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Angiogenesis

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https://www.readbyqxmd.com/read/27896475/an-exploratory-association-of-polymorphisms-in-angiogenesis-related-genes-with-susceptibility-clinical-response-and-toxicity-in-gastrointestinal-stromal-tumors-receiving-sunitinib-after-imatinib-failure
#1
Gloria Ravegnini, Margherita Nannini, Corrado Zenesini, Vittorio Simeon, Giulia Sammarini, Milena Urbini, Lidia Gatto, Maristella Saponara, Guido Biasco, Maria A Pantaleo, Nicola Venturoli, Patrizia Hrelia, Sabrina Angelini
The angiogenic pathway plays a pivotal role in tumor growth, invasiveness and metastasis. The most important actors in the angiogenic pathway are VEGFA and its receptors VEGFR1, 2 and 3. These genes are polymorphic, and the presence of single nucleotide polymorphisms may result in angiogenic deregulation. Herein, we hypothesized that germline variants may affect sunitinib efficacy (TTP and OS) and/or toxicity. Therefore, we investigated 19 polymorphisms, in four genes, in 54 GIST patients, treated with second-line sunitinib and 147 healthy controls...
November 28, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27873103/differential-regulation-of-angiogenic-cellular-processes-and-claudin-5-by-histamine-and-vegf-via-pi3k-signaling-transcription-factor-snai2-and-interleukin-8
#2
Johanna P Laakkonen, Jari P Lappalainen, Thomas L Theelen, Pyry I Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U Kaikkonen, Judith C Sluimer, Seppo Ylä-Herttuala
AIMS: Histamine and vascular endothelial growth factor A (VEGF) are central regulators in vascular pathologies. Their gene regulation leading to vascular remodeling has remained obscure. In this study, EC regulation mechanisms of histamine and VEGF were compared by RNA sequencing of primary endothelial cells (ECs), functional in vitro assays and in vivo permeability mice model. METHODS AND RESULTS: By RNA sequencing, similar transcriptional alterations of genes involved in activation of primary ECs, cell proliferation and adhesion were observed between histamine and VEGF...
November 21, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27853962/enhanced-peripheral-dopamine-impairs-post-ischemic-healing-by-suppressing-angiotensin-receptor-type-1-expression-in-endothelial-cells-and-inhibiting-angiogenesis
#3
Chandrani Sarkar, Ramesh K Ganju, Vincent J Pompili, Debanjan Chakroborty
Increased circulating catecholamines have been linked with cardiovascular anomalies as well as with peripheral vascular diseases. Although the roles of epinephrine and norepinephrine have received considerable attention, the role of the other catecholamine, dopamine, has been less studied. Since dopamine is a potent endogenous inhibitor of angiogenesis and as angiogenesis is essential for ischemic healing, we therefore studied the role played by dopamine during ischemic healing using dopamine D2 receptor knockout (KOD2) mice...
November 16, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27807692/tissue-factor-is-an-angiogenic-specific-receptor-for-factor-vii-targeted-immunotherapy-and-photodynamic-therapy
#4
Zhiwei Hu, Jijun Cheng, Jie Xu, Wolfram Ruf, Charles J Lockwood
Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls...
November 2, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27787629/lymphangiogenesis-in-rat-asthma-model
#5
Aigul Moldobaeva, John Jenkins, Qiong Zhong, Elizabeth M Wagner
Although bronchial angiogenesis has been well documented in allergic asthma, lymphangiogenesis has not been widely studied. Therefore, we evaluated changes in lung lymphatics in a rat model of allergen-induced asthma using house dust mite (Der p 1; 100 μg/challenge). Additionally, properties of isolated lung lymphatic endothelial cells (CD45(-), CD141(+), LYVE-1(+), Prox-1(+)) were studied in vitro. Three weeks after the onset of intranasal allergen exposure (twice-weekly), an increase in the number of lung lymphatic vessels was measured (34% increase) by lung morphometry...
