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Journal of Clinical Densitometry

Raffaella Tortora, Nicola Imperatore, Pietro Capone, Nicolò Gerbino, Matilde Rea, Giovanna Affinito, Nicola Caporaso, Antonio Rispo
The Fracture Risk Assessment (FRAX) tool has been developed to estimate patients' 10-yr probability of fracture, thus establishing which patients should undergo dual-energy X-ray Absorptiometry (DXA) scan. This study aimed to evaluate if the FRAX tool can replace or optimize the use of DXA scan in celiac disease (CD). We prospectively enrolled all CD patients aged over 40 yr diagnosed at our third-level unit. At time of CD diagnosis, all patients underwent FRAX score calculation for risk of major osteoporotic and hip fractures and DXA scan (used as gold standard) to assess the accuracy of the FRAX score...
June 15, 2017: Journal of Clinical Densitometry
Joy N Tsai, Linda A Jiang, Hang Lee, Didier Hans, Benjamin Z Leder
In postmenopausal women, 2 yr of combined teriparatide and denosumab increases bone mineral density more than either drug alone, and switching from either combination or teriparatide to denosumab for an additional 2 yr further increases bone mineral density. Conversely, switching from denosumab to teriparatide results in transient bone loss. The effects of these interventions on spine microarchitecture are unknown. In the DATA and DATA-Switch studies, 94 postmenopausal osteoporotic women were randomized to receive 24 mo of teriparatide (20 µg daily), denosumab (60 mg every 6 mo), or both...
June 14, 2017: Journal of Clinical Densitometry
Jordi Clotet, Yves Martelli, Silvana Di Gregorio, Luis Miguel Del Río Barquero, Ludovic Humbert
Structural parameters of the proximal femur evaluate the strength of the bone and its susceptibility to fracture. These parameters are computed from dual-energy X-ray absorptiometry (DXA) or from quantitative computed tomography (QCT). The 3-dimensional (3D)-DXA software solution provides 3D models of the proximal femur shape and bone density from anteroposterior DXA scans. In this paper, we present and evaluate a new approach to compute structural parameters using 3D-DXA software. A cohort of 60 study subjects (60...
June 14, 2017: Journal of Clinical Densitometry
Frans L Heyer, Joost J A de Jong, Rob J E M Smeets, Jacobus J Arts, Martijn Poeze, Piet P Geusens, Bert van Rietbergen, Joop P van den Bergh, Paul C Willems
No abstract text is available yet for this article.
June 13, 2017: Journal of Clinical Densitometry
Silvina R Mastaglia
Teriparatide (TPTD) (recombinant DNA origin human parathormone [1-34]) is approved for the treatment of glucocorticoid-induced osteoporosis (GIO). There are reports of factors that affect the response to TPTD in GIO treatment. This work describes the case of a 71-yr-old woman diagnosed with lupus nephropathy treated with 40 mg/d of meprednisone, and who suffered multiple vertebral fractures. Despite treatment with a single 5 mg dose of zoledronic acid, the patient continued to have vertebral fractures. Treatment with 20 µg/d of subcutaneous TPTD (PTH1-34, Forteo; Eli Lilly Co...
June 1, 2017: Journal of Clinical Densitometry
Shane Thurlow, Brian Oldroyd, Karen Hind
Dual-energy X-ray absorptiometry (DXA) body composition measurements are performed in both clinical and research settings for estimations of total and regional fat mass, lean tissue mass, and bone mineral content. Subject positioning influences precision and positioning instructions vary between manufacturers. The aim of the study was to determine the effect of hand position and scan mode on regional and total body bone and body composition parameters and determine protocol-specific body composition precision errors...
