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Journal of Medicinal Food

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https://www.readbyqxmd.com/read/28933980/panduratin-a-prevents-tumor-necrosis-factor-alpha-induced-muscle-atrophy-in-l6-rat-skeletal-muscle-cells
#1
Bo-Kyung Sa, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Panduratin A, a prenylated chalcone compound, has anti-obesity, anti-bacterial, anti-cancer, anti-inflammatory, and anti-oxidative activities. However, its preventive effect on muscle atrophy has not been studied. The purpose of this study was to evaluate the inhibitory effect of panduratin A on muscle atrophy and to investigate its molecular mechanisms in tumor necrosis factor-alpha (TNF-α)-treated L6 rat skeletal muscle cells. Panduratin A restored the myotube diameter reduced by TNF-α. At the molecular level, panduratin A elevated phosphatidylinositol 3 kinase/Akt/mammalian target of rapamycin pathway and stimulated the MyoD and myogenin mRNA expression decreased by TNF-α...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28933978/the-glycosidase-treatment-of-gentianae-scabrae-radix-converts-trifloroside-into-deglucosyltrifloroside-with-an-enhancement-of-antioxidative-effects
#2
Eun-Ju Yang, Ju-Gyeong Lee, Kyung-Sik Song
Herbal medicines were subjected to enzyme reaction by using a commercial glycosidase AMG-300L, and were evaluated for enhancement of their antioxidative activities. The methanolic extract of Gentianae Scabrae Radix (GSR) showed the most dramatic changes after enzyme reaction, as seen in the high-performance liquid chromatography profiles and an increase in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect. Trifloroside (1, TF) was identified as being significantly decreased by enzyme reaction, whereas deglucosyltrifloroside (2, DTF) increased...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28926298/association-between-coffee-consumption-and-circulating-levels-of-adiponectin-and-leptin
#3
Chang Beom Lee, Sung Hoon Yu, Na Yeon Kim, Seon Mee Kim, Sung Rae Kim, Seung Joon Oh, Sun Ha Jee, Jung Eun Lee
Coffee has been proposed to have benefits for chronic diseases; however, the relevant mechanism remains to be elucidated. We conducted a cross-sectional study and evaluated the levels of adiponectin and leptin in relation to coffee consumption. We included a total of 4406 individuals (men = 2587 and women = 1819) for adiponectin analysis and 2922 individuals (men = 1731 and women = 1191) for leptin analysis. Participants answered number of cups of coffee per week and types of coffee they consumed and their serum levels of adiponectin and leptin were measured using an enzyme-linked immunosorbent assay...
September 19, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28922057/the-dietary-food-components-capric-acid-and-caprylic-acid-inhibit-virulence-factors-in-candida-albicans-through-multitargeting
#4
Ashwini Jadhav, Supriya Mortale, Shivkrupa Halbandge, Priyanka Jangid, Rajendra Patil, Wasudev Gade, Kiran Kharat, Sankunny Mohan Karuppayil
Capric acid and caprylic acid are the dietary food components. They are found to inhibit the virulence factors like morphogenesis, adhesion, and biofilm formation in the human pathogenic yeast Candida albicans. Our study demonstrated that yeast-to-hyphal signal transduction pathways were affected by capric acid and caprylic acid. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of Cdc35, Hwp1, Hst7, and Cph1 by the treatment with both the fatty acids. Cell elongation gene, Ece1, was surprisingly downregulated by 5208-fold by the treatment of caprylic acid...
September 18, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28910180/nrf2-mediated-ho-1-induction-and-antineuroinflammatory-activities-of-halleridone
#5
Ji Yeon Seo, Euisun Pyo, Junsoo Park, Jong-Sang Kim, Sang Hyun Sung, Won Keun Oh
Nuclear factor E2-related factor 2 (Nrf2) is the master regulator of antioxidant enzymes and is known to act on the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling pathway. Few studies have examined the bioactivity of halleridone. Herein, we investigated whether halleridone, which was isolated from the stems of the plant Cornus walteri, could regulate Nrf2-mediated heme oxygenase (HO)-1 expression and prevent intramicroglial inflammation induced by amyloid beta (Aβ)1-42 overexpression...
