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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/28628475/predictive-autoimmunity-using-autoantibodies-screening-for-anti-nuclear-antibodies
#1
Dolores Pérez, Boris Gilburd, Óscar Cabrera-Marante, Jose A Martínez-Flores, Manuel Serrano, Laura Naranjo, Daniel Pleguezuelo, Luis Morillas, Ora Shovman, Estela Paz-Artal, Yehuda Shoenfeld, Antonio Serrano
BACKGROUND: Early detection of antinuclear antibodies (ANA) in asymptomatic subjects is useful to predict autoimmune diseases years before diagnosis. ANA have been determined by indirect immunofluorescence (IIF) using human epithelial type 2 (HEp-2) cells, which is considered the gold standard technique. Multiplex technology (BioPlex ANA Screen) has been introduced for ANA evaluation in recent years. Nevertheless, concordance between BioPlex and IIF is low and there is no harmonization between both methods for detection of autoantibodies...
June 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28628474/prediction-of-human-iron-bioavailability-using-rapid-c-elisas-for-human-plasma-hepcidin
#2
Nicole U Stoffel, Christophe Zeder, Eloïse Fort, Dorine W Swinkels, Michael B Zimmermann, Diego Moretti
BACKGROUND: Hepcidin is the central systemic regulator of iron metabolism, but its quantification in biological fluids is challenging. Rapid, accurate and user-friendly methods are needed. Our aim was to assess the ability of hepcidin as measured by three different c-ELISA assays to predict iron bioavailability in humans. METHODS: The three assays used were commercially available DRG and Peninsula assays and the c-ELISA method performed at Radboud University Medical Centre, Nijmegen, The Netherlands (Hepcidinanalysis...
June 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28598795/determination-of-reference-intervals-for-urinary-steroid-profiling-using-a-newly-validated-gc-ms-ms-method
#3
Wilhelmina H A de Jong, Edward Buitenwerf, Alle T Pranger, Ineke J Riphagen, Bruce H R Wolffenbuttel, Michiel N Kerstens, Ido P Kema
BACKGROUND: Urinary steroid profiling (USP) is a powerful diagnostic tool to asses disorders of steroidogenesis. Pre-analytical factors such as age, sex and use of oral contraceptive pills (OCP) may affect steroid hormone synthesis and metabolism. In general, USP reference intervals are not adjusted for these variables. In this study we aimed to establish such reference intervals using a newly-developed and validated gas chromatography with tandem mass spectrometry detection method (GC-MS/MS)...
June 9, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28598794/falsely-elevated-thyroid-stimulating-hormone-value-due-to-anti-ruthenium-antibodies-in-a-patient-with-primary-hypothyroidism-a-case-report
#4
LETTER
Rocío Suarez Rivero, Francisco Ponce Lorenzo, Joaquina Díaz Torres, José Manuel Ruiz Palomar, Domingo Orozco-Beltran
No abstract text is available yet for this article.
June 9, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28590915/cancer-sniffer-dogs-how-can-we-translate-this-peculiarity-in-laboratory-medicine-results-of-a-pilot-study-on-gastrointestinal-cancers
#5
Concetta Panebianco, Edgar Kelman, Kristel Vene, Domenica Gioffreda, Francesca Tavano, Raivo Vilu, Fulvia Terracciano, Illar Pata, Kaarel Adamberg, Angelo Andriulli, Valerio Pazienza
BACKGROUND: Identification of cancer biomarkers to allow early diagnosis is an urgent need for many types of tumors, whose prognosis strongly depends on the stage of the disease. Canine olfactory testing for detecting cancer is an emerging field of investigation. As an alternative, here we propose to use GC-Olfactometry (GC/O), which enables the speeding up of targeted biomarker identification and analysis. A pilot study was conducted in order to determine odor-active compounds in urine that discriminate patients with gastrointestinal cancers from control samples (healthy people)...
June 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28586301/definition-of-the-upper-reference-limit-of-glycated-albumin-in-blood-donors-from-italy
#6
Chiara Bellia, Martina Zaninotto, Chiara Cosma, Luisa Agnello, Bruna Lo Sasso, Giulia Bivona, Mario Plebani, Marcello Ciaccio
BACKGROUND: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. METHODS: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany)...
