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Neuromodulation: Journal of the International Neuromodulation Society

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https://www.readbyqxmd.com/read/29152818/electrical-stimulation-of-dorsal-root-ganglion-in-the-context-of-pain-a-systematic-review-of-in-vitro-and-in-vivo-animal-model-studies
#1
REVIEW
Ivana Vuka, Katarina Vučić, Tihana Repić, Lejla Ferhatović Hamzić, Damir Sapunar, Livia Puljak
OBJECTIVE: Dorsal root ganglion (DRG) has recently emerged as an attractive target for neuromodulation therapy since primary sensory neurons and their soma in DRGs are important sites for pathophysiologic changes that lead to neuropathic pain. Our aim was to create evidence synthesis about the effects of electrical stimulation of DRG in the context of pain from in vitro and in vivo animal models, analyze methodology and quality of studies in the field. METHODS: For conducting systematic review we searched three data bases: MEDLINE, Embase and Web of Science...
November 20, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29143405/cost-effectiveness-modeling-of-repetitive-transcranial-magnetic-stimulation-compared-to-electroconvulsive-therapy-for-treatment-resistant-depression-in-singapore
#2
Ying Jiao Zhao, Phern Chern Tor, Ai Leng Khoo, Monica Teng, Boon Peng Lim, Yee Ming Mok
BACKGROUND: Compared to electroconvulsive therapy (ECT), the cost-effectiveness of repetitive transcranial magnetic stimulation (rTMS) in the management of treatment-resistant depression (TRD) remains unclear. OBJECTIVE/HYPOTHESIS: This study evaluated the cost-effectiveness of rTMS vs. ECT for TRD from Singapore societal perspective. METHODS: We constructed a Markov model to project the cost and benefit of rTMS compared with ECT over one year in patients with TRD...
November 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29131488/dorsal-root-ganglion-stimulation-used-for-the-treatment-of-chronic-neuropathic-pain-in-the-groin-a-single-center-study-with-long-term-prospective-results-in-34-cases
#3
Matthias Hubert Morgalla, Anil Bolat, Marcos Fortunato, Guilherme Lepski, Bankim Subhash Chander
OBJECTIVE: Chronic neuropathic pain in the groin is a severe condition and difficult to treat. Dorsal root ganglion stimulation (DRGS) covers discrete painful areas precisely with its stimulation power in comparison to spinal cord stimulation (SCS). It was our hypothesis that DRGS provides a long-term relief of chronic groin pain over a period of more than three years. MATERIALS AND METHODS: Patients (age >18 years) with chronic neuropathic groin pain were prospectively examined...
November 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29111577/applications-of-acupuncture-therapy-in-modulating-plasticity-of-central-nervous-system
#4
REVIEW
Ling-Yong Xiao, Xue-Rui Wang, Ye Yang, Jing-Wen Yang, Yan Cao, Si-Ming Ma, Tian-Ran Li, Cun-Zhi Liu
OBJECTIVE: Acupuncture is widely applied for treatment of various neurological disorders. This manuscript will review the preclinical evidence of acupuncture in mediating neural plasticity, the mechanisms involved. MATERIALS AND METHODS: We searched acupuncture, plasticity, and other potential related words at the following sites: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and VIP information data base. The following keywords were used: acupuncture, electroacupuncture, plasticity, neural plasticity, neuroplasticity, neurogenesis, neuroblast, stem cell, progenitor cell, BrdU, synapse, synapse structure, synaptogenesis, axon, axon regeneration, synaptic plasticity, LTP, LTD, neurotrophin, neurotrophic factor, BDNF, GDNF, VEGF, bFGF, EGF, NT-3, NT-4, NT-5, p75NTR, neurotransmitter, acetylcholine, norepinephrine, noradrenaline, dopamine, monamine...
