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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/30004902/joint-eflm-colabiocli-recommendation-for-venous-blood-sampling
#1
REVIEW
Ana-Maria Simundic, Karin Bölenius, Janne Cadamuro, Stephen Church, Michael P Cornes, Edmée C van Dongen-Lases, Pinar Eker, Tanja Erdeljanovic, Kjell Grankvist, Joao Tiago Guimaraes, Roger Hoke, Mercedes Ibarz, Helene Ivanov, Svetlana Kovalevskaya, Gunn B B Kristensen, Gabriel Lima-Oliveira, Giuseppe Lippi, Alexander von Meyer, Mads Nybo, Barbara De la Salle, Christa Seipelt, Zorica Sumarac, Pieter Vermeersch
This document provides a joint recommendation for venous blood sampling of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for Preanalytical Phase (WG-PRE) and Latin American Working Group for Preanalytical Phase (WG-PRE-LATAM) of the Latin America Confederation of Clinical Biochemistry (COLABIOCLI). It offers guidance on the requirements for ensuring that blood collection is a safe and patient-centered procedure and provides practical guidance on how to successfully overcome potential barriers and obstacles to its widespread implementation...
July 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30004901/estimated-gfr-specific-99th-percentiles-for-high-sensitive-cardiac-troponin-t-based-on-the-adjusted-analytical-change-limit-adjacl-in-hospitalized-patients
#2
LETTER
Denis Monneret, Pierre Hausfater, Bruno Riou, Dominique Bonnefont-Rousselot
No abstract text is available yet for this article.
July 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30004900/effects-of-high-dose-intravenous-lipid-emulsion-on-laboratory-tests-in-humans-a-randomized-placebo-controlled-double-blind-clinical-crossover-trial
#3
Kasper M Petersen, Niklas R Jørgensen, Søren Bøgevig, Tonny S Petersen, Thomas B Jensen, Kim P Dalhoff, Mikkel B Christensen
Background Intravenous lipid emulsion (ILE) is used to treat drug poisonings. The resultant hyperlipemia may affect laboratory tests but the consequences are poorly characterized. In a clinical trial we therefore investigated the effects of ILE on laboratory tests analyzed on common analytical platforms (Roche® cobas 8000 and SYSMEX® flow-cytometry). Methods Ten healthy participants each completed 4 trial days (two with ILE and two with placebo). ILE (5.25 mL/kg) was administered from 12.5 to 30 min from baseline...
July 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29995630/clinical-chemistry-and-laboratory-medicine-continues-to-shine-brightly-in-the-constellation-of-laboratory-medicine
#4
EDITORIAL
Mario Plebani, Giuseppe Lippi
No abstract text is available yet for this article.
July 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29995629/detection-capability-of-quantitative-faecal-immunochemical-tests-for-haemoglobin-fit-and-reporting-of-low-faecal-haemoglobin-concentrations
#5
Callum G Fraser, Sally C Benton
Faecal immunochemical tests for haemoglobin (FIT) are widely used in asymptomatic population screening for colorectal (bowel) cancer. FIT are also used to assist with the assessment of patients presenting with lower abdominal symptoms. Quantitative FIT allow the generation of numerical estimates of faecal haemoglobin (f-Hb) concentrations. There is now great interest in "low" f-Hb concentrations in these clinical settings: in consequence, knowledge of the detection capability is very important for f-Hb concentration examinations...
July 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29990305/undetected-paraganglioma-by-functional-imaging-techniques-case-report
#6
LETTER
Ruth Cano-Corres, Gemma Sole-Enrech, Marta Solà-García, Eugenio Berlanga-Escalera
No abstract text is available yet for this article.
July 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29990304/personalized-laboratory-medicine-a-patient-centered-future-approach
#7
REVIEW
Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, Csilla Sipeky, Ron van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc
In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management...
July 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29990303/assessment-of-architect-csystems-abbott%C3%A2-for-the-colorimetric-measurement-of-lithium-in-urines-and-dyalisates
#8
Carole Hennequin, Tsandni Jamal, Annie Leyris, Jean-Louis Beaudeux, Pascal Houzé
No abstract text is available yet for this article.
July 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29982235/harmonization-in-laboratory-medicine-blowin-in-the-wind
#9
EDITORIAL
Mario Plebani, Maria Stella Graziani, Jillian R Tate
No abstract text is available yet for this article.
July 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29959885/a-peculiar-reaction-curve-with-dual-spikes-in-absorbance-during-a-total-bilirubin-assay-in-spite-of-accurate-results-induced-by-high-m-protein-concentration
#10
LETTER
Kaustubh Bora, Happy Chutia
No abstract text is available yet for this article.
June 30, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29949508/uncertainty-in-measurement-and-total-error-different-roads-to-the-same-quality-destination
#11
Ian Farrance, Tony Badrick, Robert Frenkel
The debate comparing the benefits of measurement uncertainty (uncertainty in measurement, MU) with total error (TE) for the assessment of laboratory performance continues. The summary recently provided in this journal by members of the Task and Finish Group on Total Error (TFG-TE) of the EFLM put the arguments into clear perspective. Even though there is generally strong support for TE in many laboratories, some of the arguments proposed for its on-going support require further comment. In a recent opinion which focused directly on the TFG-TE summary, several potentially confusing statements regarding ISO15189 and the Evaluation of measurement data - Guide to the expression of uncertainty in measurement (GUM) were again promulgated to promote TE methods for assessing uncertainty in laboratory measurement...
