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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/28796640/reporting-ldl-cholesterol-levels-in-the-era-of-intensive-lipid-management-a-clarion-call
#1
EDITORIAL
Ishwarlal Jialal, Verena Gounden
No abstract text is available yet for this article.
August 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28796639/development-and-validation-of-a-multivariable-prediction-rule-for-detecting-a-severe-acquired-adamts13-activity-deficiency-in-patients-with-thrombotic-microangiopathies
#2
Jorge M Nieto, Félix De La Fuente-Gonzalo, Fernando A González, Ana Villegas, Rafael Martínez, Manuel E Fuentes, Paloma Ropero
BACKGROUND: Thrombotic microangiopathies (TMAs) are a group of diseases that have different aetiologies and treatments, but a clinical differential diagnosis remains difficult. Among TMAs, thrombotic thrombocytopenic purpura (TTP) is characterised by a severe ADAMTS13 functional deficiency. However, assays exploring ADAMTS13 activity are limited to some specialised laboratories. Our objective was to develop and validate a diagnostic method for TTP in adult patients with TMA. METHODS: We generated a multivariable model (four predictors) on a cohort of 174 TMA patients in order to predict an ADAMTS13 activity deficiency (AUC of 0...
August 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28796638/quantification-of-1-25-dihydroxyvitamin-d-value-of-manufacturers-product-information
#3
LETTER
Michael Vogeser, Martin Bidlingmaier, Henri Wallaschowski, Johanna Lindner, Jürgen Kratzsch
No abstract text is available yet for this article.
August 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28796637/the-use-of-error-and-uncertainty-methods-in-the-medical-laboratory
#4
Wytze P Oosterhuis, Hassan Bayat, David Armbruster, Abdurrahman Coskun, Kathleen P Freeman, Anders Kallner, David Koch, Finlay Mackenzie, Gabriel Migliarino, Matthias Orth, Sverre Sandberg, Marit S Sylte, Sten Westgard, Elvar Theodorsson
Error methods - compared with uncertainty methods - offer simpler, more intuitive and practical procedures for calculating measurement uncertainty and conducting quality assurance in laboratory medicine. However, uncertainty methods are preferred in other fields of science as reflected by the guide to the expression of uncertainty in measurement. When laboratory results are used for supporting medical diagnoses, the total uncertainty consists only partially of analytical variation. Biological variation, pre- and postanalytical variation all need to be included...
August 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28787269/a-comparison-between-high-resolution-serum-protein-electrophoresis-and-screening-immunofixation-for-the-detection-of-monoclonal-gammopathies-in-serum
#5
Joel Smith, Geoffrey Raines, Hans-Gerhard Schneider
BACKGROUND: There are a variety of initial laboratory tests or combinations of tests that can be performed when a monoclonal gammopathy is suspected including serum protein electrophoresis (SPEP), urine protein electrophoresis (UPEP), serum immunofixation (IFE) and serum free light chain assays. Some groups have recently used simplified "screening" IFE methods for the detection of monoclonal gammopathies leveraging the greater sensitivity of IFE over SPEP alone to improve the detection of monoclonal gammopathies...
August 8, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28787268/the-seemore-strategy-single-tube-electrophoresis-analysis-based-genotyping-to-detect-monogenic-diseases-rapidly-and-effectively-from-conception-until-birth
#6
Federica Cariati, Maria Savarese, Valeria D'Argenio, Francesco Salvatore, Rossella Tomaiuolo
BACKGROUND: The development of technologies that detect monogenic diseases in embryonic and fetal samples are opening novel diagnostic possibilities for preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) thereby changing laboratory practice. Molecular diagnostic laboratories use different workflows for PND depending on the disease, type of biological sample, the presence of one or more known mutations, and the availability of the proband. Paternity verification and contamination analysis are also performed...
