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Journal of Medicinal Food

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https://www.readbyqxmd.com/read/28103133/role-of-choline-in-the-modulation-of-degenerative-processes-in-vivo-and-in-vitro-studies
#1
Tania Merinas-Amo, Inmaculada Tasset-Cuevas, Antonio M Díaz-Carretero, Ángeles Alonso-Moraga, Fernando Calahorro
The purpose of the present study was to examine the nutraceutical potential of choline as an added value to its well-known brain nutrient role. Several toxicity, antitoxicity, genotoxicity, antigenotoxicity, and longevity endpoints were checked in the somatic mutation and recombination test in in vivo Drosophila animal model. Cytotoxicity in human leukemia-60 cell line (HL-60) promyelocytic and NIH3T3 mouse fibroblast cells, proapoptotic DNA fragmentation, comet assay, methylation status, and macroautophagy (MA) activity were tested in in vitro assays...
January 19, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098506/capsicum-annuum-var-grossum-bell-pepper-inhibits-%C3%AE-secretase-activity-and-%C3%AE-amyloid1-40-aggregation
#2
Omodesola Oluwafisayo Ogunruku, Ganiyu Oboh, Sabina Passamonti, Federica Trammer, Aline Augusti Boligon
The deposition of amyloid protein as senile plaques is the major signature of Alzheimer's disease (AD). It is produced by the sequential cleavage of the amyloid precursor protein by secretases. Moreover, peppers are noted for their antiaging and cognitive enhancing properties. Thus, in this study, the effects of polyphenol-rich extracts from bell pepper on amyloid production and aggregation in vitro were investigated. Bell pepper (ripe and unripe) was extracted with methanol-1 N HCl (1:1 v/v). Thereafter, the inhibitory potentials of the extracts on β-secretase and β-amyloid1-40 aggregation were determined...
January 18, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28061036/antioxidant-antidiabetic-and-antihypertensive-properties-of-echinacea-purpurea-flower-extract-and-caffeic-acid-derivatives-using-in-vitro-models
#3
Shiow-Ying Chiou, Jih-Min Sung, Po-Wei Huang, Sheng-Dun Lin
The extraction yield, total phenols, caffeic acid derivatives (CAD), and antioxidant properties of 50% ethanolic Echinacea purpurea flower extract were determined. The in vitro inhibitory effects of 50% ethanolic extract and CAD on α-amylase, α-glucosidase, and angiotensin-converting enzyme (ACE) linked with type 2 diabetes were also investigated. The extraction yield, total phenols, and total CAD of the extract were 27.04%, 195.69 mg CAE/g and 78.42 mg/g, respectively. Cichoric acid (56.03 mg/g) was the predominant CAD compound in the extract...
January 6, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28005446/the-effect-of-agave-tequilana-weber-inulin-on-postprandial-ghrelin-concentration-in-obese-patients
#4
Betsabe Contreras-Haro, Jose A Robles-Cervantes, Manuel Gonzalez-Ortiz, Esperanza Martinez-Abundis, Claudia Espinel-Bermudez, Martha P Gallegos-Arreola, Karina C Morgado-Castillo
This study was performed to investigate the effect of Agave tequilana Weber inulin on postprandial ghrelin levels in obese patients. A randomized, double-blind, cross-over design was performed. A total of 14 patients were allocated into two groups: one group received a drink that contained 500 mL lemon water, 24 g of A. tequilana Weber inulin, and 75 g glucose and the other group received a placebo drink with 500 mL lemon drink and 75 g of glucose. After a 7-day washout period, the groups were crossed...
