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Annals of Transplantation: Quarterly of the Polish Transplantation Society

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https://www.readbyqxmd.com/read/30409961/colonoscopy-as-part-of-pre-transplant-work-up-in-successful-kidney-transplant-candidates-single-center-experience-and-review-of-literature
#1
Jarek Kobiela, Małgorzata Dobrzycka, Roman Danielewicz, Justyna Jończyk, Andrzej J Łachiński, Zbigniew Śledziński, Alicja Dębska-Ślizień
BACKGROUND Screening colonoscopy is not obligatory in kidney pre-transplant work-up guidelines. According to recommendations, only transplant recipients over age 50 years should be screened. The aim of this study was to characterize endoscopic findings revealed as part of pre-transplant work-up. MATERIAL AND METHODS We retrospectively reviewed pre-transplant work-up charts of 434 adult patients who received a cadaveric donor kidney transplantation (KT) from 2012 to 2015. Endoscopic findings analysis with age subgroup (<50 and ³50) analysis were performed...
November 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30397188/association-of-kidney-donor-risk-index-with-the-outcome-after-kidney-transplantation-in-the-eurotransplant-senior-program
#2
Beate Schamberger, Dario Lohmann, Daniel Sollinger, Raimund Stein, Jens Lutz
BACKGROUND We evaluated the Kidney Donor Risk Index (KDRI) scoring system for kidney transplantation in the Eurotransplant Senior Program (ESP) that allocates kidneys from older donors to older recipients (≥65 years). MATERIAL AND METHODS We retrospectively analyzed data of 37 kidney transplant recipients and 36 kidney donors who participated in kidney transplantation program according to the ESP at our center from January 2004 until December 2013. RESULTS Mean recipient and donor age was 67.9±2.6 and 70...
November 6, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30385737/risk-factors-for-intensive-care-unit-readmission-after-liver-transplantation-a-retrospective-cohort-study
#3
Young Gon Son, Hannah Lee, Seung Young Oh, Chul-Woo Jung, Ho Geol Ryu
BACKGROUND Most liver transplant patients require Intensive Care Unit (ICU) care in the immediate postoperative period and some patients require readmission to the ICU before discharge from the hospital. A retrospective cohort study was conducted to identify risk factors for ICU readmission after liver transplantation. MATERIAL AND METHODS Adult patients who underwent living donor or deceased donor liver transplantation at Seoul National University Hospital between 2004 and 2015 were included. A retrospective review of baseline and perioperative factors that may be associated with ICU readmission was performed...
November 2, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30374013/comprehensive-evaluation-of-a-donated-after-circulatory-death-dcd-donor-liver-model-in-minipigs
#4
Guang Wang, Ying Cheng, Yongfeng Liu
BACKGROUND Graft livers from donors after death from circulatory disease (DCD) often suffer injury from severe ischemia or hypoxia before resection. Thus, earlier evaluation of these livers is critical for the survival of recipients. MATERIAL AND METHODS In our study, 18 minipigs, as DCD donor liver models, were evenly divided into a warm ischemia time (WIT) group and a hypoxia plus ischemia group. Another 18 minipigs served as recipients and were implanted with the donor livers of the DCD models. miR-122 levels and hepatic function were examined before and after liver transplantation...
October 30, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30361470/association-between-renal-dysfunction-and-major-adverse-cardiac-events-after-liver-transplantation-evidence-from-an-international-randomized-trial-of-everolimus-based-immunosuppression
#5
Faouzi Saliba, Lutz Fischer, Paolo de Simone, Peter Bernhardt, Giovanni Bader, John Fung
BACKGROUND Prospective evidence is lacking regarding the association between renal dysfunction and cardiovascular events after liver transplantation. MATERIAL AND METHODS Data were analyzed post hoc regarding renal function and major adverse cardiac events in a two-year prospective trial of de novo liver transplant recipients randomized at 30 days post-transplant to (i) everolimus [EVR]/reduced tacrolimus [EVR/rTAC] (ii) EVR with tacrolimus discontinued [TAC Elimination] or (iii) standard tacrolimus [TAC Control]...
