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International Journal of Clinical Practice

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https://www.readbyqxmd.com/read/29767479/nocturia-is-more-bothersome-than-daytime-luts-results-from-an-observational-real-life-practice-database-including-8659-european-and-american-luts-patients
#1
Karel Everaert, Peter Anderson, Robert Wood, Fredrik L Andersson, Tove Holm-Larsen
PURPOSE: Lower urinary tract symptoms (LUTS) encompass several diagnoses, including overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Nocturia is a standalone symptom, but also included in OAB and BPH. Current discussion addresses whether the overlap of the diagnoses is too broad, leading to misdiagnosis. This study explored the differences in level, causes and consequences for patients with a diagnosis of daytime LUTS compared with a diagnosis of nocturia, and discussed whether people are being treated for the symptoms that truly bother them the most...
May 16, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29767472/the-impact-of-real-world-cardiovascular-related-pharmacogenetic-testing-in-an-insured-population
#2
Jennifer Billings, Patrick N Racsa, Kristine Bordenave, Charron L Long, Jeffrey J Ellis
BACKGROUND: Pharmacogenomics is intended to help clinicians provide the right drug to the right patient at an appropriate dose. However, limited evidence of clinical utility has slowed uptake of pharmacogenomic testing (PGT). OBJECTIVE: To evaluate the impact of real-world cardiovascular (CV)-related PGT on clinical outcomes, healthcare resource utilisation (HCRU) and cost in a large, heterogeneous population. METHODS: Individuals with Medicare Advantage Prescription Drug, Medicaid, or commercial coverage between 1/1/2011 and 9/30/2015 and ≥1 atherosclerotic CV-related diagnosis were identified...
May 16, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29732687/patient-centred-medical-home-pcmh-and-patient-practitioner-orientation-is-there-a-relationship
#3
Shamima Khan, Harlan E Spotts, Peter C Lindblad, Joshua J Spooner
BACKGROUND: The patient-centred medical home (PCMH) and utilisation of a patient-centred care approach have been promoted as opportunities to improve healthcare quality while controlling expenditures. OBJECTIVES: To determine the penetration of PCMH within physician practices, and to evaluate physician attitudes towards patient-practitioner orientation. The ultimate objective was to explore relationships between the patient-practitioner orientation of respondents and the presence of PCMH elements within their practice...
May 6, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29726067/readability-of-endoscopy-information-leaflets-implications-for-informed-consent
#4
Matthew C Mason, James M L Williamson
INTRODUCTION: Valid consent for gastrointestinal endoscopy is required for ethical and legal reasons. Patients are frequently met by an endoscopist for the first time on the day of their procedure. For valid consent to be possible, the patient needs to have received and understood generic information regarding endoscopy in advance. Patient information leaflets (PILs) need to be easily understood by the majority of the population. METHOD: PILs from 14 secondary care institutions and a sample PIL from the British Society of Gastroenterology were analysed using an online readability tool...
May 3, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29707876/maintenance-dose-conversion-between-oral-risperidone-and-paliperidone-palmitate-1-month-practical-guidance-based-on-pharmacokinetic-simulations
#5
Alberto Russu, Jennifer Kern Sliwa, Paulien Ravenstijn, Arun Singh, Maju Mathews, Edward Kim, Srihari Gopal
AIM: We assessed the dosage strengths of paliperidone palmitate 1-month (PP1M) long-acting injectable resulting in similar steady-state (SS) exposures to the dosage strengths of oral risperidone using pharmacokinetic (PK) simulations. METHODS: Population PK simulations of SS PK were performed using the PK models of oral risperidone and PP1M. The concentrations of active moiety (risperidone + paliperidone) from risperidone were compared to paliperidone concentrations resulting from PP1M administration...
