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Apoptosis: An International Journal on Programmed Cell Death

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https://www.readbyqxmd.com/read/28702823/etoposide-and-doxorubicin-enhance-the-sensitivity-of-triple-negative-breast-cancers-through-modulation-of-trail-dr5-axis
#1
Sarita Das, Neha Tripathi, Sumit Siddharth, Anmada Nayak, Deepika Nayak, Chinmayee Sethy, Prasad V Bharatam, Chanakya Nath Kundu
Death receptor 5 (DR5) is an important target for development of anticancer agents against triple-negative breast cancer (TNBC). Recently, we reported the molecular level details for the modulation of TRAIL-DR5 axis by quinacrine (QC) in breast cancer cells. In this work, the DR5 mediated anticancer potential of topoisomerase inhibitor etoposide (ET) and doxorubicin (DOX) against TNBC has been evaluated. ET and DOX enhanced the DR5 expression in TNBC cells, whereas non-topoisomerase inhibitors pifithrin-α (PIF) and dexamethasone (DEX) failed to do so...
July 12, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28685254/kh-tfmdi-a-novel-sirtuin-inhibitor-alters-the-cytoskeleton-and-mitochondrial-metabolism-promoting-cell-death-in-leishmania-amazonensis
#2
Brunno Renato Farias Verçoza, Joseane Lima Prado Godinho, Sara Teixeira de Macedo-Silva, Kilian Huber, Franz Bracher, Wanderley de Souza, Juliany Cola Fernandes Rodrigues
Treatment of leishmaniasis involves the use of antimonials, miltefosine, amphotericin B or pentamidine. However, the side effects of these drugs and the reports of drug-resistant parasites demonstrate the need for new treatments that are safer and more efficacious. Histone deacetylase inhibitors are a new class of compounds with potential to treat leishmaniasis. Herein, we evaluated the effects of KH-TFMDI, a novel histone deacetylase inhibitor, on Leishmania amazonensis promastigotes and intracellular amastigotes...
July 6, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28677094/bisdemethoxycurcumin-sensitizes-cisplatin-resistant-lung-cancer-cells-to-chemotherapy-by-inhibition-of-ca916798-and-pi3k-akt-signaling
#3
Hai-Jing Wang, Zai-Xing Yang, Xiao-Tian Dai, Yong-Feng Chen, He-Ping Yang, Xiang-Dong Zhou
Curcumin, a dietary supplement or herbal medicine from Curcuma longa, has shown antitumor activity in different cancer cell lines and clinical trials. CA916798, a novel protein, is overexpressed in multidrug-resistant tumor cells. This study aimed to assess the effects of curcumin on regulating chemosensitivity in cisplatin-resistant non-small cell lung cancer (NSCLC) cells in vitro and to explore the underlying molecular mechanisms. Human cisplatin-sensitive A549 and cisplatin-resistant A549/CDDP lung adenocarcinoma cells were treated with curcumin to assess cell viability and gene modulations using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting...
July 4, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28677093/structural-aspects-of-transglutaminase-2-functional-structural-and-regulatory-diversity
#4
REVIEW
Chang Sup Lee, Hyun Ho Park
Transglutaminase 2 (TG2) is a multi-functional protein that has both protein cross-linking and guanosine 5'-triphosphate (GTP) hydrolysis activities. The activities of this protein are controlled by many cellular factors, including calcium (Ca(2+)) and GTP, and have been implicated in several physiological activities, including apoptosis, angiogenesis, wound healing, cellular differentiation, neuronal regeneration, and bone development. TG2 is linked to many human diseases such as inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis, and various cancers and is one of the most dynamic enzymes in terms of its functions, structures, and regulatory mechanisms...
July 4, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28677092/amelioration-of-bleomycin-induced-pulmonary-fibrosis-by-chlorogenic-acid-through-endoplasmic-reticulum-stress-inhibition
#5
Yi-Chun Wang, Jing Dong, Jing Nie, Ji-Xiang Zhu, Hui Wang, Qiong Chen, Jun-Yi Chen, Jia-Mei Xia, Wei Shuai
To investigate the inhibitory effects of chlorogenic acid on pulmonary fibrosis and the internal mechanisms in vivo and in vitro. 30 male BALB/C mice were randomized into 5 groups: control group, pulmonary fibrosis model group, low, middle and high dose of chlorogenic acid groups. Mice in pulmonary fibrosis model group were administered 5.0 mg/kg bleomycin with intracheal instillation and mice in 3 chlorogenic acid groups were treated with chlorogenic acid every day for 28 days after bleomycin administration...
