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Alkaloids. Chemistry and Biology

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https://www.readbyqxmd.com/read/29455838/preface
#1
EDITORIAL
Hans-Joachim Knölker
No abstract text is available yet for this article.
2018: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/29455837/benzoxazole-alkaloids-occurrence-chemistry-and-biology
#2
Sitaram Pal, Bhanu Manjunath, Sujit Ghorai, Swarnendu Sasmal
Benzoxazole alkaloids exhibit a diverse array of structures and interesting biological activities. In spite of the extensive research done on the synthesis and biology, till date there is no concise update on this class of alkaloids. This chapter summarizes the literature on benzoxazole alkaloids till March 2017, which covers their isolation, characterization, possible biosynthetic origins, biological activities, and major synthetic approaches. These alkaloids have been broadly classified in the context of their sources, namely (i) fungal origin, (ii) marine origin, and (iii) plant origin...
2018: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/29455836/the-rigidins-isolation-bioactivity-and-total-synthesis-novel-pyrrolo-2-3-d-pyrimidine-analogues-using-multicomponent-reactions
#3
Aletta E van der Westhuyzen, Liliya V Frolova, Alexander Kornienko, Willem A L van Otterlo
Rigidins (2-6) are pyrrolopyrimidine alkaloids isolated from marine tunicates. Since their isolation, refinement of their total syntheses, and biochemical evaluation, interest toward this pyrrolo[2,3-d]pyrimidine scaffold as a medicinal candidate has been triggered. The derivatization of these natural products has led to the discovery of a novel range of 7-deazahypoxanthines, which exhibit extremely potent anticancer activity in human cancer cell lines. A major breakthrough toward the synthesis of rigidin and various rigidin analogues has been the application of multicomponent reactions (MCRs)...
2018: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/29455835/moschamine-related-indole-alkaloids
#4
Chengfeng Xia, Xiaogang Tong
Moschamine-related alkaloids originate mainly from feruloylserotonin by cyclization or dimerization. This review provides a comprehensive overview on the achievements in the field of moschamine-related alkaloids. In the isolation part, a detailed structural characterization of moschamine-related alkaloids is followed by their spectral data. Besides the well-known antioxidative activities, other screened biological properties are also outlined. Since their isolation, different protocols have been developed to synthesize these alkaloids...
2018: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/29455834/alkaloid-synthesis-using-organocatalysts
#5
Hayato Ishikawa, Shinya Shiomi
This chapter covers the literature since the advent, in the 21st century, of total syntheses of alkaloids using enantio- or diastereoselective organocatalytic reactions to construct the alkaloid scaffolds. The details of these alkaloid syntheses are described separately for each basic skeleton, including indole, indoline, oxindole, and piperidine alkaloids.
2018: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28838429/cephalotaxus-alkaloids
#6
REVIEW
Joëlle Pérard-Viret, Laith Quteishat, Rana Alsalim, Jacques Royer, Françoise Dumas
Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60 years. Significant activity against leukemia in mice was demonstrated for extracts of Cephalotaxus. Cephalotaxine (CET) (1), the major alkaloid of this series was isolated from Cephalotaxus drupacea species by Paudler in 1963. The subsequent discovery of promising antitumor activity among new Cephalotaxus derivatives reported by Chinese, Japanese, and American teams triggered extensive structure elucidation and biological studies in this family...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28838428/total-synthesis-of-lundurine-and-related-alkaloids-synthetic-approaches-and-strategies
#7
REVIEW
Shigeru Arai, Masaya Nakajima, Atsushi Nishida
This review focuses on the total synthesis of lundurines A-C. Their main structural feature is a unique cyclopropa[b]indole core that has been found only in these alkaloids. In addition to this characteristic structure, the biological activity makes them as attractive synthetic targets. However, almost two decades passed from their isolation and structural determination in 1995 to their first total synthesis. The first part of this review summarizes the synthetic approaches to the tri- and tetracyclic ring systems of lundurine as well as an inter- and intramolecular cyclopropanation strategy that gives the cyclopropa[b]indole core...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28838427/galbulimima-alkaloids
#8
REVIEW
Uwe Rinner
This chapter provides a comprehensive overview of recent achievements in the area of Galbulimima alkaloids. Following a discussion of the isolation of Galbulimima alkaloids and structural features of members of this fascinating family of secondary metabolites, biological properties of selected compounds are briefly discussed. Furthermore, the proposed biosynthetic routes toward Galbulimima alkaloids are outlined. The main section of the chapter is devoted to a detailed discussion and comparison of all total syntheses of Galbulimima alkaloids published to date...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28838426/acridone-alkaloids
#9
REVIEW
Joseph P Michael
There have been substantial developments in the chemistry and biology of the acridone alkaloids in the 16years since the topic was last reviewed in this series of monographs (2000). The present survey covers the literature from mid-1999 to 2016. A brief overview of the biosynthesis of acridone alkaloids is followed by details of the occurrence and characterization of known alkaloids from new sources, and of novel alkaloids. The classes covered include simple acridone alkaloids, C-prenylacridones, furo[3,2-b]- and furo[2,3-c]acridones, pyrano[3,2-b]- and pyrano[2,3-c]acridones, and dimeric alkaloids containing acridone moieties...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28212702/flavoalkaloids-isolation-biological-activity-and-total-synthesis
#10
Lachlan M Blair, Matthew B Calvert, Jonathan Sperry
The flavoalkaloids possess unique molecular frameworks that contain both a flavonoid and alkaloid component. Flavoalkaloids result from the convergence of distinct biosynthetic pathways, affording natural products that display a wide range of interesting biological activities that would not be expected for flavonoids or alkaloids alone. This chapter collates all the known flavoalkaloids up until early 2016, detailing their isolation, bioactivity, and successful total syntheses.
