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Aging Male: the Official Journal of the International Society for the Study of the Aging Male

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https://www.readbyqxmd.com/read/30193547/association-of-vitamin-d-status-and-the-risk-of-cardiovascular-disease-as-assessed-by-various-cardiovascular-risk-scoring-systems-in-patients-with-type-2-diabetes-mellitus
#1
Rıdvan Sivritepe, Sema Basat, Damla Ortaboz
OBJECTIVE: The aim of the present study was to evaluate the relationship between vitamin D (25[OH]D) status and the risk of cardiovascular disease as assessed by various cardiovascular risk scoring systems such as QRISK2, BNF, ASSING, SCORE, and Framingham in patients with type 2 diabetes mellitus(T2DM). METHODS: The study included 108 patients with vitamin D insufficiency (25[OH]D ≥ 10-30 ng/mL) and 100 patients with vitamin D deficiency (25[OH]D < 10 ng/mL), who were admitted to the diabetes outpatient clinics due to T2DM and who were aged 45-65 years...
September 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30193541/enzyme-immunoassay-may-be-inadequate-for-measuring-salivary-testosterone-in-older-men
#2
Allan Mazur, Soazig Clifton
Several correlations have been reported between men's testosterone (T) and other characteristics. Stalwart findings are a decline in T during the day, decline with obesity, and decline with advancing age. Here seven previously reported correlations are tested among older American men in the National Social Life, Health and Aging Project (NSHAP), their salivary T measured by enzyme immunoassays (EIA). Few significant correlations are found, with most tests producing weak or null results. These findings, overall, suggest that T does not "work" much among older men...
September 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30193537/expression-of-sex-steroid-receptors-and-aromatase-in-adipose-tissue-in-different-body-regions-in-men-with-coronary-artery-disease-with-and-without-ischemic-systolic-heart-failure
#3
Elżbieta Kalicińska, Katarzyna Wojtas, Jacek Majda, Maciej Zacharski, Jacek Skiba, Jan Śliwowski, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
BACKGROUND: The hormonal metabolism of adipose tissue differs across regions of fat. This issue has never been verified in male patients with coronary artery disease (CAD) with and without systolic heart failure (SHF). METHODS: We examined 90 male patients with CAD with and without SHF and 42 healthy controls. RESULTS: In patients with CAD with and without SHF, androgen receptor (AR) expression in adipose tissue of the lower leg was higher than AR expression of the thoracic wall and epicardial adipose tissue (EAT) (both p < ...
September 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30146916/comparative-study-of-the-effects-of-osteoprotegerin-and-testosterone-on-bone-quality-in-male-orchidectomised-rats
#4
Marta Martín-Fernández, Francisco-Miguel Garzón-Márquez, Manuel Díaz-Curiel, Iván Prieto-Potin, Luis Alvarez-Galovich, David Guede, Jose Ramón Caeiro-Rey, Concepción De la Piedra
AIM: The aim of this work is to compare the effects of osteoprotegerin (OPG) and testosterone on bone quality in a model of orchidectomised (ORX) rats. METHODS: Three-month-old ORX or SHAM operated groups (n = 15 each group) were used. The SHAM and ORX groups received saline. There were two ORX groups, receiving OPG-Fc (10 mg/kg twice weekly) (ORX + OPG-Fc) or testosterone cypionate (1.7 mg/kg/weekly) for 8 weeks. After sacrifice, bone analysis by femoral and lumbar dual-energy X-ray absorptiometry and micro-computed tomography in femora were performed...
August 25, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30084276/no-association-of-serum-psa-with-vitamin-d-or-total-oxidant-antioxidant-capacity-in-healthy-men
#5
Burak Toprak, Ayfer Colak, Hulya Yalcin, Mustafa Yildirim
BACKGROUND AND AIM: Vitamin D deficiency and oxidative stress were suggested to be related to prostate cancer risk. We aimed to investigate the association of serum PSA concentration with vitamin D and total oxidant/antioxidant levels. MATERIALS AND METHODS: A total of 95 healthy men were enrolled for the cross sectional study. Serum PSA, 25(OH)D, serum total oxidant status, and total antioxidant status were measured. RESULTS: Serum PSA was significantly negatively correlated with serum total oxidant status (r= -0...
