riccardo Antonio Ricciuti, Giorgio Arnaldi, Roberto Di Primio
PURPOSE: Progenitor mesenchymal cells (PMCs) have been found also in epithelial tumors and may derive from cancer stem cells (CSCs) by EMT mechanism. In this scenario, the effects of traditionally drugs on PMCs become of primary concern for therapeutic approaches. Previously, we isolated PMCs from acromegalic (GHomas) and not-functioning pituitary adenomas (NFPAs). Here we evaluate: (1) the role of EMT on their origin; (2) the presence of the somatostatin receptors (SSTR1-5); (3) the effects of somatostatin (SST) and its analogues (SSAs) on PMCs proliferation, apoptosis and SSTR1-5 expression...
April 2017: Pituitary
https://www.readbyqxmd.com/read/27783196/management-of-prolactinomas-a-survey-of-physicians-from-the-middle-east-and-north-africa
#18
Salem A Beshyah, Ibrahim H Sherif, Farida Chentli, Amir Hamrahian, Aly B Khalil, Hussein Raef, Mohamed El-Fikki, Selim Jambart
BACKGROUND: Prolactinomas are the commonest functional tumors of the pituitary gland. There are still controversies regarding medical therapy in specific clinical situations. Patients may be managed by different specialists in the Middle East and North Africa (MENA) region and no data exist on patterns of clinical management. OBJECTIVES: To ascertain the diagnostic and therapeutic approaches to prolactinomas among relevant professionals from the MENA region. METHODS: An online survey of a large sample of physicians was conducted...
April 2017: Pituitary
https://www.readbyqxmd.com/read/27778295/lymphocytic-hypophysitis-modern-day-management-with-limited-role-for-surgery
#19
Angelos Kyriacou, Kanna Gnanalingham, Tara Kearney
PURPOSE: We set out to describe the modern day management of Lymphocytic hypophysitis (LH) with respect to its diagnosis, treatment and long-term endocrine and visual outcomes. We deliberately included patients with a clinical diagnosis of LH and compared them with those with a histological diagnosis following surgery. METHODS: A multi-centre observational study was performed. Twenty-two patients were included and studied over a mean follow-up period of 8.6 years (range 4-26 years)...
April 2017: Pituitary
https://www.readbyqxmd.com/read/27757801/significance-of-surgical-management-for-cystic-prolactinoma
#20
Toshihiro Ogiwara, Tetsuyoshi Horiuchi, Alhusain Nagm, Tetsuya Goto, Kazuhiro Hongo
PURPOSE: It is generally accepted that dopamine agonists (DA) represent the first-line treatment for most patients with prolactinoma, and patients become candidates for surgical intervention when DA is contraindicated. Surgical indication for cystic prolactinoma remains controversial. This study was performed to investigate the significance of surgery for cystic prolactinoma. METHODS: A total of 28 patients that underwent transsphenoidal resection of prolactinoma between February 2004 and May 2016 were reviewed...
April 2017: Pituitary
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