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Alkaloids. Chemistry and Biology

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https://www.readbyqxmd.com/read/27276716/in-thematic-volumes-of-the-alkaloids-seminal-developments-in-areas-of-exceptional-interest-are-summarized
#1
EDITORIAL
Hans-Joachim Knölker
No abstract text is available yet for this article.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827885/monoterpenoid-bisindole-alkaloids
#2
REVIEW
Mariko Kitajima, Hiromitsu Takayama
This chapter covers the literature on bisindole alkaloids consisting of monoterpenoid indoles, published up to June 2015. Bisindole alkaloids isolated from plants belonging to the families Apocynaceae and Loganiaceae, including Iboga-vobasine type, Aspidosperma-Aspidosperma type, eburnan-Aspidosperma type, Strychnos-Strychnos type, macroline-macroline type, and so on, are described. Some recent syntheses of monoterpenoid bisindole alkaloids are outlined as well.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827884/the-chemistry-of-the-akuammiline-alkaloids
#3
REVIEW
Gregory L Adams, Amos B Smith
An update on the literature covering the akuammiline family of alkaloids is presented. This chapter begins with a summary of new akuammiline alkaloids reported since 2000 and is followed by an overview of new reported bioactivities of akuammiline alkaloids since 2000. The remainder of the chapter comprises a comprehensive review of the synthetic chemistry that has been reported in the last 50 years concerning akuammiline alkaloids and their structural motifs.
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827883/sarpagine-and-related-alkaloids
#4
REVIEW
Ojas A Namjoshi, James M Cook
The sarpagine-related macroline and ajmaline alkaloids share a common biosynthetic origin, and bear important structural similarities, as expected. These indole alkaloids are widely dispersed in 25 plant genera, principally in the family Apocynaceae. Very diverse and interesting biological properties have been reported for this group of natural products. Isolation of new sarpagine-related alkaloids and the asymmetric synthesis of these structurally complex molecules are of paramount importance to the synthetic and medicinal chemists...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26827882/sarpagan-ajmalan-type-indoles-biosynthesis-structural-biology-and-chemo-enzymatic-significance
#5
REVIEW
Fangrui Wu, Petra Kerčmar, Chenggui Zhang, Joachim Stöckigt
The biosynthetic pathway of the monoterpenoid indole alkaloid ajmaline in the genus Rauvolfia, in particular Rauvolfia serpentina Benth. ex Kurz, is one of the few pathways that have been comprehensively uncovered. Every step in the progress of plant alkaloid biosynthesis research is due to the endeavors of several generations of scientists and the advancement of technologies. The tissue and cell suspension cultures developed in the 1970s by M.H. Zenk enabled the extraction of alkaloids and crude enzymes for use as experimental materials, thus establishing the foundation for further research on enzymatic reaction networks...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26777309/simple-indolizidine-and-quinolizidine-alkaloids
#6
REVIEW
Joseph P Michael
This review of simple indolizidine and quinolizidine alkaloids (i.e., those in which the parent bicyclic systems are in general not embedded in polycyclic arrays) is an update of the previous coverage in Volume 55 of this series (2001). The present survey covers the literature from mid-1999 to the end of 2013; and in addition to aspects of the isolation, characterization, and biological activity of the alkaloids, much emphasis is placed on their total synthesis. A brief introduction to the topic is followed by an overview of relevant alkaloids from fungal and microbial sources, among them slaframine, cyclizidine, Steptomyces metabolites, and the pantocins...
2016: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845063/alkaloids-of-the-annonaceae-occurrence-and-a-compilation-of-their-biological-activities
#7
REVIEW
Ana Silvia Suassuna Carneiro Lúcio, Jackson Roberto Guedes da Silva Almeida, Emídio Vasconcelos Leitão Da-Cunha, Josean Fechine Tavares, Jos Maria Barbosa Filho
This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided...
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845062/the-veratrum-and-solanum-alkaloids
#8
REVIEW
Philipp Heretsch, Athanassios Giannis
This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed.
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845061/the-alkaloids-of-the-madangamine-group
#9
REVIEW
Mercedes Amat, Maria Pérez, Roberto Ballette, Stefano Proto, Joan Bosch
This chapter is focused on madangamines, a small group of complex diamine alkaloids isolated from marine sponges of the order Haplosclerida, and covers their isolation, characterization, biogenesis, biological activity, and synthesis. Structurally, madangamines are pentacyclic alkaloids with an unprecedented skeletal type, characterized by a common diazatricyclic core and two peripheral macrocyclic rings. The isolation of these alkaloids from Xestospongia ingens (madangamines A-E) and Pachychalina alcaloidifera (madangamine F) is described in detail...
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845060/the-homalium-alkaloids-isolation-synthesis-and-absolute-configuration-assignment
#10
REVIEW
Stephen G Davies, James E Thomson
The structurally related natural products (-)-homaline, (-)-hopromine, (-)-hoprominol, and (-)-hopromalinol have been collectively termed the homalium alkaloids. All four alkaloids possess bis-ζ-azalactam structures, but differ only by the identities of the side chain on each lactam ring. Since their isolation (from the leaves of Homalium pronyense Guillaum found in the forests of New Caledonia), there have been several syntheses of homaline, hopromine, hoprominol, and hopromalinol in both racemic and enantiopure forms...