November 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29105245/comparison-of-the-battery-life-of-nonrechargeable-generators-for-deep-brain-stimulation
#5
Ann-Kristin Helmers, Isabel Lübbing, Günther Deuschl, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Nonrechargeable deep brain stimulation (DBS) generators must be replaced when the battery capacity is exhausted. Battery life depends on many factors and differs between generator models. A new nonrechargeable generator model replaced the previous model in 2008. Our clinical impression is that the earlier model had a longer battery life than the new one. We conducted this study to substantiate this. METHODS: We determined the battery life of every DBS generator that had been implanted between 2005 and 2012 in our department for the treatment of Parkinson's disease, and compared the battery lives of the both devices...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29105244/spinal-cord-stimulation-for-treating-chronic-pain-reviewing-preclinical-and-clinical-data-on-paresthesia-free-high-frequency-therapy
#6
REVIEW
Krishnan Chakravarthy, Hira Richter, Paul J Christo, Kayode Williams, Yun Guan
BACKGROUND: Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not rely on paresthesia. STUDY DESIGN: A review of preclinical and clinical studies regarding the use of paresthesia-free HF-SCS for various chronic pain states. METHODS: We reviewed available literatures on HF-SCS, including Nevro's paresthesia-free ultra high-frequency 10 kHz therapy (HF10-SCS)...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29105225/is-the-self-reporting-of-failed-back-surgery-syndrome-patients-treated-with-spinal-cord-stimulation-in-line-with-objective-measurements
#7
Lisa Goudman, Iris Smet, Peter Mariën, Mats De Jaeger, Sander De Groote, Eva Huysmans, Koen Putman, Jean-Pierre Van Buyten, Ronald Buyl, Maarten Moens
OBJECTIVES: To understand the subjective pain experience of patients, healthcare providers rely heavily on self-reporting. However, to quantify this unique pain experience, objective parameters are not yet available in daily clinical practice. With regard to patients with failed back surgery syndrome (FBSS) treated with spinal cord stimulation (SCS), pain therapists may recover the individual functional information about the patient's posture from the implantable pulse generator (IPG) of the stimulator...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29094451/chemotherapy-induced-pica-in-rats-reduced-by-electroacupuncture
#8
Shiying Li, Yong Lei, Jiande D Z Chen
OBJECTIVES: Acupuncture or electroacupuncture (EA) has been applied for treating chemotherapy-induced emesis with limited success. The aims of this study were to investigate the anti-emetic effect of EA and to explore underlying anti-emetic mechanisms. MATERIALS AND METHODS: Rats were chronically implanted with a pair of stainless steel leads at acupoint pericardium 6 (PC6). Effects of EA with different parameters on cisplatin-induced nausea were assessed by pica (intake of kaolin, a surrogate of nausea in species without vomiting reflex)...
November 1, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29082637/peripheral-nerve-stimulation-for-painful-mononeuropathy-secondary-to-leprosy-a-12-month-follow-up-study
#9
Tiago da Silva Freitas, Erich Talamoni Fonoff, Oswaldo Ribeiro Marquez Neto, Iruena Moraes Kessler, Laura Mendes Barros, Ronan Wilk Guimaraes, Monalisa Ferreira Azevedo
OBJECTIVE: Leprosy affects approximately 10-15 million patients worldwide and remains a relevant public health issue. Chronic pain secondary to leprosy is a primary cause of morbidity, and its treatment remains a challenge. We evaluated the feasibility and safety of peripheral nerve stimulation (PNS) for painful mononeuropathy secondary to leprosy that is refractory to pharmacological therapy and surgical intervention (decompression). METHODS: Between 2011 and 2013 twenty-three patients with painful mononeuropathy secondary to leprosy were recruited to this prospective case series...
October 29, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29076214/thinking-small-progress-on-microscale-neurostimulation-technology
#10
REVIEW
Joseph J Pancrazio, Felix Deku, Atefeh Ghazavi, Allison M Stiller, Rashed Rihani, Christopher L Frewin, Victor D Varner, Timothy J Gardner, Stuart F Cogan
OBJECTIVES: Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational, and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation...
