journal
MENU ▼
Read by QxMD icon Read
search

Journal of Medical Investigation: JMI

journal
https://www.readbyqxmd.com/read/28955007/phase-i-study-of-combined-therapy-with-vorinostat-and-gefitinib-to-treat-bim-deletion-polymorphism-associated-resistance-in-egfr-mutant-lung-cancer-victroy-j-a-study-protocol
#1
Shinji Takeuchi, Kenichi Yoshimura, Tadami Fujiwara, Masahiko Ando, Shinobu Shimizu, Katsuhiko Nagase, Yoshinori Hasegawa, Toshiaki Takahashi, Nobuyuki Katakami, Akira Inoue, Seiji Yano
The BIM deletion polymorphism is reported to be associated with poor outcomes of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) treated with EGFR-TKIs, including gefitinib. We have shown that a histone deacetylase inhibitor, vorinostat, can epigenetically restore BIM function and apoptosis sensitivity to EGFR-TKIs in EGFR-mutant NSCLC cells with BIM deletion polymorphisms. The purpose of this study is to determine the feasibility of combined treatment of vorinostat with gefitinib in BIM deletion polymorphism positive EGFR-mutant NSCLC patients...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955006/phase-i-ii-study-of-alectinib-in-lung-cancer-with-ret-fusion-gene-study-protocol
#2
Shinji Takeuchi, Toshinori Murayama, Kenichi Yoshimura, Takahiro Kawakami, Shizuko Takahara, Yasuhito Imai, Yoshikazu Kuribayashi, Katsuhiko Nagase, Koichi Goto, Makoto Nishio, Yoshinori Hasegawa, Miyako Satouchi, Katsuyuki Kiura, Takashi Seto, Seiji Yano
BACKGROUND: The rearranged during transfection (RET) fusion gene was discovered as a driver oncogene in 1-2% of non-small cell lung cancers (NSCLCs). Alectinib is an approved anaplastic lymphoma kinase (ALK) inhibitor that may also be effective for RET fusion-positive NSCLC. METHODS/DESIGN: RET fusion-positive NSCLC patients treated with at least one regimen of chemotherapy are being recruited. In step 1, alectinib (600 or 450 mg, twice daily) will be administered following a 3+3 design...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955005/accurate-diagnosis-of-chronic-low-back-pain-in-a-high-level-college-athlete-a-case-report
#3
Kenji Yokoyama, Kazuta Yamashita, Masatoshi Morimoto, Fumitake Tezuka, Fumio Hayashi, Yoichiro Takata, Toshinori Sakai, Kosaku Higashino, Takashi Chikawa, Hiroshi Yonezu, Akihiro Nagamachi, Koichi Sairyo
A 21-year-old woman who was high-level college softball player presented with a 6-month history of low back pain that had been treated unsuccessfully by medication at local clinics. There was tenderness in the left paravertebral muscle at the lower lumbar level. X-ray and computed tomography revealed congenital scoliosis and an L6 hemivertebra. Short tau inversion recovery magnetic resonance imaging showed a fluid collection at the left L6-S1 facet joint. We performed a diagnostic facet injection, consisting of 1% lidocaine and steroids, that was infiltrated into the left facet joint at L6-S1...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955004/successful-treatment-of-mixed-mainly-cancer-pain-by-tramadol-preparations
#4
Shinji Kawahito, Tomohiro Soga, Naoji Mita, Shiho Satomi, Hiroyuki Kinoshita, Tomoko Arase, Akira Kondo, Hitoshi Miki, Kazumi Takaishi, Hiroshi Kitahata
The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in her face and lower limbs, she was troubled by a trigeminal neuralgia-like prominence ache...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955003/bilateral-leg-ulcers-secondary-to-dystrophic-calcinosis-in-a-patient-with-rheumatoid-arthritis
#5
Tetsuya Hida, Mitsuyoshi Minami, Yoshiaki Kubo
Calcinosis cutis can be classified into four subtypes: dystrophic, metastatic, idiopathic, and iatrogenic. Of these subtypes, dystrophic calcinosis (DC) is the most common, and is most frequently associated with connective tissue disease, particularly dermatomyositis and systemic sclerosis, and less commonly with systemic lupus erythematosus. However, DC associated with rheumatoid arthritis (RA) is extremely rare. In this paper, we present a Japanese woman with RA, who suffered from bilateral leg ulcers secondary to DC...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955002/the-case-of-double-primary-lung-adenocarcinomas-with-an-egfr-mutation-and-alk-translocation-successfully-treated-with-alectinib-at-the-post-surgical-recurrence
#6
