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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/30030881/comparison-of-hepatic-arterial-infusion-chemotherapy-between-5-fu-based-continuous-infusion-chemotherapy-and-cddp-monotherapy-for-advanced-hepatocellular-carcinoma
#1
Tomokazu Kawaoka, Tomoki Kobayashi, Hiroshi Aikata, Shinsuke Uchikawa, Kazuki Ohya, Kenichiro Kodama, Yuno Nishida, Kana Daijo, Mitsutaka Osawa, Yuji Teraoka, Yuki Inagaki, Fumi Honda, Masahiro Hatooka, Kei Morio, Reona Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Yasutaka Baba, Kazuo Awai, Kazuaki Chayama
AIM: The aim of this study is to compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC between 5-FU based continuous infusion chemotherapy and CDDP monotherapy (CDDP group) in patients with advanced hepatocellular carcinoma (HCC). METHODS: Patients were grouped according to HAIC regimens (5-FU group, n=317/ CDDP group, n=66). A two-to-one match was created using propensity score analysis (5-FU group, n=102/CDDP group, n=51). After matching, response rate (RR) and adverse events as primary endpoints and survival, progression free survival (PFS) as secondary endpoints were analyzed...
July 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30030872/wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-predicts-early-occurrence-of-hepatocellular-carcinoma-after-svr-by-direct-acting-antivirals-for-hcv
#2
Yutaka Yasui, Masayuki Kurosaki, Yasuyuki Komiyama, Hitomi Takada, Nobuharu Tamaki, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Yohei Kubota, Mayu Higuchi, Kenta Takaura, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Jun Itakura, Nobuyuki Enomoto, Namiki Izumi
BACKGROUND: The aim of this study is to clarify the value of serum WFA+ -M2BP for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virological responses (SVR) by therapy with interferon-free, direct acting antivirals (DAAs). METHODS: This is a retrospective cohort study which includes 567 patients who underwent antiviral therapy with an interferon free DAAs regimen and achieved SVR. Serum WFA+ -M2BP was measured after SVR...
July 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30014566/clinical-application-of-magnetic-resonance-elastography-in-chronic-liver-disease
#3
REVIEW
Hayato Abe, Yutaka Midorikawa, Masahiro Okada, Tadatoshi Takayama
Recent evidence highlighted that the accurate assessment of liver fibrosis is important for evaluating the progression of chronic liver disease. During the past decade, many noninvasive methods have been developed to reduce the need for core-needle biopsy in fibrosis staging and to overcome its limitations such as invasiveness, high costs, low reproducibility, and poor patient consent. The diagnostic performance of magnetic resonance elastography (MRE) is promising for use in clinical practice to evaluate not only liver fibrosis, but also survival and major clinical endpoints such as liver decompensation, portal hypertension, development of hepatocellular carcinoma, and surgical outcomes...
July 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30006955/clinical-evaluation-of-a-novel-and-highly-sensitive-immunoassay-for-anti-hepatitis-b-core-antigen-using-a-fully-automated-immunochemical-analyzer
#4
Kyo Izumida, Atsushi Kaneko, Kazuya Takahashi, Shigeru Kusumoto, Tomoko Narita, Akiyoshi Takami, Shinsuke Iida, Katsumi Aoyagi, Yasuhito Tanaka
AIM: Recently, the measurement of hepatitis B surface antigen and anti-hepatitis B core antigen (HBcAb) and/or anti-hepatitis B surface antigen is recommended before various therapies to identify the patients at risk of HBV reactivation. However, a recent study reported that HBV reactivation occurred in HBcAb negative patients, indicating that it is challenging to identify patients with a history of HBV infection using conventional HBcAb reagent. We developed a highly sensitive HBcAb (HBcAb-HS) assay for reducing of the HBV reactivation risk...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30005446/the-ratio-between-estimated-glomerular-filtration-rates-egfr-of-creatinine-and-cystatin-c-predicts-overall-survival-in-patients-with-hepatocellular-carcinoma
#5
Yasuyuki Tamai, Motoh Iwasa, Yuya Kawasaki, Naohiko Yoshizawa, Suguru Ogura, Ryosuke Sugimoto, Akiko Eguchi, Norihiko Yamamoto, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystain C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. METHODS: First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30005445/crossover-study-in-hyperammonemia-patients-for-efficacy-safety-and-acceptability-of-a-new-lactulose-preparation-sk-1202-compared-to-approved-drug
