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Brazilian Journal of Infectious Diseases

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https://www.readbyqxmd.com/read/28435012/il-10-down-regulates-the-expression-of-survival-associated-gene-hspx-of-mycobacterium-tuberculosis-in-murine-macrophage
#1
Babban Jee, Pawan Sharma, Kiran Katoch, Beenu Joshi, Sudhir Kumar Awasthi
Mycobacterium tuberculosis (MTB) adopts a special survival strategy to overcome the killing mechanism(s) of host immune system. Amongst the many known factors, small heat shock protein 16.3 (sHSP16.3) of MTB encoded by gene hspX has been reported to be critical for the survival of MTB. In the present study, the effect of recombinant murine interferon-gamma (rmIFN-γ) and recombinant murine interleukin-10 (rmIL-10) on the expression of gene hspX of MTB in murine macrophage RAW264.7 has been investigated. By real-time RT-PCR, it was observed that three increasing concentrations (5, 25 and 50ng/ml) of rmIFN-γ significantly up-regulated the expression of hspX whereas similar concentrations of rmIL-10 (5, 25 and 50ng/ml) significantly down-regulated the hspX expression...
April 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28435011/the-in-vitro-activity-of-ceftazidime-avibactam-against-417-gram-negative-bacilli-collected-in-2014-and-2015-at-a-teaching-hospital-in-s%C3%A3-o-paulo-brazil
#2
LETTER
Flávia Rossi, Ana P Cury, Maria R G Franco, Raymond Testa, Wright W Nichols
No abstract text is available yet for this article.
April 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28432878/in-vitro-susceptibility-of-methicillin-resistant-staphylococcus-aureus-isolates-from-skin-and-soft-tissue-infections-to-vancomycin-daptomycin-linezolid-and-tedizolid
#3
Johanna Marcela Vanegas Múnera, Ana María Ocampo Ríos, Daniela Montoya Urrego, Judy Natalia Jiménez Quiceno
INTRODUCTION: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid, and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections. MATERIAL AND METHODS: Methicillin-resistant S...
April 19, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28399426/hpv-related-external-genital-lesions-among-men-residing-in-brazil
#4
Roberto J C Silva, Staci L Sudenga, Laura Sichero, Maria Luiza Baggio, Lenice Galan, Ricardo Cintra, B Nelson Torres, Mark Stoler, Anna R Giuliano, Luisa L Villa
The aims of this study were to determine the incidence of external genital lesions (EGLs), specifically histologically confirmed condyloma (genital warts) and Penile Intraepithelial Neoplasia (PeIN), and genital HPV infection progression to EGLs among healthy men aged 18-73 residing in Brazil. Subjects included 1118 men enrolled in the HPV Infection in Men (HIM) study between July 2005 and June 2009. At each visit, EGLs were biopsied and subjected to pathological evaluation. HPV status in genital swabs and biopsies was determined by Linear Array and INNO-LiPA, respectively...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28399425/direct-identification-from-positive-blood-broth-culture-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#5
Maria Goreth Barberino, Marcio Silva Oliveira, Ana Carolina Palmeiras Arraes, Luís Cláudio Correia, Ana Verena Mendes
Bloodstream infections (BSIs) are among the most concerning bacterial infections. They are one of the leading causes of morbidity and mortality, and occur in 30-70% of critical care patients. The prompt identification of the causative microorganism can help choosing the appropriate antimicrobial therapy that will lead to better clinical outcomes. Blood culture is one of the most relevant tests for microbiological diagnosis of bacterial infections. The introduction of the MALDI-TOF microbiological diagnosis significantly decreased the time of identifying microorganisms...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28399424/resistance-among-gram-negative-eskape-pathogens-isolated-from-hospitalized-patients-with-intra-abdominal-and-urinary-tract-infections-in-latin-american-countries-smart-2013-2015
#6
James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. Gram-negative ESKAPE pathogens were collected from hospitalized patients in 11 Latin American countries from 2013 to 2015 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program. In total, 2113 isolates from intra-abdominal infections (IAI) and 970 isolates from urinary tract infections (UTI) were tested against antimicrobial agents using standardized CLSI broth microdilution methodology...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28399423/bone-mineral-density-and-vitamin-d-concentration-the-challenges-in-taking-care-of-children-and-adolescents-infected-with-hiv
#7
Fabiana Bononi Carmo, Maria Teresa Terreri, Regina Célia de Menezes Succi, Suenia Vasconcelos Beltrão, Aida de Fátima Tomé Barbosa Gouvea, Erica Regina Cruz Paulino, Daisy Maria Machado
The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. OBJECTIVES: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. METHODS: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28376315/safety-and-efficacy-of-a-novel-drug-elores-ceftriaxone-sulbactam-disodium-edetate-in-the-management-of-multi-drug-resistant-bacterial-infections-in-tertiary-care-centers-a-post-marketing-surveillance-study
#8
Manu Chaudhary, Mohd Amin Mir, Shiekh Gazalla Ayub
OBJECTIVE: In India, elores (CSE-1034: ceftriaxone+sulbactam+disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of ESBL/MBL infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with ESBL/MBL infections and identify the incidence of adverse events in real clinical settings. METHODS: This PMS study was conducted at 17 centers across India and included 2500 patients of all age groups suffering from various bacterial infections and treated with CSE-1034...
