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Sexually Transmitted Infections

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https://www.readbyqxmd.com/read/30242143/prevalence-and-correlates-of-and-a-risk-score-to-identify-asymptomatic-anorectal-gonorrhoea-and-chlamydia-infection-among-men-who-have-sex-with-men-in-kisumu-kenya
#1
Laura A S Quilter, Eve Obondi, Colin Kunzweiler, Duncan Okall, Robert C Bailey, Gaston Djomand, Boaz Otieno-Nyunya, Fredrick Otieno, Susan M Graham
OBJECTIVES: In settings where laboratory capacity is limited, the WHO recommends presumptive treatment for Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in asymptomatic men who have sex with men (MSM) at high risk for these infections. However, little is known about how best to target this intervention. We aimed to identify correlates of anorectal NG/CT infection in Kenyan MSM with and without anorectal symptoms and evaluate the performance of an empirical, model-based risk score to identify cases in asymptomatic men...
September 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30228109/sexually-transmitted-infections-during-pregnancy-and-subsequent-risk-of-stillbirth-and-infant-mortality-in-kenya-a-prospective-study
#2
Alex J Warr, Jillian Pintye, John Kinuthia, Alison L Drake, Jennifer A Unger, R Scott McClelland, Daniel Matemo, Lusi Osborn, Grace John-Stewart
OBJECTIVES: We evaluated the relationship of sexually transmitted infections (STIs) and genital infections during pregnancy and subsequent risk for infant mortality and stillbirth. METHODS: This was a nested longitudinal analysis using data from a study of peripartum HIV acquisition in Kenya. In the parent study, HIV-uninfected women were enrolled during pregnancy and followed until 9 months postpartum. For this analysis, women who tested positive for HIV at any point, had a non-singleton pregnancy or a spontaneous abortion <20 weeks were excluded...
September 18, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30196273/microscopic-examination-of-gram-stained-smears-for-anogenital-gonorrhoea-in-men-who-have-sex-with-men-is-cost-effective-evidence-from-a-modelling-study
#3
Jolijn M Zwart, Marie-Josee J Mangen, Menne Bartelsman, Martijn S van Rooijen, Henry J C de Vries, Maria Xiridou
OBJECTIVE: To assess the cost-effectiveness of three testing strategies with or without light microscopic Gram-stained smear (GSS) evaluation for the detection of anogenital gonorrhoea among men who have sex with men (MSM) at the Amsterdam STI clinic using a healthcare payer perspective. METHODS: Three testing strategies for MSM were compared: (1) GSS in symptomatic MSM only (currently practised strategy), (2) no GSS and (3) GSS in symptomatic and asymptomatic MSM...
September 8, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30181327/does-infection-with-chlamydia-trachomatis-induce-long-lasting-partial-immunity-insights-from-mathematical-modelling
#4
Ryosuke Omori, Hiam Chemaitelly, Christian L Althaus, Laith J Abu-Raddad
OBJECTIVES: To explore whether existence of long-lasting partial immunity against reinfection with Chlamydia trachomatis is necessary to explain C. trachomatis prevalence patterns by age and sexual risk, and to provide a plausible estimate for the effect size, defined here as a reduction in susceptibility to reinfection. METHODS: A population-based mathematical model was constructed to describe C. trachomatis natural history and transmission dynamics by age and sexual risk...
September 4, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30181326/cross-sectional-study-of-urethral-exposures-at-last-sexual-episode-associated-with-non-gonococcal-urethritis-among-std-clinic-patients
#5
Laura C Chambers, Jennifer L Morgan, M Sylvan Lowens, Tashina S Robinson, Sarah S Romano, Gina L Leipertz, James P Hughes, Matthew R Golden, Christine M Khosropour, David N Fredricks, Lisa E Manhart
OBJECTIVE: Although Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) are major causes of non-gonococcal urethritis (NGU), up to 50% of cases are of unknown aetiology. We sought to identify urethral exposures at last sexual episode associated with NGU and non-CT/non-MG NGU to identify anatomical sites from which aetiologically relevant micro-organisms may be acquired. METHODS: We enrolled STD clinic patients with and without NGU assigned male sex at birth and age ≥16 into a cross-sectional study...
