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Pharmaceutical Biology

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https://www.readbyqxmd.com/read/28431483/bioassay-guided-isolation-identification-of-compounds-from-origanum-rotundifolium-and-investigation-of-their-antiproliferative-and-antioxidant-activities
#1
Ramazan Erenler, Bilal Meral, Ozkan Sen, Mahfuz Elmastas, Ali Aydin, Ozgur Eminagaoglu, Gulacti Topcu
CONTEXT: Origanum (Lamiaceae) has been used in food and pharmaceutical industries. OBJECTIVE: Isolation and identification of bioactive compounds from Origanum rotundifolium Boiss. and investigation of their antiproliferative and antioxidant activities. MATERIALS AND METHODS: The aerial part of O. rotundifolium was dried and powdered (1.0 kg ±2.0 g) then extracted with hexane, ethyl acetate, methanol and water. Solvent (3 × 1 L) was used for each extraction for a week at room temperature...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28427293/beneficial-effects-of-tyrosol-on-altered-glycoprotein-components-in-streptozotocin-induced-diabetic-rats
#2
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari
CONTEXT: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases. OBJECTIVE: This study evaluates the effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Diabetes mellitus was induced in male Wistar rats by streptozotocin (40 mg/kg body weight)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28427292/chemical-analyses-and-in-vitro-and-in-vivo-toxicity-of-fruit-methanol-extract-of-sechium-edule-var-nigrum-spinosum
#3
Itzen Aguiñiga-Sánchez, Jorge Cadena-Íñiguez, Edelmiro Santiago-Osorio, Guadalupe Gómez-García, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez, Mirna Ruíz-Ramos, Víctor Manuel Cisneros-Solano, Edgar Ledesma-Martínez, Angel de Jesus Delgado-Bordonave, Ramón Marcos Soto-Hernández
CONTEXT: Sechium edule (Jacq.) Sw. (Cucurbitaceae) is used in ethnomedicine, but the diversity of the varietal groups of this species has not often been considered. This is important because we previously reported that different variety of species exhibit different activities across different tumor cell lines. OBJECTIVE: This study investigates the chemical composition and biological activities of extracts obtained from S. edule var. nigrum spinosum. MATERIALS AND METHODS: The leukemia P388 cell line and mononuclear bone marrow cells (MNCBMs) were treated with the extract at a concentration ranging from 40 to 2370 μg/mL for cytotoxicity and viability assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28424024/molecular-profiling-and-bioactive-potential-of-an-endophytic-fungus-aspergillus-sulphureus-isolated-from-sida-acuta-a-medicinal-plant
#4
M Murali, C Mahendra, P Hema, N Rajashekar, A Nataraju, M S Sudarshana, K N Amruthesh
CONTEXT: Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. OBJECTIVE: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. MATERIALS AND METHODS: Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28415906/effect-of-piplartine-and-cinnamides-on-leishmania-amazonensis-plasmodium-falciparum-and-on-peritoneal-cells-of-swiss-mice
#5
Keline Medeiros de Araújo-Vilges, Stefan Vilges de Oliveira, Shirley Claudino Pereira Couto, Harold Hilarion Fokoue, Gustavo Adolfo Sierra Romero, Massuo Jorge Kato, Luiz Antonio Soares Romeiro, José Roberto Souza Almeida Leite, Selma Aparecida Souza Kuckelhaus
CONTEXT: Plants of the Piperaceae family produce piplartine that was used to synthesize the cinnamides. OBJECTIVE: To assess the effects of piplartine (1) and cinnamides (2-5) against the protozoa responsible for malaria and leishmaniasis, and peritoneal cells of Swiss mice. MATERIALS AND METHODS: Cultures of Leishmania amazonensis, Plasmodium falciparum-infected erythrocytes, and peritoneal cells were incubated, in triplicate, with different concentrations of the compounds (0 to 256 μg/mL)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28407721/chemical-composition-and-biological-investigation-of-pelargonium-endlicherianum-root-extracts
