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Human Antibodies

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https://www.readbyqxmd.com/read/29945350/antibodies-prevalence-against-haemophilus-influenzae-type-b-in-jeddah-population-saudi-arabia-i-total-antibodies
#1
Adi Essam Zarei, Elrashdy M Redwan
In this national comprehensive seroprevalence study, indirect ELISA test was used to evaluate Haemophilus influenzae type b (Hib) anti-polyribosyl-ribitol phosphate (PRP) total antibodies (IgM, IgG, IgA) in 1,003 sera samples from routine medical check-up of healthy individuals attending the local medical facility in Jeddah, Saudi Arabia in the period from February 2014 to January 2016. Serum anti-CPS antibodies confer immunity against invasive Hib disease. An anti-CPS concentration of ⩾ 0.15 μg/mL is believed to be a serological indication for short-term immunity protection against invasive Hib disease, while a concentration of ⩾ 1...
June 15, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29889063/down-regulation-of-rora-gene-expression-in-the-blood-of-multiple-sclerosis-patients
#2
Arezou Sayad, Tayyebali Salmani, Maryam Kazemzadeh Hemmesi, Maziar Ganji, Soudeh Ghafouri-Fard, Mahsa Hatami, Mohammad Soudyab, Mohammad Taheri
Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and loss of oligodendrocytes. The demyelination process is caused by various subsets of CD4+ T cells with a Th1 and Th17 phenotype. The retinoid acid-related orphan receptor A (RORA) is expressed in Th17 cells and promote Th17 differentiation. In this study, we compared the expression level of RORA gene in the blood of 50 relapsing-remitting MS (RRMS) patients who were treated with IFN-β and 50 healthy controls by TaqMan Quantitative Real-Time PCR...
May 25, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29889062/obtaining-and-characterization-of-anti-testis-monoclonal-antibodies-invaluable-tools-toward-the-identification-of-testis-antigens-involved-in-fertilization
#3
Hemati Atefeh, Azarnia Mahnaz, Modaresi Mohammadhosein, Rahimi Amir
BACKGROUND: Generation and utilization of the specific monoclonal antibodies against testis antigens is reported to identify the antigens that are important in reproductive field. OBJECTIVE: Current study aimed to introduce a hybridoma that producing a specific anti-testis monoclonal antibody to identify the testis antigens that can be important in the reproduction field. METHODS: To make hybridoma against testis antigens, mice were immunized with testis cell lysate...
May 25, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29843230/pneumococcal-disease-burden-clinical-presentations-and-vaccine-coverage-in-the-jamaican-population
#4
R Willis, M Smikle, O Heslop, N Bodonaik, M Thame, U Kumar, M Aung, A Kellier, S Drysdale, V Leon
BACKGROUND: Pneumococcal serotypes circulating in any population vary over time and between countries and impacts the effectiveness of pneumococcal vaccination. OBJECTIVE: This study investigated the epidemiology of pneumococcal disease in Jamaica. METHODS: Streptococcus pneumoniae isolates (n= 349) along with demographic and clinical information were collected from patients presenting at the 4 major hospitals in Jamaica over a 2-year period...
May 16, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29843231/tnf-%C3%AE-308g-a-gene-polymorphism-in-bullous-pemphigoid-and-alopecia-areata
#5
Hamideh Moravvej, Pardis-Sadat Tabatabaei-Panah, Elaheh Ebrahimi, Nafiseh Esmaeili, Sayyed Mohammad Hossein Ghaderian, Ralf J Ludwig, Reza Akbarzadeh
BACKGROUND: TNF-α -308G/A polymorphism has been investigated in few studies for an association with susceptibility to bullous pemphigoid (BP) and alopecia areata (AA). Yet, these findings had so far not been independently replicated, and no data on a possible association of TNFα -308G/A polymorphism with these diseases in Iranian population were available. OBJECTIVES: In the present study, a possible effect of TNF-α -308G/A variation on susceptibility to BP or AA disease was evaluated...
May 11, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29689715/antibody-fusion-proteins-with-human-ribonucleases-1-to-8
#6
Xenia Wezler, Stefan Dübel, Thomas Schirrmann
ImmunoRNases combine tumor targeting by antibodies with the cytotoxic action of ribonucleases from the RNase A superfamily. This study investigated for the first time all catalytic active human RNase A family members (1 to 8) as effector components of antibody fusion proteins. ImmunoRNase fusion proteins were constructed using the CD30-specific bivalent recombinant scFv-Fc antibody SH313-B5. Production of the resulting entirely human immunoRNases 1 to 8 was done in mammalian cells by secretion of active forms...