September 14, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28880748/influence-of-b-complex-vitamins-on-the-pharmacokinetics-of-ginsenosides-rg1-rb1-and-ro-after-oral-administration
#6
Peihe Zheng, Yinbin Chen, Yangyang Fu, Hecheng Wang, Jia Wang, Siwen Zheng, Shengyuan Xiao, Yingping Wang
After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg1, protopanaxadiol-type saponin Rb1, and oleanolic acid-type saponin Ro after oral administration...
September 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28880711/curcumin-alleviates-the-functional-gastrointestinal-disorders-of-mice-in-vivo
#7
Jing Yu, Wen-Hua Xu, Wei Sun, Yi Sun, Zhi-Li Guo, Xiao-Ling Yu
Curcumin is a natural polyphenol extracted from the turmeric rhizome, which has a wide range of biological activities, but until now the effects of curcumin on the gastrointestinal peristalsis have not been fully understood. In vivo study, we observed the effects of curcumin on gastric emptying and intestinal propulsion rates of mice in normal state and in delayed state by atropine (ATR) or nitric oxide precursor L-arginine (L-Arg). An in vitro study explored the direct effects of curcumin on the intestinal contractility, but were studied through measuring spontaneous contraction of isolated jejunum of mice...
September 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28872427/long-term-dietary-supplementation-with-yerba-mate-ameliorates-diet-induced-obesity-and-metabolic-disorders-in-mice-by-regulating-energy-expenditure-and-lipid-metabolism
#8
Myung-Sook Choi, Hyo Jin Park, Sang Ryong Kim, Do Yeon Kim, Un Ju Jung
This study evaluated whether long-term supplementation with dietary yerba mate has beneficial effects on adiposity and its related metabolic dysfunctions in diet-induced obese mice. C57BL/6J mice were randomly divided into two groups and fed their respective experimental diets for 16 weeks as follows: (1) control group fed with high-fat diet (HFD) and (2) mate group fed with HFD plus yerba mate. Dietary yerba mate increased energy expenditure and thermogenic gene mRNA expression in white adipose tissue (WAT) and decreased fatty acid synthase (FAS) mRNA expression in WAT, which may be linked to observed decreases in body weight, WAT weight, epididymal adipocyte size, and plasma leptin level...
September 5, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28854336/in-vitro-anti-inflammatory-activity-of-ilex-cornuta-extract-mediated-by-inhibition-of-extracellular-signal-regulated-kinase-phosphorylation
#9
Jisu Kim, Wonku Kang, Hyeyoung Min
Ilex cornuta, commonly known as Chinese holly, is an evergreen shrub from the family Aquifoliaceae, and it is widely distributed in Korea and China. In folk medicine, the leaves of I. cornuta are used for treatment of several disorders, including weakness of the waist and knees, arthrodynia, headache, acute conjunctivitis, toothache, urticaria, rheumatic arthralgia, and cardiovascular diseases. In this study, we investigated the anti-inflammatory effects of an I. cornuta leaf ethanol extract (ILE) and its underlying mechanisms of action...
August 30, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28850308/a-novel-highly-bioavailable-curcumin-formulation-improves-symptoms-and-diagnostic-indicators-in-rheumatoid-arthritis-patients-a-randomized-double-blind-placebo-controlled-two-dose-three-arm-and-parallel-group-study
#10
Augustine Amalraj, Karthik Varma, Joby Jacob, Chandradhara Divya, Ajaikumar B Kunnumakkara, Sidney J Stohs, Sreeraj Gopi
Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment of RA has many potential side effects. Natural phytonutrients may serve as alternative strategies for the safe and effective treatment of RA, and curcuminoids have been used in Ayurvedic medicine for the treatment of inflammatory conditions for centuries. In this study, a novel, highly bioavailable form of curcumin in a completely natural turmeric matrix was evaluated for its ability to improve the clinical symptoms of RA...