July 4, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28660311/astragalus-polysaccharides-inhibits-cell-growth-and-pro-inflammatory-response-in-il-1%C3%AE-stimulated-fibroblast-like-synoviocytes-by-enhancement-of-autophagy-via-pi3k-akt-mtor-inhibition
#6
Qingliang Meng, Xuzhao Du, Huilian Wang, Huimin Gu, Junping Zhan, Zipeng Zhou
The hyperplastic growth of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and inflammatory response are pathological hallmarks of RA. It has been reported that Astragalus polysaccharides (APS) possess appreciable anti-inflammatory activity against adjuvant-induced arthritis. Nevertheless, little is known about the role and detailed mechanism underlying the therapeutic effects of APS in RA. This study demonstrated that administration of APS dose-dependently impaired cell viability, increased cell apoptosis by decreasing Bcl-2 expression, increasing Bax expression and Caspase3 activity in IL-1β-stimulated RSC-364 cells and RA-FLS...
June 28, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28653224/acquisition-of-anoikis-resistance-promotes-alterations-in-the-ras-erk-and-pi3k-akt-signaling-pathways-and-matrix-remodeling-in-endothelial-cells
#7
Ana Paula de Sousa Mesquita, Silvana de Araújo Lopes, Paulo Castanho A Pernambuco Filho, Helena B Nader, Carla Cristina Lopes
Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix. Anoikis resistance is a critical mechanism in tumor metastasis. Cancer cells deregulate and adapt their metabolism to survive in the absence of adhesion, spreading metastases to distant organs. These adaptations include abnormal regulation of growth factor receptors activating prosurvival signaling pathways, such as the Ras/ERK and PI3K/Akt pathways, and extracellular matrix remodeling, leading to metastasis by an increase of invasiveness and inhibiting anoikis...
June 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28653223/multi-targeted-therapy-of-everolimus-in-kaposi-s-sarcoma-associated-herpes-virus-infected-primary-effusion-lymphoma
#8
Suchitra Mohanty, Amit Kumar, Piyanki Das, Sushil Kumar Sahu, Tathagata Choudhuri
Kaposi's sarcoma associated herpes virus (KSHV) infected primary effusion lymphoma (PEL) is a rare aggressive form of non-Hodgkin's lymphoma of B cells. KSHV latent and lytic antigens modulate several host cellular signalling pathways especially mammalian target of rapamycin (mTOR), STAT-3 and nuclear factor-kappa B (NF-κB) for rapid tumor progression and immune evasion. Current chemotherapeutic strategies are becoming ineffective as they kill only dividing cells and inefficient to target molecular pathways crucial for active virus replication and its survival...
June 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28647884/fluoxetine-induces-apoptosis-through-endoplasmic-reticulum-stress-via-mitogen-activated-protein-kinase-activation-and-histone-hyperacetylation-in-sk-n-be-2-m17-human-neuroblastoma-cells
#9
Ji Hyun Choi, Yeon Ju Jeong, Ah-Ran Yu, Kyung-Sik Yoon, Wonchae Choe, Joohun Ha, Sung Soo Kim, Eui-Ju Yeo, Insug Kang
Fluoxetine (FLX) is an antidepressant drug that belongs to the class of selective serotonin reuptake inhibitors. FLX is known to induce apoptosis in multiple types of cancer cells. In this study, the molecular mechanisms underlying the anti-cancer effects of FLX were investigated in SK-N-BE(2)-M17 human neuroblastoma cells. FLX induced apoptotic cell death, activation of caspase-4, -9, and -3, and expression of endoplasmic reticulum (ER) stress-associated proteins, including C/EBP homologous protein (CHOP)...
June 24, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28643197/ampk-is-activated-early-in-cerebellar-granule-cells-undergoing-apoptosis-and-influences-vadc1-phosphorylation-status-and-activity
#10
A Bobba, E Casalino, G Amadoro, V A Petragallo, A Atlante
The neurodegeneration of cerebellar granule cells, after low potassium induced apoptosis, is known to be temporally divided into an early and a late phase. Voltage-dependent anion channel-1 (VDAC1) protein, changing from the closed inactive state to the active open state, is central to the switch between the early and late phase. It is also known that: (i) VDAC1 can undergo phosphorylation events and (ii) AMP-activated protein kinase (AMPK), the sensor of cellular stress, may have a role in neuronal homeostasis...
