journal
MENU ▼
Read by QxMD icon Read
search

Brain Tumor Pathology

journal
https://www.readbyqxmd.com/read/29138945/glioblastoma-in-neurofibromatosis-1-patients-without-idh1-braf-v600e-and-tert-promoter-mutations
#1
Ichiyo Shibahara, Yukihiko Sonoda, Hiroyoshi Suzuki, Akifumi Mayama, Masayuki Kanamori, Ryuta Saito, Yasuhiro Suzuki, Shoji Mashiyama, Hiroshi Uenohara, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga
Pilocytic astrocytomas and low-grade gliomas are more common compared with glioblastomas in patients with neurofibromatosis 1 (NF1). A recent genome-wide analysis has shown frequent NF1 gene alterations in the mesenchymal subtype of a glioblastoma; however, little is known about clinicopathological features of glioblastomas in NF1 patients (NF1 glioblastomas). We analyzed four NF1 glioblastomas. Radiographical and intraoperative findings showed well-circumscribed tumors from surrounding brain. Pathological analysis presented a paucity of processes with an eosinophilic cytoplasm, bizarre nuclei, xanthomatous-like appearance, multinucleated giant cells, and histiocytoid appearance...
November 14, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29063976/rela-fusion-positive-anaplastic-ependymoma-molecular-characterization-and-advanced-mr-imaging
#2
LETTER
Shumpei Onishi, Fumiyuki Yamasaki, Yoshiko Nakano, Takeshi Takayasu, Vishwa Jeet Amatya, Manish Kolakshyapati, Yukio Takeshima, Takanori Hirose, Koichi Ichimura, Kazuhiko Sugiyama, Kaoru Kurisu
No abstract text is available yet for this article.
October 11, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28840403/updated-2016-who-classification-of-tumors-of-the-cns-turning-the-corner-where-molecule-meets-pathology
#3
EDITORIAL
Takashi Komori
No abstract text is available yet for this article.
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28836232/diencephalic-pediatric-low-grade-glioma-harboring-the-braf-v600e-mutation-presenting-with-various-morphologies-in-sequential-biopsy-specimens
#4
Yukitomo Ishi, Kanako C Hatanaka, Shigeru Yamaguchi, Hiromi Fujita, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
A 5-year-old boy underwent biopsy of an intra-axial calcified tumor in the hypothalamus, which was incidentally found. Based on the presence of ganglion-like cells combined with glial cell element, the pathological diagnosis was ganglioglioma. Because the tumor grew gradually in size over the next 2 years, he underwent chemotherapy with temozolomide. However, at 8 years of age, the boy developed hydrocephalus and the cystic lesion had re-grown. Endoscopic cyst fenestration and tumor biopsy was performed, and pathological diagnosis was tentatively oligodendroglioma based on the presence of tumor cells with a perinuclear halo...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28831588/encouraging-option-of-multi-staged-gross-total-resection-for-a-c11orf-rela-fusion-positive-supratentorial-anaplastic-ependymoma
#5
Taishi Nakamura, Kohei Fukuoka, Junji Ikeda, Masahiro Yoshitomi, Naoko Udaka, Reo Tanoshima, Kensuke Tateishi, Shoji Yamanaka, Koichi Ichimura, Tetsuya Yamamoto
Ependymomas are primary neuroepithelial malignancies that mainly occur during childhood, and arise from ependymal cells along the ventricular systems of the CNS. Recently, it was elucidated that two-thirds of supratentorial (ST) ependymomas harbor oncogenic fusions of RELA, whose protein product is the principal effector of canonical NF-κB signaling. RELA fusion proteins activate signaling for tumor proliferation and malignant progression, resulting in poorer prognoses in these patients compared to those in patients with other ST ependymomas...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28825187/downregulation-of-smarcb1-ini1-expression-in-pediatric-chordomas-correlates-with-upregulation-of-mir-671-5p-and-mir-193a-5p-expressions
#6
Prit Benny Malgulwar, Pankaj Pathak, Manmohan Singh, Shashank Sharad Kale, Vaishali Suri, Chitra Sarkar, Mehar Chand Sharma
Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs). Although mutation/loss of 22q has strongly established the loss of SMARCB1/INI1 in cancers, the cause in CCs remains elusive. Recent studies suggest role of miRNAs in regulation of SMARCB1/INI1 expressions. We examined 5 reported/target predicted miRNAs to SMARCB1/INI1 in SMARCB1/INI1 immunonegative and immunopositive cases, and found upregulation of miR-671-5p and miR-193a-5p in SMARCB1/INI1-immunonegative cases. Notably, these two miRNAs were significantly predicted to target TGF-β signaling, suggestive of dysregulation of developmental and osteoblast regulation pathway in CCs...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28823098/modified-rapid-immunohistochemical-staining-for-intraoperative-diagnosis-of-malignant-brain-tumors
#7
Akane Suzuki, Takashi Maruyama, Masayuki Nitta, Takashi Komori, Soko Ikuta, Takakazu Kawamata, Yoshihiro Muragaki
Rapid immunohistochemistry (R-IHC) has been developing mainly as a support technique in the rapid diagnosis of central nervous system tumors; however, there have been problems regarding instability in specimen preparation and immunostaining. To overcome the weakness of this technology, the instability of immunostaining, we developed a modified R-IHC. This was achieved by switching to 4% paraformaldehyde as the fixative solution and utilizing a commercially available Polymer Refine Detection Kit, as a high-sensitivity kit, in place of the secondary antibodies...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28815339/expression-of-large-neutral-amino-acid-transporters-lat1-and-lat2-in-medulloblastoma
#8
LETTER
Francesco Cicone, Giuseppe Minniti, Maria Antonietta Oliva, Luciano Carideo, John O Prior, Francesco Scopinaro, Felice Giangaspero, Antonietta Arcella
No abstract text is available yet for this article.
