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Annals of Transplantation: Quarterly of the Polish Transplantation Society

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https://www.readbyqxmd.com/read/30655498/efficacy-and-safety-of-delayed-prolonged-release-tacrolimus-initiation-in-de-novo-hepatitis-c-virus-negative-orthotopic-liver-transplant-recipients-a-single-center-single-arm-prospective-study
#1
Laura Lladó, Ana González-Castillo, Joan Fabregat, Carme Baliellas, Emilio Ramos, Emma González-Vilatarsana, Juli Busquets, Xavier Xiol
BACKGROUND Delaying initiation of tacrolimus after liver transplantation (LT) is a potential renal-sparing strategy. We assessed safety and efficacy of delayed initiation of prolonged-release tacrolimus (PR-T) in de novo LT. MATERIAL AND METHODS This was a single-center, single-arm, prospective, 12-month observational study of hepatitis C virus-negative orthotopic LT patients. Immunosuppression included PR-T (initially 0.1 or 0.2 mg/kg/day) initiated on Day 3 post LT, basiliximab (20 mg) on post-transplantation Day 0 and Day 4, and intraoperative corticosteroids (500 mg)...
January 18, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30643112/pressurized-intraperitoneal-aerosol-chemotherapy-pipac-for-peritoneal-metastases-in-solid-organ-graft-recipients-first-experience
#2
Philipp Horvath, Can Yurttas, Florian Struller, Hans Bösmüller, Ulrich M Lauer, Silvio Nadalin, Alfred Königsrainer, Marc André Reymond
BACKGROUND Therapy of peritoneal metastases (PM) in solid organ transplant recipients is challenging. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) might constitute a new therapeutic opportunity for these patients. MATERIAL AND METHODS This was a single-center, retrospective analysis of prospective registry data (NCT03210298) in a tertiary care center between 1.7.2016 and 31.12.2017. Intraperitoneal administration of oxaliplatin 92 mg/m² body surface or a combination of cisplatin 7.5 mg/m² and doxorubicin 1...
January 15, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30631030/kidney-transplantation-in-children-with-thrombosed-inferior-caval-vein-atypical-vascular-anastomoses
#3
Marek Szymczak, Piotr Kaliciński, Jacek Rubik, Dorota Broniszczak, Grzegorz Kowalewski, Marek Stefanowicz, Adam Kowalski, Mateusz Ciopiński, Ryszard Grenda
BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. The surgical techniques, complications, patient and graft survival, and long-term renal function were studied retrospectively. The patients' age at transplantation was 2.5-13 years and body mass was 11-39 kg...
January 11, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30617248/pediatric-living-donor-liver-transplant-recipients-without-transition-after-reaching-adulthood
#4
Chikashi Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Masafumi Goto, Michiaki Unno, Takashi Kamei
BACKGROUND Transition to adult care can trigger certain problems for pediatric liver transplant recipients. At our institution, the same transplant team performs both adult and pediatric liver transplantation and post-transplant care; thus, pediatric liver transplant recipients do not have to be transferred. However, it is unclear whether this system affects the recipient's outcome during the transition period. Therefore, we retrospectively assessed pediatric liver transplant recipients who reached adulthood at our institution...
January 8, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30607000/normothermic-machine-perfusion-protects-against-liver-ischemia-reperfusion-injury-during-reduced-size-liver-transplantation-in-pigs
#5
Zhi-Bin Zhang, Wei Gao, Lei Liu, Yuan Shi, Ning Ma, Ming-Sheng Huai, Zhong-Yang Shen
BACKGROUND Normothermic machine perfusion (NMP) preservation is superior to cold preservation during reduced-size liver transplantation (RSLT) in pigs. However, the mechanism of this protective effect has not been explained. We aimed to compare the effects of NMP preservation with that of cold preservation (CS) in protecting against ischemia-reperfusion injury (IRI) during RSLT in pigs. MATERIAL AND METHODS Twenty-four healthy Bama miniature pigs were randomized into 2 groups: 1) the NMP group in which donor livers harvested without warm ischemia time and cardiac activity were connected to the NMP system to reduce liver size under normothermic conditions, and 2) the CS group in which donor livers harvested without warm ischemia time and cardiac activity were perfused using the University of Wisconsin (UW) solution and then preserved in the 0-4°C UW solution to reduce liver size under cold conditions...
