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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/30419152/non-invasive-liver-fibrosis-assessment-correlates-with-collagen-and-elastic-fiber-quantity-in-patients-with-hepatitis-c
#1
Yutaka Yasui, Tokiya Abe, Masayuki Kurosaki, Kotaro Matsunaga, Mayu Higuchi, Nobuharu Tamaki, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Kenta Takaura, Yohei Masugi, Hiroyuki Nakanishi, Kaoru Tsuchiya, Yuka Takahashi, Jun Itakura, Urara Sakurai, Akinori Hashiguchi, Michiie Sakamoto, Namiki Izumi
BACKGROUND AND AIMS: Elastic fiber deposition is a cause of irreversibility of liver fibrosis. However, to date, its relevance to clinical features has not yet been clarified. This study aimed to clarify the correlation between non-invasive markers of fibrosis and fiber quantity, including elastic fiber, obtained from computational analysis. METHODS: This retrospective study included 270 patients evaluated by non-invasive liver fibrosis assessment prior to liver biopsy...
November 12, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30403431/serosal-invasion-is-a-strong-prognostic-factor-for-hepatocellular-carcinoma-after-hepatectomy
#2
Katsunori Sakamoto, Kohei Ogawa, Taiji Tohyama, Yoshitomo Ueno, Kei Tamura, Hitoshi Inoue, Taro Nakamura, Jota Watanabe, Akihiro Takai, Yasutsugu Takada
AIM: The clinical impact of serosal invasion by hepatocellular carcinoma (HCC) remains unclear. This study aimed to clarify the significance of serosal invasion as a prognostic factor for patients who underwent hepatectomy for HCC. METHODS: This retrospective study investigated patients who underwent hepatectomy for HCC between 2003 October and 2016 September in Ehime University Hospital. A total of 161 cases were enrolled after excluding cases of concomitant distant metastasis, macroscopic tumor remnant, mixed HCC, and re-hepatectomy...
November 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30379383/differential-expression-of-circular-rnas-in-hepatic-tissue-in-a-model-of-liver-fibrosis-and-functional-analysis-of-theirtarget-genes
#3
Yuping Zhou, Xueyou Lv, Hui Qu, Kekai Zhao, Liyun Fu, Linwen Zhu, Guoliang Ye, Junming Guo
OBJECTIVE: To measure the expression profile of circular RNA (circRNA) in hepatic tissues in a liver fibrosis model and to explore their function via molecular biology and bioinformatic techniques. METHODS: The classic CCl4 mouse liver fibrosis model was established alongside a normal control group. The circRNA expression profile of hepatic tissue from the two groups was compared usinga high-throughput circRNA microarray. The differentially expressed circRNAs were identified, and RT-qPCR was used to verify a subsetof the differentially expressed circRNAs (target genes)...
October 31, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30375711/hepatitis-c-virus-infection-could-affect-the-pathogenesis-of-ischemic-heart-diseases-in-northern-part-of-japan
#4
Ryo Fukuda, Yasuteru Kondo
AIMS: Previously, our group reported that lymphotropic hepatitis C virus (HCV) could induce various kinds of immune-dysfunctions. The immune-dysfunctions could cause vascular disease by inducing cryoglobulinemia. It has been reported that ischemic heart diseases might be caused by HCV. However, the infectious rate of HCV in ischemic heart diseases has not been clarified in the northern part of Japan. Therefore, we tried to determine HCV infectivity precisely in patients with ischemic heart diseases...
October 30, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30367534/epidemiological-survey-of-hemoglobin-a1c-and-liver-fibrosis-in-a-general-population-with-non-alcoholic-fatty-liver-disease
#5
Kenichi Tanaka, Hirokazu Takahashi, Hideyuki Hyogo, Masafumi Ono, Noriko Oza, Yoichiro Kitajima, Miwa Kawanaka, Kazuaki Chayama, Toshiji Saibara, Keizo Anzai, Yuichiro Eguchi
AIM: The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the fibrosis-4 (FIB-4) index in a large general population cohort that underwent a health checkup. METHODS: A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non-alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB-4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level...
