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Journal of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/29781038/downregulation-of-lncrna-malat1-contributes-to-renal-functional-improvement-after-duodenal-jejunal-bypass-in-a-diabetic-rat-model
#1
Dong Wu, Yu-Gang Cheng, Xin Huang, Ming-Wei Zhong, Shao-Zhuang Liu, San-Yuan Hu
Ameliorated renal function has been reported after bariatric surgery, but the mechanisms underlying this phenomenon are not well-studied. To investigate whether the long non-coding RNA (lncRNA) MALAT1 mediates the amelioration of diabetic nephropathy after duodenal-jejunal bypass (DJB) surgery, rats were assigned randomly into four groups: diabetic (DM) group, DM with DJB surgery group, DM with sham surgery group, and healthy control group. Food intake, body weight, oral glucose tolerance test (OGTT), urine albumin excretion rate (UAER), and glomerular filtration rate (GFR) were measured and histological examination of renal sections was performed...
May 21, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29766441/metabolomic-analysis-and-biochemical-changes-in-the-urine-and-serum-of-streptozotocin-induced-normal-and-obese-diabetic-rats
#2
Ahmed Mediani, Faridah Abas, M Maulidiani, Azliana Abu Bakar Sajak, Alfi Khatib, Chin Ping Tan, Intan Safinar Ismail, Khozirah Shaari, Amin Ismail, N H Lajis
Diabetes mellitus (DM) is a chronic disease that can affect metabolism of glucose and other metabolites. In this study, the normal- and obese-diabetic rats were compared to understand the diabetes disorders of type 1 and 2 diabetes mellitus. This was done by evaluating their urine metabolites using proton nuclear magnetic resonance (1 H NMR)-based metabolomics and comparing with controls at different time points, considering the induction periods of obesity and diabetes. The biochemical parameters of the serum were also investigated...
May 15, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29752707/nmr-metabolomic-study-of-blood-plasma-in-ischemic-and-ischemically-preconditioned-rats-an-increased-level-of-ketone-bodies-and-decreased-content-of-glycolytic-products-24-h-after-global-cerebral-ischemia
#3
Eva Baranovicova, Marian Grendar, Dagmar Kalenska, Anna Tomascova, Daniel Cierny, Jan Lehotsky
Cardiac arrest is one of the leading causes of death among adults in older age. Understanding mechanisms how organism responds to ischemia at global level is essential for the prevention and ischemic patient's treatment. In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death. We also focused on the endogenous phenomenon known as ischemic tolerance by the pre-ischemic treatment...
May 11, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29725909/oral-administration-of-lipid-oil-in-water-emulsions-performed-with-synthetic-or-protein-type-emulsifiers-differentially-affects-post-prandial-triacylglycerolemia-in-rats
#4
Merian Nassra, Christine Bourgeois, Muriel Subirade, Patrick Sauvant, Claude Atgié
In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10 μm diameter) and metastable (3 days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (β-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms...
May 3, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29713940/effects-of-reactive-oxygen-species-and-interplay-of-antioxidants-during-physical-exercise-in-skeletal-muscles
#5
REVIEW
Anand Thirupathi, Ricardo A Pinho
A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. These alterations in the cellular environment seem to occur in an exercise type-dependent manner...
May 1, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29696568/the-relationship-between-adiposopathy-and-glucose-insulin-homeostasis-is-not-affected-by-moderate-intensity-aerobic-training-in-healthy-women-with-obesity
#6
Andrée-Anne Clément, Eléonor Riesco, Sébastien Tessier, Michel Lacaille, Francine Pérusse, Mélanie Coté, Jean-Pierre Després, John Weisnagel, Jean Doré, Denis R Joanisse, Pascale Mauriège
The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m2 ; age, 47-54 years)...
April 26, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29679227/cypd-mptp-axis-regulates-mitochondrial-functions-contributing-to-osteogenic-dysfunction-of-mc3t3-e1-cells-in-inflammation
#7
Xueqi Gan, Ling Zhang, Beilei Liu, Zhuoli Zhu, Yuting He, Junsheng Chen, Junfei Zhu, Haiyang Yu
Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is usually tipped in favor of bone destruction. Evidence suggests that the inflammatory destruction of bone is mainly attributed to oxidative stress and is closely related to mitochondrial dysfunction. The mechanisms underlying osteogenic dysfunction in inflammation still need further investigation...
April 20, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29654511/evidence-for-the-link-between-defective-autophagy-and-inflammation-in-peripheral-blood-mononuclear-cells-of-type-2-diabetic-patients
#8
Samira Alizadeh, Hossein Mazloom, Asie Sadeghi, Solaleh Emamgholipour, Abolfazl Golestani, Farshid Noorbakhsh, Mohsen Khoshniatnikoo, Reza Meshkani
Autophagy was shown to modulate inflammation in immune cells. This study was designed to evaluate the association between autophagy and inflammation in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic (T2D) and non-diabetic (ND) subjects. The autophagy markers were measured by real-time PCR and western blot. The gene expression of pro- and anti-inflammatory cytokines was assessed by real-time PCR. Reduced transcription of BECN1 and LAMP2 and unchanged expression of MAP1LC3B and ATG5 were observed in PBMCs of T2D patients...
