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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/28306524/improvement-of-the-sandell-kolthoff-reaction-method-ammonium-persulfate-digestion-for-the-determination-of-iodine-in-urine-samples
#1
Ana Machado, Lurdes Lima, Raquel B R Mesquita, Adriano A Bordalo
No abstract text is available yet for this article.
March 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306520/assessment-of-real-time-pcr-method-for-detection-of-egfr-mutation-using-both-supernatant-and-cell-pellet-of-malignant-pleural-effusion-samples-from-non-small-cell-lung-cancer-patients
#2
Saeam Shin, Juwon Kim, Yoonjung Kim, Sun-Mi Cho, Kyung-A Lee
BACKGROUND: EGFR mutation is an emerging biomarker for treatment selection in non-small-cell lung cancer (NSCLC) patients. However, optimal mutation detection is hindered by complications associated with the biopsy procedure, tumor heterogeneity and limited sensitivity of test methodology. In this study, we evaluated the diagnostic utility of real-time PCR using malignant pleural effusion samples. METHODS: A total of 77 pleural fluid samples from 77 NSCLC patients were tested using the cobas EGFR mutation test (Roche Molecular Systems)...
March 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306519/variability-in-variability-out-best-practice-recommendations-to-standardize-pre-analytical-variables-in-the-detection-of-circulating-and-tissue-micrornas
#3
Jenna Khan, Joshua A Lieberman, Christina M Lockwood
MicroRNAs (miRNAs) hold promise as biomarkers for a variety of disease processes and for determining cell differentiation. These short RNA species are robust, survive harsh treatment and storage conditions and may be extracted from blood and tissue. Pre-analytical variables are critical confounders in the analysis of miRNAs: we elucidate these and identify best practices for minimizing sample variation in blood and tissue specimens. Pre-analytical variables addressed include patient-intrinsic variation, time and temperature from sample collection to storage or processing, processing methods, contamination by cells and blood components, RNA extraction method, normalization, and storage time/conditions...
March 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28301317/challenges-in-the-analysis-of-epigenetic-biomarkers-in-clinical-samples
#4
José Luis García-Giménez, Salvador Mena-Mollá, Jesús Beltrán-García, Fabian Sanchis-Gomar
Epigenetic modifications represent an interesting landscape which can describe relevant features of human disease. Epigenetic biomarkers show several advantages as disease biomarkers because they provide information about gene function, specific endophenotypes and can even incorporate information from the environment and the natural history of disease. The improvement in genomic and epigenomic technologies has revolutionized the current comprehension of biological processes underlying health and disease. However, now is the time to adopt these new technologies to improve human health, thus converting this information into reliable biomarkers...
March 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28301316/a-new-approach-to-define-acceptance-limits-for-hematology-in-external-quality-assessment-schemes
#5
Mohamed Rida Soumali, Marjan Van Blerk, Abdelhadi Akharif, Stéphanie Albarède, Dagmar Kesseler, Gabriela Gutierrez, Barbara de la Salle, Inger Plum, Anne Guyard, Ana Paula Favia, Wim Coucke
BACKGROUND: A study performed in 2007 comparing the evaluation procedures used in European external quality assessment schemes (EQAS) for hemoglobin and leukocyte concentrations showed that acceptance criteria vary widely. For this reason, the Hematology working group from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM) decided to perform a statistical study with the aim of establishing appropriate acceptance limits (AL) allowing harmonization between the evaluation procedures of European EQAS organizers...
March 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28301315/time-and-age-dependent-decrease-of-nt-probnp-after-septal-myectomy-in-hypertrophic-obstructive-cardiomyopathy
#6
Hao Cui, Xi Wu, Shuiyun Wang, Bing Tang, Changsheng Zhu, Haibo Chen, Xiaohui Zhou, Rong Wu, Qinjun Yu, Xiaohong Huang
BACKGROUND: NT-proBNP level is a predictive factor in hypertrophic cardiomyopathy patients, in which left ventricular outflow tract obstruction contributes to an increased NT-proBNP level. However, studies regarding the influence of septal myectomy on NT-proBNP level in hypertrophic obstructive cardiomyopathy are lacking. METHODS: One hundred and eighty-two patients who underwent septal myectomy in Fuwai Hospital from May 2011 to March 2016 and were included in the present study...
March 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306526/a-simple-method-to-detect-biotin-interference-on-immunoassays
#7
Leo Lam, Campbell V Kyle
No abstract text is available yet for this article.