October 27, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27743086/bp-1t-an-antiangiogenic-benzophenone-thiazole-pharmacophore-counteracts-hif-1-signalling-through-p53-mdm2-mediated-hif-1%C3%AE-proteasomal-degradation
#6
Prabhu Thirusangu, V Vigneshwaran, T Prashanth, B R Vijay Avin, Vikas H Malojirao, H Rakesh, Shaukath Ara Khanum, Riaz Mahmood, B T Prabhakar
Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its expression is positively correlated with poor prognosis for cancer patients, HIF-1α is one of the most convincing anticancer targets. BP-1T is a novel antiproliferative agent with promising antiangiogenic effects. In the present study, the molecular mechanism underlying cytotoxic/antiangiogenic effects of BP-1T on tumour/non-tumour angiogenesis was evaluated...
October 14, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27699500/identification-of-hif-2%C3%AE-regulated-genes-that-play-a-role-in-human-microvascular-endothelial-sprouting-during-prolonged-hypoxia-in-vitro
#7
Tessa D Nauta, Marloes van den Broek, Sue Gibbs, Tineke C T M van der Pouw-Kraan, Cees B Oudejans, Victor W M van Hinsbergh, Pieter Koolwijk
During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α partially restores sprout formation. The present study identifies novel HIF-2α-target genes that may regulate endothelial sprouting during prolonged hypoxia. The gene expression profile of primary human microvascular endothelial cells (hMVECs) that were cultured at 20 % oxygen was compared to hMVECs that were cultured at 1 % oxygen for 14 days by using genome-wide RNA-sequencing...
October 3, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27695972/aliskiren-decreases-oxidative-stress-and-angiogenic-markers-in-retinal-pigment-epithelium-cells
#8
Sónia Simão, Daniela F Santos, Gabriela A Silva
There is growing evidence on the role of ocular renin-angiotensin system (RAS) in the development of diabetic retinopathy (DR), particularly due to the trigger of oxidative stress and angiogenesis. Despite this there is no effective RAS-based therapy in DR capable of preventing retinal damage induced by RAS activation. We recently described that retinal pigment epithelium (RPE) cells express the main components of the RAS. We here propose to investigate the role of glucose upon the retinal RAS and whether aliskiren, a direct renin inhibitor, protects RPE cells from angiogenesis and oxidative stress...
October 1, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27679502/androgens-modulate-male-derived-endothelial-cell-homeostasis-using-androgen-receptor-dependent-and-receptor-independent-mechanisms
#9
Verónica Torres-Estay, Daniela V Carreño, Patricia Fuenzalida, Anica Watts, Ignacio F San Francisco, Viviana P Montecinos, Paula C Sotomayor, John Ebos, Gary J Smith, Alejandro S Godoy
BACKGROUND: Sex-related differences in the role of androgen have been reported in cardiovascular diseases and angiogenesis. Moreover, androgen receptor (AR) has been causally involved in the homeostasis of human prostate endothelial cells. However, levels of expression, functionality and biological role of AR in male- and female-derived human endothelial cells (ECs) remain poorly characterized. The objectives of this work were (1) to characterize the functional expression of AR in male- and female-derived human umbilical vein endothelial cell (HUVEC), and (2) to specifically analyze the biological effects of DHT, and the role of AR on these effects, in male-derived HUVECs (mHUVECs)...
