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Neuromodulation: Journal of the International Neuromodulation Society

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https://www.readbyqxmd.com/read/27898202/optimization-of-transcutaneous-vagus-nerve-stimulation-using-functional-mri
#1
Natalia Yakunina, Sam Soo Kim, Eui-Cheol Nam
OBJECTIVE/HYPOTHESIS: Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy, depression, and a number of other disorders. Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) has been considered as a non-invasive alternative. Several functional magnetic resonance imaging (fMRI) studies on the effects of tVNS used different stimulation parameters and locations in the ear, which makes it difficult to determine the optimal tVNS methodology...
November 29, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27873376/extended-long-term-effects-of-cervical-vagal-nerve-stimulation-on-headache-intensity-frequency-and-affective-cognitive-headache-perception-in-drug-resistant-complex-partial-seizure-patients
#2
Bogdan Pintea, Kevin Hampel, Jan Boström, Rainer Surges, Hartmut Vatter, Ilana S Lendvai, Thomas M Kinfe
OBJECTIVES: Invasive vagal nerve stimulation (iVNS) is an established treatment option for drug-resistant focal seizures and has been assumed to diminish frequent co-incidental daily headache/migraine. However, long-term effects on cognitive/affective head pain perception, headache intensity/frequency are lacking. We therefore investigated potential iVNS-induced effects in patients with drug-resistant focal seizure and daily headache/migraine. MATERIALS AND METHODS: A clinical database was used to select 325 patients with drug-resistant epilepsy treated by either iVNS plus best medical treatment (BMT) or BMT alone, compared to a healthy control group (HC)...
November 22, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27859948/peripheral-nerve-stimulation-in-the-treatment-of-chronic-pain-syndromes-from-nerve-injury-a-multicenter-observational-study
#3
Gianni Colini Baldeschi, Alessandro Dario, Giuliano De Carolis, Nicola Luxardo, Massimo Natale, Paola Nosella, Alfonso Papa, Massimiliano Raggi, Claudio Reverberi
INTRODUCTION: Assessing the feasibility, technical implications, and clinical benefits of peripheral nerve stimulation (PNS) performed by an implantable pulse generator (IPG) located close to the stimulation site. MATERIALS AND METHODS: Selected patients were affected by neuropathic pain associated with a documented peripheral nerve lesion, refractory to conventional surgical or pharmacological treatment. A PNS system specifically designed for peripheral placement (Neurimpulse, Padova, Italy) was implanted and followed for six months, recording the degree of patient's satisfaction (PGI-I questionnaire), the pain numerical rating scale (NRS) and the quality of life (SF36 questionnaire), as well as any change in drug regimen and work capability...
November 16, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27778413/altering-conventional-to-high-density-spinal-cord-stimulation-an-energy-dose-response-relationship-in-neuropathic-pain-therapy
#4
Frank Wille, Jennifer S Breel, Eric W P Bakker, Markus W Hollmann
OBJECTIVES: To examine whether converting from conventional Spinal Cord Stimulation (SCS) to High Density (HD) SCS reduces neuropathic pain over a period of 12 months in patients with failed SCS therapy. METHODS: Retrospective, open label, single center, consecutive case series of 30 neuropathic pain patients (Failed Back Surgery Syndrome [FBSS], Complex Regional Pain Syndrome [CRPS], and polyneuropathy [NP]). Patients with an initial adequate response to conventional SCS, but in whom pain increased over time, were included (Numeric Rating Scales [NRS] >6)...
October 24, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27767242/solubility-and-stability-of-baclofen-3-mg-ml-intrathecal-formulation-and-its-compatibility-with-implantable-programmable-intrathecal-infusion-systems
#5
Baohua Yue, Ron Brendel, Amelia Lukitsch, Thomas Prentice, Brian Doty
BACKGROUND: Commercial baclofen formulations used with infusion pumps are available at therapeutic concentrations of 0.5-2.0 mg/mL. However, patients who receive higher daily doses of baclofen may benefit from products with greater baclofen concentrations since their refill frequency would be reduced (up to a maximum of 180 days). We evaluated baclofen solubility, baclofen 3 mg/mL intrathecal (IT) formulation stability, and chemical and physical compatibility with Medtronic SynchroMed(®) II and Codman Medstream(®) programmable IT infusion pumps...
October 21, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27740708/trigemino-cervical-neuropathic-pain-relieved-by-serially-repeated-peripheral-nerve-field-stimulation-without-tolerance-case-report
#6
Brian A Simpson, Ravindra Nannapaneni
BACKGROUND: With its relative simplicity and safety, peripheral nerve field stimulation (PNFS; PENS) is contributing to the re-emergence of peripheral nerve stimulation as an effective therapy for neuropathic pain (NPP). CASE PRESENTATION: A 70-year-old woman had developed severe, medically refractory NPP unilaterally in the scalp and face 20 years earlier, following a maxillofacial surgical procedure. PNFS gave substantial relief of the pain and allodynia and was repeated successfully on a further 25 occasions over the subsequent five years...