August 29, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28850305/in-vitro-bioaccessibility-and-effect-of-mangifera-indica-ataulfo-leaf-extract-on-induced-dyslipidemia
#11
Eli Mireya Sandoval-Gallegos, Esther Ramírez-Moreno, Juan Gayosso De Lucio, José Arias-Rico, Nelly Cruz-Cansino, Mario I Ortiz, Raquel Cariño-Cortés
Cardiovascular diseases (CVDs) are the leading causes of death in the world, and epidemiological evidence points to dietary habits, stress, and obesity as major risk factors promoting pathological conditions like atherosclerosis, hypertension, and thrombosis. Current therapeutic approaches for CVDs rely on lifestyle changes and/or the use of drug agents. However, since the efficacy of such interventions is often limited by poor compliance and/or significant side effects, continued research on new preventive and therapeutic approaches is much needed...
August 29, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28836883/review-on-sustained-relief-of-osteoarthritis-symptoms-with-a-proprietary-extract-from-pine-bark-pycnogenol
#12
Peter Jörg Rohdewald
The review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild osteoarthritis (OA), stage 1 and 2. The extract exerts antioxidative, anti-inflammatory, and chondroprotective effects in vitro and in vivo. Its phenolic acids as well as catechin and taxifolin are quickly absorbed. Active metabolites, produced by gut microbiota in the intestinal tract from oligomeric procyanidins, appear in blood 6 h following ingestion and remain for at least 14 h, providing a long-lasting flow of anti-inflammatory substances for relief of OA symptoms...
August 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28816630/glycoproteins-and-polysaccharides-are-the-main-class-of-active-constituents-required-for-lymphocyte-stimulation-and-antigen-specific-immune-response-induction-by-traditional-medicinal-herbal-plants
#13
Young-Ok Son, Sung-Ho Kook, Jeong-Chae Lee
Traditional herbal remedies stimulate and modulate the immune system, and it is thought that their glycoproteins and polysaccharides are responsible for this activity. We prepared crude water, protein, and polysaccharide extracts from Atractylodes macrocephala Koidz, Helianthus annuus L., Scutellaria barbata D. Don, and Hedyotis diffusa Willd, respectively, and compared their immune-stimulating activities in vitro and in vivo. All protein and polysaccharide samples of the plants led to greater lymphocyte proliferation and TNF-α and IL-6 production in cultured splenocytes than did the crude water extracts at the same concentrations tested...
August 17, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28816580/cardioprotective-effects-of-a-phlorotannin-extract-against-doxorubicin-induced-cardiotoxicity-in-a-rat-model
#14
Hyo-Suk Ahn, Dong-Hyeon Lee, Tae-Jung Kim, Hyeon-Cheol Shin, Hui-Kyung Jeon
Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxicity in a rat model. A total of 42 rats were divided into six groups: control, low-dose SPN (LDS), high-dose SPN (HDS), DOX, DOX with low-dose SPN (DOX+LDS), and DOX with high-dose SPN (DOX+HDS)...
August 17, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28792778/stevia-rebaudiana-bertoni-a-natural-alternative-for-treating-diseases-associated-with-metabolic-syndrome
#15
Areli Carrera-Lanestosa, Yolanda Moguel-Ordóñez, Maira Segura-Campos
Stevia rebaudiana (SR) is often used by the food industry due to its steviol glycoside content, which is a suitable calorie-free sweetener. Further, both in vitro and in vivo studies indicate that these glycosides and the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, and anticancer. This work reviews the antiobesity, antihyperglycemic, antihypertensive, and antihyperlipidemic effects of the majority of glycosides and aqueous/alcoholic extracts from the leaves, flowers, and roots of the SR...
August 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28777691/behavioral-effect-of-sterculia-apetala-seed-oil-consumption-in-male-zucker-rats
#16
Socorro Herrera-Meza, Juan Francisco Rodríguez-Landa, Armando J Martínez, Grecia Herrera-Meza, Rafael Fernández-Demeneghi, Karla Reyes-Saldaña, Rosa María Oliart-Ros
Sterculia apetala (order: Malvales, family: Sterculiaceae) seed oil contains two cyclopropene fatty acids: sterculic and malvalic acid. Both positive and negative effects have been associated with the consumption of sterculic oil. In Mexico, S. apetala seeds are consumed after being boiled or roasted, used as chocolate flavoring, and utilized as animal fodder. Therefore, it is important to evaluate whether the consumption of this seed has a negative impact on the organism. The aim of this study was to evaluate the effect of administration of sterculic oil, during an 8-week period, on anxiety-like behavior and spontaneous locomotor activity in Zucker rats, analyzed through light/dark and open-field tests...