October 27, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30365236/combining-probiotics-and-an-angiotensin-ii-type-1-receptor-blocker-has-beneficial-effects-on-hepatic-fibrogenesis-in-a-rat-model-of-nonalcoholic-steatohepatitis
#6
Yasuhiko Sawada, Hideto Kawaratani, Takuya Kubo, Yukihisa Fujinaga, Masanori Furukawa, Soichiro Saikawa, Shinya Sato, Kenichiro Seki, Hiroaki Takaya, Yasushi Okura, Kosuke Kaji, Naotaka Shimozato, Tsuyoshi Mashitani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro, Junichi Yamao, Hitoshi Yoshiji
AIM: Intestinal endotoxin is important for the progression of nonalcoholic steatohepatitis (NASH). Circulating endotoxin levels are elevated in most animal models of diet-induced nonalcoholic fatty liver disease (NAFLD) and NASH. Further, plasma endotoxin levels are significantly higher in NAFLD patients, which is associated with small intestinal bacterial overgrowth and increased intestinal permeability. By improving the gut microbiota environment and restoring gut-barrier functions, probiotics are effective for NASH treatment in animal models...
October 26, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30358037/relationship-between-various-hepatic-function-scores-and-the-formation-of-esophageal-varices-in-patients-with-hiv-hcv-coinfection-due-to-contaminated-blood-products-for-hemophilia
#7
Tomoko Yoshimoto, Susumu Eguchi, Koji Natsuda, Masaaki Hidaka, Tomohiko Adachi, Shinichiro Ono, Takashi Hamada, Yu Huang, Kengo Kanetaka, Mitsuhisa Takatsuki
BACKGROUND: It was reported to be difficult to accurately assess the liver reserve capacity of patients with HIV/HCV coinfection through contaminated blood products by the Child-Pugh (CP) classification. Therefore, we investigated a clinically applicable scoring system in determining the risk of esophageal varices in HIV/HCV coinfected patients, that is known as latent portal hypertension leading to esophageal varices. PATIENTS AND METHODS: Forty-three patients with HIV/HCV coinfection underwent clinical examinations, including endoscopy and assessment of hepatic reserve, in our department between 2009 and 2017...
October 25, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30358027/a-proposed-model-for-the-prediction-of-intrahepatic-covalently-closed-circular-dna-level-in-patients-with-chronic-hepatitis-b
#8
Kunihiro Hasegawa, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Nobuhiro Aizawa, Ryo Takata, Kazunori Yoh, Noriko Ishii, Yukihisa Yuri, Takashi Nishimura, Hiroko Iijima, Etsuro Hatano, Jiro Fujimoto, Shuhei Nishiguchi
BACKGROUND: We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH-cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy. METHODS: Patients who did not receive previous nucleoside analogue (NA) therapy were assigned to the training cohort (n=57), and those who received previous NA therapy were assigned to the validation cohort (n=69). Factors linked to IH-cccDNA levels in the training cohort were analyzed and a formula to predict IH-cccDNA level was constructed...
October 25, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30350374/hbv-patients-with-low-hbsag-and-high-hbcrag-titers-have-a-high-risk-of-hbv-related-hcc
#9
Yuichiro Suzuki, Shinya Maekawa, Nobutoshi Komatsu, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Shuya Matsuda, Masaru Muraoka, Natsuko Nakakuki, Hiroko Shindo, Fumitake Amemiya, Shinichi Takano, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Tadashi Sato, Minoru Sakamoto, Atsuya Yamashita, Kohji Moriishi, Nobuyuki Enomoto
BACKGROUND AND AIM: Although the viral markers HBsAg and HBcrAg may reflect intrahepatic hepatitis B virus (HBV) replication activity and may constitute important biomarkers for hepatocellular carcinoma (HCC), the value of using these two markers in combination for assessing the HCC risk has not been clarified in detail until now. PATIENTS AND METHODS: Four hundred and forty-nine consecutive patients with chronic HBV infection were included in the study and the association of HBsAg and HBcrAg with the HCC risk was investigated cross-sectionally, as well as longitudinally...
October 22, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30347506/improved-survival-of-splenectomy-combined-with-curative-treatments-for-hepatocellular-carcinoma-in-child-b-patients-a-propensity-score-matching-study
#10
Youliang Pei, Zhanguo Zhang, Abdoul-Aziz Mba'nbo-Koumpa, Xiaoping Chen, Wanguang Zhang
AIMS: To explore the benefits of curative treatments (liver resection or local ablation) combined with splenectomy for patients with hepatocellular carcinoma (HCC) and Child grade B liver function. METHODS: We reviewed 245 patients with Child grade B liver function underwent curative intents for HCC. Among these patients, 116 patients performed curative treatments combined with splenectomy (the splenectomy group); the other 129 patients just underwent curative treatments (the non-splenectomy group)...
