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International Journal of Clinical Practice

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https://www.readbyqxmd.com/read/28758319/treatment-options-for-unresectable-hcc-with-a-focus-on-sirt-with-yttrium-90-resin-microspheres
#1
REVIEW
Eric A Wang, Jeff P Stein, Ross J Bellavia, Scott R Broadwell
Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is the second leading cause of cancer-related deaths across the globe. Only a small percentage of HCC patients (~20%-30%) are diagnosed at an early stage when first-line treatment options may be effective. The majority of HCC patients (>70%) are diagnosed with unresectable disease and given a poor overall prognosis. Current treatment guidelines recommend locoregional therapy with transarterial chemoembolisation (TACE) and systemic therapy with sorafenib as first-line treatment for patients with intermediate and advanced stage HCC...
July 30, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28758307/random-blood-glucose-screening-at-a-public-health-station-encouraged-high-risk-subjects-to-make-lifestyle-changes
#2
Karin Elman, Julio Wainstein, Mona Boaz, Daniela Jacubovitz, Yosefa Bar-Dayan
BACKGROUND: Screening and early diagnosis of prediabetes and diabetes can prevent or delay disease onset and complications. To that end, a free public health station was established in a large, government medical centre. This study evaluated the long-term outcomes of abnormal random blood glucose results among patients with no history of diabetes or prediabetes. METHODS: The Diabetes Unit supervised a public dysglycaemia and hypertension screening station. Participants with blood glucose >140 mg/dL and no history of diabetes or prediabetes were contacted by telephone for follow-up...
July 30, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750477/anti-pcsk9-antibodies-for-hypercholesterolaemia-overview-of-clinical-data-and-implications-for-primary-care
#3
REVIEW
Olivier S Descamps, Uwe Fraass, Ricardo Dent, Winfried März, Ioanna Gouni-Berthold
OBJECTIVES: To put data from our recent systematic review of phase 3 studies of anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies into the context of clinical practice. METHODS: Data from studies previously identified by a systematic review of phase 3 studies of alirocumab and evolocumab and additional references from non-systematic literature searches were used. We evaluated the hypothetical cardiovascular (CV) benefit in cases of typical patients in whom anti-PCSK9 antibodies may be recommended, using preliminary major CV event (CVE) rates from long-term clinical trials of anti-PCSK9 antibodies and from extrapolations derived from correlation between low-density lipoprotein cholesterol (LDL-C) reduction and CV benefit with other lipid-lowering therapies (LLTs)...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750476/haematuria-work-up-in-general-care-a-german-observational-study
#4
Andreas Eisenhardt, Daniel Heinemann, Herbert Rübben, Jochen Heß
BACKGROUND: Haematuria is a common finding in the population and the diagnostic workflow of this symptom represents a large proportion of "work-load" in the urological outpatient clinic. AIMS: The intention of this study was to verify if the intensive diagnostic procedures of haematuria patients is justified by detection of a significant proportion of genito-urinary tract cancers. MATERIALS AND METHODS: In a retrospective design 1049 consecutive patients, who presented themselves with macro- or microhaematuria in the outpatient clinic PURR in the time from 2011 to 2012, were included in the study and the diagnostic procedures including ultrasound, intravenous urography, computed tomography of the abdomen and urethrocystoscopy as well as therapeutic consequences with its results were analysed...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750475/inpatient-glucose-management-programme-in-the-asian-healthcare-setting
#5
Du Soon Swee, Li Chang Ang, Wee May Heng, Desmond Xue-Yuan Lee, Xiaohui Xin, Shalini Kumaran, Kok Seng Wong, Yong Mong Bee, Su-Yen Goh, Ming Ming Teh
AIM: To implement an inpatient glucose management (IGM) programme in the general medical wards and evaluate its clinical efficacy. METHOD: Consecutive patients admitted to selected medical wards over a 12-month period were included in the IGM programme. All patients with ≥3 capillary blood glucose (CBG) readings (>10.0 mmol/L and/or <4.0 mmol/L) over a 24-hour period were identified electronically. A multidisciplinary team of diabetes care providers would provide specialist input to these patients...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28735508/initiating-insulin-how-to-help-people-with-type-2-diabetes-start-and-continue-insulin-successfully
#6
William H Polonsky, Joyce Arsenault, Lawrence Fisher, Pamela Kushner, Eden M Miller, Teresa L Pearson, Mariusz Tracz, Stewart Harris, Norbert Hermanns, Bernd-M Scholz, Robyn K Pollom, Magaly Perez-Nieves, Roy Daniel Pollom, Irene Hadjiyianni
No abstract text is available yet for this article.
