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Journal of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/28181168/apoa-i-sr-bi-modulates-s1p-s1pr2-mediated-inflammation-through-the-pi3k-akt-signaling-pathway-in-huvecs
#1
Kun Ren, Yan-Ju Lu, Zhong-Cheng Mo, Xing -Liu, Zhen-Li Tang, Yue Jiang, Xiao-Shan Peng, Li Li, Qing-Hai Zhang, Guang-Hui Yi
Endothelial dysfunction plays a vital role during the initial stage of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) induces vascular endothelial injury and vessel wall inflammation. Sphingosine-1-phosphate (S1P) exerts numerous vasoprotective effects by binding to diverse S1P receptors (S1PRs; S1PR1-5). A number of studies have shown that in endothelial cells (ECs), S1PR2 acts as a pro-atherosclerotic mediator by stimulating vessel wall inflammation through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway...
February 8, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28181167/adherence-to-mediterranean-diet-is-associated-with-methylation-changes-in-inflammation-related-genes-in-peripheral-blood-cells
#2
A Arpón, J I Riezu-Boj, F I Milagro, C Razquin, M A Martínez-González, D Corella, R Estruch, R Casas, M Fitó, E Ros, J Salas-Salvadó, J A Martínez
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells...
February 8, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28176184/reviewers-2016
#3
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28160259/protein-malnutrition-during-fetal-programming-induces-fatty-liver-in-adult-male-offspring-rats
#4
Sabrina Edith Campisano, Stella Maris Echarte, Enrique Podaza, Andrea Nancy Chisari
We evaluated the effects of protein malnutrition on liver morphology and physiology in rats subjected to different malnutrition schemes. Pregnant rats were fed with a control diet or a low protein diet (LPD). Male offspring rats received a LPD during gestation, lactation, and until they were 60 days old (MM group), a late LPD that began after weaning (CM), or a LPD administrated only during the gestation-lactation period followed by a control diet (MC). On day 60, blood was collected and the liver was dissected out...
February 3, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28155123/p66shc-mediated-toxicity-of-high-dose-%C3%AE-tocopherol-in-renal-proximal-tubule-cells
#5
Dustin K Reed, Anthony Carter, Mehul Dixit, Istvan Arany
α-Tocopherol (TOC) is a widely used supplement known for its role as an antioxidant. Previously, we have shown that TOC elicits adaptive responses by upregulating the ERK/CREB/HO-1 pathway, which depends on its concentration in cultured renal proximal tubule cells (RPTCs). This suggests that high-dose TOC (hTOC) may elicit adverse effects via inflicting oxidative stress. Since the pro-oxidant p66shc is a major mediator of oxidant injury in various models of renal toxicants, we tested the hypothesis that hTOC elicits renal toxicity through activation of p66shc and consequent oxidative stress...
February 2, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28132394/il-5-blocks-apoptosis-and-tau-hyperphosphorylation-induced-by-a%C3%AE-25-35-peptide-in-pc12-cells
#6
Yuanyuan Zhou, Chaoyan Li, Deheng Li, Yaping Zheng, Jin Wang
The primary features of Alzheimer's disease (AD) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (Aβ) peptides and intracellular neurofibrillary tangles (NFTs). Sets of evidence suggest that interleukin-5 (IL-5) is involved in the pathogenesis of AD. Herein, we investigated the protective role of IL-5 in PC12 cells, to provide new insights into understanding this disease. Western blot was employed to assess the protein levels of Bax and phospho-tau as well as phospho-JAK2; MTT assay was performed to decipher cell viability...
January 28, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28124277/igf-1-modulates-gene-expression-of-proteins-involved-in-inflammation-cytoskeleton-and-liver-architecture
#7
V J Lara-Diaz, I Castilla-Cortazar, I Martín-Estal, M García-Magariño, G A Aguirre, J E Puche, R G de la Garza, L A Morales, U Muñoz
Even though the liver synthesizes most of circulating IGF-1, it lacks its receptor under physiological conditions. However, according to previous studies, a damaged liver expresses the receptor. For this reason, herein, we examine hepatic histology and expression of genes encoding proteins of the cytoskeleton, extracellular matrix, and cell-cell molecules and inflammation-related proteins. A partial IGF-1 deficiency murine model was used to investigate IGF-1's effects on liver by comparing wild-type controls, heterozygous igf1(+/-), and heterozygous mice treated with IGF-1 for 10 days...
January 26, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28110436/contribution-of-inducible-and-neuronal-nitric-oxide-synthases-to-mitochondrial-damage-and-melatonin-rescue-in-lps-treated-mice
#8
José Antonio García, Francisco Ortiz, Javier Miana, Carolina Doerrier, Marisol Fernández-Ortiz, Iryna Rusanova, Germaine Escames, José Joaquín García, Darío Acuña-Castroviejo
NOS isoform activation is related to liver failure during sepsis, but the mechanisms driving mitochondrial impairment remain unclear. We induced sepsis by LPS administration to inducible nitric oxide synthase (iNOS(-/-)) and neuronal nitric oxide synthase (nNOS(-/-)) mice and their respective wild-type controls to examine the contribution of iNOS to mitochondrial failure in the absence of nNOS. To achieve this goal, the determination of messenger RNA (mRNA) expression and protein content of iNOS in cytosol and mitochondria, the mitochondrial respiratory complex content, and the levels of nitrosative and oxidative stress (by measuring 3-nitrotyrosine residues and carbonyl groups, respectively) were examined in the liver of control and septic mice...
