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International Journal of Clinical Practice. Supplement

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https://www.readbyqxmd.com/read/26177348/comparison-of-tacrolimus-and-cyclosporin-a-in-cyp3a5-expressing-chinese-de-novo-kidney-transplant-recipients-a-2-year-prospective-study
#1
L-S Liu, J Li, X-T Chen, H-X Zhang, Q Fu, H-Y Wang, Y-Y Xiong, S Liu, X-M Liu, J-L Li, M Huang, C-X Wang
AIMS: To assess the efficacy and safety of tacrolimus and cyclosporin A (CsA)-based immunosuppressive regimens in Chinese de novo kidney transplant recipients who are CYP3A5 expressers. METHODS: The CYP3A5 (6986 A>G, rs776746) polymorphism of eligible patients was determined before transplantation. De novo kidney transplant recipients enrolled in this study were assigned to tacrolimus (Tac group) or CsA (CsA group) based therapy. The follow-up period was 2 years...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26177265/efficacy-and-safety-of-basiliximab-in-liver-transplantation-for-patients-with-hepatitis-b-virus-related-diseases-a-single-centre-study
#2
M Xiao, X Xu, H Zhu, R Zhuang, P Xiang, T Wang, L Zhuang, Q Wei, X Wei, L Zhang, J Wu, S Zheng
AIMS: We aim to evaluate the efficacy and safety of basiliximab in liver transplantation (LT) for patients with hepatitis B virus-related diseases. METHODS: A total of 268 patients with hepatitis B virus-related diseases undergoing LT were enrolled and divided into two groups according to the usage of basiliximab. Total survival, the survival of high-risk patients defined by the posttransplant model for predicting mortality, acute rejection rate, biochemical parameters and other follow-up data were compared between the two groups...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26177162/human-parvovirus-b19-infection-induced-pure-red-cell-aplasia-in-liver-transplant-recipients
#3
M Zhang, X Zhong, W Zhang, J Xu, M Zhang, Y Shen, W Wang, S Zheng
AIM: Th aim of this study was to explore the diagnosis and treatment of pure red cell aplasia (PRCA) induced by human parvovirus B19 (HPV B19) infection in liver transplant recipients. METHODS: We described and analysed the clinical manifestation, diagnosis, treatment and prognosis of the 13 liver transplant recipients confirmed to have PRCA induced by HPV B19. RESULTS: In the past 3 years, 13 liver transplant recipients out of a cohort of 570 recipients were confirmed to have PRCA induced by HPV B19...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26177071/interleukin-2-receptor-antagonist-compared-with-antithymocyte-globulin-induction-therapy-in-kidney-transplantation-from-donors-after-cardiac-death
#4
W Peng, G Liu, W Xie, H Huang, J Wu, Z Shou, J Chen
AIMS: The aim of this study was to compare the efficacy and safety of induction therapy using the interleukin-2 receptor antagonist (IL-2RA) with antithymocyte globulin (ATG) under a tacrolimus-based immunosuppression regimen in kidney transplantation from donors after cardiac death. METHODS: It was a single-centre, retrospective, cohort study design to evaluate the efficacy and safety of IL-2RA vs. ATG induction therapy in adult renal transplant recipients from donors after cardiac death...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26177012/effect-of-cyp3a5-polymorphism-on-the-pharmacokinetics-of-tacrolimus-and-acute-rejection-in-renal-transplant-recipients-experience-at-a-single-centre
#5
Y Cheng, H Li, Y Meng, H Liu, L Yang, T Xu, J Yu, N Zhao, Y Liu
AIM: As a substrate of cytochrome P450 (CYP) 3A5, tacrolimus is characterised by a narrow therapeutic index and large inter-individual variability. Our objective was to determine the influence of CYP3A5 genetic polymorphisms on tacrolimus pharmacokinetics and acute rejection in Chinese renal transplant recipients. METHODS: Thirty-five renal recipients treated with tacrolimus in our centre were genotyped for CYP3A5 single nucleotide polymorphisms, CYP3A5*1 (6986A) and CYP3A5*3 (6986G)...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26176940/outcomes-of-standard-dose-ec-mps-with-low-exposure-to-csa-in-dcd-renal-transplantation-recipients-with-dgf
#6
C Ding, W Xue, P Tian, X Ding, X Pan, H Yan, H Xiang, X Feng, J Hou, X Tian, Y Li, J Zheng
AIMS: The lower limit of exposure to cyclosporine A (CsA) has not yet been established in donation after cardiac death (DCD) renal transplantation recipients with delayed graft function (DGF) receiving enteric-coated mycophenolate sodium (EC-MPS) therapy. Stable and adequate mycophenolic acid (MPA) dosing may facilitate lower CsA exposure after DCD renal transplantation in recipients with DGF without compromising safety. METHODS: A 12-month, single-centre open-label prospective trial was performed in our centre...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26176848/enteric-coated-mycophenolate-sodium-given-in-combination-with-tacrolimus-has-a-lower-incidence-of-serious-infections-in-asian-renal-transplant-recipients-compared-with-mycophenolate-mofetil
#7
J J Feng, L W Zhang, P Zhao, L M Bow, J Tian