October 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29076212/high-resolution-multi-scale-computational-model-for-non-invasive-cervical-vagus-nerve-stimulation
#11
Antonios P Mourdoukoutas, Dennis Q Truong, Devin K Adair, Bruce J Simon, Marom Bikson
OBJECTIVES: To develop the first high-resolution, multi-scale model of cervical non-invasive vagus nerve stimulation (nVNS) and to predict vagus fiber type activation, given clinically relevant rheobase thresholds. METHODS: An MRI-derived Finite Element Method (FEM) model was developed to accurately simulate key macroscopic (e.g., skin, soft tissue, muscle) and mesoscopic (cervical enlargement, vertebral arch and foramen, cerebral spinal fluid [CSF], nerve sheath) tissue components to predict extracellular potential, electric field (E-Field), and activating function along the vagus nerve...
October 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29067749/combined-brain-and-peripheral-nerve-stimulation-in-chronic-stroke-patients-with-moderate-to-severe-motor-impairment
#12
Isabella S Menezes, Leonardo G Cohen, Eduardo A Mello, André G Machado, Paul Hunter Peckham, Sarah M Anjos, Inara L Siqueira, Juliana Conti, Ela B Plow, Adriana B Conforto
OBJECTIVES: To evaluate effects of somatosensory stimulation in the form of repetitive peripheral nerve sensory stimulation (RPSS) in combination with transcranial direct current stimulation (tDCS), tDCS alone, RPSS alone, or sham RPSS + tDCS as add-on interventions to training of wrist extension with functional electrical stimulation (FES), in chronic stroke patients with moderate to severe upper limb impairments in a crossover design. We hypothesized that the combination of RPSS and tDCS would enhance the effects of FES on active range of movement (ROM) of the paretic wrist to a greater extent than RPSS alone, tDCS alone or sham RPSS + tDCS...
October 25, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29065235/comparison-of-active-stimulating-electrodes-of-sacral-neuromodulation
#13
Xin Su, Matthew Cutinella, Jason E Agran, David A Dinsmoor
OBJECTIVE: The goal of this study was to compare the motor response to sacral neuromodulation (SNM) with different pairs of stimulating electrodes in anesthetized and awake sheep. MATERIALS AND METHODS: Similar to SNM clinical use in humans, the InterStim(®) quadripolar tined lead was implanted adjacent to the S3 nerve root in sheep and bipolar stimulation was configured with one electrode negative and one electrode positive on the four contacts (0 most distal to device, 1, 2, and 3 most proximal)...
October 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29064606/long-term-stability-of-short-circuits-in-deep-brain-stimulation
#14
Niels Allert, Egle Jusciute, Olga Weirich, Mohammadreza Daryaeitabar, Brit Meike Nolden, Hans Karbe
OBJECTIVES: To evaluate the long-term course of DBS electrodes with short-circuited contacts. MATERIALS AND METHODS: Electrodes with bipolar impedances below 150 Ω were identified from a cohort of 1044 patients with 2082 electrodes for variable movement disorders. The long-term course was analyzed from follow-up data. RESULTS: Short circuits were found in 62 electrodes (3.0%) from 60 patients (5.7%). They were restricted to two contacts in 57 electrodes (91...
October 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29064604/changes-of-metabolic-disorders-associated-peripheral-cytokine-adipokine-traffic-in-non-obese-chronic-back-patients-responsive-to-burst-spinal-cord-stimulation
#15
Sajjad Muhammad, Shafqat R Chaudhry, Thomas L Yearwood, Joachim K Krauss, Thomas M Kinfe
OBJECTIVES: In our previous study, anti-inflammatory IL-10 serum levels were significantly elevated after burst spinal cord stimulation (SCS) in back pain patients and correlated with pain intensity. This current study extended cytokine analysis including metabolic-associated adipokine/cytokine serum assessment in chronic back pain patients with co-existing metabolic disorders such as diabetes, hypertension, and cardiovascular diseases. METHODS: At baseline and after three months of burst SCS treatment, leptin (LP), adiponectin (AN), and ghrelin (GH) were recorded in non-/pre-obese chronic back pain patients with co-existing metabolic disorders and compared to age-/gender-matched healthy controls (HC)...
