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Journal of Medicinal Food

Cleber da Silveira Torres, Francisnaira da Silva Santos, Elen Landgraf Guiguer, Adriano Cressoni de Araújo, Sandra Maria Barbalho, Patrícia Cincotto Dos Santos Bueno, Maricelma Silva Soares de Souza, Danilo Antonini Alves, Marcelo Lancellott, Haydee Maria Moreira
Morinda citrifolia (MC) and Annona muricata (AM) are popularly used for the treatment of several diseases, including cancer. Our objective was to evaluate the effects of the juice of the MC fruit, and the ethanolic extract of AM leaves on Erhlich tumor cells, in mice and in vitro fibroblastic cells. The animals were divided into G1 and G2: controls; G3: treated with AM, and G4 juice: treated with MC. The animals were subjected to intraperitoneal inoculation of 103 tumor cells and then treated with the plants...
November 9, 2018: Journal of Medicinal Food
Min-Ju Kim, Jung-Mi Yun
Unregulated inflammatory responses lead to massive production of macrophages-activating inflammatory cytokines and chemokines, which may induce diabetes, cancer, and atherosclerosis. Macrophages differentiated from human monocyte (THP-1) have been extensively used in in vitro inflammation models in recent studies. Zerumbone is a major component of the essential oil of Zingiber zerumbet Smith, a type of wild ginger. In this study, we investigated the effects of zerumbone on the secretion of pro-inflammatory cytokines and its underlying mechanistic regulation in lipopolysaccharide (LPS)-activated inflammation of THP-1 cell-derived macrophages...
November 1, 2018: Journal of Medicinal Food
Alena Vanduchova, Pavel Anzenbacher, Eva Anzenbacherova
Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits...
October 27, 2018: Journal of Medicinal Food
Cíntia Tarabal Oliveira, Débora Romualdo Lacerda, Marina Campos Zicker, Laís Bhering Martins, Mauro Martins Teixeira, Raquel Linhares Bello de Araujo, Adaliene Versiani Matos Ferreira
This study aimed to evaluate the effects and the mechanisms of ginger extract intake in the adiposity gain, metabolic and inflammatory disturbances induced by a high-refined carbohydrate (HC) diet in mice. Ginger extract at doses of 200, 600, and 1800 mg/kg was supplemented in the daily food of obese Balb/c mice during an 8-week experiment. Our findings indicate that consumption of high doses of ginger extracts prevents the increase of adiposity induced by HC diet, improves lipid profile, and promotes decrease of inflammatory markers in mice...
October 26, 2018: Journal of Medicinal Food
Washington Rogério de Sousa, Bruno Henrique Lopes Botelho Lourenço, Michelle de Paula Reis, Guilherme Donadel, Marcia Alessandra Arantes Marques, Euclides Lara Cardozo Junior, Ezilda Jacomassi, Salviano Tramontin Belettini, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior, Emerson Luiz Botelho Lourenço
Yerba mate (Ilex paraguariensis A. St.-Hil.; Aquifoliaceae) is a popular tonic and stimulant beverage that is widely consumed in different South American countries. Estimates indicate the consumption of >1 L per day in southern Brazil and Uruguay. Despite its relatively high consumption, data on reproductive toxicity during critical periods of gestation remain unclear. Thus, we evaluated the effects of an aqueous extract of I. paraguariensis leaves ("chimarrão" [IPC]) at two critical periods of gestation in Wistar rats: preimplantation embryonic stage and fetal organogenesis...
October 18, 2018: Journal of Medicinal Food
Sunmin Park, James W Daily, Jeongmin Lee
No abstract text is available yet for this article.
October 11, 2018: Journal of Medicinal Food
Spyridon Karkabounas, Nikolaos Papadopoulos, Chryssa Anastasiadou, Chrysoula Gubili, Dimitrios Peschos, Telemachos Daskalou, Nikolaos Fikioris, Yannis V Simos, Evangelos Kontargiris, Xenophon Gianakopoulos, Vasilios Ragos, Maria Chatzidimitriou
Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients. We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementation with α-lipoic acid (ALA), carnosine, and thiamine. For that purpose, 82 obese type 2 diabetic patients were randomly assigned to 2 groups, and were either supplemented daily with 7 mg ALA/kg body weight, 6 mg carnosine/kg body weight, and 1 mg thiamine/kg body weight or placebo for 8 weeks...
