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Angiogenesis

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https://www.readbyqxmd.com/read/29030736/n-tert-butyloxycarbonyl-phe-leu-phe-leu-phe-boc2-inhibits-the-angiogenic-activity-of-heparin-binding-growth-factors
#1
Imtiaz M Nawaz, Paola Chiodelli, Sara Rezzola, Giuseppe Paganini, Michela Corsini, Alessio Lodola, Alessio Di Ianni, Marco Mor, Marco Presta
The peptides N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) and BOC-Met-Leu-Phe (BOC1) are widely used antagonists of formyl peptide receptors (FPRs), BOC2 acting as an FPR1/FPR2 antagonist whereas BOC1 inhibits FPR1 only. Extensive investigations have been performed by using these FPR antagonists as a tool to assess the role of FPRs in physiological and pathological conditions. Based on previous observations from our laboratory, we assessed the possibility that BOC2 may exert also a direct inhibitory effect on the angiogenic activity of vascular endothelial growth factor-A (VEGF-A)...
October 13, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28993956/notch-signaling-controls-sprouting-angiogenesis-of-endometriotic-lesions
#2
Christina Körbel, Miriam D Gerstner, Michael D Menger, Matthias W Laschke
Angiogenesis is essential for the engraftment and growth of endometriotic lesions. In this study, we analyzed whether this process is regulated by Notch signaling. Endometriotic lesions were induced by endometrial tissue transplantation into dorsal skinfold chambers of C57BL/6 mice, which were treated with the γ-secretase inhibitor DAPT or vehicle. Vascularization, morphology, and proliferation of the newly developing lesions were analyzed using intravital fluorescence microscopy, histology, and immunohistochemistry over 14 days...
October 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28993906/antiangiogenesis-and-medical-therapy-failure-in-intracranial-atherosclerosis
#3
Nestor R Gonzalez, Raymond Liou, Florian Kurth, Hao Jiang, Jeffrey Saver
Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide and the one with the worst prognosis. In this study, we assessed the hypothesis that the balance of circulating pro- and antiangiogenic factors plays a role in the evolution of the disease and can be used as a potential marker for the disease course and a target for treatment. Seventy-four patients with severe ICAD were enrolled in this prospective observational study, medically optimized, and followed for 6 months...
October 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28988272/pre-culture-in-endothelial-growth-medium-enhances-the-angiogenic-properties-of-adipose-derived-stem-stromal-cells
#4
Lucas E B Souza, Liziane R Beckenkamp, Lays M Sobral, Daianne M C Fantacini, Fernanda U F Melo, Josiane S Borges, Andréia M Leopoldino, Simone Kashima, Dimas Tadeu Covas
Considerable progress has been made on the development of adipose-derived stem/stromal cells (ASCs) as pro-angiogenic therapeutic tools. However, variable clinical results highlight the need for devising strategies to enhance their therapeutic efficacy. Since ASCs proliferate and stabilize newly formed vessels during the angiogenic phase of adipose tissue formation, we hypothesized that mimicking an angiogenic milieu during culture of ASCs would enhance their capacity to support endothelial cell survival and angiogenesis...
October 7, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28956197/bone-marrow-sinusoidal-endothelium-damage-and-potential-regeneration-following-cancer-radiotherapy-or-chemotherapy
#5
REVIEW
Mohammadhossein Hassanshahi, Alireza Hassanshahi, Samira Khabbazi, Yu-Wen Su, Cory J Xian
It is very well known that bone marrow (BM) microvasculature may possess a crucial role in the maintenance of homeostasis of BM due to mutual interactions between BM microvascular system and other physiological functions including haematopoiesis and osteogenesis. Chemotherapy and radiotherapy are known as main approaches for cancer treatment and also are known as the main cause of damage to the BM microvascular system. However, despite the importance of BM microvasculature in orchestrating various biological functions, less attention has been drawn to address the underlying mechanisms for the damage and to explore cellular and molecular mechanisms by which the recovery/regeneration of chemotherapy- and/or radiotherapy-induced BM microvascular system damage can occur...
