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Die Pharmazie

G A Petroianu, A Stegmeier-Petroianu, D E Lorke
Cleopatra VII (69-30 BC), the last Ptolemaic ruler of Egypt, is probably best known for her love affairs with Julius Caesar (100-44 BC) and Marcus Antonius (83-30 BC). Rightly or wrongly she became the epitome of shrewd seduction, leading brave Roman commanders on a path to debauchery and destruction. Among the seductive strategies attributed to her is the ingestion of small amounts of turpentine [the resin of the terebinth tree ( Pistacia terebinthus )] or of derived oil ( Oleum terebinthinae ) with the purpose of conferring to her urine a more pleasant scent reminding of violets...
November 1, 2018: Die Pharmazie
M Nishihara, N Morikawa, S Yokoyama, K Nishikura, M Yasuhara, H Matsuo
Bevacizumab has been reported to increase blood pressure. However, the factors, including patient characteristics and laboratory data contributing to this side effect remain unclear. Therefore, we investigated the relationships between increased blood pressure and bevacizumab administration, patient characteristics, and laboratory data. Between April 2007 and January 2018, factor analysis was retrospectively conducted by monitoring increases in blood pressure, the status of bevacizumab administration, patient characteristics, and laboratory data before the first administration in Japanese patients with colorectal cancer who satisfied the criteria for this study...
November 1, 2018: Die Pharmazie
Sijing Dong, Jianbo Ji, Baofang Zhang, Lingyun Hu, Xiangzhen Cui, Haina Wang
Hovenia dulcis Thunb. is a traditional hepatoprotective Chinese medicine, and in research, much effort has been focused on the protection against alcoholic liver injury. In this study, the protective effects of a fruit ethanol extract of Hovenia dulcis (FE) against APAP-induced acute hepatotoxicity in mice and the possibly involved molecular mechanisms were investigated. Hepatoprotective activity of FE is clearly indicated by histopathological and biochemical examination. Treatment with FE resulted in inhibition of CYP2E1 activity involved in the transformation of APAP in vivo ...
November 1, 2018: Die Pharmazie
Peng Guo, Shengjie Kang, Feifei Zhao
Background: YAP/TAZ have been reported to be highly expressed in malignant tumors. This research was aimed to study the expression of TAZ/YAP protein in malignant melanoma and to investigate its relationship to the clinicopathology and prognosis of patients with malignant melanoma. Methods: A total of 156 pairs of malignant melanoma tumor tissues and melanocytic nevi tissues were collected. The expression of TAZ and YAP proteins were detected by immunohistochemistry and western blotting. Relationship between TAZ/YAP and clinical data of malignant melanoma were analyzed...
November 1, 2018: Die Pharmazie
Y Domon, Y Kitano, M Makino
Mirogabalin, which is a novel ligand for the α₂δ subunit of voltage-gated calcium channels, is under development for the treatment of pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Mirogabalin possesses unique binding characteristics to α₂δ subunits and potent and long-lasting analgesic effects in peripheral neuropathic pain models. In the present study, we investigated the analgesic effects of mirogabalin in a rat model of spinal cord injury as an experimental animal model for central neuropathic pain...
November 1, 2018: Die Pharmazie
Huiyan Deng, Huaping Li, Zi Yin Ho, Xin Yue Dai, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Aim: The aim of this study was to further elucidate the mechanism of pterostilbene against UVA/UVB irradiation and the Nuclear factor E2-related factor 2 (Nrf2) signal pathway. Methods: A photo-damage model with UVA/UVB irradiation in HaCat cells was established and used in this study. The dose of pterostilbene was selected through MTS assay. Cell proliferation and apoptosis in Nrf2 and knockdown Nrf2 cells was detected by MTS assay. Expression of CAT, HO-1, and SOD in Nrf2 and knockdown Nrf2 cells was explored by qPCR...
November 1, 2018: Die Pharmazie
Zhao Xinyan, Zhang Xuekang, Liang Sisi, Fang Xinhua, Shu Shi, Liu Zhiyi
Objective: The study observed the efficacy and safety of dexmedetomidine, propofol and etomidate on brain functional areas in patients undergoing wake-up brain surgery under the guidance of entropy index. Methods: Sixty patients undergoing wake-up brain surgery on brain functional areas were enrolled, and randomly divided into three groups: dexmedetomidine group (group D), propofol group (group P) and etomidate group (group E), 20 in each. The vital signs, entropy indices of each time point, wake-up time, wake-up quality and adverse reaction in the wake-up period were observed and compared...
