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Clinical Chemistry and Laboratory Medicine: CCLM

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https://www.readbyqxmd.com/read/29329103/analysis-of-anti-ganglioside-antibodies-by-a-line-immunoassay-in-patients-with-chronic-inflammatory-demyelinating-polyneuropathies-cidp
#1
Juliane Klehmet, Stefanie Märschenz, Klemens Ruprecht, Benjamin Wunderlich, Thomas Büttner, Rico Hiemann, Dirk Roggenbuck, Andreas Meisel
BACKGROUND: Unlike for acute immune-mediated neuropathies (IN), anti-ganglioside autoantibody (aGAAb) testing has been recommended for only a minority of chronic IN yet. Thus, we used a multiplex semi-quantitative line immunoassay (LIA) to search for aGAAb in chronic-inflammatory demyelinating polyneuropathy (CIDP) and its clinical variants. METHODS: Anti-GAAb to 11 gangliosides and sulfatide (SF) were investigated by LIA in 61 patients with IN (27 typical CIDP, 12 distal-acquired demyelinating polyneuropathy, 6 multifocal-acquired demyelinating sensory/motor polyneuropathy, 10 sensory CIDP, 1 focal CIDP and 5 multifocal-motoric neuropathy), 40 with other neuromuscular disorders (OND) (15 non-immune polyneuropathies, 25 myasthenia gravis), 29 with multiple sclerosis (MS) and 54 healthy controls (HC)...
January 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29320363/performance-evaluation-of-a-new-automated-fourth-generation-hiv-ag-ab-combination-chemiluminescence-immunoassay
#2
LETTER
Yanhua Zhao, Yu Gou, Dongdong Li, Tingting Wang, Xiyue Huang, Mingqiao Shi, Chuanmin Tao
No abstract text is available yet for this article.
January 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29320362/predictive-value-of-serum-gelsolin-and-gc-globulin-in-sepsis-a-pilot-study
#3
Zoltán Horváth-Szalai, Péter Kustán, Balázs Szirmay, Ágnes Lakatos, Per Hjort Christensen, Tamás Huber, Beáta Bugyi, Diána Mühl, Andrea Ludány, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
BACKGROUND: Simultaneous determination of the two main actin scavenger proteins in sepsis has not been investigated until now. In our pilot study, we elucidated the predictive values of Gc globulin and gelsolin (GSN) in sepsis by comparing them to classic laboratory and clinical parameters. METHODS: A 5-day follow-up was performed, including 46 septic patients, 28 non-septic patients and 35 outpatients as controls. Serum Gc globulin and GSN levels were determined by automated immune turbidimetric assay on a Cobas 8000/c502 analyzer...
January 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29315076/independent-evaluation-using-fresh-patient-samples-under-real-clinical-conditions-is-vital-for-confirming-the-suitability-and-marketability-of-any-new-hba1c-assay-an-example
#4
LETTER
Erna Lenters-Westra
No abstract text is available yet for this article.
January 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29315075/gamma-heavy-chain-disease-evolving-during-the-progression-of-chronic-lymphocytic-leukemia
#5
LETTER
Christoph Robier, Manfred Neubauer
No abstract text is available yet for this article.
January 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29315074/precision-accuracy-cross-reactivity-and-comparability-of-serum-indices-measurement-on-abbott-architect-c8000-beckman-coulter-au5800-and-roche-cobas-6000-c501-clinical-chemistry-analyzers
#6
Nora Nikolac Gabaj, Marijana Miler, Alen Vrtarić, Marina Hemar, Petra Filipi, Marija Kocijančić, Vesna Šupak Smolčić, Ivana Ćelap, Ana-Maria Šimundić
BACKGROUND: The aim of our study was to perform verification of serum indices on three clinical chemistry platforms. METHODS: This study was done on three analyzers: Abbott Architect c8000, Beckman Coulter AU5800 (BC) and Roche Cobas 6000 c501. The following analytical specifications were verified: precision (two patient samples), accuracy (sample with the highest concentration of interferent was serially diluted and measured values compared to theoretical values), comparability (120 patients samples) and cross reactivity (samples with increasing concentrations of interferent were divided in two aliquots and remaining interferents were added in each aliquot...
