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Annals of Transplantation: Quarterly of the Polish Transplantation Society

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https://www.readbyqxmd.com/read/30213924/factors-in-organ-donation-coordinators-a-cross-sectional-study-in-china
#1
Ping Mao, Pingping Cai, Aijing Luo, Panhao Huang, Wenzhao Xie
BACKGROUND Organ donation coordinators play an important role in the organ transplantation process. Job burnout can seriously affect their turnover rates and the organ donation rate. The present study investigated the level of job burnout and its related factors among organ donation coordinators in China. MATERIAL AND METHODS From March to May 2017, we administered questionnaire surveys to 320 organ donation coordinators from 32 cities. The questionnaire included the following: the Chinese version of MBI-GS was used to evaluate the burnout levels of organ donation coordinators, the Chinese version of GSES was used to assess related personal factors, and the Job Demands Scale and the SSRS were used to evaluate related environmental factors...
September 14, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30201946/albumin-bilirubin-score-for-predicting-post-transplant-complications-following-adult-to-adult-living-donor-liver-transplantation
#2
Wei Zhang, Chang Liu, Yifei Tan, Lingcan Tan, Li Jiang, Jian Yang, Jiayin Yang, Lunan Yan, Tianfu Wen
BACKGROUND Albumin-Bilirubin (ALBI) grade has been evaluated as an objective method to assess liver function and predict postoperative complications, particularly after hepatectomy in patients with hepatocellular carcinoma (HCC). However, ALBI grade was rarely used in evaluation in living donor liver transplantation (LDLT). MATERIAL AND METHODS Between March 2005 and November 2015, 272 consecutive patients undergoing right-lobe LDLT were enrolled in this study. According to the ALBI score used to evaluate recipients preoperatively, those patients were divided into 3 grades (I, II, and III)...
September 11, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30190449/effect-of-immunosuppressive-therapy-on-the-occurrence-of-atypical-hemolytic-uremic-syndrome-in-renal-transplant-recipients
#3
Rupesh Raina, Abigail Chauvin, Kelli Fox, Natasha Kesav, Mustafa Ascha, Tushar J Vachharajani, Vinod Krishnappa
BACKGROUND Atypical hemolytic uremic syndrome (aHUS), a rare thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Caused by genetic mutations in the alternative complement cascade, aHUS often will culminate in end-stage renal disease and occasionally death. Renal transplantation in aHUS patients has been contraindicated in the past due to the recurrence risk, with certain immunosuppressive regimens being commonly attributed. In this study, we analyzed the association between aHUS and immunosuppressive agents so as to offer evidence for the use of certain immunosuppressive regimens in renal transplant recipients...
September 7, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30177675/pretransplant-qt-interval-the-relationship-with-severity-and-etiology-of-liver-disease-and-prognostic-value-after-liver-transplantation
#4
Renata Główczyńska, Michalina Galas, Urszula Ołdakowska-Jedynak, Michał Peller, Mariusz Tomaniak, Joanna Raszeja-Wyszomirska, Piotr Milkiewicz, Marek Krawczyk, Krzysztof Zieniewicz, Grzegorz Opolski
BACKGROUND Prolonged QT interval is an integral part of the definition of cirrhotic cardiomyopathy. The aim of this study was to analyze the relationship between QT corrected (QTc) and the etiology and the severity of liver disease in relation to the complications of cirrhosis in candidates for orthotropic liver transplantation (OLTx). MATERIAL AND METHODS From 360 consecutive patients with end-stage liver disease (ESLD) consulted by a designated cardiologist, 160 patients underwent OLTx. The QTc was calculated according to 3 formulas in 151 ECG tracings with good quality...
September 4, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30166501/interleukin-17-il-17-induced-mesenchymal-stem-cells-prolong-the-survival-of-allogeneic-skin-grafts
#5
Tengxiao Ma, Xiao Wang, Ya Jiao, Haitao Wang, Yongjun Qi, Hongmin Gong, Longxiao Zhang, Duyin Jiang
BACKGROUND Mesenchymal stem cells (MSCs) have the potential of self-renewal and multi-differentiation and have a wide application prospect in organ transplantation for the effect of inducing immune tolerance. It has found that interleukin 17 (IL-17) could enhance the inhibition effect of MSCs on T cell proliferation and increase the immunosuppressive effect of MSCs. In this study, we aimed to investigate the effect of IL-17-induced MSCs on allograft survival time after transplantation. MATERIAL AND METHODS BMSCs were characterized by differential staining...