November 1, 2018: Die Pharmazie
(no author information available yet)
Levetiracetam (LEV) is an anti-epileptic drug with demonstrated efficacy against generalized seizures. Recent studies have found that LEV affects the release of neurotransmitters by binding to synaptic vesicle protein 2A (SV2A). However, the details of LEV regulation of synaptic transmission remain poorly understood. Here, we used the whole-cell patch-clamp technique to further characterize the effects of LEV on synaptic transmission at a large mammalian central synapse, the calyx of Held. Our results showed that two common forms of vesicle endocytosis, including slow and rapid endocytosis, were dramatically inhibited when slices were incubated in 100 μM LEV for 1 h, however, the action potential (AP), calcium influx and exocytosis were not affected...
November 1, 2018: Die Pharmazie
A Belal
The aim of this work was to investigate the biomolecular targets for a library of indolizines, study their molecular properties, drug likeness, target prediction, performing docking studies and exploring their ADMET profile in search for a lead compound. All compounds appeared to comply with Lipinski's rule without any violation, additionally their solubility is viewed good except for compounds 4a-c which are anticipated to be reasonably soluble, their Milog P score was 4.18-4.9, proposing that these compounds are the most lipophilic with least water solubility, however this may be helpful as the cannabinoid receptor-1 is the most probable target for these three compounds...
November 1, 2018: Die Pharmazie
Handeng Lv, Enzhao Shen, Lu Luo, Yong Xu, Yaqian Pan, Kaiqi Wu, Zhicheng Xing, Faqing Ye, Yuan Zhang
EAI045 represents a fourth generation allosteric EGFR TKI compound which targets T790M and C797S EGFR mutants. The study reported herein describes a method to explore the distribution of EAI045 in rat tissues as well as to quantify it in plasma. The method used here is an ultra-performance liquid chromatography-tandem mass spectrometry with high sensitivity and selectivity. An ACQUITY UPLC BEN HILIC column with dimensions of 2.1 × 100 mm, 1.7 μm was used to separate the analytes and IS. As mobile phase acetonitrile as well as 0...
November 1, 2018: Die Pharmazie
W Wichitnithad, T Kiatkumjorn, P Jithavech, P Thanawattanawanich, P Ratnatilaka Na Bhuket, P Rojsitthisak
A simple sample preparation technique coupled with the specific and sensitive fluorescence detection for the determination of moxifloxacin in human plasma was developed and fully validated. Levofloxacin was chosen as an internal standard. Chromatographic separation was achieved using a Shiseido C18 MGII (250×4.6mm i.d.; 5 μm) column under an isocratic mobile phase comprising of 50 mM potassium dihydrogen phosphate (pH 2.4) - acetonitrile (77:23, v/v) at a flow rate of 1.5 mL/min. Fluorescence detection was optimized for the determination of moxifloxacin in human plasma at an excitation wavelength of 296 nm and an emission wavelength of 504 nm...
November 1, 2018: Die Pharmazie
B Sienkiewicz-Oleszkiewicz, A Wiela-Hojeńska
Purpose : The CYP2C19 isoenzyme plays an important role in the efficacy and safe use of many drugs. The aim of this review is to demonstrate how CYP2C19 mutations influence everyday patient treatment, leading to adverse drug reactions or therapy failure in many common diseases. Methods : A PubMed literature search was performed on clinical publications evaluating the impact of CYP2C19 on pharmacotherapy outcome. Main fields of medicine with strong outcome dependency on the CYP2C19 genotype were selected. We also focused on clinical recommendations for the use of drugs referring to CYP2C19 polymorphism...
November 1, 2018: Die Pharmazie
Y Yoshida, K Komori, M Aoki, M Sandou, M Takagi, E Uejima
Chemotherapy is among the standard treatments for esophageal cancer. The docetaxel, 5-fluorouracil, and cisplatin (DCF) protocol yields a better response rate than 5-fluorouracil plus cisplatin. However, the incidence of side effects, such as febrile neutropenia and hematologic toxicity, is also significantly high with the DCF protocol. The granulocyte colony-stimulating factor and pegfilgrastim are prophylactically administered to prevent febrile neutropenia. This retrospective study evaluated the efficacy and safety of pegfilgrastim in patients receiving DCF therapy...
