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Journal of Oral Science

Rantaro Kamimura, Mohammad Z Hossain, Shumpei Unno, Hiroshi Ando, Yuji Masuda, Kojiro Takahashi, Masanori Otake, Isao Saito, Junichi Kitagawa
Current therapeutics are not effective for orofacial neuropathic pain, and better options are needed. The present study used inferior orbital nerve (ION)-injured mice to investigate the effect of inhibiting monoacylglycerol lipase (MAGL), an enzyme that degrades the major endocannabinoid 2-arachydonoylgycerol (2-AG) in orofacial neuropathic pain. The head-withdrawal threshold to mechanical stimulation of the whisker pad was reduced on days 3, 5, and 7 after ION injury. Injection of JZL184, a selective inhibitor of MAGL, on day 7 after ION injury attenuated the reduction in head-withdrawal threshold at 2 h after administration...
March 2, 2018: Journal of Oral Science
Tetsuro Watase, Kohei Shimizu, Hiroki Komiya, Kinuyo Ohara, Koichi Iwata, Bunnai Ogiso
A study was conducted to evaluate the mechanisms underlying ectopic orofacial pain associated with tooth pulp inflammation in rats. We observed a significant decrease in the head withdrawal threshold (HWT) response to mechanical and heat stimuli applied to the ipsilateral facial skin upon application of complete Freund's adjuvant (CFA) to the upper first molar (M1TP) in comparison to application of vehicle. A large number of trigeminal ganglion (TG) neurons showed transient receptor potential vanilloid 1 (TRPV1) immunoreactivity (IR), and some of them were retrogradely labeled with fluorogold injected into the facial skin...
February 26, 2018: Journal of Oral Science
Ilda P Ribeiro, Joana M Rodrigues, Alexandra Mascarenhas, Nadezda Kosyakova, Francisco Caramelo, Thomas Liehr, Joana B Melo, Isabel M Carreira
Oral carcinoma develops from squamous epithelial cells by the acquisition of multiple (epi) genetic alterations that target different genes and molecular pathways. Herein, we performed a comprehensive genomic and epigenetic characterization of the HSC-3 cell line through karyotyping, multicolor fluorescence in situ hybridization, array comparative genomic hybridization, and methylation-specific multiplex ligation-dependent probe amplification. HSC-3 turned out to be a near-triploid cell line with a modal number of 61 chromosomes...
February 26, 2018: Journal of Oral Science
Niina Tsurumachi, Daisuke Akita, Koichiro Kano, Taro Matsumoto, Taku Toriumi, Tomohiko Kazama, Yoshinao Oki, Yoko Saito-Tamura, Morio Tonogi, Noriyoshi Shimizu, Masaki Honda
Dedifferentiated fat (DFAT) cells were isolated from mature adipocytes using the ceiling culture method. Recently, we successfully isolated DFAT cells from adipocytes with a relatively small size (<40 μm). DFAT cells have a higher osteogenic potential than that of medium adipocytes. Therefore, the objective of this study was to determine the optimal concentration of collagenase solution for isolating small adipocytes from human buccal fat pads (BFPs). Four concentrations of collagenase solution (0.01%, 0...
February 26, 2018: Journal of Oral Science
Mia-Michaela Beetge, Vladimir S Todorovic, Anna Oettlé, Jakobus Hoffman, Andre W van Zyl
The greater palatine foramen (GPF) is an important anatomical landmark and has substantial clinical relevance in dental surgery. Knowledge of its precise location and dimensions is required for proper planning of surgical procedures involving the posterior maxilla. We used microfocus computed tomography to determine the location and dimensions of the GPF, and any sex and race variations in those measurements, in 77 human skulls scanned at the South African Nuclear Energy Corporation. Specialized software was used for three-dimensional rendering, segmentation, and visualization of the reconstructed volume data...
February 26, 2018: Journal of Oral Science
Omid Dianat, Fatemeh Mashhadiabbas, Zohreh Ahangari, Sara Saedi, Saeed Reza Motamedian
Previous in vitro studies have suggested that simvastatin can be used as a direct pulp capping material due to its ability to induce odontoblastic differentiation and angiogenesis. The aim of this animal study was to evaluate the pulpal response to mineral trioxide aggregate (MTA) and four concentrations of simvastatin/MTA in combination. The study was conducted in two stages using four different simvastatin concentrations and MTA as a capping material for rat maxillary molars. The grades of inflammation and continuity of dentin formation were evaluated in hematoxylin and eosin (HE)-stained samples...
