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Critical Care: the Official Journal of the Critical Care Forum

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https://www.readbyqxmd.com/read/30208954/ethical-aspects-of-sudden-cardiac-arrest-research-using-observational-data-a-narrative-review
#1
REVIEW
Marieke A R Bak, Marieke T Blom, Hanno L Tan, Dick L Willems
Sudden cardiac arrest (SCA) accounts for half of all cardiac deaths in Europe. In recent years, large-scale SCA registries have been set up to enable observational studies into risk factors and the effect of treatment approaches. The increasing scale and variety of data sources, coupled with the implementation of a new European data protection legal framework, causes researchers to struggle with how to handle these 'big data'. Data protection in the SCA setting is especially complex since patients become at least temporarily incapacitated, and are thus unable to provide prospective informed consent, and because the majority of patients do not survive...
September 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30205835/massive-increase-in-monocyte-hla-dr-expression-can-be-used-to-discriminate-between-septic-shock-and-hemophagocytic-lymphohistiocytosis-induced-shock
#2
LETTER
Solenn Remy, Morgane Gossez, Alexandre Belot, Jack Hayman, Aurelie Portefaix, Fabienne Venet, Etienne Javouhey, Guillaume Monneret
No abstract text is available yet for this article.
September 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30205826/we-should-avoid-the-term-fluid-overload
#3
EDITORIAL
Jean-Louis Vincent, Michael R Pinsky
No abstract text is available yet for this article.
September 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30196796/women-in-intensive-care-study-a-preliminary-assessment-of-international-data-on-female-representation-in-the-icu-physician-workforce-leadership-and-academic-positions
#4
Bala Venkatesh, Sangeeta Mehta, Derek C Angus, Simon Finfer, Flavia R Machado, John Marshall, Imogen Mitchell, Sandra Peake, Janice L Zimmerman
BACKGROUND: Despite increasing female enrolment into medical schools, persistent gender gaps exist in the physician workforce. There are limited published data on female representation in the critical care medicine workforce. METHODS: To obtain a global perspective, societies (n = 84; 79,834 members (40,363 physicians, 39,471 non-physicians)) registered with the World Federation of Societies of Intensive and Critical Care Medicine were surveyed. Longitudinal data on female trainee and specialist positions between 2006-2017 were obtained from Australia and New Zealand...
September 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30126449/value-of-variation-index-of-inferior-vena-cava-diameter-in-predicting-fluid-responsiveness-in-patients-with-circulatory-shock-receiving-mechanical-ventilation-a-systematic-review-and-meta-analysis
#5
Haijun Huang, Qinkang Shen, Yafen Liu, Hua Xu, Yixin Fang
BACKGROUND: Respiratory variations in the inferior vena cava diameter (ΔIVCD) have been studied extensively with respect to their value in predicting fluid responsiveness, but the results are conflicting. The aim of this meta-analysis was to explore the value of ΔIVCD for predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation. METHODS: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched up to June 2017...
August 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30122152/reassessing-access-to-intensive-care-using-an-estimate-of-the-population-incidence-of-critical-illness
#6
Allan Garland, Kendiss Olafson, Clare D Ramsey, Marina Yogendranc, Randall Fransoo
BACKGROUND: The consistently observed male predominance of patients in intensive care units (ICUs) has raised concerns about gender-based disparities in ICU access. Comparing rates of ICU admission requires choosing a normalizing factor (denominator), and the denominator usually used to compare such rates between subpopulations is the size of those subpopulations. However, the appropriate denominator is the number of people whose medical condition warranted ICU care. We devised an estimate of the number of critically ill people in the general population, and used it to compare rates of ICU admission by gender and income...
August 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30122149/predicting-the-requirement-for-renal-replacement-therapy-in-intensive-care-patients-with-sepsis
#7
LETTER
Axel Nierhaus, Frank Bloos, Darius Cameron Wilson, Gunnar Elke, Patrick Meybohm
No abstract text is available yet for this article.
August 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30121090/investigation-of-microcirculation-in-patients-with-venoarterial-extracorporeal-membrane-oxygenation-life-support
#8
Yu-Chang Yeh, Chen-Tse Lee, Chih-Hsien Wang, Yu-Kang Tu, Chien-Heng Lai, Yin-Chin Wang, Anne Chao, Chi-Hsiang Huang, Ya-Jung Cheng, Yih-Sharng Chen
BACKGROUND: Microcirculatory dysfunction develops in both septic and cardiogenic shock patients, and it is associated with poor prognosis in patients with septic shock. Information on the association between microcirculatory dysfunction and prognosis in cardiogenic shock patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is limited. METHODS: Sublingual microcirculation images were recorded using an incident dark-field video microscope at the following time points: within 12 h (T1), 24 h (T2), 48 h (T3), 72 h (T4), and 96 h (T5) after VA-ECMO placement...