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28799062/long-term-epilepsy-associated-tumor-in-the-amygdala-of-a-16-year-old-boy-report-of-a-rare-case-having-intranuclear-filaments
#9
Yoon Jin Cha, Dong-Seok Kim, Seung-Koo Lee, Hoon-Chul Kang, Se Hoon Kim
The term "long-term epilepsy-associated tumor (LEAT)" encompasses brain lesions associated with drug-resistant epilepsy over a long duration (≥2 years). Notably, some LEATs do not fit into any of the classifications of the World Health Organization (WHO). Herein, we report a LEAT that occurred in the left amygdala of a 16-year-old patient with intractable epilepsy. Histological examination of the resected amygdala revealed diffusely infiltrating tumor cells in the cortex. Perineuronal satellitosis and perivascular aggregation of tumor cells were apparent, along with mild nuclear enlargement and cytologic atypia...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28795231/radiation-induced-gliomas-a-report-of-four-cases-and-analysis-of-molecular-biomarkers
#10
Tsunehito Nakao, Yasuo Sasagawa, Sumihito Nobusawa, Yasushi Takabatake, Hemragul Sabit, Masashi Kinoshita, Katsuyoshi Miyashita, Yasuhiko Hayashi, Hideaki Yokoo, Mitsutoshi Nakada
Radiation-induced glioma (RIG) is a rare secondary glioma. The tumors morphologically resemble their sporadically arising counterparts. Recently, the WHO classification of tumors of the central nervous system was revised to incorporate molecular biomarkers together with classic histological features. The status of molecular biomarkers in RIG, however, remains unclear. The objective of this study was to investigate if commonly accepted glioma-specific biomarkers are relevant in RIGs. Among 269 gliomas diagnosed as WHO grade 2, 3 and 4 in our institution, four were diagnosed as RIGs...
October 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28887715/tissue-microarray-analysis-for-epithelial-membrane-protein-2-as-a-novel-biomarker-for-gliomas
#11
Lawrance K Chung, Panayiotis E Pelargos, Ann M Chan, Joanna V Demos, Carlito Lagman, John P Sheppard, Thien Nguyen, Yu-Ling Chang, Seyed A Hojat, Robert M Prins, Linda M Liau, Leia Nghiemphu, Albert Lai, Timothy F Cloughesy, William H Yong, Lynn K Gordon, Madhuri Wadehra, Isaac Yang
Epithelial membrane protein-2 (EMP2) expression is noted in many human cancers. We evaluated EMP2 as a biomarker in gliomas. A large tissue microarray of lower grade glioma (WHO grades II-III, n = 19 patients) and glioblastoma (GBM) (WHO grade IV, n = 50 patients) was stained for EMP2. EMP2 expression was dichotomized to low or high expression scores and correlated with clinical data. The mean EMP2 expression was 1.68 in lower grade gliomas versus 2.20 in GBMs (P = 0.01). The percentage of samples with high EMP2 expression was greater in GBMs than lower grade gliomas (90...
September 8, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28646266/pericytes-promote-abnormal-tumor-angiogenesis-in-a-rat-rg2-glioma-model
#12
Junji Hosono, Shunichi Morikawa, Taichi Ezaki, Takakazu Kawamata, Yoshikazu Okada
In glioma angiogenesis, tumor vessels cause morphological and functional abnormalities associated with malignancy and tumor progression. We hypothesized that certain structural changes or scantiness of functional pericytes may be involved in the formation of dysfunctional blood vessels in gliomas. In this study, we performed morphological examinations to elucidate the possible involvement of pericytes in brain tumor vessel abnormalities using a rat RG2 glioma model. After implantation of RG2 glioma cells in the syngeneic rat brain, gliomas were formed as early as day 7...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28624861/hemorrhagic-ganglioglioma-of-the-third-ventricle-with-atypical-pathological-findings
#13
Yohei Miyake, Kazuhiko Mishima, Tomonari Suzuki, Jun-Ichi Adachi, Atsushi Sasaki, Ryo Nishikawa
No abstract text is available yet for this article.
