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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/29150974/reciprocal-interactions-between-bile-acids-and-gut-microbiota-in-human-liver-diseases
#1
REVIEW
Tadashi Ikegami, Akira Honda
The gut microbiota (GM) play a central role in their hosts' metabolism of bile acids (BAs) by regulating deconjugation, dehydroxylation, dehydrogenation, and epimerization reactions to generate unconjugated free BAs and secondary BAs. These BAs generated by the GM are potent signaling molecules that interact with BA receptors, such as the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5). Each BA has a differential affinity to these receptors; therefore, alterations in BA composition by GM could modify the intensity of receptor signaling...
November 18, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29150971/authors-reply-to-the-letter-to-the-editor
#2
LETTER
Hisashi Hidaka, Shigehiro Kokubu
No abstract text is available yet for this article.
November 18, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29125895/impact-of-preserved-collateral-veins-on-small-for-size-grafts-in-living-donor-liver-transplantation
#3
Seong Hoon Kim, Eung Chang Lee, Sang Jae Park
AIM: Graft size is a critical issue in living donor liver transplantation (LDLT). We hypothesized that too much portal flow could possibly be diverted into pre-existing collateral veins, alleviating small-for-size syndrome (SFSS) in LDLT. This study evaluated the impact of the preserved collateral veins in the outcomes of LDLT using a small-for-size graft (SFSG). METHODS: For patient safety, a graft-to-recipient weight ratio (GRWR) < 0.8% was strictly confined to patients with collateral veins (group A), and the patient group was compared in a 1:3 ratio to a matched group of patients with GRWR ≥ 0...
November 10, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29115721/loss-of-skeletal-muscle-mass-in-patients-with-chronic-liver-disease-is-related-to-decrease-in-bone-mineral-density-and-exercise-tolerance
#4
Fumikazu Hayashi, Masaki Kaibori, Tatsuma Sakaguchi, Kosuke Matsui, Morihiko Ishizaki, A-Hon Kwon, Junji Iwasaka, Yutaka Kimura, Daiki Habu
AIM: This study aimed to identify the relationship between loss of skeletal muscle mass and clinical factors such as osteoporosis in patients with chronic liver disease. METHODS: The subjects were 112 patients (85 men, 27 women) with hepatocellular carcinoma who were scheduled to undergo hepatectomy. Skeletal muscle reduction was diagnosed according to the cutoff level of the skeletal mass index (SMI) for Asians (men <7.0 kg/m(2) , women <5.4 kg/m(2) ). Osteoporosis was diagnosed according to T-score ≤-2...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29115717/changes-in-liver-function-and-body-composition-by-direct-acting-antiviral-therapy-for-hepatitis-c-virus-infection
#5
Ryosuke Sugimoto, Motoh Iwasa, Nagisa Hara, Yasuyuki Tamai, Kyoko Yoshikawa, Suguru Ogura, Hideaki Tanaka, Akiko Eguchi, Norihiko Yamamoto, Yoshinao Kobayashi, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Management of low skeletal muscle mass (LSM) is a very important topic since LSM affects patient mortality in liver diseases. Changes in body composition are unexplored in chronic hepatitis C virus (HCV) patients, including those with liver cirrhosis, who receive direct-acting antiviral (DAA) therapy. Body composition measurements and liver function tests were performed before and after DAA therapy. METHODS: Blood examination, visceral fat area (VFA) and extremity skeletal muscle mass were measured using the multi-frequency bioelectrical impedance analysis method: i) at 24 weeks pre DAA therapy; ii) at the start of DAA therapy; iii) at the end of DAA therapy; iv) at 24 weeks post DAA therapy; and v) at 48 weeks post DAA therapy...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29115027/clinical-features-of-pediatric-autoimmune-hepatitis-in-japan-a-nationwide-survey
#6
Tsuyoshi Sogo, Atsushi Takahashi, Ayano Inui, Tomoo Fujisawa, Hiromasa Ohira, Hajime Takikawa