August 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30121088/feasibility-of-biventricular-3d-transthoracic-echocardiography-in-the-critically-ill-and-comparison-with-conventional-parameters
#9
Sam Orde, Michel Slama, Nicola Stanley, Stephen Huang, Anthony Mclean
BACKGROUND: Transthoracic 3D cardiac analysis is enticing in its potential simplicity and wealth of data available. It has been suggested to be accurate vs magnetic resonance imaging in relatively stable patients, but feasibility and agreement with conventional echocardiographic assessment of stroke volume (SV) have not been thoroughly assessed in critically ill patients, who are traditionally harder to image. The objectives of this study were to compare 3D transthoracic volumetric analysis vs Doppler assessment of SV (which is suggested to be accurate in the critically ill) and Simpson's biplane assessment in a cohort typical of the intensive care unit (ICU), where accurate assessment is important: mechanically ventilated patients with a significant ventilation/perfusion (V/Q) mismatch...
August 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30121083/predictors-of-insufficient-peak-amikacin-concentration-in-critically-ill-patients-on-extracorporeal-membrane-oxygenation
#10
Cyril Touchard, Alexandra Aubry, Philippine Eloy, Nicolas Bréchot, Guillaume Lebreton, Guillaume Franchineau, Sebastien Besset, Guillaume Hékimian, Ania Nieszkowska, Pascal Leprince, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
BACKGROUND: Amikacin infusion requires targeting a peak serum concentration (Cmax ) 8-10 times the minimal inhibitory concentration, corresponding to a Cmax of 60-80 mg/L for the least susceptible bacteria to theoretically prevent therapeutic failure. Because drug pharmacokinetics on extracorporeal membrane oxygenation (ECMO) are challenging, we undertook this study to assess the frequency of insufficient amikacin Cmax in critically ill patients on ECMO and to identify relative risk factors...
August 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30121080/loop-diuretic-use-in-patients-with-aki-different-severity-different-response
#11
LETTER
Yanfei Shen, Muying Wu
No abstract text is available yet for this article.
August 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30119692/carbon-dioxide-dynamics-in-relation-to-neurological-outcome-in-resuscitated-out-of-hospital-cardiac-arrest-patients-an-exploratory-target-temperature-management-trial-substudy
#12
Florian Ebner, Matt B A Harmon, Anders Aneman, Tobias Cronberg, Hans Friberg, Christian Hassager, Nicole Juffermans, Jesper Kjærgaard, Michael Kuiper, Niklas Mattsson, Paolo Pelosi, Susann Ullén, Johan Undén, Matt P Wise, Niklas Nielsen
BACKGROUND: Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined. METHODS: This is an exploratory post-hoc substudy of the Target Temperature Management (TTM) trial, including resuscitated OHCA patients, investigating the association between serial measurements of arterial partial carbon dioxide pressure (PaCO2 ) and neurological outcome at 6 months, defined by the Cerebral Performance Category (CPC) scale, dichotomized to good outcome (CPC 1 and 2) and poor outcome (CPC 3-5)...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30119691/predicting-acute-kidney-injury-using-urinary-liver-type-fatty-acid-binding-protein-and-serum-n-terminal-pro-b-type-natriuretic-peptide-levels-in-patients-treated-at-medical-cardiac-intensive-care-units
#13
Hiroyuki Naruse, Junnichi Ishii, Hiroshi Takahashi, Fumihiko Kitagawa, Hideto Nishimura, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Akira Yamada, Sadako Motoyama, Shigeru Matsui, Mutsuharu Hayashi, Masayoshi Sarai, Eiichi Watanabe, Hideo Izawa, Yukio Ozaki
BACKGROUND: The early prediction of acute kidney injury (AKI) can facilitate timely intervention and prevent complications. We aimed to understand the predictive value of urinary liver-type fatty-acid binding protein (L-FABP) levels on admission to medical (non-surgical) cardiac intensive care units (CICUs) for AKI, both independently and in combination with serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. METHODS: We prospectively investigated the predictive value of L-FABP and NT-proBNP for AKI in a large, heterogeneous cohort of patients treated in medical CICUs...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30119687/chest-radiography-versus-lung-ultrasound-for-identification-of-acute-respiratory-distress-syndrome-a-retrospective-observational-study
#14
Kay Choong See, Venetia Ong, Yi Lin Tan, Juliet Sahagun, Juvel Taculod
BACKGROUND: Lung ultrasound may be a reasonable alternative to chest radiography for the identification of acute respiratory distress syndrome (ARDS), but the diagnostic performance of lung ultrasound for ARDS is uncertain. We therefore analyzed the clinical outcomes of ARDS diagnosed according to the Berlin Definition, using either chest radiography (Berlin-CXR) or lung ultrasound (Berlin-LUS) as an alternative imaging method. METHODS: This was a retrospective observational study in a 20-bed medical intensive care unit (ICU)...
