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International Journal of Clinical Practice

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https://www.readbyqxmd.com/read/28449320/a-randomised-double-blind-trial-of-the-safety-and-efficacy-of-omarigliptin-a-once-weekly-dpp-4-inhibitor-in-subjects-with-type-2-diabetes-and-renal-impairment
#1
Antonio Chacra, Ira Gantz, Geraldine Mendizabal, Lucila Durlach, Edward A O'Neill, Zachary Zimmer, Shailaja Suryawanshi, Samuel S Engel, Eseng Lai
AIMS: To assess the safety and efficacy of omarigliptin in subjects with type 2 diabetes mellitus (T2DM) and chronic renal impairment (RI). METHODS: Patients with T2DM with moderate RI (estimated glomerular filtration rate [eGFR] ≥30 to <60 mL/min/1.73 m(2) ) (N=114), severe RI (eGFR <30 mL/min/1.73 m(2) ) (N=55) or end-stage renal disease on dialysis (N=44), who were either not on an antihyperglycaemic agent therapy for at least 12 weeks at screening, washed-off of oral antihyperglycaemic agent monotherapy or low-dose dual combination therapy, or on insulin monotherapy, with baseline glycated haemoglobin (HbA1c) of 6...
April 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28440009/sodium-glucose-co-transporter-2-inhibitors-for-type-2-diabetes-mellitus-an-overview-for-the-primary-care-physician
#2
REVIEW
Paresh Dandona, Ajay Chaudhuri
AIMS: Sodium-glucose co-transporter type 2 (SGLT2) inhibitors are a new class of anti-hyperglycaemic agents in type 2 diabetes mellitus (T2DM). This review examines their mechanism of action and provides an overview of safety and efficacy from the main studies of SGLT2 inhibitors marketed in the United States and Europe, namely, canagliflozin, dapagliflozin and empagliflozin. METHODS: We searched the PubMed database to identify relevant publications on the mechanism of action of SGLT2 inhibitors and clinical trial reports...
April 24, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28439994/ethnicity-and-age-as-factors-in-sildenafil-treatment-of-erectile-dysfunction
#3
Dana A Ohl, Vera Stecher, Li-Jung Tseng
INTRODUCTION: Sildenafil has been evaluated in >16 000 men with erectile dysfunction (ED) in double-blind, placebo-controlled trials. AIM: To assess efficacy and safety of sildenafil in ED by ethnicity (white, black Asian) and age (≤45, 46-60, ≥61 years). METHODS: Data were pooled from 38 double-blind, placebo-controlled, flexible-dose trials. Most had starting sildenafil doses of 50 mg once daily, ~1 hour before sexual activity, with adjustment to 100 or 25 mg as needed...
April 24, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28419650/cardiovascular-safety-in-refractory-incontinent-patients-with-overactive-bladder-receiving-add-on-mirabegron-therapy-to-solifenacin-beside
#4
Marcus J Drake, Scott MacDiarmid, Christopher R Chapple, Adil Esen, Stavros Athanasiou, Javier Cambronero Santos, David Mitcheson, Sender Herschorn, Emad Siddiqui, Moses Huang, Matthias Stoelzel
AIMS/OBJECTIVES: In the BESIDE study, combination therapy (antimuscarinic [solifenacin] and β3 -adrenoceptor agonist [mirabegron]) improved efficacy over solifenacin monotherapy without exacerbating anticholinergic side effects in overactive bladder (OAB) patients; however, a potential synergistic effect on the cardiovascular (CV) system requires investigation. METHODS: OAB patients remaining incontinent despite daily solifenacin 5 mg during 4-week single-blind run-in, were randomised 1:1:1 to double-blind daily combination (solifenacin 5 mg/mirabegron 25 mg, increasing to 50 mg after week 4), solifenacin 5 or 10 mg for 12 weeks...