October 22, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30338893/stevia-prevents-experimental-cirrhosis-by-reducing-hepatic-myofibroblasts-and-modulating-molecular-profibrotic-pathways
#11
Erika Ramos-Tovar, Laura D Buendia-Montaño, Silvia Galindo-Gómez, Erika Hernández-Aquino, Víctor Tsutsumi, Pablo Muriel
AIM: The aims of the present study were to investigate the capacity of stevia leaves to prevent experimental cirrhosis induced by chronic administration of carbon tetrachloride (CCl4 ) in rats and to explore the action mechanism involved. METHODS: Liver cirrhosis was established by CCl4 administration (400 mg/kg by i.p. 3 times a week for 12 weeks); stevia powder was administered (100 mg/kg by gavage daily) during the CCl4 treatment. Serum markers of liver damage and hydroxyproline were evaluated and histopathological analyses were performed...
October 19, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30335208/predictors-of-hepatocellular-carcinoma-occurrence-after-direct-acting-antiviral-therapy-in-patients-with-hcv-infection
#12
Takao Watanabe, Yoshio Tokumoto, Kouji Joko, Kojiro Michitaka, Norio Horiike, Yoshinori Tanaka, Fujimasa Tada, Yoshiyasu Kisaka, Seiji Nakanishi, Kazuhiko Yamauchi, Atsushi Yukimoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa
AIM: The predictors for the development of hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) treatment were investigated. METHODS: A total of 1174 patients with chronic HCV infection were treated with DAA therapy (sofosbuvir and ledipasvir [n=615], sofosbuvir and ribavirin [n=380], and daclatasvir and asunaprevir [n=179]) and achieved sustained virological response (SVR). The HCC development rate and the factors that might contribute to the development of HCC after the end of DAA treatment were analyzed...
October 18, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30308081/recent-advances-in-medical-management-of-hepatocellular-carcinoma
#13
REVIEW
Kenji Ikeda
Transcatheter arterial therapies for hepatocellular carcinoma (HCC) have developed during last decade. Fine powder formulation of cisplatin and new platinum agent miriplatin became standard medicines in addition to anthracyclines on transcatheter arterial chemoembolization (TACE) in Japan. Recent prospective and retrospective studies supported the usefulness of platinum agents as a chemotherapeutic at the time of varied TACE therapy. Although balloon-occluded TACE is an effective manner of therapy for localized HCC and drug-eluting microspheres seemed to show a higher response rate in certain HCCs, definite advantages of those procedures still remained uncertain...
October 11, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30307682/efficacy-of-direct-acting-antiviral-treatment-in-patients-with-compensated-liver-cirrhosis-a-multicenter-study
#14
Norio Itokawa, Masanori Atsukawa, Akihito Tsubota, Tadashi Ikegami, Noritomo Shimada, Keizo Kato, Hiroshi Abe, Tomomi Okubo, Taeang Arai, Ai-Nakagawa Iwashita, Chisa Kondo, Shigeru Mikami, Toru Asano, Yasushi Matsuzaki, Hidenori Toyoda, Takashi Kumada, Etsuko Iio, Yasuhito Tanaka, Katsuhiko Iwakiri
AIM: Although the development of new direct-acting antivirals (DAA) for the treatment of chronic hepatitis C virus (HCV) infection has markedly advanced, how cirrhosis affects DAA treatment remains unclear. We aimed to clarify the impact of cirrhosis on DAA treatment of patients infected with HCV. METHODS: This large-scale, multicenter, retrospective study consisted of 2,130 HCV genotype 1b-infected patients who were treated with one of the following DAA combination therapies: asunaprevir/daclatasvir (ASV/DCV), ledipasvir/sofosbuvir (LDV/SOF) or paritaprevir/ombitasvir/ritonavir (PTV/OBV/r)...
October 11, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30277295/no-touch-ablation-in-hcc-has-the-potential-to-prevent-intrasubsegmental-recurrence-to-the-same-degree-as-surgical-resection
#15
Yusuke Kawamura, Kenji Ikeda, Junichi Shindoh, Yuta Kobayashi, Kayoko Kasuya, Shunichiro Fujiyama, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Masaji Hashimoto, Hiromitsu Kumada
BACKGROUND & AIMS: The aim of this study was to clarify the utility of a no-touch pincer ablation procedure that uses bipolar electrodes to prevent intrasubsegmental tumor recurrence after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC) compared to surgical resection. METHODS: We evaluated 175 consecutive patients with HCC (single nodule, tumor diameter ≤30 mm) who underwent surgical resection (146 received partial resection) and 313 patients who received RFA; 277 patients received touch ablation using a monopolar or bipolar RFA device, and 36 received no-touch ablation using a bipolar RFA device...
