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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/28691549/factors-associated-with-complementary-and-alternative-medicine-use-among-women-at-midlife
#1
C Costanian, R A G Christensen, H Edgell, C I Ardern, H Tamim
Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of such therapies...
July 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28682642/low-bone-mineral-density-is-associated-with-cancer-in-postmenopausal-women-the-methodological-issue
#2
F Moradpour, K Mansori
No abstract text is available yet for this article.
July 6, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28675703/changing-the-conversation-about-hormone-therapy
#3
JoAnn V Pinkerton
No abstract text is available yet for this article.
July 4, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28657769/monurelle-biogel-%C3%A2-vaginal-gel-in-the-treatment-of-vaginal-dryness-in-postmenopausal-women
#4
R E Nappi, A Cagnacci, A M Becorpi, C Nappi, A M Paoletti, M Busacca, S Martella, M Bellafronte, Z Tredici, C Di Carlo, V Corda, M Vignali, M Bagolan, M Sardina
OBJECTIVES: To evaluate efficacy, tolerability and safety of Monurelle Biogel(®) vaginal gel for treatment of vaginal dryness. METHODS: Multicenter, national, randomized, controlled vs. no-treatment, open-label study. Ninety-five postmenopausal women were randomized (48 to Monurelle Biogel(®) and 47 to no treatment). Primary endpoint was the change of Verbal Rating Scale (VRS) total score of vaginal atrophy (VA) symptoms after 8-week treatment. The main secondary endpoints were VRS single-item score, Vaginal Health Index (VHI) score, Maturation Index (MI), Female Sexual Function Index (FSFI), and Female Sexual Distress Scale-Revised (FSDS-R)...
June 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28622040/analysis-of-differential-genetic-expression-in-endometrial-polyps-of-postmenopausal-women
#5
J K Troncon, J Meola, F J Candido-Dos-Reis, O B Poli-Neto, A A Nogueira, J C Rosa-E-Silva
OBJECTIVES: To evaluate the expression of four genetic markers (PTEN, BCL2, MLH1, and CTNNB1), linked to endometrial carcinogenesis, in endometrial polyps of patients with and without postmenopausal bleeding in order to determine whether symptomatic endometrial polyps have a genetic phenotype similar to that of endometrial cancer. METHODS: Samples were obtained hysteroscopically from endometrial polyps of postmenopausal patients, and the expression of genetic markers involved in the pathogenesis of endometrial cancer (PTEN, BCL2, MLH1, and CTNNB1) was analyzed...
June 16, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28613955/sleep-duration-and-midlife-women-s-health
#6
A Pines
Sleep is mandatory for life and therefore any sleep deprivation or disruption might carry ill-health outcomes. The optimal night's sleep duration seems to be around 7 h, as too little sleep and too much sleep have been found to be associated with a variety of changes in well-being, physical and psychological parameters. This mini-review enlightens the potential health consequences of sleep disturbance relevant to menopause and midlife women's health. These include cardiovascular and metabolic derangements, cognitive impairment, osteoporosis, and cancer-related perspectives...
June 14, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28580794/association-of-objectively-measured-physical-activity-and-physical-fitness-with-menopause-symptoms-the-flamenco-project
#7
V A Aparicio, M Borges-Cosic, P Ruiz-Cabello, I Coll-Risco, P Acosta-Manzano, Z Špacírová, A Soriano-Maldonado
OBJECTIVE: The primary aim was to analyze the association of moderate-to-vigorous physical activity (MVPA) with menopause symptomatology and its overall impact. A secondary/exploratory aim was to assess the association of different components of physical fitness with menopause symptomatology. METHODS: This cross-sectional study comprised 191 perimenopausal women from Southern Spain (age range 45-60 years, mean age 52.6 ± 4.5 years). The Blatt-Kupperman Menopausal Index was used to evaluate menopause symptomatology...
