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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/29766631/pathological-findings-that-contribute-to-tissue-stiffness-in-the-spleen-of-liver-cirrhosis-patients
#1
Reiichiro Kondo, Masayoshi Kage, Hiroko Iijima, Jiro Fujimoto, Takashi Nishimura, Nobuhiro Aizawa, Jun Akiba, Yoshiki Naito, Hironori Kusano, Masamichi Nakayama, Yutaro Mihara, Masahiko Tanigawa, Hirohisa Yano
AIM: Spleen stiffness is increased in liver cirrhosis (LC). We attempted to characterize the pathological features of spleen in LC. METHODS: We compared pathological findings of resected spleen tissues of 28 LC patients and those of 6 healthy controls. In addition, we measured spleen stiffness before splenectomy by shearwave elastography in 9 LC patients. After splenectomy, we examined relationship between the spleen stiffness and its pathological findings. RESULTS: Passive congestion of the spleen was more frequently observed in the LC patients than in the controls (P < 0...
May 15, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29761604/remaining-hepatocellular-carcinoma-risk-in-chronic-hepatitis-b-patients-receiving-entecavir-tenofovir-in-south-korea
#2
Jung Hwan Yu, Young-Joo Jin, Jin-Woo Lee, Don-Haeng Lee
BACKGROUND/AIM: We aimed to identify the incidence rate of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with entecavir or tenofovir in South Korea, and to identify predictors of HCC development in these patients. METHODS: Between January, 2007 and December, 2015, 582 CHB patients initially received entecavir (n=406, 69.8%) or tenofovir (n=176, 30.2%) for CHB. RESULTS: During a median follow-up of 57.1 months, HCC developed in 38 (6...
May 14, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29737040/marked-accumulation-of-fdg-and-inflammatory-cells-expressing-glucose-transporter-3-in-igg4-related-autoimmune-hepatitis
#3
Toshihiro Araki, Teruko Arinaga-Hino, Hironori Koga, Jun Akiba, Tatsuya Ide, Yoshinobu Okabe, Reiichiro Kuwahara, Keisuke Amano, Makiko Yasumoto, Toshihiro Kawaguchi, Tomoya Sano, Reiichiro Kondou, Seiji Kurata, Keiichi Mitsuyama, Takuji Torimura
Immunoglobulin G (IgG) 4 related-autoimmune hepatitis (AIH) is a recently proposed subtype that responds well to steroid treatment; however, its pathogenesis remains unclear. We report here a 65-year-old Japanese female with skin itching and lip swelling. She had liver injury with jaundice, which persisted despite stopping of anti-allergic agents. Blood chemistry revealed highly elevated serum IgG and IgG4 (535 mg/dL) levels, and positive anti-nuclear antibody. The diagnosis of AIH was based on liver biopsy...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29736951/factors-associated-with-advanced-hepatic-fibrosis-in-patients-with-various-internal-diseases-a-multicenter-community-based-survey
#4
Takumi Kawaguchi, Tetsuaki Inokuchi, Tomoki Honma, Satoshi Itano, Eiji Kawasaki, Chizuko Inada, Toshichika Aoki, Naohira Tsumura, Akiteru Araki, Tokunori Mukae, Takuji Torimura
BACKGROUND AND AIMS: Advanced hepatic fibrosis can occur in patients with various diseases, including diabetes mellitus and hypertension. We aimed to investigate the prevalence and risk factors of advanced hepatic fibrosis in patients with various internal diseases. PATIENTS AND METHODS: We performed a community-based survey in which 1,012 patients were enrolled (mean age, 63.1 ± 10.8 years; female/male, 505/507). Hepatic fibrosis was evaluated by Fib-4 index and patients were classified into high and low Fib-4 groups...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29734514/immune-checkpoint-blockade-for-the-treatment-of-human-hepatocellular-carcinoma
#5
REVIEW
Naoshi Nishida, Masatoshi Kudo
