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Brazilian Journal of Infectious Diseases

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https://www.readbyqxmd.com/read/29207280/hybrid-capture-as-a-tool-for-cervical-lesions-screening-in-hiv-infected-women-insights-from-a-brazilian-cohort
#1
Emilia Moreira Jalil, Paula M Luz, Marcel Quintana, Ruth Khalili Friedman, Rosa M Domingues S Madeira, Angela Cristina Andrade, Janice Chicarino, Ronaldo Ismerio Moreira, Monica Derrico, José Eduardo Levi, Fabio Russomano, Valdilea Gonçalves Veloso, Beatriz Grinsztejn
INTRODUCTION: Cervical cancer remains an important burden for HIV-infected women in the era of combination antiretroviral therapy. Recommendations for cervical screening in these women diverge and may include high-risk HPV (HRHPV) testing. We aimed to evaluate the clinical usefulness of a single HRHPV testing for cervical screening of HIV-infected women. METHODS: 723 HIV-infected women from a Brazilian prospective cohort were included between 1996 and 2012. Inclusion criteria were: normal cervical cytology at baseline and having a HRHPV-test at baseline...
December 2, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29182906/effect-of-polymyxin-b-containing-regimens-on-renal-function-for-the-treatment-of-carbapenem-resistant-enterobacteriacea-mediastinitis
#2
Cely Saad Abboud, Gauri G Rao, Ercilia E Sousa, Alexandre P Zavascki, Carlos Kiffer
A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p=0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.
November 25, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29172033/in-vitro-antifungal-susceptibility-of-clinical-and-environmental-isolates-of-aspergillus-fumigatus-and-aspergillus-flavus-in-brazil
#3
Laura Bedin Denardi, Bianca Hoch Dalla-Lana, Francielli Pantella Kunz de Jesus, Cecília Bittencourt Severo, Janio Morais Santurio, Régis Adriel Zanette, Sydney Hartz Alves
The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2...
November 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29172032/galactomannan-use-in-clinical-practice-providing-free-testing-is-not-the-answer
#4
Jeniffer S Dos Santos, Djuli M Hermes, Alessandro C Pasqualotto
INTRODUCTION: Invasive aspergillosis (IA) is a condition associated with a high mortality rate due to difficulties in performing an early diagnosis. In recent years, galactomannan (GM) detection has markedly improved the diagnosis of IA, but very little is known on how physicians deal with this test in clinical practice. METHODS: This cross-sectional study aimed to analyze the indications for the use of serum GM in a large Brazilian hospital, between 2015 and 2016...
November 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29169012/methicillin-resistant-staphylococcus-aureus-isolated-from-an-intensive-care-unit-in-minas-gerais-brazil-over-a-six-year-period
#5
Thiago C Nascimento, Cláudio G Diniz, Vânia L Silva, Alessandra B Ferreira-Machado, Marina O Fajardo, Tamara Lopes R de Oliveira, Dennis de C Ferreira, Fernanda S Cavalcante, Kátia R Netto Dos Santos
To characterize methicillin-resistant Staphylococcus aureus (MRSA) isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 MRSA isolates were recovered from patients admitted to the ICU in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97.7%), rifampin (88.8%), and gentamycin (86.6%). The SCCmec typing revealed that the isolates harbored the types III (66.7%), II (17...
November 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29144958/isolation-of-blandm-producing-enterobacteriaceae-in-a-public-hospital-in-salvador-bahia-brazil
#6
Maria Goreth Barberino, Silvia de Araujo Cruvinel, Célio Faria, Marco Aurélio Salvino, Márcio Oliveira
Carbapenemases have great importance in the global epidemiological scenario since infections with carbapenemase-producing bacteria are associated with high mortality, especially in hospitalized patients in intensive care units. This study describes two microorganisms producers of the New Delhi Metallo-b-lactamase (NDM), Klebsiella pneumoniae and Citrobacter freundii, from two patients admitted to a public hospital in Salvador, Bahia. These are the first clinical cases of NDM described in microorganisms in the north and northeast Brazil...
November 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29144957/fluconazole-levels-in-serum-and-cerebrospinal-fluid-according-to-daily-dosage-in-patients-with-cryptococcosis-and-other-fungal-infections
#7
Letícia Aparecida Schiave, Erika Nascimento, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Cristiane Masetto de Gaitani, Roberto Martinez
Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid (CSF). In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection criterion was treatment with fluconazole, which was performed with a generic or similar form of the drug. Fluconazole level was determined by high performance liquid chromatography and the susceptibility profile of Cryptococcus spp...
November 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29121486/is-it-time-for-brazil-to-prioritize-tb-preventive-therapy-for-all-people-living-with-hiv
#8
LETTER
Ethel L Maciel, Thiago N do Prado, Kleydson Bonfim Andrade, Jonathan E Golub
No abstract text is available yet for this article.
November 6, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29035701/does-sofa-predict-outcomes-better-than-sirs-in-brazilian-icu-patients-with-suspected-infection-a-retrospective-cohort-study
#9
Regis Goulart Rosa, Rafael Barberena Moraes, Thiago Costa Lisboa, Daniel Pretto Schunemann, Cassiano Teixeira
We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points)...
