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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/27914212/proposed-classification-for-a-variant-of-kounis-syndrome
#1
Tomonori Itoh, Yoshifumi Nakajima, Yoshihiro Morino
No abstract text is available yet for this article.
December 3, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27914211/micrornas-in-cardiovascular-disease-clinical-application
#2
Christian Schulte, Mahir Karakas, Tanja Zeller
microRNAs (miRNAs) are well-known, powerful regulators of gene expression, and their potential to serve as circulating biomarkers is widely accepted. In cardiovascular disease (CVD), numerous studies have suggested miRNAs as strong circulating biomarkers with high diagnostic as well as prognostic power. In coronary artery disease (CAD) and heart failure (HF), miRNAs have been suggested as reliable biomarkers matching up to established protein-based such as cardiac troponins (cT) or natriuretic peptides. Also, in other CVD entities, miRNAs were identified as surprisingly specific biomarkers - with great potential for clinical applicability, especially in those entities that lack specific protein-based biomarkers such as atrial fibrillation (AF) and acute pulmonary embolism (APE)...
December 3, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27898400/complex-considerations-when-tendering-for-hba1c-analysers
#3
William Patrick Tormey, Brendan Byrne, Conor Russell, Geraldine Collier, Seamus Sreenan
No abstract text is available yet for this article.
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27898399/evaluation-of-an-automated-commercial-elisa-method-for-calprotectin-determination-in-pleural-fluid
#4
Lorena Vázquez-Iglesias, Pedro Casado-Rey, Maribel Botana-Rial, María Amalia Andrade-Olivié, Francisco Javier Rodriguez-Berrocal, María Páez de la Cadena, Alberto Fernández-Villar
No abstract text is available yet for this article.
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27898398/pseudohyperkalemia-in-capillary-whole-blood-samples-an-occasional-error-or-a-significant-problem-in-a-pediatric-hospital
#5
Olga Ciepiela, Agata Raniszewska, Aneta Manda-Handzlik, Iwona Kotuła, Urszula Demkow
No abstract text is available yet for this article.
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27898397/multicenter-performance-evaluation-of-a-second-generation-cortisol-assay
#6
Michael Vogeser, Jürgen Kratzsch, Yoon Ju Bae, Mathias Bruegel, Uta Ceglarek, Tom Fiers, Alexander Gaudl, Hedwig Kurka, Christoph Milczynski, Cristina Prat Knoll, Anna C Suhr, Daniel Teupser, Ingrid Zahn, Richard E Ostlund
BACKGROUND: Untreated disorders of the adrenocortical system, such as Cushing's or Addison's disease, can be fatal, and accurate quantification of a patient's cortisol levels is vital for diagnosis. The objective of this study was to assess the analytical performance of a new fully-automated Elecsys® Cortisol II assay (second generation) to measure cortisol levels in serum and saliva. METHODS: Four European investigational sites assessed the intermediate precision and reproducibility of the Cortisol II assay (Roche Diagnostics) under routine conditions...
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27879483/comparison-of-ex-vivo-stability-of-copeptin-and-vasopressin
#7
Judith E Heida, Lianne S M Boesten, Esmée M Ettema, Anneke C Muller Kobold, Casper F M Franssen, Ron T Gansevoort, Debbie Zittema
BACKGROUND: Copeptin, part of the vasopressin precursor, is increasingly used as marker for vasopressin and is claimed to have better ex vivo stability. However, no study has directly compared the ex vivo stability of copeptin and vasopressin. METHODS: Blood of ten healthy volunteers was collected in EDTA tubes. Next, we studied the effect of various pre-analytical conditions on measured vasopressin and copeptin levels: centrifugation speed, short-term storage temperature and differences between whole blood and plasma, long-term storage temperature and repeated freezing and thawing...
November 23, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27866173/a-rapid-uplc-ms-ms-assay-for-the-simultaneous-measurement-of-fluconazole-voriconazole-posaconazole-itraconazole-and-hydroxyitraconazole-concentrations-in-serum
#8
Sankha S Basu, Athena Petrides, Donald S Mason, Petr Jarolim
BACKGROUND: Triazole antifungals are essential to the treatment and prophylaxis of fungal infections. Significant pharmacokinetic variability combined with a clinical need for faster turnaround times has increased demand for in-house therapeutic drug monitoring of these drugs, which is best performed using mass spectrometry-based platforms. However, technical and logistical obstacles to implementing these platforms in hospital laboratories have limited their widespread utilization. Here, we present the development and validation of a fast and simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to measure fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole in human serum suitable for incorporation into a hospital clinical laboratory...
November 21, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27855116/role-of-activated-platelets-in-severe-acne-scarring-and-adaptive-immunity-activation
#9
Sidra Younis, Fiza Rana, Miroslav Blumenberg, Qamar Javed
No abstract text is available yet for this article.
November 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27855115/infrared-analysis-of-lipoproteins-in-the-detection-of-alcohol-biomarkers
#10
Sander De Bruyne, Tinne Monteyne, Marijn M Speeckaert, Joris R Delanghe
BACKGROUND: Alcoholism is a major public health problem. Alcohol causes modifications in the composition and concentration of lipoproteins and influences the enzymes and transfer proteins that transform lipoproteins in plasma. Alcohol is associated with the presence of alcohol biomarkers (fatty acid ethyl esters [FAEEs] and phosphatidylethanol [PEth]) in lipoproteins. We explore the possibilities of detecting alcohol biomarkers in non-high-density-lipoproteins (non-HDLs) precipitated from serum using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR)...