April 1, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28365193/danger-in-the-streets-exposures-to-bloodborne-pathogens-after-community-sharp-injuries-in-rio-de-janeiro-brazil
#9
Marcellus Dias Costa, Cristiane Rapparini, Carolina Arana Stanis Schmaltz, Mari Tuyama, Lilian de Mello Lauria, Valeria Saraceni, Paulo Feijó Barroso
OBJECTIVE: Exposures to sharps injuries occurring in the community are relatively frequent. We describe characteristics of community sharp exposures reported in the city of Rio de Janeiro from 1997 to 2010. METHODS: A cross-sectional analysis of exposure reports to sharps in the community reported to a surveillance system, designed for health care workers, of the Municipal Health Department of Rio de Janeiro. The characteristics of exposed individuals analyzed included types of exposure, the circumstances of the accident, and the prophylaxis offered...
March 29, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28363087/geolocalization-of-hiv-1-subtypes-and-resistance-mutations-of-patients-failing-antiretroviral-therapy-in-salvador-brazil
#10
Antonio Walter de Oliveira Filho, Carlos Brites
BACKGROUND: Geographical distribution of HIV variants is an important way to understand the circulation and spread of such viral strains. OBJECTIVES: To evaluate the spatial distribution of HIV-1 variants in patients failing antiretroviral therapy, in Salvador, Brazil. METHODS: We performed a cross-sectional evaluation of HIV resistance test reports of patients who underwent genotyping tests in a referral center in Salvador, Brazil, for the years 2008-2014...
March 28, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28351603/predictors-of-hbeag-seroconversion-after-long-term-nucleos-t-ide-analogues-treatment-for-chronic-hepatitis-b-a-multicenter-study-in-real-clinical-setting
#11
Weiyan Yu, Yadong Wang, Chuan Shen, Ru Ji, Li Zhang, Xin Zhao, Miao Su, Yin Zhang, Wenyan He, Jianguo Cao, Yanshuang Hao, Shengpeng Chen, Caiyan Zhao
AIMS: To evaluate the HBeAg seroconversion rate in real clinical setting and explore its predictors in long-term nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B (CHB). METHODS: 251 patients were recruited from January 2001 to September 2009 in four hospitals in HeBei province, China, for this retrospective study. Clinical and laboratory data before and after treatment with lamivudine (LAM, 100mg daily), adefovir (ADV, 10mg daily), telbivudine (LDT, 600mg daily), ETV (0...
March 25, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28347732/association-between-the-p53-arginine-arginine-homozygous-genotype-at-codon-72-and-human-papillomavirus-e6-e7-mrna-expression
#12
Ana Carolina Silva Chuery, Ismael Dale Cotrim Guerreiro da Silva, Julisa Chamorro Lascasas Ribalta, Neila Maria de Góis Speck
OBJECTIVE: To evaluate the association between p53 polymorphisms and human papillomavirus (HPV) E6/E7 mRNA expression. METHODS: We analyzed 175 cervical samples from women aged 16-69 years old who were tested for HPV E6/E7 mRNA expression (NucliSENS(®) EasyQ(®) HPV). The samples were divided into three groups: positive (n=75) those with positive HPV E6/E7 mRNA expression and positive high-risk HPV Hybrid Capture (HR-HC) test; negative (n=52) those with negative HPV E6/E7 mRNA expression and positive HR-HC; and control (n=48) those with negative HPV E6/E7 mRNA expression and negative HR-HC...
