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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/28902450/current-status-of-portal-vein-thrombosis-in-japan-results-of-a-questionnaire-survey-by-the-japan-society-for-portal-hypertension
#1
Seiichiro Kojima, Norihito Watanabe, Jun Koizumi, Shigehiro Kokubu, Naoya Murashima, Shoichi Matsutani, Katsutoshi Obara
AIM: To investigate the current status of portal vein thrombosis (PVT) in Japan, the Clinical Research Committee of the Japan Society of Portal Hypertension conducted a questionnaire survey. METHODS: A questionnaire survey of 539 cases of PVT over the previous 10 years was conducted at institutions affiliated with the Board of Trustees of the Japan Society of Portal Hypertension. RESULTS: The most frequent underlying etiology of PVT was liver cirrhosis (LC) in 75...
September 13, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28895260/changes-of-serum-chitinase-3-like-1-levels-correlate-with-changes-of-liver-fibrosis-measured-by-the-two-established-quantitative-methods-in-chronic-hepatitis-b-patients-following-antiviral-therapy
#2
Lin Wang, Tianhui Liu, Jialing Zhou, Hong You, Jidong Jia
AIM: Non-invasive assessment for liver fibrosis change is still an unmet medical need in the era of antiviral therapy. Therefore, we explore whether the chitinase 3-like 1 (CHI3L1), a serum marker of liver fibrosis, can be used as a non-invasive surrogate marker to fibrosis change during treatment. METHODS: We correlated the serum CHI3L1 levels with liver tissue collagen proportionate area (CPA) in a cohort of 131 CHB patients receiving entecavir-based antiviral therapy for 78 weeks...
September 12, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28888081/study-of-the-sleep-quality-and-psychological-state-of-patients-with-hepatitis-b-liver-cirrhosis
#3
Guoqing Xiao, Qing Ye, Tao Han, Junqing Yan, Lixia Sun, Fengmei Wang
We aimed to investigate the sleep quality, mild hepatic encephalopathy, anxiety and depression in patients with hepatitis B cirrhosis by using a variety of scales and questionnaires. A cohort of 341 patients with hepatitis B liver cirrhosis were categorized by Child-Pugh grading (A, B, and C) in this cross-sectional study. Pittsburgh Sleep Quality Index (PSQI), Number Connection Test-A (NCT-A), and Hospital Anxiety and Depression (HAD) evaluated the questionnaires and statistically analyzed the intrinsic correlation...
September 9, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28884930/retreatment-with-sofosbuvir-ledipasvir-with-or-without-lead-in-interferon-%C3%AE-injections-in-patients-infected-with-genotype-1b-hcv-after-unsuccessful-daclatasvir-asunaprevir-therapy
#4
Hayato Uemura, Yoshihito Uchida, Jun-Ichi Kouyama, Kayoko Naiki, Shinpei Yamaba, Akira Fuchigami, Yoichi Saito, Keisuke Shiokawa, Yohei Fujii, Hiroshi Uchiya, Manabu Nakazawa, Satsuki Ando, Masamitsu Nakao, Daisuke Motoya, Kayoko Sugawara, Mie Inao, Yukinori Imai, Nobuaki Nakayama, Tomoaki Tomiya, Satoshi Mochida
AIMS: To improve the therapeutic efficacy of sofosbuvir/ledipasvir for the retreatment of patients after daclatasvir/asunaprevir, a customized therapy with or without lead-in interferon-β injections was performed according to the types of resistance-associated substitutions (RASs) in the NS5A region of genotype 1b HCV. METHODS: Thirty-three patients failing prior daclatasvir/asunaprevir received sofosbuvir/ledipasvir for 12 weeks. Patients with HCV carrying unfavorable NS5A-RASs and/or those with previous simeprevir administration were given lead-in interferon-β injections twice a day for 2 weeks; sequential changes in the NS5A-RASs during the injection period were evaluated using deep sequencing...
