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Journal of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/28730509/effect-of-a-2000-m-running-test-on-antioxidant-and-cytokine-response-in-plasma-and-circulating-cells
#1
Lucrecia Carrera-Quintanar, Lorena Funes, Miguel Sánchez-Martos, Pascual Martinez-Peinado, José M Sempere, Antoni Pons, Vicente Micol, Enrique Roche
Exercise intensity usually correlates with increased oxidative stress and enhanced cytokine production. However, it is unknown if all types of exercise that induce muscle damage can cause a parallel response in the oxidation balance and cytokine production. To this end, the effect of a 2000-m running test in a group of volunteers that regularly train in aerobic routines was studied. Different circulating parameters were measured, oxidative stress markers (protein carbonyls and malondialdehyde), antioxidant enzyme activity, and cytokine levels in plasma as well as in the main circulating cells of blood samples obtained in basal conditions and after test execution...
July 20, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28707280/multi-regulatory-network-of-ros-the-interconnection-of-ros-pgc-1-alpha-and-ampk-sirt1-during-exercise
#2
REVIEW
Anand Thirupathi, Claudio Teodoro de Souza
Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet...
July 14, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28707279/sarcolipin-expression-is-repressed-by-endoplasmic-reticulum-stress-in-c2c12-myotubes
#3
Nobuhiko Takahashi, Atsushi P Kimura, Sumiyoshi Naito, Mika Yoshida, Osamu Kumano, Takeshi Suzuki, Satoshi Itaya, Mitsuru Moriya, Masahiro Tsuji, Masahiro Ieko
Sarcolipin is a transmembrane protein expressed in the sarco/endoplasmic reticulum of skeletal and atrial muscles in large animals. Sarcolipin plays crucial roles in heat production through modifying the function of sarco/endoplasmic reticulum Ca(2+) ATPase, thereby being involved in thermogenesis and systemic metabolism. In skeletal muscle, endoplasmic reticulum (ER) stress has been implicated in several conditions, such as insulin resistance, muscle diseases, and hypo/hyper-contraction. Here, we investigated the effect of ER stress on sarcolipin expression in skeletal muscle cells, C2C12 myotubes...
July 13, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28695466/oxidative-stress-dependent-contribution-of-hmgb1-to-the-interplay-between-apoptosis-and-autophagy-in-diabetic-rat-liver
#4
Anja Petrović, Desanka Bogojević, Aleksandra Korać, Igor Golić, Sofija Jovanović-Stojanov, Vesna Martinović, Svetlana Ivanović-Matić, Jelena Stevanović, Goran Poznanović, Ilijana Grigorov
The progression of oxidative stress, resulting cell damage, and cell death underlies the etiology of liver damage/dysfunction as a complication of diabetes. High-mobility group box 1 (HMGB1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and signaling pathways regulating cell death and cell survival. We previously found that in streptozotocin (STZ)-induced diabetic rats, reduction of oxidative stress after melatonin administration lowered necrotic cell death and increased expression of HMGB1 and hepatocellular damage...
July 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28677073/in-vitro-evaluation-of-the-prebiotic-effect-of-red-and-white-grape-polyphenolic-extracts
#5
S Rodríguez-Costa, A Cardelle-Cobas, P Roca-Saavedra, J J Porto-Arias, J M Miranda, A Cepeda
Nowadays, the strong relationship between diet and health is well known. Although the primary role of diet is to provide nutrients to fulfill metabolic requirements, the use of foods to improve health and the state of well-being is an idea increasingly accepted by society in the last three decades. During the last years, an important number of scientific advances have been achieved in this field and, although in some situations, it is difficult to establish a distinction between "harmful" and "good" bacteria, experts agree in classifying the genera Bifidobacterium and Lactobacillus as beneficial bacteria...
