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Apoptosis: An International Journal on Programmed Cell Death

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https://www.readbyqxmd.com/read/30612317/cancer-therapeutics-based-on-bcl-2-functional-conversion
#1
Martin C Pearce, Arnold C Satterthwait, Xiao-Kun Zhang, Siva Kumar Kolluri
No abstract text is available yet for this article.
January 5, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30610505/clotam-enhances-anti-proliferative-effect-of-vincristine-in-ewing-sarcoma-cells
#2
Sagar Shelake, Umesh T Sankpal, Don Eslin, W Paul Bowman, Jerry W Simecka, Sangram Raut, Anish Ray, Riyaz Basha
Current therapeutic strategies used in Ewing sarcoma (ES) especially for relapsed patients have resulted in modest improvements in survival over the past 20 years. Combination therapeutic approach presents as an alternative to overcoming drug resistance in metastatic ES. This study evaluated the effect of Clotam (tolfenamic acid or TA), a small molecule and inhibitor of Specificity protein1 (Sp1) and survivin for sensitizing ES cell lines to chemotherapeutic agent, vincristine (VCR). ES cells (CHLA-9 and TC-32) were treated with TA or VCR or TA + VCR (combination), and cell viability was assessed after 24/48/72 h...
January 4, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30610504/microrna-663-antagonizes-apoptosis-antagonizing-transcription-factor-to-induce-apoptosis-in-epithelial-cells
#3
M R Benakanakere, J Zhao, L Finoti, R Schattner, M Odabas-Yigit, D F Kinane
MicroRNAs are small functional RNAs that modulate various biological processes in cells by interfering with gene translation. We have previously demonstrated that certain miRNAs play a crucial role in the innate immune responses of human oral epithelial cells to Porphyromonas gingivalis. While addressing the mechanisms of P. gingivalis induced apoptosis in these cells, we discovered that certain miRNAs are upregulated upon stimulation with live bacteria. These upregulated miRNAs include hsa-miR-584, hsa-miR-572, hsa-miR-210, hsa-miR-492, hsa-miR-623 and hsa-miR-663...
January 4, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30603830/oxidative-stress-generated-by-irradiation-of-a-zinc-ii-phthalocyanine-induces-a-dual-apoptotic-and-necrotic-response-in-melanoma-cells
#4
Federico Valli, María C García Vior, Leonor P Roguin, Julieta Marino
Melanoma is an aggressive form of skin carcinoma, highly resistant to traditional therapies. Photodynamic therapy (PDT) is a non-invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. In this work we evaluated the effect of a cationic zinc(II) phthalocyanine (Pc13) as photosensitizer on a panel of melanoma cells. Incubation with Pc13 and irradiation induced a concentration and light dose-dependent phototoxicity. In order to study the mechanism underlying Pc13-related cell death and to compare the effect of different doses of PDT, the most sensitive melanoma B16F0 cells were employed...
January 2, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30600425/cell-death-in-the-human-infant-central-nervous-system-and-in-sudden-infant-death-syndrome-sids
#5
Natalie Ambrose, Michael Rodriguez, Karen A Waters, Rita Machaalani
The brainstem has been a focus of sudden infant death syndrome (SIDS) research with amassing evidence of increased neuronal apoptosis. The present study extends the scope of brain regions examined and determines associations with known SIDS risk factors. Immunohistochemical expression of cell death markers, active caspase-3 and TUNEL, was studied in 37 defined brain regions in infants (aged 1-12 months) who died suddenly and unexpectedly (SUDI). A semi-quantitative mean score of marker expression was derived for each region and scores compared between three SUDI subgroups: explained SUDI (eSUDI; n = 7), SIDS I (n = 8) and SIDS II (n = 13)...
