journal
https://read.qxmd.com/read/38403529/simulation-of-the-effects-of-molecular-urine-markers-in-follow-up-of-patients-with-high-risk-non-muscle-invasive-bladder-cancer
#21
REVIEW
Natalya Benderska-Söder, Thorsten Ecke, Lisa Kleinlein, Florian Roghmann, Ekkehardt Bismarck, Bas W G van Rhijn, Arnulf Stenzl, Johannes Alfred Witjes, Tilman Todenhöfer, Oliver W Hakenberg, Marc Oliver Grimm, Peter J Goebell, Maximilian Burger, Jorgen Bjerggaard Jensen, Bernd J Schmitz-Dräger
A plethora of urine markers for the management of patients with bladder cancer has been developed and studied in the past. However, the clinical impact of urine testing on patient management remains obscure. The goal of this manuscript is to identify scenarios for the potential use of molecular urine markers in the follow-up of patients with high-risk non-muscle-invasive BC (NMIBC) and estimate potential risks and benefits. Information on the course of disease of patients with high-risk NMIBC and performance data of a point-of-care test (UBC rapid™), an MCM-5 directed ELISA (ADXBLADDER™), and 2 additional novel assays targeting alterations of mRNA expression and DNA methylation (Xpert bladder cancer monitor™, Epicheck™) were retrieved from high-quality trials and/or meta-analyses...
February 24, 2024: Urologic Oncology
https://read.qxmd.com/read/38388245/reply-to-shun-fa-hung-s-letter-to-the-editor-regarding-the-article-clinical-impact-of-detrusor-muscle-in-en-bloc-resection-for-t1-bladder-cancer
#22
LETTER
Takafumi Yanagisawa, Jun Miki, Shun Sato, Hiroyuki Takahashi, Shahrokh F Shariat, Takahiro Kimura
No abstract text is available yet for this article.
February 21, 2024: Urologic Oncology
https://read.qxmd.com/read/38388244/robotic-or-open-superficial-inguinal-lymph-node-dissection-as-staging-procedures-for-clinically-node-negative-high-risk-penile-cancer
#23
JOURNAL ARTICLE
Manuel Ozambela, Barrett Z McCormick, Jan K Rudzinski, Alberto C Pieretti, Graciela M Nogueras González, Matthew A Meissner, John N Papadopoulos, Mehrad Adibi, Surena F Matin, Aaron S Dahmen, Philippe E Spiess, Curtis A Pettaway
OBJECTIVE: To evaluate perioperative and oncologic outcomes of a cohort of clinically node negative high-risk penile cancer patients undergoing robotic assisted inguinal lymph node dissection (RAIL) compared to patients undergoing open superficial inguinal lymph node dissection (OSILND). PATIENTS AND METHODS: We retrospectively reviewed the clinical characteristics and outcomes of clinically node negative high-risk penile cancer patients undergoing RAIL at MDACC from 2013-2019...
February 21, 2024: Urologic Oncology
https://read.qxmd.com/read/38388243/deep-learning-model-for-the-detection-of-prostate-cancer-and-classification-of-clinically-significant-disease-using-multiparametric-mri-in-comparison-to-pi-rads-score
#24
JOURNAL ARTICLE
Chunguang Yang, Basen Li, Yang Luan, Shiwei Wang, Yang Bian, Junbiao Zhang, Zefeng Wang, Bo Liu, Xin Chen, Marcus Hacker, Zhen Li, Xiang Li, Zhihua Wang
BACKGROUND: The Prostate Imaging Reporting and Data System (PI-RADS) is an established reporting scheme for multiparametric magnetic resonance imaging (mpMRI) to distinguish clinically significant prostate cancer (csPCa). Deep learning (DL) holds great potential for automating csPCa classification on mpMRI. METHOD: To compare the performance between a DL algorithm and PI-RADS categorization in PCa detection and csPCa classification, we included 1,729 consecutive patients who underwent radical prostatectomy or biopsy in Tongji hospital...
February 21, 2024: Urologic Oncology
https://read.qxmd.com/read/38383241/natural-history-of-bone-only-metastasis-in-renal-cell-carcinoma
#25
JOURNAL ARTICLE
Bixia Tang, Rong Duan, Zenan Fan, Xieqiao Yan, Siming Li, Li Zhou, Juan Li, Huayan Xu, Lili Mao, Bin Lian, Xuan Wang, Xue Bai, Xiaoting Wei, Caili Li, Chuanliang Cui, Lu Si, Zhihong Chi, Jun Guo, Xinan Sheng
BACKGROUND: Bone metastasis (BM) is considered a poor prognostic factor of renal cell carcinoma (RCC). Confusion exists regarding how to deal with RCC patients with bone-only metastasis. PATIENTS AND METHODS: The clinical data of consecutive RCC patients with bone-only metastasis at Peking University Cancer Hospital between 2006 and 2018 were retrospectively collected and analyzed. RESULTS: Fifty-four eligible patients were screened from an RCC database of 1,878 metastatic patients...
