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Apoptosis: An International Journal on Programmed Cell Death

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https://www.readbyqxmd.com/read/28102458/defining-the-morphologic-features-and-products-of-cell-disassembly-during-apoptosis
#1
LETTER
Rochelle Tixeira, Sarah Caruso, Stephanie Paone, Amy A Baxter, Georgia K Atkin-Smith, Mark D Hulett, Ivan K H Poon
No abstract text is available yet for this article.
January 19, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28084570/synthesis-and-evaluation-of-a-radiolabeled-bis-zinc-ii-cyclen-complex-as-a-potential-probe-for-in-vivo-imaging-of-cell-death
#2
Hongliang Wang, Zhifang Wu, Sijin Li, Kongzhen Hu, Ganghua Tang
The exposition of phosphatidylserine (PS) from the cell membrane is associated with most cell death programs (apoptosis, necrosis, autophagy, mitotic catastrophe, etc.), which makes PS an attractive target for overall cell death imaging. To this end, zinc(II) macrocycle coordination complexes with cyclic polyamine units as low-molecular-weight annexin mimics have a selective affinity for biomembrane surfaces enriched with PS, and are therefore useful for detection of cell death. In the present study, a (11)C-labeled zinc(II)-bis(cyclen) complex ((11)C-CyclenZn2) was prepared and evaluated as a new positron emission tomography (PET) probe for cell death imaging...
January 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28083721/caspase-dependent-and-independent-mechanisms-of-apoptosis-across-gestation-in-a-sheep-model-of-placental-insufficiency-and-intrauterine-growth-restriction
#3
Troy Monson, Tanner Wright, Henry L Galan, Paul R Reynolds, Juan A Arroyo
Increased placental apoptosis is a hallmark of intrauterine growth restricted (IUGR). Several molecules have been shown to be involved in the control of apoptosis during this disease. Our objective was to determine the expression of Bcl2, Bax, phospho XIAP, AIF, caspase 3 and 9, and telomerase activity across gestation in an ovine hyperthermia-induced model of IUGR. Pregnant sheep were placed in hyperthermic (HT) conditions to induce IUGR along with age-matched controls. Placental tissues were collected at 55 (early), 95 (mid-gestation) and 130 (near-term) days of gestational age (dGA) to determine the expression of apoptotic molecules during the development of IUGR...
January 12, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28078537/sirt2-mediated-foxo3a-deacetylation-drives-its-nuclear-translocation-triggering-fasl-induced-cell-apoptosis-during-renal-ischemia-reperfusion
#4
Yan Wang, Yu Mu, Xiaorui Zhou, Huaixue Ji, Xing Gao, Wen Wen Cai, Qiuhua Guan, Tie Xu
We have found that Fas/FasL-mediated "extrinsic" pathway promoted cell apoptosis induced by renal ischemic injury. This study is to elucidate the upstream mechanism regulating FasL-induced extrinsic pathway during renal ischemia/reperfusion. Results demonstrated that when SIRT2 was activated by renal ischemia/reperfusion, activated SIRT2 could bind to and deacetylate FOXO3a, promoting FOXO3a nuclear translocation which resulted in an increase of nuclear FOXO3a along with FasL expression and activation of caspase8 and caspase3, triggering cell apoptosis during renal ischemia/reperfusion...
January 11, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28035493/methods-to-detect-apoptotic-cell-death
#5
Gaspar Banfalvi
In concert with the increased understanding that there are many ways for cells to die, several methods have been developed to detect cell death. The classification of cell death posed some difficulties that were overcome by implementing strict selection criteria that should also apply to the detection methods. The selection of assays is based on morphological criteria and distinguishable marks of apoptotic patways. The detection of apoptosis includes methods related to membrane alterations, DNA fragmentation, cytotoxicity and cell proliferation, mitochondrial damage, immunological detection and mechanism based assays...
December 30, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28012060/adipocyte-microenvironment-promotes-bclxl-expression-and-confers-chemoresistance-in-ovarian-cancer-cells
#6
Carlos Cardenas, Michele K Montagna, Mary Pitruzzello, Eydis Lima, Gil Mor, Ayesha B Alvero
Resistance to mitochondria-initiated apoptosis is a hallmark of chemoresistant cancer stem cells including CD44+/MyD88+ epithelial ovarian cancer (EOC) stem cells. This is controlled by members of the Bcl2 family of proteins, which function as rheostats of mitochondrial stability. We observed a differential expression profile of Bcl2 family members comparing the chemoresistant EOC stem cells and the chemosensitive CD44-/MyD88- EOC cells. Chemoresistant EOC stem cells surprisingly express higher levels of the pro-apoptotic members Bak and Bax compared to the chemosensitive EOC cells...