#6
Gökçe Şeker Karatoprak, Fatih Göger, Mükerrem Betül Yerer, Müberra Koşar
CONTEXT: Pelargonium endlicherianum Fenzl. (Geraniaceae) roots and flowers are traditionally used in Turkey as a decoction treatment against intestinal parasites. Neither the chemical composition nor the potential bioactivity of the plant roots has been studied before. OBJECTIVES: The phenolic content and effects of P. endlicherianum root extracts on antioxidant enzyme levels on A549 cells were studied for the first time. MATERIALS AND METHODS: The chemical composition was analyzed via spectrophotometric and chromatographic (HPLC MS/MS and HPLC) techniques...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28407719/anti-inflammatory-activity-of-clove-eugenia-caryophyllata-essential-oil-in-human-dermal-fibroblasts
#7
Xuesheng Han, Tory L Parker
CONTEXT: Clove (Eugenia caryophyllata Thunb. [Myrtaceae]) essential oil (CEO) has been shown to possess antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory and anticancer properties. However, few studies have focused on its topical use. OBJECTIVE: We investigated the biological activity of a commercially available CEO in a human skin disease model. MATERIALS AND METHODS: We evaluated the effect of CEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodelling in a validated human dermal fibroblast system, which was designed to model chronic inflammation and fibrosis...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28399694/development-of-essential-oils-as-skin-permeation-enhancers-penetration-enhancement-effect-and-mechanism-of-action
#8
Qiudong Jiang, Yeming Wu, Hui Zhang, Pei Liu, Junhong Yao, Peijun Yao, Jun Chen, Jinao Duan
CONTEXT: Essential oils (EOs) have shown the potential to reversibly overcome the stratum corneum (SC) barrier to enhance the skin permeation of drugs. OBJECTIVE: The effectiveness of turpentine, Angelica, chuanxiong, Cyperus, cinnamon, and clove oils were investigated for the capacity and mechanism to promote skin penetration of ibuprofen. MATERIALS AND METHODS: Skin permeation studies of ibuprofen across rat abdominal skin with the presence of 3% w/v EOs were carried out; samples were withdrawn from the receptor compartment at 8, 10, 22, 24, 26, 28, 32, 36, and 48 h and analyzed for ibuprofen content by the HPLC method...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28398103/endophytic-fungi-associated-with-monarda-citriodora-an-aromatic-and-medicinal-plant-and-their-biocontrol-potential
#9
Meenu Katoch, Shipra Pull
CONTEXT: The Food and Agriculture Organization has estimated that every year considerable losses of the food crops occur due to plant diseases. Although fungicides are extensively used for management of plant diseases, they are expensive and hazardous to the environment and human health. Alternatively, biological control is the safe way to overcome the effects of plant diseases and to sustain agriculture. Since Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae) is known for its antifungal properties, it was chosen for the study...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28395583/isolation-and-identification-of-compounds-from-kalanchoe-pinnata-having-human-alphaherpesvirus-and-vaccinia-virus-antiviral-activity
#10
Matthew Cryer, Kyle Lane, Mary Greer, Rex Cates, Scott Burt, Merritt Andrus, Jiping Zou, Paul Rogers, Marc D H Hansen, Jillybeth Burgado, Subbian Satheshkumar Panayampalli, Craig W Day, Donald F Smee, Brent F Johnson
CONTEXT: Kalanchoe pinnata (Lam.) Pers. (Crassulaceae) is a succulent plant that is known for its traditional antivirus and antibacterial usage. OBJECTIVE: This work examines two compounds identified from the K. pinnata plant for their antivirus activity against human alphaherpesvirus (HHV) 1 and 2 and vaccinia virus (VACV). MATERIALS AND METHODS: Compounds KPB-100 and KPB-200 were isolated using HPLC and were identified using NMR and MS. Both compounds were tested in plaque reduction assay of HHV-2 wild type (WT) and VACV...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28395572/protective-effects-of-ampelopsis-brevipedunculata-against-in-vitro-hepatic-stellate-cells-system-and-thioacetamide-induced-liver-fibrosis-rat-model
