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Hepatology Research: the Official Journal of the Japan Society of Hepatology

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https://www.readbyqxmd.com/read/29341419/fatty-liver-index-predicts-incident-diabetes-in-a-japanese-general-population-with-and-without-impaired-fasting-glucose
#1
Aya Hirata, Daisuke Sugiyama, Kazuyo Kuwabara, Takumi Hirata, Hiromi Tsutatani, Mika Funamoto, Kouiti Watanabe, Naomi Miyamatsu, Tomonori Okamura
AIM: Fatty liver is associated with the development of diabetes. However, to our knowledge, no study has examined the relationship between the fatty liver index (FLI), calculated scores of hepatic steatosis, and the development of diabetes among individuals without impaired fasting glucose (IFG). We aimed to examine whether FLI predicts the development of diabetes in individuals with and without IFG in a Japanese general population. METHODS: We selected 1,498 males and 2,941 females who participated in Specific Health Checkups in Japan...
January 17, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29341357/a-multicenter-pilot-survey-to-clarify-the-clinical-features-of-patients-with-acute-on-chronic-liver-failure-in-japan
#2
Nobuaki Nakayama, Hayato Uemura, Yoshihito Uchida, Tomoaki Tomiya, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, Hajime Takikawa, Satoshi Mochida
AIMS: To establish diagnostic criteria for acute-on-chronic liver failure (ACLF) in Japan, a multicenter pilot survey was conducted to examine usefulness of oversea criteria in patients with chronic liver diseases manifesting acute decompensation. METHODS: Patients fulfilling the APASL, EASL or Chinese Medical Association (CMA) criteria for decompensation were enrolled from 8 institutes, and the clinical features were evaluated. RESULTS: Among 112 patients, 109 patients (97...
January 17, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29336092/development-and-validation-of-a-scoring-system-to-predict-progression-to-acute-on-chronic-liver-failure-in-patients-with-acute-exacerbation-of-chronic-hepatitis-b
#3
Yi Ren, Lulu Liu, Ying Li, Fangwan Yang, Yihuai He, Yanping Zhu, Xinxin Hu, Shide Lin
AIM: The aim of this study was to develop and validate a scoring system to predict the progression to acute-on-chronic liver failure (ACLF) in patients with acute exacerbation (AE) of chronic hepatitis B (CHB). METHODS: The baseline characteristics of 474 patients with AE of CHB were retrospectively reviewed; 280 and 194 patients were randomly assigned to the derivation and validation cohorts, respectively. Univariate risk factors associated with ACLF development were entered into a multivariate logistic regression...
January 15, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29333633/long-term-outcome-of-stereotactic-body-radiotherapy-for-patients-with-small-hepatocellular-carcinoma
#4
Katsumaro Kubo, Tomoki Kimura, Hiroshi Aikata, Shigeo Takahashi, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Kazuaki Chayama, Yasushi Nagata
AIM: To evaluate the long-term outcome of stereotactic body radiotherapy in patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. METHODS: Sixty-five patients with 74 hepatocellular carcinomas (median tumor size, 16 mm) were enrolled in this study. They were treated with the prescribed dose of 48 Gy in four fractions at the isocenter. We extended the observation period and analyzed long-term outcomes, including overall survival, progression-free survival, local control, and various prognostic factors, in these patients...
January 14, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29330965/intra-hepatic-bile-duct-primary-cilia-in-biliary-atresia
#5
Roberta Frassetto, Filippo Parolini, Salvatore Marceddu, Giulia Satta, Valeria Papacciuoli, Maria Antonia Pinna, Alessandra Mela, Giannina Secchi, Grazia Galleri, Roberto Manetti, Luisa Bercich, Vincenzo Villanacci, Antonio Dessanti, Roberto Antonucci, Francesco Tanda, Daniele Alberti, Kathleen B Schwarz, Maria Grazia Clemente
AIM: The etiopathogenesis of non-syndromic biliary atresia (BA) is obscure. The primary aim was to investigate intra-hepatic bile duct cilia (IHBC) in BA at the diagnosis and correlation with clinical outcome. The secondary aim was to analyze IHBC in routine paraffin-embedded liver biopsies using conventional scanning electron microscopy (SEM). METHODS: Surgical liver biopsies taken at the diagnosis from 22 BA infants (age range: 39 - 116 days) and from 8 children with non-BA chronic cholestasis (age range: 162 days -16,8 years) were evaluated for IHBC, both by immunofluorescence (IF) and by SEM...
