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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/29150989/an-evaluation-of-the-sentifit-270-analyser-for-quantitation-of-faecal-haemoglobin-in-the-investigation-of-patients-with-suspected-colorectal-cancer
#1
Josep M Auge, Cristina Rodriguez, Oihana Espanyol, Liseth Rivero, Silvia Sandalinas, Jaume Grau, Wladimiro Jimenez, Antoni Castells
BACKGROUND: An evaluation of SENTiFIT® 270 (Sentinel Diagnostics, Italy; Sysmex, Spain) analyser for the quantitation of faecal haemoglobin (f-Hb) was performed. METHODS: The analytical imprecision, linearity, carry over and f-Hb stability were determined. Evaluation of the diagnostic accuracy was performed on 487 patients. RESULTS: Within-run and between-run imprecision ranged 1.7%-5.1% and 3.8%-6.2%, respectively. Linearity studies revealed a mean recovery of 101...
November 18, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29140791/reply-to-hyperuricemia-does-not-seem-to-be-an-independent-risk-factor-for-coronary-heart-disease
#2
LETTER
Federica Braga, Simona Ferraro, Sara Pasqualetti, Mauro Panteghini
No abstract text is available yet for this article.
November 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29140790/antioxidant-capacity-in-patients-with-type-2-diabetes-a-preliminary-investigation-on-gender-specific-differences-in-an-italian-population
#3
LETTER
Nino Cristiano Chilelli, Chiara Cosma, Silvia Burlina, Mario Plebani, Annunziata Lapolla
No abstract text is available yet for this article.
November 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29127759/is-irisin-the-new-player-in-exercise-induced-adaptations-or-not-a-2017-update
#4
REVIEW
Ioannis G Fatouros
Irisin is produced by a proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has emerged as a potential mediator of exercise-induced energy metabolism. The purpose of this study was to review the results of studies that investigated irisin responses to acute and chronic exercise and provide an update. A comprehensive search in the databases of MEDLINE was performed (74 exercise studies). The focus of the analysis was on data concerning FNDC5 mRNA expression in skeletal muscle and circulating irisin concentration relatively to exercise mode, intensity, frequency and duration and the characteristics of the sample used...
November 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29116932/impact-of-citrated-blood-collection-tubes-on-red-cell-morphology-implications-for-the-measurement-of-plasma-glucose
#5
LETTER
Helen Lunt, Helen F Heenan, Peter Edwards, Christopher M Florkowski
No abstract text is available yet for this article.
November 8, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095698/validation-of-a-pneumatic-tube-system-to-transport-surgical-pathology-biopsy-samples
#6
LETTER
Briac Guibourg, Pascale Marcorelles, Arnaud Uguen
No abstract text is available yet for this article.
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095697/harmonization-in-laboratory-medicine-more-than-clinical-chemistry
#7
REVIEW
Mario Plebani
The goal of harmonizing laboratory information is to contribute to quality in patient care, ultimately improving upon patient outcomes and safety. The main focus of harmonization and standardization initiatives has been on analytical processes within the laboratory walls, clinical chemistry tests in particular. However, two major evidences obtained in recent years show that harmonization should be promoted not only in the analytical phase but also in all steps of the testing process, encompassing the entire field of laboratory medicine, including innovative areas (e...
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095696/method-comparison-a-practical-approach-based-on-error-identification
#8
EDITORIAL
Jacobus Petrus Johannes Ungerer, Carel Jacobus Pretorius
No abstract text is available yet for this article.
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095695/effect-of-haemolysis-on-the-determination-of-ccl17-thymus-and-activation-regulated-chemokine-tarc-and-ccl22-macrophage-derived-chemokine-mdc
#9
LETTER
Hermaleigh Townsley, Julian Crane, Rob Siebers
No abstract text is available yet for this article.
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095694/visual-assessment-of-hemolysis-affects-patient-safety
#10
Ana Helena Luksic, Nora Nikolac Gabaj, Marijana Miler, Lora Dukic, Ana Bakliza, Ana-Maria Simundic
BACKGROUND: Manual handling of hemolyzed samples is not standardized and is vulnerable to errors. This study aimed to evaluate laboratory errors due to manual handling of hemolyzed samples and to assess the risk they might have for patient safety. METHODS: Data were retrospectively obtained from a laboratory information system for 25 emergency tests from hemolyzed samples. Hemolysis (concentration of free hemoglobin >0.5 g/L) was visually assessed by comparison with a color chart...
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29095693/reference-intervals-for-stone-risk-factors-in-24-h-urine-among-healthy-adults-of-the-han-population-in-china
#11
Zanlin Mai, Xiaoxia Li, Zelin Cui, Wenqi Wu, Yongda Liu, Lili Ou, Yueping Liang, Zhijian Zhao, Yang Liu, Xing Mai, Wei Zhu, Tao Zhang, Chao Cai, Houmeng Yang, Guohua Zeng
BACKGROUND: The aim of the study was to establish reference intervals for 24-h urinary stone risk factors in the healthy Chinese Han population. METHODS: From May 2013 to July 2014, we collected and analyzed 24-h urine samples from healthy adult Han population during a cross-sectional study across China. The protocol for analysis of 24-h urine included volume, pH, oxalate, citrate, sodium, potassium, chloride, calcium, phosphorous, creatinine, urate, magnesium, the ion activity products of calcium oxalate (AP(CaOx) indexs) and calcium phosphate (AP(CaP) indexs)...
