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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/28426431/automated-detection-of-unstable-hemoglobin-variants-by-sysmex-xe-series-analyzers
#1
LETTER
Cláudia Teixeira, Daniela Pina, Maria Inês Freitas
No abstract text is available yet for this article.
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426430/great-need-for-changes-in-higher-education-in-greece
#2
LETTER
Ioannis Bakoyiannis, Veroniki Cherdyntseva, Maria Aivalioti, Maria Barton, Davide Coda, Ioanna Douka, Angelina Evangelou, Christos Evangelou, Petros Ioannou, Vasiliki Kanta, Konstantinos Kapanidis, Ioannis Karagiannidis, Damianos Kokkinidis, Sofia Kouni, Jamie Lehnen, Andreas Patsalos, Julian Pei, Peristera-Ioanna Petropoulou, William Rodemer, Diego Scerbo, Alketa Stefa, Elizar Tsvetkov, Lazaros Vasilikos, Themistoklis Vasilopoulos, Aleksandra Vukojicic, Efthalia Zafeiropoulou
No abstract text is available yet for this article.
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426429/a-candidate-liquid-chromatography-mass-spectrometry-reference-method-for-the-quantification-of-the-cardiac-marker-1-32-b-type-natriuretic-peptide
#3
Attila F Torma, Kate Groves, Sabine Biesenbruch, Chris Mussell, Alan Reid, Steve Ellison, Rainer Cramer, Milena Quaglia
BACKGROUND: B-type natriuretic peptide (BNP) is a 32 amino acid cardiac hormone routinely measured by immunoassays to diagnose heart failure. While it is reported that immunoassay results can vary up to 45%, no attempt of standardization and/or harmonization through the development of certified reference materials (CRMs) or reference measurement procedures (RMPs) has yet been carried out. METHODS: B-type natriuretic peptide primary calibrator was quantified traceably to the International System of Units (SI) by both amino acid analysis and tryptic digestion...
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412721/are-admission-procalcitonin-levels-universal-mortality-predictors-across-different-medical-emergency-patient-populations-results-from-the-multi-national-prospective-observational-triage-study
#4
Ramon Sager, Yannick Wirz, Devendra Amin, Adina Amin, Pierre Hausfater, Andreas Huber, Sebastian Haubitz, Alexander Kutz, Beat Mueller, Philipp Schuetz
BACKGROUND: Procalcitonin (PCT), an inflammatory blood biomarker, is well studied in infectious diseases. Its prognostic value in unselected emergency department (ED) patients remains yet undefined. Herein, we investigated association of admission PCT levels and mortality in a large, international-multicenter ED patient cohort. METHODS: We prospectively enrolled 6970 unselected, consecutive, adult, medical patients seeking ED care in three tertiary-care hospitals in Switzerland, France and the USA...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412720/mean-hemoglobin-concentrations-in-fasting-venous-and-non-fasting-capillary-blood-of-cambodian-women-using-a-hemoglobinometer-and-an-automated-hematology-analyzer
#5
LETTER
Crystal D Karakochuk, Aviva I Rappaport, Susan I Barr, Tim J Green
No abstract text is available yet for this article.
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412719/combined-measurement-of-factor-xiii-and-d-dimer-is-helpful-for-differential-diagnosis-in-patients-with-suspected-pulmonary-embolism
#6
Ning Tang, Ziyong Sun, Dengju Li, Jun Yang, Shiyu Yin, Qing Guan
BACKGROUND: D-dimer has been used to rule out pulmonary embolism (PE). Based on previous reports of decreased concentrations of coagulation factor XIII (FXIII) in venous thromboembolism, and no change in FXIII concentration in patients with acute cardiovascular disease, we evaluated the benefit of simultaneously measuring D-dimer and FXIII concentrations for diagnosing PE. METHODS: In this prospective single-center study, we enrolled 209 patients initially suspected of having PE, and measured their D-dimer and FXIII concentrations...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412718/prognostic-value-of-total-antioxidant-capacity-to-predict-functional-outcome-in-traumatic-brain-injury-patients
#7
LETTER
Ana Rodríguez-Rodríguez, Juan José Egea-Guerrero, Ángel Vilches-Arenas, Elena Gordillo-Escobar, Zaida Ruiz de Azúa-López, Francisco Murillo-Cabezas
No abstract text is available yet for this article.
