Kanako Hagihara, Kousuke Hosonaka, Shuhei Hoshino, Kazuki Iwata, Naoki Ogawa, Ryosuke Satoh, Teruaki Takasaki, Takuya Maeda, Reiko Sugiura
Calcineurin (CN) is a conserved Ca2+ -calmodulin activated protein phosphatase, which plays important roles in immune regulation, cardiac hypertrophy, and apoptosis in humans. In pathogenic fungi, CN is essential for stress survival, sexual development, and virulence. The immunosuppressant tacrolimus (FK506) is a specific inhibitor of CN in humans and fungi including nonpathogenic fission yeast. Although calcineurin inhibition by FK506 or CN deletion in fission yeast does not induce growth defects, treatment with some anti-fungal drugs such as micafungin and valproic acid, induced synthetic lethality with calcineurin inhibition...
2022: Biocontrol Science