AIM: The purpose of this study was to determine the characteristics of children with autoimmune hepatitis (AIH) in Japan. METHODS: Questionnaires, which asked about patients newly diagnosed with AIH from 2009 to 2013 were sent to hospitals certified as training facilities for pediatrics in January 2015. RESULTS: A total of 35 patients were enrolled. The median age at diagnosis was 10 years (ranging from 3 months to 15 years), and the male-to-female ratio was 2:3...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29114991/serum-autotaxin-is-a-useful-liver-fibrosis-marker-in-patients-with-chronic-hepatitis-b-virus-infection
#7
Satoru Joshita, Yuki Ichikawa, Takeji Umemura, Yoko Usami, Ayumi Sugiura, Soichiro Shibata, Tomoo Yamazaki, Naoyuki Fujimori, Michiharu Komatsu, Akihiro Matsumoto, Koji Igarashi, Masao Ota, Eiji Tanaka
BACKGROUND AND AIMS: Autotaxin (ATX) is a secreted enzyme that is considered to be associated with liver damage as well as fibrosis. This study assessed the ability of ATX to diagnose liver fibrosis in patients with chronic hepatitis B virus (HBV) infection. METHODS: Serum ATX levels were retrospectively evaluated in 101 treatment-naïve patients with HBV-related chronic hepatitis or cirrhosis all of whom had undergone liver biopsy at our hospital. RESULTS: Serum ATX concentration increased significantly according to liver fibrosis stage in overall (r = 0...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29114970/risk-factors-for-exacerbations-of-gastroesophageal-varices-and-portosystemic-encephalopathy-during-treatment-with-nucleos-t-ide-analogs-for-hepatitis-b-virus-related-cirrhosis
#8
Yuko Nagaoki, Hiroshi Aikata, Kana Daijyo, Yuji Teraoka, Fumi Honda, Yuki Nakamura, Masahiro Hatooka, Kei Morio, Hatsue Fujino, Takashi Nakahara, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hidenori Ochi, Kazuaki Chayama
AIM: The aim of this study was to determine the risk factors for worsening of gastroesophageal varices (GEVs) and development of portosystemic encephalopathy in patients with hepatitis B virus (HBV)-related cirrhosis during nucleos(t)ide analogs (NAs) treatment. METHODS: 137 patients with HBV-related cirrhosis were enrolled in this retrospective cohort study. Findings of portal hemodynamics with CT, liver function and endoscopic examination during NAs treatment were examined...
November 8, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29098752/hemobilia-immediately-after-transcatheter-arterial-chemoembolization-using-drug-eluting-beads-for-hepatocellular-carcinoma-with-intrahepatic-bile-duct-invasion
#9
Maiko Nishi, Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida
Transcatheter arterial chemoembolization (TACE) is used as a palliative treatment for unresectable hepatocellular carcinoma (HCC) worldwide. Recently, a novel drug delivery-embolic agent, the drug-eluting bead (DEB), was introduced for TACE. There are a few reports of tumor hemorrhage after TACE using DEB (DEB-TACE) for HCC. However, there have not been any reports of hemobilia immediately after DEB-TACE for an HCC with intrahepatic bile duct invasion. Here, the first such case is reported. A 71-year-old woman was admitted to our hospital to undergo DEB-TACE for multiple HCCs with worsening left intrahepatic bile duct dilatation...
November 2, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29080280/usefulness-of-semiquantitative-pcr-invader-assay-for-selecting-candidates-for-daclatasvir-plus-asunaprevir-combination-therapy-among-patients-with-hepatitis-c-virus-genotype-1b
#10
Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Masanori Tokoro, Masao Iwao, Tetsu Mori, Junko Nishimura, Yukou Takahashi, Kaoru Omori, Tsutomu Yamashita, Toyokichi Muro, Kazunari Murakami
BACKGROUND & AIMS: PCR-Invader is a highly sensitive assay for detecting nonstructural protein 5A (NS5A) resistance-associated variants (RAVs) of hepatitis C virus (HCV). Here, we validated the accuracy of the semiquantitative PCR-Invader (SQ-PI) assay compared to direct sequencing (DS) for identifying NS5A RAVs, and we evaluated the treatment efficacy of daclatasvir plus asunaprevir (DCV+ASV) for patients judged to be nonpositive for NS5A RAVs by SQ-PI. METHODS: Detection rates of NS5A RAVs by SQ-PI and DS were compared for 204 patients with HCV genotype 1b...