April 13, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29654510/mir-128-3p-regulates-3t3-l1-adipogenesis-and-lipolysis-by-targeting-pparg-and-sertad2
#9
Chen Chen, Yuan Deng, Xionggui Hu, Huibo Ren, Ji Zhu, Shengcai Fu, Julan Xie, Yinglin Peng
Differentiation of adipocytes and their aggregation to adipose tissue are critical for mammalian growth and development. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play important roles in adipogenesis and lipid metabolism. miR-128-3p may contribute to adipose tissue development according to the previous studies. However, the role of miR-128-3p in the process of preadipocyte differentiation and lipid metabolism is not yet understood. The purpose of this research was to investigate the biological function and molecular mechanism of miR-128-3p in 3T3-L1 cells...
April 13, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29637446/effect-of-high-chronic-intake-of-sucrose-on-liver-metabolism-in-aging-rats-modulation-by-rutin-and-micronutrients
#10
Eva Gatineau, Frédéric Capel, Dominique Dardevet, Jérémie David, Corinne Pouyet, Sergio Polakof, Laurent Mosoni
High-sugar intake and senescence share common deleterious effects, in particular in liver, but combination of these two factors was little studied. Our aims were to examine the effect of a high-sucrose diet in liver of old rats and also the potential benefices of a polyphenol/micronutrient supplementation. Four groups of 22-month-old male rats fed during 5 months with a diet containing either 13 or 62% sucrose, supplemented or not with rutin, vitamin E, A, D, selenium, and zinc were compared. We measured liver macronutrient composition, glycation/oxidative stress, enzyme activities (lipogenesis, β-oxidation, fructokinase), gene expression (enzymes and transcription factors), in vivo protein synthesis rates and plasma parameters...
April 10, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29611132/modulation-of-diabetes-related-liver-injury-by-the-hmgb1-tlr4-inflammatory-pathway
#11
Sofija Jovanović Stojanov, Vesna Martinović, Desanka Bogojević, Goran Poznanović, Anja Petrović, Svetlana Ivanović-Matić, Ilijana Grigorov
Chronic inflammation plays an essential role in the development of diabetic complications. Understanding the molecular mechanisms that support inflammation is a prerequisite for the design of novel anti-inflammatory therapies. These would take into consideration circulating levels of cytokines and damage-associated molecular patterns (DAMPs) that include the high mobility group box 1 (HMGB1) protein which, in part, promotes the inflammatory response through TLR4 signaling. The liver, as the source of circulating cytokines and acute-phase proteins, contributes to the control of systemic inflammation...
April 2, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29589186/protective-effects-of-mitochondrion-targeted-peptide-ss-31-against-hind-limb-ischemia-reperfusion-injury
#12
Jing Cai, Yu Jiang, Meng Zhang, Hongting Zhao, Huihui Li, Kuanyu Li, Xin Zhang, Tong Qiao
Hind limb ischemia-reperfusion injury is an important pathology in vascular surgery. Reactive oxygen species are thought to be involved in the pathogenesis of hind limb ischemia-reperfusion injury. SS-31, which belongs to a family of mitochondrion-targeted peptide antioxidants, was shown to reduce mitochondrial reactive oxygen species production. In this study, we investigated whether the treatment of SS-31 could protect hind limb from ischemia-reperfusion injury in a mouse model. The results showed that SS-31 treatment either before or after ischemia exhibited similar protective effects...
March 27, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29577176/glutamate-receptors-of-the-a5-region-modulate-cardiovascular-responses-evoked-from-the-dorsomedial-hypothalamic-nucleus-and-perifornical-area
#13
M V López-González, A Díaz-Casares, M González-García, C A Peinado-Aragonés, M A Barbancho, M Carrillo de Albornoz, M S Dawid-Milner
To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30-50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region...
March 26, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29560554/effects-of-exosomes-from-lps-activated-macrophages-on-adipocyte-gene-expression-differentiation-and-insulin-dependent-glucose-uptake
#14
Nicolás De Silva, Mirian Samblas, J Alfredo Martínez, Fermín I Milagro
Obesity is usually associated with low-grade inflammation, which determines the appearance of comorbidities like atherosclerosis and insulin resistance. Infiltrated macrophages in adipose tissue are partly responsible of this inflammatory condition. Numerous studies point to the existence of close intercommunication between macrophages and adipocytes and pay particular attention to the proinflammatory cytokines released by both cell types. However, it has been recently described that in both, circulation and tissue level, there are extracellular vesicles (including microvesicles and exosomes) containing miRNAs, mRNAs, and proteins that can influence the inflammatory response...
