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Journal of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/30019185/cathepsin-b-inhibition-ameliorates-the-non-alcoholic-steatohepatitis-through-suppressing-caspase-1-activation
#1
Yong Tang, Guojun Cao, Xiaobo Min, Tao Wang, Shiran Sun, Xiaolong Du, Weikang Zhang
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease. NLRP3 inflammasome activation has been widely studied in the pathogenesis of NAFLD. Cathepsin B (CTSB) is a ubiquitous cysteine cathepsin, and the role of CTSB in the progression and development of NAFLD has received extensive concern. However, the exact roles of CTSB in the NAFLD development and NLRP3 inflammasome activation are yet to be evaluated. In the present study, we used methionine choline-deficient (MCD) diet to establish mice NASH model...
July 17, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30006781/mir-9-inhibits-the-metastatic-ability-of-hepatocellular-carcinoma-via-targeting-beta-galactoside-alpha-2-6-sialyltransferase-1
#2
Yi Han, Yubo Liu, Xirao Fu, Qi Zhang, Huang Huang, Cheng Zhang, Wenli Li, Jianing Zhang
Glycosylation of cell surface proteins regulates critical cellular functions, including invasion and metastasis in cancer cells. Emerging evidence has shown that microRNAs (miRNAs) are involved in regulating both the glycosylation modifications on cell surface and the progression of cancer. In this study, we investigated the role of miR-9 in α-2,6-linked sialylation and the metastasis of mouse hepatocellular carcinoma (HCC). According to array-based miRNA expression profiling data of HCC cell lines Hepa1-6, Hca-P, and Hca-F with different lymphatic metastatic capacities, reverse correlation was found between miR-9 expression levels and the metastatic potential in these HCC cells...
July 13, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29916179/changes-in-the-activity-of-some-metabolic-enzymes-in-the-heart-of-shr-rat-incurred-by-transgenic-expression-of-cd36
#3
Dmitry Manakov, David Kolar, Jitka Zurmanova, Michal Pravenec, Jiri Novotny
Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat (SHR) can be alleviated by rescuing CD36 fatty acid translocase. The present study investigated whether transgenic rescue of CD36 in SHR could affect mitochondrial function and activity of selected metabolic enzymes in the heart. These analyses were conducted on ventricular preparations derived from SHR and from transgenic strain SHR-Cd36 that expresses a functional wild-type CD36. Our respirometric measurements revealed that mitochondria isolated from the left ventricles exhibited two times higher respiratory activity than those isolated from the right ventricles...
June 18, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29948786/fps-zm1-and-valsartan-combination-protects-better-against-glomerular-filtration-barrier-damage-in-streptozotocin-induced-diabetic-rats
#4
Davoud Sanajou, Amir Ghorbani Haghjo, Hassan Argani, Leila Roshangar, Saeed Nazari Soltan Ahmad, Zahra Ashrafi Jigheh, Somayeh Aslani, Fatemeh Panah, Jalil Rashedi, Mehran Mesgari Abbasi
Despite the effectiveness of renin-angiotensin blockade in retarding diabetic nephropathy progression, a considerable number of patients still develop end-stage renal disease. The present investigation aims to evaluate the protective potential of FPS-ZM1, a selective inhibitor of receptor for advanced glycation end products (RAGE), alone and in combination with valsartan, an angiotensin receptor blocker, against glomerular injury parameters in streptozotocin-induced diabetic rats. FPS-ZM1 at 1 mg/kg (i.p.), valsartan at 100 mg/kg (p...
June 14, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29882093/voluntary-exercise-opposes-insulin-resistance-of-skeletal-muscle-glucose-transport-during-liquid-fructose-ingestion-in-rats
#5
Yupaporn Rattanavichit, Jariya Buniam, Juthamard Surapongchai, Vitoon Saengsirisuwan
We have recently reported that male rats given liquid fructose ingestion exhibit features of cardiometabolic abnormalities including non-obese insulin resistance with impaired insulin signaling transduction in skeletal muscle (Rattanavichit Y et al. Am J Physiol Regul Integr Comp Physiol 311: R1200-R1212, 2016). While exercise can attenuate obesity-related risks of cardiometabolic syndrome, the effectiveness and potential mechanism by which exercise modulates non-obese insulin resistance have not been fully studied...
June 7, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29869069/ptrf-acts-as-an-adipokine-contributing-to-adipocyte-dysfunctionality-and-ectopic-lipid-deposition
#6
Sergio Perez-Diaz, Maria P Garcia-Sobreviela, Yolanda Gonzalez-Irazabal, Beatriz Garcia-Rodriguez, Silvia Espina, Izaskun Arenaz, Jose M Arbones-Mainar
Adipose tissue (AT) expands under obesogenic conditions. Yet, when the growth exceeds a certain limit, AT becomes dysfunctional and surplus lipids start depositing ectopically. Polymerase I and transcription release factor (PTRF) has been proposed as a mechanism leading to a dysfunctional AT by decreasing the adipogenic potential of human adipocyte precursors. However, whether or not PTRF can be secreted by the adipocytes into the bloodstream is not yet known. For this work, PTRF presence was investigated in plasma...
