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International Journal of Molecular Medicine

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https://www.readbyqxmd.com/read/30387830/bone-morphogenetic-protein-2-alleviated-intervertebral-disc-degeneration-through-mediating-the-degradation-of-ecm-and-apoptosis-of-nucleus-pulposus-cells-via-the-pi3k-akt-pathway
#1
Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua Lv
The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus serotype 2 (AAV)]; and IDD + AAV2‑BMP2 (106, 108 and 1010). IL‑1β was used to treat primary nucleus pulposus (NP) cells to mimic IDD in vitro. The effects of BMP2 in IDD were determined by magnetic resonance imaging (MRI), hematoxylin and eosin staining and Alcian Blue staining in vivo...
November 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387813/hyperforin-improves-post-stroke-social-isolation%C3%A2-induced-exaggeration-of-psd-and-psa-via-tgf-%C3%AE
#2
Yujing Zhang, Peiyun Yu, Hong Liu, Hua Yao, Shanglong Yao, Shi-Ying Yuan, Jian-Cheng Zhang
Stroke survivors often experience social isolation, which can lead to post‑stroke depression (PSD) and post‑stroke anxiety (PSA) that can compromise neurogenesis and impede functional recovery following the stroke. The present study aimed to investigate the effects and mechanisms of post‑stroke social isolation‑mediated PSD and PSA on hippocampal neurogenesis and cognitive function. The effects of the natural antidepressant hyperforin on post‑stroke social isolation‑mediated PSD and PSA were also investigated...
November 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387814/ligustrazine-inhibits-platelet-activation-via-suppression-of-the-akt-pathway
#3
Li Li, Hongwei Chen, Aling Shen, Qiongyu Li, Youqin Chen, Jianfeng Chu, Liya Liu, Jun Peng, Keji Chen
Aberrant activation of platelets has a critical role in thrombotic vascular events, including atherosclerosis, arterial thrombosis and myocardial infarction. The process of platelet activation is associated with multiple intracellular signaling pathways, including the phosphoinositide 3‑kinase/AKT serine/threonine kinase (Akt) pathway. The well‑known medicinal herb Rhizoma Ligusticum Wallichii (RLW) has long been used in China to clinically treat various cardiovascular disorders. As the most pharmacologically active component of RLW, ligustrazine has been demonstrated to possess a potent antiplatelet activity...
November 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387806/effect-of-tetramethylpyrazine-and-hyperlipidemia-on-hepcidin-homeostasis-in-mice
#4
Miao Zhang, Ming-Yue Sun, Chun-Yu Guo, Jing-Shang Wang, Feng-Qin Xu, Hui-Jun Yin
Iron homeostasis is strictly regulated in mammals, and disordered iron metabolism is recognized as a risk factor for various diseases, including cardiovascular disease. The hepcidin‑ferroportin axis is the key signaling mechanism that controls systemic iron homeostasis. Increased serum hepcidin is associated with multiple types of cancer and atherosclerosis (AS), and therapeutics that decrease hepcidin levels have been proposed to treat these diseases. However, the effects of abnormal circulating hepcidin on hyperlipidemia remain unexploited...
November 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387805/resveratrol-suppresses-colon-cancer-growth-by-targeting-the-akt-stat3-signaling-pathway
#5
Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Guo
Colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer‑related deaths. Although surgical techniques and treatment strategies for colon cancer have advanced over the past two decades, the prognosis has not improved considerably. Resveratrol, a natural stilbene compound, possesses antioxidant, cardioprotective and anticancer properties. However, the role of resveratrol in colon cancer has not been fully elucidated. The present study demonstrated that resveratrol inhibited cell proliferation and colony growth in DLD1 and HCT15 colon cancer cells, but did not affect normal colon epithelial cells...