#11
Mun Jeong Yum, Sushruta Koppula, Jin Seoub Kim, Gwang Mo Shin, Yun Jin Chae, Tony Yoon, Chi Su Chun, Jae Dong Lee, MinDong Song
CONTEXT: Ampelopsis brevipedunculata Maxim (Vitaceae) is a traditional medicinal herb used for treating liver disorders. OBJECTIVE: The hepatoprotective effects of A. brevipedunculata ethanol extract (ABE) was investigated in experimental models of fibrosis. MATERIALS AND METHODS: Hepatic stellate cells (HSCs) system in vitro and thioacetamide (TAA)-induced liver fibrosis rat model in vivo were used. Sprague-Dawley rats were divided into five groups of eight each (control, TAA, TAA with ABE 10 mg/kg, ABE 100 mg/kg and silymarin 50 mg/kg groups, respectively)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28385108/urtica-dioica-attenuates-ovalbumin-induced-inflammation-and-lipid-peroxidation-of-lung-tissues-in-rat-asthma-model
#12
Hanene Zemmouri, Omar Sekiou, Sonda Ammar, Abdelfattah El Feki, Mohamed Bouaziz, Mahfoud Messarah, Amel Boumendjel
CONTEXT: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use. OBJECTIVE: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract. MATERIALS AND METHODS: Adult male Wistar rats were divided into four groups: Group I: negative control; group II: Ovalbumin sensitized/challenged rats (positive control); group III: received UD extract (1...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28385098/pharmacological-evaluation-of-the-anxiolytic-like-effects-of-lippia-graveolens-and-bioactive-compounds
#13
María Eva González-Trujano, Laura Yunuen Hernández-Sánchez, Verónica Muñoz Ocotero, Alejandro Dorazco-González, Patricia Guevara Fefer, Eva Aguirre-Hernández
CONTEXT: Lippia species (Verbenaceae) are widely used in Latin America and Africa as folk medicine for their tranquilizing properties. OBJECTIVE: To evaluate the anxiolytic-like effects and safety of Lippia graveolens Kunth. by exploring its aqueous and organic leaf extracts and identifying the responsible chemical constituents. MATERIAL AND METHODS: Aqueous and organic extracts (hexane, ethyl acetate and methanol) were pharmacologically evaluated at several doses...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28385088/plants-in-our-combating-strategies-against-mycobacterium-tuberculosis-progress-made-and-obstacles-met
#14
Vivek Kumar Gupta, M Madhan Kumar, Deepa Bisht, Anupam Kaushik
CONTEXT: Traditionally used plants for treating chest-related problems/tuberculosis (TB) have not been evaluated in detail and hence a thorough study is needed in this regard. This knowledge may find application in developing new anti-TB drugs. OBJECTIVE: This article elaborates on studying the activity of medicinal plants against different forms of Mycobacterium tuberculosis (Mtb) using different model strains, in vitro and ex vivo assays for studying the tuberculocidal activity and discusses the results from different studies on the activity against different forms of Mtb and human immunodeficiency virus-tuberculosis (HIV-TB) co-infection...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28385083/anti-dhav-1-reproduction-and-immuno-regulatory-effects-of-a-flavonoid-prescription-on-duck-virus-hepatitis
#15
Yun Chen, Ling Zeng, Jingjing Yang, Yixuan Wang, Fangke Yao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu
CONTEXT: The flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) has a curative effect on duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1). However, the mechanism of this curative effect is not understood. OBJECTIVE: This study investigates the mechanism of the curative effect of BLIN on DVH caused by DHAV-1. We analyzed the anti-DHAV-1 reproduction mechanism and immuno-regulatory effect of BLIN. MATERIALS AND METHODS: The anti-DHAV-1 reproduction effects of BLIN at 20, 10, 5 and 2...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28385055/phytochemical-composition-anti-inflammatory-activity-and-cytotoxic-effects-of-essential-oils-from-three-pinus-spp