February 26, 2018: Journal of Oral Science
Cornelia Frese, Diana Wolff, Tanja Krüger, Hans J Staehle, Christopher J Lux, Ralf Erber
Placement of composite resin restorations in deep subgingival cavities can damage surrounding soft tissues. In addition, commonly used resin-based composites (RBCs) might interfere with wound healing and periodontal health. To clarify cellular interactions with RBCs, we used an MTT assay to investigate adhesion of primary human gingival fibroblasts and human osteoblasts (hFOB 1.19) on five RBC materials with and without surface modifications (alumina blasting with 50- or 110-μm Al 2 O 3 ). In addition, high-performance liquid chromatography (HPLC) was used to determine release of resin monomers from RBCs after 1 h, 1 day, and 7 days...
January 29, 2018: Journal of Oral Science
Akimasa Tsujimoto, Wayne W Barkmeier, Toshiki Takamizawa, Hidehiko Watanabe, William W Johnson, Mark A Latta, Masashi Miyazaki
This study evaluated the simulated localized wear of resin luting cements for universal adhesive systems using different curing modes. Five resin luting cements for universal adhesive systems were evaluated and subsequently subjected to wear challenge in a Leinfelder-Suzuki wear simulation device. Overall, 20 specimens from each resin luting cement were photo-cured for 40 s (dual-cure group), and 20 specimens of each material were not photo-cured (chemical-cure group). Simulated localized wear was generated using a stainless steel ball-bearing antagonist in water slurry of polymethylmethacrylate beads...
January 29, 2018: Journal of Oral Science
Omar Kujan, Michael N Pemberton, Martin Schwarz, Philip Sloan
The present study was conducted to assess the applicability of liquid-based cytology (LBC) using an innovative oral brush, Orcellex. Fifty healthy volunteers were recruited. From each subject, four samples were collected using "Orcellex" from apparently normal oral mucosal sites. A plastic spatula was also used to obtain an additional sample. Data on the tolerability and acceptability of the Orcellex were collected from the subjects, together with assessments of the adequacy of LBC slide preparations for cellularity, preparation quality, and the types of cells observed...
January 29, 2018: Journal of Oral Science
Hiroto Gunge, Yoichiro Ogino, Masafumi Kihara, Yoshihiro Tsukiyama, Kiyoshi Koyano
This retrospective study analyzed clinical outcomes of monolithic zirconia restorations (MZRs) and factors related to restoration success. Patient records were searched to identify those provided MZRs (Cercon ht) for premolars or molars between April 2012 and March 2016. All MZRs were placed according to a standardized protocol. Kaplan-Meier analysis was used to assess MZR performance and failure after recall appointments at 1 year or later. In total, 101 patients received 148 MZRs. Mean duration of follow-up was 25...
December 28, 2017: Journal of Oral Science
Adrian Salinas Fredricson, Farid Khodabandehlou, Carina Krüger Weiner, Aron Naimi-Akbar, Johanna Adami, Annika Rosén
Temporomandibular joint disorders (TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. This observational case-control study attempted to identify factors associated with TMJD development, particularly inflammation. The study participants were patients treated at Karolinska University Hospital, Stockholm, Sweden. The cases were patients who received a diagnosis of TMJD, chronic closed lock, or painful clicking and were treated surgically during the period from 2007 through 2011...
November 22, 2017: Journal of Oral Science
Ayako Teranaka, Kiyoshi Tomiyama, Katsura Ohashi, Kaori Miyake, Tota Shimizu, Nobushiro Hamada, Yoshiharu Mukai, Satoshi Hirayama, Tomotaro Nihei
We used a polymicrobial (PM) biofilm model to examine associations of bacterial adhesiveness with surface characteristics of various dental materials. Four types of dental materials (apatite pellet, zirconia, ceramic, and composite resin) with rough and mirror surfaces were used. Surface roughness, surface free energy, zeta potential, and colony-forming units (CFUs) of the biofilm formations were measured. Biofilms were cultured for 24 h under anaerobic conditions, plated onto blood agar medium, and anaerobically cultured for 4 days...
November 22, 2017: Journal of Oral Science
Masashi Kimura, Ken Takada, Kenichiro Ishibashi, Hiroyuki Ohto, Akio Shibata, Hiroki Yamada, Shusuke Nishiwaki, Yoshiyuki Naganawa, Masahiro Umemura
Reconstruction of oral defects using flaps following resection of oral cancer has become a standard approach for restoration of oral function. The purpose of this study was to investigate chronological changes in the volume of such flaps used for reconstruction and the factors affecting flap volume. We performed a retrospective analysis of 17 patients who had undergone oral cancer resection and reconstruction with flaps. Measurements were performed using data from computed tomography, and the flaps were selected semi-automatically using a computer-operated region-of-interest system...
