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Sexually Transmitted Infections

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https://www.readbyqxmd.com/read/28798195/cross-sectional-study-to-evaluate-trichomonas-vaginalis-positivity-in-women-tested-for-neisseria-gonorrhoeae-and-chlamydia-trachomatis-attending-genitourinary-medicine-and-primary-care-clinics-in-bristol-south-west-england
#1
Jane E Nicholls, Katy M E Turner, Paul North, Ralph Ferguson, Margaret T May, Karen Gough, John Macleod, Peter Muir, Patrick J Horner
BACKGROUND: Highly sensitive, commercial nucleic acid amplification tests (NAAT) for Trichomonas vaginalis have only recently been recommended for use in the UK. While testing for T. vaginalis is routine in symptomatic women attending genitourinary medicine (GUM) clinics, it is rare in asymptomatic women or those attending primary care. The aim of this study was to evaluate the positivity of T. vaginalis using a commercial NAAT, in symptomatic and asymptomatic women undergoing testing for chlamydia and gonorrhoea in GUM and primary care settings...
August 10, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28784618/genetic-transmission-networks-reveal-the-transmission-patterns-of-hiv-1-crf01_ae-in-china
#2
Xiaoshan Li, Rong Gao, Kexin Zhu, Feiran Wei, Kun Fang, Wei Li, Yue Song, You Ge, Yu Ji, Ping Zhong, Pingmin Wei
OBJECTIVES: The epidemic of HIV-1 CRF01_AE has become a major public health issue in China. This study aimed to characterise the transmission patterns of genetic networks for CRF01_AE nationwide and elucidate possible opportunities for prevention. METHODS: We isolated and conducted genetic transmission network analysis of all available CRF01_AE pol sequences (n=4704) from China in the Los Alamos HIV sequence database. RESULTS: A total of 1391 (29...
August 7, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28778981/role-of-dual-hiv-syphilis-test-kits-in-expanding-syphilis-screening
#3
EDITORIAL
Melanie M Taylor, Rosanna W Peeling, Igor Toskin, Massimo Ghinidelli
No abstract text is available yet for this article.
August 4, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28778980/places-and-people-the-perceptions-of-men-who-have-sex-with-men-concerning-sti-testing-a-qualitative-study
#4
Jessica Datta, David Reid, Gwenda Hughes, Catherine H Mercer, Sonali Wayal, Peter Weatherburn
OBJECTIVES: To explore the experiences and views of men who have sex with men (MSM) on attending clinical sexual health services and their preferences regarding service characteristics in the context of the disproportionate burden of STIs experienced by this group. The wider study aim was to develop a risk assessment tool for use in sexual health clinics. METHODS: Qualitative study comprising eight focus group discussions with 61 MSM in four English cities. Topics included: experience of attending sexual health services, perceptions of norms of attendance among MSM, knowledge of, and attitudes towards, STIs and views on 'being researched...
August 4, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28778979/assessing-for-domestic-violence-in-sexual-health-environments-a-qualitative-study
#5
Jeremy Horwood, Andrew Morden, Jayne E Bailey, Neha Pathak, Gene Feder
OBJECTIVES: Domestic violence and abuse (DVA) is a major clinical challenge and public health issue. Sexual health services are an important potential site of DVA intervention. The Assessing for Domestic Violence in Sexual Health Environments (ADViSE) intervention aimed to improve identification and management of DVA in sexual healthcare settings and is a modified version of the Identification and Referral to Improve Safety (IRIS) general practice programme. Our qualitative evaluation aimed to explore the experiences of staff participating in an IRIS ADViSE pilot...
August 4, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28760772/correction-identifying-factors-that-lead-to-the-persistence-of-imported-gonorrhoeae-strains-a-modelling-study
#6
LETTER
(no author information available yet)
No abstract text is available yet for this article.
July 31, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28756409/female-and-younger-subjects-have-lower-adherence-in-prep-trials-a-meta-analysis-with-implications-for-the-uptake-of-prep-service-to-prevent-hiv
#7
REVIEW
Ke Yun, Jun-Jie Xu, Jing Zhang, Jia-Ming Li, Qing-Hai Hu, Zhen-Xing Chu, Yong-Jun Jiang, Wen-Qing Geng, Hong Shang, Ning Wang
OBJECTIVE: To estimate the medicine-taking compliance (MTC) level, explore its facilitators and barriers, and quantify the association between MTC level and pre-exposure prophylaxis (PrEP) protective efficacy in individuals at risk of acquiring HIV being administered oral PrEP. DESIGN: Meta-analysis. DATA SOURCES: We searched PubMed, Cochrane and Embase databases for published randomized controlled trials (RCTs) pertaining to MTC of oral PrEP for HIV prevention up to 16 January 2017...
