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Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova

L V Kapilevich, Yu P Bredikhina
With an increase of sports qualification dancers are developing asymmetry of parameters of bioelectric activity and hemodynamic of the legs. For beginners sportsmen are characteristic coordination of movements performed individually, while highly skilled dancers better coordination of movements, performed in tandem. For the average skill level of athletes characteristically is overvoltage vegetative-vascular system. All of the above allows us to consider the formation of skills in ballroom dancing as a functional system in which a sense of balance and coordination are determining for the skill level of athletes, linked to the information field of the visual and vestibular reception, to the organization of the contractile activity of muscles and vegetative-vascular maintenance activities...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A V Gribanov, D M Fedotov, L A Mel'kova
No abstract text is available yet for this article.
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A A Aleksandrov, N V Polyakova, O A Rudenko
In this study, we investigated a question about a possibility to form involuntary auditory-visual associations in children (8-11 yrs) during discriminations of speech sounds (phonemes) when they presented simultaneously with visual stimuli. It was used two types of static images - geometrical figures and images of hand gestures. We judge about the formation of auditory-visual association by behavioral disturbance (reaction time, percentage of wrong reactions during discriminations of phonemes) after changes in experimental protocol viz, partial substitution of preceding pairs of stimuli which were used during training to form auditory-visual associations for the new combinations of previous images and sounds...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
T A Zapara, A L Proskura, I A Malakhin, S O Vechkapova, A S Ratushnyak
A time dynamic of LTP development in the first minutes after high frequency stimulation has been investigated by using a cell model of synaptic potentiation. An experimental assessment of dependence of potentiation and maintenance of a stable level of synaptic transmission in the CA1 area of mice hippocampus on the intracellular transport has been made with brefeldin A (the blocker of transport vesicle forming). The integrative activity of the systems, ensuring the delivery of glutamate receptors to the dendrite spines in amounts and in time intervals necessary for fast changing and long maintenance of transmission efficiency is discussing...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
S V Gein, I L Sharav'eva
The effect of 10- and 60-min cold stress was analyzed on reactive oxygen species (ROS) formation, peritoneal macrophage production of cytokines and corticosterone level under the opiate receptor blockade. It was observed that mice exposed to -20 °C for 10 min demonstrated the ROS inhibition, the effect was leveled against the background of naloxone introduction. The animal group subjected to 60-min stress on the contrary, showed the naloxone-dependent promotion of ROS product. Both variants of cold stress did not render significant effect on IL-1ß production...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V N Shipilov, A M Trost, O V Chistyakova, K V Derkach, A O Shpakov
Diabetic peripheral neuropathy (DPN) is one of the most common complications of the type 1 diabetes mellitus (DM1). The aim of the work was to study the dynamics of a painful DPN and functional state of the hormone-sensitive ACSS in the skeletal muscles of rats with the models of acute and mild DM1, as well as the study of impact on them of insulin therapy with different ways of hormone delivery - intranasal and peripheral. In both models of DM1, the level of nociceptive threshold in rats decreased and the stimulatory effects of guanine nucleotides (GppNHp) and adrenergic agonists (isoproterenol, BRL-37344) on adenylyl cyclase (AC) activity were attenuated...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A A Spasov, D S Yakodev, A A Brigadirova