November 1, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387810/essential-oil-from-korean-chamaecyparis-obtusa-leaf-ameliorates-respiratory-activity-in-sprague%C3%A2-dawley-rats-and-exhibits-protection-from-nf-%C3%AE%C2%BAb-induced-inflammation-in-wi38-fibroblast-cells
#6
Suchismita Raha, Seong Min Kim, Ho Jeong Lee, Sang Joon Lee, Jeong Doo Heo, Venu Venkatarame Gowda Saralamma, Sang Eun Ha, Eun Hee Kim, Sung Phil Mun, Gon Sup Kim
To date, Korean hinoki cypress (Chamaecyparis obtusa), has been widely used for household and commercial purposes. Although the medicinal efficacy of hinoki cypress essential oil has been observed, that of the essential oil‑derived terpenes, which exhibit a mechanism that acts against lung inflammation, remains to be fully elucidated. The present study investigated the anti‑inflammatory effect of hinoki cypress leaf extracted essential oil on lipopolysaccharide (LPS)‑stimulated WI38 fibroblast cells by inhibiting the nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) pathway, which exhibited lung tissue protection through the olfactory administration of essential oil in Sprague‑Dawley rats...
October 31, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387804/differential-expression-of-mtor-components-in-endometriosis-and-ovarian-cancer-effects-of-rapalogues-and-dual-kinase-inhibitors-on-mtorc1-and-mtorc2-stoichiometry
#7
Karly-Rai Rogers-Broadway, Juhi Kumar, Cristina Sisu, Gurleen Wander, Emily Mazey, Jeyarooban Jeyaneethi, George Pados, Dimitris Tsolakidis, Eleftherios Klonos, Thomas Grunt, Marcia Hall, Jayanta Chatterjee, Emmanouil Karteris
Endometriosis is a well‑known risk factor for ovarian cancer. The genetic changes that characterise endometriosis are poorly understood; however, the mechanistic target of rapamycin (mTOR) pathway is involved. In this study, we investigated the expression of key mTOR components in endometriosis and the effects of rapalogues using an endometrioid ovarian carcinoma cell line (MDAH 2774) as an in vitro model. Gene expression of mTOR, DEPTOR, Rictor and Raptor was assessed by qPCR in 24 endometriosis patients and in silico in ovarian cancer patients...
October 31, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387812/isorhamnetin-protects-against-bleomycin-induced-pulmonary-fibrosis-by-inhibiting-endoplasmic-reticulum-stress-and-epithelial-mesenchymal-transition
#8
Qing Zheng, Ming Tong, Baiqing Ou, Cuizhong Liu, Changping Hu, Yu Yang
The present study aimed to determine whether isorhamnetin (Isor), a natural antioxidant polyphenol, has antifibrotic effects in a murine model of bleomycin‑induced pulmonary fibrosis. A C57 mouse model of pulmonary fibrosis was established by intraperitoneal injection of a single dose of bleomycin (3.5 U/kg), and then Isor (10 and 30 mg/kg) was administered intragastrically. The level of fibrosis was assessed by hematoxylin and eosin and Sirius red staining. α‑smooth muscle actin and type I collagen levels in lung tissues were determined by western blotting and immunohistochemistry (IHC)...
October 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387824/epigenetic-mechanisms-and-implications-in-tendon-inflammation-review
#9
Finosh G Thankam, Chandra S Boosani, Matthew F Dilisio, Devendra K Agrawal
Cellular inflammation is not just an immediate response following pathogenic infections or resulting from damage due to injury, it is also associated with normal physiological functions, including wound healing and tissue repair. The existence of such a definitive role in normal physiology and in disease pathology indicates the presence of a regulatory mechanism that is tightly controlled in normal cells. A tight control over gene expression is associated with regulatory mechanisms in the cells, which can be either inducible or epigenetic...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387821/the-short-term-effect-of-histone-deacetylase-inhibitors-chidamide-and-valproic-acid-on-the-nf%C3%A2-%C3%AE%C2%BAb-pathway-in-multiple-myeloma-cells
#10
Zhaoyun Liu, Qian Jing, Yangyang Wang, Yanqi Li, Fu Mi, Chenhuan Xiang, Rong Fu
Research regarding histone deacetylase (HDAC) inhibitors (HDACis) has garnered interest for the treatment of multiple myeloma (MM). In addition, the high expression of nuclear factor (NF)‑κB in MM cells is considered an important factor in the occurrence and development of MM. The present study aimed to determine the short‑term effects of HDACis, chidamide and valproic acid (VPA), on MM cells, their effects on NF‑κB and the underlying mechanisms. The present study measured HDAC activity, and the proliferation and apoptosis of U266 and RPMI8226 MM cells following treatment with various concentrations of chidamide and VPA for 6 and 48 h...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387811/spicatoside-a-in-red-liriope-platyphylla-displays-a-laxative-effect-in-a-constipation-rat-model-via-regulating-machrs-and-er-stress-signaling