January 21, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28074419/deciphering-the-molecular-mechanisms-involved-in-hiv-associated-lipoatrophy-by-transcriptomics-a-pilot-study
#9
Patricia Pérez-Matute, María Iñiguez, Emma Recio-Fernández, José-Antonio Oteo
HIV-associated lipoatrophy (LA) has considerable implications for risk of metabolic diseases, quality of life, and adherence to treatments. Although it has decreased in high-income countries, it is still very common in resource-limited countries. Understanding the pathophysiological mechanisms of LA can open the possibility to explore new ways to treat or prevent this condition. To identify new markers for an accurate and quick diagnosis will be also of interest. Thus, we aimed to examine functional classes of genes implicated in LA and to identify potential new markers for an accurate/quick diagnosis of LA and future complications...
January 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28063097/ideal-cardiovascular-health-and-liver-enzyme-levels-in-european-adolescents-the-helena-study
#10
Idoia Labayen, Jonatan R Ruiz, Inge Huybrechts, Francisco B Ortega, Manuel Castillo, Michael Sjöstrom, Marcela González-Gross, Yannis Manios, Kurt Widhalm, Anthony Kafatos, Christina Breidenassel, Gerardo Rodríguez, Jean Dallongeville, Frédéric Gottrand, Luis A Moreno
There is an increasing interest for the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The American Heart Association (AHA) described the ideal cardiovascular health concept as a score of seven cardiovascular health behaviors and factors that can be used to monitor and predict ideal cardiovascular health over time. This study aimed to examine the association of the ideal cardiovascular health (ICH), as defined by the AHA, with liver enzyme levels in European adolescents. A total of 637 adolescents (54...
January 6, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28012156/sexual-dimorphism-in-obesity-related-genes-in-the-epicardial-fat-during-aging
#11
Caitlin Kocher, Matthew Christiansen, Sarah Martin, Christopher Adams, Paulette Wehner, Todd Gress, Nalini Santanam
Aging increases the risk of cardiovascular disease and metabolic syndrome. Alterations in epicardial fat play an important pathophysiological role in coronary artery disease and hypertension. We investigated the impact of normal aging on obesity-related genes in epicardial fat. Sex-specific changes in obesity-related genes with aging in epicardial fat (EF) were determined in young (6 months) and old (30/36 months) female and male, Fischer 344 × Brown Norway hybrid (FBN) rats, using a rat obesity RT(2) PCR Array...
December 24, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27981508/anti-obesity-effects-of-resveratrol-comparison-between-animal-models-and-humans
#12
Alfredo Fernández-Quintela, Christian Carpéné, Maialen Fernández, Leixuri Aguirre, Iñaki Milton-Laskibar, José Contreras, Maria P Portillo
The prevalence of obesity has increased rapidly during recent years and has reached epidemic proportions. As a result, the scientific community is interested in active biomolecules which are naturally present in plants and foodstuffs and may be useful in body weight management. In recent years, polyphenols have made up one of the most frequently studied groups among these molecules. Numerous studies have been carried out on animals to analyse the potential anti-obesity effects of resveratrol, a non-flavonoid polyphenol, and a general consensus concerning the body-fat-lowering effect of this compound exists...
December 15, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27966196/micrornas-33-122-and-208-a-potential-novel-targets-in-the-treatment-of-obesity-diabetes-and-heart-related-diseases
#13
REVIEW
Osama Abo Alrob, Said Khatib, Saleh A Naser
Despite decades of research, obesity and diabetes remain major health problems in the USA and worldwide. Among the many complications associated with diabetes is an increased risk of cardiovascular diseases, including myocardial infarction and heart failure. Recently, microRNAs have emerged as important players in heart disease and energy regulation. However, little work has investigated the role of microRNAs in cardiac energy regulation. Both human and animal studies have reported a significant increase in circulating free fatty acids and triacylglycerol, increased cardiac reliance on fatty acid oxidation, and subsequent decrease in glucose oxidation which all contributes to insulin resistance and lipotoxicity seen in obesity and diabetes...
December 14, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27933463/effect-of-tempol-and-tempol-plus-catalase-on-intra-renal-haemodynamics-in-spontaneously-hypertensive-stroke-prone-shsp-and-wistar-rats
#14
Ahmad F Ahmeda, Mark G Rae, Mohammed F Al Otaibi, Lamyia M Anweigi, Edward J Johns
Vasoconstriction within the renal medulla contributes to the development of hypertension. This study investigated the role of reactive oxygen species (ROS) in regulating renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar rats. CBP and MBP were measured using a laser-Doppler flow meter before and after intra-renal infusion of tempol, the superoxide dismutase (SOD) mimetic or tempol plus catalase, the hydrogen peroxide-degrading enzyme...
