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Annals of Diagnostic Pathology

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https://www.readbyqxmd.com/read/29146062/three-cases-of-adrenocortical-tumors-mistaken-for-hepatocellular-carcinomas-diagnostic-pitfalls-and-differential-diagnosis
#1
Won Young Park, Hyung Il Seo, Kyung Un Choi, Ahrong Kim, Young Keum Kim, So Jeong Lee, Chang Hun Lee, Gi Yeong Huh, Do Youn Park
Adrenocortical adenomas and carcinomas in other parenchyma are extremely rare, with few cases reported and because of the rarity of these tumors, they occasionally cause problems during diagnosis. Adrenal cortical neoplasms in liver parenchyma can be present in 3 forms, including direct invasion or adhesion to liver parenchyma, tumors arising in adrenohepatic fusion tissue or in ectopic adrenal gland tissue. We report 3 cases of adrenal cortical tumors that were misdiagnosed as hepatocellular carcinoma in the preoperative state...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146061/sarcoid-like-granulomas-in-renal-cell-carcinoma-the-houston-methodist-hospital-experience
#2
Komal Arora, Mukul K Divatia, Luan Truong, Steven S Shen, Alberto G Ayala, Jae Y Ro
Sarcoid-like (SL) granulomas have been previously described in association with malignant tumors. These granulomas appear to be tumor-related but are not indicative of systemic sarcoidosis, and hence are referred to as SL reactions. These SL reactions can be seen within the primary tumor, its vicinity, or in uninvolved sites such as the spleen, bone marrow, skin, and/or regional lymph nodes draining the tumor. It is a widely held view that SL granulomas are caused by soluble antigenic factors, shed by tumor cells or released due to tumor necrosis...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146060/clinicopathologic-correlation-of-programmed-death-ligand-1-expression-in-non-small-cell-lung-carcinomas-a-report-from-india
#3
Archana George Vallonthaiel, Prabhat Singh Malik, Varsha Singh, Vinay Kumar, Sunil Kumar, Mehar Chand Sharma, Sandeep Mathur, Sudheer Arava, Randeep Guleria, Deepali Jain
INTRODUCTION: Increased expression of Programmed death ligand-1 (PD-L1) on cancer cells and immune cells predict response to PD-1/PDL1 inhibitors. Data regarding frequency and pattern of PD-L1 expression in NSCLC from India is not available. OBJECTIVES: To analyse PD-L1 expression on tumour cells (TC) and immune cells (IC) and to correlate PD-L1 expression with baseline clinico-pathological characteristics, oncogenic drivers and outcome data. MATERIALS AND METHODS: PD-L1 expression on tumour cells and immune cells was analysed...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146059/oral-lymphomatoid-papulosis-type-c-a-diagnostic-pitfall-often-confused-with-t-cell-lymphoma
#4
Ziv Schwartz, Morton Coleman, Jennifer P Toyohara, Paul D Freedman, Cynthia M Magro
Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+ LPD)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146058/methylation-associated-silencing-of-sfrp1-gene-in-high-grade-serous-ovarian-carcinomas
#5
Vedran Kardum, Valentina Karin, Mislav Glibo, Anita Skrtic, Tamara Nikuseva Martic, Nermina Ibisevic, Faruk Skenderi, Semir Vranic, Ljiljana Serman
Wnt is a highly conserved signaling pathway responsible for tissue regeneration, maintenance and differentiation of stem cells in adults. Its aberrant activation through reduced expression of Wnt signaling pathway inhibitors, such as proteins from the SFRP family, is commonly seen in many tumors. In the present study we explored SFRP1 protein expression using immunohistochemistry in 11 low-grade serous ovarian carcinomas (LGSC), 42 high-grade serous ovarian carcinomas (HGSC), and 5 normal ovarian tissues (controls)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146057/role-of-angiogenesis-in-colorectal-carcinomas-using-vegf-and-bcl2-an-ihc-study
#6
Anjaneyulu Vasala, Haripreetha Nair, T Subramanyeshwar Rao, S Sudha Murthy, Ravindranath Tagore, Faiq Ahmed
No abstract text is available yet for this article.