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29087954/a-transnational-collaborative-network-dedicated-to-the-study-and-applications-of-the-vascular-endothelial-growth-factor-a-in-medical-practice-the-vegf-consortium
#12
Maria G Stathopoulou, Ting Xie, Daniela Ruggiero, Jerome Chatelin, Marc Rancier, George Weryha, Mary Jo Kurth, Alex-Ander Aldasoro Arguinano, Vesna Gorenjak, Alexandros M Petrelis, Georges Dagher, George Dedoussis, Panagiotis Deloukas, John Lamont, Janja Marc, Maurizio Simmaco, Ron H N van Schaik, Federico Innocenti, Jean-Louis Merlin, Jochen Schneider, Behrooz Ziad Alizadeh, Marina Ciullo, Sudha Seshadri, Sophie Visvikis-Siest
No abstract text is available yet for this article.
October 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29087953/application-of-%C3%AE%C2%BA-free-light-chains-in-cerebrospinal-fluid-as-a-biomarker-in-multiple-sclerosis-diagnosis-development-of-a-diagnosis-algorithm
#13
Estefania Valencia-Vera, Ana Martinez-Escribano Garcia-Ripoll, Alfredo Enguix, Carmen Abalos-Garcia, Maria Jesus Segovia-Cuevas
BACKGROUND: The determination of κ free light chains (KFLC) in cerebrospinal fluid (CSF) by nephelometry is a feasible alternative to immunoglobulin G oligoclonal bands (OCB) in the evaluation of intrathecal synthesis of immunoglobulin in multiple sclerosis (MS) and other demyelinating diseases. The aim of this study was to assess the diagnostic value of KFLC and its inclusion in a procedure algorithm along with OCB interpretation. METHODS: A cross-sectional study, which included 123 patients with a CSF OCB request, was carried out...
October 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29055938/visual-assessment-of-sample-quality-quo-usque-tandem
#14
EDITORIAL
Giuseppe Lippi, Janne Cadamuro
No abstract text is available yet for this article.
October 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29055937/reaching-consensus-on-communication-of-critical-laboratory-results-using-a-collective-intelligence-method
#15
Maria Isabel Llovet, Carmen Biosca, Alicia Martínez-Iribarren, Aurora Blanco, Glòria Busquets, María José Castro, Maria Antonia Llopis, Mercè Montesinos, Joana Minchinela, Carme Perich, Judith Prieto, Rosa Ruiz, Núria Serrat, Margarita Simón, Alex Trejo, Josep Maria Monguet, Carlos López-Pablo, Mercè Ibarz
BACKGROUND: There is no consensus in the literature about what analytes or values should be informed as critical results and how they should be communicated. The main aim of this project is to establish consensual standards of critical results for the laboratories participating in the study. Among the project's secondary objectives, establishing consensual procedures for communication can be highlighted. METHODS: Consensus was reached among all participating laboratories establishing the basis for the construction of the initial model put forward for consensus in conjunction with the clinicians...
October 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29055936/machine-learning-in-laboratory-medicine-waiting-for-the-flood
#16
REVIEW
Federico Cabitza, Giuseppe Banfi
This review focuses on machine learning and on how methods and models combining data analytics and artificial intelligence have been applied to laboratory medicine so far. Although still in its infancy, the potential for applying machine learning to laboratory data for both diagnostic and prognostic purposes deserves more attention by the readership of this journal, as well as by physician-scientists who will want to take advantage of this new computer-based support in pathology and laboratory medicine.
October 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29040064/strong-impact-on-plasma-protein-profiles-by-precentrifugation-delay-but-not-by-repeated-freeze-thaw-cycles-as-analyzed-using-multiplex-proximity-extension-assays
#17
Qiujin Shen, Johan Björkesten, Joakim Galli, Daniel Ekman, John Broberg, Niklas Nordberg, Annika Tillander, Masood Kamali-Moghaddam, Gunnel Tybring, Ulf Landegren
Background A number of factors regarding blood collection, handling and storage may affect sample quality. The purpose of this study was to assess the impact on plasma protein profiles by delayed centrifugation and plasma separation and multiple freeze-thaw cycles. Methods Blood samples drawn from 16 healthy individuals were collected into ethylenediaminetetraacetic acid tubes and kept either at 4 °C or 22 °C for 1-36 h prior to centrifugation. Plasma samples prepared 1 h after venipuncture were also subjected to two to eight cycles of freezing at -80 °C and thawing at 22 °C...
October 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29040063/validation-of-the-six-sigma-z-score-for-the-quality-assessment-of-clinical-laboratory-timeliness
#18
Cristiano Ialongo, Sergio Bernardini
BACKGROUND: The International Federation of Clinical Chemistry and Laboratory Medicine has introduced in recent times the turnaround time (TAT) as mandatory quality indicator for the postanalytical phase. Classic TAT indicators, namely, average, median, 90th percentile and proportion of acceptable test (PAT), are in use since almost 40 years and to date represent the mainstay for gauging the laboratory timeliness. In this study, we investigated the performance of the Six Sigma Z-score, which was previously introduced as a device for the quantitative assessment of timeliness...
October 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29040062/influence-of-delayed-separation-of-plasma-from-whole-blood-on-cu-i-mn-se-and-zn-plasma-concentrations
#19
LETTER
Benoit Chovelon, Josiane Arnaud
No abstract text is available yet for this article.
October 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29031019/reply-to-analytical-evaluation-of-the-performances-of-diazyme-and-brahms-procalcitonin-applied-to-roche-cobas-in-comparison-with-brahms-pct-sensitive-kryptor
#20
Chong Yuan
No abstract text is available yet for this article.
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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