December 23, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28012059/apoptosis-inducing-factor-aif1-mediates-anacardic-acid-induced-apoptosis-in-saccharomyces-cerevisiae
#7
Suhail Muzaffar, Bharat B Chattoo
Anacardic acid is a medicinal phytochemical that inhibits proliferation of fungal as well as several types of cancer cells. It induces apoptotic cell death in various cell types, but very little is known about the mechanism involved in the process. Here, we used budding yeast Saccharomyces cerevisiae as a model to study the involvement of some key elements of apoptosis in the anacardic acid-induced cell death. Plasma membrane constriction, chromatin condensation, DNA degradation, and externalization of phosphatidylserine (PS) indicated that anacardic acid induces apoptotic cell death in S...
December 23, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28000054/5-flurouracil-disrupts-nuclear-export-and-nuclear-pore-permeability-in-a-calcium-dependent-manner
#8
Kelly J Higby, Melissa M Bischak, Christina A Campbell, Rebecca G Anderson, Sarah A Broskin, Lauren E Foltz, Jarrett A Koper, Audrey C Nickle, Karen K Resendes
Regulation of nuclear transport is an essential component of apoptosis. As chemotherapy induced cell death progresses, nuclear transport and the nuclear pore complex (NPC) are slowly disrupted and dismantled. 5-Fluorouracil (5-FU) and the camptothecin derivatives irinotecan and topotecan, are linked to altered nuclear transport of specific proteins; however, their general effects on the NPC and transport during apoptosis have not been characterized. We demonstrate that 5-FU, but not topotecan, increases NPC permeability, and disrupts Ran-mediated nuclear transport before the disruption of the NPC...
December 20, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27988811/natural-products-as-modulator-of-autophagy-with-potential-clinical-prospects
#9
REVIEW
Peiqi Wang, Lingjuan Zhu, Dejuan Sun, Feihong Gan, Suyu Gao, Yuanyuan Yin, Lixia Chen
Natural compounds derived from living organisms are well defined for their remarkable biological and pharmacological properties likely to be translated into clinical use. Therefore, delving into the mechanisms by which natural compounds protect against diverse diseases may be of great therapeutic benefits for medical practice. Autophagy, an intricate lysosome-dependent digestion process, with implications in a wide variety of pathophysiological settings, has attracted extensive attention over the past few decades...
December 17, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27987050/mycobacterium-tuberculosis-pe_pgrs18-enhances-the-intracellular-survival-of-m-smegmatis-via-altering-host-macrophage-cytokine-profiling-and-attenuating-the-cell-apoptosis
#10
Wenmin Yang, Wanyan Deng, Jie Zeng, Sai Ren, Md Kaisar Ali, Yinzhong Gu, Yangyuling Li, Jianping Xie
Mycobacterium tuberculosis PE/PPE family proteins, named after the presence of conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains at N-terminal, are prevalent in M. tuberculosis genome. The function of most PE/PPE family proteins remains elusive. To characterize the function of PE_PGRS18, the encoding gene was heterologously expressed in M. smegmatis, a nonpathogenic mycobacterium. The recombinant PE_PGRS18 is cell wall associated. M. smegmatis PE_PGRS18 recombinant showed differential response to stresses and altered the production of host cytokines IL-6, IL-1β, IL-12p40 and IL-10, as well as enhanced survival within macrophages largely via attenuating the apoptosis of macrophages...
December 16, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27943067/two-coffins-and-a-funeral-early-or-late-caspase-activation-determines-two-types-of-apoptosis-induced-by-dna-damaging-agents
#11
Manuel Oropesa-Ávila, Patricia de la Cruz-Ojeda, Jesús Porcuna, Marina Villanueva-Paz, Alejandro Fernández-Vega, Mario de la Mata, Isabel de Lavera, Juan Miguel Suarez Rivero, Raquel Luzón-Hidalgo, Mónica Álvarez-Córdoba, David Cotán, Ana Paula Zaderenko, Mario D Cordero, José A Sánchez-Alcázar
Cell cytoskeleton makes profound changes during apoptosis including the organization of an Apoptotic Microtubule Network (AMN). AMN forms a cortical structure which plays an important role in preserving plasma membrane integrity during apoptosis. Here, we examined the cytoskeleton rearrangements during apoptosis induced by camptothecin (CPT), a topoisomerase I inhibitor, in human H460 and porcine LLCPK-1α cells. Using fixed and living cell imaging, we showed that CPT induced two dose- and cell cycle-dependent types of apoptosis characterized by different cytoskeleton reorganizations, time-dependent caspase activation and final apoptotic cell morphology...