April 16, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28382763/appraising-the-quality-of-clinical-practice-guidelines-in-traditional-chinese-medicine-using-agree-ii-instrument-a-systematic-review
#5
REVIEW
Liang Yao, Yaolong Chen, Xiaoqin Wang, Xiue Shi, Yongfen Wang, Tiankang Guo, Kehu Yang
OBJECTIVES: The aim of this study was to investigate the quality of clinical practice guidelines (CPGs) of traditional Chinese medicine (TCM) published in journals and books using AGREE II instrument for further enhancing TCM CPG development. METHODS: A systematic search of relevant guideline websites and literature databases (including Chinese Guideline Clearinghouse, PubMed Wanfang Data Knowledge Service Platform, VIP Online Publishing Platform, China National Knowledge Infrastructure and SinoMed) was undertaken from inception to December, 2015 to identify and select CPGs related to TCM...
April 5, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371025/treatment-response-to-sildenafil-in-men-with-erectile-dysfunction-relative-to-concomitant-comorbidities-and-age
#6
Irwin Goldstein, Vera Stecher, Martin Carlsson
AIM: To evaluate treatment response in men with erectile dysfunction (ED) and concomitant comorbidities. METHODS: Data were pooled from 42 placebo-controlled, flexible-dose sildenafil trials. In most trials, the sildenafil dose was 50 mg, taken ~1 hour before sexual activity but not more than once daily, with adjustment to 100 or 25 mg as needed. The overall population (N=9413) was stratified by age (<45, 46-64, ≥65 years). Treatment response was defined as a minimal clinically important difference (MCID) from baseline in the International Index of Erectile Function-Erectile Function (IIEF-EF) domain score of >2, >5 and >7 for men with mild, moderate and severe ED at baseline, respectively, or an IIEF-EF domain score ≥26 (no ED) at end-point...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371024/discharge-disposition-as-an-independent-predictor-of-readmission-among-patients-hospitalised-for-community-acquired-pneumonia
#7
Tien Dong, John F Cursio, Samira Qadir, Peter K Lindenauer, Gregory W Ruhnke
BACKGROUND: Community-acquired pneumonia (CAP) is the most common non-obstetrical reason for hospital admission, the leading infectious cause of death, and a target for public reporting. CAP has thus become a target of quality improvement and pay-for-performance efforts. However, the relationship between discharge disposition and readmission risk has not been investigated. METHODS: We studied CAP patients admitted to the University of Chicago from 11/2011 to 04/2015...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371023/sensible-economies-demand-management-in-blood-science-laboratories
#8
EDITORIAL
Anthony S Wierzbicki
No abstract text is available yet for this article.
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371022/sociodemographic-factors-are-associated-with-utilisation-of-statins-after-ischaemic-stroke-tia
#9
Lukas Geary, Jonas Aronius, Björn Wettermark, Jan Hasselström, Bengt Sjöborg, Mia von Euler
OBJECTIVES: To analyse if there are sociodemographic differences in the utilisation of statins 9-12 months after ischaemic stroke or transitory ischaemic attack. METHODS: Anonymised linkage of registry data on all patients >18 years discharged from the hospitals in Stockholm, Sweden 2006-2010 with diagnosis of ischaemic stroke (ICD-10: I63.0-9) or TIA (ICD-10: G45.9) was performed. Data on hospitalisations and diagnoses were collected from the Stockholm County Council administrative databases on healthcare consumption...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371021/hypoglycaemia-in-the-over-75s-understanding-the-predisposing-factors-in-type-2-diabetes-t2dm
#10
LETTER
Adrian H Heald, Simon G Anderson, Videlina Cholakova, Marco Narajos, Adnan Khan, Gemma Donnahey, Mark Livingston
No abstract text is available yet for this article.
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371020/virtually-yours-curated-collections-of-articles
#11
EDITORIAL
Leslie Citrome
No abstract text is available yet for this article.
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371019/adherence-and-persistence-of-mirabegron-and-anticholinergic-therapies-in-patients-with-overactive-bladder-a-real-world-claims-data-analysis
#12
D Sussman, A Yehoshua, J Kowalski, W Lee, J Kish, S Chaudhari, B Murray
BACKGROUND: Adherence and persistence rates of anticholinergic (ACH) therapies have been well described. To date, few studies describe these metrics for mirabegron in patients with overactive bladder. METHODS: This retrospective analysis of MarketScan(®) database assessed adherence and persistence of patients receiving either mirabegron or ACH. Study eligibility required an index date (first prescription filled) between July 2012 and June 2013 with 12 months of continuous enrolment preindex date and 12 months of follow-up...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28371018/clinical-appropriateness-of-c-reactive-protein-requests-reduction-in-unnecessary-repeats
#13
LETTER
Mark Livingston, Anura Kalansooriya, Adrian H Heald
No abstract text is available yet for this article.
