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Brazilian Journal of Infectious Diseases

Poliana Castro de Resende Bonati, Carlos Martins da Silva
No abstract text is available yet for this article.
October 13, 2016: Brazilian Journal of Infectious Diseases
Thaís Felli Kubiça, Laura Bedin Denardi, Maria Isabel Azevedo, Vanessa Oliveira, Luiz Carlos Severo, Janio Morais Santurio, Sydney Hartz Alves
The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of both fluconazole-susceptible and fluconazole-resistant Trichosporon asahii. For these analyses, we used the broth microdilution method based on the M27-A3 technique and checkerboard microdilution method. Tacrolimus showed no activity against T...
September 30, 2016: Brazilian Journal of Infectious Diseases
Cahue Henrique Pinto, Helio Tedesco-Silva, C R Felipe, A Ferreira, M Cristelli, L A Viana, W Aguiar, José Medina-Pestana
BACKGROUND: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and the associated costs. This study investigated the efficacy and safety of targeted preemptive therapy according to perceived risk of cytomegalovirus infection after kidney transplantation. METHODS: 144 adult kidney transplant recipients were enrolled in this 12-month study...
September 16, 2016: Brazilian Journal of Infectious Diseases
Jeannete Zurita, Pedro Barba, David Ortega-Paredes, Marcelo Mora, Sebastián Rivadeneira
The spread of pandemic Staphylococcus aureus clones, mainly methicillin-resistant S. aureus (MRSA), must be kept under surveillance to assemble an accurate, local epidemiological analysis. In Ecuador, the prevalence of the USA300 Latin American variant clone (USA300-LV) is well known; however, there is little information about other circulating clones. The aim of this work was to identify the sequence types (ST) using an MLVA 14-locus genotyping approach. We analyzed 132 S. aureus strains that were recovered from 2005 to 2013 and isolated in several clinical settings in Quito, Ecuador...
September 13, 2016: Brazilian Journal of Infectious Diseases
Karolina Akinosoglou, Angelos Alexopoulos, Nikolaos Koutsogiannis, Charalampos Gogos, Aleksandra Lekkou
Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens...
September 12, 2016: Brazilian Journal of Infectious Diseases
Francelli Cordeiro Neves, Wanessa T Clemente, Nilton Lincopan, Isabela D Paião, Patrícia R Neves, Roberta M Romanelli, Stella S S Lima, Luciene F Paiva, Paulo Henrique O Mourão, Vandack A Nobre-Junior
BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important cause of nosocomial infections especially in intensive care units (ICUs). This study aimed to assess clinical aspects and the genetic background of CRAb among ICU patients at a Brazilian teaching hospital. METHODS: 56 critically ill patients colonized or infected by CRAb, during ICU stay, were prospectively assessed. Based on imipenem MIC≥4μg/mL, 28 CRAB strains were screened for the presence of genes encoding metallo-β-lactamases (MβLs) and OXA-type β-lactamases...
September 9, 2016: Brazilian Journal of Infectious Diseases
Houriya Ayoubieh, Eyas Alkhalili
A 37-year-old man with AIDS presented with altered mental status four weeks after stopping his medications for Mycobacterium avium-intracellulare (MAI). He had low CD4 cell count and severe hypercalcemia. Bone marrow biopsy revealed bone marrow infiltration by granulomas positive for acid-fast bacilli and cultures grew MAI. His hypercalcemia continued to worsen with the initiation of MAI therapy but we were able to treat it successfully with pamidronate and calcitonin.
September 9, 2016: Brazilian Journal of Infectious Diseases
Ali Akbar Haji Aghamohammadi, Ali Zargar, Sonia Oveisi, Rasoul Samimi, Sedigheh Reisian
OBJECTIVE: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen. METHODS: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks...
September 7, 2016: Brazilian Journal of Infectious Diseases
Jun Yuan, Yan Zhang, Fu-Tang Yan, Xiao Zheng
OBJECTIVE: Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study. METHODS: We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54...
