Dmitry V Chistyakov, Nadezhda V Azbukina, Alexander V Lopachev, Sergei V Goriainov, Alina A Astakhova, Elena V Ptitsyna, Anna S Klimenko, Vsevolod V Poleshuk, Rogneda B Kazanskaya, Tatiana N Fedorova, Marina G Sergeeva
Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipins on a system level, i.e., the analysis of oxylipin profiles. We analyzed oxylipin profiles in the blood plasma of 36 healthy volunteers (HC) and 73 patients with Parkinson's disease (PD), divided into early (L\M, 29 patients) or advanced (H, 44 patients) stages based on the Hoehn and Yahr scale...
October 20, 2023: Prostaglandins & Other Lipid Mediators