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Toxicological Sciences: An Official Journal of the Society of Toxicology

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https://www.readbyqxmd.com/read/28329872/doxorubicin-has-dose-dependent-toxicity-on-mouse-ovarian-follicle-development-hormone-secretion-and-oocyte-maturation
#1
Shuo Xiao, Jiyang Zhang, Mingjun Liu, Hideyuki Iwahata, Hunter B Rogers, Teresa K Woodruff
Doxorubicin (DOX), one of the most commonly used anticancer medications, has been reported to affect fertility by damaging ovarian follicles; however, the dose-dependent toxicity of DOX on the dynamic follicle development and oocyte maturation has not been well-defined. Our objective is to determine the effects of human-relevant exposure levels of DOX on follicular functions across developmental time. In vitro cultured multilayered secondary mouse follicles were treated with DOX at 0, 2, 20, 100, and 200 nM for 24 hours, and follicle development, hormone secretion, and oocyte maturation were analyzed...
March 17, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329845/spatiotemporal-progression-and-remission-of-lesions-in-the-rat-brain-following-acute-intoxication-with-diisopropylfluorophosphate
#2
Sílvia Sisó, Brad A Hobson, Danielle J Harvey, Donald A Bruun, Douglas J Rowland, Joel R Garbow, Pamela J Lein
Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). However, in contrast to the OP nerve agents, the long-term consequences of DFP-induced SE are not well known. Thus, we characterized the spatiotemporal profile of neuropathology during the first two months following acute DFP intoxication. Adult, male Sprague Dawley rats administered pyridostigmine bromide (0...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329842/magnetic-resonance-imaging-reveals-progressive-brain-injury-in-rats-acutely-intoxicated-with-diisopropylfluorophosphate
#3
Brad A Hobson, Sílvia Sisó, Douglas J Rowland, Danielle J Harvey, Donald A Bruun, Joel R Garbow, Pamela J Lein
Acute intoxication with organophosphates (OPs) can trigger seizures that progress to status epilepticus, and survivors often exhibit chronic neuropathology, cognitive impairment, affective disorders and/or electroencephalographic abnormalities. Understanding how acute injury transitions to persistent neurological sequelae is critical to developing medical countermeasures for mitigating damage following OP-induced seizures. Here, we used in vivo magnetic resonance imaging (MRI) to monitor the spatiotemporal patterns of neuropathology for one month after acute intoxication with diisopropylfluorophosphate (DFP)...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329870/application-of-imaging-techniques-to-cases-of-drug-induced-crystal-nephropathy-in-preclinical-studies
#4
B Lenz, A Brink, M Siam, A De Paepe, S Bassett, A Eichinger-Chapelon, P Maliver, R Neff, U Niederhauser, B Steinhuber, R Zurbach, T Singer, C Funk, F Schuler, M Albassam, S Schadt
A number of drugs can cause precipitates within renal tubules leading to crystal nephropathy. Crystal nephropathy is usually an exposure-related finding and is not uncommon in preclinical studies, where high doses are tested. An understanding of the nature of precipitates is important for human risk assessment and further development. Our aim was to investigate the ability of various imaging techniques to detect the presence of drugs or metabolites in renal crystals. We applied matrix-assisted laser desorption/ionization - Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) imaging, Raman and infrared microspectroscopy, scanning electron microscopy coupled with energy dispersive X-ray (SEM/EDX) spectroscopy and standard histopathology to cases of drug-induced crystal nephropathy, induced in rodents and primates by four compounds...
February 27, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329862/the-transcriptome-of-the-zebrafish-embryo-after-chemical-exposure-a-meta-analysis
#5
Andreas Schüttler, Kristin Reiche, Rolf Altenburger, Wibke Busch
Numerous studies have been published in the past years investigating the transcriptome of the zebrafish embryo (ZFE) upon being subjected to chemical stress. Aiming at a more mechanistic understanding of the results of such studies, knowledge about commonalities of transcript regulation in response to chemical stress is needed. Thus, our goal in this study was to identify and interpret genes and gene sets constituting a general response to chemical exposure. Therefore, we aggregated and reanalyzed published toxicogenomics data obtained with the ZFE...
February 27, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329851/short-tslp-attenuates-toluene-diisocyanate-tdi-induced-airway-inflammation-and-inhibits-hmgb1-rage-and-long-tslp-expression
#6
Yanhong Wang, Yanqing Le, Wenqu Zhao, Yun Lin, Yue Wu, Changhui Yu, Jing Xiong, Fei Zou, Hangming Dong, Shaoxi Cai, Haijin Zhao
Short thymic stromal lymphopoietin (short TSLP), one of TSLP variants, exerts anti-inflammatory activities in endotoxin shock and colitis mouse models. Our latest work reported that short TSLP prevented house dust mite (HDM)-induced epithelial barrier disruption. Yet the role of short TSLP in toluene diisocyanate (TDI)-induced asthma is unknown. Male BALB/c mice were sensitized and challenged with TDI to generate a chemical-induced asthma model. Synthetic short TSLP peptides were given intranasally (i.n.) or intraperitoneally (i...