October 14, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27730706/spinal-cord-stimulation-scs-the-implantable-systems-performance-registry-ispr
#7
David M Schultz, Aaron K Calodney, Alon Y Mogilner, Todd W Weaver, Michelle D Wells, E Katherine Stromberg, Mollie P Roediger, Peter E Konrad, John T Sasaki
OBJECTIVES: The Implantable Systems Performance Registry (ISPR) was created to monitor the product performance of Medtronic Spinal Cord Stimulation (SCS) and implanted intrathecal drug infusion systems available in the United States. MATERIALS AND METHODS: Data were collected on 2605 patients from 44 centers from various geographic regions across the United States implanting and following patients with SCS systems between June 25, 2004 and January 31, 2014. Actuarial life table methods are used to estimate device performance over time...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27730704/intrathecal-drug-delivery-systems-idds-the-implantable-systems-performance-registry-ispr
#8
Peter E Konrad, John M Huffman, Lisa M Stearns, Robert J Plunkett, Eric J Grigsby, E K Stromberg, Mollie P Roediger, Michelle D Wells, Todd W Weaver
OBJECTIVES: The ISPR was initially created to monitor the product performance of Medtronic implanted intrathecal drug infusion and spinal cord systems available in the United States. MATERIALS AND METHODS: Data were collected from 50 representative sites implanting and following patients with intrathecal drug delivery systems across the United States between August 7, 2003 and January 31, 2014. Device performance over time was estimated using life table survival methods...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27730703/subthalamic-nucleus-deep-brain-stimulation-alters-prefrontal-correlates-of-emotion-induction
#9
Sarah K B Bick, Bradley S Folley, Jutta S Mayer, Sohee Park, P David Charles, Corrie R Camalier, Srivatsan Pallavaram, Peter E Konrad, Joseph S Neimat
OBJECTIVES: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in advanced Parkinson's disease. STN DBS may also affect emotion, possibly by impacting a parallel limbic cortico-striatal circuit. The objective of this study was to investigate changes in prefrontal cortical activity related to DBS during an emotion induction task. MATERIALS AND METHODS: We used near infrared spectroscopy to monitor prefrontal cortex hemodynamic changes during an emotion induction task...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27730701/neurotransmitter-mechanisms-underlying-sacral-neuromodulation-of-bladder-overactivity-in-cats
#10
Jathin Bandari, Utsav Bansal, Zhaocun Zhang, Bing Shen, Jicheng Wang, Vladimir Lamm, Victor Chang, James R Roppolo, William C de Groat, Changfeng Tai
OBJECTIVE: To determine the role of opioid, β-adrenergic, and metabotropic glutamate 5 receptors in sacral neuromodulation of bladder overactivity. MATERIAL AND METHODS: In α-chloralose anesthetized cats, intravesical infusion of 0.5% acetic acid (AA) irritated the bladder and induced bladder overactivity. Electric stimulation (5 Hz, 0.2 ms, 0.16-0.7V) of S1 or S2 sacral dorsal roots inhibited the bladder overactivity. Naloxone, propranolol, or MTEP were given intravenously (i...
October 12, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27704654/the-influence-of-skin-redness-on-blinding-in-transcranial-direct-current-stimulation-studies-a-crossover-trial
#11
Fernando Ezquerro, Adriano H Moffa, Marom Bikson, Niranjan Khadka, Luana V M Aparicio, Bernardo de Sampaio-Junior, Felipe Fregni, Isabela M Bensenor, Paulo A Lotufo, Alexandre Costa Pereira, Andre R Brunoni
OBJECTIVE: To evaluate whether and to which extent skin redness (erythema) affects investigator blinding in transcranial direct current stimulation (tDCS) trials. MATERIAL AND METHODS: Twenty-six volunteers received sham and active tDCS, which was applied with saline-soaked sponges of different thicknesses. High-resolution skin images, taken before and 5, 15, and 30 min after stimulation, were randomized and presented to experienced raters who evaluated erythema intensity and judged on the likelihood of stimulation condition (sham vs...
October 5, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27696607/the-volume-outcome-effect-impact-on-trial-to-permanent-conversion-rates-in-spinal-cord-stimulation
#12
Kelly Ryan Murphy, Jing L Han, Syed Mohammed Qasim Hussaini, Siyun Yang, Beth Parente, Jichun Xie, Shivanand P Lad
OBJECTIVES: Conversion rates from trial leads to permanent spinal cord stimulation (SCS) systems have important implications for healthcare resource utilization (HCRU) and pain management. We hypothesized that there is a volume-outcome effect, with chronic pain patients who visit high volume SCS implanters will have higher trial-to-permanent conversion rates. MATERIALS AND METHODS: We designed a large, retrospective analysis using the Truven MarketScan database analyzing adult SCS patients with provider information available, with or without IPG implantation from the years 2007 to 2012 was designed...