December 22, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27977322/blue-maize-extract-improves-blood-pressure-lipid-profiles-and-adipose-tissue-in-high-sucrose-diet-induced-metabolic-syndrome-in-rats
#5
Rosa Isela Guzmán-Gerónimo, Tania Margarita Alarcón-Zavaleta, Rosa María Oliart-Ros, José Enrique Meza-Alvarado, Socorro Herrera-Meza, José Luis Chávez-Servia
The effect of blue maize extract in factors related to metabolic syndrome (MS) in Wistar rats was investigated. Total polyphenols, monomeric anthocyanins, and antioxidant activity were analyzed in blue maize. MS was induced in Wistar rats fed with high-sucrose (HS) diet for 12 weeks. During a period of 4 weeks, blue maize extract was administrated to HS groups fed with high-sucrose and high-cholesterol-high-sucrose (HS+C) diets. In the blue maize extract administered by orogastric cannulation, the levels of total polyphenols and anthocyanins were 9...
December 15, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27976976/antiadipogenic-effects-and-mechanisms-of-combinations-of-genistein-epigallocatechin-3-gallate-and-or-resveratrol-in-preadipocytes
#6
Bulbul Ahmed, Siqin Liu, Hongwei Si
Natural bioactive compounds are considered an excellent alternative strategy for developing effective, safe, and cost-effective antiobesity agents. The aim of this study was to investigate if combinations of soy bean genistein (G), green tea epigallocatechin-3-gallate (E), and/or grape resveratrol (R) at low dosages synergistically inhibit preadipocyte differentiation both in 3T3-L1 cells and human primary preadipocytes (HPAs). Our results show that combinations of G, E, and/or R additively inhibited preadipocyte differentiation (39-56% of control) both in 3T3-L1 cells at 30 μM and HPAs at 15 μM, while the individual compounds have no antiadipogenic effect at the selected concentrations...
December 15, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27976972/the-protective-effects-of-probiotic-bacteria-on-cadmium-toxicity-in-rats
#7
Sinisa Djurasevic, Adel Jama, Nebojsa Jasnic, Predrag Vujovic, Milos Jovanovic, Dragana Mitic-Culafic, Jelena Knezevic-Vukcevic, Maja Cakic-Milosevic, Konstantin Ilijevic, Jelena Djordjevic
One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated...
December 15, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098518/a-4-nitroquinoleneoxide-induced-pleurotus-eryngii-mutant-variety-increases-pin1-expression-in-rat-brain
#8
Yoonhwa Jeong, Mina Jung, Myeung Ju Kim, Cheol Ho Hwang
To develop Pleurotus eryngii varieties with improved medicinal qualities, protoplasts of P. eryngii were mutagenized using 4-nitroquinoleneoxide. The effects of the resulting variant mushrooms on a human cell were evaluated by applying their aqueous extracts to the human hepatoma cell line, HepG2, in vitro and examining any alteration in the proteomes of the treated HepG2. The P. eryngii mutant, NQ2A-12, was selected for its effects on increasing the expression level of Pin1 in HepG2. Pin1 is one of the peptidyl-prolyl cis-trans isomerases known to play an important role in repressing Alzheimer's disease pathogenesis...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098517/antiobesity-effects-of-sansa-crataegi-fructus-on-3t3-l1-cells-and-on-high-fat-high-cholesterol-diet-induced-obese-rats
#9
Jae-Joon Lee, Hyun-Joo Lee, Seon-Woo Oh
This study was performed to investigate the effects of Crataegi fructus ethanol extracts (CFEEs) on the differentiation of 3T3-L1 cells, and to evaluate the effects of C. fructus powder (CFP) on lipid metabolism and its antiobesity effect in rats fed a high-fat and high-cholesterol (HFC) diet. Both in vitro and in vivo studies were performed for physiological activity and antiobesity effects on the serum, liver, and adipose tissues in obesity-induced rats. CFEEs showed significant inhibitory action on differentiation and triglyceride (TG) accumulation in 3T3-L1 mature cells in a dose-dependent manner...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098516/germacrone-attenuates-hyperlipidemia-and-improves-lipid-metabolism-in-high-fat-diet-induced-obese-c57bl-6j-mice
#10
Yuan-Ri Guo, Se-Young Choung