#6
Hitoshi Yoshiji, Yoshiyasu Karino, Yoshiyuki Suzuki, Fumitaka Suzuki, Masakazu Uejima, Hiroshi Aikata, Kazuaki Chayama, Hisakazu Iwai, Eiji Suzuki, Hiromitsu Kumada
AIM: A novel jelly lactulose preparation (SK-1202) has been developed to improve compliance and reduce the elevation of blood glucose levels in diabetic patients. To compare the equivalence in the efficacy and safety of SK-1202 and an approved commercially available syrup preparation, we conducted a randomized multicenter crossover study in hyperammonemia patients with liver cirrhosis who were taking lactulose. METHODS: Forty-four patients were enrolled and took each preparation for two weeks...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29981262/suppression-of-hbsag-production-by-combination-therapy-with-nucleotide-analogues-and-interferon-in-children-with-genotype-c-hepatitis-b-virus-infection
#7
Hitoshi Tajiri, Tomoko Takano, Yasuhito Tanaka, Jun Murakami, Stephen Brooks
BACKGROUND: Sustained suppression of HBsAg production after interferon treatment was not reported for children with chronic hepatitis B and with genotype C infection that is prevalent in Asia. Among children with HBeAg-positive genotype C chronic hepatitis B, we compared the efficacy of combination therapy with nucleotide analogues and interferon alfa in 11 children with the historical 12 cases treated with interferon monotherapy. METHODS: Combination of lamivudine and conventional interferon alfa was introduced for the first three patients while entecavir and peginterferon for the latest eight...
July 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29974624/the-accuracy-of-noninvasive-scoring-systems-for-diagnosing-nonalcoholic-steatohepatitis-related-fibrosis-multi-center-validation-study
#8
Yoshito Itoh, Yuya Seko, Toshihide Shima, Tomoaki Nakajima, Kei Mizuno, Yusuke Kawamura, Norio Akuta, Kiyoaki Ito, Miwa Kawanaka, Akira Hiramatsu, Michiie Sakamoto, Kenichi Harada, Yoshihito Goto, Takeo Nakayama, Hiromitsu Kumada, Takeshi Okanoue
BACKGROUND: Hepatic fibrosis is the most important factor for estimating the prognosis of patients with nonalcoholic fatty liver disease (NAFLD). A novel non-invasive scoring system, the FM-fibro index, showed high accuracy in a pilot study. The purpose of this study was to validate the efficacy of the FM-fibro index in a multi-center cohort. METHODS: Among 18 institutions, we analyzed 400 Japanese patients with biopsy-proven NAFLD. We evaluated the accuracies of the FM-fibro index, CA-index, and ELF panel by area under the receiver operator characteristics curves (AUROC)...
July 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29956443/phenotypic-and-functional-characterization-of-tumor-derived-endothelial-cells-isolated-from-primary-human-hepatocellular-carcinoma
#9
Wenjing Zhao, Liping Yang, Xudong Chen, Hongyan Qian, Suqing Zhang, Yali Chen, Runhua Luo, Jingjing Shao, Huanliang Liu, Jianguo Chen
AIMS: Tumor endothelial cells (TECs) have been investigated via human tumor xenografts in mice models. In order to provide the pure human TECs for the updating of clinical anti-angiogenic cancer therapy, in the present study we established a protocol of purification of TEC derived from clinical hepatocellular carcinoma (HCC) and revealed the TEC features by in vitro and in vivo assays. METHODS: We isolated TECs from fresh surgical resections of HCC by magnetic-activated cell sorting and purified by flow cytometry sorting upon CD31 expression, referred to as ECDHCCs...
June 28, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29954046/beyond-serum-creatinine-which-tools-to-evaluate-renal-function-in-cirrhotic-patients
#10
REVIEW
Paul Carrier, Marilyne Debette-Gratien, Marie Essig, Véronique Loustaud-Ratti
In cirrhotic patients, a high serum creatinine value is an independent mortality factor. Similarly, it is predictive of renal insufficiency after liver transplantation, and chronic kidney disease in this situation, is also an independent mortality factor. A relevant evaluation of GFR is currently crucial, particularly in case of end-stage liver disease or liver transplant project, and is key for the decision of double liver-kidney transplantation. Serum creatinine or creatinine-based equations are the most used tools in clinical practice but they significantly overestimate renal function...