February 27, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329833/thy1-cd90-expression-is-reduced-by-the-environmental-chemical-tetrabromobisphenol-a-to-promote-adipogenesis-through-induction-of-microrna-103
#7
Collynn F Woeller, E'Lissa Flores, Stephen J Pollock, Richard P Phipps
Environmental chemicals termed "obesogens" disrupt the endocrine system to promote adipogenesis and obesity. Tetrabromobisphenol-A (TBBPA) has been reported to increase adipogenesis, however, the mechanism(s) of action are unclear. Thy1 (CD90) is a glycophosphatidylinositol (GPI) -anchored membrane protein that serves as a marker for stem cells and also plays an important role in regulating adipogenesis and obesity. We investigated whether or not TBBPA promotes adipogenesis in human and mouse cells by reducing Thy1 levels...
February 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28206647/fasiglifam-tak-875-mechanistic-investigation-and-retrospective-identification-of-hazards-for-drug-induced-liver-injury-dili
#8
Monicah A Otieno, Jan Snoeys, Wing Lam, Avi Ghosh, Mark R Player, Alessandro Pocai, Rhys Salter, Damir Simic, Hollie Skaggs, Bhanu Singh, Lim Heng-Keang
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28206646/acute-melamine-affects-spatial-memory-consolidation-via-inhibiting-hippocampal-nmdar-dependent-ltd-in-rats
#9
Lei An, Wei Sun
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28206643/in-vivo-exposure-to-inorganic-arsenic-alters-differentiation-specific-gene-expression-of-adipose-derived-mesenchymal-stem-stromal-cells-in-c57bl-6j-mouse-model
#10
Joseph J Shearer, Manoel Figueiredo Neto, C Samuel Umbaugh, Marxa L Figueiredo
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28204799/epalrestat-stimulated-oxidative-stress-inflammation-and-fibrogenesis-in-mouse-liver
#11
Yuan Le, Liming Chen, Yue Zhang, Pengli Bu, Guoli Dai, Xingguo Cheng
No abstract text is available yet for this article.
February 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201627/in-utero-exposure-to-gadolinium-and-adverse-neonatal-outcomes-in-premature-infants
#12
Radhika Amin, Thomas Darrah, Hongyue Wang, Sanjiv Amin
No abstract text is available yet for this article.
February 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201809/newborn-mice-lacking-the-gene-for-cyp1a1-are-more-susceptible-to-oxygen-mediated-lung-injury-and-are-rescued-by-postnatal-%C3%AE-napthoflavone-bnf-administration-implications-for-bronchopulmonary-dysplasia-bpd-in-premature-infants
#13
Paramahamsa Maturu, Yanhong Wei-Liang, Weiwu Jiang, Lihua Wang, Krithika Lingappan, Roberto Barrios, Yao Liang, Bhagavatula Moorthy, Xanthi I Couroucli
No abstract text is available yet for this article.
February 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28201806/derivation-and-evaluation-of-putative-adverse-outcome-pathways-for-the-effects-of-cyclooxygenase-inhibitors-on-reproductive-processes-in-female-fish
#14
Dalma Martinović-Weigelt, Alvine C Mehinto, Gerald T Ankley, Jason P Berninger, Timothy W Collette, John M Davis, Nancy D Denslow, Elizabeth J Durhan, Evan Eid, Drew R Ekman, Kathleen M Jensen, Mike D Kahl, Carlie A LaLone, Quincy Teng, Daniel L Villeneuve
No abstract text is available yet for this article.
February 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28186253/mechanistic-investigations-into-the-developmental-toxicity-of-nitrated-and-heterocyclic-pahs
#15
Anna C Chlebowski, Gloria R Garcia, Jane K La Du, William H Bisson, Lisa Truong, Staci L Massey Simonich, Robert L Tanguay
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184909/activation-of-nf-%C3%AE%C2%BAb-autophagy-axis-by-2-hydroxyethyl-methacrylate-commits-dental-mesenchymal-cells-to-apoptosis
#16
Jing-Jing Yu, Ling-Xin Zhu, Jie Zhang, Shan Liu, Feng-Yuan Lv, Xue Cheng, Guo-Jing Liu, Bin Peng
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184907/regulation-of-nitrogen-mustard-induced-lung-macrophage-activation-by-valproic-acid-a-histone-deacetylase-inhibitor
#17
Alessandro Venosa, James G Gow, Leroy Hall, Rama Malaviya, Andrew J Gow, Jeffrey D Laskin, Debra L Laskin
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184906/exposure-based-validation-of-an-in-vitro-gastrulation-model-for-developmental-toxicity-assays
#18
Erica L L Warkus, Yusuke Marikawa
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184905/glutathione-s-transferase-activity-moderates-methylmercury-toxicity-during-development-in-drosophila
#19
Daria Vorojeikina, Karin Broberg, Tanzy M Love, Philip W Davidson, Edwin van Wijngaarden, Matthew D Rand
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28184904/periodic-exposure-to-smartphone-mimic-low-luminance-blue-light-induces-retina-damage-through-bcl-2-bax-dependent-apoptosis
#20
Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng
No abstract text is available yet for this article.
February 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
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