July 4, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28624934/low-serum-diamine-oxidase-dao-activity-levels-in-patients-with-migraine
#6
Joan Izquierdo-Casas, Oriol Comas-Basté, M Luz Latorre-Moratalla, Marian Lorente-Gascón, Adriana Duelo, M Carmen Vidal-Carou, Luis Soler-Singla
Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multi-faced symptoms associated with histamine intolerance, headache is one of the most recognized and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects...
June 17, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28624933/influence-of-food-consumption-patterns-and-galician-lifestyle-on-human-gut-microbiota
#7
María Castro-Penalonga, Paula Roca-Saavedra, Jose Manuel Miranda, Jose Julio Porto-Arias, Carolina Nebot, Alejandra Cardelle-Cobas, Carlos Manuel Franco, Alberto Cepeda
The proportion of different microbial populations in the human gut is an important factor that in recent years has been linked to obesity and numerous metabolic diseases. Because there are many factors that can affect the composition of human gut microbiota, it is of interest to have information about what is the composition of the gut microbiota in different populations in order to better understand the possibilities for improving nutritional management. A group of 31 volunteers were selected according to established inclusion and exclusion criteria and were asked about their diet history, lifestyle patterns, and adherence to the Southern European Atlantic Diet...
June 17, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28612196/cell-source-differentiation-functional-stimulation-and-potential-application-of-human-thermogenic-adipocytes-in-vitro
#8
REVIEW
Dinh-Toi Chu, Yang Tao, Le Hoang Son, Duc-Hau Le
Recent investigations have showed that the functional thermogenic adipocytes are present in both infants and adult humans. Accumulating evidence suggests that the coexistence of classical and inducible brown (brite) adipocytes in humans at adulthood and these adipocytes function to generate heat from energy resulting in reducing body fat and improving glucose metabolism. Human thermogenic adipocytes can be differentiated in vitro from stem cells, cell lines, or adipose stromal vascular fraction. Pre-activated human brite adipocytes in vitro can maintain their thermogenic function in normal or obese immunodeficient mice; therefore, they improve glucose homeostasis and reduce fat mass in obese animals...
June 14, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28600747/sodium-butyrate-protects-against-oxidative-stress-in-hepg2-cells-through-modulating-nrf2-pathway-and-mitochondrial-function
#9
Xingan Xing, Zheshu Jiang, Xue Tang, Panpan Wang, Yingrui Li, Yongjuan Sun, Guowei Le, Sixiang Zou
Sodium butyrate (NaBu) is a by-product of microbial fermentation of dietary fiber in the gastrointestinal tract and has been shown to increase the activity of antioxidant enzymes, such as catalase or heme oxidase-1, in vivo. However, the mechanism of this effect is still unclear. This study investigated the antioxidant effect of NaBu on HepG2 cells under H2O2-induced oxidative stress. NaBu (0.3 mM) attenuated cell death and accumulation of reactive oxygen species and improved multiple antioxidant parameters in H2O2-injured HepG2 cells...
June 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28600746/dopamine-induces-inhibitory-effects-on-the-circular-muscle-contractility-of-mouse-distal-colon-via-d1-and-d2-like-receptors
#10
Michelangelo Auteri, Maria Grazia Zizzo, Antonella Amato, Rosa Serio
Dopamine (DA) acts as gut motility modulator, via D1- and D2-like receptors, but its effective role is far from being clear. Since alterations of the dopaminergic system could lead to gastrointestinal dysfunctions, a characterization of the enteric dopaminergic system is mandatory. In this study, we investigated the role of DA and D1- and D2-like receptors in the contractility of the circular muscle of mouse distal colon by organ-bath technique. DA caused relaxation in carbachol-precontracted circular muscle strips, sensitive to domperidone, D2-like receptor antagonist, and mimicked by bromocriptine, D2-like receptor agonist...
