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Pharmaceutical Biology

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https://www.readbyqxmd.com/read/28508681/correction-to-abhishek-et%C3%A2-al-antioxidant-and-anti-inflammatory-activities-of-aerva-pseudotomentosa-leaves
#1
(no author information available yet)
No abstract text is available yet for this article.
May 16, 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28466672/corrigendum
#2
(no author information available yet)
No abstract text is available yet for this article.
May 3, 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28633584/variation-of-alkaloid-contents-and-antimicrobial-activities-of-papaver-rhoeas-l-growing-in-turkey-and-northern-cyprus
#3
İlkcan Çoban, Gizem Gülsoy Toplan, Berna Özbek, Çağlayan Unsal Gürer, Günay Sarıyar
CONTEXT: Papaver rhoeas L. (Papaveraceae) corn poppy, widely distributed in Turkey, is used to make a cough syrup for children, as a tea for disturbed sleep, for pain relief and as a sedative in folk medicine. OBJECTIVE: Samples of P. rhoeas collected from eight different locations in Turkey and three from northern Cyprus were investigated for their alkaloid content and screened for their antimicrobial activities. MATERIALS AND METHODS: From the aerial parts of P...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#4
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28629287/anti-acetylcholinesterase-activity-and-antioxidant-properties-of-extracts-and-fractions-of-carpolobia-lutea
#5
Lucky Legbosi Nwidu, Ekramy Elmorsy, Jack Thornton, Buddhika Wijamunige, Anusha Wijesekara, Rebecca Tarbox, Averil Warren, Wayne Grant Carter
CONTEXT: There is an unmet need to discover new treatments for Alzheimer's disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae). OBJECTIVE: The objective of this study is to quantify C. lutea anti-AChE, DPPH free radical scavenging, and antioxidant activities and cell cytotoxicity. MATERIALS AND METHODS: Plant stem, leaves and roots were subjected to sequential solvent extractions, and screened for anti-AChE activity across a concentration range of 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28614988/in-vitro-inhibitory-effects-of-dihydromyricetin-on-human-liver-cytochrome-p450-enzymes
#6
Lu Liu, Sen Sun, Hongbing Rui, Xiaohua Li
CONTEXT: Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. MATERIALS AND METHODS: The inhibitory effects of DHM on eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19 and 2C8) were investigated in vitro using human liver microsomes (HLMs)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28614972/anti-inflammatory-effects-of-a-traditional-korean-medicine-ojayeonjonghwan
#7
Sun-Young Nam, Kyu-Yeob Kim, Mi Hye Kim, Jae-Bum Jang, So-Young Rah, Hee Jeong Chae, Jin-Man Lee, Hyung-Min Kim, Hyun-Ja Jeong
OBJECTIVE: To study the anti-inflammatory properties of OJ. CONTEXT: Ojayeonjonghwan (OJ) is a traditional Korean prescription, which has been widely used for the treatment of prostatitis. However, no scientific study has been performed of the anti-inflammatory effects of OJ. MATERIALS AND METHODS: Peritoneal macrophages were isolated 3-4 days after injecting a C57BL/6J mouse with thioglycollate. They were then treated with OJ water extract (0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28614959/the-effects-of-triptolide-on-the-pharmacokinetics-of-sorafenib-in-rats-and-its-potential-mechanism
#8
Xianming Wang, Xin Zhang, Fei Liu, Minghai Wang, Shiyong Qin
CONTEXT: Combining sorafenib with triptolide could inhibit tumour growth with greater efficacy than single-agent treatment. However, their herb-drug interaction remains unknown. OBJECTIVE: This study investigates the herb-drug interaction between triptolide and sorafenib. MATERIALS AND METHODS: The effects of triptolide (10 mg/kg) on the pharmacokinetics of different doses of sorafenib (20, 50 and 100 mg/kg) in rats, and blood samples were collected within 48 h and evaluated using LC-MS/MS...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28571528/antioxidant-activity-against-h2o2-induced-cytotoxicity-of-the-ethanol-extract-and-compounds-from-pyrola-decorate-leaves