February 20, 2024: Urologic Oncology
https://read.qxmd.com/read/38383240/blood-based-liquid-biopsy-a-promising-noninvasive-test-in-diagnosis-surveillance-and-prognosis-of-patients-with-upper-tract-urothelial-carcinoma
#26
JOURNAL ARTICLE
Alireza Ghoreifi, Stephanie N Shishido, Salmaan Sayeed, George Courcoubetis, Amy Huang, Anne Schuckman, Monish Aron, Mihir Desai, Siamak Daneshmand, Inderbir S Gill, Peter Kuhn, Hooman Djaladat, Jeremy Mason
OBJECTIVES: To assess the efficacy of blood-based liquid biopsy in the diagnosis, surveillance, and prognosis of upper tract urothelial carcinoma (UTUC). METHODS AND MATERIALS: In this prospective study, peripheral blood samples were collected from patients with primary UTUC before surgery with curative intent and follow-up visits at University of Southern California between May 2021 and September 2022. The samples were analyzed using the third-generation comprehensive high-definition single-cell assay (HDSCA3...
February 20, 2024: Urologic Oncology
https://read.qxmd.com/read/38369443/symptomatic-and-functional-recovery-after-transurethral-resection-of-bladder-tumor-data-from-ecological-momentary-symptom-assessment
#27
JOURNAL ARTICLE
Marshall Strother, Ryan Barlotta, Robert Uzzo, Evan Bloom, Seyed B Jazayeri, Alberto C Bigalli, Jared Schober, Jennifer Lee, Adrien Bernstein, Kevin Ginsburg, Elizabeth Handorf, David Yt Chen, Andres Correa, Richard Greenberg, Marc Smaldone, Rosalia Viterbo, Alexander Kutikov
OBJECTIVES: To quantitatively describe the nature, severity, and duration of symptoms and functional impairment during recovery from transurethral resection of bladder tumors. MATERIALS AND METHODS: All patients scheduled for transurethral resection were approached for enrollment in a text-message based ecological momentary symptom assessment platform. Nine patients reported outcomes were measured 7 days before surgery and on postoperative days 1, 2, 3, 5, 7, 10, and 14 using a 5-point Likert scale...
February 17, 2024: Urologic Oncology
https://read.qxmd.com/read/38365461/annual-mpmri-surveillance-pi-rads-upgrading-and-increasing-trend-correlated-with-patients-who-harbor-clinically-significant-disease
#28
JOURNAL ARTICLE
Jacob W Greenberg, Christopher R Koller, Christine Lightfoot, Garrett J Brinkley, Gabriel Leinwand, Julie Wang, L Spencer Krane
INTRODUCTION: Prostate cancer screening has routinely identified men with very low- or low-risk disease, per the National Comprehensive Cancer Network guidelines. Current literature has demonstrated that the most appropriate management strategy for these patients is active surveillance (AS). The mainstay of AS includes periodic biopsies and biannual prostate-specific antigen tests. However, multiparametric magnetic resonance imaging (mpMRI) is uniquely posed to improve patient surveillance...
February 15, 2024: Urologic Oncology
https://read.qxmd.com/read/38360519/primary-retroperitoneal-lymph-node-dissection-for-clinical-stage-ii-seminoma-a-systematic-review-and-meta-analysis-of-safety-and-oncological-effectiveness
#29
REVIEW
Mehdi Kardoust Parizi, Vitaly Margulis, Aditya Bagrodia, Kensuke Bekku, Jakob Klemm, Akihiro Matsukawa, Arman Alimohammadi, Reza Sari Motlagh, Hadi Mostafaei, Ekaterina Laukhtina, Shahrokh F Shariat
To evaluate the oncological outcomes and safety of primary retroperitoneal lymph node dissection (RPLND) in patients with clinical stage (CS) II seminomatous testicular germ cell tumor (TGCT). A literature search using PubMed, Scopus, and Cochrane Library was conducted on July 2023 to identify relevant studies according to the Preferred Reporting Items for Systematic Review and Meta Analysis (PRISMA) guidelines. The pooled recurrence rate and treatment-related complications were calculated using a random effects model...
