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Die Pharmazie

A Helmstädter
In the early 20th century, the British anthropologist Melville William Hilton-Simpson (1881-1938) did explorations in Africa, mainly the Congo region and the Aurès region in Algeria. He showed considerable interest in local medicinal practices and plants used by the natives, mainly the Algerian Berbers. He left notes, letters and publications about traditional medicine which were screened for relevant information about medicinal plant use. His reports were compared with current knowledge and recent study results...
June 2016: Die Pharmazie
Y Mitani, E Usami, M Kimura, T Nakao, K Okada, T Matsuoka, T Kokuryou, T Yoshimura, M Yamakawa
Neutropenia may develop as an adverse event in patients with multiple myeloma receiving lenalidomide (LEN) plus dexamethasone (DEX) therapy. In the present study, we examined the risk factors associated with grade 3/4 neutropenia during the first cycle of LEN plus DEX therapy. We observed that hemoglobin level (≤ 8.5 g/dl) was a significant risk factor for grade 3/4 neutropenia during the first cycle of therapy (odds ratio: 19.40; 95% confidence interval: 2.68-141.00; p < 0.01). thus, our findings suggest that determining the hemoglobin level could be useful in the risk management for neutropenia in patients receiving LEN plus DEX therapy...
June 2016: Die Pharmazie
Xiaomei Li, Jun Liang, Ying-Xun Liu, Yuming Wang, Xiao-Hui Yang, Bao-Hongluan, Gui-Lling Zhang, Juan Du, Xia-Hong Wu
Resistance to chemotherapy is a main obstacle for effective treatment of gastric cancer, the mechanism of which is still poorly understood. Forkhead box M1 (FoxM1) plays an important role in chemo-resistance of various tumors. This study aimed to explore whether FoxM1 mediated resistance of the gastric cancer cell line SGC7901 to the chemotherapy agent cisplatin (DDP). In the study, we detected FoxM1 and Mcl-1 expression via real time-PCR and western blot and demonstrated that FoxM1 is overexpressed in cisplatin-resistance GC cells and Mcl-1 expression is regulated by FoxM1...
June 2016: Die Pharmazie
Zhi-wei Yang, Fei Wu, Sheng-Li Zhang
Recently, Ganoderma lucidum spores (GLS) have shown anti-epileptic effects. However, there are no reports on the anti-epileptic effects of its chemical constituents ganoderic acids (GAs), and more research is needed to better understand the mechanism of GLS activity. In this work, rat primary hippocampal neurons in an in vitro model were used to assess the intervention effects of GAs on epileptiform discharge hippocampal neurons and expression of both BDNF and TRPC3, with the aid of immunofluorescence, MTT method and flow cytometry...
June 2016: Die Pharmazie
M Chen, B X Qu, X L Chen, H H Hu, H D Jiang, L S Yu, Q Zhou, S Zeng
A transgenic cell line stably expressing the human organic anion transporting polypeptide (OATP1B1) was established. Human Embryonic Kidney 293 (HEK293) cell line stably expressing OATP1B1*1a sequence was amplified through PCR with the extracted total RNA as templates from human liver, then subcloned into the plasmid pMD19-T and verified by sequencing. OATP1B1*1b/OATP1B1*15 mutant sequences were obtained by site-directed mutation PCR with pMD19-T/ OATP1B1*1a as templates. The plasmids pcDNA3.1(+)/OATP1B1*1a, *1b and *15 were constructed and transfected into HEK293 cell line using Lipofectamine 2000 transfection reagent...
June 2016: Die Pharmazie
K Nagai, S Fukuno, H Suzuki, H Konishi
Cytochrome P450 (CYP) in the brain plays an essential role in the local metabolism of various compounds, including clinically used drugs, toxins, and endogenous substances. In the present study, we compared the expression profiles of mRNAs for several CYP subtypes in the brain between male and female rats. The expression of CYP1A2, CYP2B1, and CYP2D2 in females was significantly higher than that in males. On the other hand, the expression level of the other CYP subtypes examined in the male brain was similar to that in the female brain...