September 27, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28951988/a-genomic-screen-for-angiosuppressor-genes-in-the-tumor-endothelium-identifies-a-multifaceted-angiostatic-role-for-bromodomain-containing-7-brd7
#6
Judy R van Beijnum, Patrycja Nowak-Sliwinska, Maaike van Berkel, Tse J Wong, Arjan W Griffioen
Tumor angiogenesis is characterized by deregulated gene expression in endothelial cells (EC). While studies until now have mainly focused on overexpressed genes in tumor endothelium, we here describe the identification of transcripts that are repressed in tumor endothelium and thus have potential suppressive effects on angiogenesis. We identified nineteen putative angiosuppressor genes, one of them being bromodomain containing 7 (BRD7), a gene that has been assigned tumor suppressor properties. BRD7 was studied in more detail, and we demonstrate that BRD7 expression is inversely related to EC activation...
September 26, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28905243/3d-endothelial-cell-spheroid-human-vitreous-humor-assay-for-the-characterization-of-anti-angiogenic-inhibitors-for-the-treatment-of-proliferative-diabetic-retinopathy
#7
Sara Rezzola, Imtiaz M Nawaz, Anna Cancarini, Cosetta Ravelli, Stefano Calza, Francesco Semeraro, Marco Presta
Proliferative diabetic retinopathy (PDR) represents a main cause of acquired blindness. Despite the recognition of the key role exerted by vascular endothelial growth factor (VEGF) in the pathogenesis of PDR, limitations to anti-VEGF therapies do exist. Thus, rapid and cost-effective angiogenesis assays are crucial for the screening of anti-angiogenic drug candidates for PDR therapy. In this context, evaluation of the angiogenic potential of PDR vitreous fluid may represent a valuable tool for preclinical assessment of angiostatic molecules...
September 13, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28875379/tumor-vessel-disintegration-by-maximum-tolerable-pfkfb3-blockade
#8
Lena-Christin Conradi, Aleksandra Brajic, Anna Rita Cantelmo, Ann Bouché, Joanna Kalucka, Andreas Pircher, Ulrike Brüning, Laure-Anne Teuwen, Stefan Vinckier, Bart Ghesquière, Mieke Dewerchin, Peter Carmeliet
Blockade of the glycolytic activator PFKFB3 in cancer cells (using a maximum tolerable dose of 70 mg/kg of the PFKFB3 blocker 3PO) inhibits tumor growth in preclinical models and is currently being tested as a novel anticancer treatment in phase I clinical trials. However, a detailed preclinical analysis of the effects of such maximum tolerable dose of a PFKFB3 blocker on the tumor vasculature is lacking, even though tumor endothelial cells are hyper-glycolytic. We report here that a high dose of 3PO (70 mg/kg), which inhibits cancer cell proliferation and reduces primary tumor growth, causes tumor vessel disintegration, suppresses endothelial cell growth for protracted periods, (model-dependently) aggravates tumor hypoxia, and compromises vascular barrier integrity, thereby rendering tumor vessels more leaky and facilitating cancer cell intravasation and dissemination...
September 5, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28840415/endothelial-progenitor-cells-in-multiple-myeloma-neovascularization-a-brick-to-the-wall
#9
REVIEW
Maria Margarida Tenreiro, Maria Leonor Correia, Maria Alexandra Brito
Multiple myeloma (MM) is characterized by the clonal expansion of plasma cells in the bone marrow that leads to events such as bone destruction, anaemia and renal failure. Despite the several therapeutic options available, there is still no effective cure, and the standard survival is up to 4 years. The evolution from the asymptomatic stage of monoclonal gammopathy of undetermined significance to MM and the progression of the disease itself are related to cellular and molecular alterations in the bone marrow microenvironment, including the development of the vasculature...
