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Growth Hormone & IGF Research

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https://www.readbyqxmd.com/read/29459140/corrigendum-to-assessment-of-quality-of-life-on-4-year-growth-hormone-therapy-in-japanese-patients-with-adult-growth-hormone-deficiency-a-post-marketing-multicenter-observational-study-growth-hormon-igf-res-36-2017-36-43
#1
Hitoshi Ishii, Akira Shimatsu, Hiromi Nishinaga, Osamu Murai, Kazuo Chihara
No abstract text is available yet for this article.
February 16, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29459141/a-descriptive-study-on-selected-growth-parameters-and-growth-hormone-receptor-gene-in-healthy-young-adults-from-the-american-midwest
#2
Samantha N Hartin, Waheeda A Hossain, Ann M Manzardo, Shaquanna Brown, Paula J Fite, Marco Bortolato, Merlin G Butler
CONTEXT: The first study of growth hormone receptor (GHR) genotypes in healthy young adults in the United States attending a Midwestern university and impact on selected growth parameters. OBJECTIVE: To describe the frequency of GHR genotypes in a sample of healthy young adults from the United States attending a university in the Midwest and analyze the relationship between GHR genotypes and selected growth parameters. DESIGN: Saliva was collected from 459 healthy young adults (237 females, 222 males; age range = 18-25 y) and DNA isolated for genotyping of GHR alleles (fl/fl, fl/d3, or d3/d3)...
February 12, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452886/shifting-the-igf-axis-an-age-related-decline-in-human-tear-igf-1-correlates-with-clinical-signs-of-dry-eye
#3
Roshni Patel, Meifang Zhu, Danielle M Robertson
OBJECTIVE: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1. DESIGN: Tear levels of IGF-1 were measured in 41 healthy, human volunteers without any reported symptoms of dry eye...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452885/somatolactogens-and-diabetic-retinopathy
#4
REVIEW
Kevin Christian Bermea, Alejandro Rodríguez-García, Andrew Tsin, Hugo Alberto Barrera-Saldaña
IMPORTANCE: Diabetic retinopathy (DR) is one of the most common of all diabetic complications. The number of people with DR in the United States is expected to increase to 16 million by 2050. DR is the leading cause of blindness among working-age adults in many different countries, including the United States. In later DR stages, neovascularization is associated with extensive retinal capillary non-perfusion and vitreo-proliferation leading to retinal detachment. This neovascularization is orchestrated by an imbalance of growth factors in the retina from which somatolactogens (pituitary growth hormone, GH-N; placental growth hormone, GH-V; prolactin, PRL; and placental lactogen, PL, also referred as chorionic somatomammotropin, CSH), may play an important role...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29398370/depot-specific-and-gh-dependent-regulation-of-igf-binding-protein-4-pregnancy-associated-plasma-protein-a-and-stanniocalcin-2-in-murine-adipose-tissue
#5
Rikke Hjortebjerg, Darlene E Berryman, Ross Comisford, Edward O List, Claus Oxvig, Mette Bjerre, Jan Frystyk, John J Kopchick
INTRODUCTION: Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF)-I action through proteolytic cleavage of IGF binding protein-4 (IGFBP-4). Recently, stanniocalcin-2 (STC2) was discovered as an inhibitor of PAPP-A. Most members of the IGF system are expressed in adipose tissue (AT), but there is a relative paucity of information on the distribution of IGFBP-4, PAPP-A, and STC2 in different AT depots. Since IGF-I expression in AT is highly GH-dependent, we used bovine GH transgenic (bGH) and GH receptor knockout (GHR-/-) mice to investigate AT depot-specific expression patterns of IGFBP-4, PAPP-A, and STC2, and whether the regulation is GH-dependent...
February 2, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29422321/broad-variability-in-pharmacokinetics-of-gh-following-rhgh-injections-in-children
#6
Elena Lundberg, Björn Andersson, Berit Kriström, Sten Rosberg, Kerstin Albertsson-Wikland
OBJECTIVE: Daily subcutaneous self-injection of GH is used worldwide to treat short stature in childhood; longitudinal data on the impact of this regimen on GH-uptake are lacking. DESIGN: Children with/without GH-deficiency participating in clinical trials were followed prospectively (≤8 times). Blood was sampled pre-GH-injection (dose GH33/GH67 μg/kg) and either every 30 min thereafter for 24 h (Experimental-setting; 59 GH-curves/15 children); or every 2 h thereafter for 16 h (Clinical-setting; 429 GH-curves/117 children)...