September 4, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30171173/are-associations-between-hiv-and-human-papillomavirus-transmission-due-to-behavioural-confounding-or-biological-effects
#6
Cari van Schalkwyk, Jennifer Moodley, Alex Welte, Leigh Francis Johnson
OBJECTIVES: Cohort studies have shown significant increased risk of HIV acquisition following human papillomavirus (HPV) detection and increased risk of new HPV detection in individuals with HIV infection, after adjusting for behavioural risk factors. This study uses an individual-based model to assess whether confounding sexual behaviour factors and network level effects can explain these associations between HIV and HPV infection status, without biological interactions. METHODS: The model simulates infection with 13 oncogenic HPV types and HIV...
August 31, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30171172/legislation-and-regulation-in-the-era-of-online-sexual-health-how-do-we-ensure-provision-of-safe-high-quality-care
#7
Jo Gibbs, Soazig Clifton, Pam Sonnenberg, Ann Blandford, Anne M Johnson, Claudia S Estcourt
No abstract text is available yet for this article.
August 31, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30171171/foster-care-syndemic-health-disparities-and-associations-with-hiv-sti-diagnoses-among-young-adult-substance-users
#8
Mance E Buttram, Maria E Pagano, Steven P Kurtz
OBJECTIVES: Foster care history is associated with many health and social problems, including sexual risk behaviours, HIV and other sexually transmitted infections (STIs). This cross-sectional study compares sexual risk behaviours among a sample of young adult substance users in Miami (N=602) with and without foster care histories. METHODS: Participants completed a comprehensive assessment which included sections on foster care, sexual risk behaviours and related health and social problems...
August 31, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30171170/usage-of-purchased-self-tests-for-hiv-infections-among-migrants-living-in-the-uk-france-and-the-netherlands-a-cross-sectional-study
#9
Janneke P Bil, Maria Prins, Ibidun Fakoya, Alain Volny-Anne, Fiona Burns, Freke R Zuure
OBJECTIVES: Self-tests are performed and interpreted autonomously by a person without involving a healthcare professional or a certified laboratory. To gain insight into the usage of purchased HIV self-tests (HIVST) among migrants living in high-income countries, we studied the prevalence and determinants of HIVST usage among migrants living in the UK, France and the Netherlands. METHODS: We used web-based questionnaire data collected between April 2014 and July 2015 among migrants living in the UK, France and the Netherlands who participated in the cross-sectional community survey of the aMASE (advancing Migrant Access to health Services in Europe) study...
August 31, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30154157/aptima-trichomonas-vaginalis-assay-elucidates-significant-underdiagnosis-of-trichomoniasis-among-women-in-brazil-according-to-an-observational-study
#10
Mirian Pinheiro Bruni, Mariangela Freitas da Silveira, Dulce Stauffert, Guilherme Lucas de Oliveira Bicca, Carolina Caetano Dos Santos, Nara Amélia da Rosa Farias, Daniel Golparian, Magnus Unemo
OBJECTIVES: Trichomonas vaginalis (TV) infection is the most common non-viral STI globally and can result in adverse pregnancy outcomes and exacerbated HIV acquisition/transmission. Nucleic acid amplification tests (NAATs) are the most sensitive diagnostic tests, with high specificity, but TV NAATs are rarely used in Brazil. We investigated the TV prevalence and compared the performance of the US Food and Drug Association-cleared Aptima TV assay with microscopy (wet mount and Gram-stained) and culture for TV detection in women in Pelotas, Brazil in an observational study...