August 8, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28787267/predicting-outcomes-of-egfr-targeted-therapy-in-non-small-cell-lung-cancer-patients-using-pleural-effusions-samples-and-peptide-nucleic-acid-probe-assay
#7
Mei-Chia Wang, Chih-Liang Wang, Tai-Long Chen, John Wen-Cheng Chang, Jang-Jih Lu, Pi-Yueh Chang, Chiuan-Chian Chiou
BACKGROUND: Mutation of epidermal growth factor receptor (EGFR) is a prediction marker of the response to tyrosine kinase inhibitor (TKI) drugs in non-small cell lung cancer (NSCLC) patients. As late stage lung cancer patients rarely undergo surgery, samples for EGFR mutation identification usually come from computed tomography (CT)-guided or endoscopic biopsies, which is invasive and costly. Pleural effusion may serve as a less invasive sample for EGFR mutation detection. METHODS: We designed a fluorophore-labeled peptide nucleic acid (PNA) probe assay for three types of EGFR mutations, including exon 19 deletions, L858R point mutations and T790M point mutations...
August 8, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28771431/in-vivo-interference-of-ioversol-in-serum-and-urine-capillary-electrophoresis-an-optimized-protocol-for-sample-collection
#8
LETTER
Covadonga Quirós, Ana Isabel Cillero, Laura Bretaña, María García, Belén Prieto, Francisco V Álvarez
No abstract text is available yet for this article.
August 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28771430/evaluation-of-a-new-free-light-chain-elisa-assay-bringing-coherence-with-electrophoretic-methods
#9
Joannes F M Jacobs, Corrie M de Kat Angelino, Huberdina M L M Brouwers, Sandra A Croockewit, Irma Joosten, Renate G van der Molen
BACKGROUND: Serum free light chain (sFLC) measurements are increasingly important in the context of screening for monoclonal gammopathies, prognostic stratification, and monitoring of therapy responses. At the same time, analytical limitations have been reported with the currently available nephelometric and turbidimetric sFLC assays. We have evaluated a new quantitative sFLC ELISA for its suitability in routine clinical use. METHODS: Reference ranges of the Sebia FLC assay were calculated from 208 controls...
August 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28771429/the-key-incident-monitoring-and-management-system-history-and-role-in-quality-improvement
#10
Tony Badrick, Stephanie Gay, Mark Mackay, Ken Sikaris
BACKGROUND: The determination of reliable, practical Quality Indicators (QIs) from presentation of the patient with a pathology request form through to the clinician receiving the report (the Total Testing Process or TTP) is a key step in identifying areas where improvement is necessary in laboratories. METHODS: The Australasian QIs programme Key Incident Monitoring and Management System (KIMMS) began in 2008. It records incidents (process defects) and episodes (occasions at which incidents may occur) to calculate incident rates...
August 3, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763299/false-negative-results-caused-by-erroneous-automated-result-interpretation-algorithm-on-the-filmarray-2-0-instrument
#11
LETTER
Chun Kiat Lee, Lily Chiu, Gabriel Yan, Ka Lip Chew, Benedict Yan, Roland Jureen, Tze Ping Loh
No abstract text is available yet for this article.
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763298/interference-between-ethosuximide-and-barbiturates-in-an-immunochromatographic-method
#12
LETTER
Paula San-José, Ruth Cano-Corres, Vicente Aguadero, Paula Miralles-Albors, Eugenio Berlanga-Escalera
No abstract text is available yet for this article.
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763297/adiponectin-and-leptin-as-first-trimester-markers-for-gestational-diabetes-mellitus-a-cohort-study
#13
Ida Näslund Thagaard, Lone Krebs, Jens-Christian Holm, Theis Lange, Torben Larsen, Michael Christiansen
BACKGROUND: Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester. METHODS: A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese...