#9
Xiliang Yang, Qingyun Peng, Qian Liu, Jie Hu, Zhipeng Tang, Lianjie Cui, Zonghao Lin, Bing Xu, Kuojian Lu, Fang Yang, Zhizheng Sheng, Qiong Yuan, Song Liu, Jiuliang Zhang, Xuefeng Zhou
CONTEXT: The leaves of Pyrola decorate H. Andr (Pyrolaceae), known as Luxiancao, have long been used for treating kidney deficiency, gastric haemorrhage and rheumatic arthritic diseases in traditional Chinese medicine. OBJECTIVE: The phytochemicals and antioxidant capacities in vitro of P. decorate leaves were investigated. MATERIALS AND METHODS: Ethanol, petroleum ether, acetidin, n-butyl alcohol and aqueous extracts of Pyrola decorate leaves were prepared by solvent sequential process, and then isolated and purified to obtain phytochemicals...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28571499/amelioration-of-hyperglycaemia-and-modulation-of-antioxidant-status-by-alcea-rosea-seeds-in-alloxan-induced-diabetic-rats
#10
Parvaiz A Dar, Fasil Ali, Ishfaq A Sheikh, Showkat A Ganie, Tanveer A Dar
CONTEXT: Alcea rosea L. (Malvaceae) has various medicinal uses including anticancer, anti-inflammatory and analgesic properties. However, there is no report on its antidiabetic activity. OBJECTIVE: Alcea rosea seed extracts were evaluated for antihyperglycaemic and antioxidative potential in diabetic rats. MATERIALS AND METHODS: Single intra-peritoneal injection of alloxan (130 mg/kg b.w.) was used for induction of diabetes in Albino Wistar rats...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28552036/in-vitro-evaluation-of-spirulina-platensis-extract-incorporated-skin-cream-with-its-wound-healing-and-antioxidant-activities
#11
Seda Gunes, Sedef Tamburaci, Meltem Conk Dalay, Ismet Deliloglu Gurhan
CONTEXT: Algae have gained importance in cosmeceutical product development due to their beneficial effects on skin health and therapeutical value with bioactive compounds. Spirulina platensis Parachas (Phormidiaceae) is renowned as a potential source of high-value chemicals and recently used in skincare products. OBJECTIVE: This study develops and evaluates skin creams incorporated with bioactive S. platensis extract. MATERIALS AND METHODS: Spirulina platensis was cultivated, the aqueous crude extract was prepared and in vitro cytotoxicity of S...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28552029/a-standardized-hippophae-extract-sbl-1-counters-neuronal-tissue-injuries-and-changes-in-neurotransmitters-implications-in-radiation-protection
#12
Madhu Bala, Vanita Gupta, Jagdish Prasad
CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. Understanding CTA in rats is important because its process is considered parallel to nausea and vomiting in humans. OBJECTIVE: This study investigated the levels of neurotransmitters, antioxidant defences and histological changes in rats showing radiation CTA, and their modification by SBL-1...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28545346/gamma-linolenic-acid-ameliorated-glycation-induced-memory-impairment-in-rats
#13
Shahab Ali Khan, Ali Haider, Wajahat Mahmood, Talat Roome, Ghulam Abbas
CONTEXT: γ-Linolenic acid (GLA) is an important constituent of anti-ageing supplements. OBJECTIVE: The current study investigates the anti-ageing effect of GLA in Sprague-Dawley rats. MATERIALS AND METHODS: GLA (0.1, 0.2, 0.4, 2, 10, 20 and 24 μM) was initially evaluated for its effect on the formation of advanced glycation end products (AGEs) in vitro. For in vivo assessment (1, 5 or 15 mg/kg), the rat model of accelerated ageing was developed using d-fructose (1000 mg/kg (i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28545313/effects-of-rosmarinic-acid-on-acetaminophen-induced-hepatotoxicity-in-male-wistar-rats
#14
Parisa Hasanein, Maryam Sharifi