August 28, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30150251/sexually-transmitted-infections-in-the-delta-regional-authority-significant-disparities-in-the-252-counties-of-the-eight-state-delta-region-authority
#11
Alexandra C Barger, William S Pearson, Christofer Rodriguez, David Crumly, Georgia Mueller-Luckey, Wiley D Jenkins
OBJECTIVE: Chlamydia, gonorrhoea and syphilis (primary and secondary) are at high levels in the USA. Disparities by race, gender and sexual orientation have been characterised, but while there are indications that rural poor populations may also be at distinct risk this has been subjected to little study by comparison. The federally designated Delta Regional Authority, similar in structure to the Appalachian Regional Commission, oversees 252 counties within eight Mississippi Delta states experiencing chronic economic and health disparities...
August 27, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30126949/club-drug-users-had-higher-odds-of-reporting-a-bacterial-sti-compared-with-non-club-drug-users-results-from-a-cross-sectional-analysis-of-gay-and-bisexual-men-on-hiv-pre-exposure-prophylaxis
#12
Steven A John, Jeffrey T Parsons, H Jonathon Rendina, Christian Grov
OBJECTIVES: Pre-exposure prophylaxis (PrEP) can reduce HIV transmission risk for many gay, bisexual and other men who have sex with men. However, bacterial STI (BSTI) associated with decreasing condom use among HIV PrEP users is a growing concern. Determining the characteristics of current PrEP users at highest BSTI risk fills a critical gap in the literature. METHODS: Gay and bisexual men (GBM) in New York City on HIV PrEP for 6 or more months (n=65) were asked about chlamydia, gonorrhoea and syphilis diagnoses in the past 6 months...
August 20, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30126948/bridging-the-hiv-syphilis-testing-gap-dual-testing-among-men-who-have-sex-with-men-living-in-china
#13
Jason J Ong, Meizhen Liao, Amy Lee, Hongyun Fu, Stephen W Pan, Weiming Tang, Chongyi Wei, Wu Dan, Bin Yang, Ligang Yang, Cheng Wang, Joseph D Tucker
OBJECTIVES: The WHO recommends dual testing for HIV and syphilis among key populations, including men who have sex with men (MSM). We assessed the proportion of men who had dual tested and reasons for not dual testing. METHODS: In 2017, an online survey of MSM was conducted in eight cities from two provinces in China. Data on sociodemographics and sexual behaviours were collected. Descriptive analysis was used to examine the experience of dual testing. Multivariable logistic regression identified characteristics associated with men who had dual tested...
August 20, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30126947/detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-with-the-cobas-ct-ng-v2-0-test-performance-compared-with-the-bd-probetec-ct-q-x-and-gc-q-x-amplified-dna-and-aptima-ac2-assays
#14
Melinda B Nye, John Osiecki, Michael Lewinski, Oliver Liesenfeld, Stephen Young, Stephanie N Taylor, Rebecca A Lillis, Barbara A Body, Carol Eisenhut, Edward W Hook Iii, Barbara Van Der Pol
OBJECTIVES: Infections due to Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are among the most common bacterial sexually transmitted infections worldwide, most of which are asymptomatic. Detection of infection using a variety of specimen types in symptomatic and asymptomatic subjects is important to effectively combat CT/NG infections. The performance of the cobas CT/NG v2.0 test was assessed for urogenital swabs, urine and cervical cytology samples collected in PreservCyt Solution from 5266 symptomatic and asymptomatic women (including 202 who were pregnant), and urine from 738 men...