June 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28586300/assessment-of-the-clinical-utility-of-adding-common-single-nucleotide-polymorphism-genetic-scores-to-classical-risk-factor-algorithms-in-coronary-heart-disease-risk-prediction-in-uk-men
#7
Katherine E Beaney, Jackie A Cooper, Fotios Drenos, Steve E Humphries
BACKGROUND: Risk prediction algorithms for coronary heart disease (CHD) are recommended for clinical use. However, their predictive ability remains modest and the inclusion of genetic risk may improve their performance. METHODS: QRISK2 was used to assess CHD risk using conventional risk factors (CRFs). The performance of a 19 single nucleotide polymorphism (SNP) gene score (GS) for CHD including variants identified by genome-wide association study and candidate gene studies (weighted using the results from the CARDIoGRAMplusC4D meta-analysis) was assessed using the second Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284 cases)...
June 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593911/the-challenges-of-genetic-risk-scores-for-the-prediction-of-coronary-heart-disease
#8
EDITORIAL
Daniela Börnigen, Mahir Karakas, Tanja Zeller
No abstract text is available yet for this article.
June 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593910/the-eflm-strategy-for-harmonization-of-the-preanalytical-phase
#9
REVIEW
Giuseppe Lippi, Ana-Maria Simundic
The Working Group for the Preanalytical Phase (WG-PRE) was officially established by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) in 2013, with the aim of improving harmonization in the preanalytical phase across European member societies. Since its early birth, the WG-PRE has already completed a number of projects, including harmonizing the definition of fasting status, patient and blood tubes identification, color coding of blood collection tubes, sequence of tubes during blood drawing and participation in the development of suitable preanalytical quality indicators...
June 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593909/distinction-between-urine-crystals-by-automated-urine-analyzer-sedimax-contrust-is-specific-but-lacks-sensitivity
#10
LETTER
Vincent Castiglione, Etienne Cavalier, Coumba Diop, Romy Gadisseur
No abstract text is available yet for this article.
June 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593916/preparation-calibration-and-evaluation-of-the-first-international-standard-for-human-c-peptide
#11
Melanie Moore, Thomas Dougall, Jackie Ferguson, Peter Rigsby, Chris Burns
BACKGROUND: Measurement of C-peptide by immunoassay contributes to the diagnosis of a number of disorders related to β cell function. Stocks of the current international reference reagent (IRR) for C-peptide, used to calibrate these immunoassays, are exhausted, and this report summarises the international study to establish a replacement World Health Organization (WHO) international standard (IS) to maintain the availability of a globally available reference material and support efforts to standardise C-peptide assays...
May 24, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28493816/sample-types-applied-for-molecular-diagnosis-of-therapeutic-management-of-advanced-non-small-cell-lung-cancer-in-the-precision-medicine
#12
Yanxi Han, Jinming Li
In this era of precision medicine, molecular biology is becoming increasingly significant for the diagnosis and therapeutic management of non-small cell lung cancer. The specimen as the primary element of the whole testing flow is particularly important for maintaining the accuracy of gene alteration testing. Presently, the main sample types applied in routine diagnosis are tissue and cytology biopsies. Liquid biopsies are considered as the most promising alternatives when tissue and cytology samples are not available...
May 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593906/biomarkers-of-acute-kidney-injury-a-step-forward
#13
EDITORIAL
Mario Plebani
No abstract text is available yet for this article.
May 9, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593877/advanced-lipoprotein-testing-for-cardiovascular-diseases-risk-assessment-a-review-of-the-novel-approaches-in-lipoprotein-profiling
#14
REVIEW
Noémie Clouet-Foraison, Francois Gaie-Levrel, Philippe Gillery, Vincent Delatour
With the increasing prevalence of cardiovascular diseases (CVD) worldwide, finding reliable and clinically relevant biomarkers to predict acute cardiovascular events has been a major aim of the scientific and medical community. Improvements of the understanding of the pathophysiological pathways of the disease highlighted the major role of lipoprotein particles, and these past decades have seen the emergence of a number of new methodologies to separate, measure and quantitate lipoproteins. Those methods, also known as advanced lipoprotein testing methods (ALT), have gained acceptance in the field of CVD risk assessment and have proven their clinical relevance...
May 8, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593929/high-titers-of-anti-infliximab-antibody-do-not-interfere-with-abbott-immunoassays
#15
LETTER
Il Jo, Balázs Szalay, Zsuzsanna Végh, Zsuzsanna Kürti, Ferenc Olajos, Barna Vásárhelyi
No abstract text is available yet for this article.