October 11, 2018: Journal of Medicinal Food
Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Rhanany Alan Calloi Palozi, Paulo César de Paula Vasconcelos, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Valter Paes de Almeida, Jane Manfron Budel, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Talisia esculenta (A. St.-Hil.) Radlk. is a large tree belonging to family Sapindaceae and popularly known as "pitombeira" or "pitomba." Although species have relevant economic and medicinal uses in Brazil, no study has investigated its effectiveness as a diuretic, hypotensive, and antihypertensive agent. The aim of this study was to present a detailed anatomical and histochemical study for T. esculenta and provide important safety and efficacy parameters. After morpho-anatomical and microchemical study, a purified aqueous extract (ethanol soluble fraction obtained from T...
October 10, 2018: Journal of Medicinal Food
Ali Acar, Emine Yalçin, Kültiğin Çavuşoğlu
In this study, the protective role of β-carotene against ammonium sulfate-induced toxicity has been evaluated in Mus musculus var. albino mice, along with biochemical and histopathological parameters. Some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine and oxidative stress parameters, malondialdehyde (MDA), and glutathione (GSH) levels in kidney and liver tissues were investigated. The mice were randomly divided into six groups...
October 6, 2018: Journal of Medicinal Food
Abdulhalim Senyigit, Sinem Durmus, Eda Buyukcolpan Mirzatas, Nural Pastacı Ozsobacı, Remise Gelisgen, Matem Tuncdemir, Dervis Ozcelik, Gonul Simsek, Hafize Uzun
Quercetin (QR) is part of a subclass of flavonoids called flavonols. We aimed to investigate the effect of QR on malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and glutathione peroxidase (GSH-Px) activity in the liver of diabetic rats. We compared four groups of male adult Wistar albino rats: a control group, an untreated diabetic group, diabetic groups treated with QR, and QR group. Diabetes was induced by a single injection of streptozotocin (STZ) (50 mg/kg). Animals were kept in standard condition...
October 4, 2018: Journal of Medicinal Food
Arunwan Udomkasemsab, Chattraya Ngamlerst, Karunee Kwanbunjun, Thanyaluk Krasae, Krieangsak Amnuaysookkasem, Pornprapha Chunthanom, Pattaneeya Prangthip
Excessive consumption of a high-fat diet (HFD) is associated with hypercholesterolemia and cardiovascular disease (CVD). Dark purple maoberry (Antidesma bunius) fruit is a very good source of antioxidants. We investigated the effects of maoberry on immune function, lipid profiles, and oxidative stress in HFD-induced hypercholesterolemia. Seventy-two male Sprague Dawley rats were divided into the normal group fed with standard diet (ND); HFD groups (HF); and low, medium, and high dose of maoberry extract groups and a simvastatin group (HF-L, HF-M, HF-H, and HF-S, respectively)...
October 2, 2018: Journal of Medicinal Food
Jaeho Do, Jungwon Gwak, Jung Jin Rho, Kwangseung Lee, Muhammad Irfan, Man Hee Rhee, Dong Chung Kim
The inhibitory effects of taegeuk ginseng extract (TGE) on platelet aggregation and thrombus formation were investigated. The TGE significantly inhibited collagen- and adenosine 5'-diphosphate (ADP)-induced platelet aggregation in vitro in a dose-dependent manner. Also oral administration of TGE to rats significantly prevented ADP- and collagen-induced platelet aggregation ex vivo, but it did not affect the plasma coagulation system. The oral administration of TGE significantly delayed the occlusion of the carotid artery in ferrous chloride-treated rats in vivo...
September 29, 2018: Journal of Medicinal Food
Juliana M A Almeida, Adaliene V M Ferreira, Verena B Oliveira, Marina C Oliveira, Mauro M Teixeira, Maria G L Brandão
Obesity is characterized by a chronic low-grade inflammation, which has been shown to be involved in the development of comorbidities such as insulin resistance, glucose intolerance, and liver damage. Phytochemicals found in plants may modulate inflammation and improve health problems associated with the excess of adiposity. Teas prepared with many plants are used in Brazil for losing weight. In this study, we evaluated the potential of Rudgea viburnoides (Cham.) Benth. on metabolic and inflammatory disarrangement induced by high refined carbohydrate (HC)-containing diet in mice...
September 21, 2018: Journal of Medicinal Food
Renny Reji Mammen, Johannah Natinga Mulakal, Ratheesh Mohanan, Balu Maliakel, Krishnakumar Illathu Madhavamenon
Acetaldehyde, the major cytotoxin formed by the metabolism of alcohol, is responsible for liver injury, extracellular matrix alterations, inflammation, and hangover in heavy drinkers. This study aimed to demonstrate the efficacy of a standardized polyphenolic extract of clove buds (Clovinol) in ameliorating the oxidative stress and inflammation caused by the accumulation of acetaldehyde after binge drinking. We used a randomized, double-blinded crossover study with 16 male social drinkers. The subjects were randomized into two groups of eight subjects and received either placebo or Clovinol in a single hard shell gelatin capsule (250 mg × 1) per day...