October 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29059700/a-favorable-response-to-the-immunosuppressive-combination-therapy-with-mizoribine-and-azathioprine-in-children-with-primary-sclerosing-cholangitis
#11
Hitoshi Tajiri, Yoh Zen, Tomoko Takano, Stephen Brooks
AIM: Primary sclerosing cholangitis (PSC), with no curative intervention, can progress to end-stage liver disease. Mizoribine, a purine anti-metabolic, has never been used for the management of PSC. To evaluate the role of mizoribine with azathioprine we performed a preliminary clinical study in children with PSC. METHODS: Children with PSC and autoimmune features were simultaneously treated with mizoribine and azathioprine. Ursodeoxycholic acid or mesalazine were not regulated...
October 23, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29059699/identification-of-the-genomic-region-under-epigenetic-regulation-during-nonalcoholic-fatty-liver-disease-progression
#12
Kikuko Hotta, Takuya Kitamoto, Aya Kitamoto, Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Masato Yoneda, Kento Imajo, Wataru Tomeno, Satoru Saito, Atsushi Nakajima
AIM: The progression of nonalcoholic fatty liver disease (NAFLD) is affected by epigenetics. We performed co-methylation and differentially methylated region (DMR) analyses to identify the genomic region that is under epigenetic regulation during NAFLD progression. METHODS: We collected liver biopsy specimens from 60 Japanese patients with NAFLD and classified these into mild (fibrosis stages 0-2) or advanced (fibrosis stages 3-4) NAFLD. We performed genome-wide DNA methylation analysis and identified the differentially methylated CpGs between mild and advanced NAFLD...
October 23, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29055114/sorafenib-response-in-hepatocellular-carcinoma-micrornas-as-tuning-forks-mirnas-as-regulators-of-sorafenib-response-in-hcc
#13
REVIEW
Shruthi Kanthaje, Ankita Makol, Anuradha Chakraborti
Hepatocellular carcinoma (HCC), the primary liver malignancy attributes towards the second foremost cause of cancer related mortality. The targeted chemotherapeutic agent, sorafenib is known to exhibit a statistically significant but limited overall survival advantage in advanced HCC. However, the individual patient response towards sorafenib varies drastically with most of them demonstrating stable disease (SD), few with partial response (PR) and very rare complete response (CR). Progressive disease (PD) despite the treatment has also been demonstrated in many patients indicating drug resistance...
October 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28984014/increased-serum-c-reactive-protein-and-decreased-urinary-aquaporin-2-levels-are-predictive-of-the-efficacy-of-tolvaptan-in-patients-with-liver-cirrhosis
#14
Masato Nakai, Koji Ogawa, Rei Takeda, Masatsugu Ohara, Naoki Kawagishi, Takaaki Izumi, Machiko Umemura, Jun Ito, Takuya Sho, Goki Suda, Kenichi Morikawa, Naoya Sakamoto
AIM: Water retention, hepatic ascites, and peripheral edema are significant problems in patients with liver cirrhosis (LC). Although furosemide and spironolactone are commonly used as treatment, these are often insufficient to treat hyponatremia and renal insufficiency in patients with LC. Tolvaptan (TVP) could provide an effective treatment alternative. However, predictive factors of a therapeutic response to TVP are unclear. Our aim was to examine clinical predictors of the response to TVP in patients with LC and water retention...
October 6, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28984009/microrna-125b-expression-and-intrahepatic-metastasis-are-predictors-for-early-recurrence-after-hepatocellular-carcinoma-resection
#15
Tomonari Shimagaki, Tomoharu Yoshizumi, Norifumi Harimoto, Sachiyo Yoshio, Yutaka Naito, Yusuke Yamamoto, Takahiro Ochiya, Yoshihiro Yoshida, Tatsuya Kanto, Yoshihiko Maehara
AIM: Early hepatocellular carcinoma (HCC) recurrence after curative resection is a known poor prognostic factor. We aimed to identify microRNAs associated with recurrence after curative HCC resection. METHODS: To identify risk factors for early recurrence and metastasis, 694 patients who underwent primary curative HCC resection were analyzed. We evaluated microRNA expression in cancerous and noncancerous tissues by microarray and qPCR analyses using 16 HCC samples...