March 24, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28343818/comparative-performances-of-serologic-and-molecular-assays-for-detecting-human-t-lymphotropic-virus-type-1-and-type-2-htlv-1-and-htlv-2-in-patients-infected-with-human-immunodeficiency-virus-type-1-hiv-1
#13
Karoline Rodrigues Campos, Maria Gisele Gonçalves, Nadia Aparecida Costa, Adele Caterino-de-Araujo
The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n=1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n=1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for human T lymphotropic viruses types 1 and 2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection...
March 24, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28343819/meropenem-induced-low-valproate-levels-in-a-cerebral-palsy-child
#14
LETTER
Lucas Miyake Okumura, Cinara Andreolio, Carla Di Giorgio, Paulo Roberto Antonacci Carvalho, Jefferson Pedro Piva
No abstract text is available yet for this article.
March 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28286017/tungiasis-in-a-colombian-patient
#15
Claudia J Díaz, Kevin Escandón-Vargas
No abstract text is available yet for this article.
March 10, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28286016/fluconazole-prophylaxis-in-preterm-infants-a-systematic-review
#16
REVIEW
Juliana Ferreira da Silva Rios, Paulo Augusto Moreira Camargos, Luísa Petri Corrêa, Roberta Maia de Castro Romanelli
OBJECTIVE: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis. METHODS: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants". RESULTS: Invasive Candidiasis was evaluated in all the twelve items...
March 9, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28284657/prevalence-and-risk-factors-for-human-papillomavirus-infection-among-chinese-ethnic-women-in-southern-of-yunnan-china
#17
Zulqarnain Baloch, Nafeesa Yasmeen, Li Yuanyue, Ke Ma, Xiaomei Wu, Yang Shihua, Xia Xueshan
BACKGROUND: Dai is a major Chinese ethnic minority group residing in rural areas of the southern part of Yunnan. However, no data exist on the HPV prevalence and genotype distribution among Dai women. METHOD: A total of 793 participants (Dai=324, Han=251, other ethnic=218) were included in this study. PCR was performed to detect the HPV-positive samples, and genotyping was performed with an HPV Geno-Array. RESULT: The overall HPV prevalence was very low among Dai women compared to the others...
March 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28284656/metabolic-syndrome-in-hiv-infected-middle-aged-women-on-antiretroviral-therapy-prevalence-and-associated-factors
#18
Lívia D Akl, Ana L R Valadares, Monica Jacques de Moraes, Aarão M Pinto-Neto, Bianca Lagrutta, Lúcia Costa-Paiva
OBJECTIVES: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. METHODS: Cross-sectional study including 273 HIV-infected climacteric women of 40-60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters...
March 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28282509/effects-of-statins-on-the-development-of-sepsis-and-organ-dysfunction-in-hospitalized-older-patients-in-china
#19
Qifeng Gui, Yunmei Yang, Jiajia Zhang
This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission...
March 7, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28282508/cardiovascular-risk-profile-in-patients-with-myelopathy-associated-with-htlv-1
#20
Fabio Luís Silva do Prado, Renata Prado de Fuccio Oliveira, Ana Marice Teixeira Ladeia
HAM/TSP (HTLV-1-associated myelopathy/tropical spastic paraparesis) is a slowly progressive disease, characterized by a chronic spastic paraparesis. It is not known if the disease carries an independent risk for cardiovascular disease. The objective of this study was to evaluate the cardiovascular risk profile related to HAM/TSP and compare it with the general population. METHODS: This was a cross-sectional study, with a control group. HAM/TSP patients were evaluated using cardiovascular risk scores (ASCVD RISK, SCORE and Framingham) and inflammatory markers (ultrasensitive CRP and IL-6), and compared with a control group of healthy individuals...
March 7, 2017: Brazilian Journal of Infectious Diseases
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