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Annals of Diagnostic Pathology

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https://www.readbyqxmd.com/read/27810344/re-immunoexpression-of-p53-in-cutaneous-and-subcutaneous-leiomyosarcomas
#1
LETTER
David Creytens
No abstract text is available yet for this article.
October 27, 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806883/answer-to-immunoexpression-of-p53-in-cutaneous-and-subcutaneous-leiomyosarcomas
#2
LETTER
Angel Fernandez-Flores, Carlos Monteagudo
No abstract text is available yet for this article.
October 27, 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806853/cutaneous-myeloid-dendritic-cell-dyscrasia-a-cutaneous-clonal-monocytosis-associated-with-chronic-myeloproliferative-disorders-and-peripheral-blood-monocytosis
#3
Cynthia M Magro, Shabnam Momtahen, Shalini Verma, Ronnie M Abraham, Constantin Friedman, Gerard J Nuovo, Wayne Tam
Monocytes are critical components of the innate immune system and they can differentiate into dendritic cells (DCs). Cutaneous neoplasms of dendritic cell origin are uncommon and mostly represented by histiocytic lesions derived primarily from Langerhans cells. The myeloid DC (mDC) while recognized in the immunology literature does not have a well-defined neoplastic cutaneous counterpart. Eleven patients with a diagnosis of cutaneous mDC dyscrasia were evaluated. Routine hematoxylin and eosin stain were performed followed by selective phenotypic studies...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806852/ameloblastoma-vs-basal-cell-carcinoma-an-immunohistochemical-comparison
#4
Salam N Jawad, Bashar H Abdullah
Despite behavioral mimicry of ameloblastoma (AB) and basal cell carcinoma (BCC), they are classified at 2 extremes within pertinent WHO classifications with respect to benign and malignant designation. This study aims to appraise the current allocation of AB in the classification through an immunohistochemical comparison of some aspects of behavior with BCC. Sections from retrospectively retrieved formalin-fixed, paraffin-embedded tissue blocks of AB (n = 37) and BCC (n = 34) were comparatively examined for the immunohistochemical expression for Ki-67, Bcl-2, MMP-2, MMP-9, CD31, and D2-40 monoclonal antibodies...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806851/correlation-of-microvessel-parameters-in-invasive-ductal-carcinoma-of-the-breast-and-fibroadenomas-a-morphometric-study
#5
Dibyajyoti Boruah, Jasvinder K Bhatia, Abhishek Rai, V Srinivas, V S Nijhawan
Modifications of microvascular configuration are essential features encountered during the progression of breast tumors. Our objectives were to correlate morphometrically evaluated microvessel parameters (microvessel density [MVD], microvessel caliber [VC], microvessel cross-sectional area [VCSA], percentage of total VCSA [%TVCSA], and total microvessel boundary density [TVBD]) with histologic grades of invasive ductal carcinoma (IDC) of the breast and benign breast lesions. Sixty cases of IDC presented with modified radical mastectomy, and 20 benign breast fibroadenomas were evaluated for various microvessel parameters, using CD34-immunostained histologic sections by computerized image morphometry...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806850/aggressive-b-cell-lymphomas-frequency-immunophenotype-and-genetics-in-a-reference-laboratory-population
#6
Yalda B Naeini, Annie Wu, Dennis P O'Malley
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma worldwide. The current World Health Organization classification includes several subtypes based on a combination of clinical, immunohistochemical, and genetic differences. Other aggressive variants of B-cell lymphomas, including Burkitt lymphoma and double-hit lymphomas are part of the differential diagnosis and often have overlapping features with DLBCL. In this study, we evaluated 760 of cases of DLBCL and other aggressive B-cell lymphomas using a relatively uniform immunohistochemical panel and genetic methods...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806849/dermatofibrosarcoma-protuberans-pathology-genetics-and-potential-therapeutic-strategies
#7
Khin Thway, Jonathan Noujaim, Robin L Jones, Cyril Fisher
