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Journal of Medicinal Food

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https://www.readbyqxmd.com/read/27898282/comparative-fingerprinting-of-the-human-microbiota-in-diabetes-and-cardiovascular-disease
#1
Emanuel Vamanu, Diana Pelinescu, Ionela Sarbu
Diabetes and cardiovascular diseases are major causes of morbidity and mortality worldwide, and are associated with changes in the human gut microbiota. To better understand the relationships between diet, disease, and the colonic microbiome, we used the in vitro GIS1 system and repetitive element palindromic polymerase chain reaction (rep-PCR) to determine the microbial fingerprints in individuals with these diseases and compared them with the fingerprints in healthy controls. Clear differences were apparent in the three groups...
November 29, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27893308/evaluation-of-hypotensive-and-antihypertensive-effects-of-velvet-bean-mucuna-pruriens-l-hydrolysates
#2
Luis Chel-Guerrero, Saulo Galicia-Martínez, Juan José Acevedo-Fernández, Jesus Santaolalla-Tapia, David Betancur-Ancona
Hypertension could cause significant worldwide health problems that affect 15-20% of all adults; according to National Health and Nutrition Examination Survey, about 29% of the adult population in the United States are hypertensive. Recent research has shown that peptides derived from the hydrolysis of food proteins can decrease blood pressure. This study was carried out to evaluate the hypotensive and antihypertensive potential of Mucuna pruriens protein hydrolysates in in vitro and in vivo models. M. pruriens protein concentrate was prepared by wet fractionation and enzymatically hydrolyzed using Alcalase(®), Flavourzyme(®), and the sequential system Alcalase-Flavourzyme at different times (5-120 min)...
November 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27875657/characterization-of-macrophage-activating-polysaccharide-isolated-from-fermented-brown-rice
#3
Dae-Young Lee, Myoung-Sook Shin, Kwang-Soon Shin
Brown rice has nutritional benefits due to its abundant nutrients and high dietary fiber content. However, it is often consumed in a fermented form for improved chewy texture and digestibility. In this study, a polysaccharide, FBR-4a, was isolated from fermented brown rice and its chemical composition was analyzed. In addition, its immune-stimulating activity was determined using RAW264.7 cells. FBR-4a is a carbohydrate and consists of nine types of monosaccharides, including galactose, arabinose, rhamnose, mannose, fucose, xylose, glucose, galacturonic acid, and glucuronic acid...
November 22, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27854151/essential-oils-from-thyme-thymus-vulgaris-chemical-composition-and-biological-effects-in-mouse-model
#4
Vaclav Vetvicka, Jana Vetvickova
Thymus species are popular spices and contain volatile oils as main chemical constituents. Recently, plant-derived essential oils are gaining significant attention due to their significant biological activities. Seven different thymus-derived essential oils were compared in our study. First, we focused on their chemical composition, which was followed up by testing their effects on phagocytosis, cytokine production, chemotaxis, edema inhibition, and liver protection. We found limited biological activities among tested oils, with no correlation between composition and biological effects...
November 17, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27828718/5-7-dimethoxyflavone-attenuates-obesity-by-inhibiting-adipogenesis-in-3t3-l1-adipocytes-and-high-fat-diet-induced-obese-c57bl-6j-mice
#5
Youngwoo Song, Mi-Bo Kim, Changhee Kim, Jongwook Kim, Jae-Kwan Hwang
The antiobesity effect of 5,7-dimethoxyflavone (DMF) was evaluated in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese C57BL/6J mice. The accumulation of lipid droplets and triglycerides in adipocytes was dose dependently suppressed by DMF through inhibition of adipogenesis. DMF downregulated the adipogenic transcription factors (peroxisome proliferator-activated receptor [PPAR]γ, CCAAT/enhancer binding protein [C/EBP]α, and sterol regulatory element-binding protein-1c [SREBP-1c]) and lipid synthesis enzymes (fatty acid synthase [FAS], acetyl-CoA carboxylase [ACC], lipoprotein lipase [LPL], and HMG-CoA reductase [HMGR])...
