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Journal of Clinical Densitometry

WeiWei Hu, Jinwei He, Wenzhen Fu, Chun Wang, Hue Yue, Jiemei Gu, Hao Zhang, Zhenlin Zhang
Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF subfamily and an important metabolic regulator that has multiple beneficial effects on glucose homeostasis and lipid metabolism. However, it was unclear whether FGF21 would induce bone defects in humans. This study evaluated the associations of FGF21 levels, bone mineral density (BMD), osteoporotic fracture, and bone turnover marks (BTMs) in postmenopausal women. A total of 1342 postmenopausal Chinese Han women (511 cases of fragility fracture in the case group and 831 cases in nonfragility fracture group) were enrolled...
August 22, 2018: Journal of Clinical Densitometry
B Thomas, N Binkley, P A Anderson, D Krueger
INTRODUCTION: Total knee arthroplasty (TKA) is increasingly being performed. Distal femur periprosthetic fracture is a potentially catastrophic complication following TKA and existing data document substantial distal femur bone mineral density (BMD) loss following TKA. However, distal femur BMD is virtually never measured clinically as no consensus approach exists. This pilot study's purpose was to define regional BMD variation throughout the femur, suggest standard dual-energy X-ray absorptiometry (DXA) regions of interest (ROIs) and evaluate BMD reproducibility at these ROIs...
August 13, 2018: Journal of Clinical Densitometry
M B Maldonado-Pérez, L Castro-Laria, A Caunedo-Álvarez, M J Montoya-García, M Giner-García, F Argüelles-Arias, M Romero-Gómez, M Á Vázquez-Gámez
BACKGROUND/OBJECTIVE: Osteoporosis and osteoporotic fracture risk are extraintestinal manifestations of the inflammatory bowel disease, whose etiopathogenic mechanisms have not been determined yet. Anti-tumor necrosis factor (TNF)-α are used in treatment of inflammatory bowel disease (IBD), but it is unknown if they play a role in osteoporotic fracture prevention. The objective of this study was to know if anti-TNF decreases fracture risk or modifies bone mineral density. To determine the possible risk factors associated with fractures, and assess the incidence of vertebral fractures in IBD patients...
August 13, 2018: Journal of Clinical Densitometry
Hui Tong, He-Xiang Zong, Sheng-Qian Xu, Xin-Rong Wang, Xun Gong, Jian-Hua Xu, Mengming Cheng
Osteoporosis Self-Assessment Tool for Asians (OSTA) is an indicator for assessing osteoporosis in postmenopausal women. The aim of this study was to investigate the value of OSTA index on predicting osteoporosis in elderly Chinese patients with established rheumatoid arthritis (RA). A total of 320 patients with RA and 158 normal individuals were recruited from January 2015 to October 2017. Bone mineral density (BMD) at the femur and lumbar spine was measured by dual-energy X-ray absorptiometry. RA group and control group were divided into low risk (values≥-1), medium risk (values between -4 and -1), and high risk (values ≤-4) group according to the value of OSTA index...
August 11, 2018: Journal of Clinical Densitometry
B C C Khoo, K Brown, J R Lewis, E Perilli, R L Prince
This paper explores the effects of aging on femoral neck (FN) anatomy in a study of women aged 20-90 years in relation to implications for FN fracture propensity in buckling. Five hundred and four participants were scanned by Quantitative Computed Tomography and analyzed using Quantitative Computed Tomography Pro BIT (Mindways). FN cross-section was split through geometric center into superior and inferior sectors. Bone mass, structural measurements, and bone mineral density were analyzed. Buckling ratio was calculated as ratio of buckling radius to cortical thickness...
August 9, 2018: Journal of Clinical Densitometry
Ho-Chuen Chang, Yu-Ching Lin, Shu-Hang Ng, Yun-Chung Cheung, Cheng-Hsu Wang, Fang-Ping Chen, Hui-Ping Chang, Chen-Ming Sung, Chih-Ming Fan, Kun-Yun Yeh, Jim S Wu
BACKGROUND: Precision error in dual-energy X-ray absorptiometry (DXA) is defined as difference in results due to instrumental and technical factors given no biologic change. The aim of this study is to compare precision error in DXA body composition scans in head and neck cancer patients before and 2 months after chemotherapy. METHODOLOGY: A total of 34 male head and neck cancer patients with normal body mass index (BMI) were prospectively enrolled and all patients received 2 consecutive DXA scans both before and after 2 months of chemotherapy for a total of 4 scans...