August 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30119699/histidine-rich-glycoprotein-as-an-excellent-biomarker-for-sepsis-and-beyond
#15
EDITORIAL
Masahiro Nishibori, Hidenori Wake, Hiroshi Morimatsu
Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30119686/functional-outcomes-in-adults-with-tuberculous-meningitis-admitted-to-the-icu-a-multicenter-cohort-study
#16
Marie Cantier, Adeline Morisot, Emmanuel Guérot, Bruno Megarbane, Keyvan Razazi, Damien Contou, Eric Mariotte, Emmanuel Canet, Etienne De Montmollin, Vincent Dubée, Eric Boulet, Stéphane Gaudry, Guillaume Voiriot, Julien Mayaux, Frédéric Pène, Mathilde Neuville, Bruno Mourvillier, Stéphane Ruckly, Lila Bouadma, Michel Wolff, Jean-François Timsit, Romain Sonneville
BACKGROUND: Tuberculous meningitis (TBM) is a devastating infection in tuberculosis endemic areas with limited access to intensive care. Functional outcomes of severe adult TBM patients admitted to the ICU in nonendemic areas are not known. METHODS: We conducted a retrospective multicenter cohort study (2004-2016) of consecutive TBM patients admitted to 12 ICUs in the Paris area, France. Clinical, biological, and brain magnetic resonance imaging (MRI) findings at admission associated with a poor functional outcome (i...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30115127/epidemiology-and-patterns-of-tracheostomy-practice-in-patients-with-acute-respiratory-distress-syndrome-in-icus-across-50-countries
#17
Toshikazu Abe, Fabiana Madotto, Tài Pham, Isao Nagata, Masatoshi Uchida, Nanako Tamiya, Kiyoyasu Kurahashi, Giacomo Bellani, John G Laffey
BACKGROUND: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. METHODS: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30115108/hemodynamic-management-of-critically-ill-burn-patients-an-international-survey
#18
LETTER
Sabri Soussi, Mette M Berger, Kirsten Colpaert, Martin W Dünser, Anne Berit Guttormsen, Nicole P Juffermans, Paul Knape, Guniz Koksal, Athina Lavrentieva, Thomas Leclerc, José A Lorente, Ignacio Martin-Loeches, Philipp Metnitz, Olivier Pantet, Paolo Pelosi, Anne-Françoise Rousseau, Folke Sjöberg, Matthieu Legrand
No abstract text is available yet for this article.
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30115103/intravenous-ivabradine-versus-placebo-in-patients-with-low-cardiac-output-syndrome-treated-by-dobutamine-after-elective-coronary-artery-bypass-surgery-a-phase-2-exploratory-randomized-controlled-trial
#19
Lee S Nguyen, Pierre Squara, Julien Amour, Daniel Carbognani, Kamel Bouabdallah, Stéphane Thierry, Caroline Apert-Verneuil, Aurélie Moyne, Bernard Cholley
BACKGROUND: Low cardiac output syndrome (LCOS) is a severe condition which can occur after cardiac surgery, especially among patients with pre-existing left ventricular dysfunction. Dobutamine, its first-line treatment, is associated with sinus tachycardia. This study aims to assess the ability of intravenous ivabradine to decrease sinus tachycardia associated with dobutamine infused for LCOS after coronary artery bypass graft (CABG) surgery. METHODS: In a phase 2, multi-center, single-blind, randomized controlled trial, patients with left ventricular ejection fraction below 40% presenting sinus tachycardia of at least 100 beats per minute (bpm) following dobutamine infusion for LCOS after CABG surgery received either intravenous ivabradine or placebo (three ivabradine for one placebo)...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30115067/efficacy-of-polymyxin-b-hemoperfusion-in-and-beyond-septic-shock-is-an-endotoxin-severity-score-needed
#20
LETTER
Patrick M Honore, David De Bels, Thierry Preseau, Sebastien Redant, Herbert D Spapen
No abstract text is available yet for this article.
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
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