We previously showed that Aster spathulifolius Maxim extract (ASE) reduced body weight gain and serum and liver lipid levels and significantly suppressed serum insulin and leptin concentrations in high-fat diet (HFD)-induced obese rats. Germacrone (GM) was identified as a potent bioactive constituent of ASE. In this study, we hypothesized that GM can attenuate hyperlipidemia by alleviating fatty acid (FA) synthesis/uptake and improve lipid metabolism by stimulating FA β-oxidation in HFD-induced obese C57BL/6J mice...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098515/a-randomized-open-label-trial-to-assess-the-effect-of-plant-sterols-associated-with-ezetimibe-in-low-density-lipoprotein-levels-in-patients-with-coronary-artery-disease-on-statin-therapy
#11
Gisane Biacchi Gomes, Ana Denise Zazula, Leonardo Seidi Shigueoka, Rosangela Alquieri Fedato, Ana Beatriz Brenner Affonso da Costa, Luiz Cesar Guarita-Souza, Cristina Pellegrino Baena, Marcia Olandoski, José Rocha Faria-Neto
Consumption of food products enriched with plant sterols and the use of ezetimibe reduce cholesterol absorption in the intestine and effectively reduce low-density lipoprotein (LDL) plasma levels. We evaluated the therapeutic effect of the ezetimibe+plant sterol association in patients with coronary artery disease still not reaching recommended lipid levels despite the use of statins. We performed a prospective open-label study with 41 patients with stable coronary disease and LDL >70 mg/dL. Patients were randomized into four groups for a 6-week treatment: the control (CT) group remained on the same statin therapy, the ezetimibe (EZ) group received 10 mg/day of ezetimibe, the plant sterol (PS) group received spread enriched with 2 g of plant sterols, and the ezetimibe+PS (EZ+PS) group received 10 mg/day EZ +2 g PS...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28098514/edible-and-medicinal-mushrooms-emerging-brain-food-for-the-mitigation-of-neurodegenerative-diseases
#12
Chia-Wei Phan, Pamela David, Vikineswary Sabaratnam
There is an exponential increase in dementia in old age at a global level because of increasing life expectancy. The prevalence of neurodegenerative diseases such as dementia and Alzheimer's disease (AD) will continue to rise steadily, and is expected to reach 42 million cases worldwide in 2020. Despite the advancement of medication, the management of these diseases remains largely ineffective. Therefore, it is vital to explore novel nature-based nutraceuticals to mitigate AD and other age-related neurodegenerative disorders...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28060552/the-root-extract-of-gentiana-macrophylla-pall-alleviates-b19-ns1-exacerbated-liver-injuries-in-nzb-w-f1-mice
#13
Ming-Jen Sheu, Chun-Ching Chiu, Deng-Jye Yang, Tsai-Ching Hsu, Bor-Show Tzang
The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao," have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28026992/sesquiterpene-lactone-composition-and-cellular-nrf2-induction-of-taraxacum-officinale-leaves-and-roots-and-taraxinic-acid-%C3%AE-d-glucopyranosyl-ester
#14
Tuba Esatbeyoglu, Betina Obermair, Tabea Dorn, Karsten Siems, Gerald Rimbach, Marc Birringer
Taraxacum officinale, the common dandelion, is a plant of the Asteraceae family, which is used as a food and medical herb. Various secondary plant metabolites such as sesquiterpene lactones, triterpenoids, flavonoids, phenolic acids, coumarins, and steroids have been described to be present in T. officinale. Dandelion may exhibit various health benefits, including antioxidant, anti-inflammatory, and anticarcinogenic properties. We analyzed the leaves and roots of the common dandelion (T. officinale) using high-performance liquid chromatography/mass spectrometry to determine its sesquiterpene lactone composition...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28009536/leucine-protects-against-skeletal-muscle-atrophy-in-lipopolysaccharide-challenged-rats
#15
Jin Wan, Daiwen Chen, Bing Yu, Yuheng Luo, Xiangbing Mao, Ping Zheng, Jie Yu, Junqiu Luo, Jun He
