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Growth Hormone & IGF Research

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https://www.readbyqxmd.com/read/29723762/characterization-of-igf1-and-igf2-genes-during-maraena-whitefish-coregonus-maraena-ontogeny-and-the-effect-of-temperature-on-embryogenesis-and-igf-expression
#1
Mareen Nipkow, Elisa Wirthgen, Peter Luft, Alexander Rebl, Andreas Hoeflich, Tom Goldammer
The insulin-like growth factors IGF-1 and IGF-2 play important roles in the growth, development, and metabolism of teleost fish. We isolated cDNA sequences of igf1, and igf2 genes from maraena whitefish. We quantified the mRNA and protein expressions of IGFs in different tissues of marketable juvenile maraena whitefish. Moreover, we analyzed the gene expression profiles during maraena whitefish development from unfertilized egg to fingerling and examined the effect of incubation temperature on igf1, and igf2 gene expression during embryonic and early larval development...
April 25, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29702359/combined-simultaneous-arginine-clonidine-stimulation-test-timing-of-peak-growth-hormone-gh-concentration-and-correlation-with-clinical-indices-of-gh-status
#2
Nandini Bhat, Eric Dulmovits, Andrew Lane, Catherine Messina, Thomas Wilson
BACKGROUND: The aims of this study were to determine if it is possible to truncate a combined simultaneous arginine clonidine stimulation test, and to correlate the outcome of the test with clinical indices of GH status. METHODS: Charts of subjects who underwent a combined simultaneous arginine clonidine stimulation test between January 1, 2007 and August 31, 2016 were reviewed. RESULTS: 131/203 (64.5%) tests performed in children with growth failure demonstrated a peak GH ≥ 10 ng/ml...
April 7, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29653372/history-and-clinical-implications-of-papp-a2-in-human-growth-when-reflecting-on-idiopathic-short-stature-leads-to-a-specific-and-new-diagnosis-understanding-the-concept-of-low-igf-i-availability
#3
LETTER
Jesús Argente, Luis A Pérez-Jurado
As a result of our publication of the first patients with short stature due to a mutation in the gene for PAPP-A2 the question, "Why did you continue to study these patients when they were not more than 2 SDS below normal?" has been proposed surprisingly frequently. We would like to communicate our opinions on why these patients were studied and share the experience on how this process took place. In addition, the choice of treatment is also discussed. We believe that this discovery process is a good example of good clinical practice and international collaboration...
April 5, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29626795/growth-hormone-facilitates-5-azacytidine-induced-myogenic-but-inhibits-5-azacytidine-induced-adipogenic-commitment-in-c3h10t1-2-mesenchymal-stem-cells
#4
Dan Jia, Weijiang Zheng, Honglin Jiang
The C3H10T1/2 cells are considered mesenchymal stem cells (MSCs) because they can be induced to become the progenitor cells for myocytes, adipocytes, osteoblasts, and chondrocytes by the DNA methyltransferase inhibitor 5'-azacytidine. In this study, we determined the effect of growth hormone (GH) on the myogenic and adipogenic lineage commitment in C3H10T1/2 cells. The C3H10T1/2 cells were treated with recombinant bovine GH in the presence or absence of 5'-azacytidine for 4 days. The myogenic commitment in C3H10T1/2 cells was assessed by immunostaining them for MyoD, the marker for myoblasts, and by determining their capacity to differentiate into the multinucleated myotubes...
March 28, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29601998/biomarkers-of-gh-action-in-children-and-adults
#5
REVIEW
Katharina Schilbach, Daniel S Olsson, Margaret C S Boguszewski, Martin Bidlingmaier, Gudmundur Johannsson, Jens-Otto Lunde Jørgensen
Growth hormone (GH) and IGF-I levels in serum are used as biomarkers in the diagnosis and management of GH-related disorders but have not been subject to structured validation. Auxological parameters in children and changes in body composition in adults, as well as metabolic parameters and patient related outcomes are used as clinical and surrogate endpoints. New treatment options, such as long acting GH and GH antagonists, require reevaluation of the currently used biochemical biomarkers. This article will review biomarkers, surrogate endpoints and clinical endpoints related to GH treatment in children and adults as well as in acromegaly...
