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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/30427777/effect-of-an-activated-charcoal-product-doac-stop%C3%A2-intended-for-extracting-doacs-on-various-other-aptt-prolonging-anticoagulants
#1
Thomas Exner, Monica Ahuja, Lisa Ellwood
Background The aim of the study was to investigate the specificity of an activated charcoal-based product (DOAC Stop™) initially intended for the specific extraction of direct oral anticoagulants (DOACs) from test plasmas on a range of other anticoagulants. Methods Test plasmas were prepared by adding various anticoagulants to pooled normal plasma at concentrations prolonging an activated partial thromboplastin time (APTT) test by a factor of 1.5-3. These plasmas were treated with DOAC Stop™ for 5 and 20 min...
November 14, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30427776/central-adrenal-insufficiency-open-issues-regarding-diagnosis-and-glucocorticoid-treatment
#2
REVIEW
Filippo Ceccato, Carla Scaroni
Background Central adrenal insufficiency (CAI) is characterized by impaired adrenocorticotropin (ACTH) secretion because of a disease or injury to the hypothalamus or the pituitary, leading to a reduced cortisol production. CAI suspicion arises more frequently in patients with pituitary tumors, cranial irradiation/surgery/injury/infections, as well as after exogenous glucocorticoid withdrawal. Nevertheless, a late diagnosis is not uncommon because CAI may present with nonspecific signs or symptoms, as fatigue or hyponatremia...
November 14, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30422797/extracellular-vesicle-associated-mirnas-in-ovarian-cancer-design-of-an-integrated-ngs-based-workflow-for-the-identification-of-blood-based-biomarkers-for-platinum-resistance
#3
Jan Dominik Kuhlmann, Issam Chebouti, Rainer Kimmig, Paul Buderath, Michael Reuter, Sven-Holger Puppel, Pauline Wimberger, Sabine Kasimir-Bauer
Background Extracellular vesicle (EV)-associated microRNAs (miRNAs) have been suggested as promising biomarkers for blood-based cancer diagnosis. However, one of the major limitations for the use of EVs with diagnostic purpose is the lack of standardized EV-profiling techniques. In this regard, the objective of our study was to design an integrated next-generation sequencing (NGS)-based workflow for analyzing the signature of EV-associated miRNA in the plasma of platinum-resistant ovarian cancer patients. Methods For EV-extraction, different enrichment methods were compared (ExoQuick vs...
November 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30422796/an-unexpectedly-prolonged-severe-hyperbilirubinemia-in-a-patient-with-pre-existing-hepatitis-a-a-role-of-genetic-predisposition
#4
LETTER
Felicia Stefania Falvella, Elena Angeli, Laura Cordier, Emilio Clementi, Mauro Panteghini
No abstract text is available yet for this article.
November 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30412464/anti-citrullinated-protein-antibodies-are-not-associated-with-extent-of-disease-or-prognosis-in-patients-with-coronary-artery-disease
#5
LETTER
Katharina Diouf, Laura Elsner, Melanie Rohr, Jan S Wolter, Oliver Dörr, Christian W Hamm, Christoph Liebetrau, Till Keller
No abstract text is available yet for this article.
November 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30412463/development-of-the-point-of-care-key-evidence-tool-pocket-a-checklist-for-multi-dimensional-evidence-generation-in-point-of-care-tests
#6
Jeremy R Huddy, Melody Ni, Shivani Misra, Stella Mavroveli, James Barlow, George B Hanna
Background This study aimed to develop the Point-of-Care Key Evidence Tool (POCKET); a multi-dimensional checklist to guide the evaluation of point-of-care tests (POCTs) incorporating validity, utility, usability, cost-effectiveness and patient experience. The motivation for this was to improve the efficiency of evidence generation in POCTs and reduce the lead-time for the adoption of novel POCTs. Methods A mixed qualitative and quantitative approach was applied. Following a literature search, a three round Delphi process was undertaken incorporating a semi-structured interview study and two questionnaire rounds...
November 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30412462/free-papp-a-as-a-biomarker-heparin-induced-release-is-not-related-to-coronary-atherosclerotic-burden
#7
Emilia Tuunainen, Teemu Maaniitty, Juhani Knuuti, Kim Pettersson, Saara Wittfooth, Antti Saraste
No abstract text is available yet for this article.
November 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30412461/evaluation-of-analytical-performances-using-standardized-analytical-protocols-and-comparison-of-clinical-results-of-the-new-advia-bnp-and-nt-probnp-immunoassays-for-the-centaur-xpt-platform
#8
Silvia Masotti, Veronica Musetti, Concetta Prontera, Simona Storti, Rudina Ndreu, Claudio Passino, Giancarlo Zucchelli, Aldo Clerico
Background The study aim was to evaluate and compare analytical performances and clinical results of ADVIA BNP and PBNP methods using the Centaur XPT platform with those of Access BNP, using the DxI platform and the ECLIA NT-proBNP method, using the Cobas e411 platform, respectively. Methods Limits of blank (LoB), detection (LoD) and quantitation (LoQ) at 20% CV and 10% CV were evaluated according to international standardized protocols. The analytical parameters were assessed throughout a 90-working-day period using three curve calibrations...