Hepatocellular carcinoma (HCC) is one of the most common cancers with a high recurrence rate. Currently, tyrosine kinase inhibitors (TKIs) are the first-line treatment for cases refractory to conventional therapies. However, the acquisition of somatic mutations can result in TKI resistance. Clinical evidence suggests that acquired immunity contributes to the suppression of tumor recurrence, indicating the potential of induced anti-tumor immune reaction for the treatment of HCC. Recently, immune checkpoint inhibitors have become available for the treatment of malignancies...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29734510/association-between-sarcopenia-and-osteoporosis-in-chronic-liver-disease
#6
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Ken Okai, Atsushi Takahashi, Hiromasa Ohira
AIM: Sarcopenia and osteoporosis are important complications in chronic liver disease (CLD). The aim of this study was to investigate the relationship between sarcopenia and osteoporosis in patients with CLD. METHODS: We retrospectively investigated the relationship between sarcopenia and osteoporosis in 112 CLD patients (57 males and 55 females), including 40 cirrhotic patients (36%), by measuring the appendicular skeletal muscle mass index (ASMI) using bio-impedance analysis...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29732655/external-validation-and-improvement-of-life-score-as-a-prediction-tool-in-critically-ill-cirrhosis-patients
#7
Shuangzhe Yao, Xihui Jiang, Chao Sun, Zhongqing Zheng, Bangmao Wang, Tao Wang
PURPOSE: The LiFe (liver, injury, failure, evaluation) score, calculated according to arterial lactate, total bilirubin, and INR, is a novel score for risk prediction in ICU patients with cirrhosis. The present study aimed to externally validate and optimize the LiFe score for predicting outcomes in critically ill cirrhosis patients. METHODS: The study employed the single-center database Medical Information Mart for Intensive Care-III (MIMIC-III) for analysis. A total of 536 critically ill cirrhosis patients from the MIMIC-III database were analyzed...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29732688/restoration-of-nk-cell-activity-by-interferon-free-daas-combination-therapy-in-chronic-hepatitis-c-patient
#8
Ikuo Nakamura, Yoshihiro Furuichi, Katsutoshi Sugimoto
The interferon-free direct-acting antivirals (DAAs) therapy was one of the effective treatment for chronic hepatitis C (CH(C)) patients. NK activity was reported to be impaired in the patients with HCV. The aim of this study was to examine whether DAAs therapy could restore NK activity in CH(C).
May 6, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29732647/serum-wfa-m2bp-level-as-a-diagnostic-marker-of-hepatitis-b-virus-related-hepatocellular-carcinoma
#9
Natthaya Chuaypen, Salyavit Chittmittraprap, Nutcha Pinjaroen, Boonchoo Sirichindakul, Yong Poovorawan, Yasuhito Tanaka, Pisit Tangkijvanich
AIM: Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a novel marker for staging liver fibrosis and predicting hepatocellular carcinoma (HCC) occurrence. This study aimed at evaluating the performance of WFA+-M2BP in the diagnosis of HCC in patients with chronic hepatitis B virus (HBV) infection METHODS: WFA+-M2BP levels were measured in stored samples collected at initial diagnosis of 150 patients with HBV-related HCC and 150 age- and gender-matched patients with non-malignant chronic HBV infection...
May 6, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29726061/transjugular-diagnostics-in-acute-liver-failure-including-measurements-of-hepato-central-venous-biomarker-gradients
#10
Martin Chong Wang, Franziska Wandrer, Jerome Schlué, Torsten Voigtländer, Tim Oliver Lankisch, Michael Peter Manns, Heike Bantel, Thomas von Hahn
AIM: Acute liver failure (ALF) as a syndrome of severe liver injury may need urgent liver transplantation and is associated with significant risk of death. Therefore, early outcome prediction and further possibilities to increase accuracy of prognosis scores remain important. METHODS: We examined 30 patients with ALF according to the novel criteria of the Intractable Hepato-Biliary Diseases Study Group who underwent transjugular liver biopsy (TJLB) and investigated the relevance of histology for correct diagnosis and etiology...