October 26, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30348935/everolimus-use-for-intolerance-or-failure-of-baseline-immunosuppression-in-adult-heart-and-lung-transplantation
#6
Shelby E Kelsh, Reda Girgis, Michael Dickinson, Jennifer K McDermott
BACKGROUND Everolimus can be utilized after heart or lung transplantation to reduce calcineurin inhibitor associated nephrotoxicity, due to cell cycle inhibitor adverse effects, and as adjunct therapy for rejection, cardiac allograft vasculopathy, and bronchiolitis obliterans syndrome. MATERIAL AND METHODS A single-center, retrospective cohort study was conducted including 51 adult heart transplant patients (n=32) and lung transplant patients (n=19) started on everolimus due to immunosuppressive therapy intolerance or failure, between 2010 and 2017...
October 23, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30337516/clinical-outcomes-of-tuberculosis-in-recipients-after-living-donor-liver-transplantation
#7
Noruel Gerard A Salvador, Sin-Yong Wee, Chih-Che Lin, Chao-Chien Wu, Hung-I Lu, Ting-Lung Lin, Wei-Feng Lee, Yi-Chia Chan, Li-Man Lin, Chao-Long Chen
BACKGROUND This study aimed to determine clinical outcomes using various drugs during tuberculosis (TB) treatment among living donor liver transplant (LDLT) recipients with TB and to assess the impact of performing LDLT in patients with active TB at the time of LDLT. MATERIAL AND METHODS Out of 1313 LDLT performed from June 1994 to May 2016, 26 (2%) adult patients diagnosed with active TB were included in this study. Active TB was diagnosed using either TB culture, PCR, and/or tissue biopsy. RESULTS The median age was 56 years and the male/female ratio was 1...
October 19, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30323164/intraoperative-surgical-portosystemic-shunt-in-liver-transplantation-systematic-review-and-meta-analysis
#8
Lucas Souto Nacif, Leonardo Yuri Zanini, Vinicius Farina Sartori, Vera Kim, Vinicius Rocha-Santos, Wellington Andraus, Luiz Carneiro D'Albuquerque
BACKGROUND Expanded clinical and surgical techniques in liver transplantation can markedly improve patient and graft survival. The main purpose of this study was to evaluate the efficacy of intraoperative portocaval shunts in liver transplantation. MATERIAL AND METHODS Searches were conducted in Cochrane, MEDLINE, and EMBASE databases, and updated in January 2018. The following specific outcomes of interest were defined and evaluated separated using 2 different reviews and meta-analyses for 1) hemi-portocaval shunt (HPCS) and 2) temporary portocaval shunt (TPCS)...
October 16, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30310047/safety-and-efficacy-of-once-daily-prolonged-release-tacrolimus-in-living-donor-liver-transplantation-an-open-label-prospective-single-arm-phase-4-study
#9
Eung Chang Lee, Seong Hoon Kim, Sang-Jae Park
BACKGROUND After liver transplantation (LT), nonadherence to immunosuppressants due to the complex regimen can lead to graft rejection and loss. This study assessed the efficacy and safety of conversion from twice-daily tacrolimus (Bid-Tac) to once-daily prolonged-release tacrolimus (OD-Tac) in living donor LT (LDLT) recipients. MATERIAL AND METHODS Among patients who underwent LDLT between November 2015 and October 2016, those who agreed to participate in this study were screened, and those with good general condition and stable liver functions were enrolled...
October 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30297686/risk-factors-of-acute-rejection-in-patients-with-bk-nephropathy-after-reduction-of-immunosuppression
#10
Chung Hee Baek, Hyosang Kim, Hoon Yu, Won Seok Yang, Duck Jong Han, Su-Kil Park
BACKGROUND BK nephropathy (BKN) affects graft function and increases the risk of graft failure. The reduction of immunosuppression is the main treatment for BKN. However, acute rejection may develop following immunosuppression reduction, and data regarding the risk factors of acute rejection during the post-reduction period are insufficient. MATERIAL AND METHODS Of 758 patients who received a kidney transplantation (KT) between 2008 and 2011, 79 who underwent immunosuppression reduction as BKN treatment were enrolled...
