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Annals of Transplantation: Quarterly of the Polish Transplantation Society

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https://www.readbyqxmd.com/read/30013021/graft-regeneration-and-functional-recovery-in-patients-with-early-allograft-dysfunction-after-living-donor-liver-transplantation
#1
Min Suk Chae, Youngchan Kim, Nuri Lee, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sanghyun Hong
BACKGROUND Successful graft regeneration is important in living-donor liver transplantation (LDLT) because partial liver grafts are used. Early allograft dysfunction (EAD) is an intermediate outcome that affects the long-term postoperative course in liver transplantation. The aim of the present study was to investigate liver graft regeneration under EAD development in LDLT. MATERIAL AND METHODS The data of 226 patients who underwent LDLT from September 2010 to July 2014 were retrospectively analyzed. The patients were classified into 2 groups: one with and one without EAD...
July 17, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30002362/evaluation-of-graft-effluent-high-mobility-group-box-1-hmgb-1-for-prediction-of-outcome-after-liver-transplantation
#2
Philipp Houben, Ralph Hohenberger, Kenya Yamanaka, Markus W Büchler, Peter Schemmer
BACKGROUND Pre-transplant assessment of the graft for liver transplantation is crucial. Based on experimental data, this study was designed to assess both nuclear high mobility group box-1 (HMGB-1) protein and arginine-specific proteolytic activity (ASPA) in the graft effluent. MATERIAL AND METHODS In a non-interventional trial, both HMGB-1 and ASPA were measured in the effluent of 30 liver grafts after cold storage before transplantation. Values of HMGB-1 and ASPA levels were compared with established prognostic parameters such as the donor risk index, balance of risk score, and Donor-Model for End-Stage Liver Disease...
July 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29987271/neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-predict-acute-cellular-rejection-in-the-kidney-allograft
#3
Mario Naranjo, Akanksha Agrawal, Abhinav Goyal, Janani Rangaswami
BACKGROUND Kidney transplantation is the treatment of choice for end stage kidney disease, but acute rejection remains a limiting factor in optimizing allograft and patient survival. Needle biopsy is the current standard of care for this diagnosis. The potential for complications with repeat biopsies limits the ability to obtain temporal immune surveillance of the allograft. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been shown to be strong predictors of inflammation and of worse prognosis in a variety of conditions...
July 10, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29976918/effect-of-preformed-or-de-novo-anti-hla-antibodies-on-function-and-graft-survival-in-kidney-transplant-recipients
#4
Marcos Vinicius de Sousa, Ana Claudia Gonçalez, Ricardo de Lima Zollner, Marilda Mazzali
BACKGROUND Donor-specific antibodies (DSA), directed against human leucocyte antigens (HLA), are associated with increased risk for graft rejection in kidney transplantation. Anti-HLA antibodies detection by Luminex™ present high sensitivity and accuracy, but its interpretation after transplantation is not completely clear. The aim of this study was to evaluate the impact of anti-HLA antibodies, preformed or de novo, on renal function, graft survival, and incidence of antibody-mediated acute rejection (AMR)...
July 6, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29967315/expanded-criteria-donor-related-hyperkalemia-and-postreperfusion-cardiac-arrest-during-liver-transplantation-a-case-report-and-literature-review
#5
Liang Zhang, Ming Tian, Lin Wei, Zhijun Zhu
BACKGROUND Liver transplantation (LT) using extended criteria donor (ECD) grafts is frequently associated with a high flush fluid potassium concentration (FFK) and acute hyperkalemia after reperfusion, which puts patients at greater risk of postreperfusion cardiac arrest (PRCA). CASE REPORT Herein, we present a case with an extremely high FFK that was successfully pretreated to avoid the risk of PRCA. A 3-year-old boy with biliary atresia underwent LT from a 623-g donation after brain death liver graft with localized frostbite on the right lobe surface...
July 3, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29955032/anti-inflammatory-effect-of-atorvastatin-on-the-kidney-graft-of-living-donor-transplants
#6
Clotilde Fuentes-Orozco, Sara Jazmín Garcia-Salazar, Benjamín Gómez-Navarro, Eduardo González-Espinoza, Alonso Zepeda-González, Juan Narciso Ramírez-Robles, Rafael Castañeda-Espinoza, Irinea Yáñez-Sánchez, Francisco Javier Gálvez-Gastelum, Gabino Cervantes-Guevara, Guillermo Alonso Cervantes-Cardona, Guadalupe Ivette Contreras-Hernández, Jacob Esau Pérez-Landeros, David García-Martinez, Alejandro González-Ojeda
BACKGROUND Recent studies have demonstrated that statins have anti-inflammatory and immunomodulatory properties, which could be considered beneficial in kidney transplantations. This study assesses the anti-inflammatory effect of atorvastatin on the kidney grafts of living donor transplants. MATERIAL AND METHODS In a randomized clinical trial, kidney donors were divided into 2 groups. The study group constituted 24 donors who received 40 mg atorvastatin, and 24 donors who received a placebo control, 4 weeks prior to transplantation...