April 10, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29689714/production-and-characterization-of-anti-human-igg-f-ab-2-antibody-fragment
#7
Zahra Valedkarimi, Hadi Nasiri, Leili Aghebati-Maleki, Jalal Abdolalizadeh, Mojghan Esparvarinha, Jafar Majidi
In present study an optimized protocol for the separation of antibodies into antigen-binding fragments F(ab')2 using pepsin digestion was investigated. The production of these fragments is a consequential step in the development of medical research, treatment and diagnosis. For production of polyclonal antibody rabbit received antigen in four steps. The rabbit serum at 1/128000 dilution showed high absorbance in reaction with human IgG at the designed ELISA method. Rabbit IgG was purified by Ion-Exchange Chromatography (IEC) method...
April 10, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29439321/knowledge-attitude-and-practice-of-hiv-aids-among-workers-at-china-first-highway-engineering-company-at-bilibila-sokota-road-project-sokota-ethiopia
#8
Mebratu Tarekegne, Addis Adera, Kalab Haile, Derara Guyo
OBJECTIVE: The aim of this study was to assess Bilbila Sokota Road Project workers' knowledge, attitude and practice on HIV/AIDS in China first highway engineering Company. METHODS: A cross sectional Survey was conducted among workers in China first high way engineering Company at Bilbila Sokota road project, Sokota, Ethiopia. Fifty-five workers were taken from project site/company. Data was collected using a validated self-administrated standardized questionnaire on Knowledge, attitude and practice including behavioral change regarding HIV/AIDS...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29439320/of-patents-and-patent-disputes-the-tnf%C3%AE-patent-files-part-2-enbrel-remicade-cimzia-and-simponi
#9
Ulrich Storz
This article is the second part of a trilogy that discusses IP issues related to anti-Tumor Necrosis factor α (TNFα) biologics. TNFα is the world's most valuable target, with accumulated sales of TNFα biologics of 34 bn USD in 2014. While in the first part of this trilogy, Humira was discussed, this second parts discusses the patent strategies of Enbrel, Remicade, Cimzia and Simponi.
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29171990/development-of-nanoparticle-adjuvants-to-potentiate-the-immune-response-against-diphtheria-toxoid
#10
Fatimah M Alshanqiti, Saad Berki Al-Masaudi, Ahmed M Al-Hejin, Nawal Abd El-Baky, Elrashdy M Redwan
BACKGROUND: Over the years, diphtheria was known as contagious fatal infection caused by Corynebacterium diphtheria that affects upper respiratory system. The spread of diphtheria epidemic disease is best prevented by vaccination with diphtheria toxoid vaccine. Aluminum adjuvants were reported to stimulate the immune responses to killed and subunit vaccines. OBJECTIVE: Our study aimed to minimize adjuvant particles size, to gain insight of resulting immunity titer and impact on immune response antibody subtypes...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29036807/obtaining-and-characterization-of-monoclonal-antibodies-against-recombinant-extracellular-domain-of-human-epidermal-growth-factor-receptor-2
#11
Nurgul Sarina, Sailau Abeldenov, Aigerim Turgimbayeva, Assylbek Zhylkibayev, Yerlan Ramankulov, Bekbolat Khassenov, Saule Eskendirova
Human epidermal growth factor receptor 2 (HER2) is an important biomarker for detection and treatment of different types of cancers such as breast, ovarian, stomach cancer. In this study, we developed a monoclonal antibody against the extracellular domain (ECD) of HER2 biomarker of breast cancer. For this purpose, the ECD-HER2 gene was amplified and cloned into an expression vector. Gene was generated in Escherichia coli BL21 (DE3) strain for expression of recombinant protein. The expressed protein was separated by SDS-PAGE and detected by anti-his monoclonal antibody in immunoblotting...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29036806/pritumumab-the-first-therapeutic-antibody-for-glioma-patients
#12
Ivan Babic, Elmar Nurmemmedov, Venkata M Yenugonda, Tiffany Juarez, Natsuko Nomura, Sandeep C Pingle, Mark C Glassy, Santosh Kesari
Immunotherapy is now at the forefront of cancer therapeutic development. Gliomas are a particularly aggressive form of brain cancer for which immunotherapy may hold promise. Pritumumab (also known in the literature as CLNH11, CLN-IgG, and ACA-11) was the first monoclonal antibody tested in cancer patients. Pritumumab is a natural human monoclonal antibody developed from a B lymphocyte isolated from a regional draining lymph node of a patient with cervical carcinoma. The antibody binds ecto-domain vimentin on the surface of cancer cells...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29036805/determining-the-igm-and-igg-antibodies-titer-against-hsv1-hsv2-and-cmv-in-the-serum-of-schizophrenia-patients
