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Annals of Diagnostic Pathology

Yu Ting Felicia Wee, Syed Muhammad Fahmy Alkaff, Jeffrey Chun Tatt Lim, Josh Jie Hua Loh, Maryam Hazly Hilmy, Clara Ong, Wen Long Nei, Amit Jain, Alvin Lim, Angela Takano, Rafay Azhar, Wei Keat Wan, Evan Newell, Joe Yeong, Tony Kiat Hon Lim
BACKGROUND/AIM: Epstein-Barr virus (EBV) is an oncovirus that is commonly associated with the development of lymphomas and epithelial carcinomas. In the era of immunotherapy, histological evaluation of EBV-related cancers is currently a multi-sample, multi-technique process requiring separate time-consuming detection of EBV-encoded small RNAs by in situ hybridisation (ISH), and parallel labelling of sections for cancer-associated protein markers. METHODS: Using EBV-associated tumours as proof-of-concept for feasibility, here we developed an approach that allows simultaneous detection of EBV RNAs and multiple protein markers such as PD-L1, EBV-LMP, CD8, CD4, CD20, CD30 and CD15on a single tissue section based on our recently reported automated staining protocol...
September 11, 2018: Annals of Diagnostic Pathology
Dustin E Bosch, Matthew M Yeh, Rodney A Schmidt, Paul E Swanson, Camtu D Truong
Gallbladder carcinoma (GC) is an uncommon malignancy with an overall 5-year survival of <5%. Due to overlap of clinical presentation with the more common cholecystitis, an estimated 50-65% of all GCs are found incidentally. Epithelial dysplasia is identified in ~50% of specimens with invasive carcinoma. Recent expert panel guidelines have recommended histologic examination of the entire gallbladder in cases where initial sampling reveals dysplasia. 89 cases of GC, 34 high grade dysplasia (HGD), and 60 low grade dysplasia (LGD) were identified in cholecystectomy specimens assessed at our institution over the last 15 years...
September 5, 2018: Annals of Diagnostic Pathology
Richard A Prayson, Elizabeth E O'Toole
No abstract text is available yet for this article.
September 4, 2018: Annals of Diagnostic Pathology
Jingjing Hu, Raji D Khalifa, Andres A Roma, Oluwole Fadare
The problems associated with the pathologic distinction of primary ovarian mucinous tumors from their metastatic counterparts are well-recognized. Herein, we systematically evaluate a variety of gross parameters to determine the combination of features that most optimally separate primary from secondary mucinous ovarian tumors, and to address the tumor types that are most frequently associated with exceptions. 129 consecutive mucinous tumors involving the ovary formed the study set, including 61 primary mucinous tumors (16 carcinomas, 45 borderline tumors), and 68 metastatic carcinomas (21 colon; 28 appendix; 5 breast; 3 lung; 3 pancreas; 3 cervix; 1 bladder; 4 stomach)...
August 8, 2018: Annals of Diagnostic Pathology
João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, Fabrício Passador-Santos, Andresa Borges Soares, Ney Soares de Araújo, Vera Cavalcanti de Araújo
Considered as an aggressive counterpart of central ossifying fibroma (OF), juvenile ossifying fibroma (JOF) is a benign fibro-osseous neoplasm characterized by an unpredictable destructive behavior, elevated morbidity, mutilating treatment and high potential for local recurrences. The aim of this study is to compare the analysis for cell proliferation and vascular markers between JOF and OF. Cell proliferation index was measured by Ki-67 and Mcm-2 expression and microvessel density (MVD) was obtained by the immunoexpression of CD34/CD105...
August 4, 2018: Annals of Diagnostic Pathology
Bharat Rekhi, Chhavi Gupta, Girish Chinnaswamy, Sajid Qureshi, Tushar Vora, Nehal Khanna, Siddhartha Laskar
The present study was aimed at evaluating clinicopathologic and immunohistochemical (IHC) features of 300 rhabdomyosarcomas (RMSs), including differential IHC expression and prognostic value of myogenin and MyoD1 across various subtypes of RMSs. IHC expression of myogenin and MyoD1 was graded on the basis of percentage of tumor cells displaying positive intranuclear immunostaining i.e. grade 1 (1-25%); grade 2 (26-50%); grade 3 (51-76%) and grade 4 (76-100%).Clinical follow-up was available in 238 (79.3%) patients...
