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Toxicological Sciences: An Official Journal of the Society of Toxicology

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https://www.readbyqxmd.com/read/28206647/fasiglifam-tak-875-mechanistic-investigation-and-retrospective-identification-of-hazards-for-drug-induced-liver-injury-dili
#1
Monicah A Otieno, Jan Snoeys, Wing Lam, Avi Ghosh, Mark R Player, Alessandro Pocai, Rhys Salter, Damir Simic, Hollie Skaggs, Bhanu Singh, Lim Heng-Keang
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28206646/acute-melamine-affects-spatial-memory-consolidation-via-inhibiting-hippocampal-nmdar-dependent-ltd-in-rats
#2
Lei An, Wei Sun
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28206643/in-vivo-exposure-to-inorganic-arsenic-alters-differentiation-specific-gene-expression-of-adipose-derived-mesenchymal-stem-stromal-cells-in-c57bl-6j-mouse-model
#3
Joseph J Shearer, Manoel Figueiredo Neto, C Samuel Umbaugh, Marxa L Figueiredo
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28204799/epalrestat-stimulated-oxidative-stress-inflammation-and-fibrogenesis-in-mouse-liver
#4
Yuan Le, Liming Chen, Yue Zhang, Pengli Bu, Guoli Dai, Xingguo Cheng
No abstract text is available yet for this article.
February 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201627/in-utero-exposure-to-gadolinium-and-adverse-neonatal-outcomes-in-premature-infants
#5
Radhika Amin, Thomas Darrah, Hongyue Wang, Sanjiv Amin
No abstract text is available yet for this article.
February 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201809/newborn-mice-lacking-the-gene-for-cyp1a1-are-more-susceptible-to-oxygen-mediated-lung-injury-and-are-rescued-by-postnatal-%C3%AE-napthoflavone-bnf-administration-implications-for-bronchopulmonary-dysplasia-bpd-in-premature-infants
#6
Paramahamsa Maturu, Yanhong Wei-Liang, Weiwu Jiang, Lihua Wang, Krithika Lingappan, Roberto Barrios, Yao Liang, Bhagavatula Moorthy, Xanthi I Couroucli
No abstract text is available yet for this article.
February 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201806/derivation-and-evaluation-of-putative-adverse-outcome-pathways-for-the-effects-of-cyclooxygenase-inhibitors-on-reproductive-processes-in-female-fish
#7
Dalma Martinović-Weigelt, Alvine C Mehinto, Gerald T Ankley, Jason P Berninger, Timothy W Collette, John M Davis, Nancy D Denslow, Elizabeth J Durhan, Evan Eid, Drew R Ekman, Kathleen M Jensen, Mike D Kahl, Carlie A LaLone, Quincy Teng, Daniel L Villeneuve
No abstract text is available yet for this article.
February 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28186253/mechanistic-investigations-into-the-developmental-toxicity-of-nitrated-and-heterocyclic-pahs
#8
Anna C Chlebowski, Gloria R Garcia, Jane K La Du, William H Bisson, Lisa Truong, Staci L Massey Simonich, Robert L Tanguay
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184909/activation-of-nf-%C3%AE%C2%BAb-autophagy-axis-by-2-hydroxyethyl-methacrylate-commits-dental-mesenchymal-cells-to-apoptosis
#9
Jing-Jing Yu, Ling-Xin Zhu, Jie Zhang, Shan Liu, Feng-Yuan Lv, Xue Cheng, Guo-Jing Liu, Bin Peng
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184907/regulation-of-nitrogen-mustard-induced-lung-macrophage-activation-by-valproic-acid-a-histone-deacetylase-inhibitor
#10
Alessandro Venosa, James G Gow, Leroy Hall, Rama Malaviya, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184906/exposure-based-validation-of-an-in-vitro-gastrulation-model-for-developmental-toxicity-assays
#11
Erica L L Warkus, Yusuke Marikawa
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184905/glutathione-s-transferase-activity-moderates-methylmercury-toxicity-during-development-in-drosophila
#12
Daria Vorojeikina, Karin Broberg, Tanzy M Love, Philip W Davidson, Edwin van Wijngaarden, Matthew D Rand
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184904/periodic-exposure-to-smartphone-mimic-low-luminance-blue-light-induces-retina-damage-through-bcl-2-bax-dependent-apoptosis
#13
Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28123103/embryonic-exposure-to-the-environmental-neurotoxin-bmaa-negatively-impacts-early-neuronal-development-and-progression-of-neurodegeneration-in-the-sod1-g93r-zebrafish-model-of-amyotrophic-lateral-sclerosis
#14
Samantha Powers, Samantha Kwok, Emily Lovejoy, Tom Lavin, Roger Sher
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder leading to progressive paralysis and death within 2-5 years after diagnosis. Sporadic cases (SALS) comprise ∼90% of cases with the remaining 10% familial (FALS) caused by mutations in ∼27 genes. The vast heterogeneity seen in age and location of disease onset, rate of progression, and duration of disease have been linked with genetic and environmental influences in both SALS and FALS cases. Increased ALS incidence clusters in Guam, southern France, and Maryland have been linked with exposure to Beta-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by cyanobacteria, dinoflaggelates, and diatoms...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28123102/the-minipig-is-a-suitable-non-rodent-model-in-the-safety-assessment-of-single-stranded-oligonucleotides
