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Annals of Transplantation: Quarterly of the Polish Transplantation Society

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https://www.readbyqxmd.com/read/27920423/de-novo-renal-neoplasia-after-kidney-transplantation-according-to-new-2016-who-classification-of-renal-tumors
#1
Albino Eccher, Luigino Boschiero, Brett Delahunt, Luca Cima, Francesca Fior, Francesco Nacchia, Momo Rostand, Amedeo Carraro, Umberto Tedeschi, Gianluigi Zaza, Marilena Casartelli Liviero, Laura Zampicinini, Marco Chilosi, Giuseppe Feltrin, Claudio Rago, Antonietta D'Errico, Claudio Ghimenton, Guido Martignoni, Matteo Brunelli
BACKGROUND De novo renal neoplasia developing after kidney transplantation at Verona Kidney Transplant Center were reviewed according to new 2016 WHO Renal Tumor Classification. MATERIAL AND METHODS Primary renal tumors developed in native or transplanted kidneys de novo following renal transplantation were retrieved and histologically reviewed by three expert uropathologists. Immunoexpression of the diagnostic antigens CD13, CD10, CK7, CK34bE12, AMACR, CAIX, AE1/AE3, CK14, GATA-3, HMB-45, cathepsin-k, S100A1, and parvalbumin was assessed...
December 6, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27909288/reconstruction-of-isolated-inferior-right-hepatic-vein-s-in-right-lobe-living-donor-liver-transplantation-using-polytetrafluoroethylene-grafts-a-new-feasible-concept-technique-of-bridging-conduit-venoplasty-and-outcomes
#2
Ashok Thorat, Shih-Chao Hsu, Horng-Ren Yang, Ping-Chun Li, Ming-Li Li, Chun-Chieh Yeh, Te-Hung Chen, Kin-Shing Poon, Long-Bin Jeng
BACKGROUND Right lobe living donor liver transplantation (LDLT) remains the most common form of liver transplantation in Asia. However, reconstruction of the venous outflow in a right liver allograft may pose technical difficulties if hepatic venous variations are present. Recently, much emphasis has been given to the reconstruction of large and multiple inferior right hepatic veins (IRHVs). The method of reconstructive technique, type of vascular grafts, and the outcome after the procedure have been a point of debate...
December 2, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27885250/cxc-chemokine-receptor-4-cxcr4-antagonist-a-novel-pathway-to-prevent-chronic-allograft-nephropathy
#3
Yue Xu, Qiang Zhang, Wenrui Xue, Song Zeng, Zijian Zhang, Xiaodong Zhang, Xiaopeng Hu
BACKGROUND Chronic allograft nephropathy (CAN) remains a major problem for long-term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4) is significantly upregulated following renal injury and fibrotic response. We investigated the effect of AMD3100, a CXCR4 antagonist, on the development of CAN in rat models. MATERIAL AND METHODS CAN rat models (n=20) were established using male Fisher 344 to Lewis rats. Rats in the experimental group (n=10) were treated with AMD3100 (1 mg/kg/day subcutaneously, 0-12 weeks), rats in the control group (n=10) were treated with saline...
November 25, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27872471/recent-progress-in-xenotransplantation-with-emphasis-on-virological-safety
#4
Joachim Denner
Xenotransplantation is a new technology that may help to overcome the shortage of human tissues and organs available for the treatment of tissue and organ failure. Remarkable progress has recently been made in this field. First, understanding of the mechanisms of immunological rejection, mainly of the hyperacute rejection, allowed generating numerous genetically modified pigs to overcome rejection. Second, based on these genetically modified animals and new immunosuppression regimens, long-term survival of non-human primate recipients of heart, kidney, and islet cell cells has been reported...
November 22, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27857033/does-matching-donor-recipient-age-affect-long-term-survival-in-liver-transplantation
#5
Cristina Dopazo, Itxarone Bilbao, Lluis Castells, Mireia Caralt, Elena Fernández de Sevilla, José Luis Lázaro, Ramón Charco
BACKGROUND The characteristics of liver donors have changed over the last decade owing to the shortage of organs and high mortality on the waiting list, leading to wider use of extended-criteria donors, including older donors. The aim of this study was to evaluate the effect of matching donor-recipient age on morbidity at 1 year post-transplant and on long-term patient and graft survival. MATERIAL AND METHODS Retrospective study from a prospectively-obtained database including adult patients who had received a primary liver transplant (LT) from whole graft of brain-dead donors...