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306525/efficient-reporting-of-the-estimated-glomerular-filtration-rate-without-height-in-pediatric-patients-with-cancer
#8
Tae-Dong Jeong, Eun-Jung Cho, Woochang Lee, Sail Chun, Ki-Sook Hong, Won-Ki Min
BACKGROUND: The updated bedside Schwartz equation requires constant, serum creatinine concentration and height measurements to calculate the estimated glomerular filtration rate (eGFR) in pediatric patients. Unlike the serum creatinine levels, obtaining height information from the laboratory information system (LIS) is not always possible in a clinical laboratory. Recently, the height-independent eGFR equation, the full age spectrum (FAS) equation, has been introduced. We evaluated the performance of height-independent eGFR equation in Korean children with cancer...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306523/evaluation-of-thyroid-test-utilization-through-analysis-of-population-level-data
#9
Jasmine Gill, Vilte E Barakauskas, Dylan Thomas, Karina Rodriguez-Capote, Trefor Higgins, Don Zhang, Amanda VanSpronsen, Oksana Babenko, Roberta Martindale, Mathew P Estey
BACKGROUND: Inappropriate laboratory test utilization can result in unnecessary patient testing and increased healthcare costs. While several thyroid function tests are available, thyroid-stimulating hormone (TSH) is recommended as the first-line test for investigating and monitoring thyroid dysfunction. We evaluate thyroid test utilization in Northern Alberta in terms of testing patterns, frequencies, and reflex cutpoints. METHODS: This retrospective study analyzed thyroid test requests from January to December 2014...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306522/infrared-analyzers-for-breast-milk-analysis-fat-levels-can-influence-the-accuracy-of-protein-measurements
#10
Celia Kwan, Gerhard Fusch, Aldin Bahonjic, Niels Rochow, Christoph Fusch
BACKGROUND: Currently, there is a growing interest in lacto-engineering in the neonatal intensive care unit, using infrared milk analyzers to rapidly measure the macronutrient content in breast milk before processing and feeding it to preterm infants. However, there is an overlap in the spectral information of different macronutrients, so they can potentially impact the robustness of the measurement. In this study, we investigate whether the measurement of protein is dependent on the levels of fat present while using an infrared milk analyzer...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306521/reference-ranges-of-thromboelastometry-in-healthy-full-term-and-pre-term-neonates
#11
Rozeta Sokou, Leontini Foudoulaki-Paparizos, Theodore Lytras, Aikaterini Konstantinidi, Martha Theodoraki, Ioannis Lambadaridis, Antonis Gounaris, Serena Valsami, Marianna Politou, Argyri Gialeraki, Georgios K Nikolopoulos, Nicoletta Iacovidou, Stefanos Bonovas, Argirios E Tsantes
BACKGROUND: Rotational thromboelastometry (ROTEM) is an attractive method for rapid evaluation of hemostasis in neonates. Currently, no reference values exist for ROTEM assays in full-term and pre-term neonates. Our aim was to establish reference ranges for standard extrinsically activated ROTEM assay (EXTEM) in arterial blood samples of healthy full-term and pre-term neonates. METHODS: In the present study, EXTEM assay was performed in 198 full-term (≥37 weeks' gestation) and 84 pre-term infants (<37 weeks' gestation) using peripheral arterial whole blood samples...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28306518/biochemical-testing-in-a-laboratory-tent-and-semi-intensive-care-of-ebola-patients-on-site-in-a-remote-part-of-guinea-a-paradigm-shift-based-on-a-bleach-sensitive-point-of-care-device
#12
Leonid M Irenge, Jean-Michel Dindart, Jean-Luc Gala
BACKGROUND: During the West Africa Ebola virus disease (EVD) outbreak, a Belgian laboratory was deployed for supporting the Ebola treatment unit (ETU) of N'Zerekore, Guinea. Besides diagnosis of EVD and malaria, biochemical parameters were tested and used to guide supportive treatment of EVD. METHODS: To preserve analytes stability, lithium-heparin blood samples were analyzed using the i-STAT® point-of-care testing (POCT) handheld device without the viral inactivation step...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28284032/technical-and-clinical-validation-of-the-greiner-fc-mix-glycaemia-tube
#13
Eline A E van der Hagen, Marion J Fokkert, Amanda M D Kleefman, Marc H M Thelen, Sjoerd A A van den Berg, Robbert J Slingerland
BACKGROUND: Measurement of adequate glucose concentrations is complicated by in vitro breakdown of glucose due to glycolysis. Unlike the commonly used NaF-EDTA and NaF-oxalate phlebotomy tubes, citrated NaF-EDTA tubes are reported to directly and thereby completely inhibit glycolysis. Recently, Greiner introduced the Vacuette® FC-Mix NaF-EDTA-citrate tube, currently the only NaF-citrate tube without volume-disturbing liquid additions available on the European market. Here we present its potential as alternative for the laborious and therefore unfeasible conditions for glucose sampling as recommended by the World Health Organization (WHO)...
