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Angiogenesis

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https://www.readbyqxmd.com/read/28108843/ets-transcription-factors-etv2-and-fli1b-are-required-for-tumor-angiogenesis
#1
Kristina Baltrunaite, Michael P Craig, Sharina Palencia Desai, Praneet Chaturvedi, Ram Naresh Pandey, Rashmi S Hegde, Saulius Sumanas
ETS transcription factor ETV2/Etsrp functions as a key regulator of embryonic vascular development in multiple vertebrates. However, its role in pathological vascular development has not been previously investigated. To analyze its role in tumor angiogenesis, we utilized a zebrafish xenotransplantation model. Using a photoconvertible kdrl:NLS-KikGR line, we demonstrated that all tumor vessels originate from the existing embryonic vasculature by the mechanism of angiogenesis. Xenotransplantation of mouse B16 melanoma cells resulted in a significant increase in expression of the ETS transcription factors etv2 and fli1b expression throughout the embryonic vasculature...
January 20, 2017: Angiogenesis
https://www.readbyqxmd.com/read/27990590/angiopoietins-as-serum-biomarkers-for-lymphatic-anomalies
#2
Timothy D Le Cras, Paula S Mobberley-Schuman, Mary Broering, Lin Fei, Cameron C Trenor, Denise M Adams
Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid diagnosis and potentially give insights into pathogenesis. Blood was collected at baseline and then 6 and 12 months after treatment with the mTOR inhibitor sirolimus. Patients groups included generalized lymphatic anomaly (GLA), kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE) with or without the Kasabach-Merritt phenomenon (KMP) coagulopathy...
December 18, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27942994/a-new-algorithm-for-a-better-characterization-and-timing-of-the-anti-vegf-vascular-effect-named-normalization
#3
Karima El Alaoui-Lasmaili, El-Hadi Djermoune, Jean-Baptiste Tylcz, Dominique Meng, François Plénat, Noémie Thomas, Béatrice Faivre
Antiangiogenics are widely used in cancer treatment in combination with chemotherapy and radiotherapy for their vascular effects. Antiangiogenics are supposed to induce morphological and functional changes in the chaotic tumor vasculature that would help enhance the therapeutic efficacy of chemotherapy and radiotherapy through the amelioration of the drug delivery or the oxygenation in the tumor, respectively. However, finding the best treatment sequence is not an easy task to achieve and no consensus has yet been established because of the lack of knowledge regarding when and for how long the vascular network is ameliorated...
December 10, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27943030/the-role-of-endoglin-in-post-ischemic-revascularization
#4
REVIEW
Elena Núñez-Gómez, Miguel Pericacho, Claudia Ollauri-Ibáñez, Carmelo Bernabéu, José M López-Novoa
Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into physiologically relevant arteries (collateral development). All these processes result in the recovery of organ perfusion. The importance of endoglin in post-occlusion reperfusion is sustained by several observations: (1) endoglin expression is increased in vessels showing active angiogenesis/remodeling; (2) genetic endoglin haploinsufficiency in humans causes deficient angiogenesis; and (3) the reduction of endoglin expression by gene disruption or the administration of endoglin-neutralizing antibodies reduces angiogenesis and revascularization...
December 9, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27921229/an-extracellular-proteasome-releases-endostatin-from-human-collagen-xviii
#5
Maria L V Reiss-Pistilli, Detlef Schuppan, Madalena M S Barroso, Iranaia Assunção-Miranda, Shirley Farias, Letícia Lery, Michael Bauer, Luiz Juliano, Maria A Juliano, Tatiana Coelho-Sampaio
Endostatin is a potent anti-angiogenic and anti-tumor protein capable of regressing tumors without inducing acquired resistance. Since it is a fragment of the parental molecule, collagen XVIII, its endogenous production depends on the activity of a specific proteolytic enzyme. While such an enzyme has been described in mice, a human counterpart has not been identified so far. Here, we searched for this enzyme by using a fluorescence resonance energy transfer peptide containing the cleavage site of human collagen XVIII...
