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Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova

E L Gorbacheva, A S Gazarskava, E V Cherniiovskava, M V Glazova, L S Nikitina
The aim of our study was to analyze vasopressin secretion rate from hypothalamic neurons in Krushinsky-Molodkina (KM) rats prone to audiogenic epilepsy in control and during audiogenic seizures. We evaluated vasopressin content in blood serum and neurophysin II amount in the neurohypophysis in KM rats as well as in Wistar rats. Obtained data demonstrated decreasing of vasopressin in the blood and at the same time increasing of neurophysin II content in the neurohy- pophysis of KM rats that revealed an inhibition of vasopressin release into blood circuit...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
L B Shestopalova, E A Petropavlovskaia, N I Nikitin, S Ph Vaitulevich
The spectral dynamics of the EEG rhythmicity during active and passive discrimination of stationary and moving sound stimuli presented according to the oddball paradigm were investigated. Standard stimuli represented stationary midline sounds. Deviant stimuli simulated smooth and stepwise sound source motion (to the left/right from head midline) produced by linear and stepwise changes of interaural time delay. Significant changes of the brain oscillations were found in the frequency range of 3-30 Hz. The dynamics of the moving deviant stimuli (smooth vs...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
E A Ogorodnikova, E I Stolvaroya, S P Pak, G M Bogomolova, Yu N Korolev, V N Golubev, E M Lesova
The effect of normobaric hypoxic hypoxia (single and interval training) on the characteristics of human hearing was investigated. The hearing thresholds (tonal audiograms), reaction time of subjects in psychophysical experiments (pause detection, perception of rhythm and target words), and short-term auditory memory were measured before and after hypoxia. The obtained data revealed improvement of the auditory sensitivity and characteristics of working memory, and increasing of response speed. It was demonstrated that interval hypoxic training had positive effect on the processes of auditory perception...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Vekovischeva O Yu, E E Lyakso
Ethological approach was applied to compare a non-verbal behavior of the 6- and 12-month old infants having neurological diagnosis by the birth (P 91.8 according to ICD-10 scale; risk infants) with the behavior of their healthy (norm infants) peers. The double-blind controlled uninterrupted observation of 1- and 2-minute videos was done to estimate duration and sequence of behavioral elements manifested by infants in familiar home environment during everyday activity. We suggested that if the specific behavioral differences exist it would be considered as predictive markers of infant's development problems...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
E S Lebedeva, I V Dvorakovskava, N A Kuzubova, O N Titova
Effect of peptide therapy on morphological and functional characteristics of alveolar macrophages and role of their phenotypic reprogramming in modulation of pulmonary fibrosing process were evaluated on the rat's model of pulmonary fibrosis, initiated by intratracheal administration of bleomycin. Status of alveolar macrophages was evaluated on the basis of electron microscopic studies and phagocytic activity. In lung tissue of control animals widespread diffuse interstitial fibrosis was determined. Alveolar macrophage cytoplasm was filled geterophagosomes with surfactant fragments, lipid droplets and cholesterol crystals; foam cells were a third of macrophage pool...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V L Evlakhov, I Z Poyassov, E V Shaidakov
In acute experiments the pulmonary hemodynamics changes following pulmonary embolism were studied in rabbits with intact circulation and isolated lungs perfusion. In both cases the pulmonary vascular resistance increased to the same extent. The pulmonary artery pressure following pulmonary embolism in intact animals increased less, than in the case of isolated lungs perfusion, because the pulmonary artery flow decreased. The experiments with the restriction of the inferior vena cava flow have revealed that pulmonary artery pressure and flow decreased, where the pulmonary artery flow was reduced in the same level as following pulmonary embolism...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V G Aleksandrov, N P Aleksandrova, T S Tumanova, A D Evseeva, V A Merkuriev
The role of NO-ergic mechanisms in the realization of the respiratory effects of pro-inflammatory cytokine IL-1beta was investigated in acute experiments on anesthetized rats. To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