October 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30287804/utilization-of-standard-criteria-donor-and-expanded-criteria-donor-kidneys-after-kidney-allocation-system-implementation
#11
Catherine E Kling, James D Perkins, Christopher K Johnson, Christopher D Blosser, Nicolae Leca, Lena Sibulesky
BACKGROUND Implementation of the Kidney Allocation System (KAS) changed how kidneys are allocated and the information on which organ utilization decisions are based. We aimed to evaluate how KAS implementation changed kidney utilization and recipient outcomes. MATERIAL AND METHODS Using the United Network for Organ Sharing database, we identified recipients of kidney transplants from donors with kidney donor profile index (KDPI) of 61-90% in the 5-years pre- and 18-months post-KAS implementation and examined patient and graft survival and donor kidney discard rates based on standard criteria donor (SCD) or expanded criteria donor (ECD) status...
October 5, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30275438/fence-angioplasty-prevents-narrowing-of-venous-anastomosis-in-solitary-pancreas-transplant
#12
Je Ho Ryu, Tae Beom Lee, Kwang Ho Yang, Taeun Kim, Young Soo Chung, Byunghyun Choi
BACKGROUND Graft thrombosis is the leading cause of early graft failure in pancreas transplants. Direct anastomosis grafting of the portal vein to the iliac vein or vena cava generally appears narrowed on postoperative computed tomography (CT) scans. However, modification of surgical techniques may prevent venous narrowing, which also prevents thrombosis-related graft failure. MATERIAL AND METHODS We performed 31 solitary pancreas transplants since 2015. Retrospective analysis of these patients was performed...
October 2, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30262798/pictorial-representation-of-illness-and-self-measure-prism-a-novel-visual-instrument-to-quantify-suffering-in-liver-cirrhosis-patients-and-liver-transplant-recipients
#13
Iyad Kabar, Anna Hüsing-Kabar, Miriam Maschmeier, Carolin Völler, Marina Dümke, Hartmut H Schmidt, Hauke Heinzow
BACKGROUND The level of suffering of chronically ill patients does not necessarily correlate with illness severity. In this study, we evaluated the burden of suffering and its impact on health-related quality of life in liver transplant recipients and liver cirrhosis patients. MATERIAL AND METHODS The Pictorial Representation of Illness and Self Measure (PRISM) was used to explore levels of suffering in outpatients of Münster University Hospital, Germany. Self-illness separation scores were analyzed as a measure of disease-specific burden of suffering...
September 28, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30250015/liver-transplantation-for-progressive-familial-intrahepatic-cholestasis
#14
Ying Liu, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng
BACKGROUND Progressive familial intrahepatic cholestasis (PFIC) is an autosomal recessive inherited disease that disrupts the genes for bile formation. Liver transplantation (LT) is the only effective treatment for PFIC patients with end-stage liver disease. We describe our experience in terms of clinical characteristics, complications, and outcome of LT for PFIC. CASE REPORT The data of 5 pediatric PFIC patients recipients (3 PFIC1, 1 PFIC2, and 1 PFIC3) who received LT at our Liver Transplant Center from June 2013 to February 2017 were retrospectively analyzed...
September 25, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30237389/clinical-features-and-surveillance-of-very-late-hepatocellular-carcinoma-recurrence-after-liver-transplantation
#15
Abdulwahab A Alshahrani, Su-Min Ha, Shin Hwang, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Hwi-Dong Cho, Jae Hyun Kwon, Sang-Hyun Kang, Sung-Gyu Lee
BACKGROUND This study aimed to assess patterns of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and to establish long-term surveillance protocols for late HCC recurrence. MATERIAL AND METHODS The 232 LT recipients experiencing subsequent HCC recurrence were categorized as Group 1, early recurrence (within 1 year of LT; n=117); Group 2, late recurrence (occurring in years 2-5; n=93); and Group 3, very late recurrence (after year 5; n=22). RESULTS Recurrence was detected by only elevated tumor marker levels in 11...