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146056/comparison-of-her2-status-determination-methods-in-her2-2-patients-manual-fluorescent-in-situ-hybridization-fish-vs-dual-silver-enhanced-in-situ-hybridization-sish
#7
Burcin Pehlivanoglu, Gurdeniz Serin, Levent Yeniay, Osman Zekioglu, Erhan Gokmen, Necmettin Ozdemir
HER2 amplification has been demonstrated in 15-25% of invasive breast carcinomas and can be assessed using immunohistochemical and in situ hybridization methods. Here, we compared the accuracy of dual SISH to manual FISH in HER2 (2+) breast carcinoma and evaluated the feasibility of dual SISH method in routine practice. Sixty HER2 (2+) consecutive tumor samples diagnosed between January 2009 and February 2013 were selected. Demographic, histological and immunohistochemical features and FISH results were recruited from patient records and compared to dual SISH results...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146055/imp3-contributes-to-poor-prognosis-of-patients-with-metaplastic-breast-carcinoma-a-clinicopathological-study
#8
Ryuji Ohashi, Maoka Sangen, Shigeki Namimatsu, Hiroyuki Takei, Zenya Naito
Metaplastic breast carcinoma (MBC) is a rare type of tumor with heterogenous histological patterns. We investigated the immunohistochemical expression of IMP3, an oncofetal protein, in 31 MBC patients in association with histological subtypes and clinical outcomes. The cohort consisted of spindle cell carcinoma (SPC) (n=11), squamous cell carcinoma (SCC) (n=14), matrix-producing carcinoma (MPC) (n=4), carcinoma with osteocartilaginous elements (COC) (n=1), and low grade adenosquamous cell carcinoma (ASC) (n=1)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146054/lymphocytic-thrombophilic-arteritis-a-distinct-inflammatory-type-i-interferon-and-c5b-9-mediated-subcutaneous-endovasculitis
#9
Cynthia M Magro, Jad Saab
BACKGROUND: Lymphocytic thrombophilic arteritis is a recently recognized subcuticular larger vessel vasculitis characterized by striking vascular luminal thrombosis. METHODS: The clinical features, histopathology and phenotypic profile of ten patients with lymphocytic thrombophilic arteritis were explored in an attempt to better define the entity from a clinical and pathophysiologic perspective. RESULTS: The patients were all female (mean age of 43) presenting with generally asymptomatic lower and upper extremity hyperpigmented macules...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146053/usefulness-of-a-direct-immunofluorescence-in-the-diagnosis-of-plaque-type-oral-lichen-planus
#10
Patricia Alejandra Masquijo-Bisio, Mariana Silvia Gandolfo, Alicia Keszler, Maria Elina Itoiz, María Luisa Paparella
No abstract text is available yet for this article.
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146052/phenotypic-alterations-in-breast-cancer-associated-with-neoadjuvant-chemotherapy-a-comparison-with-baseline-rates-of-change
#11
Nosaibah Hariri, Andres A Roma, Farnaz Hasteh, Vighnesh Walavalkar, Oluwole Fadare
Several studies have documented phenotypic alterations in breast cancer associated with neoadjuvant chemotherapy [NACT], but many of these studies are limited by the fact that they did not account for the baseline rate of expected phenotypic change between biopsies and resections in the absence of NACT. Herein, we assess whether the NACT-associated rate of phenotypic change is significantly different than would be expected in a control population of patients that did not receive NACT. From a pathologic database, we documented the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2/neu) phenotypes of consecutive invasive breast carcinomas (n=826), as well as the subset in which at least one of these tests was assessed in both the biopsy and resection (n=340)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146051/beta-catenin-and-p53-expression-in-topographic-compartments-of-colorectal-cancer-and-its-prognostic-value-following-surgery
#12
Juan Daniel Prieto, Martina Álvarez, María Isabel Hierro, Isabel García, Luis Vicioso
Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and the fourth cause of cancer-related death. From Vogelstein's initial model, new molecular knowledge has been incorporated which includes an elevated number of genetic mutations, many of them located in the Wnt pathway, which affect its principle effector: β-catenin. Additionally, it is necessary to keep the heterogeneity of CRCs in mind, both in terms of morphology and biology. The aim of this work is to study the interaction between the Wnt molecular pathway, by means of immunoexpression of β-catenin, in CRC and other molecular mechanisms, such as the p53 pathway, in order to determine the pattern - if one exists - of different immunohistochemical expression of β-catenin and p53 in the superficial and deep tumor components, and lastly, to determine the impact of these markers on prognosis...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965630/expression-of-dog1-in-low-grade-fibromyxoid-sarcoma-a-study-of-19-cases-and-review-of-the-literature
#13
Ana Vallejo-Benítez, Enrique Rodríguez-Zarco, Sara Pabón Carrasco, Sofia Pereira-Gallardo, Javier Brugal Molina, Antonio García-Escudero, Antonio Robles Frías, David Marcilla, Ricardo González-Cámpora
DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the abdominal cavity. This paper reports on immnohistochemical expression of DOG1 in 19 LGFMSs using two different monoclonal antibodies: K9 (Leica, Novocastra Laboratories, Newcastle upon Tyne, UK) and SP31 (Thermo Scientific, Freemont, USA)...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965629/cd30-t-cell-enriched-primary-cutaneous-cd4-small-medium-sized-pleomorphic-t-cell-lymphoma-a-distinct-variant-of-indolent-cd4-t-cell-lymphoproliferative-disease
#14
REVIEW
Cynthia M Magro, Luke C Olson, Clifton G Fulmer
Primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoma (SMPTCL) is unique among the peripheral T-cell lymphomas because of its indolent nature, typically presenting as a solitary nodule or plaque in the head and neck area of middle-aged and older adults. Recent studies have suggested a follicular helper cell origin for these lesions. MATERIALS AND METHODS: A retrospective review was conducted on all cases of SMPTCL diagnosed between 2008 and 2017. The goal of our study was to better categorize the clinical, pathologic and molecular features of cases of SMPTCL showing a significant degree of CD30 neoplastic large cell infiltration...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965628/cyclin-d1-is-significantly-associated-with-stage-of-tumor-and-predicts-poor-survival-in-endometrial-carcinoma-patients
#15
Mohamad Nidal Khabaz, Amer Shafie Abdelrahman, Nadeem Shafique Butt, Basim Al-Maghrabi, Jaudah Al-Maghrabi
Cyclin D1 overexpression has been described to have oncogenic role and association with diagnosis, prognosis and survival in various tumors. This study will describe the immunohistochemical phenotype of cyclin D1, and investigate the correlation between these patterns of expression and clinicopathological parameters of endometrial carcinomas, to conclude the clinical relevance of cyclin D1 expression in the evolution of endometrial neoplasms. This study employed 101 endometrial tissue samples which include 71 endometrial carcinomas and thirty normal and benign endometrium cases...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965627/dedifferentiated-chondrosarcoma-of-the-larynx-radiological-gross-microscopic-and-clinical-features
#16
Kelly R Magliocca, Mark A Edgar, Amanda Corey, Craig R Villari
Laryngeal chondrosarcoma is an uncommon malignancy with a predilection for the cricoid cartilage of adult male patients. Although rare, identification of aggressive chondrosarcoma variants, such as dedifferentiated chondrosarcoma (DDCS) may influence preoperative patient counseling, definitive surgical management, potential implementation of post-operative adjuvant therapy and prognosis. Herein we describe clinical and imaging features of laryngeal DDCS, the unique perspective of fresh and formalin fixed macroscopic examination, a spectrum of histopathologic findings, and detail the full course of the patient's disease...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965626/establishing-fascin-over-expression-as-a-strategic-regulator-of-neoplastic-aggression-and-lymph-node-metastasis-in-oral-squamous-cell-carcinoma-tumor-microenvironment
#17
Samapika Routray, Supriya Kheur, Hemlata M Chougule, Neeta Mohanty, Rupesh Dash
INTRODUCTION: Oral squamous cell carcinoma (OSCC) has an aggressive behaviour with high incidence of nodal metastasis, even in the early stages, leading to poor prognosis. For progression and metastasis of cancers, the dominant element considered is cell motility. Fascin, an actin-binding protein has emerged as a protein of general importance for a diverse set of cell protrusions with functions in cell adhesion, cell interactions, and cell migration. The role of Fascin in various carcinomas, including aggressive behaviour in OSCC has been documented, but its role as a key regulator in lymph nodes metastasis is yet to be validated...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965625/immunohistochemical-expression-of-p53-and-c-myc-at-the-invasive-front-of-oral-squamous-cell-carcinoma-and-its-relation-with-clinicopathologic-characteristics
#18
Pragati Rai, Swetha Acharya, Amsavardani Tayaar, Jyoti Kale, Kaveri Hallikeri
No abstract text is available yet for this article.
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965624/utility-of-different-immunostains-for-diagnosis-of-metastatic-breast-carcinomas-in-both-surgical-and-cytological-specimens
#19
Yanjun Hou, Rulong Shen, Shweta Chaudhary, Dena Tonkovich, Zaibo Li
OBJECTIVE: A panel of immunostains is usually performed to confirm a metastatic carcinoma origin. GATA3 is a transcription factor and has been proven to be a useful marker for breast carcinoma. Other immunostains including mammaglobin (MGB), gross cystic disease fluid protein 15 (GCDFP-15), estrogen receptor (ER) and progesterone receptor (PR) are also used in diagnosing metastatic breast cancer. In this study, we aimed to compare the performance of these immunostains in the work up of metastatic breast carcinoma in both surgical and cytological specimens...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28965623/histological-immunohistochemical-features-and-pathogenesis-of-pseudoangiosarcomatous-urothelial-carcinoma
#20
Pelin Yıldız, Kemal Behzatoğlu, Ezgi Hacıhasanoğlu, Oğuzhan Okcu, Haydar Durak, Uğur Yücetaş
No abstract text is available yet for this article.
October 2017: Annals of Diagnostic Pathology
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