On the basis of the experimental model of angiotensin (Ang) II-induced vasoconstriction by means of the pharmacological agents with various mechanisms of vasoactive action (including verapamil, lidocaine, papaverine, atropine, phentolamine) dependence of Ang II-mediated vascular effect on the state of L-type voltage-dependent calcium channels, voltage-gated sodium channels, phosphodiesterase 3, acetylcholine muscarinic receptors, α-adrenergic receptors were investigated. As a result of the detailed studying of mechanisms of Ang II-mediated vascular effect, it was confirmed that Ang II-induced contraction of isolated rat portal vein depends on the influx of extracellular Ca 2+ through L-type voltage-dependent calcium channels, is less dependent on the phosphodiesterase 3 activity, but it's not dependent on the functional properties of voltage-gated sodium channels, acetylcholine muscarinic receptors and α-adrenergic receptors...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V F Maksimov, I M Korostyshevskaya, N S Rudenko, A L Markel
The pioneer overall ultrastructural and immune-enzymatic evaluation of the secretory activity of atrial myoendocrine cells in WAG strain (control) and in ISIAH rats with inherited stress induced arterial hypertension has been carried out. It was revealed that under basal conditions the cardiac hormone synthesis, storage and secretion in myoendocrine cells of hypertensive rats were certainly intensified, and the atrial natriuretic peptide (ANP) blood concentration was reliably higher than in normotensive WAG rats...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
N S Logvinenko, L E Katlova, E I Solenov, L N Ivanova
The involvement of wortmannin (10 -5 M), phosphatidyl inositol 3-kinase (PI3K) blocker, in the implementation of the rapid nongenomic aldosterone (10 nM) effects on the intracellular sodium (Na i +) and the principal cell volume of cortical collecting duct (CCD) of 10-day and adult rat kidney CCD was studied. Using fluorescence microscopy with intracellular dye Na Green and Calcein we found that wortmannin weakened the effect of aldosterone on the Na i + at low sodium in the extracellular medium (14 mM NaCl), and slowed the rate of reduction of the principal cell volume in the presence of aldosterone at the hypoosmotic shock (240/140 mOsm) since 10 days of age...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
A D Nozdrachyov, V I Tsirkin, Yu V Korotaeva
The first part of the review presents data on localization of alpha 1-adrenoceptor (AR) in the heart, including plasma and nuclear membranes, on its relative concentrations in the myocardium, on three alpha1-AR (A-, B- and D-) subtypes, the two of which (A and B) are mainly expressed in the human and mouse myocardium and all the three subtypes are expressed in rat''s myocardium. It also reports that the activation of alpha 1-AR induces inotropic effect (positive, negative or biphasic), luzitropic effect, chronotropic effect (the latter can be also positive or negative), and arrhythmogenic effects...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V N Mukhin, K I Pavlov, V M Klimenko
One of the main elements of the pathogenesis of Alzheimer's disease is neuronal loss in different areas of the brain, which is more intensive than in normal aging. Necessity of studying the pathogenesis of this process is determined by the fact that the loss of neurons begins at the preclinical stage of Alzheimer's disease when the amyloid plaques and neurofibrillary tangles (main morphological manifestations of the disease) is not yet formed and that the loss of neurons correlates with the severity of clinical symptoms...
February 2016: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
E L Gorbacheva, A S Gazarskava, E V Cherniiovskava, M V Glazova, L S Nikitina
The aim of our study was to analyze vasopressin secretion rate from hypothalamic neurons in Krushinsky-Molodkina (KM) rats prone to audiogenic epilepsy in control and during audiogenic seizures. We evaluated vasopressin content in blood serum and neurophysin II amount in the neurohypophysis in KM rats as well as in Wistar rats. Obtained data demonstrated decreasing of vasopressin in the blood and at the same time increasing of neurophysin II content in the neurohy- pophysis of KM rats that revealed an inhibition of vasopressin release into blood circuit...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
L B Shestopalova, E A Petropavlovskaia, N I Nikitin, S Ph Vaitulevich
The spectral dynamics of the EEG rhythmicity during active and passive discrimination of stationary and moving sound stimuli presented according to the oddball paradigm were investigated. Standard stimuli represented stationary midline sounds. Deviant stimuli simulated smooth and stepwise sound source motion (to the left/right from head midline) produced by linear and stepwise changes of interaural time delay. Significant changes of the brain oscillations were found in the frequency range of 3-30 Hz. The dynamics of the moving deviant stimuli (smooth vs...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
E A Ogorodnikova, E I Stolvaroya, S P Pak, G M Bogomolova, Yu N Korolev, V N Golubev, E M Lesova
