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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/28453310/vasomotor-symptoms-in-menopause-a-biomarker-of-cardiovascular-disease-risk-and-other-chronic-diseases
#1
N Biglia, A Cagnacci, M Gambacciani, S Lello, S Maffei, R E Nappi
Menopausal disorders may include shorter-term symptoms, such as hot flushes and night sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as cardiovascular disease (CVD), osteoporosis, and cognitive impairment. Initially, no clear link between the shorter-term symptoms and longer-term chronic conditions was evident and these disorders seemed to occur independently from each other. However, there is a growing body of evidence demonstrating that VMS may be a biomarker for chronic disease...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453308/genitourinary-syndrome-of-menopause-in-five-asian-countries-results-from-the-pan-asian-revive-survey
#2
Y Chua, K K Limpaphayom, B Cheng, C M Ho, K Sumapradja, C Altomare, K Huang
OBJECTIVES: The Pan-Asian REVIVE survey aimed to examine women's experiences with genitourinary syndrome of menopause (GSM) and their interactions with health-care professionals (HCPs). METHODS: Self-completed surveys were administered face-to-face to 5992 women (aged 45-75 years) in Indonesia, Malaysia, Singapore, Taiwan, and Thailand. RESULTS: Of 638 postmenopausal women with GSM symptoms, only 35% were aware of the GSM condition, most of whom first heard of GSM through their physician (32%)...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453307/-643c%C3%A2-%C3%A2-t-rankl-gene-polymorphism-is-associated-with-osteoporosis-in-tunisian-postmenopausal-women
#3
R Sassi, H Sahli, E Cheour, S Sellami, A Ben Ammar El Gaaied
OBJECTIVES: The dynamic nature of the skeleton is achieved by a remodeling process. Receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) stimulates bone resorption by activating RANK signaling. Therefore it is considered as a candidate gene regulating susceptibility to osteoporosis. In the current study, we have investigated the association between the RANKL gene -693G > C and -643 C > T polymorphisms and bone mineral density (BMD) in a population of postmenopausal Tunisian women...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453298/primary-ovarian-insufficiency-with-t-5-13-a-case-report-and-literature-review-on-disrupted-genes
#4
F Mohamadhashem, M Rafati, F Hoseininasab, S Rostami, R Tabatabaie, S Rezai, M Keramatipour, S R Ghaffari
OBJECTIVES: To report a woman with primary ovarian insufficiency (POI) with reciprocal translocation between chromosomes 5 and 13. METHODS: Chromosomal analysis (G-banding) of a 39-year-old woman with elevated gonadotropin levels and secondary amenorrhea and review of the literature with a special focus on disrupted genes at the reported breakpoints. RESULTS: A reciprocal translocation between the long arms of chromosomes 5 and 13 was identified in the patient (46,XX,t(5;13)(q13;q14))...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28440666/relationship-between-delivery-modes-and-genitourinary-syndrome-among-postmenopausal-women
#5
M Yaralizadeh, P Abedi, P Salehinejad
OBJECTIVES: Many postmenopausal women suffer from genitourinary syndrome of menopause (GSM) due to the lack of estrogen. This study aimed to evaluate the relationship between mode of delivery and GSM among postmenopausal women. METHODS: We performed a case-control study of women who had had either vaginal delivery or Cesarean section. Data were collected through a sociodemographic questionnaire and a check list for assessing signs and symptoms of GSM. Subjective symptoms of vaginal atrophy (dryness, dyspareunia, itching, burning and paleness), pH of the vagina and maturation index were assessed and recorded...
April 25, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28438051/similarity-of-female-central-hypogonadotropic-hypogonadism-and-postmenopause
#6
I Ilovayskaya, V Zektser, L Lazebnik
OBJECTIVES: Central (hypogonadotropic) hypogonadism in women could be a cause of persistent amenorrhea and hypoestrogenemia as observed in postmenopause. This study aimed to compare the clinical, hormonal and biochemical features in women with non-physiological (central hypogonadism) and physiological (postmenopause) hypoestrogenemia. METHODS: A total of 161 young women, median age 24.9 years (interquartile range (IQR) 21.2; 30.5) with central hypogonadism (with isolated hypogonadotropic hypogonadism, n = 76, and with hypopituitarism, n = 85), 53 healthy young women, median age 23...
April 24, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28399661/hormone-therapy-for-premature-ovarian-insufficiency-patients-with-malignant-hematologic-diseases
#7
X Yang, C Wang, X He, J Wei, Y Wang, X Li, L-P Xu
OBJECTIVES: The current usage of hormone therapy (HT) among perimenopausal women is low in China, especial in women with premature ovarian insufficiency (POI) with malignant hematologic diseases. This study investigated the efficacy and safety of HT in POI patients with malignant hematologic diseases who have received myeloablative chemotherapy and hemopoietic stem cell transplantation (HSCT). METHODS: Patients who had POI after myeloablative chemotherapy and HSCT for malignant hematologic diseases were enrolled...