June 27, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29949507/commutability-of-the-certified-reference-materials-for-the-standardization-of-%C3%AE-amyloid-1-42-assay-in-human-cerebrospinal-fluid-lessons-for-tau-and-%C3%AE-amyloid-1-40-measurements
#12
Ulf Andreasson, Julia Kuhlmann, Josef Pannee, Robert M Umek, Erik Stoops, Hugo Vanderstichele, Anja Matzen, Manu Vandijck, Martine Dauwe, Andreas Leinenbach, Sandra Rutz, Erik Portelius, Ingrid Zegers, Henrik Zetterberg, Kaj Blennow
BACKGROUND: The core Alzheimer's disease cerebrospinal fluid (CSF) biomarkers total tau (T-tau), phosphorylated tau (P-tau), β-amyloid 1-42 (Aβ42) and β-amyloid 1-40 (Aβ40) are increasing in importance and are now part of the research criteria for the diagnosis of the disease. The main aim of this study is to evaluate whether a set of certified reference materials (CRMs) are commutable for Aβ42 and to serve as a feasibility study for the other markers. This property is a prerequisite for the establishment of CRMs which will then be used by manufacturers to calibrate their assays against...
June 27, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29949506/increased-serum-concentrations-of-soluble-st2-predict-mortality-after-burn-injury
#13
Stefan Hacker, Benjamin Dieplinger, Gregor Werba, Stefanie Nickl, Georg A Roth, Claus G Krenn, Thomas Mueller, Hendrik J Ankersmit, Thomas Haider
BACKGROUND: Large burn injuries induce a systemic response in affected patients. Soluble ST2 (sST2) acts as a decoy receptor for interleukin-33 (IL-33) and has immunosuppressive effects. sST2 has been described previously as a prognostic serum marker. Our aim was to evaluate serum concentrations of sST2 and IL-33 after thermal injury and elucidate whether sST2 is associated with mortality in these patients. METHODS: We included 32 burn patients (total body surface area [TBSA] >10%) admitted to our burn intensive care unit and compared them to eight healthy probands...
June 27, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29935113/impact-of-blood-cell-counts-and-volumes-on-glucose-concentration-in-uncentrifuged-serum-and-lithium-heparin-blood-tubes
#14
Giuseppe Lippi, Gian Luca Salvagno, Simona Lampus, Elisa Danese, Matteo Gelati, Chiara Bovo, Martina Montagnana, Ana-Maria Simundic
BACKGROUND: Although it is known that glucose concentration exhibits a time-dependent decay in uncentrifuged serum and lithium-heparin blood tubes, no evidence exists on how this variation may depend on blood cell counts (CBC) and volumes. METHODS: Venous blood was drawn from 30 non fasting healthy volunteers into three serum and three lithium-heparin tubes. One serum and lithium-heparin tubes were centrifuged within 15 min after collection and glucose was measured with a hexokinase assay...
June 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29935112/nephelometric-assay-of-urine-free-light-chains-an-alternative-and-early-clinical-test-for-bence-jones-protein-quantification
#15
LETTER
Massimo Pieri, Stefano Pignalosa, Luca Franceschini, Manuela Rizzo, Maria Cantonetti, Rossella Zenobi, Sergio Bernardini, Mariarita Dessi
No abstract text is available yet for this article.
June 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29935111/reference-ranges-of-the-sebia-free-light-chain-ratio-in-patients-with-chronic-kidney-disease
#16
LETTER
Laurence Lutteri, Joannes F M Jacobs
No abstract text is available yet for this article.
June 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29935110/harmonization-of-microbiology-processes-and-standards-work-in-progress
#17
Linoj P Samuel
Clinical microbiology is a highly challenging technical discipline, which makes it difficult to harmonize processes and protocols. In addition, the lack of scientific consensus on some diagnostic algorithms and the need to address the diverse needs of different patient populations contribute to the lack of interlaboratory consistency. Laboratories utilize a number of measures and metrics, but the lack of standardized approaches and data collection means that they cannot effectively evaluate their performance against their peers...
June 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29927745/history-of-disruptions-in-laboratory-medicine-what-have-we-learned-from-predictions
#18
REVIEW
Larry J Kricka
Predictions about the future of laboratory medicine have had a mixed success, and in some instances they have been overambitious and incorrectly assessed the future impact of emerging technologies. Current predictions suggest a more highly automated and connected future for diagnostic testing. The central laboratory of the future may be dominated by more robotics and more connectivity in order to take advantage of the benefits of the Internet of Things and artificial intelligence (AI)-based systems (e.g. decision support software and imaging analytics)...
June 21, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29927744/analytical-validation-of-two-second-generation-thyroglobulin-immunoassays-roche-and-thermo-fisher
#19
LETTER
François-Marie Moussallieh, Miora Koloina Ranaivosoa, Sarah Romain, Nathalie Reix
No abstract text is available yet for this article.
June 21, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29924735/comparison-of-three-staining-methods-in-the-automated-digital-cell-imaging-analyzer-sysmex-di-60
#20
LETTER
Hyeong Nyeon Kim, Mina Hur, Hanah Kim, Mikyoung Park, Seung Wan Kim, Hee-Won Moon, Yeo-Min Yun
No abstract text is available yet for this article.
June 20, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
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