March 20, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29541948/protective-effect-of-the-total-flavonoids-from-apocynum-venetum-l-on-carbon-tetrachloride-induced-hepatotoxicity-in-vitro-and-in-vivo
#15
Wei Zhang, Zheng Dong, Xiujuan Chang, Cuihong Zhang, Guanghua Rong, Xudong Gao, Zhen Zeng, Chunping Wang, Yan Chen, Yihui Rong, Jianhui Qu, Ze Liu, Yinying Lu
Apocynum venetum L., belonging to the family Apocynaceae, is a popular medicinal plant, which is commonly used in the treatment of hypertension, neurasthenia, and hepatitis in China. In the present study, the total flavonoids (TFs) were prepared from the leaves of A. venetum, and its protective effects on carbon tetrachloride (CCl4 )-induced hepatotoxicity in a cultured HepG2 cell line and in mice were investigated. Cell exposed to 0.4% CCl4 (v/v) for 6 h led to a significant decrease in cell viability, increased LDH leakage, and intracellular reactive oxygen species (ROS)...
March 14, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29541947/natural-antioxidants-in-prevention-of-accelerated-ageing-a-departure-from-conventional-paradigms-required
#16
Carine Smith
The modern lifestyle is characterised by various factors that cause accelerating ageing by the upregulation of oxidative stress and inflammation-two processes that are inextricably linked in an endless circle of self-propagation. Inflammation in particular is commonly accepted as aetiological factor in many chronic disease states, such as obesity, diabetes and depression. In terms of disease prevention or treatment, interventions aimed at changing dietary and/or exercise habits have had limited success in practise, mostly due to poor long-term compliance...
March 14, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29526026/cxcl5-regulation-of-proliferation-and-migration-in-human-non-small-cell-lung-cancer-cells
#17
Lin Wang, Lin Shi, Jie Gu, Cheng Zhan, Junjie Xi, Jianyong Ding, Di Ge
Epithelial neutrophil-activating peptide-78 (CXCL5), a member of the subgroup of CXC-type chemokine family, is an inflammatory factor involved in the progression of lung cancer, but the underlying mechanism remains unclear. In this study, we investigated the effects of CXCL5 on proliferation and migration in non-small cell lung cancer (NSCLC) using tissue microarrays from NSCLC patients and H460 cells transfected with a CXCL5-interfered lentivirus vector or stimulated with recombinant CXCL5. We observed that the expression of CXCL5 was significantly higher in lung cancer cell lines, and high CXCL5 was associated with high chemokine (C-X-C motif) receptor 2 expression and was significantly associated with poor differentiation...
March 10, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29520661/sceletium-tortuosum-may-delay-chronic-disease-progression-via-alkaloid-dependent-antioxidant-or-anti-inflammatory-action
#18
A C Bennett, A Van Camp, V López, C Smith
The link between obesity-induced systemic inflammation and decreased insulin signalling is well-known. It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxins that can ultimately lead to the demise of central nervous system integrity. A high-mesembrine Sceletium tortuosum extract was recently shown to possess cytoprotective and mild anti-inflammatory properties in monocytes and to target specific p450 enzymes to reduce adrenal glucocorticoid synthesis...
March 9, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29512021/the-protective-effects-of-metformin-in-an-in-vitro-model-of-aging-3t3-fibroblast-under-the-high-glucose-conditions
#19
Tugba Soydas, Elif Yaprak Sarac, Suzan Cinar, Sibel Dogan, Seyhun Solakoglu, Matem Tuncdemir, Gonul Kanigur Sultuybek
Metformin is the most widely used anti-diabetic drug in the world. It reduces advanced glycation end product (AGEs)-induced ROS generation in high glucose condition. Protein glycation contributes to skin aging as it deteriorates the existing collagen by crosslinking. The progressive increase of AGE during aging not only causes oxidative damage to cellular macromolecules but also modulates the activation of transcription factors nuclear factor kappa-B(NF-kB). However, it is still unclear whether metformin can change collagen production and NF-kB activity induced by high glucose conditions in 3T3 fibroblast...
March 6, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29478123/physical-exercise-mitigates-high-fat-diet-induced-adiposopathy-and-related-endocrine-alterations-in-an-animal-model-of-obesity
#20
Sílvia Rocha-Rodrigues, Inês O Gonçalves, Jorge Beleza, António Ascensão, José Magalhães
The dysregulation of adipokine secretion owing to adiposopathy can contribute to the pathogenesis of obesity-related disorders. Being that exercise is an advised strategy against obesity-induced adiposopathy, we aimed to analyze the role of physical exercise as a preventive and therapeutic strategy against high-fat diet (HFD)-induced adipokine and ghrelin alterations. Rats were pair-fed the Lieber De Carli standard diet (S, 35 Kcal% fat) or HFD (71 Kcal% fat) over 17 weeks. Animals were assigned into four groups as follows: standard diet sedentary (SS), standard diet voluntary physical activity (SVPA), high-fat diet sedentary (HS), and high-fat diet voluntary physical activity (HVPA)...
February 24, 2018: Journal of Physiology and Biochemistry
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