AIMS: To compare the characteristics of the enteric-coated formulation of mycophenolate sodium (EC-MPS, myfortic) and mycophenolate mofetil (MMF, CellCept) given in combination with tacrolimus in Asian renal-transplant recipients. METHODS: In a 24-month, single-centre, randomized, open-label, prospective study, 101 live-donor kidney transplant recipients were randomized to the EC-MPS (n = 50) or MMF (n = 51) group. The incidence of infection, therapeutic effect and adverse events were monitored...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/26176181/influence-of-cyp3a5-genotypes-on-tacrolimus-dose-requirement-age-and-its-pharmacological-interaction-with-abcb1-genetics-in-the-chinese-paediatric-liver-transplantation
#8
T-H Yang, Y-K Chen, F Xue, L-Z Han, C-H Shen, T Zhou, Y Luo, J-J Zhang, Q Xia
AIM: The purpose of the study was to evaluate the impact of single nucleotide polymorphisms (SNPs) of Cytochrome P450 (CYP) 3A5 and adenosine triphosphate-binding cassette B1 (ABCB1) genotypes on TAC pharmacokinetics in Chinese paediatric patients. METHOD: A total of 136 Chinese paediatric liver recipients (R) and their donors (D) were divided into groups according to their CYP3A5 genotypes [expression of *1 allele: expressor (EX) or non-expressor (NEX)]. RESULT: Both recipient and donor CYP3A5*1 alleles had impacts on the TAC pharmacokinetics after liver transplantation...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907022/changing-behaviours-interventions-that-count
#9
REVIEW
M J Forshaw
Many individuals affected by tension-type headache (TTH) choose the self-care route without seeking medical advice from their primary care doctor. As a result, community pharmacies play an important role in identifying patients with TTH, providing education and counselling on potential lifestyle trigger factors and recommending appropriate analgesics.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907021/analgesic-safety-myths-mysteries-and-misconceptions
#10
REVIEW
R A Moore
Acute episodes of tension-type headache (TTH) are common and affect people of all ages, races and income levels. Two recommended and commonly used drugs for the treatment of this condition are ibuprofen and paracetamol. However, despite - or perhaps because of - their widespread use, many misconceptions persist about their comparative efficacy and safety. Are concerns about the gastrointenstinal (GI) safety of ibuprofen justified in the non-prescription over-the-counter (OTC) setting? Do low doses of ibuprofen - as used for TTH - increase the risk of heart attacks? Is the efficacy of ibuprofen and paracetamol really the same?...
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907020/speed-science-and-optimal-pain-relief
#11
REVIEW
R A Moore
Pain is a major global health problem. Six of the 11 most prevalent conditions worldwide are pain-related, with tension-type headache and migraine being the second and third most prevalent conditions. Pain also ranks high among the conditions that have the longest-lasting impact: five of the top 11 contributors to years lived with disability are pain-related.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907019/community-based-headache-management
#12
REVIEW
T Maguire
Tension-type headache (TTH) - also known as 'regular' or 'ordinary' headache - is extremely common. The key symptom is a tight band or pressing pain felt on both sides of the head. The headache pain in TTH is mild or moderate and lasts from several hours up to a few days. TTH usually responds well to treatment with simple over-the-counter (OTC) analgesics such as ibuprofen and paracetamol.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907018/treatment-guidelines-implications-for-community-based-headache-treatment
#13
REVIEW
L Bendtsen
Tension-type headache (TTH) is the most common form of headache in the community, affecting up to 80% of people from time to time. At least 10% of people experience episodic TTH on a frequent basis (up to 14 days per month) and the condition is chronic for 2- 3%.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907017/headache-muscle-tension-trigger-points-and-referred-pain
#14
REVIEW
L Arendt-Nielsen
Scientific interest in the pathogenesis of tension-type headache (TTH) has lagged behind that of migraine, although TTH is the most common headache disorder and considered the most important in terms of socioeconomic impact. As a result, understanding of the underlying mechanisms of TTH has remained relatively incomplete.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907016/the-burden-of-headache-global-and-regional-prevalence-of-headache-and-its-impact
#15
REVIEW
A Dowson
Headache is a universal symptom. However, despite its prevalence and implications for daily living, headache epidemiology and its public health impact have only been partially documented. Most research has focused on migraine, with data on tension-type headache (TTH) being relatively sparse, especially for countries outside Western Europe and North America.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/25907015/time-to-take-tension-type-headache-seriously
#16
EDITORIAL
S Jarvis
No abstract text is available yet for this article.