February 1, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29398371/gh-directly-stimulates-ucp3-expression
#7
Misa Hayashi, Kumi Futawaka, Midori Matsushita, Rie Koyama, Yue Fun, Yuki Fukuda, Ayaka Nushida, Syoko Nezu, Tetsuya Tagami, Kenji Moriyama
OBJECTIVE: We evaluated the direct action of GH signaling in energy homeostasis in myocytes. DESIGN: We investigated the GH-induced expression of UCP3 in human embryonic kidney 293 cells, human H-EMC-SS chondrosarcoma cells, murine C2C12 skeletal muscle myoblasts, and rat L6 skeletal muscle cells, as well as its direct effect on the GHR/JAK/STAT5 pathway using a combination of a reporter assay, real-time quantitative polymerase chain reaction, and western blotting...
January 31, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29395967/factors-correlated-with-serum-insulin-like-growth-factor-i-levels-in-health-check-up-subjects
#8
Ryusaku Matsumoto, Masafumi Koga, Soji Kasayama, Hidenori Fukuoka, Genzo Iguchi, Yukiko Odake, Kenichi Yoshida, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Wataru Ogawa, Yutaka Takahashi
BACKGROUND: Most of circulating IGF-I is derived from the liver and circulating IGF-I levels are decreased in several pathological conditions, such as liver cirrhosis, uncontrolled diabetes, renal failure, and malnutrition. However, it has not fully been elucidated which factors modify IGF-I level in a physiological condition. OBJECTIVE: To identify the factors which are associated with circulating IGF-I levels. DESIGN: Cross-sectional study...
January 30, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29311008/preface
#9
EDITORIAL
Carlos Montúfar, Ximena Córdova, Santiago Gangotena, Diego Quiroga, Michelle Grunauer
No abstract text is available yet for this article.
December 28, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29295769/foreword-from-the-guest-editors
#10
EDITORIAL
Jaime Guevara-Aguirre, Enrique Teran, Ron Rosenfeld
No abstract text is available yet for this article.
December 28, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29291885/short-children-born-small-for-gestational-age-outcomes-in-the-era-of-growth-hormone-therapy
#11
Santina A Zanelli, Alan D Rogol
Small-for-gestational age (SGA) infants are at risk for short and long term medical and metabolic complications. Most SGA infants (85-90%) demonstrate spontaneous catch-up growth, typically in the first year after birth. Although catch-up growth (CUG) is a desired goal, it is important to note if CUG is too rapid the infants are at increased risk for insulin resistance and type 2 diabetes mellitus as they become adults. On the flip side, infants who do not exhibit CUG are also at increased risk of adverse adult outcomes including those for cardiovascular disease, insulin resistance and type 2 diabetes mellitus, neurodevelopmental and cognitive impairments, in addition to adult short stature...
December 28, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29306561/insulin-resistance-depends-on-gh-counter-regulation-in-two-syndromes-of-short-stature
#12
Jaime Guevara-Aguirre, Alexandra Guevara, Marisol Bahamonde
Specific phenotypic features of subjects affected with genetic syndromes depend on peculiarities of expression of each discrete mutation and on extent of its divergence from normal physiology. In this context, and when studying the GH/IGF-I axis of subjects with two different syndromes that include severe short stature (SSS), we noticed different metabolic phenotypes in each cohort. Subjects with Laron syndrome (LS), who have GH insensitivity (GHI), display obesity, increased body fat, enhanced insulin sensitivity and diminished incidence of diabetes mellitus...
December 20, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29306560/treatment-of-growth-failure-in-the-absence-of-gh-signaling-the-ecuadorian-experience
#13
Jaime Guevara-Aguirre, Alexandra Guevara, Carolina Guevara
Recombinant human insulin-like growth factor-1 (rhIGF-1) treatment studies of growth failure in absence of growth hormone (GH) signaling (GH insensitivity -GHI, Laron syndrome -LS, GH Receptor deficiency -GHRD) have taken place in many locations around the globe. Results from these trials are comparable, and slight differences reported can be attributed to specific circumstances at different research sites. rhIGF-I treatment studies of GHI in Ecuador included various trials performed on children belonging to the largest and only homogeneous cohort of subjects with this condition in the world...
December 20, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29279183/increased-fibrosis-a-novel-means-by-which-gh-influences-white-adipose-tissue-function
#14
Lara A Householder, Ross Comisford, Silvana Duran-Ortiz, Kevin Lee, Katie Troike, Cody Wilson, Adam Jara, Mitchell Harberson, Edward O List, John J Kopchick, Darlene E Berryman
OBJECTIVE: White adipose tissue (WAT) fibrosis - the buildup of extracellular matrix (ECM) proteins, primarily collagen - is now a recognized hallmark of tissue dysfunction and is increased with obesity and lipodystrophy. While growth hormone (GH) is known to increase collagen in several tissues, no previous research has addressed its effect on ECM in WAT. Thus, the purpose of this study is to determine if GH influences WAT fibrosis. DESIGN: This study examined WAT from four distinct strains of GH-altered mice (bGH and GHA transgenic mice as well as two tissue specific GH receptor gene disrupted lines, fat growth hormone receptor knockout or FaGHRKO and liver growth hormone receptor knockout or LiGHRKO mice)...