April 11, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28398825/climacteric-symptoms-and-their-relation-to-feminine-self-concept
#8
A Quiroga, C Larroy, P González-Castro
OBJECTIVES: To investigate women's subjective experiences in the climacteric transition, especially the impact of self-concept, quality of life and depression on the severity of climacteric symptoms. METHOD: Non-experimental, cross-sectional study, purpose sampling. To analyze the results, we proposed a three-way interaction, in which the direct effect of depression on the severity of climacteric symptoms would be buffered by perceived sexual quality of life, and mediated by self-concept...
April 11, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28391726/determinants-of-percent-mammographic-density-in-women-with-premature-ovarian-insufficiency
#9
F R Torelli, M F Brancalion, D A Yela, C L Benetti-Pinto
OBJECTIVE: To evaluate the determinants of breast density in women with premature ovarian insufficiency (POI). METHODS: In a cross-sectional study of 163 women with POI undergoing mammography, percent mammographic density (PMD) was evaluated by digitizing the image. PMD was correlated with age, age at menarche, age at POI, time since POI, body mass index (BMI), gestational history and hormone therapy (HT) use (duration, dose, regimen). RESULTS: POI was diagnosed at a mean age of 32...
April 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28391713/impact-of-insomnia-on-pain-in-postmenopausal-women
#10
C Frange, M Fernanda Naufel, M Levy Andersen, E Beraldi Ribeiro, M J B Castelo Girão, S Tufik, H Hachul
BACKGROUND: Sleep disturbances and pain are assumed to be reciprocally linked. Insomnia and pain are central symptoms of the postmenopausal period and are closely related. Insomnia affects quality of life, increases pain sensitivity, the risk of pain-related disability, and other health problems. OBJECTIVE: To investigate whether insomnia influences aspects of pain (pain intensity and the effect of pain on daily function) in postmenopausal women, and to evaluate the objective sleep pattern of insomniacs with pain...
April 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28379719/a-simple-anthropometric-tool-for-the-assessment-of-pre-sarcopenia-in-postmenopausal-women
#11
M E Morosano, I M Menoyo, M F Tomat, A M Masoni, S M Pezzotto
OBJECTIVES: The purpose of this research was to explore the performance of anthropometric tools in the assessment of low muscle mass in a group of postmenopausal women. METHOD: Fifty consecutive ambulatory postmenopausal women were studied. A complete clinical examination and an anthropometric evaluation following a standardized procedure were performed. Three indicators were devised: upper limb adjusted perimeter (ULAP), lower limb adjusted perimeter (LLAP), and appendicular adjusted perimeter (AAP)...
April 5, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28379074/the-menopausal-hot-flush-a-review
#12
D W Sturdee, M S Hunter, P M Maki, P Gupta, J Sassarini, J C Stevenson, M A Lumsden
The hot flush is the most characteristic and often the most distressing symptom of the menopause. It is a unique feature and yet the mechanism and health implications are still not fully understood. This review summarizes some of the current thoughts on factors contributing to flushing, the physiological, vascular and neuroendocrine changes associated with flushing and the possible cardiovascular and other health implications for women experiencing hot flushes. Therapy is not discussed.
April 5, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28379046/knowledge-and-attitudes-of-health-professionals-regarding-menopausal-hormone-therapies
#13
L Yeganeh, J Boyle, H Teede, A Vincent
OBJECTIVE: To evaluate the knowledge and attitudes of Australian health professionals (HPs) including general practitioners (GPs), gynecologists and endocrinologists, to menopausal hormone therapy (MHT). METHODS: Participants were recruited from medical societies/colleges and a national GP conference. An online survey containing devised and previously published questions was used. Data analysis included frequencies, ANOVA, χ(2) and regression analysis. RESULTS: A total of 745/888 responses were analyzed...
April 5, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28351156/long-term-exercise-training-and-soy-isoflavones-to-improve-quality-of-life-and-climacteric-symptoms
#14
A Fontvieille, I J Dionne, E Riesco
OBJECTIVE: To verify the efficacy of phytoestrogen supplementation combined with aerobic and resistance training on the improvement of climacteric symptoms and health-related quality of life (HRQoL) in postmenopausal women. METHODS: From a pool of women who had participated in a 1-year intervention study and were randomly assigned to either exercise + phytoestrogen (EX + PHY) or exercise + placebo (EX + PL), a total of 31 healthy but overweight women (mean age 59...