November 22, 2017: Journal of Oral Science
Kazuyuki Handa, Natsuko Murakami, Toshiki Yamazaki, Hidekazu Takahashi, Noriyuki Wakabayashi
The purpose of this study was to investigate the wear volume and the principal strain of machinable dental composite and ceramics in simulated mastication. A ball-on-disk wear test was performed for 3,000 cycles in water, using nine ball/disk combinations of three commercial CAD/CAM materials: feldspathic, lithium disilicate glass ceramics, and a highly loaded composite material (n = 7 for each combination). The wear volume was optically measured using a digital scanner and analyzed for statistical differences based on the materials (α = 0...
November 17, 2017: Journal of Oral Science
Jie Nie, Fu-Cong Tian, Zu-Hua Wang, Adrian U Yap, Xiao-Yan Wang
This in vivo study aimed to evaluate the efficacy of in-office and home teeth bleaching in Asian patients. Moreover, the correlation between tooth color change and patient's outcome satisfaction was investigated. Overall, 40 Chinese patients were randomly divided into two groups and prescribed in-office (OB) or take-home bleaching (HB). The color of the maxillary central incisor and canine were recorded at baseline, immediately after first treatment, 1 week, and 3 months after treatment by using a spectrophotometer...
November 17, 2017: Journal of Oral Science
Maung Maung Kyaw Moe, Jung-Hong Ha, Myoung-Uk Jin, Young-Kyung Kim, Sung Kyo Kim
This study evaluated the anatomical profile of the mesial root canals of the Burmese mandibular first molar with Vertucci's type IV canal configuration (VT4) using microcomputed tomography analysis. Seventy-five mesial roots of extracted mandibular first molars were scanned and evaluated. Fourteen middle mesial canals (MMCs) were observed in the specimens; each specimen had an average of 1.63 lateral canals and 3.77 apical foramina. The lateral canals arising from the mesiobuccal canal, mesiolingual canal, MMC, and isthmus terminated at an average distance of 0...
November 17, 2017: Journal of Oral Science
Ayako Okada, Kaoru Sogabe, Hiroaki Takeuchi, Masaaki Okamoto, Yoshiaki Nomura, Nobuhiro Hanada
Quantitative analysis of periodontal bacteria is considered useful for clinical diagnosis, evaluation and assessment of the risk of periodontal disease. The purpose of this study was to compare the effectiveness of sampling of saliva, supragingival and subgingival plaque for evaluation of periodontal bacteria. From each of 12 subjects, i) subgingival plaque was collected from the deepest pocket using a sterile paper point, ii) stimulated whole saliva was collected after chewing gum, and iii) supragingival plaque was collected using a tooth brush...
November 17, 2017: Journal of Oral Science
Hidekazu Nagashima, Masamichi Shinoda, Kuniya Honda, Noriaki Kamio, Akira Hasuike, Naoyuki Sugano, Yoshinori Arai, Shuichi Sato, Koichi Iwata
Periodontitis caused by bacterial infection gradually progresses accompanied by periodontal tissue destruction. As a result, teeth lose their supporting structures, and this leads to tooth exfoliation. CXC-chemokine receptor 4 (CXCR4) is known to be expressed in lymphocytes, fibroblasts and osteoclasts in periodontal tissues, suggesting that periodontal CXCR4 signaling contributes to alveolar bone resorption in the milieu of periodontitis. However, the role of CXCR4 signaling in the pathogenesis of periodontitis has remained unknown...
October 31, 2017: Journal of Oral Science
Baleegh Alkadasi, Saleem Abdulrab, Soheir Gaafer, Butchibabu Kalakonda, Manal Hosny, Olfat Shaker, Mohamed Hosny
N-acetylcysteine (NAC) is an anti-oxidant drug that has been used as a mucolytic agent and a paracetamol antidote for many years. This study was designed to determine the efficacy of the adjunctive use of NAC for periodontal treatment. Thirty subjects with moderate-to-severe chronic periodontitis were randomized to surgery with NAC (600 mg; S-NAC), surgery only (S-nonNAC), and healthy control groups. Gingival crevicular fluid (GCF) samples were obtained from all patients and sRANKL levels were determined by enzyme-linked immunosorbent assay at baseline, and 1, 3, and 7 months post-surgery...
October 31, 2017: Journal of Oral Science
Moustafa A Elsyad, Salem M Eltowery, Ashraf A Gebreel
This study aimed to evaluate the peri-implant strain around mesially inclined implants used to retain mandibular overdentures with Locator resilient attachments. Four mandibular edentulous acrylic resin models received two implants in the canine areas with 0°, 5°, 10°, and 20° mesial inclinations. Overdentures were connected to the implants using Locator attachments. Pink nylon inserts (light retention) were used for all implant inclinations, and red inserts were used for 20° inclination (20°red). Four strain gages were bonded on the mesial (M), distal (D), buccal (B), and lingual (L) surfaces of each implant...
October 31, 2017: Journal of Oral Science
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