March 20, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29571594/occurrence-of-neoplasms-in-individuals-with-congenital-severe-gh-deficiency-from-the-itabaianinha-kindred
#6
Cindi G Marinho, Lívia M Mermejo, Roberto Salvatori, João A Assirati, Carla R P Oliveira, Elenilde G Santos, Ângela C G B Leal, Cynthia S Barros-Oliveira, Nayra P Damascena, Carlos A Lima, Catarine T Farias, Ayrton C Moreira, Manuel H Aguiar-Oliveira
Growth hormone (GH) and the insulin-like growth factor I (IGF-I) have cell proliferative and differentiation properties. Whether these hormones have a role in mutagenesis is unknown. Nevertheless, severe IGF-I deficiency seems to confer protection against the development of neoplasms. Here, we report five cases of adult patients with severe and congenital isolated GH deficiency (IGHD) due to the c.57+1G>A mutation in the GHRH receptor gene, who developed tumors. Four GH-naïve subjects presented skin tumors: a 42-year-old man with a fibroepithelial polyp, a 53-year-old woman and two men (59 and 56 years old) with epidermoid skin cancers...
March 12, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29679919/the-effect-of-growth-hormone-on-bioactive-igf-in-overweight-obese-women
#7
Laura E Dichtel, Mette Bjerre, Melanie Schorr, Miriam A Bredella, Anu V Gerweck, Brian M Russell, Jan Frystyk, Karen K Miller
OBJECTIVE: Overweight/obesity is characterized by decreased growth hormone (GH) secretion whereas circulating IGF-I levels are less severely reduced. Yet, the activity of the circulating IGF-system appears to be normal in overweight/obese subjects, as estimated by the ability of serum to activate the IGF-I receptor in vitro (bioactive IGF). We hypothesized that preservation of bioactive IGF in overweight/obese women is regulated by an insulin-mediated suppression of IGF-binding protein-1 (IGFBP-1) and IGFBP-2, and by suppression of IGFBP-3, mediated by low GH...
March 10, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29555234/value-of-early-postoperative-random-growth-hormone-levels-and-nadir-growth-hormone-levels-after-oral-glucose-tolerance-testing-in-acromegaly
#8
Roman Rotermund, Till Burkhardt, Zaina Rohani, Roman Jung, Jens Aberle, Jörg Flitsch
OBJECTIVE: There is no ideal marker to identify residual tumor tissue after surgery in patients with acromegaly. The purpose was to elucidate if early postoperative hormone testing gives reliable information regarding complete resection of a GH-producing pituitary adenoma. DESIGN: Fourty-eight patients undergoing surgery for acromegaly from 04/2013-05/2014 were prospectively examined for random GH, IGF1, and GH levels after oral glucose tolerance testing (OGTT) in the early postoperative phase and on follow-up...
March 8, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29544682/intermittent-hypoxia-suppression-of-growth-hormone-and-insulin-like-growth-factor-i-in-the-neonatal-rat-liver
#9
Charles Cai, Taimur Ahmad, Gloria B Valencia, Jacob V Aranda, Jiliu Xu, Kay D Beharry
OBJECTIVES: Extremely low gestational age neonates with chronic lung disease requiring oxygen therapy frequently experience fluctuations in arterial oxygen saturation or intermittent hypoxia (IH). These infants are at risk for multi-organ developmental delay, reduced growth, and short stature. The growth hormone (GH)/insulin-like growth factor-I (IGF-1) system, an important hormonal regulator of lipid and carbohydrate metabolism, promotes neonatal growth and development. We tested the hypothesis that increasing episodes of IH delay neonatal growth by influencing the GH/IGF-I axis...