April 25, 2017: Journal of Clinical Densitometry
David A Stevenson, Heather Hanson, Austin Stevens, John Carey, David Viskochil, Xiaoming Sheng, Karen Wheeler, Hillarie Slater
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder associated with unilateral anterolateral bowing with subsequent fracture and nonunion. In infancy, physiologic bowing of the lower leg can be confused with pathologic tibial dysplasia in NF1. Little is known about the bone physiology of the tibiae prior to fracture or predictors of fracture. The aim of this study was to characterize bone quality of bowed tibiae prior to fracture in NF1 using quantitative ultrasound (QUS). Bone quality was assessed on both tibiae (the non-bowed and bowed tibiae) using QUS to measure speed of sound (SOS) at the mid-shaft in 23 individuals with NF1...
April 21, 2017: Journal of Clinical Densitometry
Joao Lindolfo C Borges, Isabella Santiago de M Miranda, Marta M S Sarquis, Victoria Borba, Sergio Setsuo Maeda, Marise Lazaretti-Castro, Neil Blinkey
The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric surgery. Moreover, there is no consensus on the optimal supplementation dose of vitamin D in postbariatric surgical patients. We present new data on the variability of 25(OH)D response to supplementation in postmenopausal obese women. It is important to recognize and treat vitamin D deficiency before bariatric surgery to avoid postoperative complications, such as metabolic bone disease with associated high fracture risk...
April 17, 2017: Journal of Clinical Densitometry
Rehne Lessmann Hansen, Bente Lomholt Langdahl, Peter Holmberg Jørgensen, Klaus Kjær Petersen, Kjeld Søballe, Maiken Stilling
Visual evaluation of bone changes around an osseointegration (OI) implant in femoral amputees examined on plain radiographs shows that periprosthetic bone resorption takes place during the first years after OI surgery, but the bone mineral density (BMD) change has not been previously quantified by dual-energy X-ray absorptiometry (DXA). Precision is vital when monitoring BMD changes around implants, and thus the aim of this study was to evaluate the precision and feasibility of a scan protocol for BMD measurements in proximity of OI implants...
April 4, 2017: Journal of Clinical Densitometry
Jenna C Gibbs, Zachary M Brown, Andy K O Wong, B Catharine Craven, Jonathan D Adachi, Lora M Giangregorio
The objective of this study was to compare the test-retest precision error for peripheral quantitative computed tomography (pQCT)-derived marrow density and marrow area segmentation at the tibia using 3 software packages. A secondary analysis of pQCT data in young adults (n = 18, mean ± standard deviation 25.4 ± 3.2 yr), older adults (n = 47, 71.8 ± 8.2 yr), and individuals with spinal cord injury (C1-T12 American Spinal Injury Association Impairment Scale, classes A-C; n = 19, 43...
March 27, 2017: Journal of Clinical Densitometry
Ronald C Hamdy
No abstract text is available yet for this article.
April 2017: Journal of Clinical Densitometry
John T Schousboe, Lisa Langsetmo, Ann V Schwartz, Brent C Taylor, Tien N Vo, Allyson M Kats, Elizabeth Barrett-Connor, Eric S Orwoll, Lynn M Marshall, Iva Miljkovic, Nancy E Lane, Kristine E Ensrud
Visceral adipose tissue (VAT) measured by computed tomography (CT) is related to insulin resistance, lipids, and serum inflammatory markers. Our objective was to compare the strength of the associations of VAT measured using dual-energy X-ray absorptiometry (DXA-VAT) and CT (CT-VAT) with insulin resistance, serum lipids, and serum markers of inflammation. For 1117 men aged 65 and older enrolled in the Osteoporotic Fractures in Men Study, the cross-sectional associations of DXA-VAT and CT-VAT with homeostasis model assessment of insulin resistance (homa2ir), C-reactive protein, and high-density lipoprotein (HDL) cholesterol were estimated with regression models and compared using a Hausman test...
