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Journal of Medicinal Food

Md Mohibbullah, Jae-Suk Choi, Mohammad Maqueshudul Haque Bhuiyan, Md Nazmul Haque, Md Khalilur Rahman, Il Soo Moon, Yong-Ki Hong
Exogenous neurotrophins can induce neuronal differentiation, outgrowth, survival, and synaptic function in the central nervous system. In primary cultures of rat hippocampal neurons, an ethanol extract of the red alga Gracilariopsis chorda (GCE) and its active compound arachidonic acid (AA) significantly increased the densities of dendritic filopodia and spines, promoted the expression of presynaptic vesicle protein 2 (SV2) and postsynaptic density protein 95 (PSD-95), induced robust synaptogenesis, and increased the expression of cell division control protein 42 (CDC42) and actin-related protein 2 (ARP2), which are important for actin organization in dendritic protrusions, and facilitated presynaptic plasticity by increasing the size of the synaptic vesicle pool at presynaptic nerve terminals...
March 2, 2018: Journal of Medicinal Food
Glauber Cruz Lima, Yuri de Abreu Gomes Vasconcelos, Marilia Trindade de Santana Souza, Alan Santos Oliveira, Rangel Rodrigues Bomfim, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Enilton Aparecido Camargo, Viviane Gomes Portella, Andrelina Noronha Coelho-de-Souza, Lúcio Ricardo Leite Diniz
No specific therapeutics are available for the treatment of sepsis-induced liver dysfunction, a clinical complication strongly associated with the high mortality rate of septic patients. This study investigated the effect of the essential oil of Hyptis crenata (EOHc), a lamiaceae plant used to treat liver disturbances in Brazilian folk medicine, on liver function during early sepsis. Sepsis was induced by the cecal ligation and puncture (CLP) model. Rats were divided into four groups: Sham, Sham+EOHc, CLP, and CLP+EOHc...
February 28, 2018: Journal of Medicinal Food
Kais Rtibi, Slimen Selmi, Dhekra Grami, Mohamed Amri, Hichem Sebai, Lamjed Marzouki
The phytochemical composition and the effect of the green and ripe Opuntia ficus-indica juice on some gastrointestinal (GI) physiological parameters such as stomach emptying and small-intestinal motility and permeability were determined in rats administered multiple concentrations of the prickly pear juice (5, 10, and 20 mL kg-1 , b.w., p.o.). Other separate groups of rats were received, respectively; sodium chloride (0.9%, b.w., p.o.), clonidine (α-2 -adrenergic agonist, 1 mg kg-1 , b.w., i.p.), yohimbine (α-2 -adrenergic antagonist, 2 mg kg-1 , b...
February 28, 2018: Journal of Medicinal Food
Jeremy E Davis, Darcie Hastings
Adipogenesis is central to adipose tissue plasticity and lipid homeostasis. Regulation of adipogenic signaling by phytoestrogens has been implicated as a potential therapeutic strategy for obesity-related disease. However, it remains unclear how these compounds directly impact transcriptional control of adipogenesis. As such, the focus of this study was to determine how daidzein and genistein effect transcriptional activation of peroxisome proliferator-activated receptor gamma (PPARγ) and TCF/LEF in 3T3-L1 preadipocytes...
February 27, 2018: Journal of Medicinal Food
Young Mi Cho, Jeong Eun Kwon, Minkyung Lee, Youngsung Lea, Do-Yong Jeon, Hyeong Jun Kim, Se Chan Kang
Agrimonia eupatoria L. has been shown to protect against liver injury due to its lipid lowering and antioxidant activities. The aim of this research was to evaluate the effect of A. eupatoria L. aqueous extract (AEE) on 80 subjects with elevated alanine transaminase (ALT) levels in a randomized, double-blind, placebo-controlled, 8-week study. This trial was conducted between January 2013 and July 2013 at the Oriental Medical Hospital (Jecheon) of Semyung University. The trial included subjects aged 20 years or older who were diagnosed with mildly to moderately elevated ALT levels (between 45 and 135 IU/L)...