June 22, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28643196/genetic-variants-in-cell-death-pathway-genes-and-hbv-related-hepatocellular-carcinoma-among-a-chinese-han-population
#11
Fei Liu, Fuqiang Li, Limei Luo, Hanteng Yang, Yonggang Wei, Wentao Wang, Lvnan Yan, Tianfu Wen, Jiayin Yang, Bo Li
Cell death pathway plays an important role in apoptosis, and corruption of this signaling pathway has been shown to participate in carcinogenesis. We aimed at determining whether genetic variants in CASP8, CASP10 and CFLAR influence the development and clinical outcomes of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A hospital-based case-control study, including 600 HCC cases and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk and prognosis in a Chinese Han population...
June 22, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28616662/perifosine-enhances-bevacizumab-induced-apoptosis-and-therapeutic-efficacy-by-targeting-pi3k-akt-pathway-in-a-glioblastoma-heterotopic-model
#12
Sara Ramezani, Nasim Vousooghi, Fatemeh Ramezani Kapourchali, Mohammad Taghi Joghataei
Bevacizumab (BVZ) as an antiangiogenesis therapy leads to a transient therapeutic efficacy in high-grade glioma. However, the proapoptotic potential of BVZ has not been well elucidated, yet. There is also a tumor resistance to BVZ that is linked to post-treatment metalloproteinases and AKT activities. Herein, the association between therapeutic efficacy and putative proapoptotic activity of low-dose BVZ either alone or in combination with a specific inhibitor of AKT called perifosine (PRF), in a glioma model was investigated...
June 14, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28612103/dihydromyricetin-protects-human-umbilical-vein-endothelial-cells-from-injury-through-erk-and-akt-mediated-nrf2-ho-1-signaling-pathway
#13
Yun Luo, Shan Lu, Xi Dong, Lijia Xu, Guibo Sun, Xiaobo Sun
Atherosclerosis-related cardiovascular disease is the predominant cause of death worldwide. Ox-LDL-induced vascular endothelial cell injury is a major factor in the pathogenesis of atherosclerosis. Dihydromyricetin (DMY) is a flavonoid extracted from vine tea that exerts multiple pharmacological activities, including cardio-protective, anti-tumor, and anti-oxidative effects. However, it is unreported that DMY shows protective effects on ox-LDL-induced endothelial cell injury. In this study, we used an ox-LDL injured human umbilical vein endothelial cell (HUVEC) in vitro model to explore the protective effects and mechanism of DMY...
June 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28601953/fludarabine-inhibits-stat1-mediated-up-regulation-of-caspase-3-expression-in-dexamethasone-induced-osteoblasts-apoptosis-and-slows-the-progression-of-steroid-induced-avascular-necrosis-of-the-femoral-head-in-rats
#14
Zhenhua Feng, Wenhao Zheng, Qian Tang, Liang Cheng, Hang Li, Wenfei Ni, Xiaoyun Pan
Steroid-induced avascular necrosis of the femoral head (SANFH) is a major limitation of long-term or excessive clinical administration of glucocorticoids. Fludarabine, which is a compound used to treat various hematological malignancies, such as chronic lymphocytic leukemia, acts by down-regulating signal transducer and activator of transcription 1 (STAT1) by inhibiting STAT1 phosphorylation in both normal and cancer cells. This study assessed the effects of fludarabine in vitro (primary murine osteoblasts) and in vivo (rat SANFH model)...
June 10, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28577196/role-of-a-novel-benzoxazine-derivative-in-the-chemosensitization-of-colon-cancer
#15
Rejitha Suraj, Suraj Radhamani, Terri Meehan-Andrews, Christopher Bradley
The concept to fight against tumour resistance is to use chemosensitizers that selectively sensitize tumour cells to chemotherapeutic drugs without affecting normal tissue. In this study, the chemosensitizing potential of a novel benzoxazine derivative in combination with Doxorubicin, a DNA damaging chemotherapeutic drug was evaluated. The results of this study showed that the compound LTUR6 is a potent chemosensitizer of Doxorubicin in colon cancer cell lines, HCT116 and HT29. It was also observed that LTUR6 delayed the resolution of Doxorubicin-induced γH2AX, a specific marker of unrepaired DNA DSB, and prolonged cell cycle arrest in both cell lines...