March 8, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29398370/depot-specific-and-gh-dependent-regulation-of-igf-binding-protein-4-pregnancy-associated-plasma-protein-a-and-stanniocalcin-2-in-murine-adipose-tissue
#10
Rikke Hjortebjerg, Darlene E Berryman, Ross Comisford, Edward O List, Claus Oxvig, Mette Bjerre, Jan Frystyk, John J Kopchick
INTRODUCTION: Pregnancy-associated plasma protein-A (PAPP-A) stimulates insulin-like growth factor (IGF)-I action through proteolytic cleavage of IGF binding protein-4 (IGFBP-4). Recently, stanniocalcin-2 (STC2) was discovered as an inhibitor of PAPP-A. Most members of the IGF system are expressed in adipose tissue (AT), but there is a relative paucity of information on the distribution of IGFBP-4, PAPP-A, and STC2 in different AT depots. Since IGF-I expression in AT is highly GH-dependent, we used bovine GH transgenic (bGH) and GH receptor knockout (GHR-/-) mice to investigate AT depot-specific expression patterns of IGFBP-4, PAPP-A, and STC2, and whether the regulation is GH-dependent...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29279183/increased-fibrosis-a-novel-means-by-which-gh-influences-white-adipose-tissue-function
#11
Lara A Householder, Ross Comisford, Silvana Duran-Ortiz, Kevin Lee, Katie Troike, Cody Wilson, Adam Jara, Mitchell Harberson, Edward O List, John J Kopchick, Darlene E Berryman
OBJECTIVE: White adipose tissue (WAT) fibrosis - the buildup of extracellular matrix (ECM) proteins, primarily collagen - is now a recognized hallmark of tissue dysfunction and is increased with obesity and lipodystrophy. While growth hormone (GH) is known to increase collagen in several tissues, no previous research has addressed its effect on ECM in WAT. Thus, the purpose of this study is to determine if GH influences WAT fibrosis. DESIGN: This study examined WAT from four distinct strains of GH-altered mice (bGH and GHA transgenic mice as well as two tissue specific GH receptor gene disrupted lines, fat growth hormone receptor knockout or FaGHRKO and liver growth hormone receptor knockout or LiGHRKO mice)...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29274847/comparison-between-euglycemic-hyperinsulinemic-clamp-and-surrogate-indices-of-insulin-sensitivity-in-children-with-growth-hormone-deficiency
#12
Alessandro Ciresi, Valentina Guarnotta, Giuseppe Pizzolanti, Carla Giordano
OBJECTIVE: Data about the impact of growth hormone treatment (GHT) on insulin sensitivity in children are quite controversial, due to the different surrogate indices that have been used. DESIGN: We evaluated insulin sensitivity through the euglycemic hyperinsulinemic clamp, considered the gold standard technique, in 23 children affected by growth hormone deficiency (GHD) at baseline and after 12months of GHT and in 12 controls with short stature at baseline, and we compared the clamp-derived index (M-value) with the most commonly used surrogate index of insulin sensitivity, as ISI Matsuda, and with circulating plasma markers of insulin sensitivity, as adiponectin and resistin levels...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29274846/increased-postnatal-concentrations-of-pro-inflammatory-cytokines-are-associated-with-reduced-igf-i-levels-and-retinopathy-of-prematurity
#13
Gunnel Hellgren, Chatarina Löfqvist, Ingrid Hansen-Pupp, Magnus Gram, Lois E Smith, David Ley, Ann Hellström
OBJECTIVE: Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. DESIGN: The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n=33), non-proliferative ROP (stages 1 and 2; n=10), or proliferative ROP (stage 3, all treated for ROP; n=9)...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29273485/a-first-in-man-phase-1-trial-for-long-acting-transcon-growth-hormone
#14
David Gilfoyle, Eva Mortensen, Eva Dam Christoffersen, Jonathan A Leff, Michael Beckert