June 28, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29935004/miglitol-attenuates-non-alcoholic-steatohepatitis-in-diabetic-patients
#11
Michiharu Komatsu, Naoki Tanaka, Takefumi Kimura, Naoyuki Fujimori, Kenji Sano, Akira Horiuchi, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Eiji Tanaka
AIM: Post-prandial hyperglycemia is frequently accompanied by non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Although alpha-glucosidase inhibitors (αGIs) can slow glucose absorption from the intestine and suppress the surge of circulating glucose concentration after meals, it remains unclear whether αGIs are also beneficial for NASH. The aim of this prospective study was to examine the efficacy and safety of miglitol, a typical αGI, for NASH. METHODS: Seventeen patients with histologically-confirmed NASH and hemoglobin A1c (HbA1c) >6...
June 23, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29934990/factors-improving-the-utility-of-anti-viral-therapy-for-chronic-hepatitis-b-a-nationwide-multi-center-study-in-japan
#12
Yoko Yamagiwa, Naohiko Masaki
AIM: The consideration of patients' needs in terms of research outcomes is emphasized in research promotion to eradicate hepatitis B virus according to the Basic Act on Hepatitis Measures in Japan. This study analyzed patients' attitudes toward experienced anti-viral therapies for chronic hepatitis B and their need for future therapies. METHODS: A self-administered questionnaire comprising 124 questions was conducted among patients with chronic hepatitis B from 61 core-center hospitals designated to implement and research policies on hepatitis in 47 prefectures from August 2013 to January 2014 (N = 3021, response rate = 51%)...
June 22, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29934967/long-term-outcome-after-cholecystocolostomy-for-progressive-familial-intrahepatic-cholestasis
#13
Long Chen, Hui Xiao, Xiang-Hai Ren, Long Li
AIM: To evaluate the long-term efficacy of cholecystocolostomy surgery for Progressive Familial Intrahepatic Cholestasis (PFIC). METHODS: From August 2003 to November 2014, 34 clinically diagnosed children, including 11 Familial Intrahepatic Cholestasis-1 (FIC1) , 13 Bile Salt Export Pump (BSEP) disease and 5 cases with low γ-glutamyl transpeptidase (GGT) disease (levels < 100 U/L), 5 Multidrug Resistance Class III (MDR3) disease with high GGT disease (levels > 100 U/L), identified in our center...
June 22, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29924905/a-long-non-coding-rna-expression-profile-can-predict-early-recurrence-in-hepatocellular-carcinoma-after-curative-resection
#14
Yufeng Lv, Wenhao Wei, Zhong Huang, Zhichao Chen, Yuan Fang, Lili Pan, Xueqiong Han, Zihai Xu
PURPOSE: The aim of this study was to develop a novel long non-coding RNA (lncRNA) expression signature to accurately predict early recurrence for patients with hepatocellular carcinoma (HCC) after curative resection. PATIENTS AND METHODS: Using expression profiles downloaded from The Cancer Genome Atlas database, we identified multiple lncRNAs with differential expression between early recurrence (ER) group and non-early recurrence (non-ER) group of HCC. Least absolute shrinkage and selection operator (LASSO) for logistic regression models were used to develop a lncRNA-based classifier for predicting ER in the training set...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29923681/microbiome-and-bile-acid-profiles-in-duodenal-aspirates-from-cirrhotics-the-microbiome-microbial-markers-and-liver-disease-study
#15
Jonathan P Jacobs, Tien S Dong, Vatche Agopian, Venu Lagishetty, Vinay Sundaram, Mazen Noureddin, Walid Ayoub, Francisco Durazo, Jihane Benhammou, Pedram Enayati, David Elashoff, Marc T Goodman, Joseph Pisegna, Shehnaz Hussain
AIM: Cirrhosis is a leading cause of death in the world, yet there are no well-established risk stratifying tools for lethal complications including hepatocellular carcinoma (HCC). Patients with liver cirrhosis undergo routine endoscopic surveillance, providing ready access to duodenal aspirate samples which may be a source for identifying novel biomarkers. The aim of this study was to characterize the microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis to demonstrate feasibility of developing biomarkers for HCC risk stratification...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29923661/spermine-oxidase-is-up-regulated-and-promotes-tumor-growth-in-hepatocellular-carcinoma
