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Pharmaceutical Biology

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https://www.readbyqxmd.com/read/29781354/effects-and-possible-mechanisms-of-alpinia-officinarum-ethanol-extract-on-indomethacin-induced-gastric-injury-in-rats
#1
Jingwen Gong, Zhong Zhang, Xuguang Zhang, Feng Chen, Yinfeng Tan, Hailong Li, Jie Jiang, Junqing Zhang
CONTEXT: Alpinia officinarum Hance (Zingiberoside) has a long history in treating gastrointestinal diseases, but its mechanisms of action are not yet known. OBJECTIVE: To investigate the effects and underlying mechanisms of the ethanol extract of A. officinarum rhizomes in an indomethacin-induced gastric injury rat model. MATERIAL AND METHODS: Indomethacin (0.3 g/kg) was orally administered to Sprague-Dawley rats to induce gastric damage; after 7 h, the rats were treated with 0...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29772938/the-suppressive-effect-of-the-three-herb-extract-mixture-on-vascular-and-liver-inflammation-in-atherogenic-diet-with-high-fructose-fed-mice
#2
Hae Seong Song, Hyun Jung Koo, Bong Kyun Park, Jeong Eun Kwon, Seon-A Jang, Hyun Jin Baek, Se Young Kim, Sung Ryul Lee, Se Chan Kang
CONTEXT: Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L. var. rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity. OBJECTIVES: The synergistic effect of three-herb mixture of C. wilfordii, A. lappa and D. opposita was determined on aortic and liver inflammatory responses. MATERIALS AND METHODS: CWE, ALE and DOE were prepared from the root of C...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29656686/lipopolysaccharide-from-rhodobacter-sphaeroides-tlr4-antagonist-attenuates-hypersensitivity-and-modulates-nociceptive-factors
#3
Agnieszka M Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
CONTEXT: Accumulating evidence has demonstrated that Toll-like receptors (TLRs), especially TLR4 localized on microglia/macrophages, may play a significant role in nociception. OBJECTIVE: We examine the role of TLR4 in a neuropathic pain model. Using behavioural/biochemical methods, we examined the influence of TLR4 antagonist on levels of hypersensitivity and nociceptive factors whose contribution to neuropathy development has been confirmed. MATERIALS AND METHODS: Behavioural (von Frey's/cold plate) tests were performed with Wistar male rats after intrathecal administration of a TLR4 antagonist (LPS-RS ULTRAPURE (LPS-RSU), 20 μG: lipopolysaccharide from Rhodobacter sphaeroides, InvivoGen, San Diego, CA) 16 H and 1 h before chronic constriction injury (cci) to the sciatic nerve and then daily for 7 d...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29656672/screening-of-in-vitro-antimicrobial-activity-of-plants-used-in-traditional-indonesian-medicine
#4
Andreas Romulo, Ervizal A M Zuhud, Johana Rondevaldova, Ladislav Kokoska
CONTEXT: In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods. OBJECTIVE: This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesian traditional medicine for treatment against Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29651912/effects-of-diclofenac-on-the-pharmacokinetics-of-celastrol-in-rats-and-its-transport
#5
Zengfu Wang, Dali Chen, Zhongwei Wang
CONTEXT: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb-drug interaction potential between diclofenac and celastrol is still unknown. OBJECTIVE: This study investigates the effects of diclofenac on the pharmacokinetics of celastrol in rats. MATERIALS AND METHODS: Twelve male Sprague-Dawley rats were divided into two groups and received celastrol (1 mg/kg) or both celastrol (1 mg/kg) and diclofenac (10 mg/kg) by oral gavage, and blood samples were collected via the oculi chorioideae vein and determined using the LC-MS method developed in this study...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29648503/brazilian-medicinal-plants-with-corroborated-anti-inflammatory-activities-a-review
#6
Victor Pena Ribeiro, Caroline Arruda, Mohamed Abd El-Salam, Jairo Kenupp Bastos
CONTEXT: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity. OBJECTIVES: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29569964/zanthoxylum-alatum-abrogates-lipopolysaccharide-induced-depression-like-behaviours-in-mice-by-modulating-neuroinflammation-and-monoamine-neurotransmitters-in-the-hippocampus
#7
Chandana Choudhury Barua, Prakash Haloi, Beenita Saikia, Kunjbihari Sulakhiya, Debesh Chandra Pathak, Shantanu Tamuli, Hooriah Rizavi, Xinguo Ren