June 3, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28569124/low-bone-mineral-density-is-associated-with-breast-cancer-in-postmenopausal-women-a-case-control-study
#8
P Ferreira Poloni, H De Luca Vespoli, B de Sousa Almeida-Filho, F Bueloni-Dias, J Nahas-Neto, E Aguiar Petri Nahas
OBJECTIVE: To evaluate risk factors for low bone mineral density (BMD) in postmenopausal breast cancer survivors compared with postmenopausal women without breast cancer (controls). METHOD: In this study, 112 breast cancer survivors were compared to 224 women (controls). Inclusion criteria were amenorrhea ≥12 months, age 45-75 years, treated for breast cancer, and metastasis-free for at least 5 years. The control group consisted of women without breast cancer, matched by age and menopause status (in a proportion of 1: 2 as sample calculation)...
June 1, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28569074/the-platelet-to-lymphocyte-ratio-as-a-predictor-of-patient-outcomes-in-ovarian-cancer-a-meta-analysis
#9
X-M Ma, X Sun, G-W Yang, M-W Yu, G-L Zhang, J Yu, Y Zhang, X-M Wang
OBJECTIVES: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer. METHODS: We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis...
June 1, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28539066/water-versus-land-based-treatment-for-postural-control-in-postmenopausal-osteoporotic-women-a-randomized-controlled-trial
#10
M Chaves Aveiro, M Arias Avila, V Santos Pereira-Baldon, A Santa Barbara Ceccatto Oliveira, K Gramani-Say, J Oishi, P Driusso
OBJECTIVE: To compare the effects of water-based and land-based physical therapy on postural control of older women with osteoporosis. METHODS: Thirty-six postmenopausal women with osteoporosis were allocated into two groups: land-based or water-based. Volunteers received 12 weeks of a supervised land-based or water-based physical therapy treatment. The outcome measure was postural control of the body during quiet standing on upright stance (eyes opened and closed), tandem and one-limb stance on a force plate...
May 25, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28523945/prevention-of-postmenopausal-osteoporosis-in-chinese-women-a-5-year-double-blind-randomized-parallel-placebo-controlled-study
#11
S Y Ran, Q Yu, Y Chen, S Q Lin
OBJECTIVES: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT. DESIGN: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28523940/delay-in-estrogen-commencement-is-associated-with-lower-bone-mineral-density-in-turner-syndrome
#12
H H Nguyen, P Wong, B J Strauss, G Jones, P R Ebeling, F Milat, A Vincent
OBJECTIVE: Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures. We investigated the prevalence and risk factors for low bone density and fractures in a TS cohort. METHODS: We included 76 TS patients (median age 28.5 years) attending a tertiary hospital between 1998 and 2015 who underwent dual-energy X-ray absorptiometry. Spine and femoral neck (FN) areal bone mineral density (aBMD) were compared with those of a control group. To adjust for smaller bone size, bone mineral apparent density (BMAD) was calculated...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28503946/fractional-co2-laser-therapy-a-new-challenge-for-vulvovaginal-atrophy-in-postmenopausal-women
#13
G P Siliquini, V Tuninetti, V E Bounous, F Bert, N Biglia
OBJECTIVE: To evaluate the effects of CO2 laser in the treatment of vulvovaginal atrophy (VVA) in postmenopausal women. METHODS: VVA was assessed in 87 postmenopausal women (mean age 58.6 ± 6.9 years) before and after the treatment. The protocol consisted of three monthly treatments and included the treatment of vulva. Subjective measures included VAS (Visual Analog Scale) both for vaginal dryness and dyspareunia; DIVA (Day-by-day Impact of Vaginal Aging); a questionnaire on treatment satisfaction and one about the degree of pain during the procedure...
May 15, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28497704/what-is-the-right-dose-of-modern-medicine
#14
Robin J Bell
No abstract text is available yet for this article.
