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Angiogenesis

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https://www.readbyqxmd.com/read/28795242/prox1-gfp-flt1-dsred-transgenic-mice-an-animal-model-for-simultaneous-live-imaging-of-angiogenesis-and-lymphangiogenesis
#1
Wei Zhong, Xinbo Gao, Shuangyong Wang, Kyuyeon Han, Masatsugu Ema, Susanne Adams, Ralf H Adams, Mark I Rosenblatt, Jin-Hong Chang, Dimitri T Azar
The roles of angiogenesis in development, health, and disease have been studied extensively; however, the studies related to lymphatic system are limited due to the difficulty in observing colorless lymphatic vessels. But recently, with the improved technique, the relative importance of the lymphatic system is just being revealed. We bred transgenic mice in which lymphatic endothelial cells express GFP (Prox1-GFP) with mice in which vascular endothelial cells express DsRed (Flt1-DsRed) to generate Prox1-GFP/Flt1-DsRed (PGFD) mice...
August 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28752390/pdgfr%C3%AE-p2a-creer-t2-mice-a-genetic-tool-to-target-pericytes-in-angiogenesis
#2
Henar Cuervo, Brianna Pereira, Taliha Nadeem, Mika Lin, Frances Lee, Jan Kitajewski, Chyuan-Sheng Lin
Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow for the targeting of pericytes in mouse models, limiting our ability to understand their biology. We have generated a novel mouse line expressing tamoxifen-inducible Cre-recombinase under the control of the platelet-derived growth factor receptor β promoter: PDGFRβ-P2A-CreER (T2) ...
July 27, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28741167/microvascular-ultrastructural-changes-precede-cognitive-impairment-in-the-murine-appswe-ps1de9-model-of-alzheimer-s-disease
#3
Patricia Kelly, Paul Denver, Simon C Satchell, Maximilian Ackermann, Moritz A Konerding, Christopher A Mitchell
Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer's disease (AD) neuropathology. In this study, we hypothesised that both cerebral and systemic microvascular pathologies exist in 4- to 5-month-old male APPswe/PS1dE9 (APP/PS1) transgenic mice prior to the onset of cognitive impairment. To assess this we examined recognition memory in both wild-type and APP/PS1 mice using the object recognition task (ORT; n = 11 per group) and counted thioflavin-S-positive plaques in brain (n = 6 per group)...
July 25, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28741166/a-new-key-player-in-vegf-dependent-angiogenesis-in-human-hepatocellular-carcinoma-dimethylarginine-dimethylaminohydrolase-1
#4
Nikki Buijs, J Efraim Oosterink, Morgan Jessup, Henk Schierbeek, Donna B Stolz, Alexander P Houdijk, David A Geller, Paul A van Leeuwen
BACKGROUND: Anti-angiogenic therapies, targeting VEGF, are a promising treatment for hepatocellular carcinoma (HCC). To enhance this potential therapy, identification of novel targets in this pathway is of major interest. Nitric oxide (NO) plays a crucial role in VEGF-dependent angiogenesis. NO production depends on arginine as substrate and asymmetric dimethylarginine (ADMA) as inhibitor. Dimethylarginine dimethylaminohydrolase 1 (DDAH-1) catabolizes ADMA and therefore regulates NO and VEGF expression...
July 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28741165/history-and-conceptual-developments-in-vascular-biology-and-angiogenesis-research-a-personal-view
#5
REVIEW
Andreas Bikfalvi
Vascular biology is an important scientific domain that has gradually penetrated many medical and scientific fields. Scientists are most often focused on present problems in their daily scientific work and lack awareness regarding the evolution of their domain throughout history and of how philosophical issues are related to their research field. In this article, I provide a personal view with an attempt to conceptualize vascular development research that articulates lessons taken from history, philosophy, biology and medicine...
July 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28725973/erratum-to-mirnas-micro-managers-of-anticancer-combination-therapies
#6
Judy R van Beijnum, Elisa Giovannetti, Dennis Poel, Patrycja Nowak-Sliwinska, Arjan W Griffioen
No abstract text is available yet for this article.
July 19, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28721500/early-prediction-of-tumor-response-to-bevacizumab-treatment-in-murine-colon-cancer-models-using-three-dimensional-dynamic-contrast-enhanced-ultrasound-imaging
#7
Jianhua Zhou, Huiping Zhang, Huaijun Wang, Amelie M Lutz, Ahmed El Kaffas, Lu Tian, Dimitre Hristov, Jürgen K Willmann
Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether three-dimensional (3D) dynamic contrast-enhanced ultrasound (DCE-US) imaging allows assessing early changes in tumor perfusion following antiangiogenic treatment (bevacizumab administered at a dose of 10 mg/kg b...