TransCon growth hormone (GH) is a sustained-release inactive prodrug consisting of unmodified GH transiently bound to an inert carrier molecule designed to release fully active GH over a one-week period. This was a first-in-man phase 1 randomized trial was to evaluate the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of a single dose of TransCon GH as compared to equivalent doses of daily GH (Omnitrope) or placebo in healthy adults. Forty-four healthy male adults were randomized to 4 cohorts of 11 subjects, distributed in a 7:2:2 ratio (TransCon GH: Omnitrope: placebo)...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29273484/the-igf-p53-connection-in-cancer
#15
Cheryl A Conover
Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29273483/growth-hormone-receptor-ghr-gene-polymorphism-and-scoliosis-in-prader-willi-syndrome
#16
Merlin G Butler, Waheeda Hossain, Maaz Hassan, Ann M Manzardo
OBJECTIVE: A growth hormone receptor (GHR) gene polymorphism impacts sensitivity to endogenous and exogenous growth hormone (GH) to moderate growth and development. Increased sensitivity may accelerate spinal growth and contribute to scoliosis, particularly in GH-deficient and treated populations such as Prader-Willi syndrome (PWS). Therefore, we examined the relationship between GHR genotype and scoliosis (case and control) in PWS cohorts. DESIGN: We utilized a case-control design in a study of 73 subjects (34M; 39F) with genetically confirmed PWS in 32 individuals previously diagnosed with moderate to severe scoliosis (mean age=16...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29208357/differential-expression-of-igfbps-in-laron-syndrome-derived-lymphoblastoid-cell-lines-potential-correlation-with-reduced-cancer-incidence
#17
Lina Somri, Rive Sarfstein, Lena Lapkina-Gendler, Karthik Nagaraj, Zvi Laron, Leon A Bach, Haim Werner
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, is a growth disorder that results from mutation of the GH-receptor (GHR) gene leading to congenital insulin-like growth factor-1 (IGF-1) deficiency. Recent epidemiological studies have shown that LS patients are protected from cancer development. Genome-wide profiling identified genes and signaling pathways that are differentially represented in LS patients, and that may contribute to cancer protection. The present study was aimed at evaluating the hypothesis that IGF binding proteins (IGFBPs) are differentially expressed in LS, most probably as a result of low circulating levels of IGF-1...
April 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29459140/corrigendum-to-assessment-of-quality-of-life-on-4-year-growth-hormone-therapy-in-japanese-patients-with-adult-growth-hormone-deficiency-a-post-marketing-multicenter-observational-study-growth-hormon-igf-res-36-2017-36-43
#18
Hitoshi Ishii, Akira Shimatsu, Hiromi Nishinaga, Osamu Murai, Kazuo Chihara
No abstract text is available yet for this article.
February 16, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29459141/a-descriptive-study-on-selected-growth-parameters-and-growth-hormone-receptor-gene-in-healthy-young-adults-from-the-american-midwest
#19
Samantha N Hartin, Waheeda A Hossain, Ann M Manzardo, Shaquanna Brown, Paula J Fite, Marco Bortolato, Merlin G Butler
CONTEXT: The first study of growth hormone receptor (GHR) genotypes in healthy young adults in the United States attending a Midwestern university and impact on selected growth parameters. OBJECTIVE: To describe the frequency of GHR genotypes in a sample of healthy young adults from the United States attending a university in the Midwest and analyze the relationship between GHR genotypes and selected growth parameters. DESIGN: Saliva was collected from 459 healthy young adults (237 females, 222 males; age range = 18-25 y) and DNA isolated for genotyping of GHR alleles (fl/fl, fl/d3, or d3/d3)...
February 12, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452886/shifting-the-igf-axis-an-age-related-decline-in-human-tear-igf-1-correlates-with-clinical-signs-of-dry-eye
#20
Roshni Patel, Meifang Zhu, Danielle M Robertson
OBJECTIVE: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1. DESIGN: Tear levels of IGF-1 were measured in 41 healthy, human volunteers without any reported symptoms of dry eye...
February 6, 2018: Growth Hormone & IGF Research
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