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Apoptosis: An International Journal on Programmed Cell Death

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https://www.readbyqxmd.com/read/30390185/correction-to-licochalcone-a-induces-apoptosis-through-endoplasmic-reticulum-stress-via-a-phospholipase-c%C3%AE-1-ca-2-and-reactive-oxygen-species-dependent-pathway-in-hepg2-human-hepatocellular-carcinoma-cells
#1
A-Young Choi, Ji Hyun Choi, Keun-Young Hwang, Yeon Ju Jeong, Wonchae Choe, Kyung-Sik Yoon, Joohun Ha, Sung Soo Kim, Jang Hyun Youn, Eui-Ju Yeo, Insug Kang
The original version of this article contained mistakes in figures. The western blot data for pro-caspase-3 and cleaved caspase-3 (Fig. 1d), β-actin (Fig. 1d), PLCγ1 (Fig. 5d), and eIF2α (Fig. 7d) are incorrect. The corrected Figs. 1d, 5d, and 7d are shown below. The corrections do not influence either the validity of the published data or the conclusion described in the article.
November 2, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30390184/correction-to-apicidin-induces-endoplasmic-reticulum-stress-and-mitochondrial-dysfunction-associated-apoptosis-via-phospholipase-c%C3%AE-1-and-ca-2-dependent-pathway-in-mouse-neuro-2a-neuroblastoma-cells
#2
Ji Hyun Choi, Jung Yeon Lee, A-Young Choi, Keun-Young Hwang, Wonchae Choe, Kyung-Sik Yoon, Joohun Ha, Eui-Ju Yeo, Insug Kang
The original version of this article contained a mistake in the figure. The Ca2 + confocal image for the 2-APB/Apicidin-120 min in Fig. 5d is incorrect. The correction does not influence either the validity of the published data or the conclusion described in the article. The corrected Fig. 5d is given below.
November 2, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30387007/sigma-1-receptor-protects-against-endoplasmic-reticulum-stress-mediated-apoptosis-in-mice-with-cerebral-ischemia-reperfusion-injury
#3
Xuemei Zhao, Lin Zhu, Danyang Liu, Tianyan Chi, Xuefei Ji, Peng Liu, Xuexue Yang, Xinxin Tian, Libo Zou
Reports have showed that Sigma-1 receptor (Sig-1R) activation can protect neurons against cerebral ischemia/reperfusion (I/R) injury in mice and alleviate endoplasmic reticulum (ER) stress in cultured cells, but little known is about the protective role of Sig-1R on ER stress induced by cerebral I/R. The purpose of this study was to determine whether Sig-1R exerts a protective effect against ER stress-mediated apoptosis in cerebral I/R using a 15-min bilateral common carotid artery occlusion (BCCAO) mouse model...
November 1, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30357572/klotho-modulates-er-mediated-signaling-crosstalk-between-prosurvival-autophagy-and-apoptotic-cell-death-during-lps-challenge
#4
Jennifer Mytych, Przemyslaw Solek, Marek Koziorowski
Bacterial endotoxins have been shown to induce prosurvival autophagy or apoptosis in fibroblasts and thus impair the wound healing process. Endoplasmic reticulum has been proposed as a molecular switch between these processes and klotho protein possessing pleiotropic characteristics seems to be involved in both processes, however the exact molecular mechanism is unknown. In this study, we have evaluated the effect of klotho silencing on human fibroblasts exposed to a non-toxic dose of lipopolysaccharide in terms of in vitro wound healing ability...
October 24, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30288639/tak1-mediates-convergence-of-cellular-signals-for-death-and-survival
#5
REVIEW
Sabreena Aashaq, Asiya Batool, Khurshid I Andrabi
TGF-β activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been implicated in regulating diverse range of cellular processes that include embryonic development, differentiation, autophagy, apoptosis and cell survival. TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling pathways including the C-Jun N-terminal kinase (JNK), p38 MAPK, and I-kappa B kinase complex (IKK) involved in establishing cellular commitments for death and survival...