November 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27845880/alkaline-phosphatase-activity-ph-impact-on-the-measurement-result
#11
Denis Grote-Koska, Rainer Klauke, Korbinian Brand, Gerhard Schumann
No abstract text is available yet for this article.
November 15, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27845879/quality-control-materials-for-pharmacogenomic-testing-in-the-clinic
#12
Guigao Lin, Kuo Zhang, Yanxi Han, Jinming Li
Pharmacogenomics has significantly added to our understanding of drug responses in clinical pharmacology, changing the paradigm of treatment decisions. Interrogations of both inherited and somatic variations for therapeutic purposes are increasingly being adopted in clinics, where quality control (QC) materials are required. However, for many pharmacogenomic tests, the acquisition of well-characterized QC materials is often difficult or impossible. In this review, several sources of appropriate QC materials for therapy-associated genetic testing are discussed...
November 15, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27837595/serological-diagnosis-and-prognosis-of-severe-acute-pancreatitis-by-analysis-of-serum-glycoprotein-2
#13
Dirk Roggenbuck, Alexander Goihl, Katja Hanack, Pamela Holzlöhner, Christian Hentschel, Miklos Veiczi, Peter Schierack, Dirk Reinhold, Hans-Ulrich Schulz
BACKGROUND: Glycoprotein 2 (GP2), the pancreatic major zymogen granule membrane glycoprotein, was reported to be elevated in acute pancreatitis in animal models. METHODS: Enzyme-linked immunosorbent assays (ELISAs) were developed to evaluate human glycoprotein 2 isoform alpha (GP2a) and total GP2 (GP2t) as specific markers for acute pancreatitis in sera of 153 patients with acute pancreatitis, 26 with chronic pancreatitis, 125 with pancreatic neoplasms, 324 with non-pancreatic neoplasms, 109 patients with liver/biliary disease, 67 with gastrointestinal disease, and 101 healthy subjects...
November 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27837594/advances-in-laboratory-diagnosis-of-hereditary-spherocytosis
#14
Mariela Granero Farias
Among the red cell membrane disorders, hereditary spherocytosis (HS) is one of the most common causes of inherited hemolytic anemia. HS results from the deficiency or dysfunction of red blood cell membrane proteins, such as α spectrin, β spectrin, ankyrin, anion channel protein (Band-3 protein), protein 4.1 and protein 4.2. Conventionally, HS diagnosis is established through a series of tests, which include spherocytes identification in peripheral smear, reticulocyte count, osmotic fragility, etc. Currently, different hematological analyzers provide erythrocyte indicators that estimate the presence of spherocytes and correlate that with HS, which can be useful for disease screening...
November 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27831917/25-hydroxyvitamin-d-threshold-values-should-be-age-specific
#15
Lilian Mello Soares, William Pedrosa, Silvana Maria Elói-Santos, Leonardo Souza Vasconcellos
No abstract text is available yet for this article.
November 10, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27831916/retrospective-evaluation-of-the-clinical-utility-of-serological-biomarkers-in-chinese-patients-with-inflammatory-bowel-disease-2-year-clinical-experience
#16
Shulan Zhang, Jing Luo, Ji Li, Ziyan Wu, Chaojun Hu, Ping Li, Chuiwen Deng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
BACKGROUND: Antibodies to saccharomyces cerevisiae (ASCA), antibodies to perinuclear anti-neutrophil cytoplasmic (pANCA), pancreatic autoantibodies (PAB) and antibodies against intestinal goblet cells (GAB) are important in diagnosing Crohn's disease (CD) and ulcerative colitis (UC). However, little is known about their diagnostic value in real clinical practice in China. This retrospective study aimed to present our 2-year clinical experience with those biomarkers in diagnosis of CD and UC...
November 10, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27816960/effect-of-dabigatran-treatment-at-therapeutic-levels-on-point-of-care-international-normalized-ratio-inr
#17
Elisabeth Sellevoll Løkkebø, Ann Helen Kristoffersen, Anne Stavelin, Una Ørvim Sølvik
No abstract text is available yet for this article.
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27816959/ct-or-mri
#18
Mesut Tez
No abstract text is available yet for this article.
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27816958/urinary-orosomucoid-a-novel-early-biomarker-of-sepsis-with-promising-diagnostic-performance
#19
Péter Kustán, Balázs Szirmay, Zoltán Horváth-Szalai, Andrea Ludány, Gábor L Kovács, Attila Miseta, Tamás Kőszegi, Diána Mühl
BACKGROUND: In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters. METHODS: We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow-up study vs. control patients (n=30). U-ORM was measured by a newly developed turbidimetric assay. U-ORM values were referred to urinary creatinine and expressed as u-ORM/u-CREAT (mg/mmol)...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27816957/estimating-the-intra-and-inter-individual-imprecision-of-manual-pipetting
#20
Giuseppe Lippi, Gabriel Lima-Oliveira, Giorgio Brocco, Antonella Bassi, Gian Luca Salvagno
BACKGROUND: Despite the importance of manual pipetting of fluids such as water, solutions, buffers, reagents, or biological samples in daily laboratory practice, the intra- and inter-individual imprecision of this activity has not been recently described in scientific publications. METHODS: Twenty laboratory operators were randomly enrolled for this study. Imprecision of manual pipetting was estimated by asking each laboratory professional to dispense 1 mL, 100 μL or 10 μL of distilled water for 10 consecutive times with three certified pipettes into a 50-mL plastic container placed into a gravimetric balance...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
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