June 9, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28589533/effects-of-exendin-4-and-selenium-on-the-expression-of-glp-1r-irs-1-and-preproinsulin-in-the-pancreas-of-diabetic-rats
#11
Ghinwa Barakat, Mohamed E Moustafa, Ibrahim Khalifeh, Mohammad H Hodroj, Anwar Bikhazi, Sandra Rizk
The mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and preproinsulin in the pancreas of diabetic rats. Diabetes was induced by streptozotocin administration. Diabetic rats were injected intraperitoneally with 0.03 μg exendin-4/kg body weight/daily or treated with 5 ppm selenium in drinking water for a period of 4 weeks...
June 7, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28555332/protective-role-of-downregulated-mlk3-in-myocardial-adaptation-to-chronic-hypoxia
#12
Siyi He, Shunbi Liu, Xiaochen Wu, Mei Xin, Sheng Ding, Dong Xin, Hui Ouyang, Jinbao Zhang
A series of protective responses could be evoked to achieve compensatory adaptation once cardiomyocytes are subjected to chronic hypoxia. MLK3/JNK/c-jun signaling pathway was previously demonstrated to be involved in this process. In the present study, we aim to further examine the performance of MLK3 in hypoxic H9C2 cells and potential mechanism. Myocardial samples of patients with congenital heart disease (CHD) were collected. H9C2 cells were cultured in hypoxic conditions for various durations. MLK3 was silenced by transfection of shRNA to evaluate its role in cell viability...
May 30, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28488210/food-additives-contaminants-and-other-minor-components-effects-on-human-gut-microbiota-a-review
#13
REVIEW
Paula Roca-Saavedra, Veronica Mendez-Vilabrille, Jose Manuel Miranda, Carolina Nebot, Alejandra Cardelle-Cobas, Carlos M Franco, Alberto Cepeda
Gut bacteria play an important role in several metabolic processes and human diseases, such as obesity and accompanying co-morbidities, such as fatty liver disease, insulin resistance/diabetes, and cardiovascular events. Among other factors, dietary patterns, probiotics, prebiotics, synbiotics, antibiotics, and non-dietary factors, such as stress, age, exercise, and climatic conditions, can dramatically impact the human gut microbiota equilibrium and diversity. However, the effect of minor food constituents, including food additives and trace contaminants, on human gut microbiota has received less attention...
May 9, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28470555/cgrp-8-37-enhances-lipopolysaccharide-induced-acute-lung-injury-and-regulating-aquaporin-1-and-5-expressions-in-rats
#14
Fu Hong-Min, Huangfu Chun-Rong, Zheng Rui, Su Li-Na, Wang Ya-Jun, Li Li
Calcitonin gene-related peptide (CGRP) has been shown to play important roles in biological functions. However, there is very little evidence on the value of CGRP in lipopolysaccharide (LPS)-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Therefore, this study aimed to investigate the role of CGRP in LPS-induced ALI in rats. In the experiment, Sprague-Dawley (SD) rats were randomized into control, an antagonist of α-calcitonin gene-related peptide receptor (CGRP8-37), LPS groups, and CGRP8-37 + LPS groups...
May 4, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28124277/igf-1-modulates-gene-expression-of-proteins-involved-in-inflammation-cytoskeleton-and-liver-architecture
#15
V J Lara-Diaz, I Castilla-Cortazar, I Martín-Estal, M García-Magariño, G A Aguirre, J E Puche, R G de la Garza, L A Morales, U Muñoz
Even though the liver synthesizes most of circulating IGF-1, it lacks its receptor under physiological conditions. However, according to previous studies, a damaged liver expresses the receptor. For this reason, herein, we examine hepatic histology and expression of genes encoding proteins of the cytoskeleton, extracellular matrix, and cell-cell molecules and inflammation-related proteins. A partial IGF-1 deficiency murine model was used to investigate IGF-1's effects on liver by comparing wild-type controls, heterozygous igf1(+/-), and heterozygous mice treated with IGF-1 for 10 days...