January 2, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30578463/mechanisms-of-cell-death-induced-by-arginase-and-asparaginase-in-precursor-b-cell-lymphoblasts
#6
Lucy E Métayer, Richard D Brown, Saskia Carlebur, G A Amos Burke, Guy C Brown
Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia. We compared arginase cytotoxicity with asparaginase, currently used in pre-B ALL treatment, and characterised the forms of cell death induced in a pre-B ALL cell line 697. Arginase and asparaginase both efficiently killed 697 cells and mature B lymphoma cell line Ramos, but neither enzyme killed normal lymphocytes. Arginase depleted cellular arginine, and arginase-treated media induced cell death, blocked by addition of arginine or arginine-precursor citrulline...
December 21, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30552537/cornification-of-nail-keratinocytes-requires-autophagy-for-bulk-degradation-of-intracellular-proteins-while-sparing-components-of-the-cytoskeleton
#7
Karin Jaeger, Supawadee Sukseree, Shaomin Zhong, Brett S Phinney, Veronika Mlitz, Maria Buchberger, Marie Sophie Narzt, Florian Gruber, Erwin Tschachler, Robert H Rice, Leopold Eckhart
Epidermal keratinocytes undergo cornification to form the cellular building blocks of hard skin appendages such as nails and the protective layer on the surface of the skin. Cornification requires the cross-linking of structural proteins and the removal of other cellular components to form mechanically rigid and inert corneocytes. Autophagy has been proposed to contribute to this intracellular remodelling process, but its molecular targets in keratinocytes, if any, have remained elusive. Here, we deleted the essential autophagy factor Atg7 in K14-positive epithelia of mice and determined by proteomics the impact of this deletion on the abundance of individual proteins in cornified nails...
December 14, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30519834/a-thiopyran-derivative-with-low-murine-toxicity-with-therapeutic-potential-on-lung-cancer-acting-through-a-nf-%C3%AE%C2%BAb-mediated-apoptosis-to-pyroptosis-switch
#8
Liping Chen, Bixia Weng, Huimin Li, Haonan Wang, Qian Li, Xiaoyan Wei, Hui Deng, Sicen Wang, Chengxi Jiang, Renyu Lin, Jianzhang Wu
Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway...
December 5, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30515612/ng25-a-novel-inhibitor-of-tak1-suppresses-kras-mutant-colorectal-cancer-growth-in-vitro-and-in-vivo
#9
Qizhao Ma, Ling Gu, Shiping Liao, Yanjiang Zheng, Shu Zhang, Yueyan Cao, Ji Zhang, Yufang Wang
KRAS mutations are one of the most prevalent genetic alterations in colorectal cancer (CRC). Although directly targeting KRAS still is a challenge in anti-cancer therapies, alternatively inhibiting KRAS related signaling pathways has been approached effectively. Here we firstly reported that MAP kinase, transforming growth factor-β-activated kinase 1 (TAK1), commonly expressed in CRC cell lines and significantly associated with KRAS mutation status. Inhibition of TAK1 by the small molecular inhibitor NG25 could inhibit CRC cells proliferation in vitro and in vivo, especially in KRAS-mutant cells...
December 4, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30506375/correlation-between-microbes-and-colorectal-cancer-tumor-apoptosis-is-induced-by-sitosterols-through-promoting-gut-microbiota-to-produce-short-chain-fatty-acids
#10
Hang Ma, Yang Yu, Meimei Wang, Zhaoxing Li, Heshan Xu, Cheng Tian, Jian Zhang, Xiaoli Ye, Xuegang Li
The diversity of the bacterial community in the gut is closely related to human health. Gut microbes accomplish multiple physiological and biochemical functions. Sitosterols are a series of phytochemicals that have multiple pharmacological activities and are used as cholesterol-lowering drugs in clinical practice. In this study, we investigated the roles of bacteria and short-chain fatty acids (SCFAs) to the anti-colorectal cancer (anti-CRC) effects of sitosterols in BALB/c nude mice. Sitosterols were administered orally and gut microbiota composition and intestinal SCFAs changes were analyzed...
