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Journal of Medicinal Food

Gyoseon Goya M Ryeom, Weon Jeong Bang, Young Bu Kim, Go Eun Lee
Tannins are a type of polyphenols found in several fruits such as grapes and berries, and nuts such as aronias and acorns. Both hydrolyzable tannins and condensed tannins are referred to as tannins. Among the hydrolyzable tannins, gallotannin has a strong antioxidative property and is known to protect the skin by inhibiting the precursors of elastolytic enzymes. However, its mechanism of protection against ultraviolet B (UVB) damage in human fibroblasts and keratinocytes has not yet been elucidated. In this study, we investigate the antioxidant and antiaging effect of gallotannin on UVB-irradiated human cells by studying its effect on extracellular signal-regulated kinases/c-Jun N-terminal kinases (EKRs/JNKs) signaling related to cell growth and differentiation/stress apoptosis...
July 13, 2018: Journal of Medicinal Food
Hyuk-Jin Chung, Jae-Hun Sim, Tae-Sun Min, Hyung-Kyoon Choi
The intestinal microflora plays important roles in the health of the host, such as nutrient processing and the modulation of intestinal immune responses. The constituents of the diet greatly affect the composition of the microbiota and its metabolites. The human intestinal microbiota is made up of around 100 trillion microbial cells encompassing at least 300 species. Consuming probiotics may lead to changes in the intestinal microflora that influence host health. Metabolomics is a powerful tool for revealing metabolic changes in biofluids, tissues, and organs of hosts induced by the consumption of probiotics, and lipidomics in particular is a technical approach that focuses on the analysis of lipids in various cells and biofluids...
July 13, 2018: Journal of Medicinal Food
Haeun Kim, Kae Won Cho, Jeongho Jeong, Kibeum Park, Yungsun Ryu, Knowledge Mudhibadhi Moyo, Hyun Kyung Kim, Gwang-Woong Go
Red pepper seed, a by-product of red pepper, has been reported to have antioxidant and antiobesity activities. However, its role in diabetes has not yet been highly investigated. Glucose homeostasis is mainly maintained by insulin, which suppresses glucose production in the liver and enhances glucose uptake in peripheral tissues. In this study, we investigated the underlying mechanisms through which red pepper seed extract (RPSE) affects glucose production in AML12 hepatocytes and glucose uptake in C2C12 myotubes...
July 3, 2018: Journal of Medicinal Food
Jun-Young Sung, Sok Park, Soon-Gill Lim, Sun-Kyung Lee, Deuk-Mo Kang, Minki Lee, Hee-Jae Kim
In this pilot study, we investigated the effect of spatone, a naturally occurring mineral water supplement, on endurance capacity and inflammatory cytokines in wrestlers undergoing a rapid weight control program. Nine amateur university wrestlers participated and were randomly divided into placebo- and spatone-treated groups. The study used a crossover design, including a 4-week washout period. The rapid weight control program was focused on body weight loss, while maintaining their athletic performance (muscular strength and cardiovascular endurance)...
June 29, 2018: Journal of Medicinal Food
Chandrakala Aluganti Narasimhulu, Aladdin Riad, Sampath Parthasarathy
Diet and exercise are recommended both as a prophylactic and as a therapeutic approach for patients with established coronary artery disease. We previously reported that sesame oil (SESO) and its aqueous extract (SOAE) showed antiatherosclerotic and anti-inflammatory properties. We also observed that genes involved in reverse cholesterol transport (RCT) might be activated. In this study, we tested whether post-treatment with SESO or SOAE would reduce preexisting atherosclerosis by enhancing RCT. Female low-density lipoprotein receptor knockout (LDL-R-/- ) mice were fed an atherogenic diet for 3 months, followed by post-treatment with either control or SESO or SOAE for 1 month...
June 29, 2018: Journal of Medicinal Food
Kara Sansone, Mark Kern, Mee Young Hong, Changqi Liu, Shirin Hooshmand
The objective of this study was to assess the potential of dried apple to regulate acute blood glucose, insulin, satiety, and total plasma antioxidant levels, and to explore the effect of dried apple on cognitive responses. Twenty-one healthy, normal-weight subjects completed the study which used a randomized crossover design with repeated measures. After a fast of 10 h, a standardized serving size of either dried apple or muffins was consumed. Blood glucose, insulin, and antioxidant concentrations were measured at 0, 15, 30, 45, 60, 90, and 120 min postprandial, and satiety was assessed every 15 min for 2 h...
June 29, 2018: Journal of Medicinal Food
Rafaela Mazieiro, Renata Reis Frizon, Sandra Maria Barbalho, Ricardo de Alvares Goulart
The inflammatory bowel diseases (IBDs) are mainly represented by Crohn's disease and Ulcerative colitis that are characterized by chronic and relapsing inflammatory processes of the gastrointestinal system. Curcuma longa L. is a plant with several medicinal properties, including anti-inflammatory effects, and curcumin is the most important compound derived from its rhizomes. As curcumin has remarkable anti-inflammatory actions, the aim of this work is to review the potential use of this compound in IBD patients...
