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Journal of Medicinal Food

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https://www.readbyqxmd.com/read/28622482/antidiabetic-properties-of-an-apple-kale-extract-in-vitro-in-situ-and-in-mice-fed-a-western-type-diet
#1
Anke Schloesser, Tuba Esatbeyoglu, Gerhard Schultheiß, Henning Vollert, Kai Lüersen, Alexandra Fischer, Gerald Rimbach
Type 2 diabetes mellitus (T2DM) is a common and increasingly prevalent metabolic disorder, and effective preventive strategies against this disease are needed. The aim of the present study was to evaluate the potential antidiabetic properties of a dietary apple/kale extract (AKE), which was rich in phlorizin and flavonoids, in laboratory mice. Mice were fed a control diet, a Western-type high-sugar, high-fat diet (WTD), or a WTD plus AKE for 10 weeks. Body weight, food and energy intake, body composition, and blood glucose level were recorded in addition to the postprandial rise in blood glucose concentration after a single administration of glucose (oral glucose tolerance test, OGTT)...
June 16, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28622474/larch-arabinogalactan-attenuates-myocardial-injury-by-inhibiting-apoptotic-cascades-in-a-rat-model-of-ischemia-reperfusion
#2
Sun-Ha Lim
We reported previously that supplementation with apple pectin, a dietary fiber, reduced myocardial injury in a rat model of ischemia-reperfusion. In this study, we further investigated an arabinogalactan, one of the constituent polysaccharides of pectin, to determine which domains comprising pectin were responsible for the protection. In a rat model of 30-min ischemia followed by 3-h reperfusion, supplementation with larch arabinogalactan (LAG) over 50 mg/kg/day significantly reduced infarct size. Reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry, and immunoblot analyses showed that intake of LAG blocked the steps involved in apoptotic cascades through downregulation of gelsolin gene expression at the protein (Gelsolin) level, inhibition of p38 phosphorylation in mitogen-activated protein kinase (MAPK) pathways, decreased bax/bcl-2 ratio at the protein (Bax/Bcl-2) level, which was correlated with the ratio at the mRNA level, inhibition of the conversion of Procaspase protein to Caspase-3 protein, and consequently a decrease in apoptotic cells...
June 16, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28613963/cytotoxic-and-antimicrobial-activities-of-cantharellus-cibarius-fr-cantarellaceae
#3
Marina Kolundžić, Tatjana Stanojković, Jelena Radović, Ana Tačić, Margarita Dodevska, Marina Milenković, Francesca Sisto, Carla Masia, Giampietro Farronato, Vesna Nikolić, Tatjana Kundaković
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 μg/mL...
June 14, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28598706/citrus-tachibana-leaves-ethanol-extract-alleviates-airway-inflammation-by-the-modulation-of-th1-th2-imbalance-via-inhibiting-nf-%C3%AE%C2%BAb-signaling-and-histamine-secretion-in-a-mouse-model-of-allergic-asthma
#4
Thi Tho Bui, Chun Hua Piao, Soo Mi Kim, Chang Ho Song, Hee Soon Shin, Chang-Hyun Lee, Ok Hee Chai
Asthma is a chronic inflammatory disease of bronchial airway, which is characterized by chronic airway inflammation, airway edema, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration in the lungs. In this study, the therapeutic effect and the underlying mechanism of Citrus tachibana leaves ethanol extract (CTLE) in the ovalbumin (OVA)-induced allergic asthma and compound 48/80-induced anaphylaxis were investigated. Oral administration of CTLE inhibited OVA-induced asthmatic response by reducing airway inflammation, OVA-specific IgE and IgG1 levels, and increasing OVA-specific IgG2a levels...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28598242/antithrombotic-effect-of-fermented-ophiopogon-japonicus-in-thrombosis-induced-rat-models
#5
Yi-Lin Zhang, Mei-Zhu Xi, Young-Bin Choi, Bog-Hieu Lee
In this study, the antithrombotic and thrombolytic ability of second fermented extract of Ophiopogon japonicus (FEOJ) was verified in thrombosis-induced rats. Thrombosis was induced by oral administration of 2% carrageenan for 4 weeks. Five experimental groups (n = 9/group) involved in the study were control group, thrombosis group, low-dose FEOJ group (2 mL/kg, low-dose Ophiopogon japonicus [LOJ]), middle-dose FEOJ group (6 mL/kg, medium-dose Ophiopogon japonicus [MOJ]), and high-dose FEOJ group (12 mL/kg, high-dose Ophiopogon japonicus [HOJ])...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28598237/homocysteine-as-a-diagnostic-and-etiopathogenic-factor-in-children-with-autism-spectrum-disorder
