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Pharmaceutical Biology

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https://www.readbyqxmd.com/read/28508681/correction-to-abhishek-et%C3%A2-al-antioxidant-and-anti-inflammatory-activities-of-aerva-pseudotomentosa-leaves
#1
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May 16, 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28466672/corrigendum
#2
(no author information available yet)
No abstract text is available yet for this article.
May 3, 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#3
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524742/piqueria-trinervia-as-a-source-of-metabolites-against-giardia-intestinalis
#4
Yadira Rufino-González, Martha Ponce-Macotela, Manuel Jiménez-Estrada, Candy N Jiménez-Fragoso, Guadalupe Palencia, Gabriel Sansón-Romero, Anahi Anzo-Osorio, Mario N Martínez-Gordillo
CONTEXT: Piqueria trinervia Cav. (Asteraceae) is a plant species with a long history in traditional medicine to cure diarrhoea and other digestive disorders. OBJECTIVE: The study investigates the antigiardial activity of piquerol, trinervinol, red oil and two fractions (F1 and F2) from P. trinervia. MATERIALS AND METHODS: P. trinervia was collected in the Ajusco in Mexico City. Aerial parts were ground and mixed with water to obtain the extract, which was treated with dichloromethane to isolate piquerol and trinervinol (P & T)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28521597/determination-of-cepharanthine-in-rat-plasma-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#5
Yingbin Deng, Weijun Wu, Sunzhi Ye, Wei Wang, Zhiyi Wang
CONTEXT: Cepharanthine (CPA) has been reported to possess a wide range of pharmacological activities. OBJECTIVE: This study investigates the pharmacokinetic characteristics after oral or intravenous administration of CPA by using a sensitive and rapid LC-MS/MS method. MATERIALS AND METHODS: A sensitive and rapid LC-MS/MS method was developed for the determination of CPA in Sprague-Dawley rat plasma. Twelve rats were equally randomized into two groups, including the intravenous group (1 mg/kg) and the oral group (10 mg/kg)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28508699/antimicrobial-anticancer-and-antioxidant-compounds-from-premna-resinosa-growing-in-saudi-arabia
#6
Dina A Albadawi, Ramzi A Mothana, Jamal M Khaled, Abdelkhader E Ashour, Ashok Kumar, Sheikh F Ahmad, Mansour S Al-Said, Adnan J Al-Rehaily, Nawal M Almusayeib
CONTEXT: Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage. OBJECTIVE: This study evaluates the anticancer, antimicrobial and antioxidant activities of P. resinosa, and isolates some responsible constituents. MATERIALS AND METHODS: The methanol extract of P. resinosa aerial parts and its fractions (n-hexane, dichloromethane, ethyl acetate and n-butanol) were tested...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28502237/investigation-of-the-effective-components-of-the-flowers-of-trollius-chinensis-from-the-perspectives-of-intestinal-bacterial-transformation-and-intestinal-absorption
#7
Lina Guo, Shanshan Qiao, Junhong Hu, Deli Li, Shiqi Zheng, Duozhi Shi, Junxiu Liu, Rufeng Wang
CONTEXT: The flowers of Trollius chinensis Bunge (Ranunculaceae), used for respiratory tract infections, mainly contain flavonoids, phenolic acids, and alkaloids; however, the effective components are debatable because of their unclear in vivo activities. OBJECTIVE: This study investigates the effective components from the perspectives of biotransformation and absorption. MATERIALS AND METHODS: Both single person derived- and multiple people-derived intestinal florae were used to investigate the biotransformation of aqueous extract of the flowers of T...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28494681/acute-and-sub-chronic-toxicity-of-cajanus-cajan-leaf-extracts
#8
Rong Tang, Ru-Hua Tian, Jia-Zhong Cai, Jun-Hui Wu, Xiao-Ling Shen, Ying-Jie Hu
CONTEXT: The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported. OBJECTIVE: This study examines the toxicological profiles of C. cajan leaf extracts. MATERIALS AND METHODS: The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichloroform and n-butanol extracts (DEC and BEC)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28486830/ethnomedicinal-uses-phytochemistry-and-pharmacological-aspects-of-the-genus-premna-a-review
#9
Roza Dianita, Ibrahim Jantan