September 21, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30224627/strategies-to-improve-patient-engagement-in-young-kidney-transplant-recipients-a-review
#16
Vanessa L Richards, Christopher K Johnson, Christopher D Blosser, Lena Sibulesky
Young adult and adolescent kidney transplant recipients have shorter graft survival than older and younger recipients. Although multifactorial, the tendency toward premature graft loss in young kidney transplant recipients has often been attributed to medication nonadherence and the transition from pediatric to adult care. Multiple interventions for medication nonadherence in kidney transplant recipients have been studied. Potential preventative interventions include pre-transplant screening, transition and young adult clinics, technologies such as reminders or mobile applications, and simplification of the post-transplant medication regimen...
September 18, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30213924/factors-in-organ-donation-coordinators-a-cross-sectional-study-in-china
#17
Ping Mao, Pingping Cai, Aijing Luo, Panhao Huang, Wenzhao Xie
BACKGROUND Organ donation coordinators play an important role in the organ transplantation process. Job burnout can seriously affect their turnover rates and the organ donation rate. The present study investigated the level of job burnout and its related factors among organ donation coordinators in China. MATERIAL AND METHODS From March to May 2017, we administered questionnaire surveys to 320 organ donation coordinators from 32 cities. The questionnaire included the following: the Chinese version of MBI-GS was used to evaluate the burnout levels of organ donation coordinators, the Chinese version of GSES was used to assess related personal factors, and the Job Demands Scale and the SSRS were used to evaluate related environmental factors...
September 14, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30201946/albumin-bilirubin-score-for-predicting-post-transplant-complications-following-adult-to-adult-living-donor-liver-transplantation
#18
Wei Zhang, Chang Liu, Yifei Tan, Lingcan Tan, Li Jiang, Jian Yang, Jiayin Yang, Lunan Yan, Tianfu Wen
BACKGROUND Albumin-Bilirubin (ALBI) grade has been evaluated as an objective method to assess liver function and predict postoperative complications, particularly after hepatectomy in patients with hepatocellular carcinoma (HCC). However, ALBI grade was rarely used in evaluation in living donor liver transplantation (LDLT). MATERIAL AND METHODS Between March 2005 and November 2015, 272 consecutive patients undergoing right-lobe LDLT were enrolled in this study. According to the ALBI score used to evaluate recipients preoperatively, those patients were divided into 3 grades (I, II, and III)...
September 11, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30190449/effect-of-immunosuppressive-therapy-on-the-occurrence-of-atypical-hemolytic-uremic-syndrome-in-renal-transplant-recipients
#19
Rupesh Raina, Abigail Chauvin, Kelli Fox, Natasha Kesav, Mustafa Ascha, Tushar J Vachharajani, Vinod Krishnappa
BACKGROUND Atypical hemolytic uremic syndrome (aHUS), a rare thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Caused by genetic mutations in the alternative complement cascade, aHUS often will culminate in end-stage renal disease and occasionally death. Renal transplantation in aHUS patients has been contraindicated in the past due to the recurrence risk, with certain immunosuppressive regimens being commonly attributed. In this study, we analyzed the association between aHUS and immunosuppressive agents so as to offer evidence for the use of certain immunosuppressive regimens in renal transplant recipients...
September 7, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30177675/pretransplant-qt-interval-the-relationship-with-severity-and-etiology-of-liver-disease-and-prognostic-value-after-liver-transplantation
#20
Renata Główczyńska, Michalina Galas, Urszula Ołdakowska-Jedynak, Michał Peller, Mariusz Tomaniak, Joanna Raszeja-Wyszomirska, Piotr Milkiewicz, Marek Krawczyk, Krzysztof Zieniewicz, Grzegorz Opolski
BACKGROUND Prolonged QT interval is an integral part of the definition of cirrhotic cardiomyopathy. The aim of this study was to analyze the relationship between QT corrected (QTc) and the etiology and the severity of liver disease in relation to the complications of cirrhosis in candidates for orthotropic liver transplantation (OLTx). MATERIAL AND METHODS From 360 consecutive patients with end-stage liver disease (ESLD) consulted by a designated cardiologist, 160 patients underwent OLTx. The QTc was calculated according to 3 formulas in 151 ECG tracings with good quality...
September 4, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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