June 29, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29941863/pancreas-donor-risk-index-but-not-pre-procurement-pancreas-allocation-suitability-score-predicts-pancreas-graft-survival-a-cohort-study-from-a-large-german-pancreas-transplantation-center
#7
Mohamad Samim Ayami, Sascha Grzella, Stylianos Kykalos, Richard Viebahn, Peter Schenker
BACKGROUND The pre-procurement pancreas allocation suitability score (P-PASS) was introduced to support clinical decision-making and ultimately expand the currently insufficient pancreas donor pool. The pancreas donor risk index (PDRI) can be used at the time of organ offering to predict one-year graft survival. Thus, this study aimed to analyze the validity of the PDRI and P-PASS in a large German transplant center. MATERIAL AND METHODS From 2002 to 2015, we performed 327 pancreas transplantations at our center...
June 26, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29930241/t-cell-replete-haploidentical-peripheral-blood-hematopoietic-cell-transplantation-for-treatment-of-t-lymphoblastic-lymphoma
#8
Lixun Guan, Xiaohong Li, Huaping Wei, Zhenyang Gu, Shasha Zhao, Chengying Zhu, Nan Yang, Feiyan Wang, Lan Luo, Zhe Gao, Wenrong Huang, Honghua Li, Quanshun Wang, Daihong Liu, Xiaoxiong Wu, Chunji Gao
BACKGROUND There is currently little information on haploidentical hematopoietic cell transplantation (haplo-HCT) for T-lymphoblastic lymphoma (T-LBL). Data about peripheral blood stem cells (PBSC) as a reliable graft source for T-LBL treatment are lacking. MATERIAL AND METHODS T-LBL patients who underwent T cell-replete haploidentical peripheral blood hematopoietic cell transplantation (haplo-PBHCT) from July 2007 to January 2017 were retrospectively evaluated. RESULTS A total of 25 patients (age ≥15 years) with median age of 24 (range 15-51) years were enrolled...
June 22, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29915167/outcomes-of-induction-therapy-with-rabbit-anti-thymocyte-globulin-in-heart-transplant-recipients-a-single-center-retrospective-cohort-study
#9
Tambi Jarmi, Nirav Patel, Sadaf Aslam, George Makdisi, Elias Doumit, Rahul Mhaskar, Branko Miladinovic, Mark Weston
BACKGROUND Induction immunosuppression is used in transplantation to prevent early acute rejection. The survival benefit of rabbit anti-thymocyte globulin (rATG) induction has not been established yet. We sought to determine the role of rATG in preventing rejection and improving overall survival. MATERIAL AND METHODS A retrospective cohort study was conducted from 2005 to 2009 and data of consecutive 268 heart transplant recipients were reviewed. RESULTS The data of 144 patients who received induction with rATG were compared to 124 patients who did not...
June 19, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29904040/a-pilot-trial-to-examine-the-changes-in-carotid-arterial-inflammation-in-renal-transplant-recipients-as-assessed-by-18f-fluorodeoxyglucose-18f-fdg-positron-emission-tomography-computed-tomography-pet-ct
#10
Hye Eun Yoon, Yaeni Kim, Sang Dong Kim, Jin Kyoung Oh, Yong-An Chung, Seok Joon Shin, Chul Woo Yang, Suk Min Seo
BACKGROUND Inflammatory activity of the artery can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Improvement in vascular function after renal transplantation has been reported, but no studies have used 18F-FDG PET/CT to examine the changes in vascular inflammation. This study investigated the changes in the inflammatory activity in the carotid artery after renal transplantation in patients with chronic kidney disease (CKD). MATERIAL AND METHODS 18F-FDG PET/CT was performed before and at 4 months after transplantation...