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a malignant fibroblastic tumor most frequently arising in middle-aged adults. It is typically a low-grade sarcoma that grows slowly but has a high rate of local recurrence with low metastatic potential. Dermatofibrosarcoma protuberans is characterized by a specific translocation t(17;22)(q22;q13) leading to the formation of COL1A1-PDGFB fusion transcripts. Histologically, DFSP has characteristic morphology, of storiform islands of bland spindle cells, and immunohistochemically, it shows diffuse expression of CD34...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806848/a-comparison-of-cancer-stem-cell-markers-and-nonclassical-major-histocompatibility-complex-antigens-in-colorectal-tumor-and-noncancerous-tissues
#8
Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
Colorectal carcinoma (CRC) is one of the most fatal types of cancer in both women and men, and, unfortunately, patients are often diagnosed at an advanced stage. Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance. Therefore, different treatment alternatives are needed to facilitate the elimination of CSCs. One such approach is immunotherapy; however, tumor cells can evade immune cells by alteration of the expression patterns of human leukocyte antigens (HLA)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806847/false-positive-results-in-diagnostic-immunohistochemistry-are-related-to-horseradish-peroxidase-conjugates-in-commercially-available-assays
#9
Gerard Nuovo
False-positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of 10 different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806846/gastric-mixed-adenoneuroendocrine-carcinoma-correlation-of-histologic-characteristics-with-prognosis
#10
Ling Nie, Mingna Li, Xiaofeng He, Anning Feng, Hongyan Wu, Xiangshan Fan
Gastric mixed adenoneuroendocrine carcinomas (MANECs) are rare, with both the exocrine and neuroendocrine components exceeding 30% volume. Several classifications for MANECs have been proposed, yet they have not been clinically evaluated. The aim of this study was to evaluate the correlation between tumor grade, histologic characteristics, and prognosis of gastric MANECs. We collected eligible 14 cases in our series and 31 cases in the literature and compared the prognostic difference among gastric MANECs with different histologic characteristics...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806845/lymphoepithelioma-like-carcinoma-of-breast-evaluation-for-epstein-barr-virus-encoded-rna-human-papillomavirus-and-markers-of-basal-cell-differentiation
#11
Tanuja Shet, Trupti Pai, Omshree Shetty, Sangeeta Desai
This is a largest series of 5 cases of lymphoepithelioma-like carcinoma (LEC) of the breast attempting to look at the expression of basal cytokeratins (CKs), human papillomavirus, and Epstein-Barr virus-encoded RNAs in these tumors. Five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. Histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. All tumors were negative for estrogen and progesterone receptors and HER2 (triple negative)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806844/myxoid-liposarcoma-of-the-foot-a-study-of-8-cases
#12
Elise M Bekers, Wangzhao Song, Albert J H Suurmeijer, Johannes J Bonenkamp, Ingrid C van der Geest, Petra M Braam, Marieke J M Ploegmakers, Ingrid M E Desar, Bastiaan B J Tops, Joost M van Gorp, David H Creytens, Thomas Mentzel, Uta Flucke
INTRODUCTION: Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. We present a series of 8 cases occurring in the foot/ankle. RESULTS: Two female and 6 male patients, aged between 32 and 77 years (mean, 54.3 years), were identified. Tumor size ranged from 1.1 to 10 cm (mean, 6.8 cm). Two lesions eroded bone...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806843/an-isolated-inflammatory-myofibroblastic-tumor-of-adrenal-gland
#13
Ghadah Al Sannaa, Jana L Wimmer, Alberto G Ayala, Jae Y Ro
Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion that shows a wide range of anatomic distribution. The adrenal gland, however, is a distinctly rare site of occurrence. To date, only a few cases of IMT arising in the adrenal gland have been reported in the English literature. Here, we report another case of isolated adrenal IMT. A 34-year-old man presented to the emergency department with a complaint of a sudden severe right-sided back pain. Subsequent computed tomographic scan imaging studies demonstrated a large right adrenal mass associated with a hematoma...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806842/mesothelial-cell-deposits-in-lymph-nodes-a-diagnostic-pitfall
#14
LETTER
Archana Pandita, Vladimir Osipov
No abstract text is available yet for this article.