January 4, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30598518/somatostatin-therapy-in-patients-with-massive-ascites-after-liver-transplantation
#6
Ting-Ying Lee, Hsiu-Lung Fan, Chia-Wen Wang, Chung-Bao Hsieh, Teng-Wei Chen
BACKGROUND Patients with massive ascites (MA) after liver transplantation (LT, defined here as daily ascitic drainage more than 1000 ml per day for more than 7 days after liver transplantation) are at increased risks of infection, hypoalbuminemia, graft loss, and even mortality. The aim of this retrospective cohort study was to investigate the effects of somatostatin on patients with MA after LT. MATERIAL AND METHODS Twenty-eight patients with liver cirrhosis or hepatocellular carcinoma who underwent LT complicated by MA postoperatively were included...
January 1, 2019: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30587843/feasibility-of-laparoscopic-combined-para-orthotopic-pancreas-and-orthotopic-kidney-transplantation-initial-research-with-a-pig-model
#7
Xiuwu Han, Yongwei Zhao, Bulang He, Xuhui Zhu, Tao Li, Yansheng Li, Peng Zhang, Yuanhao Chen, Gao Li
BACKGROUND The aim of this study was to investigate the feasibility of laparoscopic combined para-orthotopic pancreas and orthotopic kidney transplantation in a pig model. MATERIAL AND METHODS Twelve white female pigs, (4-5 months old, weight range 40-45 kg) were used as donors and recipients, and 6 laparoscopic-combined pancreas and kidney transplantations were performed. After bilateral nephrectomy, the pancreatic artery and vein were anastomosed to the right renal artery and vein, respectively, and the pancreatic fluid was diverted to the duodenum or jejunum...
December 27, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30573723/correlation-between-stem-and-progenitor-cells-number-and-immune-response-in-patients-after-allogeneic-kidney-transplant
#8
Jerzy Sieńko, Maciej Kotowski, Edyta Paczkowska, Anna Sobuś, Karol Tejchman, Jarosław Piątek, Ewa Pilichowska, Karolina Kędzierska-Kapuza, Marek Ostrowski
BACKGROUND Stem and progenitor cells are of great interest in all medical procedures involving tissue regeneration. There is a consensus that the use of stem cells after solid organ transplantation may play a role in tissue repair and in immunosuppression. The aim of this study was to determine possible relations between stem cell count and the immune response in a group of patients after kidney transplantation. MATERIAL AND METHODS The study was conducted on a group of 100 patients who underwent kidney transplantation...
December 21, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30559336/pulmonary-artery-systolic-pressure-measured-intraoperatively-by-right-heart-catheterization-is-a-predictor-of-kidney-transplant-recipient-survival
#9
Tambi Jarmi, Elias Doumit, George Makdisi, Rahul Mhaskar, Branko Miladinovic, Hani Wadei, Mark Rumbak, Sadaf Aslam
BACKGROUND The effect of pulmonary artery systolic pressure (PASP) measured by Swan-Ganz right heart catheter (SG-RHC) on kidney transplant recipient survival has not been previously studied. The objective of this study was to assess the relationships between PASP measured via SG-RHC, done intraoperatively at the time of initiating anesthesia at the beginning of kidney transplant surgery, and patient survival. Multiple comorbidities, time on dialysis before the transplantation, and graft function were also analyzed in our study...
December 18, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30546003/healthcare-resource-use-cost-and-sick-leave-following-kidney-transplantation-in-sweden-a-population-based-5-year-retrospective-study-of-outcomes-coin
#10
Bengt von Zur-Mühlen, Viktor Wintzell, Aaron Levine, Mats Rosenlund, Suzanne Kilany, Sara Nordling, Jonas Wadström
BACKGROUND Improved understanding of the impact of kidney transplantation on healthcare resource use/costs and loss of productivity could aid decision making about funding allocation and resources needed for the treatment of chronic kidney disease in stage 5. MATERIAL AND METHODS This was a retrospective study utilizing data from Swedish national health registers of patients undergoing kidney transplantation. Primary outcomes were renal disease-related healthcare resource utilization and costs during the 5 years after transplantation...