#16
Tingting Hu, Dalong Sun, Jie Zhang, Ruyi Xue, Harry L A Janssen, Wenqing Tang, Ling Dong
AIM: The polyamine catabolic enzyme, spermine oxidase (SMOX) is up-regulated in chronic inflammatory conditions and linked to increased reactive oxygen species (ROS) and DNA damage in various forms of cancers. The present study aims to explore the expression pattern and biological function of SMOX in hepatocellular carcinoma (HCC). METHODS: We used qRT-PCR, Western blotting and immunohistochemistry to examine SMOX expression in four HCC cell lines and 120 cases of HCC clinical samples, and the clinical significance of SMOX was analyzed...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29908044/utilization-and-efficacy-of-elbasvir-grazoprevir-for-treating-hepatitis-c-virus-infection-after-liver-transplantation
#17
Satoshi Miuma, Hisamitsu Miyaaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Hidetaka Shibata, Naota Taura, Susumu Eguchi, Kazuhiko Nakao
AIM: Recently, elbasvir/grazoprevir combination therapy (EBR/GZR) was reported to have excellent antiviral effects for chronic genotype 1 hepatitis C virus (HCV) infection. However, it has not been recommended for patients with post-liver transplant (LT) HCV re-infections because of a lack of evidence for effectiveness and drug-drug interactions. METHODS: We report the usage of EBR/GZR in five post-LT HCV re-infected patients with the kinetics of renal function and tacrolimus trough levels during and after therapy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29908040/dual-energy-computed-tomography-for-non-invasive-staging-of-liver-fibrosis-accuracy-of-iodine-density-measurements-from-contrast-enhanced-data
#18
Keitaro Sofue, Masakatsu Tsurusaki, Achille Mileto, Tomoko Hyodo, Kosuke Sasaki, Tatsuya Nishii, Takaaki Chikugo, Norihisa Yada, Masatoshi Kudo, Kazuro Sugimura, Takamichi Murakami
AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy computed tomography (CT) data can non-invasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (non-contrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29882396/comparison-of-patients-with-hepatic-encephalopathy-and-those-with-gastric-varices-before-and-after-balloon-occluded-retrograde-transvenous-obliteration
#19
Tsuyoshi Ishikawa, Ryo Sasaki, Tatsuro Nishimura, Takashi Matsuda, Masaki Maeda, Takuya Iwamoto, Issei Saeki, Isao Hidaka, Taro Takami, Isao Sakaida
AIM: To compare the clinical characteristics of patients with hepatic encephalopathy (HE) and those with gastric varices (GV) before and after balloon-occluded retrograde transvenous obliteration (BRTO). METHODS: Eighty cirrhotic patients who underwent BRTO, including 42 men and 38 women, and whose mean age was 68 years, comprised the HE (n = 18) and GV (n = 62) groups. The patients' data before and 1 month after BRTO were analyzed. RESULTS: Before BRTO, the groups did not differ in their portal flow volume (PFV) or hepatic venous pressure gradient (HVPG)...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29882386/steroidogenesis-in-ovarian-like-mesenchymal-stroma-of-hepatic-and-pancreatic-mucinous-cystic-neoplasms
#20
Hiroyuki Kumata, Keigo Murakami, Kazuyuki Ishida, Shigehito Miyagi, Atsushi Arakawa, Yoshiaki Inayama, Keiichi Kinowaki, Atsushi Ochiai, Motohiro Kojima, Michiyo Higashi, Suzuko Moritani, Kyoko Kuwahara, Yukio Nakatani, Dai Kajiura, Gen Tamura, Hiroshi Kijima, Mitsunori Yamakawa, Taizo Shiraishi, Yukinori Inadome, Kazuhiro Murakami, Hiroyoshi Suzuki, Takashi Sawai, Michiaki Unno, Takashi Kamei, Hironobu Sasano
Aim Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. Mucinous cystic neoplasms are known to harbor ovarian-like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs. Methods Both steroid receptors and steroidogenic factors were immunohistochemically evaluated using H-scores and results were compared with those in 15 ovarian MCNs and 10 normal ovaries...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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