#15
A Braendli-Baiocco, M Festag, K Dumong-Erichsen, R Persson, M J Mihatsch, N Fisker, J Funk, S Mohr, R Constien, C Ploix, K Brady, M Berrera, B Altmann, B Lenz, M Albassam, G Schmitt, T Weiser, F Schuler, T Singer, Y Tessier
Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safety of this class of compounds. Four different phosphorothioated locked nucleic acid (LNA)-based SSOs (three antisense and one anti-miR), all with known safety profiles, were administered to minipigs using similar study designs and read-outs as in earlier NHP studies with the same compounds...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28123101/application-of-gene-set-enrichment-analysis-for-identification-of-chemically-induced-biologically-relevant-transcriptomic-networks-and-potential-utilization-in-human-health-risk-assessment
#16
Jeffry L Dean, Q Jay Zhao, Jason C Lambert, Belinda S Hawkins, Russell S Thomas, Scott C Wesselkamper
The rate of new chemical development in commerce combined with a paucity of toxicity data for legacy chemicals presents a unique challenge for human health risk assessment. There is a clear need to develop new technologies and incorporate novel data streams to more efficiently inform derivation of toxicity values. One avenue of exploitation lies in the field of transcriptomics and the application of gene expression analysis to characterize biological responses to chemical exposures. In this context, Gene Set Enrichment Analysis (GSEA) was employed to evaluate tissue-specific, dose-response gene expression data generated following exposure to multiple chemicals for various durations...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28123100/hepatic-detoxification-of-bisphenol-a-is-retinoid-dependent
#17
Igor O Shmarakov, Vira L Borschovetska, William S Blaner
Bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl) propane) is a widely used industrial chemical. The extensive distribution of BPA in the environment poses risks to humans however the molecular mechanisms underlying BPA toxicity as well as its effective detoxification and elimination are not well understood. We have investigated specifically for BPA the notion raised in the literature that the optimal sensing, detoxification and elimination of xenobiotics requires retinoid (natural derivatives and synthetic analogs of vitamin A) actions...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28123099/teratogenic-effects-of-in-utero-exposure-to-di-2-ethylhexyl-phthalate-dehp-in-b6-129s4-mice
#18
Erica Ungewitter, Emmi Rotgers, Tanika Bantukul, Yasuhiko Kawakami, Grace E Kissling, Humphrey Hung-Chang Yao
Intrauterine exposure to phthalates is known to cause disorders of male reproductive function including androgen insufficiency, decreased fertility, and germ cell defects in rodents. In this study, we set out to investigate the effects of intrauterine exposure to di-(2-ethylhexyl)-phthalate (DEHP) on fetal development of the B6:129S4 mouse strain. Time-mated pregnant C57BL/6 dams were exposed to 0, 5, 250, or 500 mg/kg DEHP with corn oil as the vehicle via oral gavage from embryonic days (E)7 to 16. Survival and gross morphology of the pups were analyzed one day after the last treatment...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28175884/ion-shedding-zinc-oxide-nanoparticles-induce-microglial-bv2-cell-proliferation-via-the-erk-and-akt-signaling-pathways
#19
Jia Liu, Yiyuan Kang, Wei Zheng, Bin Song, Limin Wei, Liangjiao Chen, Longquan Shao
No abstract text is available yet for this article.
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28115655/assessment-of-dna-chromosome-damage-in-the-peripheral-blood-lymphocytes-of-workers-exposed-to-indium-compounds
#20
Nan Liu, Yi Guan, Ling Xue, Yan Yu, Jingwei Xiao, Zhimin Chang, Qingzhao Li, Yuping Bai, Bin Li, Weijun Guan
This study was conducted to investigate possible genotoxic effects resulting from occupational exposure to indium compounds. We performed a cytogenetic analysis of peripheral blood lymphocytes gathered from 57 individuals exposed to indium at an indium ingot production plant in Guangxi, China, and compared the results with those obtained from 63 control subjects. The lymphocytes from both groups were examined in the chromosomal aberrations (CAs) assay, cytokinesis-block micronucleus (CBMN) assay, and single-cell gel electrophoresis (comet) assay...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
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