January 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29330919/meta-analysis-of-laparoscopic-versus-open-liver-resection-for-hepatocellular-carcinoma
#6
Bin Jiang, Xiufang Yan, Jian-Huai Zhang
OBJECTIVE: To evaluate surgical safety and effectiveness of laparoscopic hepatectomy(LH) in short- and long-term outcomes compared to open hepatectomy(OH) in patients operated for hepatocellular carcinoma (HCC). METHODS: An electronic search until August 2017 was conducted to identify comparative studies evaluating laparoscopic versus open liver resection for HCC. RESULTS: A total of 5889 patients (2421 underwent LH, and 3468 with OH) were included in our meta-analysis from 47 studies...
January 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316097/splicing-analysis-of-rare-novel-synonymous-or-intronic-variants-identified-in-abcb11-heterozygotes-presenting-as-progressive-intrahepatic-cholestasis-with-low-%C3%AE-glutamyltransferase
#7
Neng-Li Wang, Yi-Ling Qiu, Wen-Cai Guan, Gang Li, Yi Lu, Mei-Hong Zhang, Wei-Sha Luan, Jian-She Wang
AIM: To analyze the pathogenicity of rare/novel synonymous or intronic variants identified in ABCB11 heterozygotes presenting as progressive intrahepatic cholestasis with low γ-glutamyltransferase (GGT). METHODS: The enrolled variants were identified in ABCB11 between October 2009 and June 2016. The effects on pre-RNA splicing were analyzed by in silico tools and minigene splicing assay. RESULTS: There were 3 intronic (c.908+5G>A, c.2815-8A>G, and c...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316082/minimally-invasive-liver-resection-for-hepatocellular-carcinoma-of-patients-with-liver-damage-b-a-propensity-score-based-analysis
#8
Takehiro Noda, Hidetoshi Eguchi, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Kunihito Gotoh, Koichi Kawamoto, Shogo Kobayashi, Yasuji Hashimoto, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori
AIMS: Minimally invasive liver resection (MILR) is considered as safe and feasible treatment for malignant liver tumors. However, few studies have investigated the surgical outcomes of MILR in patients with impaired liver function. Liver damage is used for consideration of hepatectomy. The aim of this study is to clarify the efficacy of MILR for patients with impaired liver function by using the propensity score matching. METHODS: Ninety nine patients with liver damage B underwent hepatic resection were analyzed...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316062/efficacy-and-safety-of-ombitasvir-paritaprevir-ritonavir-combination-therapy-for-genotype-1b-chronic-hepatitis-c-patients-complicated-with-chronic-kidney-disease
#9
Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Tadashi Ikegami, Noritomo Shimada, Keizo Kato, Hiroshi Abe, Tomomi Okubo, Norio Itokawa, Chisa Kondo, Shigeru Mikami, Toru Asano, Yoshimichi Chuganji, Yasushi Matsuzaki, Hidenori Toyoda, Takashi Kumada, Etsuko Iio, Yasuhito Tanaka, Katsuhiko Iwakiri
AIM: The aim of this study was to clarify the effects and safety of ombitasvir/paritaprevir/ritonavir (OBT/PTV/r) therapy in genotype 1b chronic hepatitis C patients with non-dialysis chronic kidney disease (CKD). METHODS: This retrospective, multicenter study of 12-week OBT/PTV/r therapy included genotype 1b patients with non-dialysis CKD. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 . Virologic responses and treatment-emergent adverse events (TEAEs) in patients with CKD were compared with those in patients without CKD...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316057/-a-promising-medium-term-follow-up-of-pediatric-sclerosing-cholangitis-mild-phenotype-or-early-diagnosis
#10
F Ferrari, G Ranucci, M Aloi, L Della Volpe, F Viola, E Miele, S Cucchiara, R Iorio
