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Human Antibodies

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https://www.readbyqxmd.com/read/28505966/on-the-antigen-antibody-interaction-a-thermodynamic-consideration
#1
Philip J G M Voets
Despite its relevance to many biomedical fields, relatively little effort has been put into a comprehensible quantitative description of the effect of reaction temperature on the interaction between antigens and their antibodies. In this article, a novel, straightforward mathematical model is proposed, which aims to describe the effect of temperature on antigen-antibody kinetics. The model proposed in this article could hopefully provide clinicians, immunologists, and biochemists with an improved insight into the kinetic effect of fluctuations in reaction temperature on antigen-antibody-dependent processes and therefore into the kinetics of the humoral adaptive immune response...
May 5, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28505965/determining-the-igm-and-igg-antibody-titer-against-cmv-and-helicobacter-pylori-in-the-serum-of-multiple-sclerosis-patients-comparing-to-the-control-group-in-hamadan
#2
Masome Afiati Salim, Mohammad Mahdi Eftekharian, Mohammad Taheri, Mohammad Yousef Alikhani
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that disables Central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female. METHODS: Serum samples were isolated and frozen at -70°C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit. RESULTS: The results showed that IgG antibody average value against cytomegalovirus in the blood of multiple sclerosis patients not only decreased but also was significant statistically (p< 0...
May 5, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28282804/ifnar1-expression-level-in-iranian-multiple-sclerosis-patients-treated-with-ifn-b
#3
Arezou Sayad, Mohsen Khakzad Kelarijani, Elham Sajjadi, Mohammad Taheri
BACKGROUND: Multiple sclerosis (MS) as an auto-immune disease is an inflammatory, demyelinating disease of the central nervous system. Certain genes have shown to be involved in the initiation of MS but the specific role of some of them, e.g. IFNAR1 has not been identified in certain populations yet. OBJECTIVE: The IFNAR1 as a type I membrane protein shapes one of the two chains of a receptor for interferons alpha and beta. METHODS: To find out how IFNAR1 functions in the Iranian population, the researchers compared the expression level of this gene in relapsing-remitting MS (RR-MS) samples with normal individuals...
March 3, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28269763/development-of-high-affinity-monoclonal-antibody-using-cd44-overexpressed-cells-as-a-candidate-for-targeted-immunotherapy-and-diagnosis-of-acute-myeloid-leukemia
#4
Amir Amanzadeh, Fatemeh Heidarnejad, Meghdad Abdollahpour-Alitappeh, Vahid Molla Kazemiha, Shamsi Yari, Ali Reza Hadizadeh Tasbiti, Mahdi Habibi Anbouhi, Mohsen Abolhassani, Mohammad Ali Shokrgozar
AIM: CD44s antigens have been suggested as an efficient biomarker for cancer stem cells. Current study aimed to develop a hybridoma that producing a high affinity murine anti-human CD44 monoclonal antibody for early diagnostic laboratory tests of some cancer. MATERIALS AND METHODS: To make hybridoma against CD44, mice were immunized with MDA-MB-468 cells. Resulted hybridomas using three culture media were screened by indirect ELISA, then cloned by limiting dilution, and isotype was determined after obtaining ascitic fluid and antibody purification...
February 25, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28269762/cloning-and-molecular-characterization-of-the-cdnas-encoding-the-variable-regions-of-an-anti-cd20-monoclonal-antibody
#5
Dariush Shanehbandi, Jafar Majidi, Tohid Kazemi, Behzad Baradaran, Leili Aghebati-Maleki
BACKGROUND: CD20-based targeting of B-cells in hematologic malignancies and autoimmune disorders is associated with outstanding clinical outcomes. Isolation and characterization of VH and VL cDNAs encoding the variable regions of the heavy and light chains of monoclonal antibodies (MAb) is necessary to produce next generation MAbs and their derivatives such as and bispecific antibodies (bsAb) and single-chain variable fragments (scFv). OBJECTIVE: This study was aimed at cloning and characterization of the VH and VL cDNAs from a hybridoma cell against the CD20 antigen...