June 29, 2018: Journal of Medicinal Food
Soo-Jeung Park, Dasom Lee, Minhee Lee, Han-Ol Kwon, Hyesook Kim, Jeongjin Park, Woojin Jeon, Minseok Cha, Suhwa Jun, Kwangjin Park, Jeongmin Lee
The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leukemia virus (MuLV). Mice were divided into seven groups as follows: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300 mg/kg body weight), the original powder of C...
June 4, 2018: Journal of Medicinal Food
Cong Liu, Weijing Sun, Ning Li, Jiaqi Gao, Chunyan Yu, Chunmei Wang, Jinghui Sun, Shu Jing, Jianguang Chen, He Li
Schisantherin A (SCA) was evaluated for possible function in restoring the learning and memory impairment induced by D-galactose in mice. ICR mice were treated with D-galactose subcutaneously (220 mg·kg-1 ), and followed by SCA in different doses (1.25, 2.50 and 5.00 mg·kg-1 , administered orally) for 42 days. Effects of SCA on learning and memory were examined by step-through tests and Morris water maze tests. The activity of superoxide dismutase (SOD), the content of malondialdehyde (MDA) in the peripheral blood and hippocampus of mice were assayed by water-soluble tetrazolium-1 (WST-1) and thiobarbituric acid (TBA) methods...
May 31, 2018: Journal of Medicinal Food
Juliann Nzembi Makau, Ken Watanabe, Magdy M D Mohammed, Noriyuki Nishida
The high propensity of influenza viruses to develop resistance to antiviral drugs necessitates the continuing search for new therapeutics. Peanut skins, which are low-value byproducts of the peanut industry, are known to contain high levels of polyphenols. In this study, we investigated the antiviral activity of ethanol extracts of peanut skins against various influenza viruses using cell-based assays. Extracts with a higher polyphenol content exhibited higher antiviral activities, suggesting that the active components are the polyphenols...
May 30, 2018: Journal of Medicinal Food
Ruxandra Ştefănescu Braic, Camil Vari, Silvia Imre, Adina Huţanu, Erzsebet Fogarasi, Timea Todea, Alexandra Groşan, Sigrid Eşianu, Eszter Laczkó-Zöld, Maria Dogaru
Antihyperglycemic effects of four extracts obtained from leaves and fruits of Vaccinium myrtillus and Vaccinium corymbosum were assessed in diabetic rats. In addition, the effects of extracts on diabetic-related complications such as the development of diabetic cataract and oxidative stress were evaluated. Type 1 diabetes was induced with a single dose of streptozotocin in Wistar rats. The rats were randomly divided into seven equal groups: NC-normal control, DC-diabetic control, PC-positive control treated with metformin, VML-received V...
May 30, 2018: Journal of Medicinal Food
Suresh Ambati, Colette N Miller, Erica F Bass, Natalie M Hohos, Diane L Hartzell, Emily W Kelso, Emily R Trunnell, Jeong-Yeh Yang, Mary Anne Della-Fera, Clifton A Baile, Srujana Rayalam
Menopause induces a loss of bone as a result of estrogen deficiency. Despite pharmaceutical options for the treatment of osteopenia and osteoporosis, many aging women use dietary supplements with estrogenic activity to prevent bone loss and other menopausal-related symptoms. Such supplements are yet to be tested for efficacy against a Food and Drug Administration (FDA) approved medication for menopausal bone loss such as zoledronic acid (ZA). The postmenopausal rat model was used to investigate the efficacy of various synergistic phytochemical blends mixed into the diet for 16 weeks...
May 24, 2018: Journal of Medicinal Food
Dmitriy Smolensky, Davina Rhodes, D Scott McVey, Zachary Fawver, Ramasamy Perumal, Thomas Herald, Leela Noronha
As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are of significant interest to public health. One such food is sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations of polyphenols. In a panel of 15 sorghum germplasm, we identified strains with higher polyphenol content than previously reported for this grain. Bran extracts from the germplasm with the highest and lowest polyphenol content were then tested against HepG2 and Caco2 cancer cells to assess effects on cancer cell viability, reactive oxygen species, apoptosis, DNA damage, cell cycle arrest, and protein expression patterns...