September 6, 2016: Brazilian Journal of Infectious Diseases
Katie E Barber, Allison M Bell, Samuel Travis King, Jason J Parham, Kayla R Stover
Drug shortages pose a clear detriment to antimicrobial stewardship (AS) efforts. Our objective was to evaluate the effect of a piperacillin-tazobactam shortage on meropenem use, related costs, and associated changes in AS activity. A quasi-experimental quality improvement review compared adult patients receiving meropenem ≥72h three months pre-shortage and three months during the shortage. 320 patients were included (pre-shortage: 103; shortage: 217). Baseline characteristics were similar, but the length of stay was slightly longer in pre-shortage [19 (11-32) days] versus shortage [16 (11-32) days] (p=0...
September 5, 2016: Brazilian Journal of Infectious Diseases
Fuchu Qian, Jiqu Qin, Dongli Li, Hairong Zhang, Zhaowei Tong, Weihong Wang
No abstract text is available yet for this article.
August 24, 2016: Brazilian Journal of Infectious Diseases
Nayara Gonçalves Barbosa, Heloísio Reis, Orlando Cesar Mantese, Marisa Márcia Mussi-Pinhata, Vânia Olivetti Steffen Abdallah, Paulo Pinto Gontijo Filho
No abstract text is available yet for this article.
August 23, 2016: Brazilian Journal of Infectious Diseases
Tizazu Zenebe, Ermias Tefera
Evaluating the outcomes of tuberculosis treatment and understanding the specific reasons for unfavorable treatment outcome are important in evaluating the effectiveness of tuberculosis control program. A retrospective study was conducted to assess tuberculosis treatment outcomes and associated factors among smear positive pulmonary tuberculosis patients in zone-one health facilities of Afar regional state, Ethiopia. A total of 380 smear positive pulmonary tuberculosis patients' registration book recorded with complete information from Jan 2011 to Dec 2013 were analyzed...
August 20, 2016: Brazilian Journal of Infectious Diseases
Diana Yessenia Calva Delgado, Zorayda Patricia Toledo Barrigas, Sofía Genoveva Ochoa Astutillo, Ana Paulina Arévalo Jaramillo, Alessio Ausili
This work performed a phenotypic and genotypic characterization of 79 clinical isolates of Enterobacteriaceae and Pseudomonadaceae collected in hospitals of Southern Ecuadorin 2013. Our results showed a high incidence of β-lactamases and ESBLs with blaTEM and blaCTX-M as the prevalent genes, respectively. By direct sequencing of PCR amplicons, the different β-lactamases and variants of the genes were also distinguished. Our results revealed a predominance of TEM-1 β-lactamase and the presence of different CTX-M variants with a prevalence of CTX-M-15...
July 29, 2016: Brazilian Journal of Infectious Diseases
José Moreira, Felipe Ridolfi, Rodrigo Almeida-Paes, Andrea Varon, Cristiane C Lamas
Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy...
July 26, 2016: Brazilian Journal of Infectious Diseases
Marta Inês Cazentini Medeiros, Bento Vidal de Moura Negrini, Jorgete Maria E Silva, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo Silva Guerra, Denise de Andrade
No abstract text is available yet for this article.
September 2016: Brazilian Journal of Infectious Diseases
Cheng Tan, Wen-Yuan Zhu
No abstract text is available yet for this article.
September 2016: Brazilian Journal of Infectious Diseases
Shambhu Kumar Upadhyaya, Narayan Dutt Pant, Raju Bhandari, Asia Poudel, Bhawana Shrestha
No abstract text is available yet for this article.
September 2016: Brazilian Journal of Infectious Diseases
Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão, Camila Martins de Medeiros, Ryvanne Paulino Rocha, Maria Amanda Correia Lima, Francisco Vagnaldo Fechine
Antiretroviral therapy has increased the survival of patients with HIV/AIDS, thus necessitating health promotion practice with immunization. Vaccines are critical components for protecting people living with HIV/AIDS (PLWHA). The purpose of study was to analyze the vaccination status of PLWHA in outpatient care in Fortaleza, Ceará, Brazil. Cross-sectional study performed from June 2014 to June 2015. The screening was done with patients in antiretroviral therapy, 420 patients underwent screening, but only 99 met the inclusion criteria...
September 2016: Brazilian Journal of Infectious Diseases
Edmir Geraldo Fraga, Antonio Carlos Nicodemo, Jorge Luiz Mello Sampaio
Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C...
September 2016: Brazilian Journal of Infectious Diseases
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