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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/29992832/identification-of-the-first-homozygous-polg-mutation-causing-non-syndromic-ovarian-dysfunction
#1
B Chen, L Li, J Wang, Y Zhou, J Zhu, T Li, H Pan, B Liu, Y Cao, B Wang
OBJECTIVE: To investigate the genetic cause of non-syndromic ovarian dysfunction in a patient from a consanguineous family. METHODS: This study examined a patient with irregular menstrual cycles and abnormal oocytes. The patient had undergone irregular hormone replacement therapy over 3 years to adjust the menstrual cycle and improve ovarian function. Prior to ovarian stimulation in our hospital, 3 months of androgen and regular hormone therapy were used as an intervention method...
July 11, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29987939/sexual-well-being-after-menopause-an-international-menopause-society-white-paper
#2
J A Simon, S R Davis, S E Althof, P Chedraui, A H Clayton, S A Kingsberg, R E Nappi, S J Parish, W Wolfman
Sexual well-being frequently declines following the menopause transition and can be associated with significant personal and relationship distress. This distress is the hallmark of female sexual dysfunction (FSD). FSD is highly prevalent in postmenopausal women. The prevalence of sexual problems increases with age, but conversely this is associated with decreasing distress with advancing age. This pattern has been seen across multiple international populations with varied cultural norms. While the etiology of FSD is multifactorial, the physiological changes of sex hormone insufficiency and postmenopausal symptoms, such as dyspareunia, are primary factors contributing to FSD at midlife...
July 10, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29962257/progesterone-for-the-prevention-and-treatment-of-osteoporosis-in-women
#3
J C Prior
Estradiol (E2) is women's dominant 'bone hormone' since it is essential for development of adolescent peak bone mineral density (BMD) and physiological levels prevent the rapid (3-week) bone resorption that causes most adult BMD loss. However, deceasing E2 levels trigger bone resorption/loss. Progesterone (P4) is E2's physiological partner, collaborating with E2 in every cell/tissue; its bone 'job' is to increase P4-receptor-mediated, slow (3-4 months) osteoblastic new bone formation. When menstrual cycles are normal length and normally ovulatory, E2 and P4 are balanced and BMD is stable...
July 2, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29962247/progesterone-for-treatment-of-symptomatic-menopausal-women
#4
J C Prior
This review's purpose is to highlight evidence that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely safe in menopausal women (who are more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCT) supplemented with basic science, population and observational data as needed. The barrier to use of progesterone is lack of awareness that safety concerns with estrogen-including 'menopausal hormone therapy' (MHT) are not applicable to progesterone...
July 2, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29856658/health-related-quality-of-life-and-its-associated-factors-in-chinese-middle-aged-women
#5
Y Huang, N D Chatooah, T Qi, G Wang, L Ma, Q Ying, Y Lan, Y Song, C Li, K Chu, P Chen, W Xu, H Wan, Y Cai, J Zhou
OBJECTIVE: The aim of this study was to compare health-related quality of life (HRQOL) by menopausal stage and investigate its associated factors in middle-aged Chinese women. METHOD: This was a cross-sectional, community-based study involving 868 participants aged 40-60 years in Gongshu District, Hangzhou, Zhejiang, PR China. HRQOL was assessed by the Short-Form Health Survey (SF-36). The menopausal symptoms and sociodemographic characteristics were surveyed...
June 1, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29852797/progesterone-progestins-and-the-breast-in-menopause-treatment
#6
A Gompel, G Plu-Bureau
Breast cancer is the main risk associated with menopause hormone therapy (MHT). It is a hormone-dependent cancer. In postmenopausal women, about 80% of cases are estradiol receptor-positive. In cohort studies only estradiol receptor-positive breast cancers are promoted by MHT. Different levels of risk with estrogen-only treatment and combined treatment with estrogen + progestin are shown in randomized trials and observational studies. Several non-randomized studies show a lower risk with progesterone and retroprogesterone than with synthetic progestins...
June 1, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29852783/progesterone-and-human-cognition
#7
V W Henderson
Progesterone is a neurosteroid and a neuroactive steroid, produced primarily by the corpus luteum and the placenta. In some animal models, progesterone affects cognitive performance, and its potential role in human cognition is especially germane to women. This role can be investigated through associations between peripheral concentrations of progesterone in blood or saliva and neuropsychological test results, through differences in cognitive profiles between women using menopausal hormone therapy with and without a progestogen, and through clinical trials...
June 1, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#8
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
May 28, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29790373/non-clinical-studies-of-progesterone
#9
R Sitruk-Ware
Progesterone is a steroid hormone that is essential for the regulation of reproductive function. Progesterone has been approved for several indications including the treatment of anovulatory menstrual cycles, assisted reproductive technology, contraception during lactation and, when combined with estrogen, for the prevention of endometrial hyperplasia in postmenopausal hormonal therapy. In addition to its role in reproduction, progesterone regulates a number of biologically distinct processes in other tissues, particularly in the nervous system...