December 5, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27896475/an-exploratory-association-of-polymorphisms-in-angiogenesis-related-genes-with-susceptibility-clinical-response-and-toxicity-in-gastrointestinal-stromal-tumors-receiving-sunitinib-after-imatinib-failure
#6
Gloria Ravegnini, Margherita Nannini, Corrado Zenesini, Vittorio Simeon, Giulia Sammarini, Milena Urbini, Lidia Gatto, Maristella Saponara, Guido Biasco, Maria A Pantaleo, Nicola Venturoli, Patrizia Hrelia, Sabrina Angelini
The angiogenic pathway plays a pivotal role in tumor growth, invasiveness and metastasis. The most important actors in the angiogenic pathway are VEGFA and its receptors VEGFR1, 2 and 3. These genes are polymorphic, and the presence of single nucleotide polymorphisms may result in angiogenic deregulation. Herein, we hypothesized that germline variants may affect sunitinib efficacy (TTP and OS) and/or toxicity. Therefore, we investigated 19 polymorphisms, in four genes, in 54 GIST patients, treated with second-line sunitinib and 147 healthy controls...
November 28, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27873103/differential-regulation-of-angiogenic-cellular-processes-and-claudin-5-by-histamine-and-vegf-via-pi3k-signaling-transcription-factor-snai2-and-interleukin-8
#7
Johanna P Laakkonen, Jari P Lappalainen, Thomas L Theelen, Pyry I Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U Kaikkonen, Judith C Sluimer, Seppo Ylä-Herttuala
AIMS: Histamine and vascular endothelial growth factor A (VEGF) are central regulators in vascular pathologies. Their gene regulation leading to vascular remodeling has remained obscure. In this study, EC regulation mechanisms of histamine and VEGF were compared by RNA sequencing of primary endothelial cells (ECs), functional in vitro assays and in vivo permeability mice model. METHODS AND RESULTS: By RNA sequencing, similar transcriptional alterations of genes involved in activation of primary ECs, cell proliferation and adhesion were observed between histamine and VEGF...
November 21, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27853962/enhanced-peripheral-dopamine-impairs-post-ischemic-healing-by-suppressing-angiotensin-receptor-type-1-expression-in-endothelial-cells-and-inhibiting-angiogenesis
#8
Chandrani Sarkar, Ramesh K Ganju, Vincent J Pompili, Debanjan Chakroborty
Increased circulating catecholamines have been linked with cardiovascular anomalies as well as with peripheral vascular diseases. Although the roles of epinephrine and norepinephrine have received considerable attention, the role of the other catecholamine, dopamine, has been less studied. Since dopamine is a potent endogenous inhibitor of angiogenesis and as angiogenesis is essential for ischemic healing, we therefore studied the role played by dopamine during ischemic healing using dopamine D2 receptor knockout (KOD2) mice...
November 16, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27807692/tissue-factor-is-an-angiogenic-specific-receptor-for-factor-vii-targeted-immunotherapy-and-photodynamic-therapy
#9
Zhiwei Hu, Jijun Cheng, Jie Xu, Wolfram Ruf, Charles J Lockwood
Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls...
November 2, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27787629/lymphangiogenesis-in-rat-asthma-model
#10
Aigul Moldobaeva, John Jenkins, Qiong Zhong, Elizabeth M Wagner
Although bronchial angiogenesis has been well documented in allergic asthma, lymphangiogenesis has not been widely studied. Therefore, we evaluated changes in lung lymphatics in a rat model of allergen-induced asthma using house dust mite (Der p 1; 100 μg/challenge). Additionally, properties of isolated lung lymphatic endothelial cells (CD45(-), CD141(+), LYVE-1(+), Prox-1(+)) were studied in vitro. Three weeks after the onset of intranasal allergen exposure (twice-weekly), an increase in the number of lung lymphatic vessels was measured (34% increase) by lung morphometry...
