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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/29790373/non-clinical-studies-of-progesterone
#1
R Sitruk-Ware
Progesterone is a steroid hormone that is essential for the regulation of reproductive function. Progesterone has been approved for several indications including the treatment of anovulatory menstrual cycles, assisted reproductive technology, contraception during lactation and, when combined with estrogen, for the prevention of endometrial hyperplasia in postmenopausal hormonal therapy. In addition to its role in reproduction, progesterone regulates a number of biologically distinct processes in other tissues, particularly in the nervous system...
May 23, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741110/vaginal-health-insights-views-attitudes-viva-latam-results-from-a-survey-in-latin-america
#2
R E Nappi, N R de Melo, M Martino, C Celis-González, P Villaseca, S Röhrich, S Palacios
OBJECTIVE: To investigate awareness in Latin America, knowledge of postmenopausal vaginal atrophy was evaluated in a sample of women from this region. METHODS: A total of 2509 postmenopausal women aged 55-65 years, resident in Argentina, Brazil, Chile, Colombia and Mexico, completed a structured online questionnaire. RESULTS: Over half the surveyed population (57%) reported experiencing symptoms of vaginal atrophy. Only 6% of the overall cohort attributed symptoms of vaginal atrophy directly to the condition, and 71% did not consider the condition to be chronic, resulting in many women not accessing effective therapy...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741107/ovarian-aging-an-ongoing-prospective-community-based-cohort-study-in-middle-aged-chinese-women
#3
X Sun, M Luo, M Ma, R Tang, Y Wang, G Liu, S Lin, R Chen
PURPOSE: This study described the design and development of a cohort study established to investigate the ovarian aging process and its impact on women's health. METHODS: A community-based prospective cohort study of middle-aged Chinese women was initiated in 2005 and is ongoing. Sociodemographic characteristics, menstrual calendars, and medical histories were recorded at baseline and at annual follow-ups. Physical measures, blood sampling, bone status assessment, and body composition evaluation are likewise performed annually...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29741102/endometrial-pathology-in-recurrent-postmenopausal-bleeding-observational-study-of-385-women
#4
A Ghoubara, S Sundar, A A A Ewies
OBJECTIVES: Women with recurrent postmenopausal bleeding (PMB) are considered as being at higher risk for endometrial hyperplasia and cancer, and guidelines suggest offering hysterectomy in unexplained cases with repeated negative investigations. This study aims to determine the prevalence of endometrial pathology in women referred with recurrent PMB to help inform clinical practice. METHODS: This was an observational study of prospectively collected data over a 5-year period, including 1902 women referred to the PMB clinic...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29734845/the-prevalence-and-determinants-of-genitourinary-syndrome-of-menopause-in-chinese-mid-life-women-a-single-center-study
#5
M Tao, L Geng, Y Zheng, Y Zhou, C Li
OBJECTIVE: This study aimed to explore the prevalence and determinants of genitourinary syndrome of menopause (GSM) in Chinese mid-life women. METHODS: A cross-sectional single-center study was performed among 40-65-year-old women who participated in physical examinations at Shanghai Jiao Tong University Affiliated Sixth People's Hospital from December 2015 to December 2016. The participating women were questioned about their genitourinary symptoms, and the relationships between these symptoms and the women's demographic characteristics were evaluated...
May 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29635954/pelvic-floor-muscle-function-and-emg-in-nulliparous-women-of-different-ages-a-cross-sectional-study
#6
D A S Bocardi, V S Pereira-Baldon, C H J Ferreira, M A Avila, A C S Beleza, P Driusso
BACKGROUND: Although aging is considered a risk factor for pelvic floor muscle dysfunction (PFMD), the effect of aging on the function of the pelvic floor muscles (PFM) remains unclear. OBJECTIVE: To compare PFM function and activity in nulliparous women in different age groups. METHODS: This was a cross-sectional study in which 70 women with ages between 18 and 69 years were divided into five age groups for evaluation. Initially, medical histories were taken, and then the PFM function was assessed using digital palpation (Modified Oxford Scale), manometry and surface electromyography (sEMG)...