November 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30407910/communicating-laboratory-results-to-patients-and-families
#9
Holly O Witteman, Brian J Zikmund-Fisher
People are increasingly able to access their laboratory results via patient portals. The potential benefits provided by such access, such as reductions in patient burden and improvements in patient satisfaction, disease management, and medical decision making, also come with potentially valid concerns about such results causing confusion or anxiety among patients. However, it is possible to clearly convey the meaning of results and, when needed, indicate required action by designing systems to present laboratory results adapted to the people who will use them...
November 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30375345/absorbent-materials-to-collect-urine-can-affect-proteomics-and-metabolomic-biomarker-concentrations
#10
LETTER
Louis Boohaker, Brian Halloran, Landon Wilson, Taylor Berryhill, Stephen Barnes, Russell Griffin, David Askenazi
No abstract text is available yet for this article.
October 31, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30375344/a-challenging-case-highly-variable-tsh-in-a-mother-and-her-two-children
#11
LETTER
Sandrine Donadio-Andrei, Nathalie Hubert, Véronique Raverot, Emmanuelle Plantin-Carrenard, Elisabetta Kuczewski, Anne Charrié, Catherine Ronin, Anne-Sophie Gauchez, Karim Chikh
No abstract text is available yet for this article.
October 31, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30375343/the-view-of-a-general-practitioner-on-immediate-access-for-patients-to-their-laboratory-test-results
#12
Syed Ghulam Sarwar Shah, Amir Hannan, Bruce Elliott, Ingrid Brindle, Richard Fitton
This position paper presents the role of laboratory test results in traditional general practice and provides a recommendation for responsible sharing of results with patients for improved safety, efficiency and outcomes. This paper looks at the relationship between the laboratory, the general practitioner consultation, the patient, safety and general practice capacity. We suggest changes in the traditional practice of communicating laboratory test results whereby normal or abnormal results are made available to patients as soon as they become available...
October 31, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30375342/evaluation-of-reference-intervals-of-haematological-and-biochemical-markers-in-an-austrian-adolescent-study-cohort
#13
Barbara Bogner, Karin Schwenoha, Michael Vogl, Daniel Weghuber, Caroline Roth, Ulrike Kipman, Janne Cadamuro, Gertie J Oostingh
Background Reference intervals are a prerequisite for the interpretation of laboratory data related to diagnostic issues and treatment strategies. In adolescents, biomarker concentrations change with age, necessitating a continuous age-related definition of the reference intervals. The purpose of this pilot study was to evaluate the reference intervals for a healthy population of adolescents in Salzburg and compare these, when possible, with age- and gender-matched published data. Methods Anthropometrical parameters and blood samples were collected from adolescents (male and female; 14-17 years) in a school setting...
October 30, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367783/indirect-determination-of-hematology-reference-intervals-in-adult-patients-on-beckman-coulter-unicell-dxh-800-and-abbott-cell-dyn-sapphire-devices
#14
Jakob Zierk, Farhad Arzideh, Rainer Haeckel, Manfred Rauh, Markus Metzler, Thomas Ganslandt, Stefan W Krause
Background Conventional establishment of reference intervals for hematological analytes is challenging due to the need to recruit healthy persons. Indirect methods address this by deriving reference intervals from clinical laboratory databases which contain large datasets of both physiological and pathological test results. Methods We used the "Reference Limit Estimator" (RLE) to establish reference intervals for common hematology analytes in adults aged 18-60 years. One hundred and ninety-five samples from 44,519 patients, measured on two different devices in a tertiary care center were analyzed...
October 26, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367788/suppressing-all-test-results-in-grossly-hemolyzed-samples-is-this-approach-appropriate-in-every-case
#15
LETTER
Dominika Szoke, Simone Caruso, Sara Pasqualetti, Elena Aloisio, Felicia Stefania Falvella, Alberto Dolci, Mauro Panteghini
No abstract text is available yet for this article.
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367787/prozone-effect-observed-for-heavy-chain-%C3%AE-in-the-serum-immunofixation-electrophoresis-of-a-patient-with-monoclonal-iga-%C3%AE-gammopathy
#16
LETTER
Dietmar Enko, Gernot Kriegshäuser
No abstract text is available yet for this article.
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367786/influence-of-temperature-of-transport-of-whole-blood-on-plasma-cu-i-mn-se-and-zn-and-mg-concentrations-in-erythrocytes
#17
LETTER
Benoit Chovelon, Josiane Arnaud
No abstract text is available yet for this article.
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367784/determining-the-cutoff-value-of-the-aptt-mixing-test-for-factor-viii-inhibitor
#18
LETTER
Ning Tang, Yaopeng Chen, Dengju Li, Shiyu Yin
No abstract text is available yet for this article.
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367782/significant-allelic-dropout-phenomenon-of-oncomine-brca-research-assay-on-ion-torrent-s5
#19
LETTER
Tae-Dong Jeong, Sung-Yup Cho, Mi-Wha Kim, Jungwon Huh
No abstract text is available yet for this article.
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30367781/adding-clinical-utility-to-the-laboratory-reports-automation-of-interpretative-comments
#20
Wytze Oosterhuis
In laboratory medicine, consultation by adding interpretative comments to reports has long been recognized as one of the activities that help to improve patient treatment outcomes and strengthen the position of our profession. Interpretation and understanding of laboratory test results might in some cases considerably be enhanced by adding test when considered appropriate by the laboratory specialist - an activity that was named reflective testing. With patient material available at this stage, this might considerably improve the diagnostic efficiency...
October 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
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