September 20, 2018: Journal of Medicinal Food
Mateja Senica, Gregor Mlinsek, Robert Veberic, Maja Mikulic-Petkovsek
Medicinal plants are widely used for the relief of disease symptoms or as dietary supplements. In recent decades, purple coneflower has become extremely well known. An infusion or tincture of purple coneflower can be prepared by anyone simply, inexpensively, and ecologically safely. Three plant parts of purple coneflower were used in the study: extracts from roots, flowers, and leaves were obtained using three different solvents (100% and 40% ethanol and water). High-performance liquid chromatography-mass spectrophotometer identified and quantified 23 individual phenolics...
September 14, 2018: Journal of Medicinal Food
So Ra Kim, Jihyun Je, Kyuho Jeong, Soo Ji Kim, Kyo-Yeon Lee, Sung-Gil Choi, Hwajin Kim, Sang Won Park
Perilla oil has been shown to be beneficial for ameliorating metabolic disorders, but its protective effect is still controversial. We investigated the effect of perilla oil on obesity-induced hepatic and vascular changes in high-fat diet (HFD)-fed mice and provided underlying mechanisms for potential therapeutic applications. Tomato and paprika extract was added to prevent the oxidation during storage of perilla oil. HFD-fed mice were orally administered palm or perilla oil for 90 days. Food intake, body and liver weight, and serum cholesterol levels were measured...
September 12, 2018: Journal of Medicinal Food
Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Yo Miyakoshi, Kenji Fujii
Bowel habits affect the quality of life (QOL) of patients with functional gastrointestinal disorders. This study evaluated the effects of reduced form coenzyme Q 10 (ubiquinol) intake on defecation frequency and stool form in patients with daily abdominal symptoms. This was a single-center, prospective, double-blind, randomized control study. Forty-one patients who had the daily symptom of constipation or diarrhea were randomly assigned at a 1:1 ratio to receive either ubiquinol (150 mg/day) or placebo for 12 weeks...
September 7, 2018: Journal of Medicinal Food
Zengenni Liang, Zhihang Yuan, Gaoyang Li, Fuhua Fu, Yang Shan
The mechanisms underlying the effect of Ganoderma lucidum (Reishi mushroom) polysaccharides (GLP) on obesity are not clear. In this study, GLP were found to attenuate the oleic acid-induced cell viability loss and apoptosis dose dependently in splenic lymphocytes in vitro. The effects of GLP on lipid metabolism, oxidative stress, and apoptosis in mice fed a high-fat diet (HD) were determined. GLP administration (200 and 400 mg/kg bw) significantly lowered the body-weight increases; liver, heart, and white adipose tissues indexes; serum lipid accumulation; and serum and small intestine oxidative stress in mice fed a HD...
September 5, 2018: Journal of Medicinal Food
Amy S Y Lau, Eri Mitsuyama, Toshitaka Odamaki, Jin-Zhong Xiao, Min-Tze Liong
Changes in weather often trigger a myriad of negative impacts on the environment, which eventually affect human health. During the early months of 2016, Malaysia experienced El Niño, with an extremely dry season of almost zero rainfall. At the same time, an increase of more than twofold in fecal secretary immunoglobulin-A (SIgA) levels of healthy preschool children aged 2-6 years was observed, accompanied by an increase in phylum Bacteroidetes, predominantly attributed to genus Bacteroides and Odoribacter, which also positively correlated with fecal SIgA levels...
September 5, 2018: Journal of Medicinal Food
Eui-Seong Park, Eun-Jeong Park, Jia-Le Song, In-Suk Kim, Kun-Young Park
We investigated the preventive effects of Ramyeon made from brown rice-sorghum noodles and doenjang-bamboo salt soup (BS+DB) on colitis induced by dextran sulfate sodium (DSS) in C57BL/6 mice. Noodles were prepared with 10% brown rice and 10% sorghum powders added to wheat flour and potato powder, and soup was made using starter fermented (SF) doenjang powder (32%) and bamboo salt (13.5%). The experimental animals were divided into five groups: Normal, Control, BS (brown rice and sorghum noodles)+DB (doenjang and bamboo salt soup) (BS+DB Ramyeon), W (white flour noodles, commercial one)+DB, W+dC (W+doenjang commercial soup), and W + D (W+SF doenjang powder [100%])...
September 5, 2018: Journal of Medicinal Food
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