June 2016: Die Pharmazie
X Li, R H Müller, C M Keck, N A Bou-Chacra
Dexamethasone acetate (DEX) and polymyxin B sulfate (polymyxin B) were formulated as a cationic nanoemulsion for the treatment of ophthalmic infections. As novel concept, the positive charge to achieve mucoadhesion was not generated by toxicologically and regulatorily problematic cationic lipids or polymers, but by using a positively charged drug in combination with positively charged preservatives. The preservative also acts as co-surfactant to stabilize the emulsion. Nanoemulsions with the lipid phase Eutanol G-Lipoid S 100 (70%:30%) containing 0...
June 2016: Die Pharmazie
Bin Zhang, Aiying Xue, Chen Zhang, Jinlong Yu, Wen Chen, Deqing Sun
Paclitaxel (PTX), a BCS class IV drug that is characterized by its poor solubility and is a substrate for P-glycoprotein, is one of the most widely used antineoplastic agents. However, oral administration of PTX for chemotherapy is highly challenging. The aim of this study was to develop bile-salt liposomes (BS-Lips) to enhance the absorption of PTX and thus improve its therapeutic outcome. The BS-Lips were prepared by the thin-film hydration method and characterized in terms of particle size and morphology...
June 2016: Die Pharmazie
D Kilian, H J R Lemmer, M Gerber, J L du Preez, J du Plessis
Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by these models may not be sufficiently accurate. In this study, exploratory data analysis of the probabilistic dependencies between molecular weight, log P and log Kp was performed on a dataset constructed from the combination of several popular datasets. The results suggest that, in general, molecular weight and log P are poorly correlated to log Kp...
June 2016: Die Pharmazie
Yadan Wang, Yi He, Zhong Dai, Shuangcheng Ma
A rapid resolution liquid chromatography-tandem mass spectrometry (RRLC-MS/MS) method was developed and validated for the determination of five major saponins (macranthoidin B, macranthoidin A, dipsacoside B, akebiasaponin D, and dipsacoside A) in the flower bud, stem, and leaf parts of Lonicera macranthoides. Chromatographic separation was performed on a ZORBAX SB-C18 column (2.1 x 50 mm, 1.8 μm). Acetonitrile and 0.1% aqueous formic acid were adopted as mobile phase. Detection was carried out on a triple quadrupole mass spectrometer in the negative ion mode using an electrospray source...
June 2016: Die Pharmazie
C Lang, C Staiger
The antimicrobial agent tyrothricin is a representative of the group of antimicrobial peptides (AMP). It is produced by Bacillus brevis and consists of tyrocidines and gramicidins. The compound mixture shows activity against bacteria, fungi and some viruses. A very interesting feature of AMPs is the fact, that even in vitro it is almost impossible to induce resistances. Therefore, this class of molecules is discussed as one group that could serve as next generation antibiotics and overcome the increasing problem of bacterial resistances...
June 2016: Die Pharmazie
G A Petroianu
A "Privileg" for a pharmacy in Gersfeld (Rhoen) was issued October 26, 1788 by the ruler of Gersfeld, the Reichsfreiherr Amand von Ebersberg (1747- 1803), to Peter Franz Wilhelm Feuchter (1766-1835). Feuchter was not only a dedicated pharmacist but also scholarly active both by publishing and by serving on various journal editorial boards. Vitus Jacobus Metz (1792-1866) was accepted 1808 as an apprentice in the pharmacy and later enjoyed private lessons from Feuchter (until around 1813, when he gave up the study of pharmacy to pursue medical studies in Würzburg)...
May 2016: Die Pharmazie
Jingtian Mei, Yang Yu, Jianxia Ma, Xiaofeng Yu
Here we aimed to evaluate the effectiveness of esomeprazole treatment strategies comparing with other proton pump inhibitors (PPI) in clinical practice for six months in the management of patients with symptomatic gastroesophageal reflux disease (GERD). An extensive search of the literature focusing on PPI therapeutic evaluation was performed up to December 2014. Risk ratio (RR) with its corresponding 95% confidence intervals (CIs) in each study was chosen as the effect size. Cochrane's Q statistic and I2 test were both conducted to evaluate heterogeneity across individual studies...