May 2015: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/24673717/lower-dosing-of-enteric-coated-mycophenolate-sodium-myfortic-can-achieve-target-mycophenolic-acid-exposure-rapidly-in-most-chinese-renal-transplant-patients-a-pilot-study
#17
COMPARATIVE STUDY
H Yin, K Qiu, X P Hu, X B Li, W Wang, L H Liu, X D Zhang
AIMS: There are few pharmacokinetic data for enteric-coated mycophenolate sodium (EC-MPS) in Chinese kidney transplant recipients. Previously, we demonstrated that patients with 540 mg EC-MPS reached target exposure on day 4 after transplantation. The aim of this study was further to confirm that mycophenolic acid (MPA) delivery with a daily total dose 1080 mg EC-MPS is adequate during the early-phase posttransplantation and preliminarily assess the pharmacokinetics after a single dose and multiple doses of EC-MPS in Chinese live-donor kidney transplant recipients...
April 2014: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/24673716/a-single-centre-open-label-prospective-study-of-an-initially-short-term-intensified-dosing-regimen-of-enteric-coated-mycophenolate-sodium-with-reduced-cyclosporine-a-exposure-in-chinese-live-donor-kidney-transplant-recipients
#18
RANDOMIZED CONTROLLED TRIAL
L Cai, F Zeng, B Liu, L Wei, Z Chen, J Jiang
AIMS: The nephrotoxicity of cyclosporine A (CsA) accounts for dysfunction of kidney allografts in the clinic. Short-term intensified dosing using enteric-coated mycophenolate sodium (EC-MPS) may facilitate CsA sparing after kidney transplantation without compromising safety. METHODS: In a 12-month, single-centre open-label prospective trial, 180 de novo live-donor kidney transplant recipients at low-immunological risk were randomised to a low-dose cyclosporine group which received a low dose of cyclosporine, short-term intensified EC-MPS dosing (2160 mg/day to week 6, 1440 mg/day thereafter) and corticosteroids or a standard-dose cyclosporine group which received a standard dose of cyclosporine, standard EC-MPS dosing (1440 mg/day) and corticosteroids...
April 2014: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/24673715/efficacy-and-safety-of-enteric-coated-mycophenolate-sodium-in-patients-with-de-novo-and-maintenance-renal-transplantation
#19
COMPARATIVE STUDY
Y Qin, F Zhang, B Shen, Y Liu, J Qiu, Y Guo, Y Fan
AIMS: To evaluate the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS) in renal transplant patients treated de novo and for maintenance. METHODS: The efficacy and safety data of EC-MPS in renal transplant patients treated de novo and for maintenance in our hospital from July 2009 to March 2013 were reviewed. RESULTS: Thirty-one patients treated with EC-MPS de novo were included: there were 16 male and 15 female patients...
April 2014: International Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/24673714/which-is-more-suitable-for-kidney-transplantation-at-the-early-post-transplantation-phase-in-china-low-dosing-or-standard-dosing-of-enteric-coated-mycophenolate-sodium
#20
RANDOMIZED CONTROLLED TRIAL
C Ding, W Xue, P Tian, X Ding, X Pan, H Xiang, X Tian, Y Li, J Zheng
AIMS: To investigate the pharmacokinetics of enteric-coated mycophenolate sodium (EC-MPS) and the clinical outcome in kidney transplant recipients in the early post-transplantation phase. Then explain which regimen is more suitable for Chinese renal transplant recipients. METHODOLOGY: In total, 60 de novo kidney transplant recipients treated with tacrolimus and steroids were randomised to receive EC-MPS at standard dose (SD; 1440 mg/day; n = 28) or low dose (LD; 1080 mg/day; n = 32)...
April 2014: International Journal of Clinical Practice. Supplement
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