May 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29722107/the-key-roles-of-hepatologists-in-successful-liver-transplantation
#11
REVIEW
Tomomi Kogiso, Katsutoshi Tokushige
Liver transplantation (LT) has been performed for acute liver failure, end-stage liver disease, and congenital metabolic disease in more than 7,000 cases in Japan. LT has been established as a treatment option, and survival rates have improved. In 2016, a new registration/allocation policy and a new scoring system for deceased-donor LT (DDLT) were established. The management of perioperative patients and preoperative therapy for liver failure, nutrition, and preventing infection were upgraded. Moreover, methods for preventing disease recurrence, and treating hepatitis C and B have been developed and are particularly crucial for good outcomes in LT...
May 2, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29710411/photobiomodulation-with-red-light-emitting-diodes-accelerates-hepatocytes-proliferation-through-reactive-oxygen-species-extracellular-signal-regulated-kinase-pathway
#12
Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Syuichi Iwahashi, Yu Saito, Mitsuo Shimada
AIM: Cell-based transplantation is an alternate method of liver transplantation to delay the on-set of end-stage liver diseases. For successful treatment, cells need to be expended in vitro expeditiously. However, autogenetic hepatocytes as the ideal cell source for therapy remain quiescence so proliferation is rare. While photobiomodulation therapy (PBT) has been used to stimulate some kinds of cell proliferation, it is unknown if red light emitting diodes (LED) irradiation can promote primary hepatocyte proliferation...
April 30, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29689631/novel-approaches-for-molecular-targeted-therapy-against-hepatocellular-carcinoma
#13
REVIEW
Yuji Eso, Hiroyuki Marusawa
Systemic chemotherapy using a multi-targeted tyrosine kinase inhibitor is an established treatment for advanced-stage tumors in various organs. Comprehensive genomic analyses using next-generation sequencing technology revealed the intra- and inter-tumor heterogeneity of human hepatocellular carcinomas (HCCs), and provided evidence for the use of therapeutic agents effective against multiple targets in tumor cells. Recently, the efficacy and safety of a multi-targeted tyrosine kinase inhibitor, lenvatinib, was confirmed by a randomized global phase III trial and thus lenvatinib was approved as first-line therapy for HCC, providing a new therapeutic option for patients in an advanced stage...
April 24, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29682855/clinical-outcomes-of-sorafenib-treatment-failure-for-advanced-hepatocellular-carcinoma-and-candidates-for-regorafenib-treatment-in-real-world-practice
#14
Uchikawa Shinsuke, Tomokazu Kawaoka, Hiroshi Aikata, Kenichiro Kodama, Yuno Nishida, Yuki Inagaki, Masahiro Hatooka, Kei Morio, Takashi Nakahara, Eisuke Murakami, Akira Hiramatsu, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Kazuaki Chayama
AIM: As second-line therapy, regorafenib has been shown to provide a survival benefit for patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this retrospective study, we assessed the clinical outcomes of sorafenib treatment failure with regard to second-line chemotherapy. METHODS: Patients (N=160) with advanced HCC, Child-Pugh A liver function and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 treated with sorafenib between June 2009 and September 2016 were enrolled...
April 22, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29679473/novel-quantitative-assessment-system-of-liver-steatosis-using-a-newly-developed-attenuation-measurement-method
#15
Nobuharu Tamaki, Yohei Koizumi, Masashi Hirooka, Norihisa Yada, Hitomi Takada, Osamu Nakashima, Masatoshi Kudo, Yoichi Hiasa, Namiki Izumi
AIM: The present study has developed and evaluated the effectiveness of a new echo attenuation measurement function combined with an ultrasonic diagnostic system for the accurate diagnosis of liver steatosis. METHODS: A multi-center prospective study involving patients with chronic hepatitis was conducted. All patients underwent liver biopsy and attenuation coefficient (ATT) was measured on the same day on which liver biopsy. Fat area (%) of biopsy specimens was quantitatively evaluated...