May 2016: Die Pharmazie
Zhaohui Zhong, Yuandong Cao, Shen Yang, Shukun Zhang
The ribonucleotide reductase M2 subunit (RRM2) plays an active role in tumor progression and is frequently overexpressed in cancer. It plays a significant role in the regulation of cell invasiveness, cell migration and tumor metastasis. Elevated RRM2 expression has been reported to be associated with poor prognosis of gastric cancer. However, the molecular mechanisms of RRM2 in gastric cancer cells remain elusive. In our study, we found that RRM2 highly expressed in gastric cancer cells BGC823. RRM2 stimulation dose-dependently enhanced the invasion and migration of BGC823 cells...
May 2016: Die Pharmazie
Yun-hee Lee, Jaesuk Yun, Jae-Chul Jung, Seikwan Oh, Young-Suk Jung
A number of some chalcone derivatives possess promising biological properties including anti-inflammation, anti-oxidant, and anti-tumor activity. Although it has been shown that some derivatives of chalcone induce apoptosis in different kinds of cancer cells, the involved mechanism of action is not well defined. The purpose of this study is to investigate the primary target of a benzylideneacetophenone derivative (JC3), which is a synthetic compound derived from the chalcone family, in human cancer, using prostate cancer cells as a working model...
May 2016: Die Pharmazie
Chaoran Zhu, Xuejia Zhai, Fen Chen, Nanxi Wang, Xinlin Zhang, Yongning Lu
Capsaicin (CAP, trans-8-methyl-N-vanillyl-6-nonenamide) is a major pungent substance in hot pepper. However, little is known about the interactions between CAP and clinically used drugs. This study investigated the effect of acute and chronic ingestion of CAP on pharmacokinetics of simvastatin (SV) and the mechanism of this CAP--drug intercation. CAP was orally administered at doses of 3 and 8 mg x kg(-1) for seven consecutive days once daily and on the 1st day and the 7th day, SV (8 mg x kg(-1)) was injected intravenously...
May 2016: Die Pharmazie
P Bukovec, P Benkic, M Smrkolj, F Vrecer
Simvastatin crystals, having same crystal structure but different types of habits and hence different intrinsic dissolution rate, were prepared by recrystallization from solvents selected according to their polarity index. Scanning electron microscopy, laser diffraction, image analysis, X-ray powder diffractometry, Fourier transform infrared spectroscopy and differential scanning calorimetry were used to investigate the physicochemical characteristics of the prepared crystals. The isolated crystals exhibited different crystal habits but possessed the same internal crystal structure...
May 2016: Die Pharmazie
J Alyoussef Alkrad, A Shukla, Y Mrestani, R H H Neubert
In this study the effect of dimethylsulfoxide (DMSO) radii on the droplets and on the required non-ionic surfactant volume for preparing water-in-oil microemulsions (MEs) was investigated. Five series of MEs were prepared either with the aid of isopropylpalmitate or medium chain triglycerides (MCTG) as continuous phases. The MEs were stabilized via either Tween80 or Span20 or a mixture of both. A mixture of water:DMSO (W:DMSO) with different ratios formed the colloidal phase of the first four MEs series. Only DMSO was used as colloidal phase of the fifth series...
May 2016: Die Pharmazie
W P Wang, J Hul, H Sui, Y S Zhao, J Feng, C Liu
Glabridin, a polyphenolic flavonoid from licorice, has inspired great interest for its antioxidant, anti-inflammatory and skin-lightening activities. However, low water solubility and poor stability of glabridin impedes its topical application in cosmetic products and therapies of dermal diseases. The purpose of this study was to develop a nanosuspension formulation of glabridin to improve its skin permeation. Glabridin nanosuspensions were prepared using anti-solvent precipitation-homogenization method, and Box-Behnken design was adopted to investigate the effects of crucial formulation variables on particle size and to optimize the nanosuspension formulation...
May 2016: Die Pharmazie
S Babaei, S Ghanbarzadeh, Z M Adib, M Kouhsoltani, S Davaran, H Hamishehkar
Lipid based nanoparticles have become a major research object in topical drug delivery to enable drugs to pass the stratum corneum and reach the desired skin layer. The present investigation deals with the encapsulation of lidoacine into nanostructured lipid carriers (NLCs) and nanoethosomes for improving its dermal delivery and consequently local anesthetic efficacy. Concurrently these two topical delivery systems were compared. Lidocaine-loaded NLCs and nanoethosomes were characterized by various techniques and used for an in vitro skin penetration study using excised rat skin and Franz diffusion cells...
May 2016: Die Pharmazie
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