#16
Mimoza Basholli-Salihu, Roswitha Schuster, Avni Hajdari, Dafina Mulla, Helmut Viernstein, Behxhet Mustafa, Monika Mueller
CONTEXT: Inflammation and cell differentiation lead to a number of severe diseases. In the recent years, various studies focused on the anti-inflammatory and anticancer activity of essential oils (EOs) of numerous plants, including different Pinus species. OBJECTIVE: The phytochemical composition, anti-inflammatory and cytotoxic activity of EOs from needles and twigs of Pinus heldreichii Christ (Pinaceae) and P. peuce Griseb., and from needles, twigs and cones of P...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28376640/antimicrobial-activity-of-buchenavia-tetraphylla-against-candida-albicans-strains-isolated-from-vaginal-secretions
#17
José Robson Neves Cavalcanti Filho, Tiago Fonseca Silva, Woah Queiroz Nobre, Larissa Isabela Oliveira de Souza, Cristiane Santos Silva E Silva Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, Norma Buarque de Gusmão, Márcia Vanusa Silva, Luís Cláudio Nascimento da Silva, Maria Tereza Dos Santos Correia
CONTEXT: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. MATERIALS AND METHODS: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28372475/in-vivo-antitumour-potential-of-camel-s-milk-against-hepatocellular-carcinoma-in-rats-and-its-improvement-of-cisplatin-renal-side-effects
#18
Hala M F El Miniawy, Kawkab A Ahmed, Sameeh A Mansour, Marwa M Salah Khattab
CONTEXT: Camel milk (CM) is recommended for liver disease patients in Egypt for a strong belief that it has a curative effect. OBJECTIVE: The effect of consumption of CM with or without chemotherapeutic drug cisplatin was evaluated on induced hepatocarcinogenesis in rats. MATERIALS AND METHODS: Wistar male rats (56) were divided into eight groups (7 rats each). Group I was control. Hepatocarcinogenesis was initiated by a single dose of intraperitoneal injection of diethylnitrosamine (DENA) (200 mg/kg BW) and promoted by phenobarbitone (500 ppm) in drinking water in groups V, VI, VII and VIII...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28372473/selection-of-chemical-markers-for-the-quality-control-of-medicinal-plants-of-the-genus-cecropia
#19
Andrés Rivera-Mondragón, Orlando O Ortíz, Sebastiaan Bijttebier, Arnold Vlietinck, Sandra Apers, Luc Pieters, Catherina Caballero-George
CONTEXT: Several Cecropia (Cecropiaceae) species are traditionally used in Latin America for the treatment of a variety of diseases including diabetes, arterial hypertension, asthma, bronchitis, anxiety, and inflammation. At present, a number of commercial products based on these plants have been introduced into the market with very little information on methods for guaranteeing their quality and safety. OBJECTIVE: This work proposes potential chemical markers for the quality control of the raw materials of Cecropia obtusifolia Bertol...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28367666/suppression-of-vegf-induced-angiogenesis-and-tumor-growth-by-eugenia-jambolana-musa-paradisiaca-and-coccinia-indica-extracts
#20
Harsha Raj M, Debidas Ghosh, Rita Banerjee, Bharathi P Salimath
CONTEXT: Abnormal angiogenesis and evasion of apoptosis are hallmarks of cancer. Accordingly, anti-angiogenic and pro-apoptotic therapies are effective strategies for cancer treatment. Medicinal plants, namely, Eugenia jambolana Lam. (Myrtaceae), Musa paradisiaca L. (Musaceae), and Coccinia indica Wight & Arn. (Cucurbitaceae), have not been greatly investigated for their anticancer potential. OBJECTIVE: We investigated the anti-angiogenic and pro-apoptotic efficacy of ethyl acetate (EA) and n-butanol (NB) extracts of E...
December 2017: Pharmaceutical Biology
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