May 7, 2018: Journal of Medicinal Food
Sergio Davinelli, Graziamaria Corbi, Stefano Righetti, Barry Sears, Hector Hugo Olarte, Davide Grassi, Giovanni Scapagnini
Cardiovascular disease (CVD) remains the leading cause of death today. Many of the biochemical alterations associated with the pathophysiology of CVD can be modified by adequate intakes of bioactive nutrients through a correct diet or supplementation. Recently, there has been growing public and clinical interest in cocoa polyphenols (CPs) and omega-3 (ω-3) fatty acids. A plethora of nutritional intervention trials and experimental studies demonstrates that consumption of these bioactive food compounds is beneficial to promote cardiovascular health...
May 3, 2018: Journal of Medicinal Food
Berat Yangi, Mehmet Cengiz Ustuner, Murat Dincer, Cansu Ozbayer, Neslihan Tekin, Derya Ustuner, Emine Colak, Umut Kerem Kolac, Emre Entok
Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced inflammation in rats. Forty-two, 3- to 4-month-old male Sprague Dawley rats were used in six groups. LPS (1 mg/kg) was administered intraperitoneally to rats in inflammation, inflammation + propolis30, and inflammation+propolis90 groups...
May 2, 2018: Journal of Medicinal Food
Magalli C B Lima E Silva, Danielle Bogo, Caroline A F Alexandrino, Renata T Perdomo, Patrícia de O Figueiredo, Pamela R do Prado, Fernanda R Garcez, Monica C T Kadri, Thalita V N Ximenes, Rita de Cassia A Guimarães, Ulana C Sarmento, Maria Lígia R Macedo
Campomanesia adamantium, a native species of the Brazilian Cerrado, is characterized as a natural source of phenolic compounds and has known potential anticancer activities. This study aimed to evaluate the chemical profile of dichloromethane extracts of pulp (DEGPU) and peel (DEGPE) from the fruits of C. adamantium and to identify compounds with antiproliferative effects in vitro against melanoma cells by sulforhodamine B (SRB) assay, apoptosis induction assay, caspase-3 activation assay, nitric oxide (NO) release in coculture of B16-F10 cells and murine peritoneal macrophages...
May 1, 2018: Journal of Medicinal Food
Wilman Carrillo, Araceli Lucio, Juan Gaibor, Dayana Morales, Grace Vásquez
Native and heated hen egg white lysozyme (HEWL) hydrolysates were isolated by hydrolysis with pepsin at pH 2.0 in situ in a cation exchange membrane to isolate and identify antibacterial peptides of the HEWL hydrolysates. Native and heated HEWL was partially hydrolyzed with pepsin at pH 2.0. The fractions were eluted with 5 M ammonia to identify 23 antibacterial peptides using a tandem mass spectrometry. Then, these fractions were eluted with a solution of NaCl 1 M, and seven positively charged peptides f(23-28) YSLGNW, f(122-129) AWIRGCRL, f(123-129) WIRGCRL, f(124-129) IRGCRL, f(82-96) ALLSSDITASVNCAK, f(103-129) VAWRNRCKGTDVQAWIRGCRL, and f(97-123) KIVSDGNGMNAWVAWRNRCKGT were identified using tandem mass spectrometry...
April 26, 2018: Journal of Medicinal Food
Amanda G Y Chen, Marleen S L Offereins, Christopher J Mulder, Christopher M Frampton, Richard B Gearry
We investigated the impact of the ingestion of two green kiwifruit (Actinidia deliciosa var. Hayward) and one Royal Gala apple on breath hydrogen and methane production in humans. Consumption of two green kiwifruit led to no evidence of carbohydrate malabsorption (0/20), whereas consumption of one apple was associated with carbohydrate malabsorption in 6/20 participants (P = .008). There were no significant differences in the area under the curve for hydrogen or methane breath concentrations after consumption of the two fruits...
April 25, 2018: Journal of Medicinal Food
Ana Lucía Solarte, Rafael Jesús Astorga, Fabiana Carolina de Aguiar, Cristina De Frutos, Belén Barrero-Domínguez, Belén Huerta
To determine the distribution of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of essential oils (EOs) of cinnamon (Cinnamomum zeylanicum), clove (Eugenia caryophyllata), oregano (Origanum vulgare), common thyme (Thymus vulgaris), and red thyme (Thymus zygis) against Salmonella enterica, double serial dilutions of each EO were challenged with 85 Salmonella strains belonging to 23 serotypes of animal origin. The results showed the bactericidal character of the EOs tested against S...
April 24, 2018: Journal of Medicinal Food
Wilman Carrillo, Mercedes Ramos
Hen eggs are a source of bioactive compounds, of which the hen egg white lysozyme (HEWL) protein. HEWL has a demonstrated antibacterial activity. The aim of this study was to evaluate the antimicrobial activity of native and heated HEWL hydrolysates obtained through hydrolysis with pepsin and to identify their peptides using the reversed phase high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (RP-HPLC-ESI-MS-MS) analysis. Native and heat-treated HEWL was hydrolyzed with pepsin at pH 1...
April 24, 2018: Journal of Medicinal Food
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