August 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28840375/frizzled-5-a-high-affinity-receptor-for-secreted-frizzled-related-protein-2-activation-of-nuclear-factor-of-activated-t-cells-c3-signaling-to-promote-angiogenesis
#10
Yuri K Peterson, Patrick Nasarre, Ingrid V Bonilla, Eleanor Hilliard, Jennifer Samples, Thomas A Morinelli, Elizabeth G Hill, Nancy Klauber-DeMore
Secreted frizzled-related protein 2 (SFRP2) is a pro-angiogenic factor expressed in the vasculature of a wide variety of human tumors, and modulates angiogenesis via the calcineurin-dependent nuclear factor of activated T-cells cytoplasmic 3 (NFATc3) pathway in endothelial cells. However, until now, SFRP2 receptor for this pathway was unknown. In the present study, we first used amino acid alignments and molecular modeling to demonstrate that SFRP2 interaction with frizzled-5 (FZD5) is typical of Wnt/FZD family members...
August 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28795242/prox1-gfp-flt1-dsred-transgenic-mice-an-animal-model-for-simultaneous-live-imaging-of-angiogenesis-and-lymphangiogenesis
#11
Wei Zhong, Xinbo Gao, Shuangyong Wang, Kyuyeon Han, Masatsugu Ema, Susanne Adams, Ralf H Adams, Mark I Rosenblatt, Jin-Hong Chang, Dimitri T Azar
The roles of angiogenesis in development, health, and disease have been studied extensively; however, the studies related to lymphatic system are limited due to the difficulty in observing colorless lymphatic vessels. But recently, with the improved technique, the relative importance of the lymphatic system is just being revealed. We bred transgenic mice in which lymphatic endothelial cells express GFP (Prox1-GFP) with mice in which vascular endothelial cells express DsRed (Flt1-DsRed) to generate Prox1-GFP/Flt1-DsRed (PGFD) mice...
August 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28752390/pdgfr%C3%AE-p2a-creer-t2-mice-a-genetic-tool-to-target-pericytes-in-angiogenesis
#12
Henar Cuervo, Brianna Pereira, Taliha Nadeem, Mika Lin, Frances Lee, Jan Kitajewski, Chyuan-Sheng Lin
Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow for the targeting of pericytes in mouse models, limiting our ability to understand their biology. We have generated a novel mouse line expressing tamoxifen-inducible Cre-recombinase under the control of the platelet-derived growth factor receptor β promoter: PDGFRβ-P2A-CreER (T2) ...
July 27, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28741167/microvascular-ultrastructural-changes-precede-cognitive-impairment-in-the-murine-appswe-ps1de9-model-of-alzheimer-s-disease
#13
Patricia Kelly, Paul Denver, Simon C Satchell, Maximilian Ackermann, Moritz A Konerding, Christopher A Mitchell
Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer's disease (AD) neuropathology. In this study, we hypothesised that both cerebral and systemic microvascular pathologies exist in 4- to 5-month-old male APPswe/PS1dE9 (APP/PS1) transgenic mice prior to the onset of cognitive impairment. To assess this we examined recognition memory in both wild-type and APP/PS1 mice using the object recognition task (ORT; n = 11 per group) and counted thioflavin-S-positive plaques in brain (n = 6 per group)...
July 25, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28421290/pulsatile-high-dose-treatment-with-antiangiogenic-tyrosine-kinase-inhibitors-improves-clinical-antitumor-activity
#14
LETTER
Maria Rovithi, Henk M W Verheul
No abstract text is available yet for this article.