October 3, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27696596/baclofen-solution-for-low-volume-therapeutic-delivery
#13
Jay M Meythaler, Jean D Peduzzi
OBJECTIVES: Baclofen is a zwitterion molecule where increased ions in the excipient increase the solubility. We developed baclofen in a stable solution similar to cerebrospinal fluid (CSF) without bicarbonate and proteins to improve the solubility of the baclofen and to reduce the potential toxicity to the central nervous system (CNS) and subarachnoid space. The objective is to develop a solution of baclofen wherein baclofen is solubilized in a multivalent physiological ion solution such as artificial cerebrospinal fluid (aCSF) at a concentration from 2 mg/cc to 10 mg/cc...
October 3, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27641444/cramp-training-induces-a-long-lasting-increase-of-the-cramp-threshold-frequency-in-healthy-subjects
#14
Michael Behringer, Volker Spieth, Johannes Caspar Konrad Montag, Steffen Willwacher, Molly Leigh McCourt, Joachim Mester
OBJECTIVE: A low cramp threshold frequency (CTF) is associated with an increased cramp susceptibility. Recent data indicate that the CTF can be substantially increased by a cramp training consisting of electrically induced muscle cramps (EIMCs). This study investigated if four cramp training sessions induce sustained effects on the CTF. METHODS: In ten healthy male subjects, EIMCs were induced in the gastrocnemius medialis of one leg (intervention leg, IL) twice a week, while the opposite leg served as control leg (CL)...
September 19, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27593414/twiddler-s-syndrome-and-neuromodulation-devices-a-troubled-marriage
#15
Maarten Moens, Francky Petit, Lisa Goudman, Ann De Smedt, Peter Mariën, Kelly Ickmans, Raf Brouns
OBJECTIVE: The occurrence of Twiddler's syndrome in subjects with neurostimulator devices is poorly understood and might be influenced by age, sex, BMI, use of medication or psychologic disorders. METHODS: Two hundred thiry-five patients who received a neuromodulator were included in this retrospective study in a period between 2008 and 2015. The subjects were divided into a group of Twiddler's syndrome patients (TS) and a group of non-Twiddler's patients (NTS)...
September 5, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27704692/response-high-frequency-10-khz-or-burst-spinal-cord-stimulation-in-failed-back-surgery-syndrome-patients-with-predominant-back-pain-preliminary-data-from-a-prospective-observational-study
#16
Leonardo Kapural, Jean-Pierre van Buyten, Paul Verrills
No abstract text is available yet for this article.
October 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27704691/calendar-of-events
#17
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27704690/response-a-systematic-evaluation-of-burst-spinal-cord-stimulation-for-chronic-back-and-limb-pain
#18
Dirk De Ridder, Sven Vanneste
No abstract text is available yet for this article.
October 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27593216/feasibility-of-three-dimensional-placement-of-human-therapeutic-stem-cells-using-the-intracerebral-microinjection-instrument
#19
Andreas Nørgaard Glud, Carsten Reidies Bjarkam, Nima Azimi, Karl Johe, Jens Christian Sorensen, Miles Cunningham
OBJECTIVES: The ability to safely place viable intracerebral grafts of human-derived therapeutic stem cells in three-dimensional (3D) space was assessed in a porcine model of human stereotactic surgery using the Intracerebral Microinjection Instrument (IMI) compared to a conventional straight cannula. MATERIALS AND METHODS: Two groups of healthy minipigs received injections of the human stem cell line, NSI-566, into the right hemisphere and cell suspension carrier media into the left hemisphere...
October 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27505059/primary-hydromorphone-related-intrathecal-catheter-tip-granulomas-is-there-a-role-for-dose-and-concentration
#20
I Elias Veizi, Salim M Hayek, Michael Hanes, Ryan Galica, Sivakanth Katta, Tony Yaksh
BACKGROUND: Intrathecal drug delivery therapy has been used effectively in treating patients with intractable chronic pain. The development of an intrathecal catheter tip granuloma (ICTG) related to delivery of intrathecal opiates is a relatively infrequent, but potentially devastating complication. While there are many morphine-related ICTG cases described, reports of hydromorphone-related ICTG are limited. In addition, studies suggest a strong correlation between the use of higher doses and concentrations of intrathecal opiates and ICTG formation...
October 2016: Neuromodulation: Journal of the International Neuromodulation Society
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