December 10, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27900636/cardamonin-represses-proliferation-invasion-and-causes-apoptosis-through-the-modulation-of-signal-transducer-and-activator-of-transcription-3-pathway-in-prostate-cancer
#12
Jingwen Zhang, Sakshi Sikka, Kodappully S Siveen, Jong Hyun Lee, Jae-Young Um, Alan Prem Kumar, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Basappa, Kanchugarakoppal S Rangappa, Gautam Sethi, Kwang Seok Ahn
The pleiotropic transcription factor, signal transducer and activator of transcription 3 (STAT3) is often aberrantly activated in a wide variety of cancers and plays a pivotal role in tumor initiation, promotion and progression. Targeting deregulated STAT3 activation by small molecule inhibitors is generally considered as an important therapeutic strategy. Hence, in the present study, we evaluated the potential of cardamonin (CD), a 2',4'-dihydroxy-6'-methoxychalcone, to modulate STAT3 activation in prostate cancer (PC) cells and found that this chalcone can indeed exhibit significant anticancer effects through negatively regulating STAT3 activation by diverse molecular mechanism(s)...
November 29, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27888447/the-regulation-of-the-mitochondrial-apoptotic-pathway-by-glucocorticoid-receptor-in-collaboration-with-bcl-2-family-proteins-in-developing-t-cells
#13
Lilla Prenek, Ferenc Boldizsár, Réka Kugyelka, Emese Ugor, Gergely Berta, Péter Németh, Timea Berki
Glucocorticoids (GC) are important in the regulation of selection and apoptosis of CD4(+)CD8(+) double-positive (DP) thymocytes. The pronounced GC-sensitivity of DP thymocytes, observed earlier, might be due to the combination of classical (genomic) and alternative (non-genomic) glucocorticoid receptor (GR) signaling events modifying activation or apoptotic pathways. In particular, the previously demonstrated mitochondrial translocation of activated GR in DP thymocytes offered a fascinating explanation for their pronounced GC-induced apoptosis sensitivity...
November 26, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27882436/a-novel-4-6-disubstituted-1-2-4-triazolo-1-3-4-thiadiazole-derivative-inhibits-tumor-cell-invasion-and-potentiates-the-apoptotic-effect-of-tnf%C3%AE-by-abrogating-nf-%C3%AE%C2%BAb-activation-cascade
#14
Raghu Ningegowda, Nanjunda Swamy Shivananju, Peramiyan Rajendran, Basappa, Kanchugarakoppal S Rangappa, Arunachalam Chinnathambi, Feng Li, Raghu Ram Achar, Muthu K Shanmugam, Pradeep Bist, Sulaiman Ali Alharbi, Lina Hsiu Kim Lim, Gautam Sethi, Babu Shubha Priya
Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities. In this study, several novel CBTT derivatives were synthesized and investigated for their possible role as anti-neoplastic agents. The anti-proliferative effect of various CBTT derivatives was analyzed against tumor cell lines by (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT assay. One of the potential CBTT derivative, 5-(3-(2,3-dichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)flurobenzonitrile (DTTF) was found to be the most potent against cervical cancer SiHa cells and exhibited minimal effect against normal cells...
November 24, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27878656/mille-modis-morimur-we-die-in-a-thousand-ways
#15
Gaspar Banfalvi
Dying cells subjected to apoptotic programs are engulfed by neighboring cells or by professional phagocytes, without inflammation or immunological reactions in the tissue where apoptosis takes place. Apoptotic cells release danger-associated project signals to their neighbours, through different molecular patterns, stimulate antigen production and immune responses. Microenvironmental effects with several functional consequences indicate that cell death is a complex process and may take place in several ways...