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28212701/chemistry-and-biology-of-the-pyrrole-imidazole-alkaloids
#11
Thomas Lindel
More than a decade after our last review on the chemistry of the pyrrole-imidazole alkaloids, it was time to analyze once more the developments in that field. The comprehensive article focusses on the total syntheses of pyrrole-imidazole alkaloids that have appeared since 2005. The classic monomeric pyrrole-imidazole alkaloids have all been synthesized, sometimes primarily to demonstrate the usefulness of a new method, as in the case of the related molecules agelastatin A and cyclooroidin with more than 15 syntheses altogether...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/28212700/the-rhazinilam-leuconoxine-mersicarpine-triad-of-monoterpenoid-indole-alkaloids
#12
REVIEW
Magnus Pfaffenbach, Tanja Gaich
The rhazinilam-leuconoxine-mersicarpine triad of monoterpenoid indole alkaloids comprises a variety of diverse natural products with unprecedented structural features and intriguing biological activities. This subfamily of Aspidosperma alkaloids has drawn significant attention from the synthetic community which is reflected by over 20 syntheses within the last 5years. Numerous transformations and strategies have been developed to access the different key structural motifs such as the tetrahydroindolizine, α,β-unsaturated carbinolamide, diaza[5...
2017: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/27276716/in-thematic-volumes-of-the-alkaloids-seminal-developments-in-areas-of-exceptional-interest-are-summarized
#13
EDITORIAL
Hans-Joachim Knölker
No abstract text is available yet for this article.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827885/monoterpenoid-bisindole-alkaloids
#14
REVIEW
Mariko Kitajima, Hiromitsu Takayama
This chapter covers the literature on bisindole alkaloids consisting of monoterpenoid indoles, published up to June 2015. Bisindole alkaloids isolated from plants belonging to the families Apocynaceae and Loganiaceae, including Iboga-vobasine type, Aspidosperma-Aspidosperma type, eburnan-Aspidosperma type, Strychnos-Strychnos type, macroline-macroline type, and so on, are described. Some recent syntheses of monoterpenoid bisindole alkaloids are outlined as well.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827884/the-chemistry-of-the-akuammiline-alkaloids
#15
REVIEW
Gregory L Adams, Amos B Smith
An update on the literature covering the akuammiline family of alkaloids is presented. This chapter begins with a summary of new akuammiline alkaloids reported since 2000 and is followed by an overview of new reported bioactivities of akuammiline alkaloids since 2000. The remainder of the chapter comprises a comprehensive review of the synthetic chemistry that has been reported in the last 50 years concerning akuammiline alkaloids and their structural motifs.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827883/sarpagine-and-related-alkaloids
#16
REVIEW
Ojas A Namjoshi, James M Cook
The sarpagine-related macroline and ajmaline alkaloids share a common biosynthetic origin, and bear important structural similarities, as expected. These indole alkaloids are widely dispersed in 25 plant genera, principally in the family Apocynaceae. Very diverse and interesting biological properties have been reported for this group of natural products. Isolation of new sarpagine-related alkaloids and the asymmetric synthesis of these structurally complex molecules are of paramount importance to the synthetic and medicinal chemists...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827882/sarpagan-ajmalan-type-indoles-biosynthesis-structural-biology-and-chemo-enzymatic-significance
#17
REVIEW
Fangrui Wu, Petra Kerčmar, Chenggui Zhang, Joachim Stöckigt
The biosynthetic pathway of the monoterpenoid indole alkaloid ajmaline in the genus Rauvolfia, in particular Rauvolfia serpentina Benth. ex Kurz, is one of the few pathways that have been comprehensively uncovered. Every step in the progress of plant alkaloid biosynthesis research is due to the endeavors of several generations of scientists and the advancement of technologies. The tissue and cell suspension cultures developed in the 1970s by M.H. Zenk enabled the extraction of alkaloids and crude enzymes for use as experimental materials, thus establishing the foundation for further research on enzymatic reaction networks...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26777309/simple-indolizidine-and-quinolizidine-alkaloids
#18
REVIEW
Joseph P Michael
This review of simple indolizidine and quinolizidine alkaloids (i.e., those in which the parent bicyclic systems are in general not embedded in polycyclic arrays) is an update of the previous coverage in Volume 55 of this series (2001). The present survey covers the literature from mid-1999 to the end of 2013; and in addition to aspects of the isolation, characterization, and biological activity of the alkaloids, much emphasis is placed on their total synthesis. A brief introduction to the topic is followed by an overview of relevant alkaloids from fungal and microbial sources, among them slaframine, cyclizidine, Steptomyces metabolites, and the pantocins...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845063/alkaloids-of-the-annonaceae-occurrence-and-a-compilation-of-their-biological-activities
#19
REVIEW
Ana Silvia Suassuna Carneiro Lúcio, Jackson Roberto Guedes da Silva Almeida, Emídio Vasconcelos Leitão Da-Cunha, Josean Fechine Tavares, Jos Maria Barbosa Filho
This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided...
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845062/the-veratrum-and-solanum-alkaloids
#20
REVIEW
Philipp Heretsch, Athanassios Giannis
This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed.
2015: Alkaloids. Chemistry and Biology
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