August 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30081749/prevalence-of-andropause-among-iranian-men-and-its-relationship-with-quality-of-life
#6
Nazanin Rezaei, Arman Azadi, Reza Pakzad
INTRODUCTION: Andropause is a complicated process in men's life which can negatively affect their quality of life in both physical and psychological dimensions. OBJECTIVES: The aim of this study was to determine the prevalence of andropause among Iranian men age 40-85 years and its relationship with quality of life. MATERIALS AND METHODS: This was a cross-sectional study among 393 men attending ten urban healthcare centers in Ilam province in southwestern Iran...
August 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30064288/urogenital-dysfunction-in-male-patients-with-charcot-marie-tooth-a-systematic-review
#7
Rossella Cannarella, Giovanni Burgio, Enzo S Vicari, Sandro La Vignera, Rosita A Condorelli, Aldo E Calogero
INTRODUCTION: Charcot-Marie-Tooth (CMT) is the most common inherited polyneuropathy. Polyneuropathies are likely to affect the urogenital system. Urogenital dysfunction is rarely investigated and may be underestimated in CMT patients. AIM: The aim of the present study was to perform a systematic review of the literature to collect all the available evidence on the presence of urogenital dysfunction and in patients with CMT. METHODS: Data sources were MEDLINE, Pubmed, Scopus, and Google Scholar...
July 31, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30064273/hypogonadism-and-its-treatment-following-ischaemic-stroke-in-men-with-type-2-diabetes-mellitus
#8
L Y Morgunov, I A Denisova, T I Rozhkova, L V Stakhovskaya, V I Skvortsova
Premature mortality in Russia is a major socio-economic problem, especially from acute cerebrovascular diseases which constitute 21.4% of the total mortality and is a considerable contributor to chronic disability. Risk of vascular catastrophe is higher in males than females, thought, in part, due to anti-atherosclerotic effects of oestrogens in females whilst an associated age-related deficiency of testosterone is observed in men. Clinical symptoms such as high blood pressure, changes in lipid profile, insulin resistance, obesity, and blood coagulation factors often accompany declining testosterone in males and reduced total testosterone is considered a cardiovascular risk factor...
July 31, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30058422/hyperlipidemia-patients-with-long-term-statin-treatment-are-associated-with-a-reduced-risk-of-progression-of-benign-prostatic-enlargement
#9
Hung-Jen Shih, Pei-Shan Tsai, Yu-Ching Wen, Ming-Chang Kao, Yen-Chun Fan, Chun-Jen Huang
OBJECTIVE: To evaluate the impacts of statin treatment on the risk of benign prostatic enlargement (BPE) progression in hyperlipidemia patients. METHODS: Newly diagnosed hyperlipidemia patients (n = 7961), identified from Taiwan's National Health Insurance Research Database, were divided into four statin cohorts (statin use >365 days, n = 1604; statin use 181-365 days, n = 813; statin use 91-180 days, n = 739; and statin use 31-90 days, n = 713) and one control cohort (cohort that used no statins, n = 4092)...
July 28, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30040004/quality-of-life-and-sexual-health-in-men-with-prostate-cancer-undergoing-radical-prostatectomy
#10
Angela M E P Naccarato, Sophia Consuelo Souto, Wagner E Matheus, Ubirajara Ferreira, Fernandes Denardi
The aim of this study was to evaluate the relationship between quality of life, erectile function and group psychotherapy in patients with prostate cancer undergoing radical prostatectomy. Sixty patients were evaluated for erectile function (IIEF-5), quality of life (SF-36SF), urinary incontinence (ICQI-SF and ICQI-OAB). Thirty of them had group psychotherapy two weeks before and 12 weeks after surgery. Patients who underwent group psychotherapy had better scores in IIEF-5, satisfaction with life in general, satisfaction with sexual life and in partner relationship; better results of SF-36SF, excepting two domains: bodily pain and role emotional...
