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Journal of Medical Investigation: JMI

Abe Tetsuya, Fukaya Masahide, Nagino Masato
In patients with esophageal cancer, esophageal conduit necrosis is a catastrophic complication of esophagectomy that requires surgical restoration. Because such patients are generally fatigued, less-invasive surgery is encouraged whenever possible. Therefore, we trim the sternum minimally above the healthy part of the gastric conduit, expose its surface, and then make anastomoses between the remnant esophagus and the exposed gastric conduit using a free jejunal graft through a retrosternal-subcutaneous route...
2018: Journal of Medical Investigation: JMI
Sugimoto Mayumi, Ono Akemi, Yada Keigo, Mori Hiroki, Ishibashi Hiroki, Niki Noriko, Kagami Shoji
Natural rubber latex (NRL) allergy is one of the most important causes of severe anaphylaxis during medical intervention. We report a pediatric case of latex allergy with multiple surgical histories. A 12-year-old girl developed anaphylactic shock during the pyeloplasty for ureteropelvic junction restenosis. Latex gloves or medications used during the surgery were suspected to be the cause of anaphylactic shock. We diagnosed her latex allergy on the basis of the results that serum latex-specific IgE, skin prick tests of extract from NRL gloves and recombinant Hev b 6...
2018: Journal of Medical Investigation: JMI
Nozoe Tadahiro, Nozoe Emiko, Ohga Takefumi, Ezaki Takahiro, Sueishi Katsuo
An 85-year old woman who had a large tumor in the left breast came to our out-patient clinic. Computed tomography showed multiple lung tumors in addition to a huge tumor in the left breast. A needle biopsy brought about a histological diagnosis of ductal carcinoma. A simple mastectomy was performed and a histological examination using the resected specimen demonstrated a coexistence of an adenoid structure and a false ductal structure according the histologic characteristics of adenoid cystic carcinoma, which is quite rare among breast tumors...
2018: Journal of Medical Investigation: JMI
Cho Kosai, Minami Takeya, Okuno Yoshinori, Kakuda Youhei, Tsutsumi Takahiko, Kogame Toshiaki, Ohtsuru Shigeru, Sato Norio, Koike Kaoru
Hyperbaric oxygen therapy (HBOT) for carbon monoxide (CO) poisoning is widely performed to prevent delayed neuropsychiatric syndrome. Although HBOT can generally be performed with safety, the appropriate management of HBOT still remains unestablished. A 31-year-old man was transferred to our facility to undergo HBOT in a multiplace chamber with a diagnosis of CO poisoning. The first HBOT session ended uneventfully. During the second HBOT session, the patient suddenly experienced convulsive seizures. The accompanying doctor administered intravenous propofol to stop the convulsion and terminated the HBOT...
2018: Journal of Medical Investigation: JMI
Kajiura Koichiro, Taniguchi Haruki, Ishimine Tomonari, Nakamura Kei, Ishigaki Masanobu, Fukumoto Taizo
Solitary abdominal paraaortic lymph node recurrence after radical lung cancer surgery is very rare. Here, we report a case of a solitary abdominal paraaortic lymph node recurrence of lung squamous cell carcinoma (SCC). A 63-year-old man was diagnosed with lung SCC (cT1cN0M0 stage IA3), underwent a video-assisted right lower lobectomy (ND2a-1), and the pathological findings showed SCC (pT1cN0M0 stage IA3). The EGFR mutation and ALK translocation statuses of SCC were negative, and adjuvant therapy was not performed...
2018: Journal of Medical Investigation: JMI
Numata-Uematsu Yurika, Yokoyama Hiroyuki, Sato Hiroki, Endo Wakaba, Uematsu Mitsugu, Nara Chieko, Kure Shigeo
Many studies have reported many adverse effects of children's use of media. These effects include reduced cognitive development and hyperactivity and attention disorders. Although it has been recommended that child be kept away from the media during the early developmental period, many modern parents use the media as a way to calm their children. Consequently, these children lack the opportunity to form selective attachments by reduced social engagement. These children's symptoms occasionally mimic autism spectrum disorder (ASD)...
2018: Journal of Medical Investigation: JMI
Nodera Hiroyuki, Sogawa Kazuki, Takamatsu Naoko, Mori Atsuko, Yamazaki Hiroki, Izumi Yuishin, Kaji Ryuji
Texture analysis characterizes regions in an image by their texture content and has been utilized to infer the underlying structures of medical images such as skeletal muscles. Although potentially useful in tissue diagnosis and assessing disease progression of neuromuscular diseases, the use of texture analysis in such purposes are limited, due to lack of information such as effects of aging. Thus, we performed texture analysis of medial gastrocnemius in healthy individuals form their 20s to late 80s. Among the 283 texture features in 6 classes, the features related to histogram, co-occurrence matrix, absolute gradient, and wavelet were correlated to age in 17-40% of the parameters, while none of the features related to run-length matrix and autoregressive model had significant correlation to age...