October 27, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27743086/bp-1t-an-antiangiogenic-benzophenone-thiazole-pharmacophore-counteracts-hif-1-signalling-through-p53-mdm2-mediated-hif-1%C3%AE-proteasomal-degradation
#11
Prabhu Thirusangu, V Vigneshwaran, T Prashanth, B R Vijay Avin, Vikas H Malojirao, H Rakesh, Shaukath Ara Khanum, Riaz Mahmood, B T Prabhakar
Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its expression is positively correlated with poor prognosis for cancer patients, HIF-1α is one of the most convincing anticancer targets. BP-1T is a novel antiproliferative agent with promising antiangiogenic effects. In the present study, the molecular mechanism underlying cytotoxic/antiangiogenic effects of BP-1T on tumour/non-tumour angiogenesis was evaluated...
October 14, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27699500/identification-of-hif-2%C3%AE-regulated-genes-that-play-a-role-in-human-microvascular-endothelial-sprouting-during-prolonged-hypoxia-in-vitro
#12
Tessa D Nauta, Marloes van den Broek, Sue Gibbs, Tineke C T M van der Pouw-Kraan, Cees B Oudejans, Victor W M van Hinsbergh, Pieter Koolwijk
During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α partially restores sprout formation. The present study identifies novel HIF-2α-target genes that may regulate endothelial sprouting during prolonged hypoxia. The gene expression profile of primary human microvascular endothelial cells (hMVECs) that were cultured at 20 % oxygen was compared to hMVECs that were cultured at 1 % oxygen for 14 days by using genome-wide RNA-sequencing...
October 3, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27695972/aliskiren-decreases-oxidative-stress-and-angiogenic-markers-in-retinal-pigment-epithelium-cells
#13
Sónia Simão, Daniela F Santos, Gabriela A Silva
There is growing evidence on the role of ocular renin-angiotensin system (RAS) in the development of diabetic retinopathy (DR), particularly due to the trigger of oxidative stress and angiogenesis. Despite this there is no effective RAS-based therapy in DR capable of preventing retinal damage induced by RAS activation. We recently described that retinal pigment epithelium (RPE) cells express the main components of the RAS. We here propose to investigate the role of glucose upon the retinal RAS and whether aliskiren, a direct renin inhibitor, protects RPE cells from angiogenesis and oxidative stress...
October 1, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27582011/contrast-enhanced-ct-imaging-in-patients-with-chronic-kidney-disease
#14
Saskia von Stillfried, Jonas C Apitzsch, Josef Ehling, Tobias Penzkofer, Andreas H Mahnken, Ruth Knüchel, Jürgen Floege, Peter Boor
Renal microvascular rarefaction characterizes chronic kidney disease (CKD). In murine models of CKD, micro-CT imaging reflected capillary rarefaction using quantification of renal relative blood volume (rBV). In addition, micro-CT imaging revealed morphological alterations of the intrarenal vasculature including reduced vascular branching and lumen diameter. Here, we retrospectively quantified rBV in contrast-enhanced CT angiography in patients and found that, compared to non-CKD patients, those with CKD and renal fibrosis had significantly reduced rBV in the renal cortex...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27464987/regulation-of-lymphangiogenesis-in-the-diaphragm-by-macrophages-and-vegfr-3-signaling
#15
Alexandra M Ochsenbein, Sinem Karaman, Steven T Proulx, Rhea Goldmann, Jyothi Chittazhathu, Athanasia Dasargyri, Chloé Chong, Jean-Christophe Leroux, E Richard Stanley, Michael Detmar
Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earliest lymphatic vessel differentiation and development has been investigated in much detail, less is known about the control and timing of lymphatic vessel maturation in different organs, which often occurs postnatally. We investigated the time course of lymphatic vessel development on the pleural side of the diaphragmatic muscle in mice, the so-called submesothelial initial diaphragmatic lymphatic plexus...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27387982/prostate-specific-membrane-antigen-psma-mediated-laminin-proteolysis-generates-a-pro-angiogenic-peptide
#16