November 18, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27843133/evaluation-of-factors-limiting-corneal-donation
#6
Daniel Röck, Johanna Wude, Efdal Yoeruek, Karl Ulrich Bartz-Schmidt, Tobias Röck
BACKGROUND This study aimed to investigate factors limiting corneal donation at the University Hospital Tübingen. MATERIAL AND METHODS We retrospectively studied all hospital deaths from January 2012 to December 2015, considering each deceased patient as a potential corneal donor. During this period an ophthalmic resident managed corneal donor procurement on a full-time basis. Various factors limiting corneal donation were examined. RESULTS Among the 3412 deaths, 2937 (86.1%) displayed nonfulfillment of corneal donation...
November 15, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27840405/effects-of-reactive-oxygen-species-on-differentiation-of-bone-marrow-mesenchymal-stem-cells
#7
Yao Shi, Yiwen Hu, Chen Lv, Guanjun Tu
BACKGROUND The low differentiation rates for transplanted stem cells are challenging problems in spinal cord injury (SCI) treatment. Studies have demonstrated that the inhibition of the Notch1 pathway in bone marrow mesenchymal stem cells (BMSCs) contributed to the differentiation of these cells. Research findings that certain antioxidants induce BMSCs to differentiate into neuronal cells suggest that BMSC differentiation is related to the level of reactive oxygen species (ROS) in cells. This study aimed to define the effect of ROS on the differentiation of BMSCs...
November 14, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27821834/impact-of-postoperative-bleeding-on-short-term-outcome-in-patients-after-orthotopic-heart-transplantation-a-retrospective-cohort-study
#8
Anna Kędziora, Karol Wierzbicki, Piotr Mazur, Bryan HyoChan Song, Jacek Piątek, Irena Milaniak, Piotr Węgrzyn, Bogusław Kapelak, Rafał Drwiła, Dorota Sobczyk, Izabela Górkiewicz-Kot, Krzysztof Bartuś, Bogdan Niekowal, Jerzy Sadowski
BACKGROUND Orthotopic heart transplantation (HTX) remains the ultimate treatment option in patients with end-stage heart failure, endorsed by the European Society of Cardiology guidelines. The aim of the study is a complex evaluation of the postoperative bleeding after HTX and its influence on short-term outcome. MATERIAL AND METHODS A retrospective cohort study consisted of 53 patients (4 females and 49 males, median age 52.5 years, IQR 17 years) who underwent HTX in the Department of Cardiovascular Surgery and Transplantology of John Paul II Hospital in Krakow between 2007 and 2014...
November 8, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27811833/generalized-posttransplant-kaposi-sarcoma-without-mucocutaneous-manifestations-in-the-first-liver-transplantation-in-an-hiv-positive-patient-in-poland-a-case-report-and-review-of-literature
#9
Bogna Ziarkiewicz-Wróblewska, Magdalena M Suchacz, Krzysztof Zieniewicz, Michał Ciszek, Urszula Ołdakowska-Jedynak, Krzysztof Dudek, Tadeusz Wróblewski, Michał Mazurkiewicz, Barbara Górnicka, Leszek Pączek, Marek Krawczyk, Alicja Wiercińska-Drapało
BACKGROUND Kaposi sarcoma (KS) is the most frequent skin cancer in solid organ recipients, and also a typical malignancy in HIV-infected persons. CASE REPORT We describe here a rare case of primary nodal KS without mucocutaneous manifestations, diagnosed in a 20-year-old HIV/HBV co-infected patient 12 months after liver transplantation (LT), the first one performed in a HIV-positive patient in Poland. The course of the disease was very aggressive; the patient died four weeks after general lymphadenopathy appearance...