August 3, 2018: Annals of Diagnostic Pathology
Shira Ronen, Navneet Narula, June H Koizumi, Bryan Hunt, Tamara Giorgadze
Low-grade endometrial stromal sarcoma (LGESS) is the second most common malignant mesenchymal tumor of the uterus. The most common location is the uterine corpus, but it can also primarily arise in a variety of extrauterine locations such as pelvis, ovary, abdominal cavity, vagina, and vulva. We are reporting a case of a 47-year-old female with no significant medical history who presented with multiple pulmonary nodules. Fine needle aspiration (FNA) specimen revealed spindle cell neoplasm consistent with the diagnosis of LGESS...
June 30, 2018: Annals of Diagnostic Pathology
Uta Flucke, Elise M Bekers, David Creytens, Joost M van Gorp
No abstract text is available yet for this article.
June 30, 2018: Annals of Diagnostic Pathology
Melissa M Straub, Mirna B Podoll, Stephanie N David, Georgia L Wiesner, Mohamed M Desouki
Risk-reducing salpingo-oophorectomy (RRSO) is a procedure to reduce the risk of adnexal cancer in BRCA mutation carriers and for hormonal manipulation in women with breast cancer (BC). The goal of the study is to report the frequency of subsequent BC and high-grade serous carcinoma (HGSC) following RRSO in BRCA1 and BRCA2 mutation carriers and in patients with personal history of BC with or without BRCA mutation. A series of 147 consecutive patients who received a RRSO were reviewed. Patient's age, clinical history, BC histotype, gene mutation data, incidence of post-RRSO BC and HGSC and time intervals were analyzed...
June 27, 2018: Annals of Diagnostic Pathology
Richard A Prayson
Frozen section intraoperative consultation is a well-established means of evaluating brain tumors at the time of surgery. Limitations to the procedure are also well recognized resulting in less than perfect specificity of diagnosis. This study retrospectively reviewed 424 consecutive meningioma cases (N = 310 females; mean age 57.3 years) to examine concordance between frozen section evaluation of meningioma subtype and grade as compared with the final diagnosis subtype and grade. A discrepancy between frozen section diagnosis and final diagnosis was observed in 114 (26...
August 2018: Annals of Diagnostic Pathology
Aziza E Abdelrahman, Anan Fathy, Eman A Elsebai, Nashwa Nawar, Waleed M Etman
Chemoresistance is the major obstacle to effective treatment in patients with serous ovarian carcinoma (SOC), which frequently related to the failure of chemotherapeutic agents to induce apoptosis. In this study, the immunohistochemical expression of Apaf-1, Cyclin D1, and Aquaporin-5 (AQP-5) was studied in 50 paraffin blocks of SOC. Data on overall survival (OS), disease-free survival (DFS) and response to the first-line chemotherapy were collected and then statistically analyzed. Apaf-1 expression was observed in 84% of the SOC cases with a significant down-regulation with higher tumor grade, lymph node metastasis, and advanced FIGO stage...
August 2018: Annals of Diagnostic Pathology
Erik Kudela, Jozef Visnovsky, Tomas Balharek, Anna Farkasova, Pavol Zubor, Lukas Plank, Jan Danko
PURPOSE: The aim of this study was to evaluate and correlate the amplification of chromosomal regions 3q26 and 5p15 in different cytological and histological subgroups of patients and to compare the sensitivity and specificity of amplification tests with cytology, colposcopy and HPV status. METHODS: The work was conducted at the Department of Obstetrics and Gynaecology in cooperation with the Institute of Pathological Anatomy, JFM CU in Martin and UNM during years 2013-2016...
August 2018: Annals of Diagnostic Pathology
Shaomin Hu, James Szymanski, Zeina Khairy, Yungtai Lo, Yanhua Wang
Although recent technological advances, there is still discordance between mammography findings and pathologic diagnoses, especially for certain racial/ethnic populations. In this study we correlated the mammography BI-RADS categories with pathologic diagnoses, aiming to evaluate the performance of mammography in breast cancer detection in a unique poor population consisting of mostly Hispanics and African Americans. A total of 3935 female patients with a breast mammography and a subsequent breast pathology report within 90 days were retrospectively analyzed...