CONTEXT: Drug-induced liver injury is a significant worldwide clinical problem. Rosmarinic acid (RA), a natural phenol, has antioxidant effects. OBJECTIVE: The effects of RA against acetaminophen (N-acetyl-p-amino-phenol (APAP))-induced oxidative damage and hepatotoxicity in rats were investigated. MATERIALS AND METHODS: Male Wistar rats were pretreated with RA (10, 50 and 100 mg/kg, i.g.) for one week. On day 7, rats received APAP (500 mg/kg, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28539068/ethanol-extract-and-chromatographic-fractions-of-tamarindus-indica-stem-bark-inhibits-newcastle-disease-virus-replication
#15
Omobola O Okoh, Grace E Obiiyeke, Uchechukwu U Nwodo, Anthony I Okoh
CONTEXT: The plethora of ethnomedicinal applications of Tamarindus indica Linn. (Leguminosae), tamarind, includes treatment of human and livestock ailments; preparations are recognized antipyretics in fevers, laxatives and carminatives. African folklore has various applications of tamarind. However, in Nyasaland, domestic fowl are fed with preparations for prophylactic properties. OBJECTIVES: The objective of this study is to evaluate the antiviral properties of T...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28534695/wound-healing-activity-of-pluchea-indica-leaf-extract-in-oral-mucosal-cell-line-and-oral-spray-formulation-containing-nanoparticles-of-the-extract
#16
Wiphupat Buranasukhon, Sirivan Athikomkulchai, Sarin Tadtong, Chuda Chittasupho
CONTEXT: Pluchea indica (L.) Less (Asteraceae) is an herb used as a traditional medicine for wound healing. The chemical compounds found in Pluchea indica leaves are phenolic acids, flavonoids, anthocyanins and carotenoids. OBJECTIVE: This study investigates the effect of Pluchea indica leaf ethanol extract and its nanoparticles (NPs) on cytotoxicity, cell survival and migration of human oral squamous carcinoma cell line. MATERIALS AND METHODS: Cell viability was measured using MTT assay to assess the effect of Pluchea indica leaf extract and NPs (1-500 μg/mL) on cytotoxicity and cell survival...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28532232/a-two-week-double-blind-placebo-controlled-trial-of-viola-odorata-echium-amoenum-and-physalis-alkekengi-mixture-in-symptomatic-benign-prostate-hyperplasia-bph-men
#17
Fatemeh Beiraghdar, Behzad Einollahi, Alireza Ghadyani, Yunes Panahi, Abbas Hadjiakhoondi, Mahdi Vazirian, Ali Salarytabar, Behrad Darvishi
CONTEXT: As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet. OBJECTIVE: This study evaluates the therapeutical effects of V...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28532227/peptides-extracted-from-edible-mushroom-lentinus-squarrosulus-induces-apoptosis-in-human-lung-cancer-cells
#18
Arisara Prateep, Somruethai Sumkhemthong, Maneewan Suksomtip, Pithi Chanvorachote, Chatchai Chaotham
CONTEXT: Lentinus squarrosulus Mont. (Polyporaceae) is an interesting source of diverse bioactive compounds. OBJECTIVE: This is the first study of the anticancer activity and underlying mechanism of peptides extracted from Lentinus squarrosuls. MATERIALS AND METHODS: Peptides were isolated from the aqueous extract of L. squarrosulus by employing solid ammonium sulphate precipitation. They were further purified by ion-exchange chromatography on diethylaminoethanol (DEAE)-cellulose and gel filtration chromatography on Sephadex G25...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#19
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524742/piqueria-trinervia-as-a-source-of-metabolites-against-giardia-intestinalis
#20
Yadira Rufino-González, Martha Ponce-Macotela, Manuel Jiménez-Estrada, Candy N Jiménez-Fragoso, Guadalupe Palencia, Gabriel Sansón-Romero, Anahi Anzo-Osorio, Mario N Martínez-Gordillo
CONTEXT: Piqueria trinervia Cav. (Asteraceae) is a plant species with a long history in traditional medicine to cure diarrhoea and other digestive disorders. OBJECTIVE: The study investigates the antigiardial activity of piquerol, trinervinol, red oil and two fractions (F1 and F2) from P. trinervia. MATERIALS AND METHODS: P. trinervia was collected in the Ajusco in Mexico City. Aerial parts were ground and mixed with water to obtain the extract, which was treated with dichloromethane to isolate piquerol and trinervinol (P & T)...
December 2017: Pharmaceutical Biology
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