June 2, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28643198/urokinase-plasminogen-activator-protects-cardiac-myocytes-from-oxidative-damage-and-apoptosis-via-hogg1-induction
#16
Philipp J Hohensinner, Nikol Takacs, Christoph Kaun, Barbara Thaler, Konstantin A Krychtiuk, Stefan Pfaffenberger, Arezu Aliabadi, Andreas Zuckermann, Kurt Huber, Johann Wojta
The role of uPA in tissue remodeling and cell migration is already well established. In addition, uPA was reported to stabilize p53, a key cell cycle control, DNA repair and apoptosis initiation protein. We aimed to determine the role of uPA-uPAR signaling towards cell survival or apoptosis in human adult cardiac myocytes (HACM). HACM were stimulated with uPA and DNA damage was inflicted by incubating cells with 200 µM H2O2. To analyze for apoptotic cells we applied TUNEL staining. Oxidative damage foci were analyzed by staining for 8-oxoguanine base pairs...
August 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28623512/phosphatidylethanolamine-targeting-for-cell-death-imaging-in-early-treatment-response-evaluation-and-disease-diagnosis
#17
REVIEW
Filipe Elvas, Sigrid Stroobants, Leonie Wyffels
Phosphatidylethanolamine (PE) is one of the most abundant phospholipids in mammalian plasma membranes. In healthy cells, PE resides predominantly in the inner leaflet of the cell membrane. In dead or dying cells on the other hand, PE is externalized to the outer leaflet of the plasma membrane. The exposure of PE on the cell surface has therefore become an attractive target for the molecular imaging of cell death using single-photon emission computed tomography (SPECT) and positron emission tomography (PET)...
August 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28466106/augmenter-of-liver-regeneration-regulates-autophagy-in-renal-ischemia-reperfusion-injury-via-the-ampk-mtor-pathway
#18
Tao Pu, Xiao-Hui Liao, Hang Sun, Hui Guo, Xiao Jiang, Jun-Bo Peng, Ling Zhang, Qi Liu
Autophagy may have protective effects in renal ischemia-reperfusion (I/R) injury, although the underlying mechanisms remain unclear. Augmenter of liver regeneration (ALR), a widely distributed multifunctional protein that is originally identified as a hepatic growth factor, may participate in the process of autophagy. To investigate the role of ALR in autophagy, ALR expression is knocked-down in human kidney 2 (HK-2) cells with short hairpin RNA lentivirals. Then, the level of autophagy is measured in the shRNA/ALR group and the shRNA/control group in an in vitro model of ischemia-reperfusion (I/R)...
July 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28455824/diallyl-trisulfide-ameliorates-myocardial-ischemia-reperfusion-injury-by-reducing-oxidative-stress-and-endoplasmic-reticulum-stress-mediated-apoptosis-in-type-1-diabetic-rats-role-of-sirt1-activation
#19
Liming Yu, Shu Li, Xinlong Tang, Zhi Li, Jian Zhang, Xiaodong Xue, Jinsong Han, Yu Liu, Yuji Zhang, Yong Zhang, Yinli Xu, Yang Yang, Huishan Wang
Diallyl trisulfide (DATS) protects against apoptosis during myocardial ischemia-reperfusion (MI/R) injury in diabetic state, although the underlying mechanisms remain poorly defined. Previously, we and others demonstrated that silent information regulator 1 (SIRT1) activation inhibited oxidative stress and endoplasmic reticulum (ER) stress during MI/R injury. We hypothesize that DATS reduces diabetic MI/R injury by activating SIRT1 signaling. Streptozotocin (STZ)-induced type 1 diabetic rats were subjected to MI/R surgery with or without perioperative administration of DATS (40 mg/kg)...
July 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28439677/ap-2%C3%AE-reverses-vincristine-induced-multidrug-resistance-of-sgc7901-gastric-cancer-cells-by-inhibiting-the-notch-pathway
#20
Wei Lian, Li Zhang, Long Yang, Wensheng Chen
Multidrug resistance (MDR) remains a major clinical obstacle in the treatment of gastric cancer (GC) since it causes tumor recurrence and metastasis. The transcription factor activator protein-2α (AP-2α) has been implicated in drug-resistance in breast cancer; however, its effects on MDR of gastric cancer are far from understood. In this study, we aimed to explore the effects of AP-2α on the MDR in gastric cancer cells selected by vincristine (VCR). Decreased AP-2α levels were markedly detected by RT-PCR and Western blot in gastric cancer cell lines (BGC-823, SGC-7901, AGS, MKN-45) compared with that in the gastric epithelial cell line (GES-1)...
July 2017: Apoptosis: An International Journal on Programmed Cell Death
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