#11
Ji Eun Kim, Jun Go, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang
Red Liriope platyphylla extract (EtRLP) has been used as an oriental medicine for treatment of several chronic conditions, such as neurodegenerative disorders, diabetes, and obesity. To investigate the laxative activity of EtRLP, the levels of key constipation markers and their molecular regulators were examined following administration of EtRLP in constipation Sprague Dawley (SD) rats treated with loperamide (Lop). Compared with the Lop+Vehicle‑treated group, the excretion levels of urine and stool were significantly enhanced in the Lop+EtRLP‑treated group, even though feeding levels were kept constant...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387809/n-acetylcysteine-alleviates-h2o2-induced-damage-via-regulating-the-redox-status-of-intracellular-antioxidants-in-h9c2-cells
#12
Xiehong Liu, Li Wang, Jiaodi Cai, Ke Liu, Meidong Liu, Hao Wang, Huali Zhang
N‑acetylcysteine (NAC) is a thiol‑containing antioxidant that modulates the intracellular redox state. NAC can scavenge reactive oxygen species (ROS) and maintain reduced glutathione (GSH) levels, in order to protect cardiomyocytes from oxidative stress. The present study aimed to determine whether NAC protects cardiomyocytes from oxidative damage by regulating the redox status of intracellular antioxidant proteins. The results revealed that NAC pretreatment increased cell viability and inhibited the activation of caspase‑3, ‑8 and ‑9 during hydrogen peroxide (H2O2)‑induced oxidative stress in H9c2 cells...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387808/senp1-has-an-important-role-in-lung-development-and-influences-the-differentiation-of-alveolar-type-2-cells
#13
Xue-Qing Wan, Jia-Yu Cai, Yue Zhu, Qiu-Xia Wang, Hai-Tao Zhu, Hui-Min Ju, Hong-Yan Lu
Post‑translational modification via small ubiquitin‑like modifier (SUMO) is involved in the regulation of various important cellular processes. SUMO modification can be regulated at the level of conjugation, and can also be reversed by the SUMO‑specific proteases (SENPs). However, current studies of the regulation and function of SENP in lung development remain limited. In this study, the expression levels of SENP1 and SUMO1 were assessed during lung development in rats. SUMO1 modification occurred during lung development and changes in SENP1 expression were consistent with the changes in the presence of free SUMO1...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30387807/knockdown-of-long-non-coding-rna-metastasis-associated-lung-adenocarcinoma-transcript-1-inhibits-the-proliferation-and-migration-of-bladder-cancer-cells-by-modulating-the-microrna-34a-cyclin-d1-axis
#14
Ye Liu, Saiyue Gao, Qingyan Du, Qingsong Zhao
Long non‑coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been demonstrated to participate in the development and progression of some common cancer types, including bladder cancer (BC). However, the regulatory mechanism of MALAT1 underlying BC growth and metastasis remains to be fully elucidated. The present study revealed that MALAT1 was significantly upregulated in BC tissues and cell lines compared with the adjacent non‑tumour tissues and the normal urinary tract epithelial cell line SV‑HUC‑1, respectively...
October 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365097/downregulation-of-mir-145-5p-in-cancer-cells-and-their-derived-exosomes-may-contribute-to-the-development-of-ovarian-cancer-by-targeting-ct
#15
Wenzhao Hang, Yiwen Feng, Zhenyu Sang, Ye Yang, Yaping Zhu, Qian Huang, Xiaowei Xi
The present study aimed to identify shared microRNAs (miRNAs) in ovarian cancer (OC) cells and their exosomes using microarray data (accession number GSE103708) available from the Gene Expression Omnibus database, including exosomal samples from 13 OC cell lines and 3 normal ovarian surface epithelial cell lines, and their original cell samples. Differentially expressed miRNAs (DE‑miRNAs) were identified using the Linear Models for Microarray data method, and mRNA targets of DE‑miRNAs were predicted using the miRWalk2 database...