November 4, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27799654/impact-of-inter-laboratory-variability-on-model-of-end-stage-liver-disease-meld-score-calculation
#10
Mohammed Al-Saeedi, Taha Yassein, Daniel Schultze, Arash Nickkholgh, Helge Bruns, Markus Zorn, Ulf Hinz, Tom M Ganten, Peter Schemmer
BACKGROUND The model for end-stage liver disease (MELD) is a laboratory-based scoring system for assessing the severity of liver disease. Since 16 December 2006, MELD-based organ allocation for liver transplantation (LT) has been established in Germany to prioritize the sickest patients. The present study was designed to evaluate the effect of using different laboratories on the calculated MELD score, despite the use of mandatory round-robin testing for comparable of inter-laboratory results. MATERIAL AND METHODS Blood samples were taken from 10 patients with liver disease...
November 1, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27789901/assigning-treatment-to-hcc-patients-for-transplantation-utility-of-a-new-decision-making-tool
#11
Najmul Hassan Shah, Faisal Saud Dar, Abu Bakar Hafeez Bhatti, Atif Rana, Mohammad Salih
BACKGROUND The Barcelona clinic liver cancer (BCLC) staging system is considered the standard of care for hepatocellular carcinoma (HCC) management. It has various limitations, including lack of second-line treatment options and combination therapy. We prospectively collected data on our HCC patients based on a new decision-making tool (NDT). The objective of this study was to determine the applicability of this tool and compare it with BCLC for treatment allocation, in particular with respect to liver transplantation...
October 28, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27777395/diagnostic-role-of-blood-tumor-markers-in-predicting-hepatocellular-carcinoma-in-liver-cirrhosis-patients-undergoing-liver-transplantation
#12
Younghwan Kim, Yo-Han Park, Shin Hwang, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
BACKGROUND The aim of this study was to investigate the diagnostic role of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) in predicting hepatocellular carcinoma (HCC) in patients with advanced liver cirrhosis (LC) awaiting liver transplantation (LT). MATERIAL AND METHODS During a study period of 10 years, 2074 adult LT recipients were identified. They were divided into 2 groups: HCC (n=970; 46.8%) and non-HCC (n=1104; 53.2%). They were stratified into 5 categories according to model for end-stage liver disease (MELD) scores: <10 (n=464), ≥10 and <15 (n=632), ≥15 and <20 (n=355), ≥20 and <30 (n=340), and ≥30 (n=283)...
October 25, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27765937/neither-isolated-hepatic-arterial-clamping-nor-hepatic-arterial-ligation-induce-ischemic-type-biliary-lesions-in-rats
#13
Ulrich Keppler, Mohammed R Moussavian, Pascal Jeanmonod, Moritz J Strowitzki, Mathias Wagner, Claudia Scheuer, Michael D Menger, Maximilian von Heesen
BACKGROUND Ischemic type biliary lesions (ITBL) is a troublesome complication after liver transplantation. Little is known about its pathogenesis and there is particularly little data about morphological alterations. Prolonged warm and cold ischemia time and reduced hepatic arterial perfusion are risk factors leading to ITBL. There are only a few animal models described in literature. Therefore, we examined the effects of 3 h of hepatic artery ischemia-reperfusion (3 h I/R) and hepatic arterial ligation (HAL), both combined with ligation of the peribiliary plexus (PBP)...
October 21, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27752034/follow-up-of-pediatric-liver-transplant-patients-after-reaching-adulthood
#14
Justyna Rajchert, Monika Rosa, Joanna Pawłowska, Milosz Parczewski, Marta Wawrzynowicz-Syczewska
BACKGROUND Despite excellent transplantation results, there is a vulnerable period of time in the post-transplant management of pediatric liver recipients, which is the time when a child becomes an adolescent. This period of psychological distress influences compliance and may result in premature transplant failure and graft loss. We performed a retrospective review of pediatric liver transplant recipients, transferred to our service for adults, in order to identify key issues associated with transition into the adult care...
October 18, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27739420/new-perspectives-on-treatment-of-hepatitis-b-before-and-after-liver-transplantation
#15
Alberto Zanetto, Alberto Ferrarese, Ilaria Bortoluzzi, Patrizia Burra, Francesco Paolo Russo
The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments have improved the outcome of patients with both compensated and decompensated liver disease in some specific clinical settings as acute-on-chronic liver failure mortality is still high. Moreover, the incidence of HBV-related hepatocellular carcinoma (HCC) seems to be increasing and represents a major challenge for the transplant team...