October 2, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30277289/high-recovery-rate-of-consciousness-by-high-volume-filtrate-hemodiafiltration-for-fulminant-hepatitis
#16
Keiichi Fujiwara, Ryuzo Abe, Shin Yasui, Osamu Yokosuka, Naoya Kato, Shigeto Oda
AIM: Artificial liver support (ALS) system sustaining patients with acute liver failure (ALF) in good condition until recovery of the native liver or performance of liver transplantation (LT), is essential for the improvement of the poor prognosis of ALF despite the lack of survival benefit. We aimed to investigate the efficacy of various ALS systems for fulminant hepatitis (FH) performed in our liver unit so far, focusing on the restoration of consciousness from hepatic encephalopathy...
October 2, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30248213/dysbalanced-sex-hormone-status-is-an-independent-predictor-of-decompensation-and-mortality-in-patients-with-liver-cirrhosis
#17
Rafael Paternostro, Birgit B Heinisch, Thomas Reiberger, Mattias Mandorfer, Constanze Bardach, Katharina Lampichler, Berit Seeland, Remy Schwarzer, Michael Trauner, Markus Peck-Radosavljevic, Arnulf Ferlitsch
AIMS: Endocrinological abnormalities, including low testosterone levels, are prevalent in cirrhosis. We assessed sexual hormone status in regard to hemodynamic abnormalities and its impact on hepatic decompensation and survival. METHODS: Males with cirrhosis were prospectively included in this study since 2010. Sexual hormones including bioavailable testosterone, total testosterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex hormone-binding globulin as well as Child-Pugh score, Model for End-stage Liver Disease (MELD) score, and hepatic venous pressure gradient were recorded...
September 24, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30248210/prompt-initiation-of-high-dose-intravenous-corticosteroids-seems-to-prevent-progression-to-liver-failure-in-patients-with-original-acute-severe-autoimmune-hepatitis
#18
Kalliopi Zachou, Pinelopi Arvaniti, Kalliopi Azariadis, Vasiliki Lygoura, Nikolaos K Gatselis, Aggeliki Lyberopoulou, George K Koukoulis, George N Dalekos
AIMS: Original acute-severe autoimmune hepatitis (AS-AIH) definition is unclear. However, its rapid recognition and early treatment is potentially life-saving. Therefore, we present herein an open, real-world observational study for the assessment of efficacy and safety of early high-dose intravenous corticosteroids in original AS-AIH patients. METHODS: Prospectively collected data from 184 AIH patients analysed retrospectively. Original AS-AIH defined as an acute-symptomatic presentation of newly-diagnosed AIH (transaminases>10xULN, bilirubin>4 mg/dl, INR≥1...
September 24, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30246902/prognostic-utility-of-novel-biomarkers-in-acute-on-chronic-liver-failure-aclf-associated-with-hepatitis-b-a-multicenter-prospective-study
#19
Ruihong Zhao, Wei Wu, Zhibo Zhou, Xiaoqing Zheng, Wenjie Sun, Yemin Shi, Haiying Yu, Fang Wang, Hong Zhao, Shanshan Sun, Linfeng Jin, Jifang Sheng, Yu Shi
BACKGROUND: Flare-ups of chronic hepatitis B (CHB) can sometimes be severe and even progress to acute-on-chronic liver failure (ACLF), with high short-term mortality. A timely estimation of the risk of death should be initiated early. The aim of the present study was to determine whether novel biomarkers add prognostic information beyond current clinical scoring systems. METHODS: Patients with HB-ACLF were prospectively enrolled from five hospitals between August 2017 and March 2018...
September 24, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/30238570/epigenetic-dysregulation-in-hepatocellular-carcinoma-an-up-to-date-review
#20
REVIEW
Masato Nakamura, Tetsuhiro Chiba, Kengo Kanayama, Hiroaki Kanzaki, Tomoko Saito, Yuko Kusakabe, Naoya Kato
Due to the advances made in research based on next generation sequencers, it is now possible to detect and analyze epigenetic abnormalities associated with cancer. DNA methylation, various histone modifications, chromatin remodeling, and non-coding RNA associated gene silencing are considered to be transcriptional regulatory mechanisms associated with gene expression changes. The breakdown of this precise regulatory system is involved in the transition to cancer. The important role of epigenetic regulation can be observed from the high rate of genetic mutations and abnormal gene expression leading to a breakdown in epigenetic gene expression regulation seen in hepatocellular carcinoma (HCC)...
September 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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