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28412717/fibrinogen-determination-according-to-clauss-commutability-assessment-of-international-and-commercial-standards-and-quality-control-samples
#8
Antonius M H P van den Besselaar, Claudia J J van Rijn, Christa M Cobbaert, G Louis A Reijnierse, Martine J Hollestelle, René W L M Niessen, Francisca Hudig
BACKGROUND: Many clinical laboratories use a clotting rate assay according to Clauss for the determination of fibrinogen in citrated plasma. The aim of the present study was to assess the commutability of the current International Standard for fibrinogen (coded 09/264), three commercial fibrinogen standards, and 10 freeze-dried plasma quality control samples from various sources. METHODS: Clotting rate assays according to Clauss were performed on three automated instruments (Sysmex CA1500, STA-Rack Evolution and ACL-Top 700), using three commercial thrombin reagents (Siemens, Stago, and Instrumentation Laboratory)...
April 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28391253/stability-of-procalcitonin-in-cerebrospinal-fluid
#9
LETTER
Kirsten R I S Dorresteijn, Korné Jellema, Gabriëlle A E Ponjee, Rolf J Verheul
No abstract text is available yet for this article.
April 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28391252/the-cortisol-cbg-ratio-affects-cortisol-immunoassay-bias-at-elevated-cbg-concentrations
#10
LETTER
Michel J Vos, Peter H Bisschop, Martine M L Deckers, Erik Endert
No abstract text is available yet for this article.
April 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28391251/gestational-age-specific-reference-intervals-for-serum-thyroid-hormone-levels-in-a-multi-ethnic-population
#11
Clement K M Ho, Edward T H Tan, Mor Jack Ng, George S H Yeo, Bernard Chern, Nancy W S Tee, Kenneth Y C Kwek, Kok Hian Tan
BACKGROUND: Thyroid disorders are common during pregnancy. To date, a limited number of studies have reported differences in serum thyroid hormone concentrations between different ethnic groups. We sought to establish gestational age-specific reference intervals for serum levels of thyroid hormones in a multi-ethnic population and investigate whether separate reference intervals should be used for different ethnic groups. METHODS: A total of 926 pregnant women from multiple ethnic groups attended four separate study visits spanning the three trimesters...
April 10, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28384100/mass-spectrometry-or-immunoassay-est-modus-in-rebus
#12
EDITORIAL
Giorgia Antonelli, Mariela Marinova, Carlo Artusi, Mario Plebani
No abstract text is available yet for this article.
April 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28375844/a-note-from-the-editor-in-chief-regarding-the-letter-to-the-editor-great-need-for-changes-in-higher-education-in-greece
#13
EDITORIAL
Mario Plebani
No abstract text is available yet for this article.
April 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28375843/a-new-immunochemistry-platform-for-a-guideline-compliant-cardiac-troponin-t-assay-at-the-point-of-care-proof-of-principle
#14
Eloisa Lopez-Calle, Pamela Espindola, Juergen Spinke, Sascha Lutz, Alfons Nichtl, Armin Tgetgel, Nicolas Herbert, Moritz Marcinowski, Juergen Klepp, Thomas Fischer, Thorsten Brueckner, Christoph Boehm, Thomas Keller
BACKGROUND: A multitude of troponin assays for the point-of-care (POC) have been developed showing a lack of analytical sensitivity and precision. We present a new platform solution for the high-sensitivity detection of cardiac troponin T (cTnT) in a 30 μL whole blood sample with a turnaround time of 11 min. METHODS: The immunoassay was completely run in a ready-to-use plastic disposable, a centrifugal microfluidic disc with fully integrated reagents. After the sample application, the assay was automatically processed by separating the cellular blood components via centrifugation, followed by incubation of a defined volume from the generated plasma with the immunoreagents...