December 14, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30531688/percutaneous-treatment-of-biliary-strictures-after-pediatric-liver-transplantation
#11
Piotr Czubkowski, Malgorzata Markiewicz-Kijewska, Kazimierz Janiszewski, Małgorzata Rurarz, Piotr Kaliciński, Dorota Jarzębicka, Jan Pertkiewicz, Diana Kamińska, Irena Jankowska, Mikołaj Teisseyre, Marek Szymczak, Joanna Pawłowska
BACKGROUND Biliary strictures (BS) are frequent after pediatric liver transplantation (LTx) and in spite of ongoing progress, they remain a significant cause of morbidity. In children, the majority of reconstruction is hepatico-jejunal anastomosis (HJA). The aim of this study was to analyze our experience in percutaneous transhepatic treatment of BS. MATERIAL AND METHODS Between 1998 and 2014, 589 (269 living donor) pediatric LTx were performed in our institution. We retrospectively reviewed clinical data of patients with HJA who developed BS and who underwent percutaneous transhepatic biliary drainage (PTBD)...
December 11, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30523243/success-of-kidney-transplantations-from-deceased-donors-with-acute-kidney-injury
#12
Jana Bauer, Sascha Grzella, Malwina Bialobrzecka, Lea Berger, Timm H Westhoff, Richard Viebahn, Peter Schenker
BACKGROUND The acceptance of organs from deceased donors with acute kidney injury (AKI) varies considerably, with uncertain outcomes. The current organ shortage has led to increased use of marginal donor organs. MATERIAL AND METHODS This retrospective, single-center study included 642 patients who underwent kidney allograft transplantation between 2005 and 2016. The recipients were categorized into 3 groups: AKI-1 (n=214), comprising donors with a peak serum creatinine (SCr) level of 1.1-2.0 mg/dl; AKI-2 (n=89), comprising donors with a peak SCr level >2 mg/dl; and non-AKI (n=339), comprising donors with normal kidney function (SCr <1...
December 7, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30510153/a-single-center-experience-with-an-intensivist-led-brain-dead-donor-management-program
#13
Jin Park, Na Rae Yang, Young-Joo Lee, Kyung Sook Hong
BACKGROUND The aim of this study is to report our experience of brain-dead donor management by a dedicated intensivist who had wide experience in treatment of hemodynamically unstable patient and to suggest a role for intensivists in organ donation. MATERIAL AND METHODS The management of brain-dead donors was performed by experienced intensivists. The hospital medical records and data from the Korean Network of Organ Sharing from August 2013 to December 2016 were reviewed retrospectively. RESULTS Fifty-four brain death patients (3...
December 4, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30478252/evaluation-using-an-isolated-reperfusion-model-for-porcine-liver-donated-after-cardiac-death-preserved-with-oxygenated-hypothermic-machine-perfusion
#14
Ryo Yoshikawa, Naoto Matsuno, Noriyuki Morito, Mikako Gouchi, Masahide Otani, Hiroyuki Takahashi, Tatsuya Shonaka, Yuji Nishikawa, Shin Enosawa, Toshihiko Hirano, Hiroyuki Furukawa, Hiromichi Obara
BACKGROUND Machine perfusion techniques offer a solution to the serious organ shortage. However, to assess the effects of machine perfusion, many detailed studies are required. In this study, an ex vivo reperfusion model using diluted autologous blood was confirmed to evaluate the utility of machine preservation for livers donated after cardiac death (DCD). In particular, beneficial effects of the oxygenated hypothermic machine perfusion (HMP) for DCD porcine livers are evaluated. MATERIAL AND METHODS Porcine livers were procured under warm ischemia time (WIT) of 60 min...
November 27, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30467306/protective-effects-of-apoptosis-of-kupffer-cells-induced-by-zoledronate-liposomes-following-hepatic-ischemia-reperfusion-injury
#15
Qiao-Hong Zhao, Feng Han, Kun Wu, Jie Zhang, Tian-Fang Xia, Jian Chen, Zhen-Shen Qing, Li-Qun Pang
BACKGROUND The goal of this study was to observe the effect of the apoptosis of Kupffer cells (KCs) selectively induced by zoledronate liposomes following the hepatic ischemia-reperfusion injury (IRI) in the rat liver transplantation model and to explore its mechanisms. MATERIAL AND METHODS The rat liver transplantation model was established using the improved Kamada method. Male Sprague Dawley rats were randomly divided into 3 groups: no liver transplantation or drug treatment (Group A); donor rats were injected with 1 mL normal saline through the tail vein for 3 continuous days before transplantation, and the donor liver was preserved in cold for 2 hours (Group B); donor rats were injected with 1 mL zoledronate liposomes (0...