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28397127/a-novel-strategy-to-enhance-angiogenesis-in-vivo-using-the-small-vegf-binding-peptide-pr1p
#15
Avner Adini, Irit Adini, Zai-Long Chi, Ratmir Derda, Amy E Birsner, Benjamin D Matthews, Robert J D'Amato
Therapeutic angiogenesis is an experimental frontier in vascular biology that seeks to deliver angiogenic growth factors to ischemic or injured tissues to promote targeted formation of new blood vessels as an alternative approach to surgical revascularization procedures. Vascular endothelial growth factor (VEGF) is a potent angiogenic signal protein that is locally upregulated at sites of tissue injury. However, therapies aimed at increasing VEGF levels experimentally by injecting VEGF gene or protein failed to improve outcomes in human trials in part due to its short half-life and systemic toxicity...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28391377/pro-angiogenic-capacities-of-microvesicles-produced-by-skin-wound-myofibroblasts
#16
Mays Merjaneh, Amélie Langlois, Sébastien Larochelle, Chanel Beaudoin Cloutier, Sylvie Ricard-Blum, Véronique J Moulin
Wound healing is a very highly organized process where numerous cell types are tightly regulated to restore injured tissue. Myofibroblasts are cells that produce new extracellular matrix and contract wound edges. We previously reported that the human myofibroblasts isolated from normal wound (WMyos) produced microvesicles (MVs) in the presence of the serum. In this study, MVs were further characterized using a proteomic strategy and potential functions of the MVs were determined. MV proteins isolated from six WMyo populations were separated using two-dimensional differential gel electrophoresis...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28374123/blood-flow-can-signal-during-angiogenesis-not-only-through-mechanotransduction-but-also-by-affecting-growth-factor-distribution
#17
Siavash Ghaffari, Richard L Leask, Elizabeth A V Jones
Growth factors, such as VEGF, promote the sprouting of new blood vessels. Growth factors are generally produced far from the endothelium, and the transport of these proteins is often assumed to occur through diffusion. When sprouting occurs in a perfused vascular bed, however, interstitial flow is present that can modify protein transport. We recently developed a technique to analyze flow dynamics and vascular remodeling simultaneously in avian embryos. In this study, we extend our technique to model interstitial flow through the porous matrix of the mesenchymal tissue and use this to investigate how flow in the blood vessels affects the distribution of growth factors in the mesenchyme, using VEGF as a prototypical angiogenic molecule...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28283856/effects-of-nintedanib-on-the-microvascular-architecture-in-a-lung-fibrosis-model
#18
Maximilian Ackermann, Yong Ook Kim, Willi L Wagner, Detlef Schuppan, Cristian D Valenzuela, Steven J Mentzer, Sebastian Kreuz, Detlef Stiller, Lutz Wollin, Moritz A Konerding
Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the impact of nintedanib on microvascular architecture in a pulmonary fibrosis model. Lung fibrosis was induced in C57Bl/6 mice by intratracheal bleomycin (0.5 mg/kg). Nintedanib was started after the onset of lung pathology (50 mg/kg twice daily, orally). Micro-computed tomography was performed via volumetric assessment. Static lung compliance and forced vital capacity were determined by invasive measurements...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28271280/rcan1-4-regulates-vegfr-2-internalisation-cell-polarity-and-migration-in-human-microvascular-endothelial-cells
#19
Ahmad F Alghanem, Emma L Wilkinson, Maxine S Emmett, Mohammad A Aljasir, Katherine Holmes, Beverley A Rothermel, Victoria A Simms, Victoria L Heath, Michael J Cross
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is highly upregulated in response to VEGF in human endothelial cells in contrast to RCAN1.1 and is essential for efficient endothelial cell migration and tubular morphogenesis. Here, we show that RCAN1...
August 2017: Angiogenesis
https://www.readbyqxmd.com/read/28197812/mcpip1-contributes-to-clear-cell-renal-cell-carcinomas-development
#20
Janusz Ligeza, Paulina Marona, Natalia Gach, Barbara Lipert, Katarzyna Miekus, Waclaw Wilk, Janusz Jaszczynski, Andrzej Stelmach, Agnieszka Loboda, Jozef Dulak, Wojciech Branicki, Janusz Rys, Jolanta Jura
Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1, is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the stability of transcripts coding for proinflammatory cytokines and controlling activity of transcription factors, such as NF-κB and AP1. We found that MCPIP1 transcript and protein levels are strongly downregulated in clear cell renal cell carcinoma (ccRCC) samples, which were derived from patients surgically treated for renal cancer compared to surrounded normal tissues...
August 2017: Angiogenesis
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