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Critical Care: the Official Journal of the Critical Care Forum

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https://www.readbyqxmd.com/read/30409197/ultrasound-guided-vessel-puncture-calling-for-pythagoras-help
#1
EDITORIAL
Gaël Piton, Gilles Capellier, Hadrien Winiszewski
No abstract text is available yet for this article.
November 8, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30390690/is-access-to-intensive-care-equitable
#2
EDITORIAL
Claudio M Martin
No abstract text is available yet for this article.
November 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30382926/angiotensin-in-ecmo-patients-with-refractory-shock
#3
LETTER
Marlies Ostermann, David W Boldt, Michael D Harper, George W Lim, Kyle Gunnerson
No abstract text is available yet for this article.
November 1, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30382905/clinical-benefit-of-high-volume-hemofiltration-in-severe-burn-injury-is-it-removing-bad-humors-or-actually-avoiding-hypervolemia
#4
LETTER
Patrick M Honore, David De Bels, Thierry Preseau, Sebastien Redant, Rachid Attou, Andrea Gallerani, Herbert D Spapen
No abstract text is available yet for this article.
November 1, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30382866/delay-in-antibiotic-therapy-results-in-fatal-disease-outcome-in-murine-pneumococcal-pneumonia
#5
Sarah Berger, Cengiz Goekeri, Shishir K Gupta, Julio Vera, Kristina Dietert, Ulrike Behrendt, Jasmin Lienau, Sandra-Maria Wienhold, Achim D Gruber, Norbert Suttorp, Martin Witzenrath, Geraldine Nouailles
BACKGROUND: Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully understood. METHODS: To model timely versus delayed antibiotic therapy in patients, mice with pneumococcal pneumonia received ampicillin twice a day starting early (24 h) or late (48 h) after infection. Clinical readouts and local and systemic inflammatory mediators after early and late antibiotic intervention were examined...
November 1, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30382863/optimizing-micafungin-dosing-in-critically-ill-patients-what-about-extracorporeal-therapies
#6
LETTER
Patrick M Honore, David De Bels, Leonel Barreto Gutierrez, Sebastien Redant, Rachid Attou, Andrea Gallerani, Herbert D Spapen
No abstract text is available yet for this article.
November 1, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373675/development-and-internal-validation-of-the-multivariable-cipher-collaborative-integrated-pregnancy-high-dependency-estimate-of-risk-clinical-risk-prediction-model
#7
Beth A Payne, Helen Ryan, Jeffrey Bone, Laura A Magee, Alice B Aarvold, J Mark Ansermino, Zulfiqar A Bhutta, Mary Bowen, J Guilherme Cecatti, Cynthia Chazotte, Tim Crozier, Anne-Cornélie J M de Pont, Oktay Demirkiran, Tao Duan, Marlot Kallen, Wessel Ganzevoort, Michael Geary, Dena Goffman, Jennifer A Hutcheon, K S Joseph, Stephen E Lapinsky, Isam Lataifeh, Jing Li, Sarka Liskonova, Emily M Hamel, Fionnuala M McAuliffe, Colm O'Herlihy, Ben W J Mol, P Gareth R Seaward, Ramzy Tadros, Turkan Togal, Rahat Qureshi, U Vivian Ukah, Daniela Vasquez, Euan Wallace, Paul Yong, Vivian Zhou, Keith R Walley, Peter von Dadelszen
BACKGROUND: Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations is contentious. The aim of the CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) study was to develop and internally validate a multivariable prognostic model calibrated specifically for pregnant or recently delivered women admitted for critical care...
October 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373653/multicenter-derivation-and-validation-of-an-early-warning-score-for-acute-respiratory-failure-or-death-in-the-hospital
#8
Mikhail A Dziadzko, Paul J Novotny, Jeff Sloan, Ognjen Gajic, Vitaly Herasevich, Parsa Mirhaji, Yiyuan Wu, Michelle Ng Gong
BACKGROUND: Acute respiratory failure occurs frequently in hospitalized patients and often starts before ICU admission. A risk stratification tool to predict mortality and risk for mechanical ventilation (MV) may allow for earlier evaluation and intervention. We developed and validated an automated electronic health record (EHR)-based model-Accurate Prediction of Prolonged Ventilation (APPROVE)-to identify patients at risk of death or respiratory failure requiring >= 48 h of MV...
October 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373638/early-therapeutic-plasma-exchange-in-septic-shock-a-prospective-open-label-nonrandomized-pilot-study-focusing-on-safety-hemodynamics-vascular-barrier-function-and-biologic-markers
#9
Hannah Knaup, Klaus Stahl, Bernhard M W Schmidt, Temitayo O Idowu, Markus Busch, Olaf Wiesner, Tobias Welte, Hermann Haller, Jan T Kielstein, Marius M Hoeper, Sascha David
BACKGROUND: Given the pathophysiological key role of the host response to an infection rather than the infection per se, an ideal therapeutic strategy would also target this response. This study was designed to demonstrate safety and feasibility of early therapeutic plasma exchange (TPE) in severely ill individuals with septic shock. METHODS: This was a prospective single center, open-label, nonrandomized pilot study enrolling 20 patients with early septic shock (onset < 12 h) requiring high doses of norepinephrine (NE; > 0...
October 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373623/hyperchloremia-and-postoperative-acute-kidney-injury-a-retrospective-analysis-of-data-from-the-surgical-intensive-care-unit
#10
Tak Kyu Oh, In-Ae Song, Se Joong Kim, Sung Yoon Lim, Sang-Hwan Do, Jung-Won Hwang, Jinhee Kim, Young-Tae Jeon
BACKGROUND: Whether perioperative hyperchloremia can induce postoperative acute kidney injury (AKI) is controversial. We investigated the association between perioperative hyperchloremia and postoperative AKI in patients admitted to the intensive care unit (ICU) after surgery. METHODS: We performed a retrospective observational study of patients admitted to the surgical ICU at a single tertiary care hospital between January 2011 and June 2016. Our primary objective was to determine whether hyperchloremia or an increase in serum chloride levels was associated with postoperative AKI...