P E Umriukhin, O S Grigorchuk
In the presented study we investigated the possibility to use the open field behavior data for prediction of corticosterone level in rat blood plasma before and after stress. It is shown that the most reliable open field behavior parameters, reflecting high probability of significant upregulation of corticosterone after 3 hours of immobilization, are the short latency of first movement and low locomotor activity during the test. Rats with high corticosterone at normal non-stress conditions are characterized by low locomotor activity and on the contrary long latency period for the entrance of open field center...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V I Mironova, V V Rakitskaya, S G Pivina, N E Ordyan
The neuroendocrine mechanisms underlying anxiety-like state development in cycling female rats with different plasma estradiol levels have been studied in a stress-restress paradigm, an animal model of posttraumatic stress disorder (PTSD). The effect of stress-restress on the hypothalamic expression of corticotropin-releasing hormone (CRH) and vasopressin was analyzed by quantitative immunocytochemistry. Stress-restress was found to increase CRH expression in the hypothalamic paraventricular nucleus (PVN) on the 10th post-restress day, but the level of CRH expression in the PVN restored to the basal values on the 30th post-restress day in all experimental groups...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
N M Bazhan, E V Kulikova, E N Makarova, T V Yakovleva, A Yu Kazantseva
Melanocortin (MC) system regulates food intake under the rest conditions. Stress inhibits food intake. It is not clear whether brain MC system is involved in stress-induced anorexia in mice. The aim of the work was to investigate the effect of pharmacological blockade and activation of brain MC receptors on food intake under stress. C57B1/6J male mice were subjected to ether stress (0.5 minute ether anesthesia) before the administration of saline solution or synthetic non-selective blocker (SHU9119) or agonist (Melanotan II) of MC receptors into the lateral brain ventricle...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A S Chinkin
While night sleeps urinary noradrenaline excretion of skilled skiers less than their untrained peers, but the difference in excretion of adrenaline is not revealed. By increasing the distance and time to overcome it during skiing catecholamine excretion is increased both - totally and per minute. Most urinary catecholamines detected at a distance of 50 km in low sliding: increased excretion of adrenaline - 84 times, and noradrenaline -95 times. These results shows that high qualificated skier's functional reserve of the sympathoadrenal system, is mobilize at long competitions for ten times higher than in rest...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V N Kalaev, M S Nechaeva, O S Korneeva, D A Cherenkov
The influence of polymorphism of the serotonin transporter and monoamine oxidase A genes, associated with man's aggressiveness on the psycho-emotional state and karyological status of single combat athletes. It was revealed that the carriers of less active ("short"), monoamine oxidase A gene variant have a high motivation to succeed and less rigidity and frustrated, compared to the carriers of more active ("long") version of the gene. Heterozygote carriers of less active ("short") variant of the serotonin transporter gene 5-HTTL had more physical aggression, guilt and were less frustrated compared with carriers of two long alleles...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
T M Mirzoev, S A Tyganov, Yu N Lomonosova, P E Musienko, B S Shenkman
The impact of mechanical unloading (hindlimb suspension for 1-, 3- and 7 days) on the protein synthesis intensity and as well as intracellular signaling pathways controlling mRNA translation was investigated. The content of the key signaling molecules of the various anabolic signaling pathways was determined by Western-blotting. The rate of protein synthesis was assessed using in vivo SUnSET technique. Hindlimb suspension (HS) within 24 hours resulted in a significant (p < 0.05) decrease in p-4E-BP 1 content and increase in p-p70s6k content in soleus muscle...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A A Borzykh, I V Kuzmin, E A Lysenko, A P Sharova, O S Tarasova, O L Vinogradova