July 31, 2018: Journal of Clinical Densitometry
T Cervinka, L Giangregorio, H Sievanen, A M Cheung, B C Craven
In 2015, the International Society for Clinical Densitometry (ISCD) position statement regarding peripheral quantitative computed tomography (pQCT) did not recommend routine use of pQCT, in clinical settings until consistency in image acquisition and analysis protocols are reached, normative studies conducted, and treatment thresholds identified. To date, the lack of consensus-derived recommendations regarding pQCT implementation remains a barrier to implementation of pQCT technology. Thus, based on description of available evidence and literature synthesis, this review recommends the most appropriate pQCT acquisition and analysis protocols for clinical care and research purposes, and recommends specific measures for diagnosis of osteoporosis, assigning fracture risk, and monitoring osteoporosis treatment effectiveness, among patients with neurological impairment...
July 29, 2018: Journal of Clinical Densitometry
Lijia Cui, Yuping Xu, Qiming Xu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia
No abstract text is available yet for this article.
July 29, 2018: Journal of Clinical Densitometry
P Adamczyk, W Pluskiewicz
PURPOSE: The aim of the study was to assess the influence of regular karate training on the skeletal status evaluated by quantitative ultrasound (QUS) in females. METHODS: A group of 132 karate training girls and women at mean age 19.57 (standard deviation [SD] 7.64) yr (range 7.3-45.3 yr) and 322 age-, sex- and body size-matched controls were enrolled into the study. Mean training duration in the karate group was 7.52 (SD 5.05) yr and mean training frequency was 2...
July 21, 2018: Journal of Clinical Densitometry
Julian S Meyer, Tobias Freitag, Heiko Reichel, Ralf Bieger
INTRODUCTION: The objective of this prospective, randomized study was to evaluate differences in periprosthetic bone mineral density changes in the proximal femur after implantation of a cementless bone preserving stem (Fitmore) compared to a cementless straight stem (CLS Spotorno). METHODOLOGY: Periprosthetic bone mineral density was measured in 140 patients (aged 33-74 yr) before surgery, 7 d, 3, 12, and 60 mo postoperatively, using dual energy X-ray absorptiometry...
July 21, 2018: Journal of Clinical Densitometry
Je-Sang Lee, Keunyoung Kim, Yun Kyung Jeon, Jinmi Kim, Da Hwi Jung, Sang Hun Kim, Myung Jun Shin, Yong Beom Shin
INTRODUCTION: This study aimed to compare the performance of dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in evaluating bone mineral density (BMD) of patients with Duchenne muscular dystrophy and scoliosis. METHODOLOGY: Twenty-nine participants (mean age 19.72 ± 6.13 years) underwent whole spine radiography, DXA before and after traction, and QCT alone without traction. Scoliosis and vertebral rotation angles obtained before and after traction were compared, and BMD values from DXA were compared to those obtained via QCT...
July 20, 2018: Journal of Clinical Densitometry
Olusola F Sotunde, Sina Gallo, Catherine A Vanstone, Hope A Weiler
BACKGROUND: A leaner body phenotype in infancy plays an important role in the early life prevention of obesity. However, there is a dearth of reference data for body composition in infancy. This study aimed to create a normative reference dataset for lean (LM) and fat (FM) mass and accretion rates in healthy infants. METHODS: Healthy term-born infants (35 boys; 35 girls) were studied at ≤ 1, 3, 6, 9, and 12 mo of age for growth and compared to World Health Organization standards...
July 19, 2018: Journal of Clinical Densitometry
Geoffrey J Michalak, Richard Walker, Steven K Boyd
Osteoarthritis (OA) is a prevalent articular disease characterized by whole joint degradation, including articular cartilage and bone. Presently, no single imaging modality is well suited to concurrently capture these changes. Recent ex vivo animal studies have demonstrated the efficacy of utilizing contrast agents in conjunction with micro-CT as a means of evaluating cartilage and bone alterations concurrently, though no work as of yet has been performed in large animal models or humans. This study sought to develop and validate a novel joint imaging technique, contrast enhanced high resolution peripheral quantitative computed tomography (CEHR-pQCT), to concurrently assess bone microarchitecture and cartilage morphology in the whole human knee...
July 19, 2018: Journal of Clinical Densitometry
Chan Yoon, Moon Jong Chang, Chong Bum Chang, Jee Won Chai, Hyunseok Jeong, Min Kyu Song, Jae Hoon Shin, Seung-Baik Kang
INTRODUCTION: The aims of this study were to (1) assess the bone mineral density (BMD) around the knee joint, (2) determine the correlation between central and knee BMDs, and (3) investigate the factors associated with BMD around the knee joint in patients with knee osteoarthritis (OA). METHODOLOGY: This cross-sectional study included 122 patients who underwent total knee arthroplasty. Central and knee dual-energy X-ray absorptiometry was performed preoperatively...