Rebecca E Conway, Camilo Rojas, Jesse Alt, Zora Nováková, Spencer M Richardson, Tori C Rodrick, Julio L Fuentes, Noah H Richardson, Jonathan Attalla, Samantha Stewart, Beshoy Fahmy, Cyril Barinka, Mallika Ghosh, Linda H Shapiro, Barbara S Slusher
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase expressed in a number of tissues. PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate. PSMA expression is also progressively upregulated in prostate cancer where it correlates with tumor progression as well as in tumor vasculature, where it regulates angiogenesis...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27380212/celecoxib-and-octreotide-synergistically-ameliorate-portal-hypertension-via-inhibition-of-angiogenesis-in-cirrhotic-rats
#17
Jin-Hang Gao, Shi-Lei Wen, Shi Feng, Wen-Juan Yang, Yao-Yao Lu, Huan Tong, Rui Liu, Shi-Hang Tang, Zhi-Yin Huang, Ying-Mei Tang, Jin-Hui Yang, Hui-Qi Xie, Cheng-Wei Tang
Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological treatment, no efficient medication or regime has been explored to treat the early stage of cirrhosis when angiogenesis is initiated or overwhelming. In this study, we explored an anti-angiogenesis effort through non-cytotoxic drugs octreotide and celecoxib to treat early stage of cirrhotic portal hypertension in an animal model. Peritoneal injection of thioacetamide (TAA) was employed to induce liver cirrhosis in rats...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27338829/a-non-canonical-role-for-desmoglein-2-in-endothelial-cells-implications-for-neoangiogenesis
#18
Lisa M Ebert, Lih Y Tan, M Zahied Johan, Kay Khine Myo Min, Michaelia P Cockshell, Kate A Parham, Kelly L Betterman, Paceman Szeto, Samantha Boyle, Lokugan Silva, Angela Peng, YouFang Zhang, Andrew Ruszkiewicz, Andrew C W Zannettino, Stan Gronthos, Simon Koblar, Natasha L Harvey, Angel F Lopez, Mark Shackleton, Claudine S Bonder
Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the junctional stability to tolerate mechanical stress. However, one member of this family, DSG2, is emerging as a protein with additional biological functions on a broader range of cells. Here we reveal that DSG2 is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts [endothelial cells (ECs)] in human tissue from healthy individuals and cancer patients...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27325285/persistent-infiltration-and-pro-inflammatory-differentiation-of-monocytes-cause-unresolved-inflammation-in-brain-arteriovenous-malformation
#19
Rui Zhang, Zhenying Han, Vincent Degos, Fanxia Shen, Eun-Jung Choi, Zhengda Sun, Shuai Kang, Michael Wong, Wan Zhu, Lei Zhan, Helen M Arthur, S Paul Oh, Marie E Faughnan, Hua Su
An abnormally high number of macrophages are present in human brain arteriovenous malformations (bAVM) with or without evidence of prior hemorrhage, causing unresolved inflammation that may enhance abnormal vascular remodeling and exacerbate the bAVM phenotype. The reasons for macrophage accumulation at the bAVM sites are not known. We tested the hypothesis that persistent infiltration and pro-inflammatory differentiation of monocytes in angiogenic tissues increase the macrophage burden in bAVM using two mouse models and human monocytes...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27679502/androgens-modulate-male-derived-endothelial-cell-homeostasis-using-androgen-receptor-dependent-and-receptor-independent-mechanisms
#20
Verónica Torres-Estay, Daniela V Carreño, Patricia Fuenzalida, Anica Watts, Ignacio F San Francisco, Viviana P Montecinos, Paula C Sotomayor, John Ebos, Gary J Smith, Alejandro S Godoy
BACKGROUND: Sex-related differences in the role of androgen have been reported in cardiovascular diseases and angiogenesis. Moreover, androgen receptor (AR) has been causally involved in the homeostasis of human prostate endothelial cells. However, levels of expression, functionality and biological role of AR in male- and female-derived human endothelial cells (ECs) remain poorly characterized. The objectives of this work were (1) to characterize the functional expression of AR in male- and female-derived human umbilical vein endothelial cell (HUVEC), and (2) to specifically analyze the biological effects of DHT, and the role of AR on these effects, in male-derived HUVECs (mHUVECs)...
September 27, 2016: Angiogenesis
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