September 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28884879/analysis-of-hbsag-using-high-sensitivity-hbsag-assays-in-hepatitis-b-virus-carriers-in-whom-hbsag-seroclearance-was-confirmed-by-conventional-assays
#5
Itaru Ozeki, Tomoaki Nakajima, Hirokazu Suii, Ryoji Tatsumi, Masakatsu Yamaguchi, Mutsuumi Kimura, Tomohiro Arakawa, Yasuaki Kuwata, Takumi Ohmura, Shuhei Hige, Yoshiyasu Karino, Joji Toyota
AIM: We investigated the utility of high-sensitivity hepatitis B surface antigen (HBsAg) assays compared with conventional HBsAg assays. METHODS: Using serum samples from 114 hepatitis B virus (HBV) carriers in whom HBsAg seroclearance was confirmed by conventional HBsAg assays (cutoff value, 0.05 IU/mL), the amount of HBsAg was re-examined by high-sensitivity HBsAg assays (cutoff value, 0.005 IU/mL). Cases negative for HBsAg in both assays were defined as consistent cases, and cases positive for HBsAg in the high-sensitivity HBsAg assay only were defined as discrepant cases...
September 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28877392/prevalence-of-pruritus-in-patients-with-chronic-liver-disease-a-multicenter-study
#6
Satoshi Oeda, Hirokazu Takahashi, Hisako Yoshida, Yuji Ogawa, Kento Imajo, Masato Yoneda, Yuichi Koshiyama, Masafumi Ono, Hideyuki Hyogo, Takumi Kawaguchi, Hideki Fujii, Ken Nishino, Yoshio Sumida, Saiyu Tanaka, Miwa Kawanaka, Takuji Torimura, Toshiji Saibara, Atsushi Kawaguchi, Atsushi Nakajima, Yuichiro Eguchi
AIM: Pruritus is a common comorbidity in chronic liver disease. The aim of this study was to clarify the prevalence of pruritus and its characteristics in patients with chronic liver disease. METHODS: A total of 1,631 patients with chronic liver disease, who attended 9 joint-research facilities from January to June 2016 were enrolled. We investigated the prevalence of pruritus, itch location, itch duration, daily itch fluctuation, seasonal itch exacerbation, treatment drug, and therapeutic effect using a medical interview questionnaire...
September 6, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28872737/a-case-of-chronic-hepatitis-caused-by-hepatitis-c-virus-exhibiting-a-discrepancy-between-serogroup-and-genotype-because-of-inter-genotypic-2b-1b-recombination-a-pitfall-in-antiviral-therapy-with-direct-acting-antivirals
#7
Hayato Kurata, Yoshihito Uchida, Jun-Ichi Kouyama, Kayoko Naiki, Manabu Nakazawa, Satsuki Ando, Masamitsu Nakao, Daisuke Motoya, Kayoko Sugawara, Mie Inao, Yukinori Imai, Nobuaki Nakayama, Tomoaki Tomiya, Satoshi Mochida
A 40-year-old male patient with virologic relapse after daclatasvir plus asunaprevir therapy for a serogroup 1 HCV infection visited our hospital for retreatment. Virologic examinations revealed that a genotype 2b HCV strain carrying both NS3-S122N/D168A and NS5A-R30Q/L31M/Q54H/Y93H mutations had relapsed. The patient received sofosbuvir plus ribavirin therapy, but virologic relapse occurred once again. Sequencing of the HCV genome clarified an inter-genotypic recombination of 2b and 1b with an estimated crossover point between nt3,114 and nt3,115, corresponding to the N-terminal end of the NS3 region (DDBJ/EMBL/GenBank databases accession numbers LC273304)...