April 2017: Journal of Clinical Densitometry
E Michael Lewiecki, John P Bilezikian, Susan V Bukata, Pauline Camacho, Bart L Clarke, Michael R McClung, Paul D Miller, John Shepherd
The Santa Fe Bone Symposium is an annual meeting of healthcare professionals and clinical researchers that details the clinical relevance of advances in knowledge of skeletal diseases. The 17th Santa Fe Bone Symposium was held in Santa Fe, New Mexico, USA, on August 5-6, 2016. The program included plenary lectures, oral presentations by endocrinology fellows, meet-the-professor sessions, and panel discussions, all aimed to provide ample opportunity for interactive discussions among all participants. Symposium topics included recent developments in the translation of basic bone science to patient care, new clinical practice guidelines for postmenopausal osteoporosis, management of patients with disorders of phosphate metabolism, new and emerging treatments for rare bone diseases, strategies to enhance fracture healing, and an update on Bone Health Extension for Community Healthcare Outcomes, using a teleconferencing platform to elevate the level of knowledge of healthcare professionals in underserved communities to deliver best practice care for skeletal diseases...
April 2017: Journal of Clinical Densitometry
Stephen Paul Tuck
No abstract text is available yet for this article.
April 2017: Journal of Clinical Densitometry
Charlles Heldan de Moura Castro, Vera Lúcia Szejnfeld
No abstract text is available yet for this article.
April 2017: Journal of Clinical Densitometry
Khurshid A Bhat, Manisha Kakaji, Ashish Awasthi, Karambir Kumar, Kshtij Mishra, Manoj Shukla, Sushil K Gupta
The osteoporosis self-assessment tool (OSTA) predicts the risk of osteoporosis in an individual. It is a simple calculation-based tool [wt (kg) - age (yr)/5] and can be used for measuring bone mineral density (BMD). However, OSTA is influenced by ethnicity. We studied the performance of OSTA index as a screening tool for osteoporosis in 257 community-dwelling North Indian men above 50 yr age. Each subject underwent a detailed clinical, dietary, anthropometric, and biochemical assessment and bone density measurement using dual-energy X-ray absorptiometry...
April 2017: Journal of Clinical Densitometry
Rajesh K Jain, Disha K Narang, Didier Hans, Tamara J Vokes
Trabecular bone score (TBS), a noninvasive textural analysis of the lumbar spine dual-energy X-ray absorptiometry (DXA) image, has been shown to predict fractures in Caucasian (CA) populations but has not been thoroughly studied in African-American (AA) populations. The aim of this study was to compare the TBS in AAs and CAs and to assess whether TBS can be used to refine fracture risk stratification in AA patients. Eight hundred twenty-five women (390 AAs, 435 CAs) referred for bone mineral density (BMD) as part of their clinical care had measurements of the TBS, the BMD of the lumbar spine, total hip, and femoral neck, and vertebral fracture assessment for detection of vertebral fractures...
April 2017: Journal of Clinical Densitometry
Xiao-Guang Cheng, Kai Li, Shan-Xing Ou, Guang-Yu Tang, Qian-Qian Wang, Chao Wang, Ling Wang, Wei Tian
This study compares spinal volumetric bone mineral density (vBMD) with spinal areal bone mineral density (aBMD) among young adults from 3 eastern provincial capital cities in Mainland China. A total of 416 young adults (age range: 20-40 yr) from 3 eastern provincial capital cities (Beijing, Shanghai, and Guangzhou) in Mainland China were recruited in this study. From each subject, the vBMD of the lumbar spine was measured by the Mindways quantitative computed tomography system. Moreover, the aBMD of the lumbar spine, measured by the dual-energy X-ray absorptiometry, was extracted from a previous multicenter large-scale study, and the 420 participants were matched by age, gender, height, weight, as well as geographic territory...
April 2017: Journal of Clinical Densitometry
César El Khoury, Hechmi Toumi, Eric Lespessailles, Antonio Pinti, Georges El Khoury, Ghassan Maalouf, Eddy Zakhem, Marie-Louise Ayoub, Eric Watelain, Rawad El Hage
No abstract text is available yet for this article.
April 2017: Journal of Clinical Densitometry
Gautier Zunquin, Abdel-Jalil Berro, Dominique Bouglé, Eddy Zakhem, Denis Theunynck, Ghazi Mawlawi, Marie-Louise Ayoub, Rawad El Hage
No abstract text is available yet for this article.
April 2017: Journal of Clinical Densitometry
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