February 27, 2018: Journal of Medicinal Food
Lilian Dolores Chel-Guerrero, Enrique Sauri-Duch, Mabel Clara Fragoso-Serrano, Laura Josefina Pérez-Flores, José Luis Gómez-Olivares, Noé Salinas-Arreortua, Edgar Del Carmen Sierra-Palacios, José Alberto Mendoza-Espinoza
Tropical fruit peels are generally discarded as waste, yet they contain bioactive substances that could have various uses; in addition, their pharmacological potential remains unexplored. This study aims to characterize the phytochemical profile, toxicity, and pharmacological potential of methanol extracts obtained from the peels of the following tropical fruit species: Annona squamosa L. (purple sugar apple), Annona reticulata L. (custard apple), Chrysophyllum cainito L. (green star apple), and Melicoccus bijugatus Jacq...
February 26, 2018: Journal of Medicinal Food
Serim Kim, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200 mg·kg bw-1 ·day-1 , n = 10) or distilled water (Control group, n = 10) for 8 weeks...
February 23, 2018: Journal of Medicinal Food
Sun Hee Hong, Minji Woo, Mijeong Kim, Yeong Ok Song
We have previously reported the lipid-lowering effects of a Korean rice cookie called dasik (RCD) in comparison with a western style cookie. In this study, Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) fruit-supplemented RCD (SRCD) was added to a diet, and the hypolipidemic and antidiabetic effects of different diets were examined by using the ICR and db/db mouse models, respectively. ICR mice were fed the AIN-76 diet, or high-fat diet (HFD), or the RCD- or SRCD-supplemented HFD (10%, w/w) for 9 weeks (n = 7 per group)...
February 23, 2018: Journal of Medicinal Food
Yong-Deok Jeon, Sa-Haeng Kang, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Jong-Sung Kim, Byung-Yong Ahn, Jong-Sik Jin
The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe...
February 22, 2018: Journal of Medicinal Food
Wilman Carrillo, Karin Maia Monteiro, Humberto Spindola, Mercedes Ramos, João Ernesto de Carvalho
The aim of this study was to evaluate the antiulcerative and antinociceptive activities of milk proteins using the induced gastric ulcer with ethanol rat model and the acetic acid-induced writhing mouse model. Casein (CN), (100, 300, and 1000 mg kg-1 ) doses presented antiulcerative activity on a dose-dependent manner with values of 30.8%, 41.4%, and 57.0% of inhibition measured using the ulcerative lesions index (ULI), respectively. Whey protein concentrate (WPC), (100, 300, and 1000 mg kg-1 ) doses presented antiulcerative activity on a dose-dependent manner with values of 48...
February 21, 2018: Journal of Medicinal Food
Kumju Youn, Ji-Hyun Park, Seonah Lee, Seungeun Lee, Jinhyuk Lee, Eun-Young Yun, Woo-Sik Jeong, Mira Jun
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a role in generating amyloid β (Aβ), thus playing a major part early in the pathogenesis of Alzheimer's disease (AD). BACE1 has emerged as a crucial therapeutic target for decreasing the Aβ concentration in the AD brain. To explore natural BACE1 inhibitors, the present study concentrated on isoflavones, including genistein, formononetin, glycitein, daidzein, and puerarin. In this study, in vitro anti-AD activities were assessed using BACE1 inhibition assays, as well as enzyme kinetic predictions...
February 14, 2018: Journal of Medicinal Food
Tiago Felipe Senes-Lopes, Jorge Alberto López, Viviane Souza do Amaral, José Brandão-Neto, Adriana Augusto de Rezende, Jefferson Romáryo Duarte da Luz, Zaira da Rosa Guterres, Maria das Graças Almeida
Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5...
February 13, 2018: Journal of Medicinal Food
Anaelechi J Onuegbu, Japhet M Olisekodiaka, Sylvia E Irogue, Ubuo K Amah, John E Okwara, Olubunmi G Ayelagbe, Christian E Onah
Consumption of soy products is speculated to reduce the risk and progression of some disease conditions. The underlying mechanisms mediating this effect are uncertain, but the lowering of oxidative stress has been suggested. This study was aimed at investigating the effect of soymilk on antioxidant status and lipid peroxidation in apparently healthy individuals. Five hundred milliliters of soymilk was taken daily by each of 39 apparently healthy individuals for a period of 28 days. Two sets of blood samples (baseline and after 28 days of soymilk intake) were collected and assayed for total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione S-transferase (GST), manganese (Mn) and zinc (Zn) levels, using standard methods...
February 12, 2018: Journal of Medicinal Food
Bingna Cai, Peng Wan, Huili Sun, Deke Chen, Hua Chen, Xin Chen, Jianyu Pan
Chemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30-60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0...