December 20, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29277338/hypothalamic-abnormalities-growth-failure-due-to-defects-of-the-ghrh-receptor
#15
Manuel H Aguiar-Oliveira, Caridad Davalos, Viviane C Campos, Luiz A Oliveira Neto, Cindi G Marinho, Carla R P Oliveira
Several acquired or congenital hypothalamic abnormalities may cause growth failure (GF). We described two of these congenital abnormalities. First, a case of CHARGE syndrome, an epigenetic disorder mostly caused by heterozygous mutations in the gene encoding CHD7, a chromatin remodeling protein, causing several malformations, some life-threatening, with additional secondary hypothalamus-hypophyseal dysfunction, including GF. Second, a cohort of individuals with genetic isolated severe GH deficiency (IGHD), due to a homozygous mutation in the GH-releasing hormone (GHRH) receptor gene described in Itabaianinha County, in northeast Brazil...
December 20, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29289483/challenges-and-future-for-the-delivery-of-growth-hormone-therapy
#16
Andrés Caicedo, Ron Rosenfeld
Growth hormone (GH) has multiple roles in sustaining human development and homeostasis. Its pulsatile secretion stimulates growth and contributes to an equilibrium in a process tightly regulated and coordinated by many organs. GH deficiency is a medical condition affecting all ages, with not only significant consequences in the health of the patient but also impact on the quality of life. This review gathers the different strategies used today with a glance at future technologies to treat GH deficiency. We present key aspects for consideration when developing new methods to deliver GH, mimicking or replacing its pulsatile activity...
December 17, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29274847/comparison-between-euglycemic-hyperinsulinemic-clamp-and-surrogate-indices-of-insulin-sensitivity-in-children-with-growth-hormone-deficiency
#17
Alessandro Ciresi, Valentina Guarnotta, Giuseppe Pizzolanti, Carla Giordano
OBJECTIVE: Data about the impact of growth hormone treatment (GHT) on insulin sensitivity in children are quite controversial, due to the different surrogate indices that have been used. DESIGN: We evaluated insulin sensitivity through the euglycemic hyperinsulinemic clamp, considered the gold standard technique, in 23 children affected by growth hormone deficiency (GHD) at baseline and after 12months of GHT and in 12 controls with short stature at baseline, and we compared the clamp-derived index (M-value) with the most commonly used surrogate index of insulin sensitivity, as ISI Matsuda, and with circulating plasma markers of insulin sensitivity, as adiponectin and resistin levels...
December 13, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29249623/growth-hormone-and-insulin-like-growth-factor-i-axis-in-type-1-diabetes
#18
Bimota Nambam, Desmond Schatz
The precise mechanisms relating type 1 diabetes (T1D) and poor glycemic control to the axis of growth hormone (GH), insulin like growth factor- I (IGF-I), and IGF binding protein-3 (IGFBP-3) remain to be definitively determined. GH resistance with low IGF-I as is frequently seen in patients with T1D is often related to portal hypoinsulization, and lack of upregulation of GH receptors. There are conflicting reports of the effect of a dysregulated GH/IGF-I axis on height in children and adolescents with T1D, as well as on chronic complications...
December 13, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29395968/gh-and-ghr-signaling-in-human-disease
#19
Jaime Guevara-Aguirre, Alexandra Guevara, Iván Palacios, Mónica Pérez, Patricio Prócel, Enrique Terán
Along with its inherent properties in growth promotion, cell division and regeneration, growth hormone (GH) exerts a variety of miscellaneous and widespread actions on the human body after binding to its receptor (GHR). Indeed, GH influences the metabolism of carbohydrates, lipids and proteins; shapes body composition, influences cardiovascular profile, quality of life, and induces other direct and indirect physiologic effects. Besides this salutary actions, GH and its derived peptide insulin-like growth factor-I (IGF-I), main product of the GH/GHR interaction, have been implicated in the genesis of diseases such as cancer and insulin-resistant diabetes...
December 12, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29249625/genetic-disorders-of-gh-action-pathway
#20
Horacio M Domené, Gustavo Fierro-Carrión
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, and lack of IGF-I response to GH treatment, IGF-I resistance is characterized by elevated IGF-I levels with normal/high GH levels. Several genetic defects are responsible for impairment of GH and IGF-I actions resulting in short stature that could affect intrauterine growth or be present in the postnatal period. The genetic defects affecting GH and/or IGF-I action can be divided into five different groups: GH insensitivity by defects affecting the GH receptor (GHR), the intracellular GH signaling pathway (STAT5B, STAT3, IKBKB, IL2RG, PIK3R1), the synthesis of insulin-like growth factors (IGF1, IGF2), the transport/bioavailability of IGFs (IGFALS, PAPPA2), and defects affecting IGF-I sensitivity (IGF1R)...
December 12, 2017: Growth Hormone & IGF Research
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