September 5, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28865403/cumulative-incidence-and-risk-factors-for-the-development-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-b-who-achieved-sustained-disappearance-of-viremia-by-nucleos-t-ide-analogue-treatment
#8
Yusuke Ando, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Kazuhiko Hayashi, Tetsuya Ishikawa, Isao Nakano, Yoshiki Hirooka, Hidemi Goto
AIM: Nucleos(t)ide analogue (NA) therapy has been reported to reduce the risk of hepatocellular carcinoma (HCC). However, some patients who achieve hepatitis B virus (HBV) DNA disappearance from serum by NA develop HCC. In this study, we investigated the cumulative incidence and risk factors for HCC in patients with chronic hepatitis B (CHB) who achieved sustained disappearance of viremia by NA treatment. METHODS: A total of 133 CHB patients [median age: 51 years; 79 males (59%); 28 with cirrhosis (21%)] who received NA and achieved HBV DNA disappearance from serum were analyzed retrospectively...
September 2, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28865095/are-donors-or-recipients-a-more-important-predictive-factor-for-the-development-of-non-alcoholic-fatty-liver-disease-after-liver-transplantation
#9
EDITORIAL
Masafumi Ono
No abstract text is available yet for this article.
September 1, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28841782/risk-of-malignancies-in-autoimmune-hepatitis-type-1-patients-with-a-long-term-follow-up-in-japan
#10
Teruko Arinaga-Hino, Tatsuya Ide, Ichiro Miyajima, Kei Ogata, Reiichiro Kuwahara, Keisuke Amano, Toshihiro Kawaguchi, Toru Nakamura, Takumi Kawaguchi, Hironori Koga, Koji Yonemoto, Takuji Torimura
BACKGROUNDS/AIMS: The risk of malignancies in autoimmune diseases is high and is regarded to be due to immunological abnormalities, the use of immunosuppressive agents, and/or chronic inflammation. The aim of this study was to investigate the incidence and risk of malignancies in patients with autoimmune hepatitis (AIH) type 1 in Japan. METHODS: Two hundred and fifty-six patients diagnosed with AIH were enrolled. A person-year calculation was performed for AIH patients, and the numbers of expected events were clarified using data from "The Monitoring of Cancer Incidence in Japan Project" in order to examine the standard incident rate (SIR) of each type of malignancy...
August 25, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28837746/hepatitis-c-virus-related-symptoms-but-not-quality-of-life-were-improved-by-treatment-with-direct-acting-antivirals
#11
Tatsuki Ichikawa, Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Yasuhide Motoyoshi, Hiroshi Akahoshi, Satomi Nakamura, Junpei Nakamura, Youichi Takahashi, Tetsurou Honda, Hiroyuki Yajima, Ryouhei Uehara, Naoyuki Hino, Syouhei Narita, Hisaya Tanaka, Seina Sasaki, Kazuhiko Nakao
BACKGROUND & AIMS: Direct acting-antivirals (DAAs) for treating hepatitis C virus (HCV) infection have a significant high sustained viral response rate after a short treatment course and do not have any severe adverse effects. Patient-reported outcomes (PROs) have become increasingly important to assess the total impact of a chronic disease. We aimed to evaluate the changes in symptoms of patients with HCV infection treated with DAA by using PROs. METHODS: A total of 107 patients with chronic HCV infection were treated with DAAs...
August 24, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28834607/association-of-baseline-vitamin-d-level-with-genetic-determinants-and-virologic-response-in-patients-with-chronic-hepatitis-b
#12
Rui Yu, Deming Tan, Qin Ning, Junqi Niu, Xuefan Bai, Shijun Chen, Jun Cheng, Yanyan Yu, Hao Wang, Min Xu, Guangfeng Shi, Mobin Wan, Xinyue Chen, Hong Tang, Jifang Sheng, Xiaoguang Dou, Junping Shi, Hong Ren, Maorong Wang, Hongfei Zhang, Zhiliang Gao, Chengwei Chen, Hong Ma, Jidong Jia, Jinlin Hou, Qing Xie, Jian Sun
AIM: The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week-104 treatment outcome in CHB patients. METHODS: Baseline serum 25-hydroxycholecalciferol [25(OH)D] levels and genetic polymorphism within GC, DHCR7 and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed the 104-week telbivudine monotherapy or telbivudine-based optimized therapy...