August 20, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30126946/field-evaluation-of-a-smartphone-based-electronic-reader-of-rapid-dual-hiv-and-syphilis-point-of-care-immunoassays
#15
Lao-Tzu Allan-Blitz, Silver K Vargas, Kelika A Konda, Sasha Herbst de Cortina, Carlos F Cáceres, Jeffrey D Klausner
OBJECTIVE: Electronic (E) devices read and quantify lateral flow-based rapid tests, providing a novel approach to assay interpretation. We evaluated the performance of one E-reader for two dual HIV and syphilis immunoassays. METHODS: We enrolled men who have sex with men and transgender women >18 years of age seeking medical services at an STD clinic in Lima, Peru, between October 2016 and April 2017. Venous blood was tested using two dual HIV and syphilis antibody immunoassays (SD BIOLINE HIV/Syphilis Duo, Republic of Korea, and First Response HIV 1+2/Syphilis Combo, India)...
August 20, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30082332/changing-face-of-the-syphilis-epidemic-in-men-who-have-sex-with-men
#16
Sarah Taine, Claire Norcross, Nicolas Pinto-Sander, Colin Fitzpatrick, Daniel Richardson
No abstract text is available yet for this article.
August 6, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30072393/dried-blood-spot-and-mini-tube-blood-sample-collection-kits-for-postal-hiv-testing-services-a-comparative-review-of-successes-in-a-real-world-setting
#17
Matthew Page, Sowsan F Atabani, Martyn Wood, Erasmus Smit, Steven Wilson, Carol Atherton, Clare F Davenport, Daniel Hartland, Mark Simpson, Stephen Taylor
OBJECTIVES: This is a comparative review between using dried blood spot (DBS) and mini-tube (MT) HIV sampling kits as part of an online sexually transmitted infection (STI) postal testing service. England has recently seen increases in internet-based and postal (eHealth) STI services. Expanding accessibility and testing for patients, cost implications and narrowing the HIV undiagnosed margin are drivers for this. METHODS: In 2017, data were reviewed from an online postal STI kit requesting service at a time of transitioning from MT to DBS...
August 2, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30061192/diagnostic-performance-of-pcr-assays-for-the-diagnosis-of-neurosyphilis-a-systematic-review
#18
Michael Marks, David Lawrence, Christian Kositz, David Mabey
INTRODUCTION: Syphilis continues to be a major public health problem and the recent resurgence in syphilis in high-income settings has seen an accompanying increase in cases of neurosyphilis. While the introduction of PCR has had a significant impact on the diagnosis of early syphilis, cerebrospinal fluid (CSF) serological assays remain the most commonly used tests to diagnosis neurosyphilis. We reviewed data on the performance of CSF-PCR for the diagnosis of neurosyphilis. METHODS: We searched Pubmed, Medline, EMBASE and the grey literature for references on PCR in neurosyphilis...
July 30, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30032110/enhancing-hiv-prevention-and-care-among-men-who-have-sex-with-men-insights-from-social-psychology
#19
EDITORIAL
Rusi Jaspal, Matthew Page
No abstract text is available yet for this article.
July 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/30018088/inflammatory-cytokine-biomarkers-of-asymptomatic-sexually-transmitted-infections-and-vaginal-dysbiosis-a-multicentre-validation-study
#20
Lindi Masson, Shaun Barnabas, Jennifer Deese, Katie Lennard, Smritee Dabee, Hoyam Gamieldien, Shameem Z Jaumdally, Anna-Lise Williamson, Francesca Little, Lut Van Damme, Khatija Ahmed, Tania Crucitti, Saïd Abdellati, Linda-Gail Bekker, Glenda Gray, Janan Dietrich, Heather Jaspan, Jo-Ann S Passmore
OBJECTIVES: Vaginal dysbiosis and STIs are important drivers of the HIV epidemic and reproductive complications. These conditions remain prevalent, partly because most cases are asymptomatic. We have shown that inflammatory cytokines interleukin (IL)-1α, IL-1β and interferon-γ-induced protein (IP)-10 are biomarkers for detecting asymptomatic STIs and vaginal dysbiosis (bacterial vaginosis (BV) or intermediate microbiota). This study aimed to validate the performance of these biomarkers in African women recruited regardless of symptoms...
July 17, 2018: Sexually Transmitted Infections
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