May 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27924450/neurobiochemical-and-psychological-factors-influencing-the-eating-behaviors-and-attitudes-in-anorexia-nervosa
#16
REVIEW
Teresa Grzelak, Agata Dutkiewicz, Elzbieta Paszynska, Monika Dmitrzak-Weglarz, Agnieszka Slopien, Marta Tyszkiewicz-Nwafor
The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and behavioral background. Another important issue addressed in the paper is a description of the mechanism leading to continuous dietary restrictions. The altered activity of neurotransmitters modulating patients' moods after the consumption of food and a disturbed responsiveness to enterohormones enhance affective-motivational and cognitive aspects which, in turn, impede the improvement of eating behaviors...
May 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27909897/nha2-is-expressed-in-distal-nephron-and-regulated-by-dietary-sodium
#17
Kalyan C Kondapalli, R Todd Alexander, Jennifer L Pluznick, Rajini Rao
Increased renal reabsorption of sodium is a significant risk factor in hypertension. An established clinical marker for essential hypertension is elevated sodium lithium countertransport (SLC) activity. NHA2 is a newly identified Na(+)(Li(+))/H(+) antiporter with potential genetic links to hypertension, which has been shown to mediate SLC activity and H(+)-coupled Na(+)(Li(+)) efflux in kidney-derived MDCK cells. To evaluate a putative role in sodium homeostasis, we determined the effect of dietary salt on NHA2...
May 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28357578/effect-of-fatty-acid-interaction-on-myoglobin-oxygen-affinity-and-triglyceride-metabolism
#18
Thomas Jue, Gregory Simond, Traver J Wright, Lifan Shih, Youngran Chung, Renuka Sriram, Ulrike Kreutzer, Randall W Davis
Recent studies have suggested myoglobin (Mb) may have other cellular functions in addition to storing and transporting O2. Indeed, NMR experiments have shown that the saturated fatty acid (FA) palmitate (PA) can interact with myoglobin (Mb) in its ligated state (MbCO and MbCN) but does not interact with Mb in its deoxygenated state. The observation has led to the hypothesis that Mb can also serve as a fatty acid transporter. The present study further investigates fatty acid interaction with the physiological states of Mb using the more soluble but unsaturated fatty acid, oleic acid (OA)...
March 29, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28353150/gene-methylation-parallelisms-between-peripheral-blood-cells-and-oral-mucosa-samples-in-relation-to-overweight
#19
Rodrigo San-Cristobal, Santiago Navas-Carretero, Fermín I Milagro, J Ignacio Riezu-Boj, Elizabeth Guruceaga, Carlos Celis-Morales, Katherine M Livingstone, Lorraine Brennan, Julie A Lovegrove, Hannelore Daniel, Wim H Saris, Iwonna Traczyk, Yannis Manios, Eileen R Gibney, Michael J Gibney, John C Mathers, J Alfredo Martinez
Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help translate the knowledge of epigenetics to public health practice, the present study aims to explore the parallelism of methylation levels between white blood cells and buccal samples in relation to obesity and associated disorders...
March 28, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28337718/sex-dependent-effects-of-neonatal-maternal-deprivation-on-endocannabinoid-levels-in-the-adipose-tissue-influence-of-diet
#20
Virginia Mela, Fabiana Piscitelli, Alvaro Llorente Berzal, Julie Chowen, Cristoforo Silvestri, Maria Paz Viveros, Vincenzo Di Marzo
Maternal deprivation (MD) during neonatal life has diverse long-term effects, including modification of metabolism. We have previously reported that MD modifies the metabolic response to high-fat diet (HFD) intake, with this response being different between males and females, while previous studies indicate that in mice with HFD-induced obesity, endocannabinoid (EC) levels are markedly altered in various brown and white adipose tissue depots. Here, we analyzed the effects of MD (24 h at postnatal day 9), alone or in combination with a HFD from weaning until the end of the experiment in Wistar rats of both sexes...
March 23, 2017: Journal of Physiology and Biochemistry
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