2018: Journal of Medical Investigation: JMI
Kondou Aya, Haku Mari
The aim of this study was to clarify the experiences of husbands present at their wives' emergency cesarean sections. Semi-structured interviews were conducted for nine husbands who attended their wives' emergency cesarean sections. The results were analyzed using a qualitative inductive approach. Several categories such as [wife's labor pain will be unbearable if I look], [situation was beyond one's control], and [sense of relief experienced by midwife care] were extracted from the husbands' experiences the need for an emergency cesarean section was established...
2018: Journal of Medical Investigation: JMI
Yasuoka Susumu, Miki Mari, Tsutsumi Rie, Yoshioka Masami, Bando Takashi, Michishige Fumiko
We first discovered human airway trypsin-like protease (HAT) in human mucoid sputum. Precursor HAT (47 kDa), a cell surface type Ⅱ transmembrane serine protease, is proteolyzed to mature HAT (27 kDa). Hitherto, HAT has not been detected in other biological fluids except for human sputum. We aimed to clarify whether human saliva contains mature HAT. Trypsin-like protease was isolated from saliva of healthy volunteers by a method adopted for isolation of HAT from sputum using Boc-Phe-Ser-Arg-MCA as the substrate...
2018: Journal of Medical Investigation: JMI
Kishaba Tomoo, McGill Rita, Nei Yuichiro, Ibuki Sachi, Momose Masashi, Nishiyama Kenta, Nagano Hiroaki, Yamashiro Shin
BACKGROUND: Dermatomyositis (DM) and polymyositis (PM) often have association with interstitial lung disease (ILD) which have disease specific autoantibody. METHODOLOGY: We reviewed medical records of DM/PM associated ILD from January 2000 to December 2017 according to the autoantibody. RESULT: We identified 52 patients, of whom 30 were antibody negative, 18 had anti aminoacyl-tRNA synthetases (ARS) antibodies and 4 had anti melanoma differentiation-associated gene (MDA)-5 antibody...
2018: Journal of Medical Investigation: JMI
Islam Rezwanul, Mizuguchi Hiroyuki, Shaha Aurpita, Nishida Kohei, Yabumoto Masami, Ikeda Hisashi, Fujino Hiromichi, Kitamura Yoshiaki, Fukui Hiroyuki, Takeda Noriaki
As expression level of allergic disease-sensitive genes are correlated with allergic symptom severity, suppression of these gene expressions could be good therapeutics. We have demonstrated that PKCδ signaling and NFAT signaling, involve in histamine H1 receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions...
2018: Journal of Medical Investigation: JMI
Kurai Jun, Noma Hisashi, Sano Hiroyuki, Iwata Kyoko, Tohda Yuji, Watanabe Masanari
The average annual ozone levels have been increasing in Japan, even though the high ozone levels have decreased in recent years. There is limited information on the relationship between ozone exposure, pulmonary function, and respiratory symptoms in schoolchildren in Japan. The aim of this study was to investigate the effects of short-term ozone exposure on pulmonary function and respiratory symptoms in Japanese schoolchildren. Afternoon peak expiratory flow (PEF) values and respiratory symptom scores were recorded daily in 276 schoolchildren from September to October 2016 and from January to February 2017...
2018: Journal of Medical Investigation: JMI
Nakamura Nami, Watanabe Hiroyoshi, Okamura Kazumi, Kagami Shoji
Several factors besides renal function influence serum cystatin C (CysC) levels. The present study evaluates the value of serum CysC and the equation for CysC based estimated glomerular filtration rate (CysC-eGFR) for Japanese children with malignancies. We collected information at 36 time points from 13 patients aged ≤ 17 years with malignancies. We assessed tumor activity, cell recovery phase after chemotherapy, neutropenia phase, inflammation response and medication with granulocyte-colony stimulating factor, steroid, and levothyroxine as risk factors associated with serum CysC levels...
2018: Journal of Medical Investigation: JMI
Xu Wenting, Miyamoto Licht, Aihara Haruna, Yamaoka Tomomi, Tanaka Naonobu, Tsuchihashi Yuki, Ikeda Yasumasa, Tamaki Toshiaki, Kashiwada Yoshiki, Tsuchiya Koichiro
Ectopic fat accumulation is associated with insulin resistance and type 2 diabetes mellitus. Citrus sudachi is an evergreen tree that is found mainly in Tokushima Prefecture in Japan. Previously, it was demonstrated that Citrus sudachi could inhibit the rising trend of blood glucose and fatty acid in human subjects. In the current study, we illustrated the function of methanol extracts from sudachi peel and investigated the mechanism of this effect. We got the five kinds of methanol extracts by using diaion HP-20, and those were named by hydrophobicity from M-F1 to M-F5...