April 21, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29633526/micrornas-as-possible-biomarkers-for-hepatocellular-carcinoma
#16
EDITORIAL
Asahiro Morishita, Masaki Tsutomu
No abstract text is available yet for this article.
April 6, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29633440/augmenter-of-liver-regeneration-a-key-protein-in-liver-regeneration-and-pathophysiology
#17
REVIEW
Parul Gupta, Senthil Kumar Venugopal
Liver is constantly exposed to pathogens, viruses, chemicals, and toxins, and several of them cause injury leading to the loss of liver mass and sometimes result in cirrhosis and cancer. Under physiological conditions, liver can regenerate if the loss of cells is less than the proliferation of hepatocytes. If the loss is more than the proliferation, the radical treatment available is liver transplantation. Due to this reason, the search for an alternate therapeutic agent has been the focus of liver research...
April 6, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29601141/recurrence-rates-of-pruritus-after-the-stop-of-nalfurafine-hydrochloride-in-chronic-liver-disease-preliminary-prospective-confirmatory-trial
#18
Norio Akuta, Hiromitsu Kumada, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Fumitaka Suzuki, Yasuji Arase, Kenji Ikeda
AIM: The recurrence rates of pruritus after the stop of nalfurafine hydrochloride is unknown in chronic liver disease. METHODS: A prospective confirmatory trial was performed to determine the recurrence rates of pruritus after the stop of nalfurafine hydrochloride in chronic liver disease. After the pretreatment with nalfurafine hydrochloride for 4 weeks or more, 15 consecutive Japanese patients, who confirmed the improvement of pruritus (the decrease in Visual Analogue Scale (VAS) of 50 mm or more), were enrolled in the present study...
March 30, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29601135/effects-of-knee-loading-on-obesity-related-nonalcoholic-fatty-liver-disease-in-an-ovariectomized-mouse-model-with-high-fat-diet
#19
Nian Tan, Xinle Li, Lidong Zhai, Daquan Liu, Jie Li, Hiroki Yokota, Ping Zhang
AIM: Hormonal and nutritional disorders are the main causes of obesity and nonalcoholic fatty liver disease, especially in the elderly and postmenopausal women. Although physical activity may alleviate these disorders, the elderly may often have difficulty in conducting physical exercise. The purpose of this study was to investigate the therapeutic effect of knee loading, a new form of physical stimulation, on the symptom of obesity and fatty liver. METHODS: Using ovariectomized mice with high fat diet, we evaluated the effect of knee loading that applies gentle cyclic loads to the knee...
March 30, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29504692/efficacy-of-ledipasvir-sofosbuvir-with-or-without-ribavirin-for-12-weeks-in-genotype-1b-hcv-patients-previously-treated-with-a-nonstructural-protein-5a-inhibitor-containing-regimen
#20
Hiroki Ikeda, Tsunamasa Watanabe, Hirohito Shimizu, Tetsuya Hiraishi, Rena Kaneko, Toshiyuki Baba, Hideaki Takahashi, Kotaro Matsunaga, Nobuyuki Matsumoto, Hiroshi Yasuda, Chiaki Okuse, Shogo Iwabuchi, Michihiro Suzuki, Fumio Itoh
AIM: The therapeutic benefit of adding ribavirin (RBV) to 12 weeks of ledipasvir/sofosbuvir (LDV/SOF) for patients who experienced failure of a previous nonstructural protein (NS) 5A inhibitor-containing regimen is unclear. METHODS: A total of 29 genotype 1b HCV patients who had failed prior daclatasvir (DCV) plus asunaprevir (ASV) treatment were retreated for 12 weeks of LDV/SOF, with or without RBV. Antiviral efficacy and predictive factors associating with a sustained virological response at 24 weeks (SVR24) were evaluated retrospectively...
March 5, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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