July 19, 2018: Journal of Clinical Densitometry
Haven M Allard, Lisa Calvelli, Marcela G Weyhmiller, Ginny Gildengorin, Ellen B Fung
Interference from metal hardware (piercings; buttons on clothing; and ingested material, e.g. barium) is well documented in bone health assessments by dual-energy X-ray absorptiometry (DXA). It is unknown if iron in hepatic tissue of highly iron-loaded patients could be mistakenly assessed by DXA as bone, and if this would lead to increased areal bone mineral density (aBMD) lumbar spine Z-scores derived by DXA. Our hypothesis is that iron in the liver of heavily loaded patients will artificially raise aBMD in the spine, and thereby lead to an error in the DXA scan...
July 11, 2018: Journal of Clinical Densitometry
Adriana L Carvalho, Bianca Massaro, Luciana T P E Silva, Carlos E G Salmon, Sandra Y Fukada, Marcello H Nogueira-Barbosa, Jorge Elias, Maria C F Freitas, Carlos E B Couri, Maria C Oliveira, Belinda P Simões, Clifford J Rosen, Francisco J A de Paula
Anthropomorphic measures among type 1 diabetic patients are changing as the obesity epidemic continues. Excess fat mass may impact bone density and ultimately fracture risk. We studied the interaction between bone and adipose tissue in type 1 diabetes subjects submitted to two different clinical managements: (I) conventional insulin therapy or (II) autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST). The study comprised 3 groups matched by age, gender, height and weight: control (C = 24), type 1 diabetes (T1D = 23) and type 1 diabetes treated with AHST (T1D-AHST = 9)...
July 5, 2018: Journal of Clinical Densitometry
S Kolta, A Etcheto, J Fechtenbaum, A Feydy, C Roux, K Briot
Purpose/Introduction: Measurement of trabecular bone score (TBS® ) of the lumbar spine on dual energy X-ray absorptiometry (DXA) devices improves fracture risk prediction. We conducted a proof of concept study to assess the feasibility of TBS® measured on the low-dose imaging system EOS® . METHODS: TBS was assessed on both DXA and EOS® in 122 patients aged ≥ 50 yr, receiving no anti-osteoporotic treatment. The TBS® was computed on full-body EOS® images, focusing on the lumbar spine region...
July 4, 2018: Journal of Clinical Densitometry
Young Ho Shin, Hyun Sik Gong, Goo Hyun Baek
INTRODUCTION: Trabecular bone score (TBS) provides indirect indices of trabecular microarchitecture and bone quality. Several studies have evaluated the influence of proton pump inhibitors (PPIs) on bone mass and geometric parameters, but no studies have evaluated the influence of PPIs on TBS. METHODS: We reviewed the medical records of 1505 women aged 40-89 yr who had bone mineral density (BMD) examinations as a part of the medical diagnosis and disease prevention program and who did not have osteoporotic fractures or conditions that could affect bone metabolism...
July 4, 2018: Journal of Clinical Densitometry
N Capaldi, K T Kao, R MacDonald, K C Grainger, S Joseph, S Shepherd, A Mason, S C Wong
BACKGROUND: Interpretation of pediatric bone mineral density by dual energy absorptiometry (DXA) requires adjustment for height (Ht). This is often not easily obtainable in nonambulant subjects. AIMS: To investigate the feasibility of using DXA images to evaluate measurements of Ht, sitting height (SH), and leg length (LL). METHODOLOGY: A total of 2 observers performed measurements of Ht, SH, and LL on 3 separate occasion using DXA digital images in 125 children...
June 30, 2018: Journal of Clinical Densitometry
Manuel Muñoz-Torres, Rossana Manzanares Córdova, Antonia García-Martín, María Dolores Avilés-Pérez, Rafael Nieto Serrano, Francisco Andújar-Vera, Beatriz García-Fontana
BACKGROUND: Patients with primary hyperparathyroidism usually show decreased bone strength that are often not well diagnosed by conventional Dual-energy X-ray absorptiometry (DXA). Trabecular Bone Score (TBS) is a new technique for assessing bone microarchitecture indirectly. This cross-sectional study evaluates the usefulness of TBS in patients with primary hyperparathyroidism in clinical practice. METHODOLOGY: Bone mineral density (BMD) by DXA and TBS values by TBS InSight® software were determined in 72 patients with primary hyperparathyroidism to analyze its relationship with fragility fractures...
June 27, 2018: Journal of Clinical Densitometry
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