BACKGROUND AND AIMS: Sclerosing cholangitis (SC) is a chronic cholestatic liver disease whose diagnosis is being increasingly recognized in childhood. Long-term course and prognosis of pediatric SC is poorly described. METHODS: We reviewed data of pediatric SC patients, followed in two referral centers during a period of up to 20 years. We aimed to evaluate long-term outcomes according to SC phenotype. RESULTS: Among 45 patients (median age: 10...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316051/safety-and-efficacy-of-sofosbuvir-and-ribavirin-for-genotype-2-hepatitis-c-japanese-patients-with-renal-dysfunction
#11
Takuya Sho, Goki Suda, Atsushi Nagasaka, Yoshiya Yamamoto, Ken Furuya, Kenichi Kumagai, Minoru Uebayashi, Katsumi Terashita, Tomoe Kobayashi, Izumi Tsunematsu, Manabu Onodera, Takashi Meguro, Megumi Kimura, Jun Ito, Machiko Umemura, Takaaki Izumi, Naoki Kawagishi, Masatsugu Ohara, Yuji Ono, Masato Nakai, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
BACKGROUND AND AIM: The safety and efficacy of sofosbuvir and ribavirin have not been well clarified in patients with renal dysfunction because clinical trials did not include such patients. We evaluated the safety and efficacy of sofosbuvir and ribavirin for genotype 2 hepatitis C virus (HCV)-infected patients with renal dysfunction. METHODS: The study included genotype 2 HCV-infected patients who received sofosbuvir and ribavirin between July 2014 and May 2017...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316028/wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-predicts-the-development-of-hepatocellular-carcinoma-in-patients-with-nonalcoholic-fatty-liver-disease
#12
Miwa Kawanaka, Yasuyuki Tomiyama, Hideyuki Hyogo, Masahiko Koda, Toshihide Shima, Hiroshi Tobita, Akira Hiramatsu, Ken Nishino, Toshiaki Okamoto, Shuichi Sato, Yuichi Hara, Sohji Nishina, Hirofumi Kawamoto, Kazuaki Chayama, Takeshi Okanoue, Keisuke Hino
AIM: As it is not practical to survey hepatocellular carcinoma (HCC) in all patients with nonalcoholic fatty liver disease (NAFLD), there is a need to identify NAFLD patients who are at high risk for HCC. Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) has been demonstrated to be a surrogate marker for predicting HCC as well as a liver fibrosis marker in patients with chronic hepatitis B and C. The aim of this study was to investigate whether WFA+ -M2BP predicts HCC development in NAFLD patients...
January 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316085/deletion-of-endoplasmic-reticulum-stress-responsive-co-chaperone-p58ipk-protects-mice-from-diet-induced-steatohepatitis
#13
Harikrishna Bandla, Debanjali Dasgupta, Amy S Mauer, Barbora Nozickova, Swarup Kumar, Petra Hirsova, Rondell P Graham, Harmeet Malhi
Activation of the endoplasmic reticulum stress sensor PERK is a feature of nonalcoholic steatohepatitis (NASH), yet regulators of PERK signaling remain undefined in this context. P58IPK regulates PERK; however, its role in NASH has not been examined. AIM: the aim of this study was to assess the in vivo role of p58IPK in the pathogenesis of dietary NASH. METHODS: parameters of hepatocyte cell death, liver injury, inflammation, fibrosis, indirect calorimetry and PERK activation were assessed in p58IPK knockout (p58ipk-/- ) mice and their wildtype littermate controls fed a diet enriched in Fat, Fructose, and Cholesterol (FFC) for 20 weeks...
January 5, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29316059/cost-effectiveness-analyses-of-anti-hcv-treatments-using-qol-scoring-among-patients-with-chronic-liver-disease-in-the-hiroshima-prefecture
#14
Terumi Kaishima, Tomoyuki Akita, Masayuki Ohisa, Kazuaki Sakamune, Akemi Kurisu, Aya Sugiyama, Hiroshi Aikata, Kazuaki Cyayama, Junko Tanaka
AIM: We estimated the cost-effectiveness of direct acting antiviral treatment (DAA) compared to triple therapy (simeprevir, pegylated interferon-α and ribavirin) (scenario-1) and Peg-IFN+RBV(scenario-2) and non-antiviral therapy(scenario-3). METHODS: The Cost-effectiveness was evaluated as incremental cost-effectiveness ratios (ICERs) using direct costs and indirect costs which included loss of wages during the patient's lifetime due to early death caused by viral hepatitis infection...