September 27, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27582011/contrast-enhanced-ct-imaging-in-patients-with-chronic-kidney-disease
#10
Saskia von Stillfried, Jonas C Apitzsch, Josef Ehling, Tobias Penzkofer, Andreas H Mahnken, Ruth Knüchel, Jürgen Floege, Peter Boor
Renal microvascular rarefaction characterizes chronic kidney disease (CKD). In murine models of CKD, micro-CT imaging reflected capillary rarefaction using quantification of renal relative blood volume (rBV). In addition, micro-CT imaging revealed morphological alterations of the intrarenal vasculature including reduced vascular branching and lumen diameter. Here, we retrospectively quantified rBV in contrast-enhanced CT angiography in patients and found that, compared to non-CKD patients, those with CKD and renal fibrosis had significantly reduced rBV in the renal cortex...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27464987/regulation-of-lymphangiogenesis-in-the-diaphragm-by-macrophages-and-vegfr-3-signaling
#11
Alexandra M Ochsenbein, Sinem Karaman, Steven T Proulx, Rhea Goldmann, Jyothi Chittazhathu, Athanasia Dasargyri, Chloé Chong, Jean-Christophe Leroux, E Richard Stanley, Michael Detmar
Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earliest lymphatic vessel differentiation and development has been investigated in much detail, less is known about the control and timing of lymphatic vessel maturation in different organs, which often occurs postnatally. We investigated the time course of lymphatic vessel development on the pleural side of the diaphragmatic muscle in mice, the so-called submesothelial initial diaphragmatic lymphatic plexus...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27387982/prostate-specific-membrane-antigen-psma-mediated-laminin-proteolysis-generates-a-pro-angiogenic-peptide
#12
Rebecca E Conway, Camilo Rojas, Jesse Alt, Zora Nováková, Spencer M Richardson, Tori C Rodrick, Julio L Fuentes, Noah H Richardson, Jonathan Attalla, Samantha Stewart, Beshoy Fahmy, Cyril Barinka, Mallika Ghosh, Linda H Shapiro, Barbara S Slusher
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase expressed in a number of tissues. PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate. PSMA expression is also progressively upregulated in prostate cancer where it correlates with tumor progression as well as in tumor vasculature, where it regulates angiogenesis...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27380212/celecoxib-and-octreotide-synergistically-ameliorate-portal-hypertension-via-inhibition-of-angiogenesis-in-cirrhotic-rats
#13
Jin-Hang Gao, Shi-Lei Wen, Shi Feng, Wen-Juan Yang, Yao-Yao Lu, Huan Tong, Rui Liu, Shi-Hang Tang, Zhi-Yin Huang, Ying-Mei Tang, Jin-Hui Yang, Hui-Qi Xie, Cheng-Wei Tang
Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological treatment, no efficient medication or regime has been explored to treat the early stage of cirrhosis when angiogenesis is initiated or overwhelming. In this study, we explored an anti-angiogenesis effort through non-cytotoxic drugs octreotide and celecoxib to treat early stage of cirrhotic portal hypertension in an animal model. Peritoneal injection of thioacetamide (TAA) was employed to induce liver cirrhosis in rats...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27338829/a-non-canonical-role-for-desmoglein-2-in-endothelial-cells-implications-for-neoangiogenesis
#14
Lisa M Ebert, Lih Y Tan, M Zahied Johan, Kay Khine Myo Min, Michaelia P Cockshell, Kate A Parham, Kelly L Betterman, Paceman Szeto, Samantha Boyle, Lokugan Silva, Angela Peng, YouFang Zhang, Andrew Ruszkiewicz, Andrew C W Zannettino, Stan Gronthos, Simon Koblar, Natasha L Harvey, Angel F Lopez, Mark Shackleton, Claudine S Bonder
Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the junctional stability to tolerate mechanical stress. However, one member of this family, DSG2, is emerging as a protein with additional biological functions on a broader range of cells. Here we reveal that DSG2 is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts [endothelial cells (ECs)] in human tissue from healthy individuals and cancer patients...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27325285/persistent-infiltration-and-pro-inflammatory-differentiation-of-monocytes-cause-unresolved-inflammation-in-brain-arteriovenous-malformation
#15
Rui Zhang, Zhenying Han, Vincent Degos, Fanxia Shen, Eun-Jung Choi, Zhengda Sun, Shuai Kang, Michael Wong, Wan Zhu, Lei Zhan, Helen M Arthur, S Paul Oh, Marie E Faughnan, Hua Su