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763296/hair-testing-of-ghb-an-everlasting-issue-in-forensic-toxicology
#14
REVIEW
Francesco Paolo Busardò, Simona Pichini, Simona Zaami, Roberta Pacifici, Pascal Kintz
BACKGROUND: In this paper, the authors present a critical review of different studies regarding hair testing of endogenous γ-hydroxybutyrate (GHB), concentrations in chronic users, and values measured after a single GHB exposure in drug facilitated sexual assault (DFSA) cases together with the role of a recently identified GHB metabolite, GHB-glucuronide. CONTENT: The following databases (up to March 2017) PubMed, Scopus and Web of Science were used, searching the following key words: γ-hydroxybutyrate, GHB, GHB glucuronide, hair...
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763295/contamination-of-dried-blood-spots-an-underestimated-risk-in-newborn-screening
#15
Theresa Winter, Anja Lange, Anke Hannemann, Matthias Nauck, Cornelia Müller
BACKGROUND: Newborn screening (NBS) is an established screening procedure in many countries worldwide, aiming at the early detection of inborn errors of metabolism. For decades, dried blood spots have been the standard specimen for NBS. The procedure of blood collection is well described and standardized and includes many critical pre-analytical steps. We examined the impact of contamination of some anticipated common substances on NBS results obtained from dry spot samples. This possible pre-analytical source of uncertainty has been poorly examined in the past...
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28763294/prevalence-and-causes-of-abnormal-psa-recovery
#16
Noémie Lautenbach, Michael Müntener, Paolo Zanoni, Lanja Saleh, Karim Saba, Martin Umbehr, Srividya Velagapudi, Danielle Hof, Tullio Sulser, Peter J Wild, Arnold von Eckardstein, Cédric Poyet
BACKGROUND: Prostate-specific antigen (PSA) test is of paramount importance as a diagnostic tool for the detection and monitoring of patients with prostate cancer. In the presence of interfering factors such as heterophilic antibodies or anti-PSA antibodies the PSA test can yield significantly falsified results. The prevalence of these factors is unknown. METHODS: We determined the recovery of PSA concentrations diluting patient samples with a standard serum of known PSA concentration...
August 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28755530/individual-values-of-antineutrophil-cytoplasmic-antibodies-do-not-correspond-between-antigen-specific-assays
#17
LETTER
Niels Rasmussen, Jan Damoiseaux, Elena Csernok, Niels H H Heegaard, Bernhard Hellmich, Pieter van Paassen, Bo Baslund, Pieter Vermeersch, Daniel Blockmans, Jan-Willem Cohen Tervaert, Xavier Bossuyt
No abstract text is available yet for this article.
July 29, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28755529/pr3-anti-neutrophil-cytoplasmic-antibodies-anca-in-ulcerative-colitis
#18
LETTER
Michael Mahler, Jan Damoiseaux, Vera Ballet, Doreen Dillaerts, Chelsea Bentow, Jan-Willem Cohen Tervaert, Daniel Blockmans, Guy Boeckxstaens, Javier Aguilera-Lizarraga, Elena Csernok, Severine Vermeire, Xavier Bossuyt
No abstract text is available yet for this article.
July 29, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28753535/the-risk-of-unjustified-brca-testing-after-the-angelina-jolie-effect-how-can-we-save-laboratory-medicine-from-the-internet
#19
LETTER
Giuseppe Lippi
No abstract text is available yet for this article.
July 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28753534/liquid-biopsy-in-ovarian-cancer-recent-advances-on-circulating-tumor-cells-and-circulating-tumor-dna
#20
Lydia Giannopoulou, Sabine Kasimir-Bauer, Evi S Lianidou
Ovarian cancer remains the most lethal disease among gynecological malignancies despite the plethora of research studies during the last decades. The majority of patients are diagnosed in an advanced stage and exhibit resistance to standard chemotherapy. Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) represent the main liquid biopsy approaches that offer a minimally invasive sample collection. Both have shown a diagnostic, prognostic and predictive value in many types of solid malignancies and recent studies attempted to shed light on their role in ovarian cancer...
July 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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