January 9, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306918/3q29-microduplication-in-a-small-family-with-complex-metabolic-phenotype-from-southern-italy
#7
LETTER
Andrea Vitale, Giuseppe Labruna, Annamaria Mancini, Andreina Alfieri, Laura Iaffaldano, Carmela Nardelli, Fabrizio Pasanisi, Lucio Pastore, Pasqualina Buono, Barbara Lombardo
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306917/site-specific-dna-methylation-detection-based-on-enzyme-linked-immunosorbent-assay-using-recombinant-methyl-cpg-binding-protein
#8
LETTER
Wei Wu, Lin Wang, Yang Liu, Dou Wang, Tulong Huang, Baishan Jiang, Zhiyuan Fang
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306916/falsely-elevated-plasma-testosterone-concentrations-in-neonates-importance-of-lc-ms-ms-measurements
#9
LETTER
Henrike M Hamer, Martijn J J Finken, Antonius E van Herwaarden, Therina du Toit, Amanda C Swart, Annemieke C Heijboer
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306915/screening-for-connective-tissue-disease-associated-antibodies-by-automated-immunoassay
#10
Philippe Willems, Ellen De Langhe, Jolien Claessens, René Westhovens, Erna Van Hoeyveld, Koen Poesen, Steven Vanderschueren, Daniel Blockmans, Xavier Bossuyt
BACKGROUND: Antinuclear antibodies (ANAs) are useful for the diagnosis of ANA-associated systemic rheumatic disease (AASRD). The objective of this study was the evaluation of an immunoassay that detects antibodies to a mixture of 17 antigens as an alternative to indirect immunofluorescence (IIF). METHODS: Nine thousand eight hundred and fifty-six consecutive patients tested for ANAs were tested by IIF and EliA connective tissue disease screen (Thermo-Fisher). Medical records were reviewed for 2475 patients, including all patients that tested positive/equivocal by either test and a selection of 500 patients that tested negative...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306914/diagnostic-performance-of-the-n-terminal-pro-brain-natriuretic-peptide-to-detect-an-increased-left-atrial-pressure-in-patients-with-persistent-atrial-fibrillation
#11
LETTER
Michitaka Amioka, Akinori Sairaku, Yukiko Nakano, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Naoya Hironobe, Yasuki Kihara
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306913/diagnosis-of-acute-pediatric-appendicitis-from-children-with-inflammatory-diseases-by-combination-of-metabolic-markers-and-inflammatory-response-variables
#12
Mengjie Yu, Tianxin Xiang, Xiaoping Wu, Shouhua Zhang, Wenlong Yang, Yu Zhang, Qiang Chen, Shuilin Sun, Baogang Xie
BACKGROUND: The discovery of new metabolic markers may be helpful for early diagnosis of acute pediatric appendicitis (APA). However, no studies have been reported regarding identification of potential metabolic markers for the APA diagnosis by metabonomics. METHODS: Serum samples of APA (n=32), non-appendicitis inflammation (NAI, n=32) and healthy children (HS, n=65) were analyzed by the 1H NMR-based metabonomics. A logistic regression model was established to screen the most efficient markers combinations for classification...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306912/lc-msms-assays-of-urinary-cortisol-a-comparison-between-four-in-house-assays
#13
Julie Brossaud, Monique Leban, Jean-Benoit Corcuff, Florence Boux de Casson, Anne-Gaëlle Leloupp, Damien Masson, Valérie Moal, Kalyane Bach-Ngohou
BACKGROUND: Twenty-four hour urinary free cortisol (UFC) determination can be used for screening and follow-up of Cushing syndrome (CS). As immunoassay methods lack specificity for UFC measurement, the use of high-performance liquid chromatography coupled to mass spectrometer (LC-MSMS) is recommended. The aim of our study was to compare UFC results using four LC-MSMS methods performed in four independent laboratories in order to evaluate interlaboratory agreement. METHODS: Frozen aliquots of 24-h urine samples (78 healthy volunteers and 20 patients with CS) were sent to four different laboratories for analysis...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306911/false-increase-of-glycated-hemoglobin-due-to-aspirin-interference-in-tosoh-g8-analyzer
#14
LETTER
Charlotte Gils, Birgitte Reinholdt, Bjarne Damgaard Andreassen, Ivan Brandslund, Pernille Just Vinholt
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306910/is-the-dna-of-placental-origin-packaged-in-exosomes-isolated-from-plasma-and-serum-of-pregnant-women
#15
LETTER
Gabriela Repiská, Barbora Konečná, Ganesh V Shelke, Cecilia Lässer, Barbora Izrael Vlková, Gabriel Minárik
No abstract text is available yet for this article.