A comparative analysis of the signaling pathways activity and gene expression in the red (RG) and white (WG) parts of the gastrocnemius muscle of rat after a series of short (1 s) tetanic contractions induced by motor nerve stimulation at a frequency of 100 Hz and with an amplitude that provides activation of all motor units of the muscle. WG compared to RG demonstrated a marked increase in the phosphorylation level of ERK1/2, although the increase in the phosphorylation of AMPK was not different in two muscles 2 h after the stimulation...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
S Yu Zhilyaev, A N Moskvin, T F Platonova, I T Demchenko
The activation of autonomic afferents (achieved through the vagus nerve (VN) electrical stimulation) on CNS O2 toxicity and cardiovascular function was investigated. In conscious rabbits at 5 ATA 02, prodromal signs of CNS O2 toxicity and convulsion latency were determined with and without vagus nerve (VN) stimulation. EEG, ECG and respiration were also recorded. In rabbits at 5 ATA, sympathetic overdrive and specific patterns on the EEG (synchronization of slow-waves), ECG (tachycardia) and respiration (respiratory minute volume increase) preceded motor convulsions...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
N K Popova, E G Ponimaskin, V S Naumenko
Recent studies considerably extended our knowledge of the mechanisms and physiological role of the interaction between different receptors in the brain. Current review summarizes data on the formation of receptor complexes and the role of such complexes in the autoregulation of the brain serotonin system, behavioral abnormalities and mechanism of antidepressants action. Particular attention is paid to 5-HT1A and 5-HT7 receptor heterodimers. The results described in the present review indicate that: i) dimerization and formation of mobile receptor complexes is a common feature for the members of G-protein coupled receptor superfamily; ii) 5-HT7 receptor appears to be a modulator for 5-HT1A receptor - the key autoregulator of the brain serotonin system; iii) 5-HT1A/5-HT7 receptor complexes formation is one of the mechanisms for inactivation and desensitization of the 5-HTIA receptors in the brain; iv) differences in the 5-HT7 receptor and 5-HTIA/5-HT7 heterodimers density define different sensitivity of pre- and postsynaptic 5-HTlA receptors to chronic treatment with selective serotonin reuptake inhibitors...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A N Inyushkin, A A Petrova, M A Tkacheva, E M Inyushkina
In the experiments on sagittal hypothalamic slices of male Wistar rats, the effect of 10 nM neuropeptide Y on the electrical activity of the suprachiasmatic nucleus neurons and spike information coding parameters were studied. Applications of neuropeptide Y induced a reduction of action potential frequency in 35 of 81 tested neurons, in 8 cells an increase in the parameter was observed; the remaining 38 neurons did not change their spike activity level. The decrease in spike frequency generation by neurons of the suprachiasmatic nucleus accompanied by an increase in both entropy of interspike interval distribution and mutual information between adjacent interspike intervals...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A A Aleksandrov, V Yu Shteinikov
The present article accesses the dependence of mismatch negativity of the human auditory event related potentials on the length of interstimulus interval. We employed passive oddball paradigm as a presentation method and simple tones were used as stimuli. This study was based on the assumption, that storage time of the memory trace, which is used for generation of mismatch negativity, is dependent on the length of the stimulus itself. As a result, the mismatch negativity was registered for short durations 11 ms stimuli...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
I N Abdurasulova, E A Tarasova, A V Matsulevich, A V Eliseev, E I Ermolenko, A N Suvorov, V M Klimenko
In this study, on the model of multiple sclerosis - experimental allergic encephalomyelitis (EAE), the dynamics of changes in the qualitative and quantitative composition of the intestinal microbiota in rats with symptoms of the disease and asymptomatic course were compared. It was found that the composition of the intestinal microbiota in rats with the clinical symptoms of EAE is shifted towards gram-negative opportunistic microorganisms of the genus Citrobacter, Prote- us, Klebsiella and enteropathogenic Escherichia coli...
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Yu M Zakharov
The review describes the induction of erythropoietin gene expression in liver, reproouctive and hemopoietic systems during hypoxia or a state of proliferation.
November 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
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