October 4, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30196356/molecular-targeting-of-breast-and-colon-cancer-cells-by-par1-mediated-apoptosis-through-a-novel-pro-apoptotic-peptide
#6
Tanusree Ray, Dwiprohi Kar, Ananda Pal, Shravanti Mukherjee, Chandrima Das, Amit Pal
A novel activating peptide was designed and synthesized from V. cholerae hemagglutinine protease (HAP) mediated cleavage site of mouse PAR1. The peptide "PFISED" interacts with PAR1 in a new site which is different from its thrombin mediated conventional activation site and induced a series of new downstream signaling pathways. The peptide showed apoptosis in human and mouse breast (MCF-7 and EAC) and colon (HT29 and CT26) cancer cells where as in the same peptide concentration in normal human breast epithelial cells (MCF-10A), normal human fibroblast cells (MRC-5), normal mouse peritoneal macrophage cells and normal mouse breast and colon tissues did not show any effect...
September 8, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30171376/n-3-oxo-acyl-homoserine-lactone-induced-germ-cell-apoptosis-and-suppressed-the-over-activated-ras-mapk-tumorigenesis-via-mitochondrial-dependent-ros-in-c-elegans
#7
Bin Chen, Xianbin Cao, Huayi Lu, Pengbo Wen, Xiaojing Qi, Shaopeng Chen, Lijun Wu, Chi Li, An Xu, Guoping Zhao
As a quorum-sensing molecule for bacteria-bacteria communication, N-(3-oxododecanoyl)-homoserine lactone (C12) has been found to possess pro-apoptotic activities in various cell culture models. However, the detailed mechanism of how this important signaling molecule function in the cells of live animals still remains largely unclear. In this study, we systematically investigated the mechanism for C12-mediated apoptosis and studied its anti-tumor effect in Caenorhabditis elegans (C. elegans). Our data demonstrated that C12 increased C...
August 31, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30293220/correction-to-release-of-overexpressed-cypb-activates-erk-signaling-through-cd147-binding-for-hepatoma-cell-resistance-to-oxidative-stress
#8
Kiyoon Kim, Hunsung Kim, Kwon Jeong, Min Hyung Jung, Bum-Soo Hahn, Kyung-Sik Yoon, Byung Kwan Jin, Geon-Ho Jahng, Insug Kang, Joohun Ha, Wonchae Choe
The original version of this article contained a mistake. The bands for HA Tag and t-ERK in Figs. 2d, 2h, 3d are incorrect. The author informs that these errors had no influence in the scientific content of the paper. The corrected figures (Figs. 2 and 3) are given below.
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30288638/ready-player-one-autophagy-shapes-resistance-to-photodynamic-therapy-in-cancers
#9
REVIEW
Xian Duan, Bo Chen, Yanan Cui, Lin Zhou, Chenkai Wu, Zhulin Yang, Yu Wen, Xiongying Miao, Qinglong Li, Li Xiong, Jun He
Photodynamic therapy (PDT) is a procedure used in cancer therapy that has been shown to be useful for certain indications. Considerable evidence suggests that PDT might be superior to conventional modalities for some indications. In this report, we examine the relationship between PDT responsiveness and autophagy, which can exert a cytoprotective effect. Autophagy is an essential physiological process that maintains cellular homeostasis by degrading dysfunctional or impaired cellular components and organelles via a lysosome-based pathway...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30284149/inhibition-of-the-ubiquitination-of-hsf1-by-fbxw7-protects-the-intestine-against-ischemia-reperfusion-injury
#10
Wenzhi Tan, Huanyu Zhao, Feng Zhang, Zhenlu Li, Dongcheng Feng, Yang Li, Wei Zhou, Liwei Liu, Jihong Yao, Xiaofeng Tian
Epithelial apoptosis is an important factor in intestinal ischemia-reperfusion (I/R) injury. Heat shock factor 1 (HSF1) is a classical stress response factor that directly regulates the transcription of heat shock proteins (HSPs) under stress conditions. Although HSPs are involved in protecting the intestine against I/R, the mechanism whereby HSF1 is regulated in I/R is poorly understood. Here, we show that the ubiquitin ligase FBXW7 targets HSF1 for ubiquitination and degradation in intestinal I/R. In this study, we found that FBXW7 expression was upregulated at the transcriptional level in intestinal mucosae subjected to I/R...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30267240/mechanisms-of-monocyte-cell-death-triggered-by-dengue-virus-infection
#11
REVIEW
Jorge Andrés Castillo, Silvio Urcuqui-Inchima