July 29, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28747410/a-systematic-review-and-meta-analysis-of-studies-evaluating-the-performance-and-operational-characteristics-of-dual-point-of-care-tests-for-hiv-and-syphilis
#8
REVIEW
Harriet D Gliddon, Rosanna W Peeling, Mary L Kamb, Igor Toskin, Teodora E Wi, Melanie M Taylor
BACKGROUND: Mother-to-child transmission (MTCT) of syphilis and HIV continue to be important yet preventable causes of perinatal and infant morbidity and mortality. OBJECTIVES: To systematically review, critically appraise and perform a meta-analysis to evaluate the operational characteristics of dual rapid diagnostic tests (RDTs) for HIV/syphilis and evaluate whether they are cost effective, acceptable and easy to use. DESIGN: Systematic review and meta-analysis...
July 26, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28739808/experiences-of-hiv-postexposure-prophylaxis-pep-among-highly-exposed-men-who-have-sex-with-men-msm
#9
Romain Palich, Guillaume Martin-Blondel, Lise Cuzin, Jean-Yves Le Talec, Pierre Boyer, Patrice Massip, Pierre Delobel
OBJECTIVES: HIV postexposure prophylaxis (PEP) is indicated after sexual exposure with high risk of transmission. Men who have sex with men (MSM) are the main target of PEP. The aim of our study was to investigate the experience and shortcomings of PEP among people with a high risk of HIV exposure. DESIGN AND METHODS: Subjects with ongoing follow-up for HIV infection and PEP history were selected for the qualitative study. Semistructured interviews were conducted at the patients' homes...
July 24, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28724744/ten-years-transmission-of-the-new-variant-of-chlamydia-trachomatis-in-sweden-prevalence-of-infections-and-associated-complications
#10
Jenny Dahlberg, Ronza Hadad, Karin Elfving, Inger Larsson, Jenny Isaksson, Anders Magnuson, Hans Fredlund, Magnus Unemo, Bjőrn Herrmann
OBJECTIVES: In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications...
July 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28724743/improving-the-healthcare-response-to-domestic-violence-and-abuse-in-sexual-health-clinics-feasibility-study-of-a-training-support-and-referral-intervention
#11
Alex Hardip Sohal, Neha Pathak, Sarah Blake, Vanessa Apea, Judith Berry, Jayne Bailey, Chris Griffiths, Gene Feder
OBJECTIVES: Sexual health and gynaecological problems are the most consistent and largest physical health differences between abused and non-abused female populations. Sexual health services are well placed to identify and support patients experiencing domestic violence and abuse (DVA). Most sexual health professionals have had minimal DVA training despite English National Institute for Health and Care Excellence recommendations. We sought to determine the feasibility of an evidence-based complex DVA training intervention in female sexual health walk-in services (IRIS ADViSE: Identification and Referral to Improve Safety whilst Assessing Domestic Violence in Sexual Health Environments)...
July 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28717051/detection-of-markers-predictive-of-macrolide-and-fluoroquinolone-resistance-in-mycoplasma-genitalium-from-patients-attending-sexual-health-services-in-england
#12
Rachel Pitt, Helen Fifer, Neil Woodford, Sarah Alexander
OBJECTIVES: Resistance to both macrolides and fluoroquinolones has been reported in Mycoplasma genitalium; however, due to limited diagnostics, studies are often small and confined to specific geographical areas. This study sought to determine the rate of predicted resistance in M. genitalium-positive specimens referred for diagnostic testing. METHODS: Seventy-four M. genitalium-positive specimens, referred to the national reference laboratory (2010-2013) from 19 centres across England, were blinded and anonymised...
July 17, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28717050/which-azithromycin-regimen-should-be-used-for-treating-mycoplasma-genitalium-a-meta-analysis
#13
REVIEW
Patrick Horner, Suzanne M Ingle, Frederick Garrett, Karla Blee, Fabian Kong, Peter Muir, Harald Moi
BACKGROUND: There is increasing evidence that azithromycin 1 g is driving the emergence of macrolide resistance in Mycoplasma genitalium worldwide. We undertook a meta-analysis of M. genitalium treatment studies using azithromycin 1 g single dose and azithromycin 500 mg on day 1 then 250 mg daily for 4 days (5-day regimen) to determine rates of treatment failure and resistance in both regimens. METHODS: The online databases PubMed and Medline were searched using terms "Mycoplasma genitalium", "macrolide" or "azithromycin" and "resistance" up to April 2016...
July 17, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28705938/can-enhanced-screening-of-men-with-a-history-of-prior-syphilis-infection-stem-the-epidemic-in-men-who-have-sex-with-men-a-mathematical-modelling-study
#14
Ashleigh R Tuite, Souradet Shaw, Joss N Reimer, Craig P Ross, David N Fisman, Sharmistha Mishra
OBJECTIVES: The aim of this study is to determine the transmission impact of using prior syphilis infection to guide a focused syphilis screening intervention among men who have sex with men (MSM). METHODS: We parameterised a deterministic model of syphilis transmission in MSM to reflect the 2011-2015 syphilis outbreak in Winnipeg, Canada. Enhanced screening of 75% of men with prior syphilis every 3 months (A) was compared with distributing equivalent number tests to all MSM (B) or those with the highest partner number (C)...