Yoshio Tsunezuka, Nobuyoshi Tanaka, Hideki Fujimori, Yuki Togashi, Satoko Baba, Kengo Takeuchi, Kazuyoshi Katayanagi, Hiroshi Kurumaya, Hironori Kitade, Shinji Atagi, Seiji Yano
A 36-year-old male was found two nodules in the right lower lobe of the lung. After the surgical resection, both lesions were diagnosed as invasive adenocarcinomas. One lesion was primarily lepidic growth component with EGFR-L858R mutation, and the other was micropapillary component with ALK translocation accompanying mediastinal lymphnode metastases. While he experienced disease recurrence, the disease was controlled by an ALK inhibitor, given based on the findings of surgical specimens. This is the first case who had two simultaneous lung cancers with EGFR mutation and ALK translocation in each respective lesion, and was successfully treated with ALK inhibitor at the post-surgical recurrence...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955001/aggressive-resection-of-metachronous-triple-biliary-cancer
#7
Masato Yoshikawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saito, Shinichiro Yamada, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto, Mitsuo Shimada
Radical resection of recurrent cholangiocellular carcinoma (CCC) is rare. To date, only two patients have been reported to undergo major hepatectomy twice after pancreatoduodenectomy (PD) for metachronous CCC. This report describes a patient who underwent three metachronous radical resections of CCC with curative intent, consisting of PD followed by two hepatectomies, for cancer of the middle bile duct. A 60 year old male, who had undergone a distal gastrectomy for duodenal ulcer perforation in 23 years ago, underwent PD (Honjo method) for middle bile duct cancer (papillary adenocarcinoma) in 20 years ago at another hospital...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28955000/levetiracetam-improves-symptoms-of-multiple-chemical-sensitivity-case-report
#8
Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Kazuhiro Kato, Nobukazu Nakasato
Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954999/percutaneous-full-endoscopic-lumbar-foraminoplasty-for-adjacent-level-foraminal-stenosis-following-vertebral-intersegmental-fusion-in-an-awake-and-aware-patient-under-local-anesthesia-a-case-report
#9
Kazuta Yamashita, Kosaku Higashino, Toshinori Sakai, Yoichiro Takata, Fumio Hayashi, Fumitake Tezuka, Masatoshi Morimoto, Takashi Chikawa, Akihiro Nagamachi, Koichi Sairyo
Percutaneous endoscopic surgery for the lumbar spine has become established in the last decade. It requires only an 8 mm skin incision, causes minimal damage to the paravertebral muscles, and can be performed under local anesthesia. With the advent of improved equipment, in particular the high-speed surgical drill, the indications for percutaneous endoscopic surgery have expanded to include lumbar spinal canal stenosis. Transforaminal percutaneous endoscopic discectomy has been used to treat intervertebral stenosis...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954998/solitary-distant-peritoneal-metastasis-of-cecal-cancer-after-laparoscopic-colectomy-a-case-report
#10
Akira Ouchi, Koji Komori, Kenya Kimura, Takashi Kinoshita, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuichi Ito, Norihisa Uemura, Seiji Natsume, Jiro Kawakami, Yasuhiro Shimizu
A 77-year-old Japanese female underwent laparoscopic ileocecal resection and lymph node dissection for cecal cancer by a previous doctor. Two years and 9 months after previous operation, contrast-enhanced computed tomography and magnetic resonance imaging with gadolinium ethoxybenzyl-L-diethylenetriamine pentaacetic acid revealed an intraperitoneal tumor at the right subphrenic fossa. 18F-fluorodeoxyglucose position emission tomography showed fluorodeoxyglucose accumulation in the tumor, and we suspected the tumor to be solitary distant peritoneal metastasis of the previous cecal cancer to the right diaphragm...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954997/paralytic-ileus-as-the-first-presentation-in-type-a-acute-aortic-dissection
#11
Naoto Fukunaga, Yasunobu Konishi, Takehiko Matsuo, Yoshiaki Saji, Tadaaki Koyama