#13
Masome Mohagheghi, Mohammad Mahdi Eftekharian, Mohammad Taheri, Mohammad Yousef Alikhani
Schizophrenia is a destructive clinical syndrome with diverse mental pathologies. Different mechanisms and factors have a role in this disease. A possible mechanism is that teratogenic viruses cause brain changes and results in the disease appearance. The schizophrenia patients were diagnosed by psychologists and with the consent of patients, five CC of venous blood was drawn. Than Serum samples were isolated and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2) and cytomegalovirus (CMV) were quantified by ELISA sandwich kit...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/28582853/investigating-the-exon-6-sequence-changes-of-interleukin-7-receptor-a-il7ra-gene-in-patients-with-relapsing-remitting-multiple-sclerosis
#14
Mohammad Taheri, Arezou Sayad
BACKGROUND: Interleukin 7 receptor alpha (IL7RA) gene that encodes a subunit of IL7 receptor has been reported to be associated with different immunologic disease. OBJECTIVE: Multiple Sclerosis (MS) patients have shown an aberrant blood level of soluble form of IL7R protein. The genomic changes in the sequence of this gene have been suggested to be correlated with its altered splicing specially, variants in the exon 6 of the gene have been reported to influence the maintenance or skipping of this exon and control the soluble or insoluble form of the final product...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/28582852/human-anti-lipopolysaccharid-lps-antibodies-against-legionella-with-high-species-specificity
#15
Philipp Kuhn, Stefanie Thiem, Michael Steinert, Duncan Purvis, Veronika Lugmayr, Ulrich Treutlein, Lutz Plobner, Robert-Matthias Leiser, Michael Hust, Stefan Dübel
Legionella are Gram-negative bacteria that are ubiquitously present in natural and man-made water reservoirs. When humans inhale aerosolized water contaminated with Legionella, alveolar macrophages can be infected, which may lead to a life-threatening pneumonia called Legionnaires' disease. Due to the universal distribution of Legionella in water and their potential threat to human health, the Legionella concentration in water for human use must be strictly monitored, which is difficult since the standard detection still relies on lengthy cultivation and analysis of bacterial morphology...
July 19, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28505966/on-the-antigen-antibody-interaction-a-thermodynamic-consideration
#16
Philip J G M Voets
Despite its relevance to many biomedical fields, relatively little effort has been put into a comprehensible quantitative description of the effect of reaction temperature on the interaction between antigens and their antibodies. In this article, a novel, straightforward mathematical model is proposed, which aims to describe the effect of temperature on antigen-antibody kinetics. The model proposed in this article could hopefully provide clinicians, immunologists, and biochemists with an improved insight into the kinetic effect of fluctuations in reaction temperature on antigen-antibody-dependent processes and therefore into the kinetics of the humoral adaptive immune response...
July 19, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28505965/determining-the-igm-and-igg-antibody-titer-against-cmv-and-helicobacter-pylori-in-the-serum-of-multiple-sclerosis-patients-comparing-to-the-control-group-in-hamadan
#17
Masome Afiati Salim, Mohammad Mahdi Eftekharian, Mohammad Taheri, Mohammad Yousef Alikhani
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that disables central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female. METHODS: Serum samples were isolated and frozen at -70∘C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit. RESULTS: The results showed that IgG antibody average value against cytomegalovirus in the blood of multiple sclerosis patients not only decreased but also was significant statistically (p< 0...
July 19, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28482631/keyword-index-volume-25-2016-2017
#18
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28482629/this-issue-is-dedicated-to-george-klein-1925-2016-a-giant-creative-and-stimulating-scientist-of-infinite-knowledge-friend-and-mentor
#19
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28128761/keyword-index-volume-24-2015-2016
#20
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: Human Antibodies
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