June 4, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29797227/physical-training-improves-thermogenesis-and-insulin-pathway-and-induces-remodeling-in-white-and-brown-adipose-tissues
#7
Maria Andrea Barbosa, Renata Guerra-Sá, Uberdan Guilherme Mendes De Castro, Wanderson Geraldo de Lima, Robson Augusto Souza Dos Santos, Maria José Campagnole-Santos, Andréia Carvalho Alzamora
Physical training (PT) has been considered as a treatment in metabolic syndrome (MS), since it induces thermogenic activity in brown (BAT) and white (WAT) adipose tissues. We evaluated the therapeutic effect of PT on activity of WAT and BAT in rats with MS induced by high-fat diet (30% lard) for 13 weeks and submitted, for the last 6 weeks, to swimming or kept sedentary (SED) rats. MS-SED rats compared to control diet (CT-SED) rats showed low physical fitness and high levels of glucose, insulin, homeostasis evaluation of insulin resistance (HOMA-IR), homeostasis evaluation of the functional capacity of β-cells (HOMA-β), and blood pressure...
May 25, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29790117/regulatory-roles-of-mir-155-and-let-7b-on-the-expression-of-inflammation-related-genes-in-thp-1-cells-effects-of-fatty-acids
#8
J L Marques-Rocha, M Garcia-Lacarte, M Samblas, J Bressan, J A Martínez, F I Milagro
The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h...
May 22, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29781038/downregulation-of-lncrna-malat1-contributes-to-renal-functional-improvement-after-duodenal-jejunal-bypass-in-a-diabetic-rat-model
#9
Dong Wu, Yu-Gang Cheng, Xin Huang, Ming-Wei Zhong, Shao-Zhuang Liu, San-Yuan Hu
Ameliorated renal function has been reported after bariatric surgery, but the mechanisms underlying this phenomenon are not well-studied. To investigate whether the long non-coding RNA (lncRNA) MALAT1 mediates the amelioration of diabetic nephropathy after duodenal-jejunal bypass (DJB) surgery, rats were assigned randomly into four groups: diabetic (DM) group, DM with DJB surgery group, DM with sham surgery group, and healthy control group. Food intake, body weight, oral glucose tolerance test (OGTT), urine albumin excretion rate (UAER), and glomerular filtration rate (GFR) were measured and histological examination of renal sections was performed...
May 21, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29766441/metabolomic-analysis-and-biochemical-changes-in-the-urine-and-serum-of-streptozotocin-induced-normal-and-obese-diabetic-rats
#10
Ahmed Mediani, Faridah Abas, M Maulidiani, Azliana Abu Bakar Sajak, Alfi Khatib, Chin Ping Tan, Intan Safinar Ismail, Khozirah Shaari, Amin Ismail, N H Lajis
Diabetes mellitus (DM) is a chronic disease that can affect metabolism of glucose and other metabolites. In this study, the normal- and obese-diabetic rats were compared to understand the diabetes disorders of type 1 and 2 diabetes mellitus. This was done by evaluating their urine metabolites using proton nuclear magnetic resonance (1 H NMR)-based metabolomics and comparing with controls at different time points, considering the induction periods of obesity and diabetes. The biochemical parameters of the serum were also investigated...
May 15, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29752707/nmr-metabolomic-study-of-blood-plasma-in-ischemic-and-ischemically-preconditioned-rats-an-increased-level-of-ketone-bodies-and-decreased-content-of-glycolytic-products-24-h-after-global-cerebral-ischemia
#11
Eva Baranovicova, Marian Grendar, Dagmar Kalenska, Anna Tomascova, Daniel Cierny, Jan Lehotsky
Cardiac arrest is one of the leading causes of death among adults in older age. Understanding mechanisms how organism responds to ischemia at global level is essential for the prevention and ischemic patient's treatment. In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death. We also focused on the endogenous phenomenon known as ischemic tolerance by the pre-ischemic treatment...
May 11, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29725909/oral-administration-of-lipid-oil-in-water-emulsions-performed-with-synthetic-or-protein-type-emulsifiers-differentially-affects-post-prandial-triacylglycerolemia-in-rats
#12
Merian Nassra, Christine Bourgeois, Muriel Subirade, Patrick Sauvant, Claude Atgié
In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10 μm diameter) and metastable (3 days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (β-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms...
May 3, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29713940/effects-of-reactive-oxygen-species-and-interplay-of-antioxidants-during-physical-exercise-in-skeletal-muscles
#13
REVIEW
Anand Thirupathi, Ricardo A Pinho
A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. These alterations in the cellular environment seem to occur in an exercise type-dependent manner...
May 1, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29696568/the-relationship-between-adiposopathy-and-glucose-insulin-homeostasis-is-not-affected-by-moderate-intensity-aerobic-training-in-healthy-women-with-obesity
#14
Andrée-Anne Clément, Eléonor Riesco, Sébastien Tessier, Michel Lacaille, Francine Pérusse, Mélanie Coté, Jean-Pierre Després, John Weisnagel, Jean Doré, Denis R Joanisse, Pascale Mauriège
The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m2 ; age, 47-54 years)...
