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International Journal of Molecular Medicine

Chien-Hung Lin, Ming-Chang Chiang, Yann-Jang Chen
Nasopharyngeal carcinoma (NPC), a tumor arising from the epithelial cells of the nasopharynx, is endemic in Southeast Asia and Taiwan. The prognosis of NPC patients with local recurrence and metastasis is poor. Resistance to anoikis is a primary characteristic of tumor cells that metastasize. However, the mechanism through which NPC cells resist anoikis and are able to metastasize has not been fully elucidated. In the present study, the acquisition of anoikis resistance was analyzed in the TW01 and TW06 human NPC cell lines growing under anchorage-independent conditions...
September 25, 2017: International Journal of Molecular Medicine
Xianggui Yang, Dongming Wu, Hongfei Du, Fang Nie, Xueli Pang, Ying Xu
Transient receptor potential (TRP) cation channels are essential for normal cellular physiology, and their abnormal expression may lead to a number of disorders, including podocytopathy. Therefore, it is crucial to understand the mechanisms underlying the regulation of TRP channels. In the present study, microRNA (miR)-135a was found to be upregulated in patients with focal segmental glomerulosclerosis and mice treated with adriamycin (ADR). In cultured podocytes, transforming growth factor (TGF)-β and ADR were found to promote miR‑135a expression...
September 25, 2017: International Journal of Molecular Medicine
Tianyong Hu, Xiaoqin Fan, Li Ma, Jiangqi Liu, Yunli Chang, Pingchang Yang, Shuqi Qiu, Tao Chen, Litao Yang, Zhiqiang Liu
Skewed T helper 2 (Th2)‑cell polarization plays a critical role in the pathogenesis of allergic inflammations; however, the underlying mechanisms require further elucidation. The aim of the present study was to investigate the mechanisms through which the interaction between T‑cell immunoglobulin and mucin domain (TIM)4 and TIM1 regulates the expression of silent information regulator 1 (SIRT1) in Th2 cells, and the role of SIRT1 in Th2‑cell polarization during nasal allergic inflammation. The results demonstrated that TIM4 expression by splenic dendritic cells was increased in mice with allergic rhinitis, and the TIM4̸TIM1 interaction promoted CD4+ T cells to express SIRT1 during allergic inflammation via enhancing phosphoinositide 3‑kinase/Akt phosphorylation...
September 25, 2017: International Journal of Molecular Medicine
Kamila Domińska, Antoni Kowalski, Tomasz Ochędalski, Elżbieta Rębas
Angiotensin II (AngII), the main peptide of the renin‑angiotensin system (RAS), is involved in the proliferation of different types of cells, normal and pathological as well. The protein tyrosine kinases (PTKs) play an important role in the growth, differentiation and apoptosis of cells. AngII action depends on the hormonal milieu of the cell, and on sex steroid influence. Angiotensin 1‑7 (Ang1‑7), metabolite of AngII, shows opposite action to AngII in cells. The present study aimed to examine the influence of 17β‑estradiol and testosterone on AngII and Ang1‑7 action on PTK activity in androgen‑independent humane prostate cancer cell line DU145...
September 25, 2017: International Journal of Molecular Medicine
Wenwei Zheng, Pingdong Lin, Yuhuan Ma, Xiang Shao, Houhuang Chen, Da Chen, Xianxiang Liu, Xihai Li, Hongzhi Ye
Psoralen (PSO), the active ingredient of Fructus Psoraleae (FP) the dried ripe fruit of Psoralea corylifolia L., has been commonly used in traditional Chinese medicine (TCM) for the treatment of osteoarthritis (OA). We found that PSO activates cartilaginous cellular functions of rat chondrocytes in vitro. However, the effect of PSO on chondrocyte proliferation and the precise mechanisms involved remain to be elucidated. We investigated the effects of PSO on chondrocytes isolated from Sprague‑Dawley (SD) rats and evaluated involvement of the Wnt/β-catenin signaling pathway...
September 21, 2017: International Journal of Molecular Medicine
Ji-Eun Sung, Hyun-Ah Lee, Ji-Eun Kim, Woo-Bin Yun, Beum-Soo An, Seung-Yun Yang, Dong-Seob Kim, Chung-Yeoul Lee, Hee-Seob Lee, Chang-Joon Bae, Dae-Youn Hwang
Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction and airway hyper-responsiveness. The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. To accomplish this, alterations of the nitric oxide (NO) level, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, as well as variations in immune cell numbers, immunoglobulin E (IgE) concentration, histopathological structure and inflammatory cytokine levels were measured in lipopolysaccharide (LPS)-activated RAW264...