CONTEXT: Depression is an inflammatory, commonly occurring and lethal psychiatric disorder having high lifetime prevalence. Zanthoxylum alatum Roxb. (Rutaceae), commonly called Timur, has high medicinal value and is used ethnomedicinally for the treatment of various diseases. OBJECTIVE: To evaluate the effect of hexane extract of Z. alatum seeds (ZAHE) on lipopolysaccharide (LPS)-induced depression-like behaviour in Swiss albino mice. MATERIALS AND METHODS: Mice were treated with ZAHE (100 and 200 mg/kg, p...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29564971/isolation-and-identification-of-three-new-chromones-from-the-leaves-of-pimenta-dioica-with-cytotoxic-oestrogenic-and-anti-oestrogenic-effects
#8
Brian J Doyle, Temitope O Lawal, Tracie D Locklear, Lorraina Hernandez, Alice L Perez, Udeshi Patel, Shitalben Patel, Gail B Mahady
CONTEXT: Pimenta dioica (L.) Merr. (Myrtaceae) is used in Costa Rican traditional medicine for women's health. Our previous work showed that P. dioica extracts were oestrogenic. OBJECTIVES: This work identifies phytochemicals from P. dioica that are responsible for the plant's oestrogen-like activities. MATERIALS AND METHODS: P. dioica leaves were collected in Costa Rica in 2005. Fractions resulting from chromatographic separation of a methanol extract were tested at 50 μg/mL in a competitive oestrogen receptor-binding assay...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29560776/vascular-mechanisms-underlying-the-hypotensive-effect-of-rumex-acetosa
#9
Hafiz Misbah-Ud-Din Qamar, Rahila Qayyum, Umme Salma, Shamim Khan, Taous Khan, Abdul Jabbar Shah
CONTEXT: Rumex acetosa L. (Polygonaceae) is well known in traditional medicine for its therapeutic efficacy as an antihypertensive. OBJECTIVE: The study investigates antihypertensive potential of crude methanol extract (Ra.Cr) and fractions of Rumex acetosa in normotensive and hypertensive rat models and probes the underlying vascular mechanisms. MATERIALS AND METHODS: Ra.Cr and its fractions were tested in vivo on normotensive and hypertensive Sprague-Dawley rats under anaesthesia for blood pressure lowering effect...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29560767/protective-effect-of-compound-danshen-salvia-miltiorrhiza-dripping-pills-alone-and-in-combination-with-carbamazepine-on-kainic-acid-induced-temporal-lobe-epilepsy-and-cognitive-impairment-in-rats
#10
Chen Jia, Shanshan Han, Liming Wei, Xiangji Dang, Qianqian Niu, Mengyu Chen, Boqun Cao, Yuting Liu, Haisheng Jiao
CONTEXT: Temporal lobe epilepsy (TLE) is resistant to antiepileptic drugs (AEDs) and is associated with cognitive impairment. The modern Chinese medicine, compound Danshen dripping pills (CDDP), is clinically effective in treating epilepsy and improving cognitive impairment. OBJECTIVE: This study evaluated the protective effects of CDDP alone and in combination with carbamazepine (CBZ) on kainic acid-induced TLE and cognitive impairment in rats. MATERIALS AND METHODS: Sprague-Dawley rats were randomly divided into five groups: control (sham operated), model, CDDP, CBZ and combined...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29540097/crocin-exerts-anti-inflammatory-and-anti-arthritic-effects-on-type-ii-collagen-induced-arthritis-in-rats
#11
Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu, Ying Wen
CONTEXT: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. OBJECTIVE: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. MATERIALS AND METHODS: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29529970/antibacterial-effects-of-18-medicinal-plants-used-by-the-khyang-tribe-in-bangladesh
#12
Md Shahadat Hossan, Hassan Jindal, Sarah Maisha, Chandramathi Samudi Raju, Shamala Devi Sekaran, Veeranoot Nissapatorn, Fatima Kaharudin, Lim Su Yi, Teng Jin Khoo, Mohammed Rahmatullah, Christophe Wiart
CONTEXT: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. OBJECTIVE: The present study examines the antibacterial properties of 18 medicinal plants used by the Khyang tribe in day-to-day practice against human pathogenic bacteria...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29521149/protective-properties-of-geniposide-against-uv-b-induced-photooxidative-stress-in-human-dermal-fibroblasts
#13
Daehyun Shin, Sihyeong Lee, Yu-Hua Huang, Hye-Won Lim, Yoonjin Lee, Kyounghee Jang, Yongwan Cho, Sang Jun Park, Dae-Duk Kim, Chang-Jin Lim
CONTEXT: Geniposide (genipin-1-O-β-d-glucoside) is a major bioactive ingredient in the fruits of gardenia [Gardenia jasminoides J. Ellis (Rubiaceae)], a traditional herbal medicine in Asian countries. OBJECTIVE: This work assesses the skin anti-photoaging potential of geniposide in human dermal fibroblasts under UV-B irradiation. MATERIALS AND METHODS: The anti-photoaging property of geniposide, at varying concentrations (5, 12 and 30 μM) treated for 30 min prior to UV-B irradiation, was evaluated by analysing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2), glutathione (GSH), superoxide dismutase (SOD), nuclear factor erythroid 2-related factor 2 (Nrf2) and cellular viability...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29521146/desalted-salicornia-europaea-powder-and-its-active-constituent-trans-ferulic-acid-exert-anti-obesity-effects-by-suppressing-adipogenic-related-factors
