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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/28493816/sample-types-applied-for-molecular-diagnosis-of-therapeutic-management-of-advanced-non-small-cell-lung-cancer-in-the-precision-medicine
#1
Yanxi Han, Jinming Li
In this era of precision medicine, molecular biology is becoming increasingly significant for the diagnosis and therapeutic management of non-small cell lung cancer. The specimen as the primary element of the whole testing flow is particularly important for maintaining the accuracy of gene alteration testing. Presently, the main sample types applied in routine diagnosis are tissue and cytology biopsies. Liquid biopsies are considered as the most promising alternatives when tissue and cytology samples are not available...
May 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28467311/terminology-of-cardiac-troponin-assays-and-data-censoring
#2
Petr Jarolim
We discuss the sensitivity terminology of cardiac troponin assays and its dependence on the selection of the reference population. In addition, the need for reasonable censoring of clinical laboratory test results is contrasted with potential loss of valuable clinical information.
May 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28467310/use-of-ifcc-guidelines-to-verify-acetylcholinesterase-reference-interval-in-adults-determined-with-che-check-mobile-testing-system
#3
LETTER
Bertrand Lefrere, Aurélie Servonnet, Franck Ceppa, Fréderic Dorandeu, Hervé Delacour
No abstract text is available yet for this article.
May 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28467309/automated-antinuclear-immunofluorescence-antibody-analysis-is-a-reliable-approach-in-routine-clinical-laboratories
#4
Bing Zheng, Enling Li, Haoming Zhu, Jingbo Lu, Xinming Shi, Jie Zhang, Min Li
BACKGROUND: Indirect immunofluorescence (IIF) assays are recommended as the gold standard method for the detection of antinuclear antibodies (ANAs). This study aimed to investigate the reliability of an automated system. METHODS: We compared 3745 serum samples using NOVA View archived images with manual analysis via microscopy. A custom cutoff value was established to distinguish ANA titers and was validated in two clinical laboratories. The automatic ANA pattern recognition system was evaluated, and all ANA-positive sera were subjected to two commercial ANA IIF kits to compare the consistency of the pattern interpretation results...
May 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28467308/thyroglobulin-autoantibodies-before-radioiodine-ablation-predict-differentiated-thyroid-cancer-outcome
#5
Pierpaolo Trimboli, Valentina Zilioli, Mauro Imperiali, Luca Giovanella
BACKGROUND: Serum thyroglobulin (Tg) is essential to manage differentiated thyroid carcinoma (DTC). However, Tg determination is affected by circulating Tg antibodies (TgAb), and a role of TgAb as surrogate biomarker has been proposed. Here we evaluated the role of TgAb measured before and after radioiodine ablation (RRA) as potential predictors of prognosis. METHODS: Patients treated since 2006 were screened. Cancers with structural relapse were defined as recurrent...
May 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28453439/evaluation-of-serum-cortisol-biological-variation-in-the-evening-withdrawal
#6
LETTER
Ruggero Dittadi, Alessandro Fiorin Damiani, Chiara Olcese
No abstract text is available yet for this article.
April 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28453438/low-levels-of-25-oh-vitamin-d-in-women-with-endometriosis-and-associated-pelvic-pain
#7
LETTER
Emanuela Anastasi, Eliana Fuggetta, Corrado De Vito, Giuseppe Migliara, Valentina Viggiani, Lucia Manganaro, Teresa Granato, Pierluigi Benedetti Panici, Antonio Angeloni, Maria Grazia Porpora
No abstract text is available yet for this article.
April 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28448271/separate-patient-serum-sodium-medians-from-males-and-females-provide-independent-information-on-analytical-bias
#8
Steen Ingemann Hansen, Per Hyltoft Petersen, Flemming Lund, Callum G Fraser, György Sölétormos
BACKGROUND: During monitoring of monthly medians of results from patients undertaken to assess analytical stability in routine laboratory performance, the medians for serum sodium for male and female patients were found to be significantly related. METHODS: Daily, weekly and monthly patient medians of serum sodium for both male and female patients were calculated from results obtained on samples from the population >18 years on three analysers in the hospital laboratory...