July 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28722795/influence-of-renal-function-on-anticoagulation-control-in-patients-with-non-valvular-atrial-fibrillation-taking-vitamin-k-antagonists
#7
José M Lobos-Bejarano, Angel Castellanos Rodríguez, Vivencio Barrios, Carlos Escobar, José Polo-García, José Carlos Del Castillo-Rodríguez, Diego Vargas-Ortega, Adriana Lopez-Pineda, Luis Prieto-Valiente, Gregory Y H Lip
BACKGROUND AND PURPOSE: Chronic kidney disease (CKD) has been related to poor anticoagulation control and an increased risk of bleeding. This study aims to evaluate the association between impaired renal function (eGFR <60 mL/min/1.73 m(2) ) and anticoagulation control in patients with non-valvular atrial fibrillation (AF) on vitamin K antagonists (VKA) therapy. We also assessed whether the predictive value of the SAMe-TT2 R2 score prevailed for subgroups both with and without CKD...
July 19, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28722790/switching-to-a-rilpivirine-emtricitabine-tenofovir-single-tablet-regimen-in-rna-suppressed-patients-infected-with-human-immunodeficiency-virus-1-effectiveness-safety-and-costs-at-96%C3%A2-weeks
#8
Paula Arrabal-Durán, Carmen G Rodríguez-González, Esther Chamorro-de-Vega, Paloma Gijón-Vidaurreta, Ana Herranz-Alonso, María Sanjurjo-Sáez
OBJECTIVES: This study evaluates the effectiveness, safety and costs of switching to a rilpivirine/emtricitabine/tenofovir disoproxil fumarate (RPV/FTC/TDF) regimen in treatment-experienced HIV-1-infected patients with sustained virological suppression. METHODS: Observational, prospective study. Study population included all treatment-experienced patients with sustained virological suppression who switched to RPV/FTC/TDF during 2013 in a tertiary hospital. Patients were followed until they completed 96 weeks of treatment...
July 19, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28618177/assessing-the-quality-of-primary-care-referrals-to-surgery-of-patients-with-diabetes-in-the-east-of-england-a-multi-centre-cross-sectional-cohort-study
#9
Dimitri J Pournaras, Evangelos S Photi, Nicholas Barnett, Christopher P Challand, Nikolaos A Chatzizacharias, Nokwanda P Dlamini, Triantafyllos Doulias, Aoibhinn Foley, James Hernon, Bhaskar Kumar, Jack Martin, Ian Nunney, Ioanna Panagiotopoulou, Neel Sengupta, Oshini Shivakumar, Piriyah Sinclair, Phil Stather, Miriam M Than, Antonia C Wells, Athanasios Xanthis, Ketan Dhatariya
AIM: Peri-operative hyperglycaemia is associated with an increased incidence of adverse outcomes. Communication between primary and secondary care is paramount to minimise these harms. National guidance in the UK recommends that the glycated haemoglobin (HbA1c) should be measured within 3 months prior to surgery and that the concentration should be less that 69 mmol/mol (8.5%). In addition, national guidance outlines the minimum dataset that should be included in any letter at the time of referral to the surgeons...
June 15, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28618134/potentially-inappropriate-use-of-furosemide-in-a-very-elderly-population-an-observational-study
#10
Carla Rodriguez-Cillero, Didier Menu, Philippe d'Athis, Sophie Perrin, Mélanie Dipanda, Sanaa Asgassou, Hélène Guepet, Emmanuel Mazen, Patrick Manckoundia, Alain Putot
OBJECTIVE: Little is known about furosemide prescription modalities in elderly people. We describe furosemide prescription in ambulatory elderly patients. METHODS: All patients aged over 80 years, affiliated to Mutualité Sociale Agricole de Bourgogne, a French regional health insurance plan, with a medical prescription delivered in March 2015, were retrospectively included. RESULTS: Among 15 141 patients with a median age of 86 years, comprising 61...
June 15, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28618132/mugs-of-the-bugs-the-most-wanted-ones
#11
Richard A Stein
No abstract text is available yet for this article.
June 15, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28594475/what-is-safety-miracles-benefit-risk-assessments-and-the-right-to-try
#12
Lisa M DeTora
Public discourse is full of quick solutions to health care problems like cancer and rare diseases. Among these is Right to Try legislation for experimental therapies. Right to Try legislation is based on the premise that all experimental agents in clinical trials are safe and guaranteed to produce miracles. Unfortunately, this notion is at odds with expert understanding, which indicates that the benefits and risks of drug products can only be understood together and evaluated incrementally and over time. The current manuscript examines why benefit to risk considerations, a lynchpin of the ethical conduct of clinical research since the Nuremberg Code, might be easily elided from public discourse...