November 9, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27809637/anthocyanin-rich-black-soybean-testa-improved-visceral-fat-and-plasma-lipid-profiles-in-overweight-obese-korean-adults-a-randomized-controlled-trial
#6
Myoungsook Lee, Sungbin Richard Sorn, Yongsoon Park, Hoon-Ki Park
Anthocyanin-rich black soybeans have been used in traditional East Asian medicine to cure diseases related to oxidative stress and carcinogens, but not obesity. Our objective was to investigate the effects of anthocyanin-rich black soybean testa extracts (BBT), Glycine max (Chongja No. 3), on obesity. In total, 63 participants defined as overweight or obese by their body mass index (BMI >23) or waist circumference (WC >90 cm for males, >85 cm for females) were sorted into two groups: 32 receiving the trial medication (BBT, 2...
November 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27792464/fermented-platycodon-grandiflorum-extract-inhibits-lipid-accumulation-in-3t3-l1-adipocytes-and-high-fat-diet-induced-obese-mice
#7
Yu-Hua Huang, Da-Woon Jung, Ok-Hwan Lee, Il-Jun Kang
The aim of this study was to investigate whether fermented Platycodon grandiflorum (FPG) inhibits lipid accumulation in 3T3-L1 adipocytes and mice with high-fat diet (HFD)-induced obesity. We evaluated the effect of FPG on antiadipogenic activity via regulation of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), as well as protein expression of their target genes, fatty acid binding protein 4 (FABP4). We further examined the antiobesity effects of FPG on HFD-induced obesity in mice...
October 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27792456/antimicrobial-activity-and-chemical-composition-of-three-essential-oils-extracted-from-mediterranean-aromatic-plants
#8
Hazem S Elshafie, Shimaa Sakr, Stefania M Mang, Sandra Belviso, Vincenzo De Feo, Ippolito Camele
There is a growing interest in essential oils (EOs) as possible alternatives for traditional chemical pesticides. This study was carried out to characterize the chemical composition of the three EOs extracted from Verbena officinalis, Majorana hortensis, and Salvia officinalis using gas chromatography (GC) and GC-mass spectrometry (GC-MS) and to evaluate in vitro their efficacy against some phyto or human pathogens. The antifungal activity was investigated against Colletotrichum acutatum and Botrytis cinerea in comparison with Azoxystrobin as a large spectrum fungicide...
October 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27779898/reflections-about-inflammatory-bowel-disease-and-vitamins-a-and-d
#9
Sandra Maria Barbalho, Marcelo Dib Bechara, Ricardo de Alvares Goulart, Karina Quesada, Rodrigo Galhardi Gasparini, Antonely de Cássio Alves de Carvalho, Adriana Maria Ragassi Fiorini
Ulcerative colitis and Crohn's disease are two major forms of the inflammatory bowel diseases (IBDs). Vitamin A (VA) and vitamin D (VD) may be associated with reduction in inflammation in these disorders. The aim of this review was to show the current evidence that may associate VA and VD with IBDs. Data linking VA, VD, and IBDs were studied. Both VA and VD may be related to the immune system in different manners. The active form of VA, retinoic acid, may be related to the growth factor-β and release of interleukin-10 (IL-10), thus involved with the resolution of the inflammation...
October 25, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27779894/influence-of-sulforaphane-metabolites-on-activities-of-human-drug-metabolizing-cytochrome-p450-and-determination-of-sulforaphane-in-human-liver-cells
#10
Alena Vanduchova, Veronika Tomankova, Pavel Anzenbacher, Eva Anzenbacherova
The influence of metabolites of sulforaphane, natural compounds present in broccoli (Brassica oleracea var. botrytis italica) and in other cruciferous vegetables, on drug-metabolizing cytochrome P450 (CYP) enzymes in human liver microsomes and possible entry of sulforaphane into human hepatic cells were investigated. Metabolites studied are compounds derived from sulforaphane by the mercapturic acid pathway (conjugation with glutathione and by following reactions), namely sulforaphane glutathione and sulforaphane cysteine conjugates and sulforaphane-N-acetylcysteine...