CONTEXT: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. OBJECTIVES: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28478745/epigallocatechin-3-gallate-counters-cisplatin-toxicity-of-rat-testes
#10
Amr A Fouad, Hatem O Qutub, Abo Elyazied A Fouad, Ahmed M Audeh, Walid N Al-Melhim
CONTEXT: Epigallocatechin-3-gallate (EG), the main active flavonoid in green tea, has well-known anti-inflammatory, antioxidant, and anti-apoptotic activities. OBJECTIVE: The EG protection against testicular injury induced by cisplatin was studied in Sprague-Dawley rats. MATERIALS AND METHODS: Cisplatin (10 mg/kg, i.p) was given as a single injection to rats. EG was given at 40 and 80 mg/kg/day, i.p., for 5 days, starting the same day of cisplatin insult...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28466663/inhibitory-effects-of-tanshinones-towards-the-catalytic-activity-of-udp-glucuronosyltransferases-ugts
#11
Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang
CONTENTS: Danshen is a popular herb employed to treat cardiovascular and cerebrovascular diseases worldwide. Danshen-drug interaction has not been well studied. OBJECTIVE: The inhibitory effects of four major tanshinones (tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone I) on UDP-glucuronosyltransferases (UGTs) isoforms were determined to better understand the mechanism of danshen-prescription drugs interaction. MATERIALS AND METHODS: In vitro recombinant UGTs-catalyzed 4-methylumbelliferone (4-MU) glucuronidation reaction was employed...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28454506/antioxidant-and-anti-inflammatory-activities-of-aerva-pseudotomentosa-leaves
#12
Abhishek Pandey, Atul Kaushik, Manish Wanjari, Yadu Nandan Dey, Bhagat Singh Jaiswal, Anamika Dhodi
CONTEXT: Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae), commonly called 'Bui', is a medicinal plant of the arid region. It is used for the treatment of inflammatory disorders, such as rheumatic pain, and healing of wounds, which are associated with oxidative stress. OBJECTIVE: The present study evaluated the antioxidant potential of Aerva pseudotomentosa leaves by in vitro models and its anti-inflammatory effect in rats. MATERIAL AND METHODS: The aqueous extract (APAE) was analyzed by HPTLC and HPLC...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28454505/equisetum-giganteum-influences-the-ability-of-candida-albicans-in-forming-biofilms-over-the-denture-acrylic-resin-surface
#13
Rafaela Alves da Silva, Laura Pozato Bernardo, Jessica Monique Lopes Moreno, Vanessa Soares Lara, Vinicius Carvalho Porto
CONTEXT: Equisetum giganteum L. (Equisetaceae) is an endemic plant of Central and South America used in traditional medicine. Natural drugs have been frequently used in the treatment of a myriad of diseases, proving to be an alternative to synthetic chemicals, and have been intensively studied in the prevention of sicknesses, including oral diseases. OBJECTIVE: This study evaluated the in vitro antiadherent activity of E. giganteum extract against Candida albicans biofilms...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28447517/hepatoprotective-potential-of-phyllanthus-muellarianus-leaf-extract-studies-on-hepatic-oxidative-stress-and-inflammatory-biomarkers
#14
Taofeek O Ajiboye, Fatimah M Ahmad, Airat O Daisi, Aminat A Yahaya, Oluwayemisi B Ibitoye, Hamdalat F Muritala, Taofik O Sunmonu
CONTEXT: Leaves of Phyllanthus muellarianus (Kuntze) Exell. (Euphorbiacea) are widely used in the management of liver disorders in Nigeria. However, no there is no scientific validation to support this use. OBJECTIVE: Hepatoprotective effect of Phyllanthus muellarianus aqueous leaf extract was investigated in acetaminophen-induced liver injury mice. MATERIALS AND METHODS: Hepatoprotective effect of Phyllanthus muellarianus aqueous leaf extract was evaluated in acetaminophen-induced hepatic damage in Swiss albino mice using biomarkers of hepatocellular indices, oxidative stress, proinflammatory factors and lipid peroxidation...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28447514/neuroprotective-effects-of-ellagic-acid-on-cuprizone-induced-acute-demyelination-through-limitation-of-microgliosis-adjustment-of-cxcl12-il-17-il-11-axis-and-restriction-of-mature-oligodendrocytes-apoptosis
#15
Nima Sanadgol, Fereshteh Golab, Zakiyeh Tashakkor, Nooshin Taki, Samira Moradi Kouchi, Ali Mostafaie, Mehdi Mehdizadeh, Mohammad Abdollahi, Ghorban Taghizadeh, Mohammad Sharifzadeh