October 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#10
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 12, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968510/molecular-diagnosis-of-symptomatic-toxoplasmosis-a-9-year-retrospective-and-prospective-study-in-a-referral-laboratory-in-s%C3%A3-o-paulo-brazil
#11
Lilian Muniz Camilo, Vera Lucia Pereira-Chioccola, Ricardo Gava, Cristina da Silva Meira-Strejevitch, Jose Ernesto Vidal, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Luiz Carlos De Mattos, Lígia Cosentino Junqueira Franco Spegiorin
Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10-20% of the infected people. Aiming to improve the molecular diagnosis of symptomatic toxoplasmosis in Brazilian patients, this study evaluated the performance of real time PCR testing two primer sets (B1 and REP-529) in detecting Toxoplasma gondii DNA. The methodology was assayed in 807 clinical samples with known clinical diagnosis, ELISA, and conventional PCR results in a 9-year period. All samples were from patients with clinical suspicion of several features of toxoplasmosis...
September 29, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28964777/long-term-virologic-and-immunologic-responses-on-darunavir-ritonavir-containing-regimens-among-highly-antiretroviral-therapy-experienced-patients-7-year-follow-up-of-a-prospective-cohort-study-in-s%C3%A3-o-paulo-brazil
#12
LETTER
José E Vidal, Ariane M R Dos Santos, Érique J F Peixoto de Miranda, Aluísio C Segurado
No abstract text is available yet for this article.
September 29, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28950107/comparison-between-the-gold-standard-dxa-with-calcaneal-quantitative-ultrasound-based-strategy-qus-to-detect-osteoporosis-in-an-hiv-infected-cohort
#13
Eugenia Quiros Roldan, Nigritella Brianese, Elena Raffetti, Emanuele Focà, Maria Chiara Pezzoli, Andrea Bonito, Alice Ferraresi, Paola Lanza, Teresa Porcelli, Francesco Castelli
INTRODUCTION: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture. METHODS: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound...
September 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941395/malaria-in-southern-brazil-a-potential-threat-for-a-non-endemic-region
#14
LETTER
Daisson L Moreira, Jader C Cardoso, Sandra C Deboni, Diego R Falci
No abstract text is available yet for this article.
September 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941394/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-healthcare-associated-infections-in-latin-america-report-from-an-antimicrobial-surveillance-program-2013-2015
#15
Michael A Pfaller, Dee Shortridge, Helio S Sader, Ana Gales, Mariana Castanheira, Robert K Flamm
This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries...
September 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28941393/mobile-health-application-to-assist-doctors-in-antibiotic-prescription-an-approach-for-antibiotic-stewardship
#16
Felipe Francisco Tuon, Juliano Gasparetto, Luciana Cristina Wollmann, Thyago Proença de Moraes
BACKGROUND: Technologies applied to mobile devices can be an important strategy in antibiotic stewardship programs. OBJECTIVE: The aim of this study was to determine the impact of a decision-making application on antibiotic prescription. METHODS: This was an observational, analytical and longitudinal study on the implementation of an antimicrobial guide for mobile application. This study analyzed the period of 12 months before and 12 months after the app implementation at a university hospital based on local epidemiology, avoiding high cost drugs and reducing the potential for drug resistance including carbapenem...
September 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28923505/subcutaneous-infection-by-graphium-basitruncatum-in-a-heart-transplant-patient
#17
Analía L Fernández, Patricia O Andres, Cecilia H Veciño, Claudia B Nagel, María Teresa Mujica
Graphium basitruncatum, a synanamorph of Pseudoallescheria has been rarely reported in human infections. We report a case of subcutaneous phaeohyphomycosis caused by this fungus in a heart transplant recipient. We also describe the phenotypic, molecular methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) used to achieve isolate identification.
September 18, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28711455/recommendations-for-outpatient-parenteral-antimicrobial-therapy-in-brazil
#18
REVIEW
Priscila R Oliveira, Vladimir C Carvalho, Sergio Cimerman, Ana Lucia Munhoz Lima
A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to determine the recommendations for outpatient parenteral antimicrobial therapy (OPAT) in Brazil. The following aspects are covered in the document: organization of OPAT programs; patient evaluation and eligibility criteria, including clinical and sociocultural factors; diagnosis of eligibility; venous access and antimicrobial infusion devices; protocols for antimicrobial use and monitoring and cost-effectiveness...
November 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28688628/will-mayaro-virus-be-responsible-for-the-next-outbreak-of-an-arthropod-borne-virus-in-brazil
#19
REVIEW
Danillo Lucas Alves Esposito, Benedito Antonio Lopes da Fonseca
Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade fever, maculopapular skin rash and marked arthralgia that, in some patients, can persist for long periods after infection and may be misinterpreted as chikungunya. Although only a few outbreaks involving this virus have been reported, in the last years the number of Mayaro virus infections has increased in the central and northern regions of Brazil...
September 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28648813/rapid-spread-of-an-ongoing-outbreak-of-zika-virus-disease-in-pregnant-women-in-a-mexican-hospital
#20
Elvira Garza-González, Soraya Mendoza-Olazarán, Raúl Roman-Campos, Ricardo Téllez-Marroquín, Donato Saldívar-Rodríguez, Juan A Soria-López, Abel Guzman, Samantha Flores-Treviño, Adrián Camacho-Ortiz
In the first nine weeks of implementation of a Zika Virus Preparedness Plan in a Mexican Public Hospital, we cared for 221 pregnant women with any signal or symptom suggesting Zika virus infection and 99 (44.8%) patients were found to be positive for Zika virus. The median age of patients was 25.3 years (range 13-49). Symptoms in PCR-positive patients were rash (91.4%) followed by headache (53.1%), myalgia (46.9%), arthralgia (45.7%), pruritus (35.8%), retroocular pain (29.6%), conjunctivitis (21%), and fever (21%)...
September 2017: Brazilian Journal of Infectious Diseases
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