October 25, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365070/microrna-98-reduces-amyloid-%C3%AE-protein-production-and-improves-oxidative-stress-and-mitochondrial-dysfunction-through-the-notch-signaling-pathway-via-hey2-in-alzheimer-s-disease-mice
#16
Fang-Zhou Chen, Ying Zhao, Hui-Zhao Chen
Alzheimer's disease (AD) is a chronic neurodegenerative disease that often occurs at a slow pace yet deteriorates with time. MicroRNAs (miRs) have been demonstrated to offer novel therapeutic hope for disease treatment. The aim of the present study was to investigate the effect of miR‑98 on amyloid β (Aβ)‑protein production, oxidative stress and mitochondrial dysfunction through the Notch signaling pathway by targeting hairy and enhancer of split (Hes)‑related with YRPW motif protein 2 (HEY2) in mice with AD...
October 24, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365063/suppressive-effect-mediated-by-human-adipose-derived-stem-cells-on-t-cells-involves-the-activation-of-jnk
#17
Yinmin Wang, Xiuxia Wang, Xianyu Zhou, Zhu Zhu, Jun Yang, Fei Liu
Adipose‑derived stem cells (ADSCs) have an immunomodulatory role in vascularized composite tissue allo‑transplantation (VCA). However, the specific effects of ADSCs on lymphocytes remain to be fully elucidated. The present study examined the changes in T cells co‑cultured with ADSCs in terms of the proliferation by Cell Counting Kit‑8 assay, cell cycle profile and apoptosis by flow cytometry, inflammatory cytokine production by polymerase chain reaction and ELISA, in addition to the expression of survival proteins by western blotting...
October 24, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365048/deletion-of-foxl2-by-crispr-promotes-cell-cycle-g0-g1-restriction-in-kgn-cells
#18
Bin Tang, Yujie Zhang, Wei Zhang, Yuqing Zhu, Shaopeng Yuan
Forkhead box L2 (FOXL2), a member of the forkhead family of transcription factors, is important in eyelid and ovary differentiation. Although the function of FOXL2 in organogenesis has been investigated, the detailed mechanisms by which FOXL2 mediates cellular process remain to be fully elucidated. Few FOXL2‑knockout cell lines have been reported, which has limited molecular mechanism investigations. CRISPR is a novel gene editing technique that has been widely used in human genetic diseases. In the present study, FOXL2 was disrupted using clustered regularly interspaced short palindromic repeats (CRISPR), and screening of a stable knockout cell line was performed in human ovarian granulosa KGN cells...
October 24, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365044/muscat-bailey-a-grape-stalk-extract-ameliorates-high-fat-diet%C3%A2-induced-obesity-by-downregulating-ppar%C3%AE-and-c-epb%C3%AE-in-mice
#19
Bo-Mi Kim, Byoung Ok Cho, Seon Il Jang
Muscat Bailey A grape stalk is an organic waste produced in marked amounts during the vinification of grapes. Previous studies have indicated that grape stalk is rich in bioactive phenolic compounds, and exhibits antioxidant and UV‑protective activities. However, its effects on obesity and obesity‑associated disorders have not yet been investigated. The effects of grape stalk extract on improving metabolic features were examined using a high‑fat diet (HFD)‑induced obesity mouse model. Oral administration of 200 mg/kg/day grape stalk extract over 16 weeks markedly prevented HFD‑induced obesity, hepatic steatosis, diabetic symptoms and the risk of developing cardiovascular disease...
October 24, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365042/administration-of-plasmacytoid-dendritic-cell-stimulative-lactic-acid-bacteria-is-effective-against-dengue-virus-infection-in-mice
#20
Hiroaki Suzuki, Ryohei Tsuji, Miho Sugamata, Naoki Yamamoto, Norio Yamamoto, Osamu Kanauchi
Dengue virus (DENV), a mosquito‑borne flavivirus, causes an acute febrile illness that is a major public health problem in the tropics and subtropics globally. However, methods to prevent or treat DENV infection have not been well established. It was previously demonstrated that Lactococcus lactis strain plasma (LC‑plasma) has the ability to stimulate plasmacytoid dendritic cells (pDCs). As pDCs are key immune cells that control viral infection by producing large amounts of type I interferons (IFN), the present study evaluated the effect of LC‑plasma on DENV infection using a mouse infectious DENV strain...
October 24, 2018: International Journal of Molecular Medicine
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