CONTEXT: Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities. However, the efficacy of EA has not been examined in neuropathologic conditions. OBJECTIVE: In vivo neuroprotective effects of EA on cuprizone (cup)-induced demyelination were evaluated. MATERIAL AND METHODS: C57BL/6 J mice were fed with chow containing 0.2% cup for 4 weeks to induce oligodendrocytes (OLGs) depletion predominantly in the corpus callosum (CC)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28447512/centella-asiatica-enhances-hepatic-antioxidant-status-and-regulates-hepatic-inflammatory-cytokines-in-type-2-diabetic-rats
#16
Ayodeji B Oyenihi, Novel N Chegou, Oluwafemi O Oguntibeju, Bubuya Masola
CONTEXT: Neutralizing the over-activation of oxidative stress and inflammation remains an important goal in the management of type 2 diabetes mellitus (T2DM). Centella asiatica (L.) Urban (Apiaceae) (CA) has been used in traditional folklore in Africa and Asia to treat various ailments including diabetes. OBJECTIVE: We investigated the hepatic antioxidant and anti-inflammatory potential of methanol extract of CA leaves in T2DM. MATERIALS AND METHODS: T2DM was induced in male Sprague-Dawley rats with 10% fructose in drinking water for 14 days followed by a single intraperitoneal injection of streptozotocin (40 mg/kg b...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28447506/anti-inflammatory-and-gastroprotective-potential-of-leaf-essential-oil-of-cinnamomum-glanduliferum-in-ethanol-induced-rat-experimental-gastritis
#17
Samar S Azab, Gehad A Abdel Jaleel, Omayma A Eldahshan
CONTEXT: Nothing could be found in the literature concerning Cinnamomum glanduliferum (Wall) Meissn (Lauraceae) bark (CG) in Egypt. OBJECTIVE: To investigate CG volatile oil chemically and its anti-inflammatory and gastroprotective effects. MATERIALS AND METHODS: Essential oils were investigated by GC-MS. Leaves oil was assessed at doses of 250, 500 and 1000 mg/kg for its anti-inflammatory effect against carrageenan-induced rat oedema model...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28431483/bioassay-guided-isolation-identification-of-compounds-from-origanum-rotundifolium-and-investigation-of-their-antiproliferative-and-antioxidant-activities
#18
Ramazan Erenler, Bilal Meral, Ozkan Sen, Mahfuz Elmastas, Ali Aydin, Ozgur Eminagaoglu, Gulacti Topcu
CONTEXT: Origanum (Lamiaceae) has been used in food and pharmaceutical industries. OBJECTIVE: Isolation and identification of bioactive compounds from Origanum rotundifolium Boiss. and investigation of their antiproliferative and antioxidant activities. MATERIALS AND METHODS: The aerial part of O. rotundifolium was dried and powdered (1.0 kg ±2.0 g) then extracted with hexane, ethyl acetate, methanol and water. Solvent (3 × 1 L) was used for each extraction for a week at room temperature...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28427293/beneficial-effects-of-tyrosol-on-altered-glycoprotein-components-in-streptozotocin-induced-diabetic-rats
#19
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari
CONTEXT: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases. OBJECTIVE: This study evaluates the effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Diabetes mellitus was induced in male Wistar rats by streptozotocin (40 mg/kg body weight)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28427292/chemical-analyses-and-in-vitro-and-in-vivo-toxicity-of-fruit-methanol-extract-of-sechium-edule-var-nigrum-spinosum
#20
Itzen Aguiñiga-Sánchez, Jorge Cadena-Íñiguez, Edelmiro Santiago-Osorio, Guadalupe Gómez-García, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez, Mirna Ruíz-Ramos, Víctor Manuel Cisneros-Solano, Edgar Ledesma-Martínez, Angel de Jesus Delgado-Bordonave, Ramón Marcos Soto-Hernández
CONTEXT: Sechium edule (Jacq.) Sw. (Cucurbitaceae) is used in ethnomedicine, but the diversity of the varietal groups of this species has not often been considered. This is important because we previously reported that different variety of species exhibit different activities across different tumor cell lines. OBJECTIVE: This study investigates the chemical composition and biological activities of extracts obtained from S. edule var. nigrum spinosum. MATERIALS AND METHODS: The leukemia P388 cell line and mononuclear bone marrow cells (MNCBMs) were treated with the extract at a concentration ranging from 40 to 2370 μg/mL for cytotoxicity and viability assays...
December 2017: Pharmaceutical Biology
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