September 21, 2017: International Journal of Molecular Medicine
Haoran Shen, Zhou Liang, Saihua Zheng, Xuelian Li
The purpose of this study was to identify promising candidate genes and pathways in polycystic ovary syndrome (PCOS). Microarray dataset GSE345269 obtained from the Gene Expression Omnibus database includes 7 granulosa cell samples from PCOS patients, and 3 normal granulosa cell samples. Differentially expressed genes (DEGs) were screened between PCOS and normal samples. Pathway enrichment analysis was conducted for DEGs using ClueGO and CluePedia plugin of Cytoscape. A Reactome functional interaction (FI) network of the DEGs was built using ReactomeFIViz, and then network modules were extracted, followed by pathway enrichment analysis for the modules...
September 20, 2017: International Journal of Molecular Medicine
Jian Zhang, Xuekang Yang, Hongtao Wang, Bin Zhao, Xue Wu, Linlin Su, Songtao Xie, Yunchuan Wang, Jun Li, Jiaqi Liu, Mengdong Liu, Fu Han, Ting He, Wei Zhang, Ke Tao, Dahai Hu
Protein kinase Cζ (PKCζ) is a member of the atypical protein kinase C family. Its roles in macrophages or skin-resident keratinocytes have not been fully evaluated. In this study, we provide evidence that PKCζ mediates lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNFα) gene expression in the mouse macrophage cell line, RAW264.7. TNFα has been proven to be one of the main culprits of chronic wounds and impaired acute wounds, which are characterized by excessive inflammation, enhanced proteolysis and reduced matrix deposition...
September 20, 2017: International Journal of Molecular Medicine
Yongjian Li, Yunyang Chen, Haiyan Huang, Minmin Shi, Weiping Yang, Jie Kuang, Jiqi Yan
Caffeine has been identified to have beneficial effects against chronic liver diseases, particularly liver fibrosis. Many studies have reported that caffeine ameliorates liver fibrosis by directly inducing hepatic stellate cell (HSC) apoptosis; however, the molecular mechanisms involved in this process remain unclear. The presents study aimed to detect the underlying mechanisms by which caffeine mediates HSC apoptosis and eliminates activated HSCs. For this purpose, the LX-2 cell line was applied in this study and the cells were exposed to various concentrations of caffeine for the indicated times...
September 20, 2017: International Journal of Molecular Medicine
June Seok Heo, Seung Gwan Lee, Hyun Ok Kim
Mesenchymal stem cells (MSCs) differentiate into multiple lineages and are a promising source of cells for clinical use. Previously, we found that the gene distal‑less homeobox 5 (DLX5) is specifically expressed in MSCs with osteogenic potential. Understanding the mechanism of osteogenesis is necessary for successful bone regeneration using MSCs. The aim of this study was to examine the function of the DLX5 gene in MSCs during osteogenesis (bone development). We analyzed the possible association between DLX5 expression and osteogenesis-, chondrogenesis- and adipogenesis-related gene expression in different cells isolated from bone marrow and cord blood...
September 19, 2017: International Journal of Molecular Medicine
Hongjun Bian, Feifei Li, Wenwen Wang, Qi Zhao, Shanshan Gao, Jincai Ma, Xiao Li, Wanhua Ren, Chengyong Qin, Jianni Qi
Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C), leading to changes in cell morphology, differed significantly between the mouse macrophage cell line RAW264.7 and mouse primary peritoneal macrophages. Moreover, the expression of α- and β-tubulin was markedly decreased following LPS stimulation...
September 19, 2017: International Journal of Molecular Medicine
Seong-Lan Yu, Seungyun Han, Hong Rye Kim, Jong Woo Park, Dong Il Jin, Jaeku Kang
A reduction in pancreatic islet β-cells leads to the onset of diabetes. Hence, the identification of the mechanisms inducing β-cell proliferation is important for developing a treatment course against the disease. It has been well established that post-translational modifications (PTMs) of proteins affect their functionality. In addition, PTMs have been suggested to play important roles in organ regeneration. Therefore, in this study, we investigated PTMs associated with pancreatic regeneration using two-dimensional electrophoresis...
September 19, 2017: International Journal of Molecular Medicine
Pingping Liang, Lin Zhong, Lei Gong, Jiahui Wang, Yujie Zhu, Weifeng Liu, Jun Yang
Fibroblast growth factor 21 (FGF21), as an endocrine factor, is secreted into circulation by injured cardiomyocytes. Endoplasmic reticulum (ER) stress-induced apoptosis has been proposed as an important pathophysiological mechanism for cardiomyocyte injury. However, whether the enhanced expression of FGF21 in cardiomyocytes is linked to ER stress, and the effect and underlying mechanism of FGF21 on ER stress-induced cardiomyocyte apoptosis remain unclear. In the present study, it was demonstrated that mild ER stress resulted in upregulated expression levels of FGF21 and its main receptors, as a response to cell compensation, at the induction of ≤5 µM tunicamycin (TM)...