May 12, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28489425/tissue-specific-effects-of-estrogen-on-glycerol-channel-aquaporin-7-expression-in-an-ovariectomized-mouse-model-of-menopause
#15
B Jin, X Chen, L Xing, W Xu, X Fu, J Zhu, X Mou, Z Wang, J Shu
OBJECTIVE: Elevated fat mass and redistribution of body fat are commonly observed in postmenopausal women. Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset of obesity. We hypothesized that estrogen supplementation could counteract this fat accumulation and redistribution through tissue-specific modulation of AQP7. METHODS: We measured fat depot weight, adipocyte size, and the expression of AQP7 and glycerol kinase (GK) in visceral and subcutaneous fat tissues of ovariectomized mice supplemented with or without 17β-estradiol...
May 10, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28457146/are-women-with-polycystic-ovary-syndrome-at-increased-cardiovascular-disease-risk-later-in-life
#16
M N Gunning, B C J M Fauser
To date, the world's leading cause of death amongst women is cardiovascular disease. Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile in early life. Apart from dyslipidemia, obesity and onset of type 2 diabetes mellitus, androgens are thought to influence cardiovascular health. The question rises whether women with PCOS are truly at risk for cardiovascular disease in later life. In this review paper, we aim to reflect on this assumed relation based on studies in different stages of life in women with PCOS...
April 29, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453310/vasomotor-symptoms-in-menopause-a-biomarker-of-cardiovascular-disease-risk-and-other-chronic-diseases
#17
N Biglia, A Cagnacci, M Gambacciani, S Lello, S Maffei, R E Nappi
Menopausal disorders may include shorter-term symptoms, such as hot flushes and night sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as cardiovascular disease (CVD), osteoporosis, and cognitive impairment. Initially, no clear link between the shorter-term symptoms and longer-term chronic conditions was evident and these disorders seemed to occur independently from each other. However, there is a growing body of evidence demonstrating that VMS may be a biomarker for chronic disease...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453308/genitourinary-syndrome-of-menopause-in-five-asian-countries-results-from-the-pan-asian-revive-survey
#18
Y Chua, K K Limpaphayom, B Cheng, C M Ho, K Sumapradja, C Altomare, K Huang
OBJECTIVES: The Pan-Asian REVIVE survey aimed to examine women's experiences with genitourinary syndrome of menopause (GSM) and their interactions with health-care professionals (HCPs). METHODS: Self-completed surveys were administered face-to-face to 5992 women (aged 45-75 years) in Indonesia, Malaysia, Singapore, Taiwan, and Thailand. RESULTS: Of 638 postmenopausal women with GSM symptoms, only 35% were aware of the GSM condition, most of whom first heard of GSM through their physician (32%)...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453307/-643c%C3%A2-%C3%A2-t-rankl-gene-polymorphism-is-associated-with-osteoporosis-in-tunisian-postmenopausal-women
#19
R Sassi, H Sahli, E Cheour, S Sellami, A Ben Ammar El Gaaied
OBJECTIVES: The dynamic nature of the skeleton is achieved by a remodeling process. Receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) stimulates bone resorption by activating RANK signaling. Therefore it is considered as a candidate gene regulating susceptibility to osteoporosis. In the current study, we have investigated the association between the RANKL gene -693G > C and -643 C > T polymorphisms and bone mineral density (BMD) in a population of postmenopausal Tunisian women...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28453298/primary-ovarian-insufficiency-with-t-5-13-a-case-report-and-literature-review-on-disrupted-genes
#20
F Mohamadhashem, M Rafati, F Hoseininasab, S Rostami, R Tabatabaie, S Rezai, M Keramatipour, S R Ghaffari
OBJECTIVES: To report a woman with primary ovarian insufficiency (POI) with reciprocal translocation between chromosomes 5 and 13. METHODS: Chromosomal analysis (G-banding) of a 39-year-old woman with elevated gonadotropin levels and secondary amenorrhea and review of the literature with a special focus on disrupted genes at the reported breakpoints. RESULTS: A reciprocal translocation between the long arms of chromosomes 5 and 13 was identified in the patient (46,XX,t(5;13)(q13;q14))...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
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