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806841/diagnostic-pitfalls-of-infarcted-warthin-tumor-in-frozen-section-evaluation
#15
Yaohong Tan, Oleksandr N Kryvenko, Darcy A Kerr, Jennifer R Chapman, Christina Kovacs, David J Arnold, Andrew E Rosenberg, Carmen R Gomez-Fernandez
Warthin tumor (WT) is the second most common benign salivary gland neoplasm and has characteristic cytologic and histologic findings. Fine-needle aspiration is a common and useful preoperative diagnostic technique, which sometimes leads to ischemic injury resulting in the infarction of these lesions. Infarcted WT may demonstrate variable gross and histologic alterations that may render the diagnosis challenging, particularly during intraoperative frozen section evaluation. In this study, we collected 11 resection specimens from 9 patients with infarcted WT...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806840/lobular-neoplasia-diagnosed-on-breast-core-biopsy-frequency-of-carcinoma-on-excision-and-implications-for-management
#16
Benjamin C Calhoun, Angela M B Collie, Abberly A Lott-Limbach, Esther N Udoji, Leah R Sieck, Christine N Booth, Erinn Downs-Kelly
The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to mandatory surgical excision in all cases. We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision. The goal of the study was to identify potential predictors of upgrade to a more significant lesion...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806839/proliferation-centers-in-bone-marrows-involved-by-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-a-clinicopathologic-analysis
#17
Jason C Chang, Alexandra M Harrington, Horatiu Olteanu, Peter VanTuinen, Steven H Kroft
OBJECTIVES: Proliferation centers (PCs) are a characteristic finding in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) lymph nodes, and their presence and extent in this site are not currently felt to be related to clinical course. In contrast, detailed clinicopathologic analyses of bone marrow (BM) PCs have not been previously reported. METHODS: The PCs in 88 CLL/SLL BMs from 45 patients (pts) were graded (0-4) and were correlated with other morphologic, immunophenotypic, cytogenetic, and laboratory features...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27806838/intralymphatic-nevus-cells-in-benign-nevi
#18
Cem Leblebici, Canan Kelten, Mehmet Salih Gurel, Ezgi Hacıhasasanoglu
The histogenesis of nevus cell aggregates in lymph nodes lesion is controversial, and various hypotheses have been used to explain their origin. One of them is the transport of cells from cutaneous nevi or lesions to lymph nodes, called mechanical transport theory. We investigated in our cases of benign nevi to obtain evidence to substantiate this theory. A total of 369 benign cutaneous nevi were prospectively evaluated in excisional biopsy samples. Immunohistochemical stainings for CD31 and podoplanin (D2-40) were performed in the cases with intralymphatic nevus cell aggregate (ILNA), suspected for ILNA, and/or intralymphatic nevus cell protrusion...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27649957/differential-expression-of-epithelial-cell-adhesion-molecule-in-salivary-gland-neoplasms
#19
Ekarat Phattarataratip, Marisa Masorn, Werapong Jarupoonphol, Sirinpaporn Supatthanayut, Pichanee Saeoweiang
Epithelial cell adhesion molecule (EpCAM) is the epithelial-specific molecule expressed on various epithelial cell types. The function of EpCAM involves cellular adhesion, proliferation, and signaling in both normal tissues and cancers. The purposes of this study were to investigate the EpCAM expression in salivary gland neoplasms and examine its relationship with pathologic characteristics. Forty-two cases of salivary gland neoplasms, including 20 mucoepidermoid carcinomas (MECs), 11 adenoid cystic carcinomas (ACCs), 9 pleomorphic adenomas (PAs), and 2 polymorphous low-grade adenocarcinomas (PLGAs) were enrolled...
October 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27649956/inflammation-and-focal-atrophy-in-prostate-needle-biopsy-cores-and-association-to-prostatic-adenocarcinoma
#20
Ines Benedetti, Alfonso Bettin, Niradiz Reyes
The possible origin of proliferative inflammatory atrophy in the regenerative proliferation of prostate epithelial cells in response to injury caused by inflammation, and their relation to prostate adenocarcinoma have not been defined. Inflammation and focal atrophy are common pathological findings in prostate biopsies, currently not routinely included in surgical pathology reports. The objective of the study was to determine the correlation between inflammation and focal atrophy with prostate adenocarcinoma...
October 2016: Annals of Diagnostic Pathology
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