April 30, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691971/hydroxychloroquine-may-be-associated-with-reduced-risk-of-coronary-artery-diseases-in-patients-with-rheumatoid-arthritis-a-nationwide-population-based-cohort-study
#6
Yao-Min Hung, Yu-Hsun Wang, Lichi Lin, Paul Yung Pou Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
OBJECTIVES: The aim of this study was to determine whether hydroxychloroquine (HCQ) usage is associated with incidental risk of coronary artery diseases (CAD) in patients with rheumatoid arthritis (RA). METHODS: The Longitudinal Health Insurance Database in Taiwan was used. The study cohort comprised of 1104 newly diagnosed RA patients between 2001-2010, and patients were followed until 31 December 2011. Patients with history of CAD before RA diagnosis were excluded...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691962/gastrointestinal-symptoms-in-children-primary-care-and-specialist-interface
#7
REVIEW
Valeria Dipasquale, Domenico Corica, Simone M C Gramaglia, Simona Valenti, Claudio Romano
AIMS: Gastrointestinal symptoms and diseases represent one of the major reasons for paediatricians' requests for specialist consultations and hospital admissions. One fourth of annual medical consultations for children younger than 6 years can be attributed to gastrointestinal symptoms. High-quality guidelines have been validated worldwide to provide clinical recommendations and support healthcare providers' practice. Nevertheless, overall compliance to standards of care is unsatisfactory, and children with gastrointestinal symptoms frequently undergo expensive, useless specialist consultations and laboratory evaluations...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691957/very-long-term-outcome-of-schizophrenia
#8
REVIEW
Jan Volavka, Jan Vevera
PURPOSE: The principal aim is to review recent data concerning the very long-term outcome of schizophrenia and schizophrenia spectrum disorders. We examine factors that influence outcome, including therapeutic interventions. METHOD: PubMed and Scopus databases were searched for papers published between 2008 and 2017 reporting on prospective studies of schizophrenia or schizophrenia spectrum with a follow-up period ≥5 years with adequate outcome information. Additional publications were found in reference lists and authors' reference libraries...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29683237/establishing-a-proactive-geriatrician-led-comprehensive-geriatric-assessment-in-older-emergency-surgery-patients-outcomes-of-a-pilot-study
#9
Matthew C Mason, Amy L Crees, Matthew R Dean, Nahida Bashir
INTRODUCTION: Increasing numbers of older adults are presenting with acute surgical disease to the unselected general surgical take. General surgeons have little training to manage these patients. We developed a pilot service of proactive geriatrician input into older emergency general surgical patients in a single institution. We wanted to demonstrate if geriatricians improve the management of these patients. METHODS: Patients aged 70 years or older admitted acutely under the general surgeons were assessed proactively by a geriatrician using comprehensive geriatric assessment (CGA)...
April 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29672991/glycaemic-optimization-for-patients-with-cardiac-disease-a-before-and-after-study
#10
Tripti Joshi, Sarah-Jane Pullen, Alison Gebuehr, Christopher Oldmeadow, John Richard Attia, Shamasunder Halady Acharya
AIM: To investigate if glycaemic profiles and outcomes of patients with diabetes admitted for cardiothoracic surgery or acute coronary syndrome improved after implementation of a structured glycaemia management guideline. METHODS: This is a retrospective before-and-after comparative analysis of outcomes for all consecutive cardiothoracic and acute coronary syndrome patients with diabetes (N = 375), who were admitted at our tertiary-care university-affiliated hospital during the preguideline period (July-December, 2013) and the postguideline period (July-December, 2014)...
April 19, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29665222/first-keep-it-safe-integration-of-a-complementary-medicine-service-within-a-hospital
#11
Elad Schiff, Ilana Levy, Zahi Arnon, Eran Ben-Arye, Samuel Attias
OBJECTIVES: This paper sought to explore risk/safety considerations associated with the integration of a complementary medicine (CM) service within a public academic medical centre in Israel. METHODS: We reviewed various sources pertaining to the CM service (interviews with CM staff, patients' electronic charts, service guidelines, correspondence with hospital administration) and conducted a thematic analysis to evaluate safety-related incidents during the 7 years of operation...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29665199/authorship-in-reports-of-clinical-practice-guidelines-a-systematic-cross-sectional-analysis
#12
Mohamed Nomier, Assem M Khamis, Ahmed Ali, Karim N Daou, Aline T Semaan, Maya Diab, Elie A Akl
BACKGROUND: A transparent and explicit reporting on authors' contributions to the development of clinical practice guidelines and on panelists' characteristics is essential for their credibility and trustworthiness. We did not find published studies on authorship or panel involvement in clinical practice guidelines. OBJECTIVE: To describe the approach to authorship in reports of clinical practice guidelines, and the characteristics of individual authors. METHODS: We conducted a cross-sectional survey of guidelines listed in the National Guideline Clearing House (NGC) in 2016...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29665161/poverty-as-an-independent-risk-factor-for-in-hospital-mortality-in-community-acquired-pneumonia-a-study-in-a-developing-country-population
#13