July 24, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30039993/testosterone-level-in-aging-male-with-different-glucose-tolerance-state-and-its-association-with-osteocalcin
#11
Yanhui Lu, Jian Li, Xiaoling Cheng, Nan Li, Xinyu Miao, Banruo Sun, Shuangtong Yan, Chunlin Li
OBJECTIVE: To investigate the relationship of testosterone and different glucose tolerance state, and its association with osteocalcin. METHODS: A cross-sectional study was conducted of 1176 males aged 60-97 years who were arranged for an annual regular checkup from March to May 2012 in Chinese PLA general hospital in Beijing. RESULTS: Individuals categorized as having prediabetes or diabetes were more likely to have lower osteocalcin, testosterone, and SHBG levels compared to those with normal glucose tolerance (p < ...
July 24, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/30039982/a-randomized-controlled-study-of-treatment-with-ojayeonjonghwan-for-patients-with-late-onset-hypogonadism
#12
Kyu Won Lee, Sang Rak Bae, Hyun Cheol Jeong, Jin Bong Choi, Sae Woong Choi, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Sae Woong Kim
OBJECTIVES: We investigate the effects of Ojayeonjonghwan (KH-204) in men with late-onset hypogonadism (LOH) symptoms. MATERIAL AND METHODS: Initial PSA, testosterone, lipid profile and questionnaires about LOH-related symptoms were checked. After 8 weeks of the treatment (control or KH-204), questionnaires and serological tests were repeated to evaluate the efficacy of the agent. The changes of variables in each group and the difference between two groups were compared...
July 24, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29993302/effect-of-senescence-on-morphological-functional-and-oxidative-features-of-fresh-and-cryopreserved-canine-sperm
#13
Maíra Morales Brito, Daniel de Souza Ramos Angrimani, Bruno Rogério Rui, Giulia Kiyomi Vechiato Kawai, João Diego Agostini Losano, Camila Infantosi Vannucchi
The present research aimed to compare the hormonal profile, sperm quality and freezability of young and senile dogs. Dogs were assigned into Young Group (n = 11) and Senile Group (n = 11), additionally divided into Fresh Semen Group and Cryopreserved Semen Group. Males were evaluated for libido score and blood estrogen and testosterone assay. Sperm morphofunctional evaluations were performed based on Computer Assisted Sperm Analysis, morphology, mitochondrial activity, mitochondrial membrane potential, plasma and acrosomal membrane integrity, and DNA fragmentation...
July 11, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29985721/novel-symptom-questionnaire-for-the-differential-diagnosis-of-detrusor-underactivity-and-bladder-outlet-obstruction-in-men
#14
Aram Kim, Young-Jin Park, Kyung Ok Heo, Woo Suk Choi, Hyoung Keun Park, Sung Hyun Paick, Myung-Soo Choo, Hyeong Gon Kim
OBJECTIVE: To develop a questionnaire for the differential diagnosis of detrusor underactivity (DUA) and bladder outlet obstruction (BOO) without performing invasive pressure flow studies. STUDY DESIGN AND METHODS: Symptoms of men with DUA were analyzed and compared with those of men with BOO using eight questions from the developing questionnaire. Patients with DUA have a bladder contractility index (PdetQmax+5xQmax) less than 100, whereas those with BOO have a BOO index (PdetQmax-2xQmax) greater than 40 in urodynamic studies (UDS)...
July 9, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29950140/consequences-on-aging-process-and-human-wellness-of-generation-of-nitrogen-and-oxygen-species-during-strenuous-exercise
#15
Francesco Sessa, Giovanni Messina, Raffaele Russo, Monica Salerno, Carlo Castruccio Castracani, Alfio Distefano, Giovanni Li Volti, Aldo E Calogero, Rossella Cannarella, Laura M Mongioi', Rosita A Condorelli, Sandro La Vignera
Impairment of antioxidant defense system and increase in metabolic rate and production of reactive oxygen species have been demonstrated in strenuous exercise. Both at rest and during contractile activity, skeletal muscle generates a very complex set of reactive nitrogen and oxygen species; the main generated are superoxide and nitric oxide. The nature of the contractile activity influences the pattern and the magnitude of this reactive oxygen and nitrogen species (ROS) generation. The intracellular pro-oxidant/antioxidant homeostasis undergoes alteration owing to strenuous exercise and the major identified sources of intracellular free radical generation during physical activity are the mitochondrial electron transport chain, polymorphoneutrophil, and xanthine oxidase...