May 23, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741110/vaginal-health-insights-views-attitudes-viva-latam-results-from-a-survey-in-latin-america
#10
R E Nappi, N R de Melo, M Martino, C Celis-González, P Villaseca, S Röhrich, S Palacios
OBJECTIVE: To investigate awareness in Latin America, knowledge of postmenopausal vaginal atrophy was evaluated in a sample of women from this region. METHODS: A total of 2509 postmenopausal women aged 55-65 years, resident in Argentina, Brazil, Chile, Colombia and Mexico, completed a structured online questionnaire. RESULTS: Over half the surveyed population (57%) reported experiencing symptoms of vaginal atrophy. Only 6% of the overall cohort attributed symptoms of vaginal atrophy directly to the condition, and 71% did not consider the condition to be chronic, resulting in many women not accessing effective therapy...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741107/ovarian-aging-an-ongoing-prospective-community-based-cohort-study-in-middle-aged-chinese-women
#11
X Sun, M Luo, M Ma, R Tang, Y Wang, G Liu, S Lin, R Chen
PURPOSE: This study described the design and development of a cohort study established to investigate the ovarian aging process and its impact on women's health. METHODS: A community-based prospective cohort study of middle-aged Chinese women was initiated in 2005 and is ongoing. Sociodemographic characteristics, menstrual calendars, and medical histories were recorded at baseline and at annual follow-ups. Physical measures, blood sampling, bone status assessment, and body composition evaluation are likewise performed annually...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741102/endometrial-pathology-in-recurrent-postmenopausal-bleeding-observational-study-of-385-women
#12
A Ghoubara, S Sundar, A A A Ewies
OBJECTIVES: Women with recurrent postmenopausal bleeding (PMB) are considered as being at higher risk for endometrial hyperplasia and cancer, and guidelines suggest offering hysterectomy in unexplained cases with repeated negative investigations. This study aims to determine the prevalence of endometrial pathology in women referred with recurrent PMB to help inform clinical practice. METHODS: This was an observational study of prospectively collected data over a 5-year period, including 1902 women referred to the PMB clinic...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29734845/the-prevalence-and-determinants-of-genitourinary-syndrome-of-menopause-in-chinese-mid-life-women-a-single-center-study
#13
L Geng, Y Zheng, Y Zhou, C Li, M Tao
OBJECTIVE: This study aimed to explore the prevalence and determinants of genitourinary syndrome of menopause (GSM) in Chinese mid-life women. METHODS: A cross-sectional single-center study was performed among 40-65-year-old women who participated in physical examinations at Shanghai Jiao Tong University Affiliated Sixth People's Hospital from December 2015 to December 2016. The participating women were questioned about their genitourinary symptoms, and the relationships between these symptoms and the women's demographic characteristics were evaluated...
May 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29991304/progesterone
#14
James H Pickar
No abstract text is available yet for this article.
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29991303/menopause-a-new-beginning
#15
Susan R Davis
No abstract text is available yet for this article.
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29630427/evidence-on-the-use-of-progesterone-in-menopausal-hormone-therapy
#16
S Mirkin
A need exists for a regulatory agency-approved hormone therapy (HT) with naturally occurring hormones combining progesterone (P4) and estradiol (E2), since no single product contains both endogenous hormones. Many women choose HT with P4 and millions of women around the world are using unapproved, poorly regulated compounded HT. The use of natural P4 in HT results, for the most part, in favorable outcomes without deleterious effects, as shown in clinical studies of postmenopausal women. Importantly, P4 used in HT prevents endometrial hyperplasia from estrogens while helping relieve vasomotor symptoms and improving quality-of-life measures...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29583028/progesterone-progestins-and-the-endometrium-in-perimenopause-and-in-menopausal-hormone-therapy
#17
A Gompel
It is well established that unopposed estrogen for hormone therapy in postmenopausal women (MHT) induces a dose-related stimulation of the endometrium associated with an increased risk of hyperplasia and endometrial cancer. Progesterone acts physiologically to counteract the proliferative effects of estradiol during the menstrual cycle. In MHT, progestogens protect the endometrium against the proliferative effects of estrogens in women with a uterus. Recent data suggest that, whereas micronized progesterone is apparently safer for the breast, it could be less efficient than synthetic progestin on the endometrium...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29714089/history-of-a-brief-time-reflections-of-the-first-female-president
#18
Mary Ann Lumsden
No abstract text is available yet for this article.
June 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29714088/screening-for-women-at-midlife-we-need-to-remain-vigilant
#19
Robin J Bell
No abstract text is available yet for this article.
June 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29609509/bowel-cancer-screening-for-women-at-midlife
#20
I Olver
In Australia one in 15 women will be diagnosed with colorectal cancer in their lifetime because of the high incidences of lifestyle risk factors. The risk could be reduced by taking aspirin. Evidence-based Clinical Practice Guidelines for the prevention, early detection and management of colorectal cancer produced by Cancer Council Australia and approved by the National Health and Medical Research Council recommended that 'population screening in Australia, directed at those at average risk of colorectal cancer and without relevant symptoms, is immunochemical fecal occult blood testing every 2 years, starting at age 50 years and continuing to age 74 years...
June 2018: Climacteric: the Journal of the International Menopause Society
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