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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/29447485/should-women-be-screened-for-osteoporosis-at-midlife
#1
T J de Villiers
Osteoporosis and associated fractures are common in women after midlife and will increase as the population ages. Osteoporosis-related fractures cause a significant increase in morbidity and mortality. Osteoporosis decreases the quality of life and productivity of many older women, with an increasing burden on health-care resources. Future risk of fracture can be managed by evidence-based interventions. It is thus appropriate to estimate the future risk of fracture in all women at the age of 50 years or at menopause, whichever occurs first...
February 15, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29447010/role-of-breast-density-measurement-in-screening-for-breast-cancer
#2
K E McLean, J Stone
Mammographic breast density is an established risk factor for breast cancer and significantly reduces the sensitivity of mammography, yet its use within breast cancer screening programs in Australia is limited. We provide a contemporary snapshot of the role of breast density measurement in screening for breast cancer and review the recent evidence for an increasing role of breast density measurement as: a predictor of breast cancer risk, a predictor of 'masking', and a biomarker to monitor effectiveness of intervention strategies for primary prevention or improved breast cancer outcomes...
February 15, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29436235/long-term-effects-of-vaginal-erbium-laser-in-the-treatment-of-genitourinary-syndrome-of-menopause
#3
M Gambacciani, M Levancini, E Russo, L Vacca, T Simoncini, M Cervigni
OBJECTIVES: To evaluate the long-term efficacy of a second generation of vaginal laser treatment, the vaginal erbium laser, as a non-ablative photothermal therapy for the management of genitourinary syndrome of menopause. METHODS: The study was performed using an erbium laser crystal yttrium-aluminum-garnet (XS Fotona Smooth™, Fotona, Ljubljana, Slovenia) with a wavelength of 2940 nm. Postmenopausal women (n = 205) were treated with three laser applications at 30-day intervals...
February 13, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29424257/romosozumab-treatment-in-postmenopausal-women-with-osteoporosis-a-meta-analysis-of-randomized-controlled-trials
#4
Y Liu, Y Cao, S Zhang, W Zhang, B Zhang, Q Tang, Z Li, J Wu
AIM: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of romosozumab in the treatment of postmenopausal osteoporosis. METHOD: A comprehensive literature review was performed of PubMed, EMBASE, Cochrane Controlled Trials Registry, and Web of Science for RCTs. Outcome measures were changes in lumbar spine, total hip and femoral neck bone mineral density (BMD), incidence of fractures and adverse events...
February 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29419315/decision-making-about-mammographic-screening-pursuing-informed-choice
#5
J Hersch, J Jansen, K McCaffery
For decades, persuasive techniques have been used to communicate to women about breast cancer screening with the aim of maximizing screening uptake. However, more recently this has shifted to an approach which recognizes that it is important for women to be aware of harms, such as overdiagnosis, as well as benefits of breast screening. There is a lack of consensus in the literature around whether benefits clearly outweigh harms for population-based breast cancer screening. In light of this, the gold standard for communication about breast cancer screening is now to try and support informed decision-making - that is, to help women understand both the advantages and disadvantages of screening, allowing them to make individual decisions about their screening participation that reflect their informed preferences...
February 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29419312/traditional-chinese-medicine-perspectives-on-and-treatment-of-menopausal-symptoms
#6
Qi Yu
No abstract text is available yet for this article.
February 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29411644/genitourinary-syndrome-of-menopause-prevalence-and-quality-of-life-in-spanish-postmenopausal-women-the-genisse-study
#7
E Moral, J L Delgado, F Carmona, B Caballero, C Guillán, P M González, J Suárez-Almarza, S Velasco-Ortega, C Nieto
OBJECTIVE: To determine the prevalence of genitourinary syndrome of menopause (GSM) and urogynecological conditions associated with menopause, and to evaluate the impact of GSM on quality of life in a cohort of Spanish postmenopausal women. METHODS: Multicenter, cross-sectional, and observational study involving 430 women. RESULTS: The prevalence of GSM was 70%. GSM was diagnosed in 60.2% of women with no known diagnosis of vulvovaginal atrophy or GSM...
February 7, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29397780/depressive-symptoms-affect-outcomes-of-pessary-use-in-postmenopausal-women-with-uterine-prolapse
#8
F-F Ai, L Zhu, M Mao, Y Zhang, J Kang
OBJECTIVE: This study aimed to investigate the impact of depressive symptoms on successful pessary treatment for postmenopausal women with symptomatic pelvic organ prolapse (POP). METHODS: We performed a prospective study involving postmenopausal women with POP who visited our clinic seeking pessary treatment. Demographic information and medical histories were collected. The participants completed the following questionnaires at baseline and after 3 months of successful pessary use: (1) the Pelvic Floor Impact Questionnaire-7 (PFIQ-7); (2) the Pelvic Floor Distress Inventory (PFDI-20); and (3) the Patient Health Questionnaire-9 (PHQ-9)...