June 8, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28594462/determinants-of-sexual-function-and-dysfunction-in-men-and-women-with-stroke-a-systematic-review
#13
REVIEW
Wendy Dusenbury, Pernille Palm Johansen, Victoria Mosack, Elaine E Steinke
AIM: The aim of this systematic review was to examine determinants of sexual function and dysfunction in men and women poststroke, and to evaluate effectiveness of interventions. METHODS: A systematic review was conducted using the databases of PubMed, Medline, CINAHL, Cochrane, and Psychinfo, for studies published between January, 2000 and October, 2016. Included were original research, adult ≥18 years, English language, and experimental and non-experimental designs...
June 8, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28594459/computer-vision-syndrome-a-common-cause-of-unexplained-visual-symptoms-in-the-modern-era
#14
REVIEW
Sunil Munshi, Ashley Varghese, Sushma Dhar-Munshi
OBJECTIVES: The aim of this study was to assess the evidence and available literature on the clinical, pathogenetic, prognostic and therapeutic aspects of Computer vision syndrome. METHODS: Information was collected from Medline, Embase & National Library of Medicine over the last 30 years up to March 2016. The bibliographies of relevant articles were searched for additional references. FINDINGS: Patients with Computer vision syndrome present to a variety of different specialists, including General Practitioners, Neurologists, Stroke physicians and Ophthalmologists...
June 8, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28544106/inappropriate-prescribing-in-chronic-kidney-disease-a-systematic-review-of-prevalence-associated-clinical-outcomes-and-impact-of-interventions
#15
REVIEW
Wubshet Hailu Tesfaye, Ronald L Castelino, Barbara C Wimmer, Syed Tabish R Zaidi
INTRODUCTION: Adjusting doses of renally cleared medications and/or avoidance of nephrotoxic medications are standard clinical practices in chronic kidney disease (CKD), albeit the prevalence of inappropriate prescribing (IP) in these patients remains high. Therefore, this work sought to systematically review the prevalence of IP and compare the relative effectiveness of available interventions in reducing IP in CKD. METHODS: Studies were identified searching PubMed/Medline, EMBASE, Cochrane Library, IPA, Web of Science, Ovid/Medline, CINAHL, and PsychINFO databases...
May 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28544081/direct-medical-costs-of-severe-hypoglycaemic-events-in-patients-with-type-2-diabetes-in-england-a-retrospective-database-study
#16
Tim Holbrook, Yuexin Tang, Romita Das, R Ravi Shankar, Kaan Tunceli, Jean Williams, Larry Radican, Sarah E Holden, Chris Ll Morgan, James Piercy, Craig J Currie
AIMS: Hypoglycaemia in patients with diabetes can be induced by insulins and sulfonylureas. We assessed the real-world impact of specific monotherapy and combination regimens on hypoglycaemic events requiring hospitalisation and related secondary costs to the English healthcare system. METHODS: This retrospective observational study used the Clinical Practice Research Datalink with linked hospital admission data during 2008-2012. Patients with type 2 diabetes mellitus (T2DM) using antihyperglycaemic agents (AHAs) were assigned to mutually exclusive subgroups (insulin- and non-insulin-containing regimens; treatment groups of interest; age group) based on treatment at index date (date of first AHA prescription)...
May 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28741813/peripheral-arterial-disease-amongst-british-ethnic-minorities-in-a-community-based-population-the-ethnic-echocardiographic-heart-of-england-screening-study-e-echoes
#17
LETTER
Antonios Vitalis, Alena Shantsila, Rajiv K Vohra, Mark Kay, Philip C Bennett, Gregory Y H Lip, Paramjit S Gill
No abstract text is available yet for this article.
July 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28741812/impact-of-binge-eating-disorder-on-functional-impairment-and-work-productivity-in-an-adult-community-sample-in-the-united-states
#18
Manjiri Pawaskar, Edward A Witt, Dylan Supina, Barry K Herman, Thomas A Wadden
AIM: This study compared functioning and productivity in individuals meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for binge eating disorder (BED) to those without BED. METHODS: A sample of US adults from the National Health and Wellness Survey completed an Internet survey in October 2013. In addition to BED diagnostic criteria, the survey assessed functional impairment and productivity, respectively, using the Sheehan Disability Scale (SDS) and Work Productivity and Activity Impairment (WPAI) questionnaire...
July 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28741811/authorship-musings-about-guests-and-ghosts
#19
EDITORIAL
Leslie Citrome
No abstract text is available yet for this article.
July 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28613453/the-scourge-of-uromycitisis-and-fake-journals
#20
EDITORIAL
Leslie Citrome
No abstract text is available yet for this article.
June 2017: International Journal of Clinical Practice
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