April 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432845/effect-of-age-on-serum-prostate-specific-antigen-in-women
#9
LETTER
Eleftherios P Diamandis, Emma Eklund, Carla Muytjens, Clare Fiala, Sarah Wheeler, Galina Nikolenko, Anu Mathew, Martin Stengelin, Eli Glezer, Marshall D Brown, Yingye Zheng, Angelica Lindén Hirschberg
No abstract text is available yet for this article.
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432844/evaluating-new-hba1c-methods-for-adoption-by-the-ifcc-and-ngsp-reference-networks-using-international-quality-targets
#10
Erna Lenters-Westra, Emma English
BACKGROUND: As a reference laboratory for HbA1c, it is essential to have accurate and precise HbA1c methods covering a range of measurement principles. We report an evaluation of the Abbott Enzymatic (Architect c4000), Roche Gen.3 HbA1c (Cobas c513) and Tosoh G11 using different quality targets. METHODS: The effect of hemoglobin variants, other potential interferences and the performance in comparison to both the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the National Glycohemoglobin Standardization Program (NGSP) reference systems was assessed using certified evaluation protocols...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432843/vitamin-b1-in-critically-ill-patients-needs-and-challenges
#11
REVIEW
Jake T B Collie, Ronda F Greaves, Oliver A H Jones, Que Lam, Glenn M Eastwood, Rinaldo Bellomo
BACKGROUND: Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS). This review aims to explore analytical methodologies of thiamine compound quantification and highlight similarities, variances and limitations of current techniques and how they may be relevant to patients. CONTENT: An electronic search of Medline, PubMed and Embase databases for original articles published in peer-reviewed journals was conducted...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432842/low-grade-inflammation-and-tryptophan-kynurenine-pathway-activation-are-associated-with-adverse-cardiac-remodeling-in-primary-hyperparathyroidism-the-epath-trial
#12
Nicolas Verheyen, Andreas Meinitzer, Martin Robert Grübler, Klemens Ablasser, Ewald Kolesnik, Astrid Fahrleitner-Pammer, Evgeny Belyavskiy, Christian Trummer, Verena Schwetz, Elisabeth Pieske-Kraigher, Jakob Voelkl, Ioana Alesutan, Cristiana Catena, Leonardo Alberto Sechi, Helmut Brussee, Dirk von Lewinski, Winfried März, Burkert Pieske, Stefan Pilz, Andreas Tomaschitz
BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with low-grade inflammation, left ventricular hypertrophy and increased cardiovascular mortality, but the association between inflammatory markers and parameters of adverse cardiac remodeling is unknown. We investigated the relationship between C-reactive protein (CRP), the essential amino acid tryptophan and its pro-inflammatory derivatives kynurenine and quinolinic acid (QUIN) with echocardiographic parameters. METHODS: Cross-sectional baseline data from the "Eplerenone in Primary Hyperparathyroidism" trial were analyzed...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432841/comparison-of-pneumatic-tube-system-with-manual-transport-for-routine-chemistry-hematology-coagulation-and-blood-gas-tests
#13
Alex Pupek, Beverly Matthewson, Erin Whitman, Rachel Fullarton, Yu Chen
BACKGROUND: The pneumatic tube system (PTS) is commonly used in modern clinical laboratories to provide quick specimen delivery. However, its impact on sample integrity and laboratory testing results are still debatable. In addition, each PTS installation and configuration is unique to its institution. We sought to validate our Swisslog PTS by comparing routine chemistry, hematology, coagulation and blood gas test results and sample integrity indices between duplicate samples transported either manually or by PTS...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28432840/detection-of-egfr-mutations-in-patients-with-non-small-cell-lung-cancer-by-high-resolution-melting-comparison-with-other-methods
#14
Carlos Martínez-Carretero, Fernando Iguaz Pascual, Antonio Rus, Ivan Bernardo
BACKGROUND: The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensitivity and potential ability to detect a different number of mutations. METHODS: We developed a screening method by high resolution melting (HRM) to detect EGFR mutations, and compared the results of 123 fixed in formalin and paraffin embedded (FFPE) tumor tissue samples with the detection of mutations by allele-specific PCR...