October 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29064599/spinal-cord-stimulation-in-patients-with-complex-regional-pain-syndrome-a-possible-target-for-immunomodulation
#16
Nadia Kriek, Marco W J Schreurs, J George Groeneweg, Wim A Dik, Gilbert C H Tjiang, Ismail Gültuna, Dirk L Stronks, Frank J P M Huygen
OBJECTIVE: Complex regional pain syndrome (CRPS) is characterized by continued pain disproportional to the inciting event, sensory abnormalities, vasomotor and sudomotor disturbances, and motor and trophic changes. Inflammatory involvement has been demonstrated in past CRPS studies resulting in pain, swelling, and warmth. Currently, it is unknown whether spinal cord stimulation (SCS) has immunomodulatory properties. The aim of this study was to determine whether SCS has immunomodulatory properties in CRPS patients...
October 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29058361/pain-remission-at-one-year-follow-up-with-spinal-cord-stimulation
#17
Hirah Khan, Julie G Pilitsis, Julia Prusik, Heather Smith, Sarah E McCallum
OBJECTIVES: Spinal Cord Stimulation (SCS) is an effective treatment for chronic pain. How often pain remission follows SCS has not been evaluated. This is a retrospective analysis of patients who underwent an implantation of spinal cord stimulators for various chronic pain conditions. The objective of the study was to elucidate characteristics and features of patients with pain relief greater than 80% after one year of treatment. METHODS: A total of 86 patients with thoracic SCS and 12-month follow-up data were identified...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29057550/in-vitro-magnetic-resonance-imaging-evaluation-of-fragmented-open-coil-percutaneous-peripheral-nerve-stimulation-leads
#18
Frank G Shellock, Armaan Zare, Brian M Ilfeld, John Chae, Robert B Strother
OBJECTIVE: Percutaneous peripheral nerve stimulation (PNS) is an FDA-cleared pain treatment. Occasionally, fragments of the lead (MicroLead, SPR Therapeutics, LLC, Cleveland, OH, USA) may be retained following lead removal. Since the lead is metallic, there are associated magnetic resonance imaging (MRI) risks. Therefore, the objective of this investigation was to evaluate MRI-related issues (i.e., magnetic field interactions, heating, and artifacts) for various lead fragments. METHODS: Testing was conducted using standardized techniques on lead fragments of different lengths (i...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29034542/time-frequency-analysis-of-increases-in-vaginal-blood-perfusion-elicited-by-long-duration-pudendal-neuromodulation-in-anesthetized-rats
#19
Indie C Rice, Lauren L Zimmerman, Shani E Ross, Mitchell B Berger, Tim M Bruns
OBJECTIVES: Female sexual dysfunction (FSD) affects a significant portion of the population. Although treatment options for FSD are limited, neuromodulation for bladder dysfunction has improved sexual function in some women. A few studies have investigated peripheral neuromodulation for eliciting changes in vaginal blood flow, as a proxy for modulating genital sexual arousal, however results are generally transient. Our central hypothesis is that repeated or extended-duration pudendal nerve stimulation can elicit maintained vaginal blood flow increases...
October 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29034586/avoiding-internal-capsule-stimulation-with-a-new-eight-channel-steering-deep-brain-stimulation-lead
#20
Kees J van Dijk, Rens Verhagen, Lo J Bour, Ciska Heida, Peter H Veltink
OBJECTIVE: Novel deep brain stimulation (DBS) lead designs are currently entering the market, which are hypothesized to provide a way to steer the stimulation field away from neural populations responsible for side effects and towards populations responsible for beneficial effects. The objective of this study is to assess the performances of a new eight channel steering-DBS lead and compare this with a conventional cylindrical contact (CC) lead. APPROACH: The two leads were evaluated in a finite element electric field model combined with multicompartment neuron and axon models, representing the internal capsule (IC) fibers and subthalamic nucleus (STN) cells...
October 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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