November 23, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30455411/impact-of-donor-pre-procurement-cardiac-arrest-ppca-on-clinical-outcomes-in-liver-transplantation
#16
Richard S Mangus, Joel R Schroering, Jonathan A Fridell, Chandrashekhar A Kubal
BACKGROUND Transplantation of liver grafts from deceased donors who experienced cardiac arrest prior to liver procurement is now common. This single-center study analyzed the impact of pre-donation arrest time on clinical outcomes in liver transplantation. MATERIAL AND METHODS Records of all orthotopic liver transplants performed at a single center over a 15-year period were reviewed. Donor records were reviewed and total arrest time was calculated as cumulative minutes. Post-transplant liver graft function was assessed using laboratory values...
November 20, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30442881/results-of-adult-living-donor-liver-transplantation-with-sixth-decade-donors-a-propensity-score-matching-study-in-a-high-volume-institution
#17
Seok-Hwan Kim, Gil-Chun Park, Shin Hwang, Chul-Soo Ahn, Ki-Hum Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Hwi-Dong Cho, Jae-Hyun Kwon, Yong-Kyu Jung, Su-Min Ha, Sang-Hyun Kang, Sung-Gyu Lee
BACKGROUND We assessed the prognostic impact of donor age on the outcome of adult living donor liver transplantation (LDLT). MATERIAL AND METHODS The study population comprised adult donor and recipients of right lobe grafts for LDLT performed from January 2005 to December 2016. There were 35 living donors aged ≥50 years (old-age donor group). As a control group, donors in their 20s (young-age donor group) were selected after one-to-one propensity score matching based on sex, model for end-stage liver disease (MELD) score, and primary diagnosis...
November 16, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30420590/recurrence-of-hepatitis-b-infection-in-liver-transplant-patients-receiving-long-term-hepatitis-b-immunoglobulin-prophylaxis
#18
Susanne Beckebaum, Kerstin Herzer, Artur Bauhofer, William Gelson, Paolo De Simone, Robert de Man, Cornelius Engelmann, Beat Müllhaupt, Julien Vionnet, Mauro Salizzoni, Riccardo Volpes, Giorgio Ercolani, Luciano De Carlis, Paolo Angeli, Patrizia Burra, Jean-François Dufour, Massimo Rossi, Umberto Cillo, Ulf Neumann, Lutz Fischer, Gabriele Niemann, Luca Toti, Guiseppe Tisone
BACKGROUND Long-term real-world data are relatively sparse regarding recurrence of chronic hepatitis B virus (HBV) infection after liver transplantation using hepatitis B immunoglobulin (HBIg) and nucleos(t)ide analogue (NUC) prophylaxis. MATERIAL AND METHODS Data from 371 adults transplanted for HBV-related disease at 20 European centers and given HBIg for ³12 months ± NUC therapy were analyzed retrospectively. RESULTS HBIg comprised Hepatect® (iv HBIgB; n=299), subcutaneous Zutectra® (sc HBIg, n=236), and other HBIg preparations (n=130); 93...
November 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30409961/colonoscopy-as-part-of-pre-transplant-work-up-in-successful-kidney-transplant-candidates-single-center-experience-and-review-of-literature
#19
Jarek Kobiela, Małgorzata Dobrzycka, Roman Danielewicz, Justyna Jończyk, Andrzej J Łachiński, Zbigniew Śledziński, Alicja Dębska-Ślizień
BACKGROUND Screening colonoscopy is not obligatory in kidney pre-transplant work-up guidelines. According to recommendations, only transplant recipients over age 50 years should be screened. The aim of this study was to characterize endoscopic findings revealed as part of pre-transplant work-up. MATERIAL AND METHODS We retrospectively reviewed pre-transplant work-up charts of 434 adult patients who received a cadaveric donor kidney transplantation (KT) from 2012 to 2015. Endoscopic findings analysis with age subgroup (<50 and ³50) analysis were performed...
November 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/30397188/association-of-kidney-donor-risk-index-with-the-outcome-after-kidney-transplantation-in-the-eurotransplant-senior-program
#20
Beate Schamberger, Dario Lohmann, Daniel Sollinger, Raimund Stein, Jens Lutz
BACKGROUND We evaluated the Kidney Donor Risk Index (KDRI) scoring system for kidney transplantation in the Eurotransplant Senior Program (ESP) that allocates kidneys from older donors to older recipients (≥65 years). MATERIAL AND METHODS We retrospectively analyzed data of 37 kidney transplant recipients and 36 kidney donors who participated in kidney transplantation program according to the ESP at our center from January 2004 until December 2013. RESULTS Mean recipient and donor age was 67.9±2.6 and 70...
November 6, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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