August 31, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30150606/catatonia-after-liver-transplantation
#6
Jason R Tatreau, Sarah L Laughon, Tomasz Kozlowski
BACKGROUND Central nervous system complications after transplantation occur in up to 40% of recipients and these complications are associated with increased length of hospital stay and mortality. Catatonia is a neuropsychiatric clinical syndrome which has been described in case reports and in a small case series as occurring in the immediate post-solid organ transplantation (SOT) period, and it has been attributed to calcineurin inhibitor neurotoxicity, psychological vulnerability, and depression. Among transplant recipients, the incidence of catatonia is unknown; it may be under diagnosed in part due to a broad differential diagnosis in the post-transplantation setting, which includes hypoactive delirium, non-convulsive status epilepticus, drug toxicity, conversion disorder, and volitional uncooperativeness...
August 28, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30135417/early-sirolimus-based-immunosuppression-is-safe-for-lung-transplantation-patients-retrospective-single-arm-exploratory-study
#7
Jacek Wojarski, Sławomir Żegleń, Marek Ochman, Wojtek Karolak
BACKGROUND Sirolimus, a mechanistic target of sirolimus inhibitor, is an immunosuppression medication for patients undergoing heart and abdominal transplantation. Sirolimus-based immunosuppression administered de novo post-lung transplantation is associated with bronchial anastomosis healing-related complications. We hypothesized that sirolimus administration within the first postoperative month in selected lung transplant recipients is safe and may be associated with favorable short-term and long-term outcomes due to its anti-proliferative properties and minimal adverse side effects...
August 23, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30127335/the-pre-transplant-profile-of-cardiovascular-risk-factors-and-its-impact-on-long-term-mortality-after-liver-transplantation
#8
Renata Główczyńska, Michalina Galas, Anna Witkowska, Urszula Ołdakowska-Jedynak, Joanna Raszeja-Wyszomirska, Krzysztof Krasuski, Piotr Milkiewicz, Marek Krawczyk, Krzysztof Zieniewicz, Grzegorz Opolski
BACKGROUND Cardiovascular disease (CVD) is an important aggravating factor for orthotopic liver transplantation (OLT) outcomes. CVD still seems to be one of the most common cause of death in the long-term post-transplant period. Nevertheless, there are some limited data regarding the optimal strategy of risk assessment during OLT candidate evaluation. MATERIAL AND METHODS Routine pre-transplant cardiac workup in 360 patients with end stage liver disease (ESLD) included electrocardiogram, echocardiography, and exercise stress testing...
August 21, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30115901/the-efficacy-of-rabbit-anti-thymocyte-globulin-for-acute-kidney-transplant-rejection-in-patients-using-calcineurin-inhibitor-and-mycophenolate-mofetil-based-immunosuppressive-therapy
#9
Marieke van der Zwan, Marian C Clahsen-Van Groningen, Joke I Roodnat, Anne P Bouvy, Casper L Slachmuylders, Willem Weimar, Carla C Baan, Dennis A Hesselink, Marcia M L Kho
BACKGROUND T cell depleting antibody therapy with rabbit anti-thymocyte globulin (rATG) is the treatment of choice for glucocorticoid-resistant acute kidney allograft rejection (AR) and is used as first-line therapy in severe AR. Almost all studies investigating the effectiveness of rATG for this indication were conducted at the time when cyclosporine A and azathioprine were the standard of care. Here, the long-term outcome of rATG for AR in patients using the current standard immunosuppressive therapy (i.e...
August 17, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30104561/gallbladder-pathologies-in-kidney-transplant-recipients-single-center-experience-and-a-review-of-the-literature
#10
Łukasz Dobosz, Jarek Kobiela, Roman Danielewicz, Zbigniew Śledziński, Alicja Dębska-Ślizień
BACKGROUND In patients with end-stage renal disease, cholelithiasis is observed with an increased frequency. In transplant recipients, symptoms might be obscured, which may delay the diagnosis and lead to complications. The aim of our study was to evaluate the frequency of gallbladder pathologies in kidney transplant recipients (KTRs) in the Caucasian population, and to discuss the potential benefits of prophylactic cholecystectomy before kidney transplantation (KT). MATERIAL AND METHODS Data from 434 patients who underwent KT was analyzed...
