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Climacteric: the Journal of the International Menopause Society

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https://www.readbyqxmd.com/read/30183402/risk-factors-of-long-term-mortality-in-middle-aged-women-a-27-year-follow-up-cohort
#1
J E Blümel, S Aedo, E Arteaga, M S Vallejo
OBJECTIVE: This study aimed to evaluate the impact of different risk factors on long-term mortality in middle-aged women. METHODS: Women who received preventive health care control between 1990 and 1993 were recruited. Anamnesis and physical examination were recorded. Blood samples for the measurement of glycemia and lipids were taken. Data are reported as of December 2017. RESULTS: We studied 1197 women aged between 40 and 60 years. We observed 183 deaths (survival 84...
September 5, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30156935/microsatellite-variation-of-esr1-esr2-and-ar-in-serbian-women-with-primary-ovarian-insufficiency
#2
J Li, R Dalgleish, S Vujovic, S Dragojevic-Dikic, M Ivanisevic, M Ivovic, M Tancic, J Thompson, F Al-Azzawi
OBJECTIVE: This study aimed to investigate the potential role of microsatellite polymorphisms of the estrogen receptor alpha gene (ESR1) TA repeat, estrogen receptor beta gene (ESR2) CA repeat, and androgen receptor gene (AR) CAG and GGN repeats among Serbian women with primary ovarian insufficiency (POI). These microsatellites have been reported to be associated with POI in different racial/ethnic populations. METHODS: A cohort of 196 POI cases matched with 544 fertile controls was recruited by the Institute for Endocrinology, Diabetes and Metabolic Disorders of Serbia between 2007 and 2010...
August 29, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30156931/effect-of-phytoestrogens-on-sexual-function-in-menopausal-women-a-systematic-review-and-meta-analysis
#3
M Najaf Najafi, M Ghazanfarpour
OBJECTIVE: This systematic review and meta-analysis aimed to critically evaluate the effectiveness of phytoestrogens on sexual disorders and severity of dyspareunia. MATERIALS AND METHODS: Relevant studies were identified through a systematic search of major databases such as PubMed, Cochrane Library, ISI Web of Science, and Scopus up to 29 September 2017, without any time limit. Two independent reviewers screened all abstracts and full-text articles. The final version of Jadad scale was used for evaluating the quality of trials...
August 29, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30156926/effects-of-oral-contraceptives-on-ovulation-induction
#4
Manuel Neves-E-Castro
No abstract text is available yet for this article.
August 29, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30145921/bothersome-menopausal-symptoms-amongst-postmenopausal-iranian-women
#5
E Fooladi, R J Bell, M Masoumi, M Azizi, Z Atarod, S R Davis
OBJECTIVES: This study was undertaken to determine the impact of menopause on middle-eastern women. METHODS: This was a cross-sectional study of 1520 women, aged 40-64 years, living in Sari, Northern Iran, recruited by multistage cluster sampling between October 2016 and April 2017. All women completed the Menopause Quality of Life Questionnaire (MENQOL) and Beck Depression Inventory-II (BDI-II). RESULTS: Of all the women, 54.5% were perimenopausal or postmenopausal...
August 26, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30124335/-long-term-effects-of-vaginal-erbium-laser-in-the-treatment-of-genitourinary-syndrome-of-menopause-pelvic-organ-prolapse-classification-issues
#6
Y-Y Liu, K-L Lin, C-Y Long
No abstract text is available yet for this article.
August 20, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30124068/author-s-reply
#7
M Gambacciani
No abstract text is available yet for this article.
August 20, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30122075/association-between-nonalcoholic-fatty-liver-disease-and-bone-mineral-density-in-postmenopausal-women
#8
Dong-Yun Lee, Joo Kyung Park, Kyu Yeon Hur, Sung Hee Um
OBJECTIVE: Growing evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with reduced bone mineral density (BMD). This study examined the association between NAFLD and BMD in postmenopausal Korean women. METHODS: This retrospective cross-sectional study analyzed 3739 postmenopausal women aged 50-59 years who visited a health promotion center for a routine checkup from 2009 to 2014. Menopause was defined as absence of menstruation for ≥12 months and an elevated follicle-stimulating hormone serum level (>20 IU/L)...
August 20, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30106314/association-of-serum-ferritin-levels-with-non-alcoholic-fatty-liver-disease-in-postmenopausal-women
#9
H-B Kim, H-S Lee, Y-J Lee
OBJECTIVE: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. METHODS: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46.4 ng/ml; T2, 46.5-76.1 ng/ml; and T3, ≥76.2 ng/ml. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis...