August 2018: Annals of Diagnostic Pathology
Kvetoslava Michalova, Petr Steiner, Reza Alaghehbandan, Kiril Trpkov, Petr Martinek, Petr Grossmann, Delia Perez Montiel, Maris Sperga, Lubomir Straka, Kristyna Prochazkova, Dana Cempirkova, Vladimir Horava, Stela Bulimbasic, Kristyna Pivovarcikova, Ondrej Daum, Ondrej Ondic, Pavla Rotterova, Michal Michal, Milan Hora, Ondrej Hes
BACKGROUND: We present a series of papillary renal cell carcinomas (PRCC) reminiscent of so-called "oncocytic variant of papillary renal cell carcinoma" (OPRCC), included in the 2016 WHO classification as a potential type 3 PRCC. OPRCC is a poorly understood entity, cytologically characterized by oncocytic cells with non-overlapping low grade nuclei. OPRCC is not genotypically distinct and the studies concerning this variant have shown an inconsistent genetic profile. The tumors presented herein demonstrated predominantly papillary/tubulopapillary architecture and differed from OPRCC by pseudostratification and grade 2-3 nuclei (Fuhrman/ISUP)...
August 2018: Annals of Diagnostic Pathology
Saba Yasir, Aziza Nassar, Rafael E Jimenez, Sarah M Jenkins, Lynn C Hartmann, Amy C Degnim, Marlene Frost, Daniel W Visscher
Some fibroepithelial lesions (FEL) of the breast are difficult to classify as cellular fibroadenoma (CFA) or benign phyllodes tumor (BPT) due to overlapping histologic features. This indeterminate group is histologically characterized by prominent stromal cellularity, mild atypia, and mitotic activity. The local recurrence potential of cellular FEL (CFEL) has been insufficiently studied. The objective of this study was to evaluate the histologic features, characterize the long-term follow-up and recurrence rate of CFEL, and compare this data with the recurrence rate of definitive BPT...
August 2018: Annals of Diagnostic Pathology
Edward J Gutmann
This article reports on a unique pathology department seminar series that included talks on social science and humanities topics in addition to traditional biomedical subjects. The goals, achievements, and potential of such a series are addressed via review of selected speakers and topics.
August 2018: Annals of Diagnostic Pathology
Teemu T Tolonen, Jarno Riikonen, Teuvo L J Tammela, Laura Koivusalo, Hannu Haapasalo, Paula Kujala, Antti Kaipia
No abstract text is available yet for this article.
August 2018: Annals of Diagnostic Pathology
Yumi A Kojima, Xiaohong Wang, Hongxia Sun, Frances Compton, Michael Covinsky, Songlin Zhang
Tumor infiltrating lymphocytes (TILs) in breast cancer play an important role in predicting the outcome of breast cancer. The goal of our current study is to investigate the consistency and reproducibility of the recommendations published by the International TILs Working Group 2014 among pathology trainees and pathologists. Hematoxylin & Eosin (H&E) slides from 129 breast cancer cases (one slide each) from 2009 to 2014 were evaluated. Each case was blindly and independently reviewed by two observers following the International TILs Working Group 2014 recommendations...
August 2018: Annals of Diagnostic Pathology
Mopei Wang, Li Liang, Xiudong Lei, Asha Multani, Funda Meric-Bernstam, Debasish Tripathy, Yun Wu, Hui Chen, Hong Zhang
PURPOSE: To evaluate the incidence of cMET proto-oncogene aberration in a cohort of triple negative breast cancers using immunohistochemistry and fluorescence in situ hybridization (FISH) methods and correlated with patient outcome. PATIENTS AND METHODS: One hundred and six female patients with diagnosis of triple negative invasive breast carcinoma at The University of Texas-M D Anderson Cancer Center from 1983 to 2009 were included in the study. Expression of cMET was assessed by IHC using rabbit monoclonal anti-total cMET antibody (SP44 from Ventana)...
August 2018: Annals of Diagnostic Pathology
Michael Zaleski, Yun An Chen, Alison L Chetlen, Julie Mack, Liyan Xu, Daleela G Dodge, Dipti M Karamchandani
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental...
August 2018: Annals of Diagnostic Pathology
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