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Brazilian Journal of Infectious Diseases

Xuehan Li, Fang Fang, Jin Zhao, Ning Lou, Chenglin Li, Tao Huang, Yirong Li
BACKGROUND: The rate of methicillin-resistant Staphylococcus aureus (MRSA) among the total of S. aureus isolated decreased to 35.3% in 2017 in China. It is unclear whether the molecular characteristics of S. aureus isolates have changed as the rate decreased. OBJECTIVE: This study aimed to investigate the molecular characteristics and virulence genes profile of S. aureus isolates causing bloodstream infection and analyze the correlation between the prevalence rates of the common ST types and MRSA...
December 27, 2018: Brazilian Journal of Infectious Diseases
Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of clinically resistant HBV strains is imperative, and new antiviral drugs are needed urgently to prevent selection of drug-resistant HBV mutants. A novel fluorinated cytidine analog, NCC (N-cyclopropyl-4'-azido-2'-deoxy-2'-fluoro-β-d-cytidine), was recently shown to strongly inhibit human HBV in vitro and in vivo...
December 23, 2018: Brazilian Journal of Infectious Diseases
Natanael Sutikno Adiwardana, Juliana de Angelo Morás, Leandro Lombo Bernardo, Giselle Burlamaqui Klautau, Wladimir Queiroz, Jose Ernesto Vidal
No abstract text is available yet for this article.
December 6, 2018: Brazilian Journal of Infectious Diseases
Jiazhen Chen, Qiaoling Ruan, Yaojie Shen, Sen Wang, Lingyun Shao, Wenhong Zhang
The Region of D eletion 2 (RD2) of Mycobacterium tuberculosis encodes reserved antigens that contribute to bacterial virulence. Among these antigens, Rv1983, Rv1986, Rv1987, and Rv1989c have been shown to be immunodominant in infected cattle; however, their diagnostic utility has not been evaluated in humans. In this study, we screened 87 overlapping synthetic peptides encoded by five RD2 proteins for diagnosing tuberculosis epitopes in 50 active tuberculosis (TB) cases, 31 non-tuberculosis patients and 36 healthy individuals...
December 5, 2018: Brazilian Journal of Infectious Diseases
Lisie Souza Castro, Grazielli Rocha de Rezende, Fernanda Rodas Pires Fernandes, Larissa Melo Bandeira, Marco Antonio Moreira Puga, Tayana Serpa Ortiz Tanaka, Sabrina Moreira Dos Santos Weis, Ana Carolina Paulo Vicente, Koko Otsuki, Ana Rita Coimbra Motta-Castro
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus discovered in humans and is endemic in several parts of the world. Because of risk behaviors, mainly sexual, men who have sex with men (MSM) are at high risk of acquiring HTLV-1 infection. A cross-sectional study was performed to estimate the prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) infection, to characterize genetically HTLV-1 sequences and to identify risk behaviors associated with this infection among MSM in Central Brazil...
December 5, 2018: Brazilian Journal of Infectious Diseases
Carlos E Reu, Waldemar Volanski, Karoline C Prediger, Geraldo Picheth, Cyntia M T Fadel-Picheth
No abstract text is available yet for this article.
December 5, 2018: Brazilian Journal of Infectious Diseases
Fernanda Wirth, Maria Isabel Azevedo, Luciano Z Goldani
There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in predominantly HIV-infected patients with meningoencephalitis admitted to a tertiary care hospital in the southern area of Brazil...
November 30, 2018: Brazilian Journal of Infectious Diseases
Rachel Gimenes Albuquerque, Jane Tomimori, Lucile Maria Floeter-Winter, Sergio Tufik, Monica Levy Andersen
No abstract text is available yet for this article.
November 27, 2018: Brazilian Journal of Infectious Diseases
Michele Berger Ferreira, Fernanda de-Paris, Rodrigo Minuto Paiva, Luciana de Souza Nunesa
Group B Streptococcus (GBS) is a causative agent of invasive neonatal infections. Maternal colonization by GBS is a necessary condition for vertical transmission, with efficient screening of pregnant women playing an essential role in the prevention of neonatal infections. In this study, we aimed to compare the performance of conventional polymerase chain reaction (PCR) and real-time PCR (qPCR) assays as screening methods for GBS in pregnant women against the microbiological culture method considered as the gold-standard...
November 21, 2018: Brazilian Journal of Infectious Diseases
Marcio Nucci, Paula Rocha Braga, Simone A Nouér, Elias Anaissie
BACKGROUND: The impact of central venous catheter (CVC) removal on the outcome of patients with candidemia is controversial, with studies reporting discrepant results depending on the time of CVC removal (early or any time during the course of candidemia). OBJECTIVE: Evaluate the effect of time to CVC removal, early (within 48h from the diagnosis of candidemia) vs. removal at any time during the course of candidemia, on the 30-day mortality. METHODS: Retrospective cohort study of 285 patients with candidemia analyzing CVC removal within 48h (first analysis) or at any time (second analysis)...