August 14, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30095022/the-effect-of-vitamin-d2-supplementation-on-muscle-strength-in-early-postmenopausal-women-a-randomized-double-blind-placebo-controlled-trial
#10
C Suebthawinkul, K Panyakhamlerd, P Yotnuengnit, A Suwan, N Chaiyasit, N Taechakraichana
BACKGROUND: Low serum 25-hydroxyvitamin D [25(OH)D] has been shown to be associated with low muscle mass and loss of muscle strength, resulting in increased disability and frailty in older men and women. Vitamin D deficiency is common in postmenopausal women. The primary objective of the present study was to evaluate the effects of vitamin D supplementation on muscle strength in early postmenopausal women. The effects of vitamin D2 supplementation on muscle mass and muscle cross-sectional area (CSA) were secondarily investigated...
August 10, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30092652/care-of-the-adult-woman-with-turner-syndrome
#11
S Shah, H H Nguyen, A J Vincent
Turner syndrome (TS) is the most common chromosomal abnormality in females, affecting up to 1/2000 live female births. TS is associated with partial or complete loss of the second X-chromosome in phenotypic females and is associated with increased morbidity and mortality. There are many challenges in providing optimal care for the adult TS women. This review highlights uncertainties that remain in hormone replacement therapy, bone health and cardiovascular optimization and discusses current management recommendations based on the recently published international guidelines and the experience at the TS clinic at Monash Health...
August 10, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30033769/lack-of-research-reproducibility-the-rise-of-open-science-and-the-need-for-continuing-education-in-research-methods
#12
R Haring, R J Bell
In this opinion piece, we discuss the issue of lack of reproducibility in medical research and the different approaches that are being taken to address this problem. One general approach involves much greater transparency including the pre-publication of a study protocol, analysis plan and analysis code as well as the ultimate sharing of data, doing away with the concept of the 'single wrap-up publication'. The other change required is to support the training and mentorship of young researchers and ensure that they are not working in isolation...
July 22, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29992832/identification-of-the-first-homozygous-polg-mutation-causing-non-syndromic-ovarian-dysfunction
#13
B Chen, L Li, J Wang, Y Zhou, J Zhu, T Li, H Pan, B Liu, Y Cao, B Wang
OBJECTIVE: To investigate the genetic cause of non-syndromic ovarian dysfunction in a patient from a consanguineous family. METHODS: This study examined a patient with irregular menstrual cycles and abnormal oocytes. The patient had undergone irregular hormone replacement therapy over 3 years to adjust the menstrual cycle and improve ovarian function. Prior to ovarian stimulation in our hospital, 3 months of androgen and regular hormone therapy were used as an intervention method...
July 11, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29987939/sexual-well-being-after-menopause-an-international-menopause-society-white-paper
#14
J A Simon, S R Davis, S E Althof, P Chedraui, A H Clayton, S A Kingsberg, R E Nappi, S J Parish, W Wolfman
Sexual well-being frequently declines following the menopause transition and can be associated with significant personal and relationship distress. This distress is the hallmark of female sexual dysfunction (FSD). FSD is highly prevalent in postmenopausal women. The prevalence of sexual problems increases with age, but conversely this is associated with decreasing distress with advancing age. This pattern has been seen across multiple international populations with varied cultural norms. While the etiology of FSD is multifactorial, the physiological changes of sex hormone insufficiency and postmenopausal symptoms, such as dyspareunia, are primary factors contributing to FSD at midlife...
July 10, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29991304/progesterone
#15
James H Pickar
No abstract text is available yet for this article.
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29991303/menopause-a-new-beginning
#16
Susan R Davis
No abstract text is available yet for this article.
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29962257/progesterone-for-the-prevention-and-treatment-of-osteoporosis-in-women
#17
J C Prior
Estradiol (E2) is women's dominant 'bone hormone' since it is essential for development of adolescent peak bone mineral density (BMD) and physiological levels prevent the rapid (3-week) bone resorption that causes most adult BMD loss. However, deceasing E2 levels trigger bone resorption/loss. Progesterone (P4) is E2's physiological partner, collaborating with E2 in every cell/tissue; its bone 'job' is to increase P4-receptor-mediated, slow (3-4 months) osteoblastic new bone formation. When menstrual cycles are normal length and normally ovulatory, E2 and P4 are balanced and BMD is stable...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29962247/progesterone-for-treatment-of-symptomatic-menopausal-women
#18
J C Prior
This review's purpose is to highlight evidence that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely safe in menopausal women (who are more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCT) supplemented with basic science, population and observational data as needed. The barrier to use of progesterone is lack of awareness that safety concerns with estrogen-including 'menopausal hormone therapy' (MHT) are not applicable to progesterone...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#19
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
August 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29790373/non-clinical-studies-of-progesterone
#20
R Sitruk-Ware
Progesterone is a steroid hormone that is essential for the regulation of reproductive function. Progesterone has been approved for several indications including the treatment of anovulatory menstrual cycles, assisted reproductive technology, contraception during lactation and, when combined with estrogen, for the prevention of endometrial hyperplasia in postmenopausal hormonal therapy. In addition to its role in reproduction, progesterone regulates a number of biologically distinct processes in other tissues, particularly in the nervous system...
August 2018: Climacteric: the Journal of the International Menopause Society
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