March 29, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28333562/information-on-early-menopause-is-the-internet-the-place-to-search
#15
J Aleksova, M Kuczynska-Burggraf, S Ranasinha, A Vincent
OBJECTIVE: Early menopause (EM), menopause before 45 years, affects up to 10% of women. The internet was perceived by women with EM to be the best source of information regarding EM; however, the reality is unknown. The aim of this study was to assess the quality and content of easily accessible websites relating to EM. METHODS: The keyword 'early menopause' was used for a web search using Google. The first two pages of results, plus an additional five websites, were analyzed for website quality and content by two independent reviewers according to published methodology...
March 23, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28326899/prevalence-and-predictors-of-complementary-and-alternative-medicine-non-pharmacological-interventions-use-for-menopausal-symptoms-within-the-uk-collaborative-trial-of-ovarian-cancer-screening
#16
A Gentry-Maharaj, C Karpinskyj, C Glazer, M Burnell, K Bailey, S Apostolidou, A Ryan, A Lanceley, L Fraser, I Jacobs, M S Hunter, U Menon
OBJECTIVES: The negative publicity about menopausal hormone therapy (MHT) has led to increased use of complementary and alternative medicines (CAM) and non-pharmacological interventions (NPI) for menopausal symptom relief. We report on the prevalence and predictors of CAM/NPI among UK postmenopausal women. METHOD: Postmenopausal women aged 50-74 years were invited to participate in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). A total of 202 638 women were recruited and completed a baseline questionnaire...
March 22, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28301216/bioidentical-menopausal-hormone-therapy-registered-hormones-non-oral-estradiol%C3%A2-%C3%A2-%C3%A2-progesterone-are-optimal
#17
M L'Hermite
The many advantages of registered bioidentical sex hormones over registered, conventional, non-bioidentical menopausal hormone therapy (MHT) are considered. The transdermal route of estrogen administration avoids excess venous thromboembolic and ischemic stroke events. There is some indication that conjugated equine estrogens are more thrombogenic and most likely induce some hypertensive responses; estradiol might also be superior to conjugated equine estrogens (CEE) in terms of global cardiovascular health...
March 16, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28285543/feelings-of-unattractiveness-in-peri-and-postmenopausal-women-are-associated-with-depressed-mood-poor-memory-and-unsatisfactory-sexual-relationships
#18
M Terauchi, A Hirose, M Akiyoshi, K Kato, N Miyasaka
OBJECTIVES: This study aimed to investigate the prevalence of, and risk factors associated with, the feeling of unattractiveness in peri- and postmenopausal women. METHODS: The records of 351 women aged 40-76 who enrolled in a health and nutrition education program at a menopause clinic were analyzed in a cross-sectional manner. Perceptions of unattractiveness were estimated according to responses for the item 'feeling less attractive than before' on the Menopausal Health-Related Quality of Life Questionnaire...
March 11, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28267367/systematic-indirect-comparison-of-ospemifene-versus-local-estrogens-for-vulvar-and-vaginal-atrophy
#19
N Bruyniks, N Biglia, S Palacios, A O Mueck
In the absence of a direct head-to-head study, we performed an indirect historical comparison of ospemifene 60 mg (Senshio(®)) vs. local vaginal estrogens in moderate or severe vulvar and vaginal atrophy (VVA). A literature search was carried out of clinical efficacy/safety trials of local vaginal estrogens in VVA approved in Europe. For efficacy comparison, studies had to be placebo-controlled and of 12 weeks' duration. For safety comparison, studies had to be ≥40 weeks' duration. Efficacy endpoints were the difference between active and placebo in change from baseline to week 12 for symptoms, vaginal pH, and maturation value (MV)...
March 7, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28267365/pharmacokinetics-of-the-fetal-estrogen-estetrol-in-a-multiple-rising-dose-study-in-postmenopausal-women
#20
H J T Coelingh Bennink, C Verhoeven, Y Zimmerman, M Visser, J-M Foidart, K Gemzell-Danielsson
OBJECTIVES: Estetrol (E4) is a natural fetal estrogen. In this open-label, multiple-rising-dose study, the pharmacokinetic effects of E4 in postmenopausal women were investigated as a secondary objective. METHODS: In total, 49 postmenopausal women were randomized to receive either 2 mg E4 or 2 mg estradiol valerate (E2V) for 28 days, or were (non-randomized) assigned to 10, 20, or 40 mg E4. The main outcome measures were: E4 plasma concentrations at trough, and on days 1 and 28; and E4 pharmacokinetic parameters AUC, Cmax and tmax on days 1 and 28...
March 7, 2017: Climacteric: the Journal of the International Menopause Society
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