The effect of normobaric hypoxic hypoxia (single and interval training) on the characteristics of human hearing was investigated. The hearing thresholds (tonal audiograms), reaction time of subjects in psychophysical experiments (pause detection, perception of rhythm and target words), and short-term auditory memory were measured before and after hypoxia. The obtained data revealed improvement of the auditory sensitivity and characteristics of working memory, and increasing of response speed. It was demonstrated that interval hypoxic training had positive effect on the processes of auditory perception...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Vekovischeva O Yu, E E Lyakso
Ethological approach was applied to compare a non-verbal behavior of the 6- and 12-month old infants having neurological diagnosis by the birth (P 91.8 according to ICD-10 scale; risk infants) with the behavior of their healthy (norm infants) peers. The double-blind controlled uninterrupted observation of 1- and 2-minute videos was done to estimate duration and sequence of behavioral elements manifested by infants in familiar home environment during everyday activity. We suggested that if the specific behavioral differences exist it would be considered as predictive markers of infant's development problems...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
E S Lebedeva, I V Dvorakovskava, N A Kuzubova, O N Titova
Effect of peptide therapy on morphological and functional characteristics of alveolar macrophages and role of their phenotypic reprogramming in modulation of pulmonary fibrosing process were evaluated on the rat's model of pulmonary fibrosis, initiated by intratracheal administration of bleomycin. Status of alveolar macrophages was evaluated on the basis of electron microscopic studies and phagocytic activity. In lung tissue of control animals widespread diffuse interstitial fibrosis was determined. Alveolar macrophage cytoplasm was filled geterophagosomes with surfactant fragments, lipid droplets and cholesterol crystals; foam cells were a third of macrophage pool...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V L Evlakhov, I Z Poyassov, E V Shaidakov
In acute experiments the pulmonary hemodynamics changes following pulmonary embolism were studied in rabbits with intact circulation and isolated lungs perfusion. In both cases the pulmonary vascular resistance increased to the same extent. The pulmonary artery pressure following pulmonary embolism in intact animals increased less, than in the case of isolated lungs perfusion, because the pulmonary artery flow decreased. The experiments with the restriction of the inferior vena cava flow have revealed that pulmonary artery pressure and flow decreased, where the pulmonary artery flow was reduced in the same level as following pulmonary embolism...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V G Aleksandrov, N P Aleksandrova, T S Tumanova, A D Evseeva, V A Merkuriev
The role of NO-ergic mechanisms in the realization of the respiratory effects of pro-inflammatory cytokine IL-1beta was investigated in acute experiments on anesthetized rats. To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
P E Umriukhin, O S Grigorchuk
In the presented study we investigated the possibility to use the open field behavior data for prediction of corticosterone level in rat blood plasma before and after stress. It is shown that the most reliable open field behavior parameters, reflecting high probability of significant upregulation of corticosterone after 3 hours of immobilization, are the short latency of first movement and low locomotor activity during the test. Rats with high corticosterone at normal non-stress conditions are characterized by low locomotor activity and on the contrary long latency period for the entrance of open field center...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
V I Mironova, V V Rakitskaya, S G Pivina, N E Ordyan
The neuroendocrine mechanisms underlying anxiety-like state development in cycling female rats with different plasma estradiol levels have been studied in a stress-restress paradigm, an animal model of posttraumatic stress disorder (PTSD). The effect of stress-restress on the hypothalamic expression of corticotropin-releasing hormone (CRH) and vasopressin was analyzed by quantitative immunocytochemistry. Stress-restress was found to increase CRH expression in the hypothalamic paraventricular nucleus (PVN) on the 10th post-restress day, but the level of CRH expression in the PVN restored to the basal values on the 30th post-restress day in all experimental groups...
December 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
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