February 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29390899/vasomotor-symptoms-natural-history-physiology-and-links-with-cardiovascular-health
#9
R C Thurston
Vasomotor symptoms (VMS), or hot flushes and night sweats, are the classic symptom of menopause. Recent years have brought key advances in the knowledge about VMS. VMS last longer than previously thought, on average 7-10 years for frequent or moderate to severe VMS. Although VMS have long been understood to be important to women's quality of life, research has also linked VMS to indicators of cardiovascular disease (CVD) risk, such as an adverse CVD risk factor profile, greater subclinical CVD and, in emerging work, CVD events...
February 2, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29390893/association-of-body-composition-with-menopausal-symptoms-in-peri-menopausal-women
#10
Y Zhou, Y Zheng, C Li, J Hu, Y Zhou, L Geng, M Tao
OBJECTIVE: To explore the correlation of body composition with the severity of menopausal symptoms, as well as each classic menopausal symptom. METHODS: A total of 758 (peri-)menopausal women were recruited (aged from 40 to 67 years) from the Menopause Clinic in the Shanghai Sixth People's Hospital. Different regions of fat mass, lean mass and fat-free mass were measured by bioelectrical impedance analysis, while menopausal symptoms were evaluated by valid modified Kupperman's index (KMI) in the Chinese version...
February 2, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29384406/the-impact-of-micronized-progesterone-on-breast-cancer-risk-a-systematic-review
#11
P Stute, L Wildt, J Neulen
Postmenopausal women with an intact uterus using estrogen therapy should receive a progestogen for endometrial protection. The debate on bioidentical hormones including micronized progesterone has increased in recent years. Based on a systematic literature review on the impact of menopausal hormone therapy (MHT) containing micronized progesterone on the mammary gland, an international expert panel's recommendations are as follows: (1) estrogens combined with oral (approved) or vaginal (off-label use) micronized progesterone do not increase breast cancer risk for up to 5 years of treatment duration; (2) there is limited evidence that estrogens combined with oral micronized progesterone applied for more than 5 years are associated with an increased breast cancer risk; and (3) counseling on combined MHT should cover breast cancer risk - regardless of the progestogen chosen...
January 31, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29381096/influence-of-menopausal-status-on-the-main-contributors-of-muscle-quality
#12
L P Carvalho, A Borghi-Silva, S Dupontgand, L Di Thommazo-Luporini, R G Mendes, M Aubertin-Leheudre
BACKGROUND: Muscle quality is a strong independent predictor of physical function. Body mass and fatness, muscle mass and cardiorespiratory fitness are known to influence muscle quality. OBJECTIVE: To identify the contributors of muscle quality in young and postmenopausal women and whether hormone replacement therapy (HT) could influence this relationship at the age of menopause. METHODS: Fifty-four postmenopausal women, 27 not on HT (PMW) and 27 on HT (PMW-HT), and 33 young women (YW) were evaluated for (1) body composition (body mass index, BMI), total fat mass (FM, %), appendicular lean mass (ALM, in kg and %), and appendicular skeletal mass index (ASMI = ALM/height2 in kg/m2); (2) absolute peak oxygen uptake (VO2peak, in ml/min) and relative peak oxygen uptake (VO2peakRel in ml/kg/min); and (3) absolute isometric knee extension strength (iKES in kg) and relative isometric knee extension strength (iKES/BMI and iKES/ALM)...
January 30, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29381086/treatment-of-vaginal-atrophy-with-estriol-and-lactobacilli-combination-a-clinical-review
#13
A O Mueck, X Ruan, V Prasauskas, P Grob, O Ortmann
In recent years, a vast quantity of clinical data has been accumulated on the pathophysiology of symptomatic vulvovaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM) in peri- and postmenopausal women and on the treatment options for these conditions. Guidelines from several societies have recently been updated in favor of VVA/GSM vaginal therapy with the lowest possible doses of estrogens. The combination of a vaginal ultra-low dose of 0.03 mg of estriol (E3) and lyophilized, viable Lactobacillus acidophilus KS400 (0...