April 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28375842/between-laboratory-analysis-of-igg-antibodies-against-aspergillus-fumigatus-in-paired-quality-control-samples
#15
LETTER
Albert W van Toorenenbergen, Joep J M Kurstjens
No abstract text is available yet for this article.
April 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28361782/laboratory-testing-in-the-emergency-department-an-italian-society-of-clinical-biochemistry-and-clinical-molecular-biology-sibioc-and-academy-of-emergency-medicine-and-care-acemc-consensus-report
#16
Giuseppe Lippi, Mauro Panteghini, Sergio Bernardini, Laura Bonfanti, Paolo Carraro, Ivo Casagranda, Mario Cavazza, Ferruccio Ceriotti, Marcello Ciaccio, Daniele Coen, Davide Giavarina, Fabrizio Giostra, Ciro Paolillo, Mario Plebani, Giorgio Ricci, Gianfranco Cervellin
BACKGROUND: The mainstay of patient-oriented laboratory testing in emergency settings entails selecting a number and the type of tests according to valid criteria of appropriateness. Since the pattern of urgent tests requesting is variable across different institutions, we designed a joined survey between the Academy of Emergency Medicine and Care (AcEMC) and the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC) for reaching tentative consensus about the most informative diagnostic tests in emergency settings...
March 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28361781/serum-complexed-and-free-prostate-specific-antigen-psa-for-the-diagnosis-of-the-polycystic-ovarian-syndrome-pcos
#17
Eleftherios P Diamandis, Frank Z Stanczyk, Sarah Wheeler, Anu Mathew, Martin Stengelin, Galina Nikolenko, Eli N Glezer, Marshall D Brown, Yingye Zheng, Yen-Hao Chen, Hsiao-Li Wu, Ricardo Azziz
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS. METHODS: We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA...
March 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28361780/a-candidate-reference-method-for-serum-potassium-measurement-by-inductively-coupled-plasma-mass-spectrometry
#18
Ying Yan, Bingqing Han, Jie Zeng, Weiyan Zhou, Tianjiao Zhang, Jiangtao Zhang, Wenxiang Chen, Chuanbao Zhang
BACKGROUND: Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important. METHODS: An inductively coupled plasma mass spectrometry (ICP-MS) method was developed. Serum samples were gravimetrically spiked with an aluminum internal standard, digested with 69% ultrapure nitric acid, and diluted to the required concentration...
March 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28350535/relationship-between-polymorphisms-in-the-crp-lep-and-lepr-genes-and-high-sensitivity-c-reactive-protein-levels-in-spanish-children
#19
Pilar Navarro, Olaya de Dios, Teresa Gavela-Pérez, Leandro Soriano-Guillen, Carmen Garcés
BACKGROUND: We investigated the association of single nucleotide polymorphisms (SNPs) in the C-reactive protein (CRP), leptin (LEP) and leptin receptor (LEPR) genes with high sensitivity CRP (hs-CRP) levels in two independent cohorts of healthy Spanish children. METHODS: We measured hs-CRP levels in 646 6-8-year-old and 707 12-16-year-old children using a high-sensitivity C-Reactive Protein ELISA kit. Four SNPs in the CRP gene (rs1205, rs1130864, rs2794521 and rs1800947), one SNP in the LEP gene (rs7799039) and two SNPs in the LEPR (rs1137100 and rs1137101) gene were determined by TaqMan® allelic discrimination assays...
March 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28350534/evaluation-of-a-poct-device-for-c-reactive-protein-hematocrit-and-leukocyte-differential
#20
Albert J de Graaf, Sietske W Hiemstra, Evelien W M Kemna, Johannes G Krabbe
No abstract text is available yet for this article.
March 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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