October 14, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27725626/long-term-effect-of-body-mass-index-changes-on-graft-damage-markers-in-patients-after-kidney-transplantation
#16
Ilona Kurnatowska, Aneta Małyska, Kamila Wysocka, Katarzyna Mazur, Joanna Krawczyk, Michał Nowicki
BACKGROUND Both adiposity and underweight are negatively associated with graft and patient survival after kidney transplantation (KTx). The aim of this longitudinal study was to evaluate the changes in body mass index (BMI) after KTx and their relations with graft damage markers. MATERIAL AND METHODS The anthropometric measurements of body mass and height were performed in 92 consecutive deceased donor kidney transplant recipients (37 F; 55 M) from a single transplant center. Patient medical history, estimated glomerular filtration rate (eGFR), serum lipids, and ACR (urine albumin-to-creatinine ratio) was obtained from medical charts...
October 11, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27713391/resolution-of-hepatic-venous-congestion-following-gradual-occlusion-of-middle-hepatic-vein-interposition-graft-in-living-donor-liver-transplantation
#17
Varvara A Kirchner, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Dong-Hwan Jung, Tae-Yong Ha, Gil-Chun Park, Sung-Gyu Lee
BACKGROUND The middle hepatic vein (MHV) interposition vessel graft (IVG) is often occluded within a few months after living-donor liver transplantation (LDLT). We aimed to assess the mechanisms of resolving the hepatic venous congestion (HVC) that develops after gradual occlusion of the MHV-IVG. MATERIAL AND METHODS This study comprised two parts. Part I involved an assessment of the process of HVC resolution in the remnant right liver after donation of an extended left liver graft (n=100). Part II involved an evaluation of the timing and patterns of gradual MHV-IVG occlusion and HVC resolution in LDLT recipients (n=100)...
October 7, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27698337/the-potential-role-of-il-33-in-renal-transplant-recipients-with-chronic-allograft-dysfunction
#18
Jiexiu Zhang, Zijie Wang, Zhen Xu, Zhijian Han, Jun Tao, Pei Lu, Zhengkai Huang, Wanli Zhou, Chunchun Zhao, Ruoyun Tan, Min Gu
BACKGROUND Chronic allograft dysfunction (CAD) is the major factor endangering the long-term allograft survival in kidney transplantation. The mechanisms of CAD remain unclear. MATERIAL AND METHODS A total of 64 renal transplant recipients were enrolled in our study and divided into a stable group and CAD group according to their allograft function. A group of 32 normal controls (healthy volunteers) were also included. An ELISA was used to detect serum interleukin-33 (IL-33), IL-2, IL-4, IL-10, IL-17, and interferon-gamma (IFN-γ)...
October 4, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27646850/effect-of-fibrin-glue-on-the-incidence-of-surgical-complications-after-living-related-donor-kidney-transplantation-results-of-a-randomized-clinical-trial
#19
Clotilde Fuentes-Orozco, Salvador González-Mercado, Joel Mario Sandoval-Sandoval, Carlos Valdespino-Mejía, Eduardo González-González, Juan Narciso Ramírez-Robles, Benjamín Gómez-Navarro, Blanca Estela Dávalos-Delgadillo, Leticia Marquez-Leaño, Anais Ramírez-Arce, Elizabeth Andalón-Dueñas, Arturo Espinosa-Partida, Michel Dassaejv Macías-Amezcua, Alejandro González-Ojeda
BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinical trial involving 78 recipients randomly assigned to receive fibrin glue and 79 in the control group without the application of fibrin glue. Patients were followed for six months after surgery...
September 20, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27618946/evaluation-of-pre-transplant-panel-reactive-antibody-levels-and-sensitization-a-single-center-study
#20
Özgür Can, Ali Murat Gökçe, Mustafa Canbakan, Pınar Ata, Gülizar Manga Şahin, Mesut İzzet Titiz, Süheyla Apaydın
BACKGROUND Sensitization is one of the most important barriers against transplantation. Our aim was to evaluate the sensitization status of our patients awaiting cadaveric transplantation and to identify factors causing sensitization. MATERIAL AND METHODS A total of 140 patients on the cadaveric waiting list during January 2014 were included in this retrospective cross-sectional study. The parametric t-test and the non-parametric chi-square test were used to detect differences between PRA-positive and -negative patients...
September 13, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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