April 11, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29630427/evidence-on-the-use-of-progesterone-in-menopausal-hormone-therapy
#7
S Mirkin
A need exists for a regulatory agency-approved hormone therapy (HT) with naturally occurring hormones combining progesterone (P4) and estradiol (E2), since no single product contains both endogenous hormones. Many women choose HT with P4 and millions of women around the world are using unapproved, poorly regulated compounded HT. The use of natural P4 in HT results, for the most part, in favorable outcomes without deleterious effects, as shown in clinical studies of postmenopausal women. Importantly, P4 used in HT prevents endometrial hyperplasia from estrogens while helping relieve vasomotor symptoms and improving quality-of-life measures...
April 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29609509/bowel-cancer-screening-for-women-at-midlife
#8
I Olver
In Australia one in 15 women will be diagnosed with colorectal cancer in their lifetime because of the high incidences of lifestyle risk factors. The risk could be reduced by taking aspirin. Evidence-based Clinical Practice Guidelines for the prevention, early detection and management of colorectal cancer produced by Cancer Council Australia and approved by the National Health and Medical Research Council recommended that 'population screening in Australia, directed at those at average risk of colorectal cancer and without relevant symptoms, is immunochemical fecal occult blood testing every 2 years, starting at age 50 years and continuing to age 74 years...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29609503/postmenopausal-endometriosis-drawing-a-clearer-clinical-picture
#9
D A Tan, M J G Almaria
This review aims to draw a clearer clinical picture of postmenopausal endometriosis. Based on limited literature, postmenopausal endometriosis emerges as an infrequent entity but with a clinical picture significantly unlike that of premenopausal endometriosis. In contrast to the premenopausal disease, postmenopausal endometriosis occurs in a state of ovarian estrogen deficiency, appears to have a greater predisposition to malignant change, may have a greater tendency to spread to extragonadal organs and develop into constrictive and/or obstructive lesions, and is preferably treated surgically...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29609500/an-unusual-hazard-of-menopause-in-the-workplace-a-case-report
#10
B G A Stuckey, M S Stuckey
Untreated vasomotor symptoms of the menopause can have a major impact on women at work. Recent recommendations advocate modification of the working environment, including adequate air-conditioning, to help relieve these symptoms. However, this may cause discomfort for work colleagues. We report the case of a 40-year-old woman with cold urticaria. Cold urticaria is a serious, potentially life-threatening condition. Our patient's symptoms were exacerbated when her postmenopausal work colleagues turned the air-conditioner temperature down to relieve their vasomotor symptoms...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29583028/progesterone-progestins-and-the-endometrium-in-perimenopause-and-in-menopausal-hormone-therapy
#11
A Gompel
It is well established that unopposed estrogen for hormone therapy in postmenopausal women (MHT) induces a dose-related stimulation of the endometrium associated with an increased risk of hyperplasia and endometrial cancer. Progesterone acts physiologically to counteract the proliferative effects of estradiol during the menstrual cycle. In MHT, progestogens protect the endometrium against the proliferative effects of estrogens in women with a uterus. Recent data suggest that, whereas micronized progesterone is apparently safer for the breast, it could be less efficient than synthetic progestin on the endometrium...
March 27, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29583019/vaginal-progesterone-and-the-vaginal-first-pass-effect
#12
M P Warren
Vaginal progesterone is an effective alternative to systemic administration by oral or intramuscular use. The first-pass effect is reviewed, as are the most common uses for this route of delivery. This includes use in hormone replacement therapy, luteal support particularly in assisted reproduction, and avoidance of side-effects of oral progestins and progesterone. Vaginal progesterone represents a unique therapeutic solution to a number of clinical problems.
March 27, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29570359/progestogens-and-venous-thromboembolism-in-menopausal-women-an-updated-oral-versus-transdermal-estrogen-meta-analysis
#13
P-Y Scarabin
Postmenopausal hormone therapy (HT) is a modifiable risk factor for venous thromboembolism (VTE). While the route of estrogen administration is now well recognized as an important determinant of VTE risk, there is also increasing evidence that progestogens may modulate the estrogen-related VTE risk. This review updates previous meta-analyses of VTE risk in HT users, focusing on the route of estrogen administration, hormonal regimen and progestogen type. Among women using estrogen-only preparations, oral but not transdermal preparations increased VTE risk (relative risk (RR) 1...