#6
Jan Józefczuk, Wiktoria Kasprzycka, Rafał Czarnecki, Alfreda Graczyk, Paweł Józefczuk, Krzysztof Magda, Urszula Lampart
Substantial characteristics of autism are cognitive and psychophysical disorders. Etiopathogenetic factors are thought to be responsible for development of autism in children with genetic predisposition as well as have their effect on the severity of the disorders. The main problem of early identification of patients affected by autism spectrum disorder is that there are no clear diagnostic criteria. The aim of our study was assessment of hair magnesium and serum homocysteine concentrations in children with autism...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28598231/effect-of-ursolic-acid-on-metabolic-syndrome-insulin-sensitivity-and-inflammation
#7
Alejandra M Ramírez-Rodríguez, Manuel González-Ortiz, Esperanza Martínez-Abundis, Natalhie Acuña Ortega
To evaluate the effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation. A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (30-60 years) with a diagnosis of metabolic syndrome without treatment. They were randomly assigned to two groups of 12 patients, each to receive orally 150 mg of ursolic acid or homologated placebo once a day for 12 weeks. Before and after the intervention, the components of metabolic syndrome, insulin sensitivity (Matsuda index), and inflammation profile (interleukin-6 and C-reactive protein) were evaluated...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28557544/safety-assessment-of-oil-from-pequi-caryocar-brasiliense-camb-evaluation-of-the-potential-genotoxic-and-clastogenic-effects
#8
Giseli Karenina Traesel, Flavio Henrique Souza de Araújo, Luis Henrique Almeida Castro, Fernando Freitas de Lima, Sara Emilia Lima Tolouei Menegati, Priscilla Narciso Justi, Candida Aparecida Leite Kassuya, Claudia Andrea Lima Cardoso, Eliana Janet Sanjinez Argandoña, Silvia Aparecida Oesterreich
Genotoxic data of medicinal plants and functional foods are required as part of the risk assessment by international regulatory agencies. Due to its food consumption and ethnopharmacological relevance, pequi oil (Caryocar brasiliense Camb.) is one of these compounds to be studied. The aim of this study was to evaluate the cytotoxic, genotoxic, and clastogenic effects of the oil from the pulp of C. brasiliense (OPCB) in vivo and in vitro. Initially, the Artemia salina in vitro assay was conducted to determine the cells viability rate of different doses of the OPCB...
May 30, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28537781/blood-pressure-lowering-effects-of-alacalase-hydrolyzed-camellia-seed-hull-in-vitro-and-in-spontaneous-hypertensive-rats
#9
Ho-Jeong Lim, Mi-So Kim, Da-Som Kim, Young Jun Kim, Jin Hyup Lee, Jeong Hoon Pan, Eui-Cheol Shin, Jae Kyeom Kim
High blood pressure is one of the major risk factors for various diseases and angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. In our study, the responsive surface methodology was adopted to establish optimal Alcalase-hydrolysis conditions of camellia seed hull against ACE activity. The optimum conditions are hydrolysis temperature of 50.98°C, enzyme/substrate ratio of 2.85%, and hydrolysis pH of 7.12. In an animal feeding study, spontaneously hypertensive rats were treated with either a low or high dose of hydrolyzed Camellia japonica seed cake over 5 weeks...
May 24, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28514198/piceatannol-reduces-fat-accumulation-in-caenorhabditis-elegans
#10
Peiyi Shen, Yiren Yue, Kee-Hong Kim, Yeonhwa Park
Excess fat accumulation and abnormal metabolism are involved in numerous diseases and thus the research on identification of compounds that can regulate energy homeostasis could significantly facilitate the current effort to prevent and/or treat metabolic disorders. Piceatannol, one of the natural stilbenes, was previously found to decrease lipid accumulation of 3T3-L1 adipocytes. However, its role in fat metabolism in vivo is not known. Thus, Caenorhabditis elegans as an animal model was used in the current study to determine the effect of piceatannol on fat accumulation and its underlying mechanisms...