July 13, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28698211/extra-rectal-lymphogranuloma-venereum-in-france-a-clinical-and-molecular-study
#15
Arnaud Desclaux, Arabella Touati, Didier Neau, Cécile Laurier-Nadalié, Cécile Bébéar, Bertille de Barbeyrac, Charles Cazanave
OBJECTIVES: To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France. METHODS: Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete ompA gene sequence of our samples was determined. RESULTS: There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV...
July 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28684611/rapid-and-point-of-care-tests-for-the-diagnosis-of-trichomonas-vaginalis-in-women-and-men
#16
Charlotte A Gaydos, Jeffrey D Klausner, Nitika Pant Pai, Helen Kelly, Cordelia Coltart, Rosanna W Peeling
BACKGROUND: Trichomonasvaginalis (TV) is a highly prevalent parasitic infection worldwide. It is associated with many adverse reproductive health outcomes. Many infections are asymptomatic and syndromic management leads to underdetection of TV. Traditional methods of TV detection such as wet preparation are insensitive. New rapid, point-of-care (POC) tests can enhance the diagnosis of trichomoniasis. METHODS: The authors reviewed the literature and discuss older POC tests for TV detection, as well as the OSOM lateral flow test, the AmpliVue test, the Solana test and the GeneXpert test as well as the limitations of wet preparation and culture for detection of TV...
July 6, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28684610/rapid-accurate-point-of-care-tests-combining-diagnostics-and-antimicrobial-resistance-prediction-for-neisseria-gonorrhoeae-and-mycoplasma-genitalium
#17
Syed Tariq Sadiq, Fulvia Mazzaferri, Magnus Unemo
In addition to inadequate access to early diagnosis and treatment with antimicrobial agents for patients and sexual contacts, management and control of STIs is significantly challenged by emergence and spread of antimicrobial resistance (AMR), particularly for STIs such as Neisseria gonorrhoeae and Mycoplasma genitalium This is further compounded by use of nucleic acid amplification techniques for diagnosis, resulting in reduced phenotypic AMR testing for N. gonorrhoeae and absence or suboptimal AMR surveillance for guiding treatment of both STIs in many settings...
July 6, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28679630/condomless-sex-in-hiv-diagnosed-men-who-have-sex-with-men-in-the-uk-prevalence-correlates-and-implications-for-hiv-transmission
#18
Marina Daskalopoulou, Alison J Rodger, Andrew N Phillips, Lorraine Sherr, Jonathan Elford, Jeffrey McDonnell, Simon Edwards, Nicky Perry, Ed Wilkins, Simon Collins, Anne M Johnson, William J Burman, Andrew Speakman, Fiona C Lampe
OBJECTIVE: HIV transmission is ongoing among men who have sex with men (MSM) in the UK. Sex without a condom (condomless sex, CLS) is the main risk factor. We investigated the prevalence of and factors associated with types of CLS. METHODS: Cross-sectional questionnaire study in UK HIV clinics in 2011/2012 (ASTRA). MSM diagnosed with HIV for ≥3 months reported on anal and vaginal sex, CLS with HIV-serodifferent partners (CLS-D) and CLS with HIV-seroconcordant (CLS-C) partners in the previous 3 months...
July 5, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28676558/willingness-to-change-behaviours-to-reduce-the-risk-of-pharyngeal-gonorrhoea-transmission-and-acquisition-in-men-who-have-sex-with-men-a-cross-sectional-survey
#19
Eric Pf Chow, Sandra Walker, Tiffany Phillips, Christopher K Fairley
OBJECTIVES: The aim of this study was to examine the willingness of men who have sex with men (MSM) to change their behaviours to potentially reduce the risk of pharyngeal gonorrhoea transmission and acquisition. METHODS: A cross-sectional questionnaire-based study was conducted among MSM attending the Melbourne Sexual Health Centre, Australia, between March and September 2015. Participants were asked how likely they would change their behaviours to reduce the risk of pharyngeal gonorrhoea...
July 4, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28637906/anogenital-warts-and-other-hpv-associated-anogenital-lesions-in-the-hiv-positive-patient-a-systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-interventions-assessed-in-controlled-clinical-trials
#20
Ricardo Niklas Werner, Lukas Westfechtel, Corinna Dressler, Alexander Nast
OBJECTIVES: Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised and HIV-positive patients carry the highest epidemiological burden of human papillomavirus (HPV) infection and comprise a population specifically susceptible to treatment failures and recurrences. This systematic review aimed at identifying and appraising the available evidence from controlled studies of interventions for the treatment of AGW and IEN in immunocompromised patients...
June 21, 2017: Sexually Transmitted Infections
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