August 14, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30093607/tacrolimus-granules-for-oral-suspension-as-post-transplant-immunosuppression-in-routine-medical-practice-in-france-the-optimod-study
#11
Florentine Garaix, Marc Stern, François-Xavier Lamy, Laurence Dubel, Nassim Kamar
BACKGROUND Different pharmaceutical forms of oral tacrolimus allow tailored administration. The granular formulation facilitates accurate dose adjustment of tacrolimus according to patient characteristics, such as weight, or potential concomitant drug interactions. Currently, there are no data describing the use of tacrolimus granules in transplant recipients in France. MATERIAL AND METHODS OPTIMOD was a 6-month prospective, observational multicenter study that aimed to describe patient characteristics and conditions of use of tacrolimus granules...
August 10, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30087315/evaluation-of-the-graft-mechanical-function-using-speckle-tracking-echocardiography-during-the-first-year-after-orthotropic-heart-transplantation
#12
Karolina Antończyk, Tomasz Niklewski, Remigiusz Antończyk, Michael Zakliczyński, Marian Zembala, Tomasz Kukulski
BACKGROUND Recent advances in ultrasound strain imaging facilitate more precise monitoring of subtle myocardial changes and thus may allow for more appropriate assessment of myocardium after orthotopic heart transplantation (OHT). This study aimed to explore longitudinal left ventricular (LV) and right ventricular (RV) function by speckle-tracking echocardiography (STE) during a 12-month follow-up period in relation to acute cellular rejection (ACR) degree ≥2R and the response to intense immunosuppressive therapy with intravenous steroids...
August 8, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30082679/evaluation-of-the-learning-curve-of-hand-assisted-laparoscopic-donor-nephrectomy
#13
Bum Sik Tae, Ulanbek Balpukov, Hyeon Hoe Kim, Chang Wook Jeong
BACKGROUND In this study, we analyzed the learning curve of hand-assisted laparoscopic donor nephrectomy (HALDN). MATERIAL AND METHODS The first 198 consecutive donors (110 cases by expert surgeon and 88 cases by newbie surgeon) operated on using HALDN were included in this study. The primary outcome measures were warm ischemic time (WIT), total operation time and estimated blood loss (EBL). The secondary outcome measures included length of hospital stay (LOS), graft outcome, and surgery-related complications...
August 7, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30072683/salvage-liver-transplant-versus-primary-liver-transplant-for-patients-with-hepatocellular-carcinoma
#14
Dipesh Kumar Yadav, Wei Chen, Xueli Bai, Alina Singh, Guogang Li, Tao Ma, Xiazhen Yu, Zhi Xiao, Bingfeng Huang, Tingbo Liang
The strategy of salvage liver transplantation (SLT) originated for initially resectable and transplantable hepatocellular carcinoma (HCC) to preclude upfront transplantation, with SLT in the case of recurrence. However, SLT remains a controversial approach in comparison to primary liver transplant (PLT). The aim of our study was to conduct a systemic review and meta-analysis to assess the short-term outcomes, overall survival (OS), and disease-free survival (DFS) between SLT and PLT for patients with HCC, stratifying results according to the Milan criteria and donor types...
August 3, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30061554/liver-transplantation-for-a-metastatic-pancreatic-solid-pseudopapillary-tumor-frantz-tumor-a-case-report
#15
Michał Wójciak, Jolanta Gozdowska, Marek Pacholczyk, Wojciech Lisik, Maciej Kosieradzki, Andrzej Cichocki, Olga Tronina, Magdalena Durlik
d_abstr_CB Solid-pseudopapillary neoplasms (SPN) of the pancreas, first described by Frantz in 1959, are a very rare entity and account for 0.13-2.7% of all pancreatic neoplasms. They are seen predominantly in young women in their second and third decade of life. d_abstr_CCR We report a case of a 51-year-old female first diagnosed with a pancreatic tumor in 2010 following a computed tomography (CT) scan of the abdomen. The lesion was originally thought to be a neuroendocrine tumor subsequently treated with chemotherapy, which delayed the appropriate treatment...