September 19, 2017: International Journal of Molecular Medicine
Hyun Ah Park, Jae-Won Lee, Ok-Kyoung Kwon, Gilhye Lee, Yourim Lim, Jung Hee Kim, Jin-Hyub Paik, Sangho Choi, Imam Paryanto, Prasetyawan Yuniato, Doo-Young Kim, Hyung Won Ryu, Sei-Ryang Oh, Seung Jin Lee, Kyung-Seop Ahn
Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation...
September 15, 2017: International Journal of Molecular Medicine
Dongru Chen, Liping Wu, Lu Liu, Qimei Gong, Jinxuan Zheng, Caixia Peng, Jianqing Deng
Hypoxia‑inducible factor‑1α (HIF‑1α) is essential for regulating the osteogenic differentiation of periodontal ligament cells (PDLCs). The regulatory mechanism of HIF‑1α transcription is still not clear. Recently, two long non‑coding RNAs, HIF1A antisense RNA 1 (HIF1A‑AS1) and HIF1A antisense RNA 2 (HIF1A‑AS2), were found to regulate HIF‑1α mRNA, but the regulatory mechanisms among HIF‑1α, HIF1A‑AS1 and HIF1A‑AS2 have not been well studied. We hypothesized that HIF1A‑AS1 and HIF1A‑AS2 play important roles in the osteogenic differentiation of PDLCs by regulating HIF‑1α...
September 15, 2017: International Journal of Molecular Medicine
Csaba Tóth, Farkas Sükösd, Erzsébet Valicsek, Esther Herpel, Peter Schirmacher, Marcus Renner, Christoph Mader, László Tiszlavicz, Jörg Kriegsmann
Liver metastasis in colorectal cancer is common and the primary treatment is chemotherapy. To date, there is no routinely used test in clinical practice to predict the effectiveness of conventional chemotherapy. Therefore, biomarkers with predictive value for conventional chemotherapy would be of considerable benefit in treatment planning. We analysed three proteins [excision repair cross-complementing 1 (ERCC1), ribonucleoside-diphosphate reductase 1 (RRM1) and class III β-tubulin (TUBB3)] in colorectal cancer liver metastasis...
September 14, 2017: International Journal of Molecular Medicine
Haiping Yang, Jianhua Fu, Li Yao, Ana Hou, Xindong Xue
Bronchopulmonary dysplasia (BPD) is a major challenge for premature infants; however, the underlying mechanisms remain unclear. We previously reported that epithelial-mesenchymal transition (EMT) in alveolar type II (AT2) epithelial cells influences the normal alveolar development process. In this study, we wished to examine whether Runx3 is an important factor for BPD by regulating EMT in AT2 cells. In vivo, animal models of BPD were established by placing newborn rats in hyperoxia tanks. Lung tissue and isolated AT2 cells were collected on different days following exposure to oxygen...
September 14, 2017: International Journal of Molecular Medicine
Yunshan Wang, Xiaoyan Liu, Hui Zheng, Qin Wang, Li An, Guangwei Wei
Following the publication of this article, a reader drew to our attention an anomaly associated with the data presented in Fig. 8. The reader found that the two images of the Control group treated with TGF-β1 in Fig. 8 have some overlap. After careful scrutiny, we found that we somehow misused a migation image for invasion (lower pannel) when constructing the final figure. This does not affect the interpretation of the experiments and the conclusions of the study. A corrected version of Fig. 8 is presented here...
September 14, 2017: International Journal of Molecular Medicine
Yi Chang, Wen-Hsien Hsu, Wen-Bin Yang, Thanasekaran Jayakumar, Tzu-Yin Lee, Joen-Rong Sheu, Wan-Jung Lu, Jiun-Yi Li
Antiplatelet agents have considerable benefits in the treatment of thromboembolic diseases; however, these agents still have substantial limitations due to their severe side-effects. In this study, the antiplatelet activity of three newly synthesized saccharide based benzimidazole derivatives, M3BIM, Malto-BIM and Melibio-BIM, in collagen and thrombin-stimulated human platelets in vitro was examined. Among the compounds tested, only compound M3BIM exerted concentration (20-60 µM)-dependent inhibitory effects against collagen (1 µg/ml) and thrombin (0...
September 13, 2017: International Journal of Molecular Medicine
Kaihua Wang, Zhenzhen Chen, Longjian Huang, Bing Meng, Xinmei Zhou, Xiaodong Wen, Ding Ren
Oxidative stress and mitochondrial dysfunction are considered to be major contributing factors in the development and progression of many neurodegenerative diseases. Naringenin (NAR) is an abundant flavanone in the Citrus genus and has been found to exert antioxidant, anticarcinogenic and antimutagenic effects. However, the potential underlying mechanism of its antioxidant effects remains unclear. In the present study, the authors investigated the antioxidant effect of NAR on neurons in vitro. Neurons isolated from the brains of Sprague-Dawley rats were randomly divided into a control group, model group, NAR-L group, NAR-M group and NAR-H group...
September 13, 2017: International Journal of Molecular Medicine
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