February 14, 2024: Urologic Oncology
https://read.qxmd.com/read/38355354/can-nomograms-accurately-predict-lymph-node-metastasis-in-high-risk-prostate-cancer-patients-receiving-definitive-radiotherapy-in-the-psma-pet-ct-era-time-to-burry-the-hatchet
#30
LETTER
Cem Onal, Aysenur Elmali, Ozan Cem Guler
No abstract text is available yet for this article.
February 13, 2024: Urologic Oncology
https://read.qxmd.com/read/38355353/prognostic-significance-of-pt3a-staging-subclassifications-in-renal-cell-carcinoma-not-all-pt3a-are-equal
#31
JOURNAL ARTICLE
Michael E Rezaee, Maximilian Pallauf, Sean A Fletcher, Christian P Pavlovich, Ezra Baraban, Yasser Ged, Nirmish Singla
OBJECTIVE: To examine the prognostic significance of perinephric fat, renal sinus fat, and renal vein invasion in patients with pT3a renal cell carcinoma (RCC) by histologic type. METHODS: A population-based retrospective cohort study of patients with pT3aN0M0 RCC was performed using Surveillance, Epidemiology, and End Results (SEER) data for the years 2010 through 2019. Cox proportional hazards models were used to examine the relationship between pT3a subclassification groups and cancer-specific survival (CSS) by histological subtype (clear cell, papillary, chromophobe, and other)...
February 13, 2024: Urologic Oncology
https://read.qxmd.com/read/38342654/reducing-the-demand-for-magnetic-resonance-imaging-scans-and-prostate-biopsies-during-the-early-detection-of-clinically-significant-prostate-cancer-applying-the-barcelona-risk-stratified-pathway-in-catalonia
#32
JOURNAL ARTICLE
Juan Morote, Ángel Borque-Fernando, Luis E Esteban, Natàlia Picola, Jesús Muñoz-Rodriguez, Nahuel Paesano, Xavier Ruiz-Plazas, Marta V Muñoz-Rivero, Anna Celma, Gemma García-de Manuel, Berta Miró, José M Abascal, Pol Servian
PURPOSE: To analyze the reduction in multiparametric magnetic resonance imaging (mpMRI) demand and prostate biopsies after the hypothetical implementation of the Barcelona risk-stratified pathway (BCN-RSP) in a population of the clinically significant prostate cancer (csCaP) early detection program in Catalonia. MATERIALS AND METHODS: A retrospective comparation between the hypothetical application of the BCN-RSP and the current pathway, which relied on pre-biopsy mpMRI and targeted and/or systematic biopsies, was conducted...
February 10, 2024: Urologic Oncology
https://read.qxmd.com/read/38341364/pathology-focused-review-of-morphologic-subtypes-and-molecular-variants-of-urothelial-carcinoma-with-an-emphasis-on-clinical-treatment-relevance
#33
REVIEW
Jonathon Mahlow, Sumati Gupta
Urothelial carcinoma (UC) has significant morbidity, mortality, and remains the most financially costly carcinoma to manage and treat. This review will cover special morphologic features of UC that may be noted by the pathologist and any subsequent significance in terms of clinical management or treatment considerations as mentioned or recommended in the latest WHO 2022 classification of GU tumors. Many important potentially therapy altering morphologic findings can be consistently identified and reported on routine microscopic examination of hematoxylin and eosin (H&E) stained slides...
February 9, 2024: Urologic Oncology
https://read.qxmd.com/read/38341363/serum-prolidase-activity-oxidative-stress-and-antioxidant-enzyme-levels-in-patients-with-prostate-cancer
#34
JOURNAL ARTICLE
Mehmet Kaba, Necip Pirincci, Halit Demir, Samed Verep
OBJECTIVES: We aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with prostate cancers and to evaluate their relationships with each other. MATERIALS AND METHODS: A total of 34 male patients with prostate cancer and with a mean age of 64.2 ± 4.4 were included in the study. The control group comprising 36 male patients (mean age 61.2 ± 3.4) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GPx), Catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20°C until they were used...