A 78-year-old female was referred to our hospital with a diagnosis of type A acute aortic dissection. There was a history of thrombosed aortic dissection six months prior and conservative management has been performed. Enhanced computed tomography showed type A acute aortic dissection with patent false lumen limited to the ascending aorta and ileus of the small intestine. Emergency hemiarch replacement was performed under mild hypothermic circulatory arrest and selective antegrade cerebral perfusion. Due to preoperative paralytic ileus, oral intake was initiated postoperative day four...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954996/usefulness-of-a-novel-higher-brain-dysfunction-screening-test-for-evaluating-higher-brain-function-in-healthy-persons
#12
Akemi Hioka, Yoshifumi Mizobuchi, Yoshiteru Tada, Kyoko Nishi, Yasuhiko Shirayama, Shinsuke Katoh, Naoki Akazawa, Ryuji Kaji, Yutaka Ojima, Shinji Nagahiro
To accurately and rapidly screen for higher brain dysfunction, we developed a screening test named the "higher brain dysfunction screening test" (HIBRID-ST). Previous studies have reported a decrease in higher brain function with age. However, whether HIBRID-ST can detect a decrease in higher brain function in healthy persons remains unclear. We aimed to assess the usefulness of HIBRID-ST for evaluating higher brain function in healthy persons. We recruited 60 persons without physiological abnormalities and divided them into six equal groups based on their age (20s-70s)...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954995/generation-and-characterization-of-new-ccr5-tropic-hiv-1rmt-clones
#13
Naoya Doi, Yosuke Sakai, Akio Adachi, Masako Nomaguchi
To develop effective non-human primate models for coping with numerous HIV-1/AIDS studies, rhesus macaque-tropic HIV-1 (HIV-1rmt) clones with a variety of biological properties are required. Such clones, if available, are powerful tools to experimentally elucidate HIV-1 replication and pathogenicity in host individuals, and also to develop anti-HIV-1 drugs/vaccines. However, only limited numbers of HIV-1rmt clones have been currently reported. In the present study, we generated new HIV-1rmt clones carrying various CCR5-tropic env (envelope) genes by standard recombinant DNA and intracellular homologous recombination techniques...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954994/hospital-pharmacist-intervention-improves-the-quality-indicator-of-warfarin-control-a-retrospective-cohort-study
#14
Taesong An, Eiji Kose, Akihiko Kikkawa, Hiroyuki Hayashi
Background/Aims Our previous study showed that time in therapeutic range (TTR) control of warfarin therapy was negatively affected in non-valvular atrial fibrillation (NVAF) patients with heart failure. This study assesses the effect of intervention by hospital pharmacists on TTR control in Japanese NVAF patients with heart failure. Method This retrospective cohort study included NVAF patients with heart failure admitted and discharged from the cardiovascular internal medicine ward between March 2011 and July 2013...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954993/regorafenib-induces-adaptive-resistance-of-colorectal-cancer-cells-via-inhibition-of-vascular-endothelial-growth-factor-receptor
#15
Chisato Tomida, Hikaru Nagano, Naoko Yamagishi, Takayuki Uchida, Ayako Ohno, Katsuya Hirasaka, Takeshi Nikawa, Shigetada Teshima-Kondo
Recently, inhibition of tumor angiogenesis has become an important anti-cancer therapy. Tumor angiogenesis is regulated by multiple signaling pathways, including VEGF and VEGF receptor (VEGF-R), FGF and FGF receptor (FGF-R), and PDGF and PDGF receptor (PDGF-R) pathways. Thus, the antiangiogenic agents, such as regorafenib, simultaneously target those receptors on vascular endothelial cells. In addition to endothelial cells, cancer cells express the three receptors, suggesting that the antiangiogenic inhibitors affect tumor cells...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954992/nonconcordant-regulation-of-mitochondrial-respiratory-complexes-in-the-kidneys-of-5-6-nephrectomized-mice
#16
Yukie Nakashita, Tomoya Sano, Hiroaki Yoshioka, Tomoki Shimada, Ryotaro Hori, Makoto Usami, Yasuhiro Hamada