Arthropod-borne viral diseases caused by dengue virus (DENV) are major re-emerging public health problem worldwide. In spite of intense research, DENV pathogenesis is not fully understood and remains enigmatic; however, current evidence suggests that dengue progression is associated with an inflammatory response, mainly in patients suffering from a second DENV infection. Monocytes are one of the main target cells of DENV infection and play an important role in pathogenesis since they are known to produce several inflammatory cytokines that can lead to endothelial dysfunction and therefore vascular leak...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30259216/augmenter-of-liver-regeneration-promotes-mitochondrial-biogenesis-in-renal-ischemia-reperfusion-injury
#12
Li-Li Huang, Rui-Ting Long, Gui-Ping Jiang, Xiao Jiang, Hang Sun, Hui Guo, Xiao-Hui Liao
Mitochondria are the center of energy metabolism in the cell and the preferential target of various toxicants and ischemic injury. Renal ischemia-reperfusion (I/R) injury triggers proximal tubule injury and the mitochondria are believed to be the primary subcellular target of I/R injury. The promotion of mitochondrial biogenesis (MB) is critical for the prevention I/R injury. The results of our previous study showed that augmenter of liver regeneration (ALR) has anti-apoptotic and anti-oxidant functions. However, the modulatory mechanism of ALR remains unclear and warrants further investigation...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30238335/genetic-deficiency-of-the-tumor-suppressor-protein-p53-influences-erythrocyte-survival
#13
Rosi Bissinger, Elisabeth Lang, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Mehrdad Ghashghaeinia, Lisann Pelzl, Basma Sukkar, Abdulla Al Mamun Bhuyan, Madhuri S Salker, Yogesh Singh, Birgit Fehrenbacher, Hajar Fakhri, Anja T Umbach, Martin Schaller, Syed M Qadri, Florian Lang
The transcription factor p53 suppresses tumor growth by inducing nucleated cell apoptosis and cycle arrest. Because of its influence on primitive erythroid cell differentiation and survival, p53 is an important determinant of erythropoiesis. However, the impact of p53 on the fate of erythrocytes, cells lacking nucleus and mitochondria, during their post-maturation phase in the circulation remained elusive. Erythrocyte survival may be compromised by suicidal erythrocyte death or eryptosis, which is hallmarked by phosphatidylserine translocation and stimulated by increase of cytosolic Ca2+ concentration...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30232656/lncrna-135528-inhibits-tumor-progression-by-up-regulating-cxcl10-through-the-jak-stat-pathway
#14
Peng Wang, Xiaobin Peng, Jingjing Zhang, Zhen Wang, Jiaxue Meng, Bohong Cen, Aimin Ji, Shuai He
Spontaneous tumor regression can be observed in many tumors, however, studies related to the altered expression of lncRNA in spontaneous glioma regression are limited, and the potential contributions of lncRNAs to spontaneous glioma regression remain unknown. To investigate the biological roles of lncRNA-135528 in spontaneous glioma regression. The cDNA fragment of lncRNA-135528 was obtained by rapid-amplification of cDNA ends (RACE) technology and cloned into the plvx-mcmv-zsgreen-puro vector. Additionally, we stably silenced or overexpressed lncRNA-135528 in G422 cells by transfecting with siRNA against lncRNA-135528 or lncRNA-135528 overexpression plasmid...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30171377/targeting-autophagy-for-combating-chemoresistance-and-radioresistance-in-glioblastoma
#15
REVIEW
Matthew A Taylor, Bhaskar C Das, Swapan K Ray
Autophagy is an evolutionarily conserved catabolic process that plays an essential role in maintaining cellular homeostasis by degrading unneeded cell components. When exposed to hostile environments, such as hypoxia or nutrient starvation, cells hyperactivate autophagy in an effort to maintain their longevity. In densely packed solid tumors, such as glioblastoma, autophagy has been found to run rampant due to a lack of oxygen and nutrients. In recent years, targeting autophagy as a way to strengthen current glioblastoma treatment has shown promising results...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30167920/mirna-126-expression-inhibits-il-23r-mediated-tnf-%C3%AE-or-ifn-%C3%AE-production-in-fibroblast-like-synoviocytes-in-a-mice-model-of-collagen-induced-rheumatoid-arthritis
#16
Jie Gao, Ruina Kong, Xiaoli Zhou, Lianmei Ji, Ju Zhang, Dongbao Zhao
Both miR-126 and IL-23R affect rheumatoid arthritis (RA) procession. This study aimed to investigate the association of miR-126 and IL-23R and the possible modulation of miR-126 to RA pathogenesis. Serum, synovial tissue and synovial fluid were collected from patients with RA, and expression of miR-126, IL-23R, TNF-α and IFN-γ were detected. Fibroblast-like synoviocytes (FLS) was established using a collagen-induced arthritis mice model. The expression of miR-126 was manual intervened using pro-miR-126 and anti-miR-126 encoding lentivirus plasmids, or miR-126 agonists and corresponding negative controls...