June 27, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29950136/life-quality-change-after-inflatable-penile-prosthesis-implantation
#16
Iyimser Ure, Ata Ozen, Cavit Can
PURPOSE: It was aimed to evaluate the changes in quality of life in patients with erectile dysfunction (ED) after inflatable penile prosthesis implantation. MATERIAL AND METHODS: Forty-one patients who underwent to an inflatable penile prosthesis implantation surgery due to ED were included in the study. The age of the patients, the indications for surgery, and the type of prosthesis implanted were recorded. All patients were implanted two-piece inflatable (AMS Ambicor™) or three-piece inflatable (AMS 700™) prostheses...
June 27, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29944060/the-effect-of-air-dust-pollution-on-semen-quality-and-sperm-parameters-among-infertile-men-in-west-of-iran
#17
Ali Najafpour, Faranak Aghaz, Shiva Roshankhah, Mitra Bakhtiari
BACKGROUND: Pollutants during haze and Asian dust storms are transported out of the Asian continent, affecting the regional climate and the hydrological and biogeochemical cycles. Nonetheless, no specific studies evaluated the dust particles influence on semen quality in a specific geographical area. OBJECTIVE: In this article, we investigated the effect of dust particles on semen quality and sperm parameters among infertile men. METHODS: A descriptive-analytic study was conducted among 850 infertile men between 2011 and 2015 years...
June 26, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29944055/evaluation-of-the-relationship-between-microalbuminuria-and-25-oh-vitamin-d-levels-in-patients-with-type-2-diabetes-mellitus
#18
Sema Ucak, Ecem Sevim, Damla Ersoy, Rıdvan Sivritepe, Okcan Basat, Sabri Atay
BACKGROUND: 25-(OH) vitamin D (VD) deficiency has been described as potential risk factor for the development of diabetes in many epidemiological studies. 25-(OH) VD deficiency and insulin resistance associated with this deficiency are common findings in patients with type 2 diabetes mellitus. The objective of this study is to evaluate the relationship between 25-(OH) VD levels and microalbuminuria. METHODS: The patients with type 2 diabetes mellitus aged between 40 and 65 years, who were admitted to the diabetes outpatient clinics of our hospital, were evaluated in two different groups...
June 26, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29863448/inverse-association-of-testosterone-and-sex-hormone-binding-globulin-levels-with-leukocyte-count-in-middle-aged-and-elderly-men
#19
Byoungjin Park, Yong-Jae Lee
OBJECTIVE: The inverse associations of testosterone and sex hormone-binding globulin (SHBG) levels with cardiometabolic diseases are well established and are increasingly viewed as inflammatory diseases. This study aimed to examine the associations of testosterone and SHBG levels with leukocyte count in 451 Korean men aged ≥50 years. METHODS: Serum testosterone and SHBG levels were categorized into tertiles. High leukocyte count was defined as ≥7340 cells/μl, which corresponded to the 75th percentile of the current sample...
September 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29734846/the-efficacy-and-safety-of-short-acting-testosterone-ointment-glowmin-for-late-onset-hypogonadism-in-accordance-with-testosterone-circadian-rhythm
#20
Toshiyasu Amano, Teruaki Iwamoto, Yoshikazu Sato, Tetsuya Imao, Carolyn Earle
INTRODUCTION: It is well known that there is a reduction of circadian rhythm in blood testosterone levels with aging. Our previous report revealed that 3 mg of short-acting testosterone ointment (Glowmin: GL) elevated serum testosterone levels to within the physiological range for 4-6 h. The aim of this study was to clarify the clinical efficacy and safety of GL used topically once every morning, to enhance the circadian rhythm of testosterone, for late-onset hypogonadism (LOH). METHODS: A total of 61 LOH patients received 3 mg of GL topically once a day in the morning on scrotal skin for 24 weeks...
September 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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