March 23, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29565690/cervical-screening-in-hpv-vaccinated-populations
#14
K Canfell
Cervical screening with cytology has been the basis for substantial reductions in cervical cancer incidence and mortality in most high-income countries over the last few decades. More recently, there have been two key, parallel developments which have prompted a major re-consideration of cervical screening. The first is the emergence of evidence on the improved sensitivity of human papillomavirus (HPV) DNA testing compared to cytology, and the second is the large-scale deployment of prophylactic vaccination against HPV...
June 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29565684/progestogens-and-pregnancy-loss
#15
H J A Carp
Progestational agents are often prescribed to prevent pregnancy loss. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. Progestogens have therefore been used at all stages of pregnancy including luteal-phase support prior to pregnancy, threatened miscarriage, recurrent miscarriage, and to prevent preterm labor. In luteal support, a Cochrane review reported that progestogens were associated with a higher rate of live births or ongoing pregnancy in the progesterone group (odds ratio 1...
March 22, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29526116/menopausal-hormone-therapy-a-better-and-safer-future
#16
D A Davey
Major advances in menopause hormone therapy (MHT) hold promise in the future of better and safer care for women at and after the menopause. The principal advances are: (1) the critical window or 'window of opportunity' in the 10 years or so after the menopause, during which the benefits of MHT in healthy women exceed any risks; (2) use of transdermal instead of oral administration of estrogen to reduce the risk of venous thromboembolism; (c) investigation of the use of oral micronized progesterone (MP) and vaginal MP to prevent endometrial hyperplasia and carcinoma without any increased risk of breast cancer and venous thromboembolism in postmenopausal women receiving estrogens; vaginal MP prevents endometrial proliferation in the short term but the long-term effects in MHT remain to be established; (4) investigation into the use of intrauterine levonorgestrel-releasing devices (LNG-IUDs), which are an attractive form of MHT in perimenopausal women, providing contraception and reducing uterine bleeding, although the risk of breast cancer with LNG-IUDs requires clarification...
March 11, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29493295/surgical-challenges-in-the-treatment-of-perimenopausal-and-postmenopausal-endometriosis
#17
E S Ozyurek, T Yoldemir, U Kalkan
Endometriosis is classically defined as a chronic, recurrent and progressive disease. It is known to be estrogen-dependent, but can still be observed during the peri- and postmenopausal periods. Medical management of endometriosis is palliative symptomatic relief. Surgery when properly and timely performed for the right person may treat endometriosis. However, there is always a risk of possible major or minor surgical complications, as well as loss of some functions due to nerve damage. Management of endometriosis in the woman approaching the end of her reproductive life may require special attention both due to the potential for recurrence and transformation into various endometriosis-associated malignancies...
March 1, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29714089/history-of-a-brief-time-reflections-of-the-first-female-president
#18
Mary Ann Lumsden
No abstract text is available yet for this article.
June 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29714088/screening-for-women-at-midlife-we-need-to-remain-vigilant
#19
Robin J Bell
No abstract text is available yet for this article.
June 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29553288/the-european-vulvovaginal-epidemiological-survey-eves-prevalence-symptoms-and-impact-of-vulvovaginal-atrophy-of-menopause
#20
S Palacios, R E Nappi, N Bruyniks, M Particco, N Panay
OBJECTIVES: The primary objective of the European Vulvovaginal Epidemiological Survey (EVES) was to assess, at a country level, the prevalence of postmenopausal women with vulvovaginal atrophy (VVA) confirmed by gynecological clinical assessment among all postmenopausal women attending menopause centers. METHOD: Women aged 45-75 years old with their last menstrual period more than 12 months before and who attended menopause or gynecology centers were included...
June 2018: Climacteric: the Journal of the International Menopause Society
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