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/25845059/the-securinega-alkaloids
#11
REVIEW
Eqor Chirkin, William Atkatlian, François-Hugues Porée
Securinega alkaloids represent a family of plant secondary metabolites known for 50 years. Securinine (1), the most abundant and studied alkaloid of this series was isolated by Russian researchers in 1956. In the following years, French and Japanese scientists reported other Securinega compounds and extensive work was done to elucidate their intriguing structures. The homogeneity of this family relies mainly on its tetracyclic chemical backbone, which features a butenolide moiety (cycle D) and an azabicyclo[3...
2015: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26521652/preface
#12
EDITORIAL
Hans-Joachim Knölker
No abstract text is available yet for this article.
2014: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26521651/the-saraine-alkaloids
#13
Bernard Delpech
Saraines have been isolated by the group of Cimino from the marine sponge Reniera sarai collected in the Bay of Naples. These alkaloids can be classified into two categories, depending on the type of their structure. Saraines 1-3 and isosaraines 1-3 are characterized by a trans-2-oxoquinolizidine moiety bound directly to a tetrahydropyridine ring, both nuclei being also linked by two alkyl chains of different lengths. On the other hand, saraines A-C and misenine present a diazatricyclic central core, showing an unusual interaction between an aldehyde and a tertiary amine and giving them a zwitterionic character, and flanked with two chains forming macrocycles...
2014: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26521650/the-hasubanan-and-acutumine-alkaloids
#14
Sandra M King, Seth B Herzon
Research in the hasubanan and acutumine alkaloid fields up to 1970 was discussed under "morphine alkaloids" in Volume 13 of this chapter. Advances in the field of hasubanan alkaloids from 1971 to 1975 were reviewed in Volume 16 and from 1976 to 1986 in Volume 33. This chapter extends the information in the three preceding reviews to hasubanan alkaloid literature published from 1987 to June 2013. This chapter covers acutumine alkaloid literature since (-)-acutumine (3) was isolated in 1929. This chapter includes occurrence and physical constants, new alkaloids, synthesis, biosynthesis, and pharmacology...
2014: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26521649/the-chemistry-of-hapalindoles-fischerindoles-ambiguines-and-welwitindolinones
#15
Vikram Bhat, Apurva Dave, James A MacKay, Viresh H Rawal
Isolated from diverse cyanobacteria, the hapalindole family of indole alkaloids comprises over 80 interrelated natural products. The family is further divided into several subclasses including the hapalindoles, fischerindoles, ambiguines, and welwitindolinones, each sharing one or more of the many common structural motifs, including an indole or oxindole core, a highly functionalized cyclohexane unit fused to the indole at C-3, and the uncommon isonitrile or isothiocyanate functionalities. Reported here is a comprehensive review covering the isolation of all currently known hapalindole-type alkaloids, the biological activity for several members of the family, and the proposed biosyntheses that give rise to the intricate structural diversity within the family...
2014: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/26521648/marine-bi-bis-and-trisindole-alkaloids
#16
Clinton G L Veale, Michael T Davies-Coleman
This chapter, covering the chemistry literature up until June 2013 and comprising 142 references, records the chemical structures of 130 bi-, bis-, and trisindole alkaloids isolated from a plethora of marine phyla including bacteria, algae, bryozoans, sponges, mollusks, hard corals, and ascidians. While the vast majority of bisindoles have been isolated from marine sponges, biindoles are more commonly found in red algae species than sponges. Trisindoles are far less common than bisindoles in the marine environment and have been limited to two species of sponge and a single species of marine microbe...
2014: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/24712099/cephalostatins-and-ritterazines
#17
REVIEW
Martín A Iglesias-Arteaga, Jacek W Morzycki
This review article is a tribute to the numerous chemists whose relentless effort for the last quarter of a century resulted in the isolation, identification, and finally the chemical synthesis of a family of bis-steroidal pyrazine alkaloids of marine origin. In the task of defeating cancer, the search for bioactive substances among the naturally occurring compounds is, without any doubt, a preferential approach. The remarkable contribution of Petitt, Fusetani, and their coworkers allowed to discover this family of marine alkaloids that emerge as potential therapeutic anticancer agents, although there is still a long way to go...
2013: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/24712098/lycopodium-alkaloids-synthetic-highlights-and-recent-developments
#18
REVIEW
Peter Siengalewicz, Johann Mulzer, Uwe Rinner
No abstract text is available yet for this article.
2013: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/16173400/the-marine-bromotyrosine-derivatives
#19
REVIEW
Jiangnan Peng, Jing Li, Mark T Hamann
No abstract text is available yet for this article.
2005: Alkaloids. Chemistry and Biology
https://www.readbyqxmd.com/read/14593858/the-manzamine-alkaloids
#20
REVIEW
Jin-Feng Hu, Mark T Hamann, Russell Hill, Michelle Kelly
No abstract text is available yet for this article.
2003: Alkaloids. Chemistry and Biology
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