January 30, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29378442/female-hormonal-factors-and-osteoarthritis-of-the-knee-hip-and-hand-a-narrative-review
#14
S M Hussain, F M Cicuttini, B Alyousef, Y Wang
Osteoarthritis is a leading cause of disability with no cure. The incidence of osteoarthritis is sexually dimorphic: women have a higher rate of osteoarthritis than men after the age of 50. Research has investigated the contribution of sex hormones, reproductive factors and hormone supplementation to osteoarthritis. It has been recognized that different joints are susceptible to different risk factors for osteoarthritis. We reviewed the evidence for the effect of endogenous sex hormones, reproductive factors and hormone supplementation on joint-specific osteoarthritis of the knee, hip and hand...
January 30, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29347848/role-of-topical-oxytocin-in-improving-vaginal-atrophy-in-postmenopausal-women-a-randomized-controlled-trial
#15
H A Torky, A Taha, H Marie, E El-Desouky, O Raslan, A A Moussa, A M Ahmad, A Abo-Louz, S Zaki, T Fares, A Eesa
OBJECTIVE AND DESIGN: Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women. PATIENTS AND METHODS: A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination were performed before and after treatment...
January 19, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29345506/effects-of-physical-and-depressive-symptoms-on-the-sexual-life-of-turkish-women-in-the-climacteric-period
#16
E Yanikkerem, A Göker, Ö Çakır, N Esmeray
OBJECTIVE: To assess the effects of physical and depressive symptoms on the sexual life of women in the climacteric period. METHODS: This study was conducted with 572 women at a university hospital. The Beck Depression Inventory (BDI), Menopause Rating Scale (MRS) and Female Sexual Function Index (FSFI) were used to evaluate depressive symptoms, intensity of menopausal symptoms and sexual function. RESULTS: Sexual dysfunction and depressive symptoms were determined in 86...
January 18, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29345497/experiences-of-menopause-self-management-strategies-for-menopausal-symptoms-and-perceptions-of-health-care-among-immigrant-women-a-systematic-review
#17
K A Stanzel, K Hammarberg, J Fisher
OBJECTIVE: To systematically review the published literature relating to experiences of menopause, self-management strategies for menopausal symptoms and health-care needs among immigrant women. METHODS: A systematic literature search of English-language publications was performed using Medline, Embase, PsychInfo, Cinahl and Scopus. Twenty-four papers reporting on 19 studies met our inclusion criteria and investigated immigrant women's experiences of menopause and/or their self-management strategies for menopausal symptoms and/or their perceptions of menopause-specific health care...
January 18, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29338480/the-role-of-screening-mammography-in-the-era-of-modern-breast-cancer-treatment
#18
A B Miller
The evidence is reviewed on the efficacy and effectiveness of mammography screening derived from randomized screening trials and from the surveillance of populations where mammography screening for breast cancer has been introduced. Nearly all the trials were performed in the era before modern adjuvant therapy for breast cancer was introduced, apart from the Canadian National Breast Screening Study and the UK Age trial. The former found no benefit from annual mammography screening for 5 years in women age 40-59 years, the latter, a non-significant benefit from screening women by annual mammography for 7 years from ages 39 to 41 years...
January 17, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29338440/selective-progesterone-receptor-modulators-current-applications-and-perspectives
#19
N Chabbert-Buffet, K Kolanska, E Daraï, P Bouchard
Selective progesterone receptor modulators (SPRMs) are steroid progesterone receptor ligands able to induce agonistic or antagonistic activities. Mifepristone, the class leader, was primarily used for pregnancy termination from the 1980s. Emergency contraception with extended activity was the second major development 30 years later, with mifepristone in some countries and ulipristal acetate world-wide. More recently, ulipristal acetate was released for the treatment of myoma-related uterine bleeding. In addition to a very rapid cessation of bleeding, SPRMs allow a decrease in myoma volume, as do gonadotropin releasing hormone analogs...
January 17, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29323578/effects-of-black-cohosh-and-estrogen-on-core-body-and-tail-skin-temperatures-in-ovariectomized-rats-by-telemetric-monitoring-with-dual-thermistor-probes
#20
Y Sun, L H Qin, X Chen, X Yan, L Mao, W Bai, J Kang
OBJECTIVES: To investigate the effects of black cohosh and estrogen on the temperature in ovariectomized rats, the core body temperature (CBT) and tail-skin temperature (TST) were simultaneously monitored and the relationship between these two temperatures was explored. METHODS: Twenty-four female Sprague-Dawley rats aged 8 weeks were randomly divided into four groups: sham-operated (SHAM), ovariectomized (OVX), OVX treated with estradiol valerate (OVX + E), and OVX treated with isopropanolic black cohosh extract (OVX + ICR)...
January 11, 2018: Climacteric: the Journal of the International Menopause Society
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