Linlin Qin, Bao Hu, Kiel D Neumann, Ethan J Linstad, Katelyenn McCauley, Jordan Veness, Jayson J Kempinger, Stephen G DiMagno
Diaryliodonium salts are powerful and widely used arylating agents in organic chemistry. Here we report a scalable, synthesis of densely functionalized diaryliodonium salts from aryl iodides under mild conditions. This two-step, one-pot process has remarkable functional group tolerance, is compatible with commonly employed acid-labile protective group strategies, avoids heavy metal and transition metal reagents, and provides a direct route to stable precursors to PET imaging agents.
September 1, 2015: European Journal of Organic Chemistry