October 1, 2018: Die Pharmazie
Y Tominaga, T Aomori, T Hayakawa, D E Morisky, K Takahashi, M Mochizuki
A cross-sectional survey of 358 patients was conducted among type 2 diabetes patients recruited at medical institutions or via an online research company. Medication adherence was measured using the 8-item Morisky Medication Adherence Scale (MMAS-8). Univariate and multivariate regression analyses of glycosylated hemoglobin (HbA1c) were performed in addition to assessing demographic and disease characteristics and MMAS-8. In conclusion, medication adherence as measured by the MMAS-8 score independently contributes to altering the HbA1c level in the range of 1...
October 1, 2018: Die Pharmazie
M P Neininger, P Buchholz, W Kiess, M Siekmeyer, A Bertsche, T Bertsche
Drug incompatibilities can lead to loss of effectiveness of drugs or to increased risk for undesirable effects that can even be life-threatening. Especially children are at high risk. Databases are an important source of information in routine care to avoid incompatibilities. However, they were supposedly developed considering drugs for use in adults. Thus, we analysed to what extent databases are appropriate for the identification of incompatibilities in intravenous (i.v.) drug therapy in paediatric intensive care...
October 1, 2018: Die Pharmazie
T Tachi, A Yoshida, Y Kanematsu, I Sugita, Y Noguchi, T Osawa, M Yasuda, T Mizui, C Goto, H Teramachi
Over-the-counter (OTC) drugs and health foods/supplements are used as means of self-medication with the aim of preventing diseases and maintaining health. No reports have yet addressed the relationship between healthcare systems and self-medication. Here, we carried out a retrospective survey to identify healthcare system factors affecting OTC drug and health food/supplement usage. Patients hospitalized at Gifu Municipal Hospital between October 1, 2014 and March 31, 2015 were given a survey. The items surveyed were age, gender, disease, alcohol intake/smoking status, insurance classification, and medical pharmaceuticals, OTC drugs, and health foods/supplements used immediately before hospitalization...
October 1, 2018: Die Pharmazie
Bo Wu, Xi Chen, Ying Zhou, Pingjun Hu, Dan Wu, Guodong Zheng, Yi Cai
BACKGROUND: Andrographolide (Andro) belongs to the main bioactive ingredients of Andrographis paniculata. Many studies have shown that andro has a variety of pharmacological activities such as anti-inflammatory, anti-bacterial, anti-virus, anti-oxidant, immune regulation and liver protective effects. Moreover andro has been reported to have anticancer activity in multiple types of cancer, including gastric cancer, breast cancer, lung cancer and so on. However, there is no report about the effect of andro on the human NPC cell line C666-1 and the molecular mechanisms of andro-mediated apoptosis in C666-1 cells remain to be clarified...
October 1, 2018: Die Pharmazie
Jinxia Li, Lu Xu, Rui Sang, Yifan Yu, Bingjie Ge, Xuemei Zhang
Astragalus membranaceus Bunge has long been used to improve immune function in traditional Chinese medicine. The total flavonoids of Astragalus (TFA) are the main active components isolated from Astragalus membranaceus Bunge. Our recent study has shown that TFA has in vivo and in vitro immunomodulatory and anti-inflammatory effects; however, its potential mechanisms have not yet been elucidated. The present study aims to confirm the immunomodulatory and anti-inflammatory mechanisms of the action involved. Murine RAW 264...
October 1, 2018: Die Pharmazie
Ting Li, Youran Zhang, Baihui Zhu, Chunfang Wu, Yong Chen
Recent studies have shown that telmisartan (TMS) is effective for the protection against ischemia/brain damage in rat models. However, the specific underlying mechanism is poorly understood. In line with previous results, our data showed that TMS improves CBF and physiological variables, including pH, pCO2, pO2. Through CD31 immunofluorescence staining, reduction of blood vessel density was found in MCAO group, but TMS treatment could enhance the cerebral vascular density in the ischemic area. Meanwhile, TMS treatment could enhance the number of BrdU/lectin double-positive cells...
October 1, 2018: Die Pharmazie
Xianduo Sun, Xiaomin Tang, Quan Yang
An HPLC method for combined quantification of five major constituents (vicenin-1, schaftoside, isoschaftoside, vicenin-3 and isovitexin) of Desmodium styracifolium was developed to evaluate the quality consistency of this medicinal herb. The chromatographic separation was accomplished on an Agilent 5 TC-C18 column (4.6 × 250 mm, 5 μm) with gradient elution using acetonitrile and 0.1 % aqueous formic acid (v/v). The column temperature was 30 °C and the detection wavelength was 272 nm. The chromatographic data were analyzed with a novel systematic quantitative fingerprint method (SQFM)...
October 1, 2018: Die Pharmazie
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