October 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373656/microcirculation-in-cardiogenic-shock-supported-with-extracorporeal-membrane-oxygenation-the-need-for-a-homogeneous-population-and-strict-evolution-assessment
#11
LETTER
Santiago Montero, Juliette Chommeloux, Guillaume Franchineau, Alain Combes, Matthieu Schmidt
No abstract text is available yet for this article.
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373648/the-global-need-for-essential-emergency-and-critical-care
#12
Carl Otto Schell, Martin Gerdin Wärnberg, Anna Hvarfner, Andreas Höög, Ulrika Baker, Markus Castegren, Tim Baker
Critical illness results in millions of deaths each year. Care for those with critical illness is often neglected due to a lack of prioritisation, co-ordination, and coverage of timely identification and basic life-saving treatments. To improve care, we propose a new focus on essential emergency and critical care (EECC)-care that all critically ill patients should receive in all hospitals in the world. Essential emergency and critical care should be part of universal health coverage, is appropriate for all countries in the world, and is intended for patients irrespective of age, gender, underlying diagnosis, medical specialty, or location in the hospital...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373647/ascorbic-acid-corticosteroids-and-thiamine-in-sepsis-a-review-of-the-biologic-rationale-and-the-present-state-of-clinical-evaluation
#13
REVIEW
Ari Moskowitz, Lars W Andersen, David T Huang, Katherine M Berg, Anne V Grossestreuer, Paul E Marik, Robert L Sherwin, Peter C Hou, Lance B Becker, Michael N Cocchi, Pratik Doshi, Jonathan Gong, Ayan Sen, Michael W Donnino
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, we describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated the drug combination in patients with severe infection...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30373626/ventilator-induced-lung-injury-is-aggravated-by-antibiotic-mediated-microbiota-depletion-in-mice
#14
Sandra-Maria Wienhold, Mario Macrì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath, Holger C Müller-Redetzky
BACKGROUND: Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether disruption of the microbiota by antibiotic therapy prior to mechanical ventilation affects pulmonary inflammatory responses and thereby the development of VILI...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30371345/carbonic-anhydrase-inhibitors-in-patients-with-respiratory-failure-and-metabolic-alkalosis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl, Houssam S Itani
BACKGROUND: Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis. The objective of this systematic review is to assess the benefits and harms of carbonic anhydrase inhibitor therapy in patients with respiratory failure and metabolic alkalosis. METHODS: We searched the following electronic sources from inception to August 2017: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and SCOPUS...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30371341/vitamin-d-deficiency-and-supplementation-in-critical-illness-the-known-knowns-and-known-unknowns
#16
REVIEW
Priya Nair, Balasubramaniam Venkatesh, Jacqueline R Center
The burgeoning literature on vitamin D deficiency and supplementation over the past decade or so has generated a greater understanding of some areas but also an appreciation of the many areas of equipoise. This is particularly relevant in the field of critical care with the heterogeneous patient populations, the severity and duration of illness and the frequency of comorbid conditions.This review aims to summarise the current knowledge base of vitamin D deficiency within the context of critical illness-"the known knowns"-and also highlight the areas of recognised uncertainty-"the known unknowns"...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30368249/can-probiotics-be-an-alternative-to-chlorhexidine-for-oral-care-in-the-mechanically-ventilated-patient-a-multicentre-prospective-randomised-controlled-open-trial
#17
Bengt Klarin, Anne Adolfsson, Anders Torstensson, Anders Larsson
BACKGROUND: Pathogenic enteric bacteria aspirated from the oropharynx are the main cause of ventilator-associated pneumonia (VAP). Using chlorhexidine (CHX) orally or selective decontamination has been shown to reduce VAP. In a pilot study we found that oral care with the probiotic bacterium Lactobacillus plantarum 299 (Lp299) was as effective as CHX in reducing enteric bacteria in the oropharynx. To confirm those results, in this expanded study with an identical protocol we increased the number of patients and participating centres...
October 28, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30368243/angiotensin-converting-enzyme-defects-in-shock-implications-for-future-therapy
#18
Lakhmir S Chawla, Steve Chen, Rinaldo Bellomo, George F Tidmarsh
No abstract text is available yet for this article.
October 28, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30368239/determinants-of-sepsis-knowledge-a-representative-survey-of-the-elderly-population-in-germany
#19
Sarah Eitze, Carolin Fleischmann-Struzek, Cornelia Betsch, Konrad Reinhart
BACKGROUND: Sepsis is a life-threatening medical emergency requiring early diagnosis and urgent treatment. Knowledge is crucial, especially in major risk groups such as the elderly. We therefore assessed sophisticated knowledge about sepsis in the German elderly population. METHODS: A telephone survey was carried out with a representative sample of 701 Germans from 16 federal states and a separate cohort of 700 participants from Thuringia, all aged ≥ 60 years...
October 28, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30367670/identifying-associations-between-diabetes-and-acute-respiratory-distress-syndrome-in-patients-with-acute-hypoxemic-respiratory-failure-an-analysis-of-the-lung-safe-database
#20
Andrew J Boyle, Fabiana Madotto, John G Laffey, Giacomo Bellani, Tài Pham, Antonio Pesenti, B Taylor Thompson, Cecilia M O'Kane, Adam M Deane, Daniel F McAuley
BACKGROUND: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). METHODS: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken...
October 27, 2018: Critical Care: the Official Journal of the Critical Care Forum
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