2018: Journal of Medical Investigation: JMI
Yoshida Kanako, Nishimura Masato, Abe Akiko, Kato Takeshi, Furumoto Hiroyuki, Irahara Minoru
The objective of this study was to identify pathological indicators that could be used to identify a subgroup of patients with apparent stage I endometrial cancer who do require retroperitoneal lymphadenectomy. 188 T1 endometrial cancer patients underwent primary surgery at Tokushima University Hospital. We retrospectively evaluated their clinical records and histopathological factors. Systematic lymphadenectomy was performed for 149 patients, and 39 patients (grade 1 with < 5 mm of myometrial invasion) were treated without lymphadenectomy...
2018: Journal of Medical Investigation: JMI
Shimada Aki, Udaka Jiro, Nagashima Hinami, Chida Izumi, Kondo Eiji, Nakano Seiichi, Okamoto Hidehiko, Takeda Noriaki
OBJECTIVES: We examined speech recognition ability of elementary school-aged Japanese children with unilateral hearing loss under noisy environments and then examined the effects of the FM system fitted into their normal hearing ear on their speech recognition ability. METHODS: Twelve children with severe-to-profound sensorineural hearing loss and ten age-matched children with bilateral normal hearing received speech recognition test in quiet and noisy environments...
2018: Journal of Medical Investigation: JMI
Abe Hideharu, Sakurai Akiko, Ono Hiroyuki, Hayashi Sanae, Yoshimoto Sakiya, Ochi Arisa, Ueda Sayo, Nishimura Kenji, Shibata Eriko, Tamaki Masanori, Kishi Fumi, Kishi Seiji, Murakami Taichi, Nagai Kojiro, Doi Toshio
Diabetic nephropathy (DN) is the major cause of end-stage renal failure and is associated with increased morbidity and mortality as compared to other causes of renal disease. Albuminuria is often the first clinical indicator of the presence of DN. However, albuminuria or proteinuria is a common symptom in patients with various renal disorders. Therefore, specific biomarkers for the diagnosis of DN are required. A primary hallmark of DN is the progressive damage and death of glomerular podocytes, resulting in the leaking of proteins into the urine...
2018: Journal of Medical Investigation: JMI
Yamaguchi Chise, Yamanaka-Okumura Hisami, Esumi Haruka, Masuda Masashi, Katayama Takafumi, Taketani Yutaka
Humans have a high preference for fat, and its excessive intake leads to obesity. This study aimed to investigate the effects of dose-dependent fat intake on biological responses and postprandial appetite sensation in healthy adult subjects. Age and body mass index were 29 ± 1 years and 21.1 ± 0.4 kg/m2 , respectively. We conducted a randomized, crossover trial and measured laboratory data and appetite sensation via the visual analog scale. Each participant was provided with four different test meals. They consisted of common, basic foods and contained 75 g liquid glucose and 4 slices of crackers to which 0 g butter (control), 10 g butter (B10), 20 g butter (B20), and 40 g butter (B40) were added, respectively...
2018: Journal of Medical Investigation: JMI
Otani Tomoko, Kase Yasuko, Kunitomo Kazufumi, Shimooka Kazumi, Naoe Mitsugu, Yamamoto Hiroko, Kawazoe Kazuyoshi, Sato Youichi, Yamauchi Aiko
In recumbent elderly patients, creatinine clearance (eCCr) estimated by the Cockcroft-Gault (CG) equation may not necessarily reflect renal function. We aimed to develop a novel formula to revise the CG equation using anthropometric measurements in bedridden elderly patients and evaluate its clinical utility. The subjects included 77 bedridden Japanese patients aged ≦ 65, hospitalized at Naruto Yamakami Hospital. The actual CCr (mCCr) value was measured using the 24-hour urine collection method. Anthropometric data, such as skeletal muscle mass, body fat mass (BFM), and triceps skinfold thickness (TSF), were collected...
2018: Journal of Medical Investigation: JMI
Nozoe Tadahiro, Kono Mayuko, Hashimoto Naotaka, Tsujita Eiji, Kuma Sosei, Ohga Takefumi
PURPOSE: The aim of this study was to develop prognostic criteria based on the combination of nodal metastasis and preoperative elevation of serum C-reactive protein (CRP) for patients with gastric carcinoma that have been treated with curative resection. METHODS: Three hundred and twenty patients with gastric carcinoma who had been treated with curative resection were enrolled. One point was provided for each incidence of nodal metastasis and preoperative elevation of serum CRP and we examined whether this cumulative score system could provide a strict stratification of survival...
2018: Journal of Medical Investigation: JMI
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