May 17, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28459647/effect-of-gymnema-sylvestre-administration-on-metabolic-syndrome-insulin-sensitivity-and-insulin-secretion
#11
Laura Y Zuñiga, Manuel González-Ortiz, Esperanza Martínez-Abundis
Gymnema sylvestre is a medicinal plant whose consumption has demonstrated benefits on lipid and glucose levels, blood pressure, and body weight (BWt). The aim of this study was to evaluate the effect of G. sylvestre administration on metabolic syndrome (MetS), insulin secretion, and insulin sensitivity. A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (without pharmacological treatment), 30-60 years old, with diagnosis of MetS in accordance with the modified International Diabetes Federation criteria...
May 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28459610/3-3-diindolylmethane-suppresses-adipogenesis-using-ampk%C3%AE-dependent-mechanism-in-3t3-l1-adipocytes-and-caenorhabditis-elegans
#12
Jihye Lee, Yiren Yue, Yeonhwa Park, Seong-Ho Lee
3,3'-diindolylmethane is a major in vivo metabolite of indole-3-carbinol, a bioactive compound found in cruciferous vegetables. Although 3,3'-diindolylmethane has been implicated to possess antitumorigenic and anti-inflammatory properties, the effect of 3,3'-diindolylmethane on adipogenesis has not been explored previously. Thus, the present study was conducted to determine if 3,3'-diindolylmethane affects adipogenesis using 3T3-L1 adipocytes and Caenorhabditis elegans. Treatment of 3,3'-diindolylmethane significantly reduced fat accumulation without affecting viability in 3T3-L1 adipocytes...
May 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28459609/hypolipidemic-effect-of-moringa-oleifera-lam-leaf-powder-and-its-extract-in-diet-induced-hypercholesterolemic-rats
#13
Shahinaz A Helmy, Nashwa F S Morsy, Shahenda M Elaby, Mohammed A A Ghaly
The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia in rats. Adult male albino rats were divided into six groups. The first group was fed on a basal diet that served as a negative control, whereas the others were fed on a high-fat diet (HFD) containing moringa leaf powder at 0.737% or 1.475% or administered daily with 200 or 400 mg dry moringa leaf extract/kg bw for 60 days...
May 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28445075/dried-plum-ingestion-increases-the-osteoblastogenic-capacity-of-human-serum
#14
Paulina Delgado Cuenca, Lama Almaiman, Simon Schenk, Mark Kern, Shirin Hooshmand
In cell culture studies, dried plum (Prunus domestica L.) polyphenols increased osteoblast alkaline phosphatase (ALP) activity, mineralized nodule formation, and the expression of the bone marker genes runt-related transcription factor 2 (RUNX2) and osterix. The purpose of this study was to determine whether human serum collected 1 and 2 h after dried plum ingestion influenced osteoblast cell activity and gene expression. Five healthy women ingested 100 g of dried plum, and serum samples were collected at baseline (before dried plum ingestion) and 1 and 2 h postingestion of dried plum...
April 26, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28410455/diallyl-polysulfides-from-allium-sativum-as-immunomodulators-hepatoprotectors-and-antimycobacterial-agents
#15
Carel Oosthuizen, Miriam Arbach, Debra Meyer, Chris Hamilton, Namrita Lall
Mycobacterium tuberculosis remains one of the world's deadliest killers, with an annual death rate of ∼1.5 million. The medicinal effects of garlic have been well documented, and natural products have been shown to have antimycobacterial activity. The current study evaluated the efficacy of six Allium sativum L. polysulfide mixtures as antimycobacterial agents together with their cytotoxic, immunomodulatory, and hepatoprotective activities. The microtitre PrestoBlue assay was used to determine the minimum inhibitory concentrations (MIC)...
April 14, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28384008/high-dietary-alpha-tocopherol-or-mixed-tocotrienols-have-no-effect-on-bone-mass-density-or-turnover-in-male-rats-during-skeletal-maturation
#16
Katherine G Tennant, Scott W Leonard, Carmen P Wong, Urszula T Iwaniec, Russell T Turner, Maret G Traber
High levels of alpha-tocopherol, the usual vitamin E supplement, are reported to decrease bone mass in rodents; however, the effects of other vitamin E forms on the skeleton are unknown. To test the hypothesis that high intakes of various vitamin E forms or the vitamin E metabolite, carboxyethyl hydroxy chromanol, were detrimental to bone status, Sprague-Dawley rats (n = 6 per group, 11-week males) for 18 weeks consumed semipurified diets that contained adequate alpha-tocopherol, high alpha-tocopherol (500 mg/kg diet), or 50% Tocomin (250 mg mixed tocopherols and tocotrienols/kg diet)...