An abnormally high number of macrophages are present in human brain arteriovenous malformations (bAVM) with or without evidence of prior hemorrhage, causing unresolved inflammation that may enhance abnormal vascular remodeling and exacerbate the bAVM phenotype. The reasons for macrophage accumulation at the bAVM sites are not known. We tested the hypothesis that persistent infiltration and pro-inflammatory differentiation of monocytes in angiogenic tissues increase the macrophage burden in bAVM using two mouse models and human monocytes...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27278471/pigment-epithelium-derived-factor-pedf-a-novel-trophoblast-derived-factor-limiting-feto-placental-angiogenesis-in-late-pregnancy
#16
Jelena Loegl, Erika Nussbaumer, Ursula Hiden, Alejandro Majali-Martinez, Nassim Ghaffari-Tabrizi-Wizy, Silvija Cvitic, Ingrid Lang, Gernot Desoye, Berthold Huppertz
The rapidly expanding feto-placental vasculature needs tight control by paracrine and endocrine mechanisms. Here, we focused on paracrine influence by trophoblast, the placental epithelium. We aimed to identify differences in regulation of feto-placental angiogenesis in early versus late pregnancy. To this end, the effect of conditioned media (CM) from early and late pregnancy human trophoblast was tested on network formation, migration and proliferation of human feto-placental endothelial cells. Only CM of late pregnancy trophoblast reduced network formation and migration...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27245991/association-of-endothelial-proliferation-with-the-magnitude-of-weight-loss-during-calorie-restriction
#17
Katarzyna Korybalska, Ewelina Swora-Cwynar, Joanna Łuczak, Alina Kanikowska, Natasza Czepulis, Rafał Rutkowski, Andrzej Bręborowicz, Marian Grzymisławski, Janusz Witowski
OBJECTIVES: Substantial weight loss through intense dietary regimens is thought to ameliorate endothelial dysfunction in obesity. It is less clear whether similar improvements can be achieved with modest dietary interventions. This study aimed to identify the parameters of endothelial cell status in obesity that are affected by mild calorie restriction. METHODS: Human umbilical vein endothelial cells (EA.hy926 line) in culture were exposed pairwise to serum from 57 individuals with simple obesity (BMI > 30 kg/m(2)) collected before and after 8-week dietary intervention with energy deficit of 300-500 kcal/day...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27236773/circulating-angiopoietin-2-levels-in-children-and-adolescents-with-type-1-diabetes-mellitus-relation-to-carotid-and-aortic-intima-media-thickness
#18
Mohamed Abo El-Asrar, Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, AlShaimaa Abo Bakr
BACKGROUND: Angiopoietin-2 is a growth factor involved in the pathophysiology of vascular and inflammatory diseases such as arteriosclerosis. Carotid or aortic scans provide noninvasive screening tools for assessment of preclinical atherosclerosis in high-risk children. AIM: We assessed serum angiopoietin-2 in children and adolescents with type 1 diabetes mellitus as a potential marker for vascular complications in relation to glycemic control, inflammation and vascular structure...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27234973/aflibercept-exhibits-vegf-binding-stoichiometry-distinct-from-bevacizumab-and-does-not-support-formation-of-immune-like-complexes
#19
Douglas A MacDonald, Joel Martin, Kathir K Muthusamy, Jiann-Kae Luo, Erica Pyles, Ashique Rafique, Tammy Huang, Terra Potocky, Yang Liu, Jingtai Cao, Françoise Bono, Nathalie Delesque, Pierre Savi, John Francis, Ali Amirkhosravi, Todd Meyer, Carmelo Romano, Meredith Glinka, George D Yancopoulos, Neil Stahl, Stanley J Wiegand, Nicholas Papadopoulos
Anti-vascular endothelial growth factor (VEGF) therapies have improved clinical outcomes for patients with cancers and retinal vascular diseases. Three anti-VEGF agents, pegaptanib, ranibizumab, and aflibercept, are approved for ophthalmic indications, while bevacizumab is approved to treat colorectal, lung, and renal cancers, but is also used off-label to treat ocular vascular diseases. The efficacy of bevacizumab relative to ranibizumab in treating neovascular age-related macular degeneration has been assessed in several trials...
July 2016: Angiogenesis
https://www.readbyqxmd.com/read/27216867/ephrinb2-ephb4-pathway-in-postnatal-angiogenesis-a-potential-therapeutic-target-for-ischemic-cardiovascular-disease
#20
REVIEW
Du Yang, Chunna Jin, Hong Ma, Mingyuan Huang, Guo-Ping Shi, Jianan Wang, Meixiang Xiang
Ischemic cardiovascular disease remains one of the leading causes of morbidity and mortality in the world. Proangiogenic therapy appears to be a promising and feasible strategy for the patients with ischemic cardiovascular disease, but the results of preclinical and clinical trials are limited due to the complicated mechanisms of angiogenesis. Facilitating the formation of functional vessels is important in rescuing the ischemic cardiomyocytes. EphrinB2/EphB4, a novel pathway in angiogenesis, plays a critical role in both microvascular growth and neovascular maturation...
July 2016: Angiogenesis
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