June 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29891834/reduced-tacrolimus-trough-level-is-reflected-by-estimated-glomerular-filtration-rate-egfr-changes-in-stable-renal-transplantation-recipients-results-of-the-optimum-phase-3-randomized-controlled-study
#11
Sehoon Park, Yon Su Kim, Jungpyo Lee, Wooseong Huh, Chul Woo Yang, Young-Lim Kim, Yeong Hoon Kim, Joong Kyung Kim, Chang-Kwon Oh, Su-Kil Park
BACKGROUND Minimizing the tacrolimus dosage in patients with stable allograft function needs further investigation. MATERIAL AND METHODS We performed an open-label, randomized, controlled study from 2010 to 2016 in 7 tertiary teaching hospitals in Korea and enrolled 345 kidney transplant recipients with a stable graft status. The study group received reduced-dose tacrolimus, 1080-1440 mg/day of enteric-coated mycophenolate sodium (EC-MPS), and corticosteroids. The control group received the standard tacrolimus dosage and 540-720 mg/day of EC-MPS with steroids...
June 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29880786/serum-caspase-cleaved-cytokeratin-m30-indicates-severity-of-liver-dysfunction-and-predicts-liver-outcome
#12
Hani Oweira, Mahmoud Sadeghi, Daniel Volker, Markus Mieth, Ahmed Zidan, Elias Khajeh, Omid Ghamarnejad, Hamidreza Fonouni, Karl Heinz Weiss, Jan Schmidt, Imad Lahdou, Arianeb Mehrabi
BACKGROUND The Model for End-Stage Liver Disease (MELD) score is a well-established tool for assessing hepatic failure. The present retrospective study investigated whether serum keratin 18 (M65) and caspase-cleaved cytokeratin (M30) were associated with liver dysfunction and post-transplant graft failure. MATERIAL AND METHODS A total of 147 patients with liver cirrhosis were categorized into 2 groups according to their baseline MELD score (group I: MELD score <20, n=87, and group II: MELD score ≥20, n=60)...
June 8, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29867074/willingness-to-consider-increased-risk-donors-a-single-center-experience-in-kidney-transplantation
#13
Vanessa L Richards, Christopher K Johnson, James D Perkins, Ajit P Limaye, Lena Sibulesky
BACKGROUND The number of Public Health Service increased-risk organ donors (PHS IRD) is growing, largely from an increase in intravenous drug use overdoses due to the current opioid epidemic. MATERIAL AND METHODS We conducted a retrospective case series review using our single-center data. We reviewed 82 PHS IRD kidney transplant offers between 2015 and 2017, 20 of which were declined. We reviewed outcomes of patients who declined vs. accepted PHS IRD offers. We studied the effect of education on these patients' willingness to consider another PHS IRD...
June 5, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29853713/retrospective-comparative-study-on-postoperative-pulmonary-complications-after-orthotopic-liver-transplantation-using-the-melbourne-group-scale-mgs-2-diagnostic-criteria
#14
Xiaoyun Li, Chaojin Chen, Xiaoxia Wei, Qianqian Zhu, Weifeng Yao, Dongdong Yuan, Gangjian Luo, Jun Cai, Ziqing Hei
BACKGROUND Postoperative pulmonary complications (PPCs) after orthotopic liver transplantation (OLT) are associated with poor postoperative survival. However, there are no standard criteria for diagnosis of PPCs. This retrospective study aimed to explore the reliability of the Melbourne Group Scale version 2 (MGS-2) for determining PPCs after OLT. MATERIAL AND METHODS A total of 121 patients were divided into 3 groups. In the PPC and non-PPC groups, PPCs were determined to be present or absent in accordance with both the MGS-2 and the conventional broad criteria for diagnosis of PPCs; in the potential-PPC group, PPCs were determined to be present only in accordance with the conventional broad criteria...
June 1, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29807979/impact-of-preoperative-abdominal-visceral-adipose-tissue-area-and-nutritional-status-on-renal-function-after-donor-nephrectomy-in-japanese-living-donors-for-renal-transplantation
#15
Shunta Hori, Makito Miyake, Yosuke Morizawa, Yasushi Nakai, Kenta Onishi, Kota Iida, Daisuke Gotoh, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Tatsuo Yoneda, Nobumichi Tanaka, Katsunori Yoshida, Kiyohide Fujimoto
BACKGROUND Living kidney donors face the risk of renal dysfunction, resulting in end-stage renal disease, cardiovascular disease, or cerebrovascular disease, after donor nephrectomy. Reducing this risk is important to increasing survival of living donors. In this study, we investigated the effect of preoperative distribution of abdominal adipose tissue and nutritional status on postoperative renal function in living donors. MATERIAL AND METHODS Seventy-five living donors were enrolled in this retrospective study...