October 6, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28975687/comment-to-antithrombin-iii-administration-for-portal-vein-thrombosis-in-patients-with-liver-disease-a-randomized-double-blind-controlled-trial
#16
LETTER
Annabel Blasi, Fuat Saner, Gianni Biancofiore, Ton Lisman
No abstract text is available yet for this article.
October 3, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28960812/pilot-study-for-hepatitis-virus-screening-among-employees-and-effective-approach-to-encourage-screened-positive-employees-to-receive-medical-care-in-japan
#17
Aya Sugiyama, Toshiko Fujii, Shintaro Nagashima, Masayuki Ohisa, Chikako Yamamoto, Chuon Channarena, Tomoyuki Akita, Junko Matsuo, Keiko Katayama, Kazuaki Takahashi, Junko Tanaka
BACKGROUND & AIMS: Countermeasures against hepatitis B and C virus (HBV, HCV) infection at work sites in Japan have not yet been implemented. This study aimed to determine the status of viral hepatitis infection among the employees in Japan. METHODS: We conducted a workplace-based cross-sectional study from 2011 to 2016 in Hiroshima. HBV and HCV markers were identified during a routine checkup of employees in 15 enterprises. The screening results were sent to employees directly and not to employers...
September 27, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28960692/does-the-intestinal-microenvironment-have-an-impact-on-the-choleretic-effect-of-inchinkoto-a-hepatoprotective-herbal-medicine
#18
Masahito Uji, Yukihiro Yokoyama, Takashi Asahara, Tomoki Ebata, Tsuyoshi Igami, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: The choleretic effects of Inchinkoto (ICKT), a hepatoprotective herbal medicine, are variable among patients. This study sought to investigate the correlation between the choleretic effects of ICKT and the intestinal microenvironment in patients with biliary obstruction. METHODS: Patients with biliary obstruction who underwent external biliary drainage were enrolled. The concentrations of total bilirubin and bile acid in the bile, and genipin, a major active ingredient of ICKT, in the bloodstream before and after ICKT administration were measured...
September 27, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28940597/muscle-volume-loss-a-prognostic-factor-for-death-in-liver-cirrhosis-patients-and-special-relationship-to-portal-hypertension
#19
Atsushi Hiraoka, Shogo Kitahata, Hirofumi Izumoto, Hidetaro Ueki, Toshihiko Aibiki, Tomonari Okudaira, Yuji Miyamoto, Hiroka Yamago, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Masato Kishida, Eiji Tsubouchi, Hideki Miyata, Tomoyuki Ninomiya, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Kojiro Michitaka
BACKGROUND/AIM: We examined the prognosis of liver cirrhosis (LC) patients with and without portal hypertension (PHT) and muscle volume loss (MVL). MATERIALS/METHODS: From 2006 to 2016, 346 LC outpatients (PHT/non-PHT=173/173) were enrolled [median age 69 years, males/females=204/142; Child-Pugh A/B=230/116, presence of MVL 15.6% in each group] after performing propensity matching, following exclusion of those with hepatocellular carcinoma (HCC) beyond the Milan criteria and Child-Pugh C...
September 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28902450/current-status-of-portal-vein-thrombosis-in-japan-results-of-a-questionnaire-survey-by-the-japan-society-for-portal-hypertension
#20
Seiichiro Kojima, Norihito Watanabe, Jun Koizumi, Shigehiro Kokubu, Naoya Murashima, Shoichi Matsutani, Katsutoshi Obara
AIM: To investigate the current status of portal vein thrombosis (PVT) in Japan, the Clinical Research Committee of the Japan Society of Portal Hypertension undertook a questionnaire survey. METHODS: A questionnaire survey of 539 cases of PVT over the previous 10 years was carried out at institutions affiliated with the Board of Trustees of the Japan Society of Portal Hypertension. RESULTS: The most frequent underlying etiology of PVT was liver cirrhosis in 75...
September 13, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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