November 20, 2018: Brazilian Journal of Infectious Diseases
D E Corzo-León, D Perales-Martínez, A Martin-Onraet, N Rivera-Martínez, A Camacho-Ortiz, H Villanueva-Lozano
BACKGROUND: Invasive fungal infections (IFIs) affect >1.5 million people per year. Nevertheless, IFIs are usually neglected and underdiagnosed. IFIs should be considered as a public-health problem and major actions should be taken to tackle them and their associated costs. Aim To report the incidence of IFIs in four Mexican hospitals, to describe the economic cost associated with IFIs therapy and the impact of adverse events such as acute kidney injury (AKI), liver damage (LD), and ICU stay...
November 2, 2018: Brazilian Journal of Infectious Diseases
Anca Drăgănescu, Oana Săndulescu, Dragoş Florea, Ovidiu Vlaicu, Anca Streinu-Cercel, Dan Oţelea, Victoria Aramă, Monica Luminiţa Luminos, Adrian Streinu-Cercel, Maria Niţescu, Alina Ivanciuc, Rodica Bacruban, Daniela Piţigoi
BACKGROUND: Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage. OBJECTIVES: To describe the influenza cases and viral circulation among hospitalized patients. METHODS: A prospective study based on active surveillance of inpatients with influenza-like illness from a tertiary hospital in Bucharest, Romania, in the season 2016/17. RESULTS: A total of 446 patients were tested, with a balanced gender distribution...
October 31, 2018: Brazilian Journal of Infectious Diseases
Alexandre Malek, Sara Isabel Gomez-Villegas, Alejandro de la Hoz, Cima Nowbakht, Cesar A Arias
A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72h later. The diagnosis of influenza vaccine-related Henoch-Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization.
October 30, 2018: Brazilian Journal of Infectious Diseases
Fernanda H Maruyama, Thais O Morgado, Richard C Pacheco, Luciano Nakazato, Valeria Dutra
No abstract text is available yet for this article.
October 30, 2018: Brazilian Journal of Infectious Diseases
Rolando Paternina-de la Ossa, Seila Israel do Prado, Maria Célia Cervi, Denissani Aparecida Ferrari Dos Santos Lima, Roberto Martinez, Fernando Bellissimo-Rodrigues
BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is spreading worldwide, but little is known about the epidemiology of this pathogen in Brazil. OBJECTIVE: To evaluate clinical and microbiological features of children with S. aureus infections admitted to a university hospital. METHODS: This was a cross-sectional study evaluating the potential risk factors for CA-MRSA, and a retrospective cohort evaluating in-hospital clinical outcomes...
October 30, 2018: Brazilian Journal of Infectious Diseases
Karla Maria Tamez-Torres, Pedro Torres-Gonzalez, Miguel E Cervera-Hernandez, Barbara Chavez-Mazari, Corazon de Jesus Barrientos-Flores, Miriam Bobadilla-Del-Valle, Alfredo Ponce-de-Leon, Jose Sifuentes-Osornio
OBJECTIVES: To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture. METHODS: Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015. RESULTS: We reviewed medical records of 533 patients with culture-proven tuberculosis, of whom 27.2% (145/533) had blood culture available. Patients with mycobacteremia presented more frequently with abdominal tuberculosis, body mass index <18kg/m2 , and had lower hemoglobin and albumin levels...
October 30, 2018: Brazilian Journal of Infectious Diseases
Antonio V C Coelho, Ronald R de Moura, Rafael L Guimarães, Lucas A C Brandão, Sergio Crovella
OBJECTIVE: Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving viral suppression. The genetic component of this condition is not yet completely elucidated. OBJECTIVE: To identify predictive genetic markers of immune response to ART. METHODS: Case-control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls...
October 27, 2018: Brazilian Journal of Infectious Diseases
Luciana Nascimento Pinto Canela, Maria Clara de Magalhães-Barbosa, Carlos Eduardo Raymundo, Sharon Carney, Marilda Mendonca Siqueira, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha
OBJECTIVES: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic. METHOD: Longitudinal observational retrospective study, with patients aged 0-18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009...
October 23, 2018: Brazilian Journal of Infectious Diseases
Per Lundberg, Rune Andersson, Elizabeth S Machado, Tomaz Pinheiro da Costa, Cristina Barroso Hofer
BACKGROUND: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women. AIM: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil. METHODS: A cohort study...
October 16, 2018: Brazilian Journal of Infectious Diseases
Igor Vasconcelos Rocha, Danilo Elias Xavier, Karoline Rissele Henrique de Almeida, Sibele Ribeiro de Oliveira, Nilma Cintra Leal
Acinetobacter baumannii is one of the most frequent Gram-negative opportunistic pathogens associated with hospital-acquired infection worldwide. We briefly describe A. baumannii isolates that were recovered from surrounding ICU bed surfaces, exhibiting multidrug resistance phenotype and belonging to some widely spread clonal complexes of clinical A. baumannii isolates.
September 25, 2018: Brazilian Journal of Infectious Diseases
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