February 9, 2024: Urologic Oncology
https://read.qxmd.com/read/38341362/unraveling-the-bmi-paradox-in-different-renal-cortical-tumors-insights-from-the-inmarc-registry
#35
JOURNAL ARTICLE
Cesare Saitta, Jonathan A Afari, Arman Walia, Dattatraya Patil, Hajime Tanaka, Kevin Hakimi, Luke Wang, Margaret F Meagher, Franklin Liu, Mimi V Nguyen, Dhruv Puri, Clara Cerrato, Ava Saidian, Masaki Kobayashi, Shohei Fukuda, Yasuhisa Fujii, Viraj Master, Ithaar H Derweesh
OBJECTIVE: To investigate impact of body mass index (BMI) on survival across different histologies and stages of renal cell carcinoma (RCC). METHODS: We conducted a retrospective multicenter analysis of clear cell (ccRCC) and non-ccRCC. Obesity was defined according to the WHO criteria (non-Asian BMI >30 Kg/m2 , Asian BMI >27.5 Kg/m2 ). Multivariable analysis (MVA) via Cox regression model was conducted for all-cause (ACM), cancer-specific mortality (CSM) and recurrence...
February 9, 2024: Urologic Oncology
https://read.qxmd.com/read/38336499/regional-differences-in-upper-tract-urothelial-carcinoma-patients-across-the-united-states
#36
JOURNAL ARTICLE
Simone Morra, Lukas Scheipner, Andrea Baudo, Letizia Maria Ippolita Jannello, Mario de Angelis, Carolin Siech, Jordan A Goyal, Nawar Touma, Zhe Tian, Fred Saad, Gianluigi Califano, Roberto la Rocca, Marco Capece, Shahrokh F Shariat, Sascha Ahyai, Luca Carmignani, Ottavio de Cobelli, Gennaro Musi, Alberto Briganti, Felix K H Chun, Nicola Longo, Pierre I Karakiewicz
BACKGROUND: It is unknown whether regional differences in patient, tumor, and treatment characteristics of upper tract urothelial carcinoma (UTUC) patients exist and may potentially result in regional overall mortality (OM) differences. We tested for inter-regional differences, according to Surveillance, Epidemiology, and End Results (SEER) registries. METHODS: Using SEER database 2000 to 2016, patient (age, sex, race/ethnicity), tumor (location, grade) and treatment (nephroureterectomy, systemic therapy [ST]) characteristics of UTUC patients of all-stages were tabulated and graphically depicted in a stage-specific fashion (T1-2 N0 M0 vs...
February 8, 2024: Urologic Oncology
https://read.qxmd.com/read/38326213/re-clinical-impact-of-detrusor-muscle-in-en-bloc-resection-for-t1-bladder-cancer-yanagisawa-t-sato-s-hayashida-y-okada-y-fukuokaya-w-iwatani-k-et-al-j-urol-oncol-2023-41-12-484-e7-484-e15
#37
LETTER
https://read.qxmd.com/read/38320936/reply-to-khurshid-r-ghani-s-letter-to-editor-regarding-the-article-early-experience-with-ugn-101-for-the-treatment-of-upper-tract-urothelial-cancer-a-multicenter-evaluation-of-practice-patterns-and-outcomes
#38
LETTER
https://read.qxmd.com/read/38320935/unmarried-status-effect-on-stage-at-presentation-and-treatment-patterns-in-primary-urethral-carcinoma-patients
#39
JOURNAL ARTICLE
Simone Morra, Lukas Scheipner, Andrea Baudo, Letizia Maria Ippolita Jannello, Mario de Angelis, Carolin Siech, Jordan A Goyal, Nawar Touma, Zhe Tian, Fred Saad, Gianluigi Califano, Giuseppe Celentano, Roberto la Rocca, Luigi Napolitano, Shahrokh F Shariat, Sascha Ahyai, Luca Carmignani, Ottavio de Cobelli, Gennaro Musi, Alberto Briganti, Felix K H Chun, Nicola Longo, Pierre I Karakiewicz
BACKGROUND: Unmarried status has been associated with advanced stage at presentation and lower treatment dose intensification rates in several urological and non-urological malignancies. However, no previous investigators focused of the association of unmarried status with locally advanced stage (T3-4 N0-2 ) at presentation and lower bi-/trimodal therapy rates in primary urethral carcinoma (PUC) patients. To address these knowledge gaps, we relied on the Surveillance, Epidemiology, and End Results (SEER) database...
February 5, 2024: Urologic Oncology
https://read.qxmd.com/read/38320934/-published-abstracts-from-the-24th-annual-meeting-of-the-society-of-urologic-oncology
#40
EDITORIAL
Eric A Singer
No abstract text is available yet for this article.
February 5, 2024: Urologic Oncology
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