July 18, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28699046/optical-clearing-and-fluorescence-deep-tissue-imaging-for-3d-quantitative-analysis-of-the-brain-tumor-microenvironment
#8
Tonny Lagerweij, Sophie A Dusoswa, Adrian Negrean, Esther M L Hendrikx, Helga E de Vries, Jeroen Kole, Juan J Garcia-Vallejo, Huibert D Mansvelder, W Peter Vandertop, David P Noske, Bakhos A Tannous, René J P Musters, Yvette van Kooyk, Pieter Wesseling, Xi Wen Zhao, Thomas Wurdinger
BACKGROUND: Three-dimensional visualization of the brain vasculature and its interactions with surrounding cells may shed light on diseases where aberrant microvascular organization is involved, including glioblastoma (GBM). Intravital confocal imaging allows 3D visualization of microvascular structures and migration of cells in the brain of mice, however, with limited imaging depth. To enable comprehensive analysis of GBM and the brain microenvironment, in-depth 3D imaging methods are needed...
July 11, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28667352/endothelium-derived-fibronectin-regulates-neonatal-vascular-morphogenesis-in-an-autocrine-fashion
#9
Christopher J Turner, Kwabena Badu-Nkansah, Richard O Hynes
Fibronectin containing alternatively spliced EIIIA and EIIIB domains is largely absent from mature quiescent vessels in adults, but is highly expressed around blood vessels during developmental and pathological angiogenesis. The precise functions of fibronectin and its splice variants during developmental angiogenesis however remain unclear due to the presence of cardiac, somitic, mesodermal and neural defects in existing global fibronectin KO mouse models. Using a rare family of surviving EIIIA EIIIB double KO mice, as well as inducible endothelial-specific fibronectin-deficient mutant mice, we show that vascular development in the neonatal retina is regulated in an autocrine manner by endothelium-derived fibronectin, and requires both EIIIA and EIIIB domains and the RGD-binding α5 and αv integrins for its function...
June 30, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28660302/tumor-angiogenesis-and-vascular-normalization-alternative-therapeutic-targets
#10
REVIEW
Claire Viallard, Bruno Larrivée
Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal vascular network characterized by disorganized, immature and permeable blood vessels, resulting in poorly perfused tumors. The hypoxic microenvironment created by impaired tumor perfusion can promote the selection of more invasive and aggressive tumor cells and can also impede the tumor-killing action of immune cells. Furthermore, abnormal tumor perfusion also reduces the diffusion of chemotherapeutic drugs and radiotherapy efficiency...
June 28, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28638990/pharmacological-intervention-of-mkl-srf-signaling-by-ccg-1423-impedes-endothelial-cell-migration-and-angiogenesis
#11
David Gau, William Veon, Teresa L Capasso, Ralph Bottcher, Sanjeev Shroff, Beth L Roman, Partha Roy
De novo synthesis of cytoskeleton-regulatory proteins triggered by the megakaryoblastic leukemia (MKL)/serum response factor (SRF) transcriptional system in response to pro-angiogenic growth factors lies at the heart of endothelial cell (EC) migration (a critical element of angiogenesis) and neovascularization. This study explores whether pharmacological intervention of MKL/SRF signaling axis by CCG-1423 is able to suppress angiogenesis. Our studies show that CCG-1423 inhibits migration and cord morphogenesis of EC in vitro and sprouting angiogenesis ex vivo and in vivo, suggesting CCG-1423 could be a novel anti-angiogenic agent...
June 21, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28623423/cxcl10-suppression-of-hem-and-lymph-angiogenesis-in-inflamed-corneas-through-mmp13
#12
Nan Gao, Xiaowei Liu, Jiayin Wu, Juan Li, Chen Dong, Xinyi Wu, Xiao Xiao, Fu-Shin X Yu
Though not present in the normal adult cornea, both hem- and lymph-angiogenesis can be induced in this tissue after an inflammatory, infectious, or traumatic insult. We previously showed that the chemokine CXCL10 plays a key role in eradicating invading Candida (C.) albicans in C57BL6 mouse corneas. However, even after the clearance of pathogens, infection-induced inflammation and angiogenesis continue to progress in the cornea. The aim of this study is define the role of CXCL10 as a major angiostatic factor in modulating cornea angiogenesis in B6 mouse corneas under pathogenic conditions...
June 16, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28608153/low-levels-of-physiological-interstitial-flow-eliminate-morphogen-gradients-and-guide-angiogenesis
#13
Venktesh S Shirure, Andrew Lezia, Arnold Tao, Luis F Alonzo, Steven C George
Convective transport can significantly distort spatial concentration gradients. Interstitial flow is ubiquitous throughout living tissue, but our understanding of how interstitial flow affects concentration gradients in biological processes is limited. Interstitial flow is of particular interest for angiogenesis because pathological and physiological angiogenesis is associated with altered interstitial flow, and both interstitial flow and morphogen gradients (e.g., vascular endothelial growth factor, VEGF) can potentially stimulate and guide new blood vessel growth...