November 23, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27878398/hsp90-is-a-promising-target-in-gemcitabine-and-5-fluorouracil-resistant-pancreatic-cancer
#16
Tarik Ghadban, Judith L Dibbern, Matthias Reeh, Jameel T Miro, Tung Y Tsui, Ulrich Wellner, Jakob R Izbicki, Cenap Güngör, Yogesh K Vashist
Chemotherapy (CT) options in pancreatic cancer (PC) are limited to gemcitabine and 5-fluorouracil (5-FU). Several identified molecular targets in PC represent client proteins of HSP90. HSP90 is a promising target since it interferes with many oncogenic signaling pathways simultaneously. The aim of this study was to evaluate the efficacy of different HSP90 inhibitors in gemcitabine and 5-FU resistant PC. PC cell lines 5061, 5072 and 5156 were isolated and brought in to culture from patients being operated at our institution...
November 22, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27873035/dmfc-3-5-dimethyl-7-h-furo-3-2-g-chromen-7-one-regulates-bim-to-trigger-bax-and-bak-activation-to-suppress-drug-resistant-human-hepatoma
#17
Jun Xiang, Zhe Wang, Qianqian Liu, Xia Li, Jianguo Sun, Kwok-Pui Fung, Feiyan Liu
3,5-Dimethyl-(7)H-furo[3,2-g]chromen-7-one (DMFC) is a coumarin derivative with anti-cancer activity against human hepatoma cells, but the mechanisms underlying DMFC function in cancer suppression is unknown. In this study, we aimed at elucidating the molecular mechanisms underlying DMFC anti-cancer activity and determining whether DMFC is effective in suppression of drug-resistant human hepatocellular carcinoma. We show here that DMFC effectively suppresses both the parent and the multidrug-resistant hepatoma cell growth in vitro and DMFC suppresses hepatoma cell growth at least in part through inducing tumor cell apoptosis...
November 21, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27864650/heme-oxygenase-1-protects-spinal-cord-neurons-from-hydrogen-peroxide-induced-apoptosis-via-suppression-of-cdc42-mlk3-mkk7-jnk3-signaling
#18
Siyuan Wang, Tao Zhang, Zhen Yang, Jianhua Lin, Bin Cai, Qingfeng Ke, Wenbin Lan, Jinxing Shi, Shiqiang Wu, Wenping Lin
The mechanisms by which oxidative stress induces spinal cord neuron death has not been completely understood. Investigation on the molecular signal pathways involved in oxidative stress-mediated neuronal death is important for development of new therapeutics for oxidative stress-associated spinal cord disorders. In current study we examined the role of heme oxygenase-1 (HO-1) in the modulation of MLK3/MKK7/JNK3 signaling, which is a pro-apoptotic pathway, after treating primary spinal cord neurons with H2O2...
November 18, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27858200/advanced-oxidation-protein-products-induce-chondrocyte-death-through-a-redox-dependent-poly-adp-ribose-polymerase-1-mediated-pathway
#19
Wenbin Ye, Zhaoming Zhong, Siyuan Zhu, Shuai Zheng, Jun Xiao, Shaolian Song, Hui Yu, Qian Wu, Zhen Lin, Jianting Chen
This study aimed to investigate the effect of AOPPs on apoptosis in human chondrocytes. Chondrocytes were treated with AOPPs. Cell death, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, reactive oxygen species (ROS) generation, and the expression of apoptotic proteins were detected in vitro. AOPPs levels were detected by colorimetric method. The results in vitro demonstrated that AOPPs induced cell death in human chondrocyte through a redox-dependent pathway, including RAGE-mediated, NADPH oxidase-dependent ROS generation, and poly (ADP-ribose) polymerase-1 (PARP-1) activation...
November 17, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27848055/knockdown-of-klf11-attenuates-hypoxia-reoxygenation-injury-via-jak2-stat3-signaling-in-h9c2
#20
Yang Li, Xiaojing Shi, Jian Li, Minghui Zhang, Bo Yu
KLF11 is a Krüppel-like factor (KLF) family member, which plays a central role in cardiac hypertrophy and cerebrovascular protection during ischemic insults. However, the roles of KLF11 in hypoxia/reoxygenation (H/R) injury of rat cardiomyocytes H9c2 have not been elucidated. The aim of this study was to evaluate the effects of KLF11 on H/R injury and investigate the molecular mechanisms involved. Here, we found that KLF11 was increased following H/R and reached the highest level with 24 h hypoxia followed by 12 h reoxygenation...
November 15, 2016: Apoptosis: An International Journal on Programmed Cell Death
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