February 12, 2018: Journal of Medicinal Food
Marisol Cortez-Navarrete, Esperanza Martínez-Abundis, Karina G Pérez-Rubio, Manuel González-Ortiz, Miriam Méndez-Del Villar
An improvement in parameters of glycemic control has been observed with Momordica charantia in patients with type 2 diabetes mellitus (T2DM). It is unknown whether this improvement is through a modification of insulin secretion, insulin sensitivity, or both. We hypothesized that M. charantia administration can improve insulin secretion and/or insulin sensitivity in patients with T2DM, without pharmacological treatment. The objective of the study was to evaluate the effect of M. charantia administration on insulin secretion and sensitivity...
February 12, 2018: Journal of Medicinal Food
Elsa Brito, André Silva, Pedro Luis Vieira Falé, Rita Pacheco, António Serralheiro, Parvez I Haris, Lia Ascensão, Maria Luísa Serralheiro
Rosmarinic acid (RA) is a phenolic compound with biological activity. The objective of the present study was to investigate whether this compound kept its biological activity in the presence of proteins. For this purpose, bovine serum albumin (BSA) was used as a model protein, and the capacity of the RA to inhibit acetylcholinesterase (AChE) and affect antioxidant activity was evaluated in the absence and presence of BSA. A mixture of phenolic compounds containing RA, obtained from a medicinal plant was added to this study...
February 12, 2018: Journal of Medicinal Food
Yung Sing Ch'ng, Yean Chun Loh, Chu Shan Tan, Mariam Ahmad, Mohd Zaini Asmawi, Wan Maznah Wan Omar, Mun Fei Yam
The seeds of Swietenia macrophylla King (SM) (Meliaceae) are used as a folk medicine for the treatment of hypertension in Malaysia. However, the antihypertensive and vasorelaxant effects of SM seeds are still not widely studied. Thus, this study was designed to investigate the in vivo antihypertensive effects and in vitro mechanism of vasorelaxation of a 50% ethanolic SM seed extract (SM50) and the fingerprint of SM50 was developed through tri-step Fourier transform infrared (FTIR) spectroscopy. The vasorelaxant activity and the underlying mechanisms of SM50 were evaluated on thoracic aortic rings isolated from Sprague-Dawley rats in the presence of antagonists...
February 8, 2018: Journal of Medicinal Food
Un Ju Jung, Sang Ryong Kim
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta and decreases in striatal dopamine levels. These changes led to several clinical symptoms: rigidity, resting tremor, and bradykinesia. Although the cause of PD remains unclear, it is widely accepted that oxidative stress, neuroinflammation, mitochondrial dysfunction, and insufficient support of neurotrophic factors are involved in the pathophysiology of the disease. However, novel regimens to prevent neurodegeneration and restore the degenerated nigrostriatal DA system are still required...
February 7, 2018: Journal of Medicinal Food
Michael Rohr, Chandrakala Aluganti Narasimhulu, Dhara Sharma, Mitsushita Doomra, Aladdin Riad, Saleh Naser, Sampath Parthasarathy
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract whose prevalence has been dramatically increasing over the past decade. New studies have shown that IBD is the second most common chronic inflammatory disease worldwide after rheumatoid arthritis, affecting millions of people mainly in industrialized countries. Symptoms of IBD include frequent bloody diarrhea, abdominal cramping, anorexia, abdominal distension, and emesis...
February 1, 2018: Journal of Medicinal Food
Seul Ah Lee, Sung-Min Moon, Seul Hee Han, Eun Ju Hwang, Joon Ho Hong, Bo-Ram Park, Mi Suk Choi, Hoon Ahn, Jae-Sung Kim, Heung-Joong Kim, Hong Sung Chun, Do Kyung Kim, Chun Sung Kim
Anthriscus sylvestris (L.) Hoffm. is a common perennial herb that is widely distributed in Europe, Korea, and New Zealand. The root of A. sylvestris has been used in Korean traditional medicine as an antitussive and cough remedy. However, the physiologically active function of A. sylvestris leaves is not yet known. In this study, we evaluated the anti-inflammatory effects, as well as the underlying molecular mechanisms of an aqueous extract of A. sylvestris leaves (AE-ASL) in vitro and in vivo. Our results indicated that pretreatment with AE-ASL significantly inhibited the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO) and prostaglandin E2 in RAW264...
January 29, 2018: Journal of Medicinal Food
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