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Brazilian Journal of Infectious Diseases

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https://www.readbyqxmd.com/read/29035701/does-sofa-predict-outcomes-better-than-sirs-in-brazilian-icu-patients-with-suspected-infection-a-retrospective-cohort-study
#1
Regis Goulart Rosa, Rafael Barberena Moraes, Thiago Costa Lisboa, Daniel Pretto Schunemann, Cassiano Teixeira
We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation (MV), ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points)...
October 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#2
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 11, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968510/molecular-diagnosis-of-symptomatic-toxoplasmosis-a-9-year-retrospective-and-prospective-study-in-a-referral-laboratory-in-s%C3%A3-o-paulo-brazil
#3
Lilian Muniz Camilo, Vera Lucia Pereira-Chioccola, Ricardo Gava, Cristina da Silva Meira-Strejevitch, Jose Ernesto Vidal, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Luiz Carlos de Mattos, Lígia Cosentino Junqueira Franco Spegiorin
Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10-20% of the infected people. Aiming to improve the molecular diagnosis of symptomatic toxoplasmosis in Brazilian patients, this study evaluated the performance of real time PCR (qPCR) testing two primer sets (B1 and REP-529) in detecting Toxoplasma gondii DNA. The methodology was assayed in 807 clinical samples with known clinical diagnosis, ELISA, and conventional PCR (cPCR) results in a 9-year period. All samples were from patients with clinical suspicion of several features of toxoplasmosis...
September 29, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28964777/long-term-virologic-and-immunologic-responses-on-darunavir-ritonavir-containing-regimens-among-highly-art-experienced-patients-7-year-follow-up-of-a-prospective-cohort-study-in-s%C3%A3-o-paulo-brazil
#4
LETTER
José E Vidal, Ariane M R Dos Santos, Érique J Peixoto de Miranda, Aluísio C Segurado
No abstract text is available yet for this article.
September 28, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28950107/comparison-between-the-gold-standard-dxa-with-calcaneal-quantitative-ultrasound-based-strategy-qus-to-detect-osteoporosis-in-an-hiv-infected-cohort
#5
Eugenia Quiros Roldan, Nigritella Brianese, Elena Raffetti, Emanuele Focà, Maria Chiara Pezzoli, Andrea Bonito, Alice Ferraresi, Paola Lanza, Teresa Porcelli, Francesco Castelli
INTRODUCTION: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture. METHODS: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound...
September 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941395/malaria-in-southern-brazil-a-potential-threat-for-a-non-endemic-region
#6
LETTER
Daisson L Moreira, Jader C Cardoso, Sandra C Deboni, Diego R Falci
No abstract text is available yet for this article.
September 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941394/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-healthcare-associated-infections-in-latin-america-report-from-an-antimicrobial-surveillance-program-2013-2015
#7
Michael A Pfaller, Dee Shortridge, Helio S Sader, Ana Gales, Mariana Castanheira, Robert K Flamm
This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries...
September 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941393/mobile-health-application-to-assist-doctors-in-antibiotic-prescription-an-approach-for-antibiotic-stewardship
#8
Felipe Francisco Tuon, Juliano Gasparetto, Luciana Cristina Wollmann, Thyago Proença de Moraes
BACKGROUND: Technologies applied to mobile devices can be an important strategy in antibiotic stewardship programs. OBJECTIVE: The aim of this study was to determine the impact of a decision-making application on antibiotic prescription. METHODS: This was an observational, analytical and longitudinal study on the implementation of an antimicrobial guide for mobile application (app). This study analyzed the period of 12 months before and 12 months after the app implementation at a university hospital based on local epidemiology, avoiding high cost drugs and reducing the potential for drug resistance including carbapenem...
September 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28923505/subcutaneous-infection-by-graphium-basitruncatum-in-a-heart-transplant-patient
#9
Analía L Fernández, Patricia O Andres, Cecilia H Veciño, Claudia B Nagel, María Teresa Mujica
Graphium basitruncatum, a synanamorph of Pseudoallescheria has been rarely reported in human infections. We report a case of subcutaneous phaeohyphomycosis caused by this fungus in a heart transplant recipient. We also describe the phenotypic, molecular methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) used to achieve isolate identification.
September 15, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28759747/clonal-dissemination-of-vancomycin-resistant-enterococcus-faecium-st412-in-a-brazilian-region
#10
Geraldo da Silva Alves, Monalessa Fábia Pereira, Lais de Lima Bride, Ana Paula Ferreira Nunes, Ricardo Pinto Schuenck
Vancomycin-resistant Enterococcus faecium (VREfm) has emerged as an important global nosocomial pathogen, and this trend is associated with the spread of high-risk clones. Here, we determined the genetic and phenotypic features of 93 VREfm isolates that were obtained from patients in 13 hospitals in Vitória, Espírito Santo, Brazil, during 2012-2013. All the isolates were vancomycin-resistant and harbored the vanA gene. Only 6 (6.5%) of the VREfm isolates showed the ability to form biofilm. The 93 isolates analyzed belong to a single pulsed-field gel electrophoresis lineage and presented six subtypes...
July 28, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28759746/serum-markers-as-an-aid-in-the-diagnosis-of-pulmonary-fungal-infections-in-aids-patients
#11
Ana Isabela Passos, Rachel Polo Dertkigil, Marcelo de Carvalho Ramos, Ariane BussoLopes, Cibele Tararan, Erivan Olinda Ribeiro, Angélica Zaninelli Schreiber, Plinio Trabasso, Mariangela Ribeiro Resende, Maria Luiza Moretti
INTRODUCTION: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy. MATERIALS AND METHODS: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-β-D-Glugan (BG), galactomannan, and lactate dehydrogenase (LDH)...