August 4, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28767008/the-edible-mushroom-pleurotus-djamor-produces-metabolites-with-lethal-activity-against-the-parasitic-nematode-haemonchus-contortus
#17
Jesús Antonio Pineda-Alegría, José Ernesto Sánchez-Vázquez, Manases González-Cortazar, Alejandro Zamilpa, María Eugenia López-Arellano, Edgar Josúe Cuevas-Padilla, Pedro Mendoza-de-Gives, Liliana Aguilar-Marcelino
Pleurotus djamor is an edible mushroom that has medicinal properties. This study aimed to assess the in vitro activity of P. djamor extracts and fractions against Haemonchus contortus eggs and exsheathed infective larvae (L3). Crude hydroalcoholic extracts were obtained by maceration and fractions were obtained through chromatography. Metabolite identity was determined using gas chromatography/mass spectrometry (GC-MS) analysis. The results showed that P. djamor extracts had no significant activity against eggs at the concentrations used...
August 2, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28749738/nutraceutical-potential-of-new-alfalfa-medicago-sativa-ingredients-for-beverage-preparations
#18
Maria Guadalupe Soto-Zarazúa, Moustapha Bah, Anabela Silvia Gomes Costa, Francisca Rodrigues, Filipa Botelho Pimentel, Isela Rojas-Molina, Alejandra Rojas, Maria Beatriz Prior Pinto Oliveira
Alfalfa (Medicago sativa) has been extensively used as animal feed, due to its fiber, protein, minerals, and vitamins, being also a useful source of phenolic compounds with potential therapeutic benefits. Nevertheless, its potential use as human ingredient is scarce. The aim of this work was to assess the nutritional composition, amino acid profile, and antioxidant capacity (AOC) of freeze-dried juice (FDJ) and fibrous residual material (RM), two new alfalfa-derived products (Adps) recently launched as ingredients for beverage preparations...
July 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28737474/artemisia-dracunculus-extracts-obtained-by-organic-solvents-and-supercritical-co2-produce-cytotoxic-and-antitumor-effects-in-mice-with-l5178y-lymphoma
#19
Martha Hilda Navarro-Salcedo, Jorge Ivan Delgado-Saucedo, Victor Hugo Siordia-Sánchez, Luis J González-Ortiz, Gustavo Adolfo Castillo-Herrera, Ana M Puebla-Pérez
We investigated the cytotoxic and antitumor effects of nine leaf extracts from Artemisia dracunculus (Tarragon). Five extracts were obtained using different organic solvents and four by supercritical CO2. The cytotoxic effects were expressed as IC50 in 100, 80, 80, 100, and 80 μg/mL by respective solvents: hexane, ethyl acetate, acetone, ethanol, and acetonitrile in L5178Y lymphoma cells. For supercritical CO2 extract A, IC50 was 100 μg/mL; for extracts C and D, IC50 was 150 μg/mL. The antitumor activity was assessed through a tumor growth inhibition test that measured ascites fluid volume and tumor cell counts of BALB/c mice (2 × 10(4) cells L5178Y i...
July 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28708468/a-botanical-composition-from-morus-alba-ilex-paraguariensis-and-rosmarinus-officinalis-for-body-weight-management
#20
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
Obesity is the largest and fastest growing public health catastrophe in the world affecting both adults and children with a prevalence impacting more than one-third of United States (US) adult population. Although the long-term solution lies in lifestyle changes in the form of dieting and exercise, intervention is required for those who are already obese. Unfortunately, treatment options remain quite limited due to associated side effects of conventional therapeutics. As a natural alternative, in this study we describe the beneficial effect of a standardized composition (UP603) comprised of extracts from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis in improving metabolic disorders in high fat diet (HFD) and high fat & high fructose diet (HFFD) induced obese C57BL/6J mice...
July 14, 2017: Journal of Medicinal Food
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