February 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28482631/keyword-index-volume-25-2016-2017
#6
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28482630/author-index-volume-25-2016-2017
#7
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28482629/this-issue-is-dedicated-to-george-klein-1925-2016-a-giant-creative-and-stimulating-scientist-of-infinite-knowledge-friend-and-mentor
#8
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28128761/keyword-index-volume-24-2015-2016
#9
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28128760/author-index-volume-24-2015-2016
#10
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28269761/treatment-with-a-recombinant-human-igm-that-recognizes-psa-ncam-preserves-brain-pathology-in-mog-induced-experimental-autoimmune-encephalomyelitis
#11
Hernan Nicolas Lemus, Arthur E Warrington, Aleksandar Denic, Bharath Wootla, Moses Rodriguez
A single peripheral dose of CNS-binding IgMs promote remyelination and preserve axons in a number of animal models of neurologic disease. A myelin-binding recombinant human IgM (rHIgM22) is presently in a safety trial in MS patients following an acute MS exacerbation. rHIgM22 (directed against oligodendrocytes) or rHIgM12 (directed against neurons) were administered to mice with MOG-induced experimental autoimmune encephalomyelitis (EAE) with study endpoints: clinical deficits and brain and spinal cord pathology...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28222501/a-molecular-case-control-study-of-association-of-hnf1a-gene-polymorphisms-rs2259816-and-rs7310409-with-risk-of-coronary-artery-disease-in-iranian-patients
#12
Samaneh Adami Barzi, Sayyed Mohammad Hossein Ghaderian, Zahra Noormohammadi
BACKGROUND: Coronary artery disease (CAD) is the one of the most common heart diseases, being the main factor of mortality and morbidity worldwide. CAD has been known as a multifactorial disease and its progression depends on genetic and environmental factors. Numerous studies have shown evidence for association between 12q24.3 locus and CAD. OBJECTIVES: In the present study, the association of two HNF1A polymorphisms, rs2259816 and rs7310409, located on 12q24.3 locus with CAD was investigated in Iranian patients...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28211808/human-monoclonal-antibodies-in-the-clinic-novel-insights-into-the-choice-of-specific-targets
#13
Michael Steinitz
No abstract text is available yet for this article.
2017: Human Antibodies
https://www.readbyqxmd.com/read/28128766/isolation-and-characterization-of-anti-ror1-single-chain-fragment-variable-antibodies-using-phage-display-technique
#14
Leili Aghebati-Maleki, Vahid Younesi, Farhad Jadidi-Niaragh, Behzad Baradaran, Jafar Majidi, Mehdi Yousefi
Receptor tyrosine kinase-like orphan receptor (ROR1) belongs to one of the families of receptor tyrosine kinases (RTKs). RTKs are involved in the various physiologic cellular functions including proliferation, migration, survival, signaling and differentiation. Several RTKs are deregulated in various cancers implying the targeting potential of these molecules in cancer therapy. ROR1 has recently been shown to be expressed in various types of cancer cells but not in normal adult cells. Hence a molecular inhibitor of extracellular domain of ROR1 that inhibits ROR1-cell surface interaction is of great therapeutic importance...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28085017/curing-tumor-bearing-mice-by-shifting-a-th2-to-a-th1-anti-tumor-response
#15
Karl Erik Hellstrom, Min Dai, Ingegerd Hellstrom
Over the past several years remarkable therapeutic responses have been obtained with immunomodulatory monoclonal antibodies (mAbs), both in mice \cite{10,18,20,48,54,61} and human cancer patients \cite{1,3,14,28,30,39,80}. However, complete regressions and cures are infrequent and not predictable and some tumor types respond much worse than others. As an attempt to increase curability, we have investigated in mouse models the therapeutic efficacy of several mAb combinations, focusing on anti-PD-1/CTLA-4/CD137 and anti-PD-1/CTLA-4/CD137/CD19, and we have also combined mAbs with the chemotherapeutic drug cisplatin...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28085016/harnessing-co-stimulatory-tnf-receptors-for-cancer-immunotherapy-current-approaches-and-future-opportunities