April 26, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29611132/modulation-of-diabetes-related-liver-injury-by-the-hmgb1-tlr4-inflammatory-pathway
#15
Sofija Jovanović Stojanov, Vesna Martinović, Desanka Bogojević, Goran Poznanović, Anja Petrović, Svetlana Ivanović-Matić, Ilijana Grigorov
Chronic inflammation plays an essential role in the development of diabetic complications. Understanding the molecular mechanisms that support inflammation is a prerequisite for the design of novel anti-inflammatory therapies. These would take into consideration circulating levels of cytokines and damage-associated molecular patterns (DAMPs) that include the high mobility group box 1 (HMGB1) protein which, in part, promotes the inflammatory response through TLR4 signaling. The liver, as the source of circulating cytokines and acute-phase proteins, contributes to the control of systemic inflammation...
May 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29589186/protective-effects-of-mitochondrion-targeted-peptide-ss-31-against-hind-limb-ischemia-reperfusion-injury
#16
Jing Cai, Yu Jiang, Meng Zhang, Hongting Zhao, Huihui Li, Kuanyu Li, Xin Zhang, Tong Qiao
Hind limb ischemia-reperfusion injury is an important pathology in vascular surgery. Reactive oxygen species are thought to be involved in the pathogenesis of hind limb ischemia-reperfusion injury. SS-31, which belongs to a family of mitochondrion-targeted peptide antioxidants, was shown to reduce mitochondrial reactive oxygen species production. In this study, we investigated whether the treatment of SS-31 could protect hind limb from ischemia-reperfusion injury in a mouse model. The results showed that SS-31 treatment either before or after ischemia exhibited similar protective effects...
May 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29577176/glutamate-receptors-of-the-a5-region-modulate-cardiovascular-responses-evoked-from-the-dorsomedial-hypothalamic-nucleus-and-perifornical-area
#17
M V López-González, A Díaz-Casares, M González-García, C A Peinado-Aragonés, M A Barbancho, M Carrillo de Albornoz, M S Dawid-Milner
To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30-50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region...
May 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29541948/protective-effect-of-the-total-flavonoids-from-apocynum-venetum-l-on-carbon-tetrachloride-induced-hepatotoxicity-in-vitro-and-in-vivo
#18
Wei Zhang, Zheng Dong, Xiujuan Chang, Cuihong Zhang, Guanghua Rong, Xudong Gao, Zhen Zeng, Chunping Wang, Yan Chen, Yihui Rong, Jianhui Qu, Ze Liu, Yinying Lu
Apocynum venetum L., belonging to the family Apocynaceae, is a popular medicinal plant, which is commonly used in the treatment of hypertension, neurasthenia, and hepatitis in China. In the present study, the total flavonoids (TFs) were prepared from the leaves of A. venetum, and its protective effects on carbon tetrachloride (CCl4 )-induced hepatotoxicity in a cultured HepG2 cell line and in mice were investigated. Cell exposed to 0.4% CCl4 (v/v) for 6 h led to a significant decrease in cell viability, increased LDH leakage, and intracellular reactive oxygen species (ROS)...
May 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29526026/cxcl5-regulation-of-proliferation-and-migration-in-human-non-small-cell-lung-cancer-cells
#19
Lin Wang, Lin Shi, Jie Gu, Cheng Zhan, Junjie Xi, Jianyong Ding, Di Ge
Epithelial neutrophil-activating peptide-78 (CXCL5), a member of the subgroup of CXC-type chemokine family, is an inflammatory factor involved in the progression of lung cancer, but the underlying mechanism remains unclear. In this study, we investigated the effects of CXCL5 on proliferation and migration in non-small cell lung cancer (NSCLC) using tissue microarrays from NSCLC patients and H460 cells transfected with a CXCL5-interfered lentivirus vector or stimulated with recombinant CXCL5. We observed that the expression of CXCL5 was significantly higher in lung cancer cell lines, and high CXCL5 was associated with high chemokine (C-X-C motif) receptor 2 expression and was significantly associated with poor differentiation...
May 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29512021/the-protective-effects-of-metformin-in-an-in-vitro-model-of-aging-3t3-fibroblast-under-the-high-glucose-conditions
#20
Tugba Soydas, Elif Yaprak Sarac, Suzan Cinar, Sibel Dogan, Seyhun Solakoglu, Matem Tuncdemir, Gonul Kanigur Sultuybek
Metformin is the most widely used anti-diabetic drug in the world. It reduces advanced glycation end product (AGEs)-induced ROS generation in high glucose condition. Protein glycation contributes to skin aging as it deteriorates the existing collagen by crosslinking. The progressive increase of AGE during aging not only causes oxidative damage to cellular macromolecules but also modulates the activation of transcription factors nuclear factor kappa-B(NF-kB). However, it is still unclear whether metformin can change collagen production and NF-kB activity induced by high glucose conditions in 3T3 fibroblast...
May 2018: Journal of Physiology and Biochemistry
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