November 30, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30498998/a-real-time-bioluminescent-annexin-v-assay-for-the-assessment-of-apoptosis
#11
Kevin Kupcho, John Shultz, Robin Hurst, Jim Hartnett, Wenhui Zhou, Thomas Machleidt, Jamison Grailer, Tracy Worzella, Terry Riss, Dan Lazar, James J Cali, Andrew Niles
Apoptosis is an important and necessary cell death program which promotes homeostasis and organismal survival. When dysregulated, however, it can lead to a myriad of pathologies from neurodegenerative diseases to cancer. Apoptosis is therefore the subject of intense study aimed at dissecting its pathways and molecular mechanisms. Although many assay methods exist for confirming whether an apoptotic response has occurred in vitro, most methods are destructive and involve laborious operator effort or specialized instrumentation...
November 29, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30430397/molecular-mechanisms-of-apoptosis-and-autophagy-elicited-by-combined-treatment-with-oridonin-and-cetuximab-in-laryngeal-squamous-cell-carcinoma
#12
Shijie Cao, Yiyuan Huang, Qiang Zhang, Fangjin Lu, Paul Owusu Donkor, Yan Zhu, Feng Qiu, Ning Kang
Combined oridonin (ORI), a natural and safe kaurene diterpenoid isolated from Rabdosia rubescens, and cetuximab (Cet), an anti-EGFR monoclonal antibody, have been reported to exert synergistic anti-tumor effects against laryngeal squamous cell carcinoma (LSCC) both in vitro and in vivo by our group. In the present study, we further found that ORI/Cet treatment not only resulted in apoptosis but also induced autophagy. AMPK/mTOR signaling pathway was found to be involved in the activation of autophagy in ORI/Cet-treated LSCC cells, which is independent of p53 status...
November 14, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30426280/pppde1-promotes-hepatocellular-carcinoma-development-by-negatively-regulate-p53-and-apoptosis
#13
Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Chen
We have previously identified that PPPDE1 is a deubiquitinase (DUB) belonging to a cysteine isopeptidase family. Here we sought to explore the biological significance of PPPDE1 in hepatocellular carcinoma and its underlying molecular mechanism. In the present study, we found that amplification and overexpression of PPPDE1 were associated with poor prognosis in hepatocellular carcinoma (HCC). We also demonstrated that knocking down of PPPDE1 could significantly block the clonal growth and tumorigenicity of human HCC cells, which revealed a critical role for PPPDE1 in HCC development...
November 13, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30421279/correction-to-ready-player-one-autophagy-shapes-resistance-to-photodynamic-therapy-in-cancers
#14
Xian Duan, Bo Chen, Yanan Cui, Lin Zhou, Chenkai Wu, Zhulin Yang, Yu Wen, Xiongying Miao, Qinglong Li, Li Xiong, Jun He
The below funding information was not submitted and hence not included in the original publication. The funding information is given below.
November 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30390185/correction-to-licochalcone-a-induces-apoptosis-through-endoplasmic-reticulum-stress-via-a-phospholipase-c%C3%AE-1-ca-2-and-reactive-oxygen-species-dependent-pathway-in-hepg2-human-hepatocellular-carcinoma-cells
#15
A-Young Choi, Ji Hyun Choi, Keun-Young Hwang, Yeon Ju Jeong, Wonchae Choe, Kyung-Sik Yoon, Joohun Ha, Sung Soo Kim, Jang Hyun Youn, Eui-Ju Yeo, Insug Kang
The original version of this article contained mistakes in figures. The western blot data for pro-caspase-3 and cleaved caspase-3 (Fig. 1d), β-actin (Fig. 1d), PLCγ1 (Fig. 5d), and eIF2α (Fig. 7d) are incorrect. The corrected Figs. 1d, 5d, and 7d are shown below. The corrections do not influence either the validity of the published data or the conclusion described in the article.