October 25, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27754766/the-effects-of-different-high-protein-low-carbohydrates-proprietary-foods-on-blood-sugar-in-healthy-subjects
#11
Alessandra Lodi, Bettina Karsten, Gerardo Bosco, Manuel Gómez-López, Paula Paraguassú Brandão, Antonino Bianco, Antonio Paoli
: The aim of this study was to analyze the effects on blood sugar concentrations through the calculation of the glycemic score (GS) of 10 different high-protein low-carbohydrates (CHOs) proprietary foods that are commonly used as meals during very low-CHO ketogenic diets or during low-CHO diets. Fourteen healthy females were tested for their glycemic response curve elicited by 1000 kJ of glucose three times within a 3-week period (one test each week) compared with one of 10 test foods once on separate days twice a week...
October 18, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27705068/antiobesity-effects-of-salvia-plebeia-r-br-extract-in-high-fat-diet-induced-obese-mice
#12
Soo-Im Choi, In-Hee Cho, Se Hee Han, Yoon-Jung Jeon, Jong-Gil Choi, Jin-Sun Kim, Je-Hyuk Lee
This study was designed to investigate the antiobesity effects of Salvia plebeia R. Br. ethanolic extracts (SPE) in mice fed high-fat diets (HFD). Male C57BL/6J mice were randomly assigned to four groups: normal diet (Chow), high-fat diet (HFD, 45% fat), HFD+SPE 200 (200 mg/kg b.w.), and HFD+SPE 400 (400 mg/kg b.w.). Extracts were administered orally every day for 8 weeks. Increases in body/fat weight and feed efficiency ratio were monitored in all mice. In addition, obesity resulting from feeding HFD to the mice was confirmed by the increase of glucose level, aspartate transaminase, alanine transaminase, triglyceride (TG), high-density lipoprotein cholesterol, very low-density lipoprotein-c, leptin, and adiponectin in blood...
October 5, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27696957/effect-of-ethanol-extract-of-canavalia-gladiata-on-endurance-swimming-capacity-in-mice
#13
Beomjeong Kim, Jeongjin Park, Ho-Geun Yoon, Kyung-Chul Choi, Kyungmi Kim, Jeongmin Lee, Jin Woong Chung, Sangin Shim, Yanghee You, Woojin Jun
The effects of Canavalia gladiata ethanolic extract on endurance swimming capacity were evaluated in a mouse model. The mice were orally administered distilled water (CON), hot water extract (CGW), or 80% ethanol extract (CGE). The swimming time to exhaustion was significantly prolonged in the CGE group. Of the three groups, the CGE showed the lowest blood lactate and the highest nonesterified fatty acid and muscle glycogen levels. These results suggest that the administration of CGE could improve endurance swimming capacity by enhancing lipid catabolism and thereby preserving glycogen stores...
October 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27696939/are-dietary-patterns-associated-with-depression-in-u-s-adults
#14
Woo Kyoung Kim, Dayeon Shin, Won O Song
Nutrition is one of the most important modifiable determinants for and consequences of both mental and physical heath. Depression has become an increasingly important public health issue. We tested whether dietary patterns derived from food group intake are associated with depression in U.S. adults in a cross-sectional study with national population. This study included 4180 men and 4196 women aged 20-79 years in the 2007-2010 National Health and Nutrition Examination Surveys (NHANES), with complete data of one 24-h dietary recall, sociodemographics, lifestyles, and Patient Health Questionnaires (PHQ-9) for screening depression...
October 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27696934/effects-of-vegetable-oils-with-different-fatty-acid-compositions-on-cognition-and-memory-ability-in-a%C3%AE-25-35-induced-alzheimer-s-disease-mouse-model
#15
Ah Young Lee, Ji Myung Choi, Jaemin Lee, Myoung Hee Lee, Sanghyun Lee, Eun Ju Cho
In this study, we aimed to investigate the protective effect of three kinds of vegetable oils with different fatty acid compositions against cognitive impairment in an Alzheimer's disease (AD) mouse model. After intracerebroventricular injection of amyloid beta25-35 (Aβ25-35) into the brain of institute of cancer research mice, olive oil (rich in oleic acid, C18:1), corn oil (rich in linoleic acid, C18:2), and perilla oil (rich in α-linolenic acid [ALA], C18:3) were administered at the oral dose of 500 mg/kg/day for 14 days...