May 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593928/a-survey-of-patients-views-from-eight-european-countries-of-interpretive-support-from-specialists-in-laboratory-medicine
#16
Ian D Watson, Wytze P Oosterhuis, Per E Jorgensen, Z Gunnur Dikmen, Joanna Siodmiak, Snezana Jovicic, Kristin M Aakre, Vladimir Palicka, Marge Kutt
BACKGROUND: There is increasing interest in direct patient engagement including receiving their laboratory medicine results. We previously established an appetite for Specialists in Laboratory Medicine to support patients in understanding results. The aim of this study was to establish whether patients agreed with such an approach, determined through surveying views in eight European countries. METHODS: A standardized five-question survey was administered across eight European countries to a total of 1084 individuals attending medical outpatient clinics, with 100 patients each in Poland, Serbia, Netherlands, Turkey and Czech Republic, 101 in Estonia, 116 in Denmark and 367 in Norway...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593927/laboratory-characterization-of-leukemic-cell-procoagulants
#17
Renáta Hudák, Ildikó Beke Debreceni, Ivett Deák, Gabriella Gál Szabó, Zsuzsanna Hevessy, Péter Antal-Szalmás, Bjarne Osterud, János Kappelmayer
BACKGROUND: In acute myeloid leukemias, there is an increased chance to develop thrombotic disorders. We hypothesized that in addition to leukemic promyelocytes, monocytic leukemia cells may also have a higher procoagulant activity. METHODS: Fibrin formation was assessed by a one-stage clotting assay using a magnetic coagulometer. The thrombin generation test (TGT) of magnetically isolated normal human monocytes, intact leukemic cells and their isolated microparticles was performed by a fluorimetric assay...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593926/the-impact-of-pneumatic-tube-system-on-routine-laboratory-parameters-a-systematic-review-and-meta-analysis
#18
REVIEW
Georgia V Kapoula, Panagiota I Kontou, Pantelis G Bagos
BACKGROUND: Pneumatic tube system (PTS) is a widely used method of transporting blood samples in hospitals. The aim of this study was to evaluate the effects of the PTS transport in certain routine laboratory parameters as it has been implicated with hemolysis. METHODS: A systematic review and a meta-analysis were conducted. PubMed and Scopus databases were searched (up until November 2016) to identify prospective studies evaluating the impact of PTS transport in hematological, biochemical and coagulation measurements...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593925/intensive-educational-efforts-combined-with-external-quality-assessment-improve-the-preanalytical-phase-in-general-practitioner-offices-and-nursing-homes
#19
Una Ørvim Sølvik, Wenche Iren Bjelkarøy, Kari van den Berg, Anne Lise Saga, Helle Borgstrøm Hager, Sverre Sandberg
BACKGROUND: Errors in the preanalytical phase in clinical laboratories affect patient safety. The aim of this study was to evaluate the effect of intensive educational efforts together with external quality assessment (EQA) of the preanalytical phase from 2013 to 2015 to improve patient identification in primary health care in Norway. In addition, routines for venous and capillary blood sampling were investigated. METHODS: A preanalytical EQA was circulated in 2013 by the Norwegian Quality Improvement of Laboratory Examinations (Noklus) to general practitioner offices and nursing homes (n=2000) to obtain information about important issues to focus on before launching an intensive educational program with courses, posters and visits in 2013-2015...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28593924/influence-of-age-gender-and-body-mass-index-on-late-night-salivary-cortisol-in-healthy-adults
#20
Sabrina Coelli, Camila Bergonsi Farias, Ariana Aguiar Soares, Gabriele Martins Crescente, Vânia Naomi Hirakata, Luiza Barboza Souza, Mauro Antônio Czepielewski, Joíza Lins Camargo, Sandra Pinho Silveiro
BACKGROUND: Late-night salivary cortisol (LNSC) is one of the most reliable tests to screen for endogenous Cushing syndrome. This test is simple, inexpensive and noninvasive and has high sensitivity and specificity. The aim of our study was to analyze the putative influence of age, gender and body mass index (BMI) on LNSC levels in a healthy population. METHODS: Cross-sectional study conducted in healthy adults. Midnight saliva samples were collected at home. Participants refrained from teeth brushing, eating or drinking for 2 h prior to collection...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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