July 31, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30050031/comparison-of-liver-graft-regeneration-between-abo-compatible-and-abo-incompatible-living-donor-liver-transplantation-a-propensity-score-matching-analysis
#16
Min Suk Chae, Nuri Lee, Ho Joong Choi, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
BACKGROUND ABO-incompatible (ABOi) living donor liver transplantation (LDLT) was accepted as a feasible therapy for end-stage liver disease after the introduction of rituximab. The present study investigated the association between ABO incompatibility and graft regeneration in patients who underwent LDLT. MATERIAL AND METHODS A total of 335 adult patients who underwent elective LDLT were divided into ABO-compatible (ABOc) and ABOi LDLT groups using propensity score (PS) matching of graft regeneration-related factors...
July 27, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30038208/donor-hypernatremia-is-not-related-with-the-duration-of-postoperative-mechanical-ventilation-primary-graft-dysfunction-or-long-term-outcome-following-lung-transplantation
#17
Annemieke Oude Lansink-Hartgring, Lara Hessels, Adrianus J de Vries, Wim van der Bij, Erik A M Verschuuren, Michiel E Erasmus, Maarten W N Nijsten
BACKGROUND Donor hypernatremia has been associated with reduced graft and recipient survival after heart, liver, kidney, and pancreas transplantation. However, it is unknown what effect donor hypernatremia has on graft and recipient outcomes after lung transplantation. The aim of this study was to investigate the relation of donor hypernatremia with the duration of postoperative mechanical ventilation, the incidence of severe primary graft dysfunction, and survival following lung transplantation. MATERIAL AND METHODS We analyzed all consecutive lung transplantations performed in adult patients at our center between 1995 and 2016...
July 24, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30026460/perioperative-telemetric-monitoring-in-pig-to-baboon-heterotopic-thoracic-cardiac-xenotransplantation
#18
Matthias Längin, Alessandro Panelli, Bruno Reichart, Alexander Kind, Paolo Brenner, Tanja Mayr, Jan-Michael Abicht
BACKGROUND Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on the validity of a telemetric system during and after surgery. MATERIAL AND METHODS Wireless telemetry transmitters were implanted in 3 baboons receiving porcine donor hearts. Left ventricular pressure and ECG were assessed from the donor heart, whereas aortic pressure and temperature were assessed from the recipient...
July 20, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30013021/graft-regeneration-and-functional-recovery-in-patients-with-early-allograft-dysfunction-after-living-donor-liver-transplantation
#19
Min Suk Chae, Youngchan Kim, Nuri Lee, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sanghyun Hong
BACKGROUND Successful graft regeneration is important in living-donor liver transplantation (LDLT) because partial liver grafts are used. Early allograft dysfunction (EAD) is an intermediate outcome that affects the long-term postoperative course in liver transplantation. The aim of the present study was to investigate liver graft regeneration under EAD development in LDLT. MATERIAL AND METHODS The data of 226 patients who underwent LDLT from September 2010 to July 2014 were retrospectively analyzed. The patients were classified into 2 groups: one with and one without EAD...
July 17, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30002362/evaluation-of-graft-effluent-high-mobility-group-box-1-hmgb-1-for-prediction-of-outcome-after-liver-transplantation
#20
Philipp Houben, Ralph Hohenberger, Kenya Yamanaka, Markus W Büchler, Peter Schemmer
BACKGROUND Pre-transplant assessment of the graft for liver transplantation is crucial. Based on experimental data, this study was designed to assess both nuclear high mobility group box-1 (HMGB-1) protein and arginine-specific proteolytic activity (ASPA) in the graft effluent. MATERIAL AND METHODS In a non-interventional trial, both HMGB-1 and ASPA were measured in the effluent of 30 liver grafts after cold storage before transplantation. Values of HMGB-1 and ASPA levels were compared with established prognostic parameters such as the donor risk index, balance of risk score, and Donor-Model for End-Stage Liver Disease...
July 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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