May 29, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29798972/usefulness-of-pancreas-donor-risk-index-and-pre-procurement-pancreas-allocation-suitability-score-results-of-the-polish-national-study
#16
Kaja Śmigielska, Paweł Skrzypek, Jarosław Czerwiński, Grzegorz Michalak, Marek Durlik, Tadeusz Grochowiecki, Sławomir Nazarewski, Jacek Szmidt, Jacek Ziaja, Robert Król, Lech Cierpka, Wojciech Lisik, Maciej Kosieradzki
BACKGROUND Pre-procurement pancreas suitability score (P-PASS) and pancreas donor risk (PDRI) index are scoring systems believed to predict suitability of pancreatic grafts. Most European countries and the United States apply PDRI, while Poltransplant keeps using P-PASS: more than 16 points raises a red flag for graft use. Recent data discourage use of PDRI to predict pancreas graft survival. The aim of the present study was to assess PDRI and P-PASS as predictors of transplanted pancreas survival in a Polish population...
May 25, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29784902/physician-practice-patterns-and-barriers-to-counselling-on-physical-activity-in-solid-organ-transplant-recipients
#17
Amy Pang, Sarangan Lingham, Weina Zhao, Stephanie Leduc, Agnès Räkel, Ruth Sapir-Pichhadze, Sunita Mathur, Tania Janaudis-Ferreira
BACKGROUND Many solid organ transplant (SOT) recipients fail to meet the recommended physical activity (PA) levels. "Physician recommendation" has previously been reported by SOT recipients as a key facilitator to being more physically active. The purpose of this study was to determine the proportion of Canadian SOT physicians providing PA counselling and identify barriers to including such counselling as part of the SOT recipients' routine care. MATERIAL AND METHODS We conducted a cross-sectional web-based survey study to evaluate physicians' PA counselling practices, including the prevalence and barriers to such practice...
May 22, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29773782/diagnosis-incidence-predictors-and-management-of-postreperfusion-syndrome-in-pediatric-deceased-donor-liver-transplantation-a-single-center-study
#18
Liang Zhang, Ming Tian, Fushan Xue, Zhijun Zhu
BACKGROUND Postreperfusion syndrome (PRS) is a dreadful and well-documented complication in adult liver transplantation (LT). However, information regarding PRS in pediatric LT is still scarce. We aimed to identify the incidence, risk factors and associated outcomes of pediatric LT in a single-center study. MATERIAL AND METHODS The medical records of 75 consecutive pediatric patients who underwent deceased donor liver transplantation (DDLT) from July 2015 to October 2017 were retrospectively reviewed. PRS was determined according to the Peking criteria when significant arrhythmia or refractory hypotension occurred following revascularization of the liver graft...
May 18, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29760372/a-review-of-induction-with-rabbit-antithymocyte-globulin-in-pediatric-heart-transplant-recipients
#19
Martin Schweiger, Andreas Zuckermann, Andres Beiras-Fernandez, Michael Berchtolld-Herz, Udo Boeken, Jens Garbade, Stephan Hirt, Manfred Richter, Arjang Ruhpawar, Jan Dieter Schmitto, Felix Schönrath, Rene Schramm, Uwe Schulz, Markus J Wilhelm, Markus J Barten
Pediatric heart transplantation (pHTx) represents only a small proportion of cardiac transplants. Due to these low numbers, clinical data relating to induction therapy in this special population are far less extensive than for adults. Induction is used more widely in pHTx than in adults, mainly because of early steroid withdrawal or complete steroid avoidance. Antithymocyte globulin (ATG) is the most frequent choice for induction in pHTx, and rabbit antithymocyte globulin (rATG, Thymoglobulin®) (Sanofi Genzyme) is the most widely-used ATG preparation...
May 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29748530/bk-virus-a-cause-for-concern-in-thoracic-transplantation
#20
Markus J Barten, Andreas Zuckermann
Human BK polyomavirus (BKV) infection is poorly documented in heart and lung transplant patients. BK viruria and viremia have been estimated to affect 19% and 5% of heart transplant recipients, respectively. Data are limited, especially for lung transplantation, but the proportion of patients progressing from BK viruria to viremia or BKV-related nephropathy (BKVN) appears lower than in kidney transplantation. Nevertheless, a number of cases of BKVN have been reported in heart and lung transplant patients, typically with late diagnosis and generally poor outcomes...
May 11, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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