November 2, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30390184/correction-to-apicidin-induces-endoplasmic-reticulum-stress-and-mitochondrial-dysfunction-associated-apoptosis-via-phospholipase-c%C3%AE-1-and-ca-2-dependent-pathway-in-mouse-neuro-2a-neuroblastoma-cells
#16
Ji Hyun Choi, Jung Yeon Lee, A-Young Choi, Keun-Young Hwang, Wonchae Choe, Kyung-Sik Yoon, Joohun Ha, Eui-Ju Yeo, Insug Kang
The original version of this article contained a mistake in the figure. The Ca2 + confocal image for the 2-APB/Apicidin-120 min in Fig. 5d is incorrect. The correction does not influence either the validity of the published data or the conclusion described in the article. The corrected Fig. 5d is given below.
November 2, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30387007/sigma-1-receptor-protects-against-endoplasmic-reticulum-stress-mediated-apoptosis-in-mice-with-cerebral-ischemia-reperfusion-injury
#17
Xuemei Zhao, Lin Zhu, Danyang Liu, Tianyan Chi, Xuefei Ji, Peng Liu, Xuexue Yang, Xinxin Tian, Libo Zou
Reports have showed that Sigma-1 receptor (Sig-1R) activation can protect neurons against cerebral ischemia/reperfusion (I/R) injury in mice and alleviate endoplasmic reticulum (ER) stress in cultured cells, but little known is about the protective role of Sig-1R on ER stress induced by cerebral I/R. The purpose of this study was to determine whether Sig-1R exerts a protective effect against ER stress-mediated apoptosis in cerebral I/R using a 15-min bilateral common carotid artery occlusion (BCCAO) mouse model...
November 1, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30357572/klotho-modulates-er-mediated-signaling-crosstalk-between-prosurvival-autophagy-and-apoptotic-cell-death-during-lps-challenge
#18
Jennifer Mytych, Przemyslaw Solek, Marek Koziorowski
Bacterial endotoxins have been shown to induce prosurvival autophagy or apoptosis in fibroblasts and thus impair the wound healing process. Endoplasmic reticulum has been proposed as a molecular switch between these processes and klotho protein possessing pleiotropic characteristics seems to be involved in both processes, however the exact molecular mechanism is unknown. In this study, we have evaluated the effect of klotho silencing on human fibroblasts exposed to a non-toxic dose of lipopolysaccharide in terms of in vitro wound healing ability...
October 24, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30293220/correction-to-release-of-overexpressed-cypb-activates-erk-signaling-through-cd147-binding-for-hepatoma-cell-resistance-to-oxidative-stress
#19
Kiyoon Kim, Hunsung Kim, Kwon Jeong, Min Hyung Jung, Bum-Soo Hahn, Kyung-Sik Yoon, Byung Kwan Jin, Geon-Ho Jahng, Insug Kang, Joohun Ha, Wonchae Choe
The original version of this article contained a mistake. The bands for HA Tag and t-ERK in Figs. 2d, 2h, 3d are incorrect. The author informs that these errors had no influence in the scientific content of the paper. The corrected figures (Figs. 2 and 3) are given below.
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30288638/ready-player-one-autophagy-shapes-resistance-to-photodynamic-therapy-in-cancers
#20
REVIEW
Xian Duan, Bo Chen, Yanan Cui, Lin Zhou, Chenkai Wu, Zhulin Yang, Yu Wen, Xiongying Miao, Qinglong Li, Li Xiong, Jun He
Photodynamic therapy (PDT) is a procedure used in cancer therapy that has been shown to be useful for certain indications. Considerable evidence suggests that PDT might be superior to conventional modalities for some indications. In this report, we examine the relationship between PDT responsiveness and autophagy, which can exert a cytoprotective effect. Autophagy is an essential physiological process that maintains cellular homeostasis by degrading dysfunctional or impaired cellular components and organelles via a lysosome-based pathway...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
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