Skeletal muscle atrophy is a decrease in muscle mass that occurs when protein degradation exceeds protein synthesis. Leucine (Leu), an essential branched-chain amino acid in animal nutrition, regulates skeletal muscle protein metabolism. Two experiments were conducted to evaluate whether Leu could alleviate lipopolysaccharide (LPS)-induced skeletal muscle wasting by modulating skeletal muscle protein synthesis and degradation. A total of 24 rats were randomly allocated into three groups (n = 8): (1) non-challenged control; (2) LPS-challenged control; and (3) LPS +3...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28009525/effects-of-alpha-lipoic-acid-supplementation-on-plasma-adiponectin-levels-and-some-metabolic-risk-factors-in-patients-with-schizophrenia
#16
Bojana Vidović, Srđan Milovanović, Aleksandra Stefanović, Jelena Kotur-Stevuljević, Marija Takić, Jasmina Debeljak-Martačić, Maja Pantović, Brižita Đorđević
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alpha-lipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28005447/gynostemma-pentaphyllum-ethanolic-extract-protects-against-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#17
Kyung Sook Kim, Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Yoon Jeong Cho, Kyung Eun Lee, Seung Hwan Kim, Myung Koo Lee
This study investigated the effects of ethanol extract from Gynostemma pentaphyllum (GP-EX) on memory deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) (MPTP-lesioned mice). MPTP (30 mg/kg/day, 5 days)-lesioned mice showed deficits of habit learning memory and spatial memory, which were further aggravated by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA) (25 mg/kg, 21 days). However, treatment with GP-EX (50 mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice treated with L-DOPA (25 mg/kg): GP-EX prevented the decreases in retention latency time in the passive avoidance test and tyrosine hydroxylase-immunopositive cells and dopamine levels in the nigrostriatum...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27935764/morphofunctional-renal-alterations-in-progeny-of-mice-fed-rhodiola-kirilowii-extracts-or-epigallocatechin-during-pregnancy-and-lactation
#18
Sławomir Lewicki, Ewa Skopińska-Różewska, Barbara Joanna Bałan, Bolesław Kalicki, Janusz Patera, Jacek Wilczak, Aleksander Wasiutyński, Robert Zdanowski
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27893308/evaluation-of-hypotensive-and-antihypertensive-effects-of-velvet-bean-mucuna-pruriens-l-hydrolysates
#19
Luis Chel-Guerrero, Saulo Galicia-Martínez, Juan José Acevedo-Fernández, Jesus Santaolalla-Tapia, David Betancur-Ancona
Hypertension could cause significant worldwide health problems that affect 15-20% of all adults; according to National Health and Nutrition Examination Survey, about 29% of the adult population in the United States are hypertensive. Recent research has shown that peptides derived from the hydrolysis of food proteins can decrease blood pressure. This study was carried out to evaluate the hypotensive and antihypertensive potential of Mucuna pruriens protein hydrolysates in in vitro and in vivo models. M. pruriens protein concentrate was prepared by wet fractionation and enzymatically hydrolyzed using Alcalase(®), Flavourzyme(®), and the sequential system Alcalase-Flavourzyme at different times (5-120 min)...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27982757/relationship-between-plant-food-fruits-vegetables-and-kimchi-consumption-and-the-prevalence-of-rhinitis-among-korean-adults-based-on-the-2011-and-2012-korea-national-health-and-nutrition-examination-survey-data
#20
Yong-Suk Kwon, Yoo-Kyung Park, Hye-Ja Chang, Se-Young Ju
The aim of the current study was to analyze the relationship between plant food (fruits, vegetables, and kimchi) and the prevalence of rhinitis among Korean adults using data from the 2011 and 2012 Korea National Health and Nutrition Examination Survey. A total of 7494 subjects aged from 19 to 64 years participated in a rhinitis morbidity survey, health behavior interview, and 24-h dietary recall test. Individuals with energy intakes less than 500 kcal or more than 5000 kcal were excluded. The results showed that kimchi intake was inversely associated with the prevalence of rhinitis...
December 2016: Journal of Medicinal Food
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