June 12, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28421290/pulsatile-high-dose-treatment-with-antiangiogenic-tyrosine-kinase-inhibitors-improves-clinical-antitumor-activity
#14
LETTER
Maria Rovithi, Henk M W Verheul
No abstract text is available yet for this article.
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28397127/a-novel-strategy-to-enhance-angiogenesis-in-vivo-using-the-small-vegf-binding-peptide-pr1p
#15
Avner Adini, Irit Adini, Zai-Long Chi, Ratmir Derda, Amy E Birsner, Benjamin D Matthews, Robert J D'Amato
Therapeutic angiogenesis is an experimental frontier in vascular biology that seeks to deliver angiogenic growth factors to ischemic or injured tissues to promote targeted formation of new blood vessels as an alternative approach to surgical revascularization procedures. Vascular endothelial growth factor (VEGF) is a potent angiogenic signal protein that is locally upregulated at sites of tissue injury. However, therapies aimed at increasing VEGF levels experimentally by injecting VEGF gene or protein failed to improve outcomes in human trials in part due to its short half-life and systemic toxicity...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28391377/pro-angiogenic-capacities-of-microvesicles-produced-by-skin-wound-myofibroblasts
#16
Mays Merjaneh, Amélie Langlois, Sébastien Larochelle, Chanel Beaudoin Cloutier, Sylvie Ricard-Blum, Véronique J Moulin
Wound healing is a very highly organized process where numerous cell types are tightly regulated to restore injured tissue. Myofibroblasts are cells that produce new extracellular matrix and contract wound edges. We previously reported that the human myofibroblasts isolated from normal wound (WMyos) produced microvesicles (MVs) in the presence of the serum. In this study, MVs were further characterized using a proteomic strategy and potential functions of the MVs were determined. MV proteins isolated from six WMyo populations were separated using two-dimensional differential gel electrophoresis...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28374123/blood-flow-can-signal-during-angiogenesis-not-only-through-mechanotransduction-but-also-by-affecting-growth-factor-distribution
#17
Siavash Ghaffari, Richard L Leask, Elizabeth A V Jones
Growth factors, such as VEGF, promote the sprouting of new blood vessels. Growth factors are generally produced far from the endothelium, and the transport of these proteins is often assumed to occur through diffusion. When sprouting occurs in a perfused vascular bed, however, interstitial flow is present that can modify protein transport. We recently developed a technique to analyze flow dynamics and vascular remodeling simultaneously in avian embryos. In this study, we extend our technique to model interstitial flow through the porous matrix of the mesenchymal tissue and use this to investigate how flow in the blood vessels affects the distribution of growth factors in the mesenchyme, using VEGF as a prototypical angiogenic molecule...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28283856/effects-of-nintedanib-on-the-microvascular-architecture-in-a-lung-fibrosis-model
#18
Maximilian Ackermann, Yong Ook Kim, Willi L Wagner, Detlef Schuppan, Cristian D Valenzuela, Steven J Mentzer, Sebastian Kreuz, Detlef Stiller, Lutz Wollin, Moritz A Konerding
Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the impact of nintedanib on microvascular architecture in a pulmonary fibrosis model. Lung fibrosis was induced in C57Bl/6 mice by intratracheal bleomycin (0.5 mg/kg). Nintedanib was started after the onset of lung pathology (50 mg/kg twice daily, orally). Micro-computed tomography was performed via volumetric assessment. Static lung compliance and forced vital capacity were determined by invasive measurements...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28271280/rcan1-4-regulates-vegfr-2-internalisation-cell-polarity-and-migration-in-human-microvascular-endothelial-cells
#19
Ahmad F Alghanem, Emma L Wilkinson, Maxine S Emmett, Mohammad A Aljasir, Katherine Holmes, Beverley A Rothermel, Victoria A Simms, Victoria L Heath, Michael J Cross
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is highly upregulated in response to VEGF in human endothelial cells in contrast to RCAN1.1 and is essential for efficient endothelial cell migration and tubular morphogenesis. Here, we show that RCAN1...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28197812/mcpip1-contributes-to-clear-cell-renal-cell-carcinomas-development
#20
Janusz Ligeza, Paulina Marona, Natalia Gach, Barbara Lipert, Katarzyna Miekus, Waclaw Wilk, Janusz Jaszczynski, Andrzej Stelmach, Agnieszka Loboda, Jozef Dulak, Wojciech Branicki, Janusz Rys, Jolanta Jura
Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1, is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the stability of transcripts coding for proinflammatory cytokines and controlling activity of transcription factors, such as NF-κB and AP1. We found that MCPIP1 transcript and protein levels are strongly downregulated in clear cell renal cell carcinoma (ccRCC) samples, which were derived from patients surgically treated for renal cancer compared to surrounded normal tissues...
August 2017: Angiogenesis
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