August 23, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28833919/il-10-secreted-by-mesenchymal-stem-cells-attenuates-acute-liver-failure-through-inhibiting-pyroptosis
#13
Wang Jinglin, Ren Haozhen, Yuan Xianwen, Ma Hucheng, Shi Xiaolei, Ding Yitao
AIMS: Recently, the benefit of mesenchymal stem cells (MSCs) as a cell-based therapy for acute liver failure (ALF) has gained much attention, although the mechanism of action of MSCs in the treatment of ALF remains elusive. Pyroptosis is a novel form of programmed cell death with an intense inflammatory response. The aim of the present study was to explore the soluble cytokines secreted by MSCs and their therapeutic effects via inhibiting pyroptosis in ALF. METHODS: MSCs obtained from C57BL/6 mice were isolated and cultured according to an established protocol...
August 22, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28834042/changes-in-serum-lipid-profiles-caused-by-three-regimens-of-interferon-free-direct-acting-antivirals-for-patients-infected-with-hepatitis-c-virus
#14
Takako Inoue, Takaaki Goto, Etsuko Iio, Kayoko Matsunami, Kei Fujiwara, Noboru Shinkai, Kentaro Matsuura, Takeshi Matsui, Shunsuke Nojiri, Yasuhito Tanaka
AIM: As described previously, serum low-density lipoprotein cholesterol (LDL-C) increases during treatment of chronic hepatitis C (CHC) with interferon-free direct-acting antivirals (DAAs). We sought to compare the changes of serum lipid profiles caused by three regimens. METHODS: A total of 216 CHC patients were enrolled. Among 170 patients infected with HCV genotype 1b, 85 received daclatasvir plus asunaprevir (DCV/ASV) and 85 received sofosbuvir plus ledipasvir (SOF/LDV)...
August 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28834004/elevated-serum-uric-acid-level-was-a-notable-adverse-event-during-combination-therapy-with-sofosbuvir-and-ribavirin
#15
Ken Sato, Atsushi Naganuma, Tamon Nagashima, Takashi Hoshino, Daisuke Uehara, Yousuke Arai, Katsuhiko Horiuchi, Kazuhisa Yuasa, Hisashi Takayama, Hirotaka Arai, Takeshi Hatanaka, Tatsuya Ohyama, Hiroki Tahara, Naondo Sohara, Takeshi Kobayashi, Norio Horiguchi, Yuichi Yamazaki, Satoru Kakizaki, Motoyasu Kusano, Masanobu Yamada, Takayo Murase, Takashi Nakamura
AIM: Combination therapy with sofosbuvir and ribavirin (SOF/RBV) has been recently available for chronic hepatitis C patients with genotype 2 (CHG2) in Japan. The domestic phase-III clinical trial showed a high antiviral effect with a relatively safe adverse event (AE) profile. Our aim was to report an important AE detected during treatment. METHODS: A prospective multi-institutional study of 12-week combination therapy with SOF/RBV for CHG2 was performed to evaluate efficacy and safety...
August 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28834072/a-severely-cholestatic-liver-graft-can-be-successfully-used-in-deceased-donor-liver-transplantation
#16
Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Toshihiro Kitajima, Rie Irie, Akinari Fukuda, Takako Yoshioka, Mureo Kasahara
The shortage of deceased organs is still a serious issue in Japan. A proactive approach to using liver grafts from extended criteria donors (ECDs) may be one way of expanding the donor pool; however, if it is recklessly attempted, a recipient receiving such a marginal graft can be at risk of mortality due to the primary non-function or a delayed graft function. We herein report the successful outcome of a recipient receiving a severely cholestatic graft that was considered transplantable because it lacked features characteristic of a long duration of "cholestasis" according to the precise interpretation of a donor biopsy...