Hassan Jahanihashemi, Mona Babaie, Soroush Bijani, Maryam Bazzazan, Behzad Bijani
BACKGROUND: Community-acquired pneumonia (CAP) is one of the most severe lower respiratory tract infections with a high in-hospital mortality. The aim of this study was to investigate the socioeconomic and medical risk factors affecting the prognosis of acute pneumonia. The results of this study can mention the value of socioeconomic backgrounds like poverty and illiteracy in clinical practice, even in a well-known biological phenomenon (eg acute pneumonia). METHODS: In this cross-sectional study, all admitted patients to a tertiary teaching hospital with a diagnosis of community acquired pneumonia in a 12-month period were enrolled...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29665154/development-and-validation-of-a-risk-stratification-score-for-new-onset-atrial-fibrillation-in-stemi-patients-undergoing-primary-percutaneous-coronary-intervention
#14
Annamaria Mazzone, Marco Scalese, Umberto Paradossi, Serena Del Turco, Nicoletta Botto, Alberto De Caterina, Giuseppe Trianni, Marcello Ravani, Antonio Rizza, Sabrina Molinaro, Cataldo Palmieri, Sergio Berti, Giuseppina Basta
AIM: New-onset atrial fibrillation (NOAF) is a complication not infrequent in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and has been associated with worse in-hospital and long-term prognosis. We aimed to develop and validate a risk score based on common clinical risk factors and routine blood biomarkers to assess the early incidence of NOAF post-pPCI, before discharge. METHODS: The risk score for NOAF occurrence during hospitalisation (about 5 days) was developed in a cohort of 1135 consecutive STEMI patients undergoing pPCI while was externally validated in a temporal cohort of 771 STEMI patients...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29569323/real-world-observational-results-from-a-database-of-48-million-men-in-the-united-states-relationship-of-cardiovascular-disease-diabetes-mellitus-and-depression-with-age-and-erectile-dysfunction
#15
Irwin Goldstein, Richard Chambers, WingYu Tang, Vera Stecher, Tarek Hassan
AIMS: To evaluate the relationship of comorbidities (cardiovascular disease [CVD], diabetes mellitus [DM] and depression) with erectile dysfunction (ED) and age using real-world claims data from 48 million men in the United States. METHODS: This was a cross-sectional, non-interventional study in men aged ≥18 years using data from the Truven Health MarketScan® and Medicare Supplemental Research Databases from January 2010 to December 2015, with an observational period of January 2011 to December 2014 to allow for 12 months pre- and post-index...
March 22, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29537664/the-pattern-of-prescribing-of-glucose-modulating-agents-for-type-2-diabetes-in-general-practices-in-england-2016-17
#16
Adrian H Heald, Mark Livingston, Zuzanna Bien, Gabriela Y C Moreno, Ian Laing, Mike Stedman
BACKGROUND: In the financial year 2016/17 there were 52.0 million items prescribed for diabetes at a total net ingredient cost of £983.7 million - up from 28.9 million prescription items and £572.4 million in 2006/07. Anti-diabetes drugs (British National Formulary section 6.1.2) make up 45.1 per cent of the total £983.7 million net ingredient cost of drugs used in diabetes and account for 72.0 per cent of prescription items for all diabetes prescribing. METHODS: We examined the way that agents licensed to treat type 2 diabetes were used across GP practices in England in the year 2016/2017...
March 14, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29532980/the-effect-of-splenectomy-on-the-levels-of-pcv-13-induced-memory-b-and-t-cells
#17
Umut Gazi, Djursun Karasartova, Ibrahim Tayfun Sahiner, Ayse Semra Gureser, Ozgur Tosun, Mehmet Kursat Derici, Mete Dolapci, Aysegul Taylan Ozkan
AIM: Splenectomised patients are associated with lifelong risk of fatal overwhelming post-splenectomy infection (OPSI), which is mostly caused by Streptococcus pneumoniae. Today OPSI cases can still be reported even in patients with appropriate vaccination. In our study, the levels of vaccine-specific memory B- and T cells were compared between control and splenectomised patients to enlighten the underlying reason. MATERIALS AND METHODS: Five healthy and 14 post-traumatic splenectomised individuals were vaccinated with 13-valent pneumococcal conjugate vaccine (PCV-13) followed by 23-valent pneumococcal polysaccharide vaccine (PPV-23)...
March 13, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29512239/the-changing-vista-of-pleural-effusion-management-indwelling-pleural-catheters-ipc
#18
Sarah Jane Messeder, Mahendran Chetty, Megan C Thomson, Graeme P Currie
No abstract text is available yet for this article.
March 7, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29493846/clinically-important-difference-on-the-erectile-dysfunction-inventory-of-treatment-satisfaction-questionnaire-in-patients-with-erectile-dysfunction
#19
Joseph C Cappelleri, Li-Jung Tseng, Vera J Stecher, Stanley E Althof
AIM: To determine what constitutes a clinically important difference (CID) on the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), an 11-item validated questionnaire assessing treatment satisfaction used in clinical trials for patients with erectile dysfunction (ED). METHODS: Erectile Dysfunction Inventory of Treatment Satisfaction data were evaluated from a double-blind, fixed-dose trial of 279 men aged 18-65 years with ED who were treated with sildenafil 50 or 100 mg or placebo...
March 1, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29667776/disclosures-full-transparency-is-required
#20
EDITORIAL
Leslie Citrome
No abstract text is available yet for this article.
March 2018: International Journal of Clinical Practice
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