#14
Md Mahbubur Rahman, Myung-Jin Kim, Jin-Hyoung Kim, Sok-Ho Kim, Hyeon-Kyu Go, Mee-Hyang Kweon, Do-Hyung Kim
CONTEXT: Salicornia europaea (Amaranthaceae) (SE) has been shown to reduce obesity, but it remains a problem as a food supplement because of its high salt content (25-35% NaCl). OBJECTIVES: This study investigated the anti-obesity effects and mechanism of action of desalted SE powder (DSP). MATERIALS AND METHODS: Sprague-Dawley rats (n = 50) were divided into a normal control group (NC), a high-fat diet (HFD)-induced obesity control group (HFD), and HFD groups co-administered DSP (250 and 500 mg/kg) or Garcinia cambogia (Clusiaceae) extract (GE, 200 mg/kg, standard control) orally each day for 12 weeks...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29521141/anti-neuroinflammatory-effects-of-cudraflavanone-a-isolated-from-the-chloroform-fraction-of-cudrania-tricuspidata-root-bark
#15
Kwan-Woo Kim, Tran Hong Quang, Wonmin Ko, Dong-Cheol Kim, Chi-Su Yoon, Hyuncheol Oh, Youn-Chul Kim
CONTEXT: Cudrania tricuspidata Bureau (Moraceae) is an important source of traditional Korean and Chinese medicines used to treat neuritis and inflammation. OBJECTIVE: The anti-neuroinflammatory effects of cudraflavanone A isolated from a chloroform fraction of C. tricuspidata were investigated in LPS-induced BV2 cells. MATERIALS AND METHODS: Cudraflavanone A was isolated from the root of C. tricuspidata, and its structure was determined by MS and NMR data...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29513129/in-vivo-anti-ulcerogenic-effect-of-okra-abelmoschus-esculentus-on-ethanol-induced-acute-gastric-mucosal-lesions
#16
Deniz Ortaç, Mustafa Cemek, Turan Karaca, Mehmet E Büyükokuroğlu, Zafer Ö Özdemir, Ayşe Tuba Kocaman, Sadık Göneş
CONTEXT: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis. OBJECTIVE: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models. MATERIALS AND METHODS: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que)...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29486635/the-predictive-utility-of-the-plant-phylogeny-in-identifying-sources-of-cardiovascular-drugs
#17
Emily Guzman, Jeanmaire Molina
CONTEXT: Cardiovascular disease (CVD) is the number one cause of death globally, responsible for over 17 million (31%) deaths in the world. Novel pharmacological interventions may be needed given the high prevalence of CVD. OBJECTIVE: In this study, we aimed to find potential new sources of cardiovascular (CV) drugs from phylogenetic and pharmacological analyses of plant species that have experimental and traditional CV applications in the literature. MATERIALS AND METHODS: We reconstructed the molecular phylogeny of these plant species and mapped their pharmacological mechanisms of action on the phylogeny...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29421944/metabolomic-evaluation-of-euphorbia-pekinensis-induced-nephrotoxicity-in-rats
#18
Zhenzhen Liu, Yan Zeng, Pengyi Hou
CONTEXT: Euphorbia pekinensis Rupr. (Euphorbiaceae) has long been used in the Orient, while its clinical use was limited due to its nephrotoxic effect. OBJECTIVE: The possible mechanism of nephrotoxicity of Euphorbia pekinensis (EPR) and its related constituents were investigated. MATERIALS AND METHODS: Petroleum ether (PE), acetic ether (AE) and n-butanol (BUT) extracted sections of EPR were separately given to Wistar rats by gavage at the dose of 3 g/kg/day for 10 weeks to determine the nephrotoxic section of EPR...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29409377/the-role-of-artichoke-leaf-tincture-cynara-scolymus-in-the-suppression-of-dna-damage-and-atherosclerosis-in-rats-fed-an-atherogenic-diet
#19
Natasa Bogavac-Stanojevic, Jelena Kotur Stevuljevic, Darko Cerne, Janja Zupan, Janja Marc, Zorica Vujic, Milkica Crevar-Sakac, Miron Sopic, Jelena Munjas, Miroslav Radenkovic, Zorana Jelic-Ivanovic
CONTEXT: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. OBJECTIVES: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. MATERIALS AND METHODS: Eighteen male Wistar albino rats were divided into three groups (n = 6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29385888/andrographolide-relieved-pathological-pain-generated-by-spared-nerve-injury-model-in-mice
#20
Huang-Chi Wang, Hsin-Sheng Tsay, Hui-Nung Shih, Yi-An Chen, Kai-Ming Chang, Dinesh Chandra Agrawal, Siendong Huang, Yi-Lo Lin, Meng-Jen Lee
CONTEXT: Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia. OBJECTIVE: The objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model. MATERIAL AND METHODS: Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group)...
December 2018: Pharmaceutical Biology
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