October 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27689410/the-effects-of-costaria-costata-extracts-on-atopic-dermatitis-in-an-in-vitro-model
#16
Ok-Kyung Kim, Da-Eun Nam, Minhee Lee, Han Ol Kwon, Jeongjin Park, Yanghee You, Su-Il Kim, Jeongmin Lee, Woojin Jun
We have provided a protocol for establishing an atopic dermatitis (AD) in vitro model, and evaluated the effects of Costaria costata (CC) extracts on AD in an in vitro model using keratinocytes and splenocytes from AD-induced mice and mast cells. HaCaT cells were each treated with 200 μg/mL of CC water extract (CCW), CC 10% ethanol extract (CCE10%), and CC 70% ethanol extract (CCE70%), immediately followed by stimulation with 20 ng/mL tumor necrosis factor (TNF)-α, and 20 ng/mL interferon (IFN)-γ for inflammation...
September 30, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27681299/anti-inflammatory-and-anti-nociceptive-activities-of-native-and-modified-hen-egg-white-lysozyme
#17
Wilman Carrillo, Humberto Spindola, Mercedes Ramos, Isidra Recio, Joao Ernesto Carvalho
Persistent inflammatory conditions can have severe pathological consequences. Although the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is effective, it has side effects, particularly at the gastrointestinal level. There is then a high interest to identify natural anti-inflammatory compounds with no side effects. The anti-inflammatory and anti-nociceptive activities of hen egg lysozyme (LZ), both in its native form and modified by heat treatment, chemically or by enzymatic digestion have been tested in this study...
September 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27668757/mountain-cultivated-ginseng-attenuates-phencyclidine-induced-abnormal-behaviors-in-mice-by-positive-modulation-of-glutathione-in-the-prefrontal-cortex-of-mice
#18
The-Vinh Tran, Eun-Joo Shin, Sung Kwon Ko, Yunsung Nam, Yoon Hee Chung, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Kiyofumi Yamada, Toshitaka Nabeshima, Jae Kyung Byun, Hyoung-Chun Kim
Escalating evidence indicates that ginseng treatment protects against psychotoxic behaviors and memory impairment. Although the underlying mechanism of schizophrenia remains elusive, recent investigations proposed that downregulation of glutathione (GSH) can be involved in the pathogenesis of this disorder. Since little is known about the effects of ginseng in a schizophrenia-like animal model, we selected mountain-cultivated ginseng (MG) from a variety of ginseng extracts to investigate the effect of ginseng on the psychosis induced by phencyclidine (PCP) in mice...
September 26, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27654707/protective-role-of-corilagin-on-a%C3%AE-25-35-induced-neurotoxicity-suppression-of-nf-%C3%AE%C2%BAb-signaling-pathway
#19
Kumju Youn, Seonah Lee, Woo-Sik Jeong, Chi-Tang Ho, Mira Jun
Aggregation and deposition of beta-amyloid peptides (Aβ), a pathological hallmark of Alzheimer's disease, has been recognized as a potent activator of neuroinflammation and neuronal dysfunction. In this study, the underlying molecular mechanisms responsible for the neuroprotective effects of corilagin against Aβ25-35-triggered neurotoxicity and inflammatory responses were investigated in PC12 cells. Pretreatment with corilagin effectively protected PC12 cells against Aβ25-35-induced damage and apoptosis...
September 21, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27627579/aged-garlic-supplement-protects-against-lipid-peroxidation-in-hypercholesterolemic-individuals
#20
Xing Lin Ho, Shin Yih Tsen, Mei Yen Ng, Wei Ni Lee, Aileen Low, Wai Mun Loke
The health benefits of raw garlic intake has been extensively studied, but little is known about the biological effects of aged garlic consumption. A randomized, placebo-controlled, parallel-arm, double-blinded trial involving 41 hypercholesterolemic individuals was conducted to simultaneously examine and compare the blood lipid lowering and antioxidant effects after acute and extended exposures to aged and raw garlic supplements (1080 mg daily). Aged and raw garlic did not affect blood lipid concentrations in these hypercholesterolemic participants after acute and 13-week supplementation...
September 14, 2016: Journal of Medicinal Food
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