#16
Jeremy D Waight, Randi B Gombos, Nicholas S Wilson
Co-stimulatory tumor necrosis factor receptors (TNFRs) can sculpt the responsiveness of T cells recognizing tumor-associated antigens. For this reason, agonist antibodies targeting CD137, CD357, CD134 and CD27 have received considerable attention for their therapeutic utility in enhancing anti-tumor immune responses, particularly in combination with other immuno-modulatory antibodies targeting co-inhibitory pathways in T cells. The design of therapeutic antibodies that optimally engage and activate co-stimulatory TNFRs presents an important challenge of how to promote effective anti-tumor immunity while avoiding serious immune-related adverse events...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28035916/the-paired-receptors-tigit-and-dnam-1-as-targets-for-therapeutic-antibodies
#17
Natan Stein, Pinchas Tsukerman, Ofer Mandelboim
One of the most exciting fields in modern medicine is immunotherapy, treatment which looks to harness the power of the immune system to fight disease. A particularly effective strategy uses antibodies designed to influence the activity levels of the immune system. Here we look at two receptors - TIGIT and DNAM-1 - which bind the same ligands but have opposite effects on immune cells, earning them the label `paired receptors'. Importantly, natural killer cells and cytotoxic T cells express both of these receptors, and in certain cases their effector functions are dictated by TIGIT or DNAM-1 signaling...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28035915/modulators-of-igg-penetration-through-the-blood-brain-barrier-implications-for-alzheimer-s-disease-immunotherapy
#18
John M Finke, William A Banks
This review serves to highlight approaches that may improve the access of antibody drugs to regions of the brain affected by Alzheimer's Disease. While previous antibody drugs have been unsuccessful in treating Alzheimer's disease, recent work demonstrates that Alzheimer's pathology can be modified if these drugs can penetrate the brain parenchyma with greater efficacy. Research in antibody blood-brain barrier drug delivery predominantly follows one of three distinct directions: (1) enhancing influx with reduced antibody size, addition of Trojan horse modules, or blood-brain barrier disruption; (2) modulating trancytotic equilibrium and/or kinetics of the neonatal Fc Receptor; and (3) manipulation of antibody glycan carbohydrate composition...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28035914/antibody-mimicry-receptors-and-clinical-applications
#19
Alberto L Horenstein, Antonella Chillemi, Valeria Quarona, Andrea Zito, Valentina Mariani, Angelo C Faini, Fabio Morandi, Ilaria Schiavoni, Clara Maria Ausiello, Fabio Malavasi
This review focuses on the concept of antibodies acting as receptor agonists and antagonists, and on the potential relevance of this notion in applied medicine. Antibodies are composed of three functional units: two antigen-binding fragments (Fabs) that confer antigen specificity and one constant fragment (Fc) linking antibodies to immune effector functions. The proof-of-concept that large amounts of highly specific and homogeneous antibodies could be produced was provided in 1975 by César Milstein and Georges Köhler...
2017: Human Antibodies
https://www.readbyqxmd.com/read/28009328/seroprevalence-and-diagnosis-of-hiv-hbv-hcv-and-syphilis-infections-among-blood-donors
#20
Tadesse Bekele Tafesse, Addis Adera Gebru, Semgne Gobalee, Gosaye Degu Belay, Molla Teferi Belew, Demelash Ataro, Belay Ali Ebrahim, Getachew Mekonnon Shebeshi, Yonas Yimam
BACKGROUND: Blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. However, it is associated with certain risks which can lead to adverse consequences that may cause acute or delayed complications and bring the risk of transfusion-transmissible infections including HIV, Hepatitis B & C and Syphilis. So, there might be a fatal risk instead of life saving. This paper aims to provide a comprehensive and reliable tabulation of available data on seroprevalence and diagnosis of HIV, HBV, HCV and Syphilis infections among blood donors...
2017: Human Antibodies
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