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28318076/uk-policy-statements-on-testosterone-deficiency
#14
Geoffrey Hackett, Michael Kirby, David Edwards, T Hugh Jones, Jonathan Rees, Asif Muneer
To address widespread media and scientific concerns over the appropriate treatment of TDS with Testosterone Therapy (T Therapy), the Executive Committee of the British Society for Sexual Medicine developed eight consensus statements, based on current scientific evidence to address these controversial issues. These statements were in no-way designed to replace the published evidence-based guidelines on the subject developed by various professional organisations, but to provide specific answers to several current controversial issues...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28276182/application-of-the-national-early-warning-score-news-as-a-stratification-tool-on-admission-in-an-italian-acute-medical-ward-a-perspective-study
#15
Walter Spagnolli, Marta Rigoni, Emanuele Torri, Susanna Cozzio, Elisa Vettorato, Giandomenico Nollo
AIM: We aimed to assess the performance of the National Early Warning Score (NEWS) as tool for patient risk stratification at admission in an acute Internal Medicine ward and to ensure patient placement in ward areas with the required and most appropriate intensity of care. As secondary objective, we considered NEWS performance in two subgroups of patients: sudden cardiac events (acute coronary syndromes and arrhythmic events), and chronic respiratory insufficiency. METHODS: We conducted a perspective cohort single centre study on 2,677 unselected patients consecutively admitted from July 2013 to March 2015 in the Internal Medicine ward of the hospital of Trento, Italy...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28150372/coexistent-malignant-conditions-in-rheumatoid-arthritis-a-population-based-cross-sectional-study
#16
Amir Dagan, Gad Segal, Shmuel Tiosano, Abdulla Watad, Shana G Neumann, Doron Comaneshter, Arnon D Cohen, Howard Amital
OBJECTIVES: The aim of this study was to evaluate if association exist between rheumatoid arthritis and malignant diseases. METHODS: A cross-sectional study was conducted comparing rheumatoid arthritis patients with age and gender matched controls regarding the proportion of patients with comorbid malignant conditions. Chi-square tests and t-tests were used for univariate analysis. A logistic regression model was used for multivariate analysis. The study was performed utilising the medical database of Clalit Health Services...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238231/what-to-watch-in-medicine-in-2017-hot-topics
#17
EDITORIAL
Leslie Citrome
No abstract text is available yet for this article.
February 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238230/corrigendum
#18
(no author information available yet)
No abstract text is available yet for this article.
February 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238229/suspecting-non-cystic-fibrosis-bronchiectasis-what-the-busy-primary-care-clinician-needs-to-know
#19
REVIEW
Diego J Maselli, Bravein Amalakuhan, Holly Keyt, Alejandro A Diaz
AIMS: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. In the last several decades, its prevalence has increased, making it likely to be encountered in the primary care setting. The aim was to review the clinical presentation and diagnosis of NCFB, with an emphasis on the role of computed tomography (CT)...
February 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238228/is-sedentary-behaviour-unhealthy-and-if-so-does-reducing-it-improve-this
#20
REVIEW
Shao-Hua Chin, Chanaka Kahathuduwa, Martin Binks
PURPOSE: To provide a qualitative synthesis of the available literature on the role of sedentary behavior in health. AIMS: We sought to determine if (i) being sedentary 'causes' health problems and (ii) interventions to reduce sedentary behavior improve health status. METHODS: PubMed and Google Scholar databases were utilized. Manuscripts published from 2001 to 2015 using specific keyword combinations (eg sedentary behavior, physical activity, sitting, intervention) were included and qualitatively reviewed...
February 2017: International Journal of Clinical Practice
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