December 9, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27924450/neurobiochemical-and-psychological-factors-influencing-the-eating-behaviors-and-attitudes-in-anorexia-nervosa
#15
REVIEW
Teresa Grzelak, Agata Dutkiewicz, Elzbieta Paszynska, Monika Dmitrzak-Weglarz, Agnieszka Slopien, Marta Tyszkiewicz-Nwafor
The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and behavioral background. Another important issue addressed in the paper is a description of the mechanism leading to continuous dietary restrictions. The altered activity of neurotransmitters modulating patients' moods after the consumption of food and a disturbed responsiveness to enterohormones enhance affective-motivational and cognitive aspects which, in turn, impede the improvement of eating behaviors...
December 6, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27909897/nha2-is-expressed-in-distal-nephron-and-regulated-by-dietary-sodium
#16
Kalyan C Kondapalli, R Todd Alexander, Jennifer L Pluznick, Rajini Rao
Increased renal reabsorption of sodium is a significant risk factor in hypertension. An established clinical marker for essential hypertension is elevated sodium lithium countertransport (SLC) activity. NHA2 is a newly identified Na(+)(Li(+))/H(+) antiporter with potential genetic links to hypertension, which has been shown to mediate SLC activity and H(+)-coupled Na(+)(Li(+)) efflux in kidney-derived MDCK cells. To evaluate a putative role in sodium homeostasis, we determined the effect of dietary salt on NHA2...
December 1, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27637780/increased-urinary-lysophosphatidic-acid-in-mouse-with-subtotal-nephrectomy-potential-involvement-in-chronic-kidney-disease
#17
Koryun Mirzoyan, Anna Baïotto, Aude Dupuy, Dimitri Marsal, Colette Denis, Claire Vinel, Pierre Sicard, Justine Bertrand-Michel, Jean-Loup Bascands, Joost P Schanstra, Julie Klein, Jean-Sébastien Saulnier-Blache
Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipid lysophosphatidic acid (LPA), acting through specific G-protein-coupled receptors, was previously shown to be involved in TIF development in a mouse model of unilateral ureteral obstruction. Here, we study the role of LPA in a mouse subjected to subtotal nephrectomy (SNx), a more chronic and progressive model of CKD...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27604761/lifestyle-predictors-of-oxidant-and-antioxidant-enzyme-activities-and-total-antioxidant-capacity-in-healthy-women-a-cross-sectional-study
#18
Amjad A Mahasneh, Yali Zhang, Hua Zhao, Christine B Ambrosone, Chi-Chen Hong
The aim of this study was to identify demographic and modifiable lifestyle factors that may be related to endogenous oxidant and antioxidant activity measured in blood specimens from putatively healthy women recruited at the Roswell Park Cancer Institute (Buffalo, NY, USA). Total glutathione (TGSH), catalase (CAT), CuZn-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and myeloperoxidase (MPO) activity, and total antioxidant capacity (TAC) were measured in 124 healthy women, and associations with epidemiological factors were tested using general linear models...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27601253/myo-inositol-inhibits-intestinal-glucose-absorption-and-promotes-muscle-glucose-uptake-a-dual-approach-study
#19
Chika Ifeanyi Chukwuma, Mohammed Auwal Ibrahim, Md Shahidul Islam
The present study investigated the effects of myo-inositol on muscle glucose uptake and intestinal glucose absorption ex vivo as well as in normal and type 2 diabetes model of rats. In ex vivo study, both intestinal glucose absorption and muscle glucose uptake were studied in isolated rat jejunum and psoas muscle respectively in the presence of increasing concentrations (2.5 % to 20 %) of myo-inositol. In the in vivo study, the effect of a single bolus dose (1 g/kg bw) of oral myo-inositol on intestinal glucose absorption, blood glucose, gastric emptying and digesta transit was investigated in normal and type 2 diabetic rats after 1 h of co-administration with 2 g/kg bw glucose, when phenol red was used as a recovery marker...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27544228/leucine-supplementation-at-the-onset-of-high-fat-feeding-does-not-prevent-weight-gain-or-improve-glycemic-regulation-in-male-sprague-dawley-rats
#20
Jamie I Baum, Tyrone A Washington, Stephanie A Shouse, Walter Bottje, Sami Dridi, Gina Davis, Dameon Smith
Obesity is a major public health concern and it is essential to identify effective treatments and preventative strategies to stop continued increases in obesity rates. The potential functional roles of the branched chain amino acid leucine make this amino acid an attractive candidate for the treatment and/or prevention of obesity. The objective of this study was to determine if long-term leucine supplementation could prevent the development of obesity and reduce the risk factors for chronic disease in rats fed a high-fat (60 % fat) diet...
December 2016: Journal of Physiology and Biochemistry
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