M Maezawa, M Inoue, R Satake, W Wakabayashi, K Oura, F Goto, K Miyasaka, S Hirofuji, M Iwata, T Suzuki, H Tanaka, S Nishida, S Shimizu, A Suzuki, K Iguchi, M Nakamura
Objective : Magnesium oxide is widely used for treating opioid-induced constipation, a serious analgesic-associated problem. Opioid analgesic users are often prescribed non-steroidal anti-inflammatory drugs, which are sometimes combined with acid suppressants to prevent gastrointestinal adverse events. Magnesium preparations combined with acid suppressants may diminish magnesium preparations' laxative effect. This study was aimed at evaluating the effect of magnesium preparations combined with acid suppressants on the incidence of opioid-induced constipation by using the Food and Drug Administration Adverse Event Reporting System...
December 4, 2023: Die Pharmazie