April 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426431/automated-detection-of-unstable-hemoglobin-variants-by-sysmex-xe-series-analyzers
#15
LETTER
Cláudia Teixeira, Daniela Pina, Maria Inês Freitas
No abstract text is available yet for this article.
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426430/great-need-for-changes-in-higher-education-in-greece
#16
LETTER
Ioannis Bakoyiannis, Veroniki Cherdyntseva, Maria Aivalioti, Maria Barton, Davide Coda, Ioanna Douka, Angelina Evangelou, Christos Evangelou, Petros Ioannou, Vasiliki Kanta, Konstantinos Kapanidis, Ioannis Karagiannidis, Damianos Kokkinidis, Sofia Kouni, Jamie Lehnen, Andreas Patsalos, Julian Pei, Peristera-Ioanna Petropoulou, William Rodemer, Diego Scerbo, Alketa Stefa, Elizar Tsvetkov, Lazaros Vasilikos, Themistoklis Vasilopoulos, Aleksandra Vukojicic, Efthalia Zafeiropoulou
No abstract text is available yet for this article.
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426429/a-candidate-liquid-chromatography-mass-spectrometry-reference-method-for-the-quantification-of-the-cardiac-marker-1-32-b-type-natriuretic-peptide
#17
Attila F Torma, Kate Groves, Sabine Biesenbruch, Chris Mussell, Alan Reid, Steve Ellison, Rainer Cramer, Milena Quaglia
BACKGROUND: B-type natriuretic peptide (BNP) is a 32 amino acid cardiac hormone routinely measured by immunoassays to diagnose heart failure. While it is reported that immunoassay results can vary up to 45%, no attempt of standardization and/or harmonization through the development of certified reference materials (CRMs) or reference measurement procedures (RMPs) has yet been carried out. METHODS: B-type natriuretic peptide primary calibrator was quantified traceably to the International System of Units (SI) by both amino acid analysis and tryptic digestion...
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412721/are-admission-procalcitonin-levels-universal-mortality-predictors-across-different-medical-emergency-patient-populations-results-from-the-multi-national-prospective-observational-triage-study
#18
Ramon Sager, Yannick Wirz, Devendra Amin, Adina Amin, Pierre Hausfater, Andreas Huber, Sebastian Haubitz, Alexander Kutz, Beat Mueller, Philipp Schuetz
BACKGROUND: Procalcitonin (PCT), an inflammatory blood biomarker, is well studied in infectious diseases. Its prognostic value in unselected emergency department (ED) patients remains yet undefined. Herein, we investigated association of admission PCT levels and mortality in a large, international-multicenter ED patient cohort. METHODS: We prospectively enrolled 6970 unselected, consecutive, adult, medical patients seeking ED care in three tertiary-care hospitals in Switzerland, France and the USA...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412720/mean-hemoglobin-concentrations-in-fasting-venous-and-non-fasting-capillary-blood-of-cambodian-women-using-a-hemoglobinometer-and-an-automated-hematology-analyzer
#19
LETTER
Crystal D Karakochuk, Aviva I Rappaport, Susan I Barr, Tim J Green
No abstract text is available yet for this article.
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412719/combined-measurement-of-factor-xiii-and-d-dimer-is-helpful-for-differential-diagnosis-in-patients-with-suspected-pulmonary-embolism
#20
Ning Tang, Ziyong Sun, Dengju Li, Jun Yang, Shiyu Yin, Qing Guan
BACKGROUND: D-dimer has been used to rule out pulmonary embolism (PE). Based on previous reports of decreased concentrations of coagulation factor XIII (FXIII) in venous thromboembolism, and no change in FXIII concentration in patients with acute cardiovascular disease, we evaluated the benefit of simultaneously measuring D-dimer and FXIII concentrations for diagnosing PE. METHODS: In this prospective single-center study, we enrolled 209 patients initially suspected of having PE, and measured their D-dimer and FXIII concentrations...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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