December 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30203236/novel-1-4-dihydropyridine-induces-apoptosis-in-human-cancer-cells-through-overexpression-of-sirtuin1
#17
Debashri Manna, Rajabrata Bhuyan, Forid Saikh, Somnath Ghosh, Jayasri Basak, Rita Ghosh
1,4-Dihydropyridines (1,4-DHPs) are important as a class of heterocyclic compounds that exhibit wide range of biological actions. Many of its derivatives are already characterized as medicinally important drugs and used worldwide. In this study, we have screened some novel Hantzsch 1,4-DHP compounds using both in silico (QSAR and Pharmacophore) and in vitro (cytotoxic screening). 1,4-DHP showed selective cytotoxicity against five human cancerous cell lines; A375, A549, HeLa, HepG2 and SH-SY5Y but limited effect towards normal skin keratinocyte (HaCaT), lung fibroblast (WL-38) and healthy peripheral blood mononuclear cells...
October 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30159848/ppv-acting-via-the-jnk-pathway-represses-apoptosis-during-normal-development-of-drosophila-wing
#18
Chunli Chi, Liguo Wang, Wenwen Lan, Long Zhao, Ying Su
Apoptosis is one of the main fundamental biological processes required for development of multicellular organisms. Inappropriate regulation of apoptosis can lead to severe developmental abnormalities and diseases. Therefore, the control of apoptosis, not only for its activation but also for its inhibition, is critically important during development. In contrast to the extensive studies of apoptosis induction, its inhibitory mechanisms that are even more vital in certain populations of cells actually are very far from being well understood...
October 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30117075/the-role-of-autophagy-in-pulmonary-hypertension-a-double-edge-sword
#19
REVIEW
Rui Chen, Meiping Jiang, Bo Li, Wei Zhong, Zhongqun Wang, Wei Yuan, Jinchuan Yan
Autophagy is a recycling process that degrades damaged or unneeded cellular components for renewal. Accumulating evidence suggests that dysregulation of autophagy is involved in pulmonary hypertension (PH). PH is a progressive disease characterized by persistent proliferation of apoptosis-resistant pulmonary vascular cells. However, reports on the role of autophagy in the development of PH are often conflicting. In this review, we discuss recent development in the field with emphasis on pulmonary arterial endothelial cells, pulmonary smooth muscle cells, right ventricular myocyte, as well as pharmacological strategies targeting the autophagic signaling pathway...
October 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/30084053/mlkl-mediates-apoptosis-via-a-mutual-regulation-with-perk-eif2%C3%AE-pathway-in-response-to-reactive-oxygen-species-generation
#20
Wen-Xiang Cao, Ting Li, Zheng-Hai Tang, Le-Le Zhang, Zhao-Yu Wang, Xia Guo, Min-Xia Su, Xiuping Chen, Jin-Jian Lu
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a core effector of necroptosis, and its function in necroptosis is widely studied. However, the function of MLKL in apoptosis remains unclear. In the present study, the role of MLKL in chelerythrine (CHE)-promoted apoptosis was studied. A special band of MLKL (i.e., *MLKL) was observed after treatment with CHE. MLKL and *MLKL were accumulated in the nucleus upon treatment with CHE and MLKL silencing reversed the CHE-induced apoptosis. Blockade of CHE-triggered reactive oxygen species (ROS) generation or inhibition of CHE-activated protein kinase-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 α subunit (eIF2α) pathway reversed the apoptosis...
October 2018: Apoptosis: An International Journal on Programmed Cell Death
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