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306909/detection-of-egfr-kras-and-braf-mutations-in-metastatic-cells-from-cerebrospinal-fluid
#16
Diane Frankel, Isabelle Nanni-Metellus, Andrée Robaglia-Schlupp, Pascale Tomasini, Julien Guinde, Fabrice Barlesi, Philippe Astoul, L'Houcine Ouafik, Florent Amatore, Véronique Secq, Elise Kaspi, Patrice Roll
BACKGROUND: In lung adenocarcinoma, molecular profiling of actionable genes has become essential to set up targeted therapies. However, the feasibility and the relevance of molecular profiling from the cerebrospinal fluid (CSF) in the context of meningeal metastasis have been poorly assessed. METHODS: We selected patients with stage IV lung adenocarcinoma harbouring metastatic cells in the CSF after cytological analysis. Seven samples from six patients were eligible for molecular testing of epidermal growth factor receptor (EGFR), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS), v-Raf murine sarcoma viral oncogene homologue B1 (BRAF) and human epidermal growth factor receptor 2 (HER2) mutations using quantitative polymerase chain reaction (PCR) high-resolution melting curve analysis and Sanger sequencing after DNA extraction from the cell pellets of the CSF...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306908/systematic-comparison-of-routine-laboratory-measurements-with-in-hospital-mortality-icu-labome-a-large-cohort-study-of-critically-ill-patients
#17
Edris M Alkozai, Bakhtawar K Mahmoodi, Johan Decruyenaere, Robert J Porte, Annemieke Oude Lansink-Hartgring, Ton Lisman, Maarten W Nijsten
BACKGROUND: In intensive care unit (ICU) patients, many laboratory measurements can be deranged when compared with the standard reference interval (RI). The assumption that larger derangements are associated with worse outcome may not always be correct. The ICU-Labome study systematically evaluated the univariate association of routine laboratory measurements with outcome. METHODS: We studied the 35 most frequent blood-based measurements in adults admitted ≥6 h to our ICU between 1992 and 2013...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29305566/an-update-report-on-the-harmonization-of-adult-reference-intervals-in-australasia
#18
Gus Koerbin, Ken Sikaris, Graham R D Jones, Robert Flatman, Jillian R Tate
The Australasian Association of Clinical Biochemists (AACB) has over the past 5 years been actively working to achieve harmonized reference intervals (RIs) for common clinical chemistry analytes using an evidence-based checklist approach where there is sound calibration and metrological traceability. It has now recommended harmonized RIs for 18 common clinical chemistry analytes which are performed in most routine laboratories and these have been endorsed by the Royal College of Pathologists of Australasia (RCPA)...
January 6, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29305565/gstp1-methylation-in-cancer-a-liquid-biopsy-biomarker
#19
REVIEW
Giorgia Gurioli, Filippo Martignano, Samanta Salvi, Matteo Costantini, Roberta Gunelli, Valentina Casadio
The coding region of GSTP1 gene is preceded by a large CpG-rich region that is frequently affected by methylation. In many cancer types, GSTP1 is affected by hypermethylation and, as a consequence, it has a low expression. The aim of this review is to give an overview on GSTP1 methylation studies with a special focus on liquid biopsy, thus to summarize methods, results, sample types, different diseases, to have a complete information regarding this promising epigenetic biomarker. We used all the most valuable scientific search engines (PubMed, Medline, Scopus and Web of Science) searching the following keywords: GSTP1, methylation, cancer, urine, serum, plasma and blood...
January 6, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29303774/repeat-requesting-on-hemolysed-plasma-potassium-requests
#20
LETTER
Robert C Hawkins
No abstract text is available yet for this article.
January 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
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