Hyperglycemia induces nonconcordant regulation of renal mitochondrial respiratory complexes, increases oxidative stress, and causes diabetic nephropathy. Hypertension is a complication associated with diabetes and involves glomerular hyperfiltration, the effects of which on mitochondrial respiratory complexes are not well understood. To investigate the effect of glomerular hyperfiltration on renal mitochondrial respiratory complexes, we used the 5/6 nephrectomized BKS. Cg-Dock7(m)+/+Lepr(db)/J, Dock7(m)+/+Lepr(db) mice (db/m-5/6Nx mice) as a model for glomerular hyperfiltration...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954991/antiangiogenic-agent-sunitinib-induces-epithelial-to-mesenchymal-transition-and-accelerates-motility-of-colorectal-cancer-cells
#17
Chisato Tomida, Naoko Yamagishi, Hikaru Nagano, Takayuki Uchida, Ayako Ohno, Katsuya Hirasaka, Takeshi Nikawa, Shigetada Teshima-Kondo
Although vascular endothelial growth factor receptor (VEGF-R)-targeted antiangiogenic agents are important treatment for a number of human malignancies, there is accumulating evidence that the therapies may promote disease progression, such as invasion and metastasis. How tumors become to promote their evasiveness remains fully uncertain. One of possible mechanisms for the adaptation may be a direct effect of VEGF-R inhibitors on tumor cells expressing VEGF-R. To elucidate a direct effect of VEGF-R-targeting drug (sunitinib), we established a human colorectal cancer cell model adapted to sunitinib...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954990/risk-factors-for-an-additional-port-in-single-incision-laparoscopic-cholecystectomy-in-patients-with-cholecystitis
#18
Kenichiro Araki, Ken Shirabe, Akira Watanabe, Norio Kubo, Shigeru Sasaki, Hideki Suzuki, Takayuki Asao, Hiroyuki Kuwano
Although single-incision laparoscopic cholecystectomy is now widely performed in patients with cholecystitis, some cases require an additional port to complete the procedure. In this study, we focused on risk factor of additional port in this surgery. We performed single-incision cholecystectomy in 75 patients with acute cholecystitis or after cholecystitis between 2010 and 2014 at Gunma University Hospital. Surgical indications followed the TG13 guidelines. Our standard procedure for single-incision cholecystectomy routinely uses two needlescopic devices...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954989/further-evidence-to-demonstrate-the-significance-of-serum-appearance-of-anti-p53-antibody-as-a-marker-for-progressive-potential-in-invasive-ductal-carcinoma-of-the-breast
#19
Tadahiro Nozoe, Emiko Nozoe, Mayuko Kono, Takefumi Ohga, Takahiro Ezaki
BACKGROUND: Serum appearance of anti-p53 antibody (p53Ab) has been reported as an indicator for progressive potential of human tumor tumors including breast cancer. But its significance in breast cancer has not been discussed fully. METHODS: Relationship between serum appearance of p53Abs and representative data accounting for progressive potential in breast cancer, nuclear grade (NG), triple negative cancer, and the cumulative score based on these two data (TGS) was investigated among 129 women with invasive ductal carcinoma (IDC) of the breast, who had been treated with surgical resection...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954988/construction-of-a-combinatorial-pipeline-using-two-somatic-variant%C3%A2-calling%C3%A2-methods%C3%A2-for-whole-exome-sequence-data-of-gastric-cancer
#20
Tomohiro Kohmoto, Kiyoshi Masuda, Takuya Naruto, Shoichiro Tange, Katsutoshi Shoda, Junichi Hamada, Masako Saito, Daisuke Ichikawa, Atsushi Tajima, Eigo Otsuji, Issei Imoto
High-throughput next-generation sequencing is a powerful tool to identify the genotypic landscapes of somatic variants and therapeutic targets in various cancers including gastric cancer, forming the basis for personalized medicine in the clinical setting. Although the advent of many computational algorithms leads to higher accuracy in somatic variant calling, no standard method exists due to the limitations of each method. Here, we constructed a new pipeline. We combined two different somatic variant callers with different algorithms, Strelka and VarScan 2, and evaluated performance using whole exome sequencing data obtained from 19 Japanese cases with gastric cancer (GC); then, we characterized these tumors based on identified driver molecular alterations...
2017: Journal of Medical Investigation: JMI
journal
journal
32890
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"