January 5, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29314573/higher-efficacy-of-pegylated-interferon-alpha-2b-add-on-therapy-in-hbeag-positive-chronic-hepatitis-b-patients-on-tenofovir-monotherapy
#15
Ankur Jindal, Ashish Kumar Vyas, Devesh Kumar, Guresh Kumar, Manoj Kumar Sharma, Shiv Kumar Sarin
BACKGROUND: Monotherapy with Peg-IFNα or nucleos(t)ide analogues(NA) currently approved for treating chronic hepatitis B(CHB) have limited efficacy. Studies on combination of Peg-IFN-α/NA have shown conflicting results. We investigated whether sequential adding-on Peg-IFNα to tenofovir enhances serological response rates. METHODS: Treatment naïve, HBeAg-positive CHB patients with moderately elevated ALT(48 to 200IU/mL) were started on tenofovir(300 mg/day) and enrolled at week 12 in 1:1 ratio to either receive Peg-IFNα2b add-on(1...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29314571/relative-changes-in-handgrip-strength-and-skeletal-muscle-volume-in-patients-with-chronic-liver-disease-over-two-year-observation-period
#16
Atsushi Hiraoka, Kojiro Michitaka, Hirofumi Izumoto, Hidetaro Ueki, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Yuji Miyamoto, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Yoichi Hiasa
BACKGROUND/AIM: There are few reports regarding relative changes in muscle function of patients with chronic liver disease (CLD). We examined CLD patients to evaluate relative changes in handgrip strength and muscle volume. MATERIAL/METHODS: We enrolled 413 CLD outpatients who underwent handgrip strength measurements in both 2015 and 2017 [age 67.9±10.0 years, male/female=242/171, HCV/HBV/HBV&HCV/alcohol/others=239/92/4/22/56, Child-Pugh score (CPS) in 2017 (5/6/7/8/9/≥10=319/56/13/11/5/9)]...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29314465/sequential-therapy-involving-an-early-switch-from-entecavir-to-pegylated-interferon-%C3%AE-in-japanese-patients-with-chronic-hepatitis-b
#17
Masaru Enomoto, Shuhei Nishiguchi, Akihiro Tamori, Ritsuzo Kozuka, Hideki Fujii, Sawako Uchida-Kobayashi, Shinya Fukunishi, Yasuhiro Tsuda, Kazuhide Higuchi, Masaki Saito, Hirayuki Enomoto, Norifumi Kawada
AIM: The optimal combination of the two currently available agents with different mechanisms of action, a nucleos(t)ide analog and pegylated interferon-α (PegIFNα), must be determined to improve treatment of chronic hepatitis B. METHODS: In this study, 24 patients with chronic hepatitis B (14 hepatitis B e-antigen [HBeAg]-positive and 10 HBeAg-negative) received entecavir for 36-52 weeks, followed by entecavir plus PegIFNα-2a for 4 weeks and finally by PegIFNα-2a alone for 44 weeks...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29278654/up-to-seven-criteria-as-a-useful-predictor-for-tumor-downstaging-to-within-milan-criteria-and-child-pugh-grade-deterioration-after-the-initial-conventional-tace
#18
Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Takaya Takeguchi, Yuko Takeguchi, Mao Okada, Wan Wang, Yohei Kubota, Tomoyuki Goto, Yasuyuki Komiyama, Mayu Higuchi, Kenta Takaura, Tsuguru Hayashi, Hitomi Takada, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Nobuyuki Enomoto, Yoshiro Himeno, Namiki Izumi
AIMS: Intermediate-stage hepatocellular carcinoma varies widely in tumor burden and liver function. This study aimed to clarify the importance of subclassification by the up-to-seven criteria in both clinical course and liver function deterioration in such patients. METHODS: We retrospectively analyzed 224 patients with Child-Pugh grade A who underwent initial transarterial chemoembolization for hepatocellular carcinoma. Tumor downstaging to within Milan criteria within 1 year and liver function worsening as Child-Pugh grade deterioration from A to B were analyzed...
December 26, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29277961/liver-resection-of-hepatocellular-carcinoma-in-patients-with-portal-hypertension-and-multiple-tumors
#19
Takao Ohkubo, Yutaka Midorikawa, Hisashi Nakayama, Masamichi Moriguchi, Osamu Aramaki, Shintaro Yamazaki, Tokio Higaki, Tadatoshi Takayama
AIM: Liver resection for hepatocellular carcinoma (HCC) has been recommended only for patients with a single tumor without portal hypertension. We aimed to validate this treatment strategy that is based on by the Barcelona Clinic Liver Cancer staging system. METHODS: Patients undergoing liver resection were divided into two groups: patients with single HCC without portal hypertension (Group 1) and those with at least one factors of portal hypertension and multiple tumors, up to three lesions each ≤3 cm (Group 2)...
December 26, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29274190/serum-wfa-mac-2-binding-protein-more-reliably-distinguishes-liver-fibrosis-stages-in-non-alcoholic-fatty-liver-disease-than-serum-mac-2-binding-protein
#20
Masanori Atsukawa, Akihito Tsubota, Tomomi Okubo, Taeang Arai, Ai Nakagawa, Norio Itokawa, Chisa Kondo, Keizo Kato, Tsutomu Hatori, Hiroshi Hano, Tsunekazu Oikawa, Naoya Emoto, Masanori Abe, Masayoshi Kage, Katsuhiko Iwakiri
AIM: Serum Mac-2 binding protein (M2BP) and Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) are used to estimate the liver fibrosis stage in chronic liver diseases. However, few head-to-head study has been conducted to compare the two biomarkers in non-alcoholic fatty liver disease (NAFLD). METHODS: Serum M2BP and WFA+ -M2BP levels were compared against clinical characteristics and liver histological manifestations in the same samples collected from 213 biopsy-proven NAFLD patients...
December 23, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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