April 6, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28622115/ppar%C3%AE-2-c1431t-polymorphism-interacts-with-the-antiobesogenic-effects-of-kochujang-a-korean-fermented-soybean-based-red-pepper-paste-in-overweight-obese-subjects-a-12-week-double-blind-randomized-clinical-trial
#17
Yunkyoung Lee, Youn-Soo Cha, Yongsoon Park, Myoungsook Lee
Kochujang, a Korean fermented soybean-based red pepper paste, has been reported to have beneficial health effects. The aim of this study was to examine the antiobesity effects of Kochujang as a supplement in overweight/obese subjects according polymorphisms in the obesity-linked gene, peroxisome proliferator activator receptor γ (PPARγ2). Sixty overweight/obese subjects, who had body mass indexes (BMI, kg/m(2)) ≥23 or waist/hip ratios (WHR) ≥0.90 for males or ≥0.85 for females, were randomly assigned to either taking 32 g/day of placebo or Kochujang for 12 weeks...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28581882/nutriproteomic-analysis-of-hwangmaemok-induced-antiangiogenic-effect-using-antibody-arrayed-protein-chip-assay
#18
Yu Mi Park, Min-A Kim, Hee Tae Jung, Hwa Jeong Kang, Hwa-Seung Yoo, In-Cheol Kang
We investigated the antiangiogenic effects of Lindera obtusiloba Blume (Hwangmaemok, HMM), which is a plant in the Lauraceae family that is commonly used to treat colds and gastritis. Moreover, given that a recent study reported the inhibitory effects of HMM extract on cancer metastasis, we hypothesized that HMM extract might possess and antiangiogenic function. Thus, this study was conducted to investigate the effects of HMM extract on endothelial cell proliferation, migration, and neovascularization in chick chorioallantoic membrane (CAM), and investigated the molecular mechanism of antiangiogenesis using a ProteoChip-based proteomics technology...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28581877/cellular-antioxidant-and-anti-inflammatory-effects-of-coffee-extracts-with-different-roasting-levels
#19
Soohan Jung, Min Hyung Kim, Jae Hee Park, Yoonhwa Jeong, Kwang Suk Ko
During roasting, major changes occur in the composition and physiological effects of coffee beans. In this study, in vitro antioxidant effects and anti-inflammatory effects of Coffea arabica green coffee extracts were investigated at different roasting levels corresponding to Light, Medium, City, and French roast. Total caffeine did not show huge difference according to roasting level, but total chlorogenic acid contents were higher in light roasted coffee extract than other roasted groups. In addition, light roasted coffee extract had the highest antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28581876/hypolipidemic-activity-of-quercus-acutissima-fruit-ethanol-extract-is-mediated-by-inhibition-of-acetylation
#20
Jin-Taek Hwang, Hyo-Kyoung Choi, Sung Hee Kim, Sangwon Chung, Haeng Jeon Hur, Jae Ho Park, Min-Yu Chung
The acetylation of histone and nonhistone proteins is associated with adipogenesis. The objective of the present study was to investigate whether an ethanol extract of Quercus acutissima fruit (QF) exhibits antiobesity effects through inhibition of acetylation in 3T3-L1 preadipocytes and high fat diet (HFD)-fed obese mice. We observed that QF acts as a histone acetyltransferase (HAT) inhibitor and that QF (400 μg/mL) markedly inhibits the activity of p300 and CREB-binding protein. QF (200 μg/mL) significantly attenuated lipid accumulation without apparent toxicity, which is likely attributable to a decrease in the expressions of lipogenic proteins, including fatty acid synthase, peroxisome proliferator-activated receptor gamma, sterol regulatory element-binding protein 1, and CCAAT-enhancer-binding proteins alpha that were otherwise increased by MDI (a hormonal cocktail containing methyl isobutylmethylxanthine, dexamethasone, and insulin)...
June 2017: Journal of Medicinal Food
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