July 28, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28688628/will-mayaro-virus-be-responsible-for-the-next-outbreak-of-an-arthropod-borne-virus-in-brazil
#12
REVIEW
Danillo Lucas Alves Esposito, Benedito Antonio Lopes da Fonseca
Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade fever, maculopapular skin rash and marked arthralgia that, in some patients, can persist for long periods after infection and may be misinterpreted as chikungunya. Although only a few outbreaks involving this virus have been reported, in the last years the number of Mayaro virus infections has increased in the central and northern regions of Brazil...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28648813/rapid-spread-of-an-ongoing-outbreak-of-zika-virus-disease-in-pregnant-women-in-a-mexican-hospital
#13
Elvira Garza-González, Soraya Mendoza-Olazarán, Raúl Roman-Campos, Ricardo Téllez-Marroquín, Donato Saldívar-Rodríguez, Juan A Soria-López, Abel Guzman, Samantha Flores-Treviño, Adrián Camacho-Ortiz
In the first nine weeks of implementation of a Zika Virus Preparedness Plan in a Mexican Public Hospital, we cared for 221 pregnant women with any signal or symptom suggesting Zika virus infection and 99 (44.8%) patients were found to be positive for Zika virus. The median age of patients was 25.3 years (range 13-49). Symptoms in PCR-positive patients were rash (91.4%) followed by headache (53.1%), myalgia (46.9%), arthralgia (45.7%), pruritus (35.8%), retroocular pain (29.6%), conjunctivitis (21%), and fever (21%)...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28641091/increasing-rates-of-clostridium-difficile-infection-in-mexican-hospitals
#14
Laura Palau Dávila, Elvira Garza-González, Patricia Rodríguez-Zulueta, Rayo Morfín-Otero, Eduardo Rodríguez-Noriega, Diana Villar-Compte, Juan C Rodríguez-Aldama, Adrián Camacho-Ortiz
INTRODUCTION: The epidemiology of Clostridium difficile infection (CDI) has changed in the last two decades. There is a lack of information regarding incidence and severity of CDI, especially in the developing world. METHODS: This was a retrospective and observational study from four hospitals of three Mexican cities. Patients were diagnosed with CDI when presented with loose stools and had at least one of the following tests positive: toxins assay, real-time PCR, or an endoscopic image compatible with pseudomembranous colitis...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28628760/tuberculosis-incidence-among-people-living-with-hiv-aids-with-virological-failure-of-antiretroviral-therapy-in-salvador-bahia-brazil
#15
Monaliza Cardozo Rebouças, Márcio Oliveira da Silva, Tatiana Haguihara, Carlos Brites, Eduardo Martins Netto
Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS. Tuberculosis has been shown to be a good predictor of virological failure in this group. This study aimed to evaluate the incidence of tuberculosis and its consequences among individuals diagnosed with virological failure of HIV. This was a retrospective cohort study involving people living with HIV/AIDS being followed-up in an AIDS reference center in Salvador, Bahia, Brazil...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28623676/unrecognized-pediatric-and-adult-family-members-of-children-with-acute-brucellosis
#16
Dilek Yılmaz Çiftdoğan, Selda Aslan
BACKGROUND AND AIM: Brucellosis is an infectious, contagious and zoonotic disease that occurs worldwide. The family members of an index case of brucellosis may be especially susceptible, due to sharing the same source of infection and similar risk factors for brucellosis. In this study, we propose to screen pediatric and adult family members of brucellosis index cases for detecting additional unrecognized infected family members. MATERIALS AND METHODS: 114 family members of 41 pediatric patients with brucellosis were evaluated...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28623675/development-of-a-prototype-immunochromatographic-test-for-rapid-diagnosis-of-respiratory-adenovirus-infection
#17
Inarei Paulini, Joselma Siqueira-Silva, Luciana Thomaz, Leticia Rocha, Charlotte Harsi, Nancy Bellei, Celso Granato
Human adenoviruses comprise an important group of etiologic agents that are responsible for various diseases in adults and children, such as respiratory, ocular, gastroenteric, and urinary infections. In immunocompromised and organ-transplanted individuals, these agents can cause generalized infections. Rapid diagnostic methods for detecting these infectious agents are not widely available. The aim of this work was to produce monoclonal and polyclonal anti-adenovirus antibodies to be used in a rapid diagnostic test for respiratory infections...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28609647/a-case-of-chronic-lacrimal-canaliculitis-revisiting-the-role-of-actinomyces-israelii
#18
LETTER
Srujana Mohanty, Subhrajyoti Sahu, Sucheta Parija, Ashok K Praharaj
No abstract text is available yet for this article.
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28606416/intrauterine-fetal-death-due-to-congenital-cytomegalovirus-infection
#19
Stefano Licci
No abstract text is available yet for this article.
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28606415/identification-of-hepatitis-b-virus-a1762t-g1764a-double-mutant-strain-in-patients-in-southern-brazil
#20
Adaliany Cecília da Silva Souza, Giórgia de Souza Marasca, Nélson Alexandre Kretzmann-Filho, Aline Dall-Bello, Dimas Alexandre Kliemann, Cristiane Valle Tovo, Ana Beatriz Gorini da Veiga
Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing cirrhosis and/or hepatocellular carcinoma. This study analyzed the presence of the HBV A1762T/G1764A double mutant in patients with chronic HBV and its association with clinical parameters such as viral load, aminotransferases, and HBV antigens...
September 2017: Brazilian Journal of Infectious Diseases
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