August 18, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28796412/clinical-significance-of-half-lives-of-the-tumor-markers-alpha-fetoprotein-and-des-%C3%AE-carboxy-prothrombin-after-hepatectomy-for-hepatocellular-carcinoma
#17
Masayo Tsukamoto, Hidetoshi Nitta, Katsunori Imai, Takaaki Higashi, Nakagawa Shigeki, Hirohisa Okabe, Kota Arima, Takayoshi Kaida, Katsunobu Taki, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba
AIM: The prognostic significance of the half-lives (HLs) of alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) is unclear. We evaluated the HLs of AFP and DCP in a cohort of such patients. METHODS: This study included data on 202 patients with HCC who underwent curative hepatectomy and had preoperative AFP concentrations ≥ 100 ng/mL or DCP ≥ 200 mAU/mL. We calculated the HLs of AFP and DCP from their values just before and one month after hepatectomy...
August 10, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28795466/reduced-prevalence-of-hepatitis-b-surface-antigen-positivity-among-pregnant-women-born-after-the-national-implementation-of-immunoprophylaxis-for-babies-born-to-hepatitis-b-virus-carrier-mothers-in-japan
#18
Aya Sugiyama, Masayuki Ohisa, Shintaro Nagashima, Chikako Yamamoto, Chuon Channarena, Toshiko Fujii, Tomoyuki Akita, Keiko Katayama, Yoshiki Kudo, Junko Tanaka
AIM: We aimed to estimate hepatitis B surface antigen (HBsAg) positivity among birth year-stratified pregnant women in Hiroshima, Japan, and compare prevalence rates among women between born before and after implementation of a national immunoprophylactic vaccination program for babies born to hepatitis B virus (HBV) carrier mothers in Japan. METHODS: Pregnant women who gave birth at all delivery hospitals/clinics in Hiroshima prefecture between April 1, 2010 and March 31, 2011 were eligible...
August 9, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28753243/a-sero-epidemiological-survey-of-the-effect-of-hepatitis-b-vaccine-and-hepatitis-b-and-c-virus-infections-among-elementary-school-students-in-siem-reap-province-cambodia
#19
Mayumi Fujimoto, Channarena Chuon, Shintaro Nagashima, Chikako Yamamoto, Ko Ko, Sonama Svay, Sirany Hok, Olline Lim, Masayuki Ohisa, Tomoyuki Akita, Keiko Katayama, Junko Matsuo, Kazuaki Takahashi, Junko Tanaka
AIM: This study aimed to survey the prevalence and incidence of hepatitis B (HBV) and hepatitis C virus (HCV) infection among elementary school students in Siem Reap province, Cambodia and to evaluate the effects of a national infant HBV vaccination program introduced in 2001. METHODS: The 3(rd) grade students during 2011, 2012 and 2013 Academic years were enrolled in this study and they became 5(th) or 6(th) grade students in 2014-2015 Academic year at their second time examination...
July 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28722780/add-on-effects-of-fluvastatin-in-simeprevir-pegylated-interferon-ribavirin-combination-therapy-for-patients-with-genotype-1-hepatitis-c-virus-infection-a-randomized-controlled-study
#20
Goki Suda, Jun Ito, Atsushi Nagasaka, Yoshiya Yamamoto, Ken Furuya, Munenori Okamoto, Katsumi Terashita, Tomoe Kobayashi, Izumi Tsunematsu, Junichi Yoshida, Takashi Meguro, Masatsugu Ohara, Naoki Kawagishi, Megumi Kimura, Machiko Umemura, Takaaki Izumi, Yoko Tsukuda, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
BACKGROUND: The Japan Society of Hepatology guidelines indicate that HCV protease inhibitor combination therapy with simeprevir (SMV), pegylated-interferon (Peg-IFN), and ribavirin (RBV) is a therapeutic option for patients who fail to respond to a direct direct-acting antiviral (DAA) containing regimen. However, treatment outcomes have room for improvement. Fluvastatin (FLV) add-on treatment in Peg-IFN and RBV combination therapy for hepatitis C-infected patients significantly improved the sustained virological response (SVR), but the add-on effect of FLV on SMV combination therapy is not well understood...
July 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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