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28600666/papillary-thyroid-carcinoma-metastasizing-to-anaplastic-meningioma-an-unusual-case-of-tumor-to-tumor-metastasis
#14
Sumit Das, Navjot Chaudhary, Lee-Cyn Ang, Joseph S Megyesi
Tumor-to-tumor metastasis is a relatively uncommon entity, whereby the so-called 'recipient' tumor is involved by another biologically unrelated 'donor' tumor. Intracranially, meningioma (WHO grade 1) is the most common recipient tumor, while breast and lung cancers are the most common donor tumors. We present an unusual case of intracranial tumor-to-tumor metastasis involving papillary thyroid carcinoma (PTC) believed to have metastasized to an anaplastic meningioma (WHO grade 3). The patient is a 64-year-old female with a history of PTC, whose neuroimaging, performed as part of her staging workup, revealed a right parietal scalp lesion...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28547652/histone-h3-k27m-mutations-in-adult-cerebellar-high-grade-gliomas
#15
Satoshi Nakata, Sumihito Nobusawa, Tatsuya Yamazaki, Tadashi Osawa, Keishi Horiguchi, Yasuhiro Hashiba, Hiroyuki Yaoita, Nozomi Matsumura, Hayato Ikota, Junko Hirato, Yuhei Yoshimoto, Hideaki Yokoo
Adult cerebellar high-grade gliomas (HGG) are rare and their molecular basis has not been fully elucidated. Although a diffuse midline glioma H3 K27M-mutant, a recently characterized variant of HGG, was reported to occasionally occur in the cerebellum, adult cases were rarely tested for this mutation; only five mutant cases have been reported to date. It currently remains unknown whether H3 K27M-mutant cerebellar gliomas share common histological features or have a uniformly dismal prognosis. In the present study, we assessed the prevalence of histone H3 K27M mutations in ten adult cerebellar HGG, identifying two H3F3A-mutant cases...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28447171/prevalence-and-clinicopathological-features-of-h3-3-g34-mutant-high-grade-gliomas-a-retrospective-study-of-411-consecutive-glioma-cases-in-a-single-institution
#16
Koji Yoshimoto, Ryusuke Hatae, Yuhei Sangatsuda, Satoshi O Suzuki, Nobuhiro Hata, Yojiro Akagi, Daisuke Kuga, Murata Hideki, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara
A recurrent glycine-to-arginine/valine alteration at codon 34 (G34R/V) within H3F3A, a gene that encodes the replication-independent histone variant H3.3, reportedly occurs exclusively in pediatric glioblastomas. However, the clinicopathological and biological significances of this mutation have not been completely elucidated; especially, no such data exist for tumor samples from Japanese patients. We analyzed 411 consecutive glioma cases representing patients of all ages. Our results demonstrated that 14 patients (3...
July 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28455683/preface
#17
EDITORIAL
Kazunari Yoshida
No abstract text is available yet for this article.
April 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28432450/genetic-aberrations-and-molecular-biology-of-skull-base-chordoma-and-chondrosarcoma
#18
REVIEW
Yohei Kitamura, Hikaru Sasaki, Kazunari Yoshida
Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additionally, their location at the skull base makes them problematic. Although accurate diagnosis of these tumors is important because of their distinct prognoses, distinguishing between these tumor types is difficult due to overlapping radiological and histopathological findings...
April 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28429093/a-case-of-glioblastoma-resected-immediately-after-administering-bevacizumab-consideration-on-histopathological-findings-and-safety-of-surgery
#19
Yukina Tokuda, Ryota Tamura, Kentaro Ohara, Kazunari Yoshida, Hikaru Sasaki
Surgery after administering bevacizumab should be carefully considered particularly because of wound healing concerns. A 27-year-old man presented with multiple tumor recurrences after gross total removal of a left temporal oligodendroglioma (1p/19q-noncodeleted). Whole brain radiotherapy with concomitant temozolomide and bevacizumab was immediately prescribed; however, the patient's condition deteriorated because of brain herniation. Three days after administering bevacizumab, an emergency tumor removal with external decompression and a ventriculo-peritoneal shunt was performed...
April 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28386777/bevacizumab-for-malignant-gliomas-current-indications-mechanisms-of-action-and-resistance-and-markers-of-response
#20
REVIEW
Ryota Tamura, Toshihide Tanaka, Keisuke Miyake, Kazunari Yoshida, Hikaru Sasaki
Vascular endothelial growth factor (VEGF) is an attractive target of antiangiogenic therapy in glioblastomas. Bevacizumab (Bev), a humanized anti-VEGF antibody, is associated with the improvement of progression-free survival and performance status in patients with glioblastoma. However, randomized trials uniformly suggest that these favorable clinical effects of Bev do not translate into an overall survival benefit. The mechanisms of action of Bev appear to include the inhibition of tumor angiogenesis, as well as indirect effects such as the depletion of niches for glioma stem cells and stimulation of antitumor immunity...
April 2017: Brain Tumor Pathology
journal
journal
32882
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"