March 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28284031/immunoparesis-in-igm-gammopathies-as-a-useful-biomarker-to-predict-disease-progression
#14
Marcio Andrade-Campos, Ilda Murillo-Flórez, Ramón García-Sanz, Pilar Giraldo
BACKGROUND: The management of IgM monoclonal gammopathies undetermined significance (IgM-MGUS) and Waldenstrom's macroglobulinemia (WM) may be challenging. Modern immunoassays that quantify specific monoclonal heavy and light chain immunoglobulins are promising for their use in these applications. METHODS: Ninety consecutive patients (39 IgM-MGUS, 32 indolent WM [iWM], and 19 WM) seen between January 2007 and March 2014 were analyzed. Heavy/light chain (HLC) and serum free light chains assays (FLC) were determined at diagnosis to study their utility as biomarkers in IgM monoclonal gammopathies...
March 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28282292/s100b-maternal-blood-levels-are-gestational-age-and-gender-dependent-in-healthy-pregnancies
#15
Laura D Serpero, Vincenza Bianchi, Francesca Pluchinotta, Erika Conforti, Ekaterina Baryshnikova, Roberto Guaschino, Maurizio Cassinari, Oria Trifoglio, Maria Grazia Calevo, Diego Gazzolo
BACKGROUND: S100B is a well-established biomarker of central nervous system (CNS) development and damage in the perinatal period. Because the fetal CNS induces an overproduction of S100B measurable in the maternal bloodstream we evaluated S100B protein in healthy pregnancies in order to provide a reference curve of the protein in the second and third trimesters and to provide information on CNS development when standard monitoring procedures could be silent or unavailable. METHODS: Between July 2012 and December 2014 we conducted a prospective study in 1213 healthy pregnancies delivering healthy newborns...
March 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28282291/higher-serum-caspase-cleaved-cytokeratin-18-levels-during-the-first-week-of-sepsis-diagnosis-in-non-survivor-patients
#16
Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Raquel Ortiz López, José Ferreres, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Salomé Palmero, Manuel Buitrago, Alejandro Jiménez, Juan M Borreguero-León
BACKGROUND: Caspase-cleaved cytokeratin (CCCK)-18 is a protein released into the blood during apoptosis. Higher circulating CCCK-18 concentrations have been found in non-survivor than in survivor septic patients at moment of sepsis diagnosis. The following questions arise now: (1) How are serum CCCK-18 levels during the first week of sepsis? (2) Is there an association between sepsis severity and mortality and serum CCCK-18 levels during the first week? The aims of this study were to answer these questions...
March 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28282290/multidisciplinary-training-activities-for-decreasing-preanalytical-mistakes-in-samples-from-primary-care
#17
Adolfo Romero, Juan Gómez-Salgado, José Antonio Gómez-Fernández, Andrés Cobos, Carlos Ruiz-Frutos
BACKGROUND: The presence of preanalytical mistakes (PM) in samples from primary care centres (PCC) is a widely studied topic. Different correcting strategies have been proposed, with variable success. We planned a series of multidisciplinary sessions for clinical update, with the aim to decrease PM rates in samples from PCC. METHODS: The incidence of PM in samples from PCC processed at the laboratories of University Hospital Virgen de la Victoria (LAB1) and University Hospital Juan Ramon Jimenez (LAB2) was assessed during two time periods (October to November 2013 and January to May 2014)...
March 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28282289/relation-of-serum-%C3%AE-glutamyl-transferase-activity-with-copper-in-an-adult-population
#18
You-Fan Peng, Chun-Fang Wang, Guo-Gang Pan
BACKGROUND: The aim of this study was to evaluate the relationship between serum γ-glutamyl transferase (γ-GGT) activity and serum copper in an adult population. METHODS: We analyzed 281 adult subjects who regularly attended the physical examination center at the Affiliated Hospital of Youjiang Medical University for Nationalities. RESULTS: The demographic and laboratory data of the participants were divided into two groups according to the median of serum γ-GGT activity...
March 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28253195/new-perspectives-on-existing-data-in-comparative-measurements-a-simple-extension-of-the-regression-analysis
#19
Jürgen Durner, Michael Spannagl
No abstract text is available yet for this article.
March 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28253194/is-fasting-necessary-for-lipid-profile-determinations-some-considerations-from-the-perspective-of-the-clinical-laboratory
#20
Maria Carmen Lorenzo Lozano, Ana Cosmen Sanchez, Pedro María Belinchón Torres, Santiago Prieto Menchero, Daniel Pineda-Tenor
No abstract text is available yet for this article.
March 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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