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Human Antibodies

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https://www.readbyqxmd.com/read/27911288/the-effect-of-base-transceiver-station-waves-on-some-immunological-and-hematological-factors-in-exposed-persons
#1
Mohammad Taheri, Ghodratollah Roshanaei, Jamileh Ghaffari, Samira Rahimnejad, Behzad Nazel Khosroshahi, Mohsen Aliabadi, Mohammad Mahdi Eftekharian
BACKGROUND: Since the number of mobile subscribers has significantly increased in recent years, the installation and deployment of Base Transceiver Station (BTS) antennas sending and receiving signals has become common and inevitable in different regions. OBJECTIVE: In this study, we have tried to evaluate the effect of the waves on some immunological and hematological parameters in exposed individuals. In this study, the exposed and non-exposed individuals were used as the test and control groups, respectively...
November 25, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27858706/adjuvants-for-clostridium-tetani-and-clostridium-diphtheriae-vaccines-updating
#2
Fatimah M Alshanqiti, Saad B Al-Masaudi, Ahmed M Al-Hejin, Elrashdy M Redwan
It's known that diphtheria and tetanus are a contagious lethal disease over the years, they caused by pathogenic microbes corynebacterium diphtheria and Clostridium tetani, respectively. The diseases result from the production of bacterial toxin. Vaccination with bacterial toxoid vaccines adsorbed on particulates adjuvants still are the best way to prevent this epidemic diseases from spread. The particulate vaccines have been shown to be more efficient than soluble one for the induction of the immune responses...
November 4, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27858705/epitope-analysis-of-japanese-cedar-pollen-allergen-cry-j2-with-a-human-igm-class-monoclonal-antibody-404-117
#3
Seiya Chiba, Haruka Yokoyama, Ayane Kumazawa, Michie Shimmoto, Yasunori Naganawa, Hiroshi Shinmoto
Japanese cedar pollen allergen Cry j2 is a causal allergen of seasonal pollinosis in Japan. To analyze B cell epitopes of Cry j2, we established two human-mouse hybridomas secreting IgM class human monoclonal antibodies to Cry j2. A pin-peptide enzyme-linked immunosorbent assay with synthesized icosa peptides showed that 404-117 monoclonal antibody bound to peptides #11-13 with cry j2 amino acid sequence of 101F-L140. Detailed analysis with octa peptides and alanine substituted peptides indicated that an amino acid sequence of 118FKVD121 was an essential for antibody binding...
November 4, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27792008/of-patents-and-patent-disputes-the-tnf%C3%AE-patent-files-part-1-humira
#4
Ulrich Storz
This article discusses the patent strategy underlying the world's best selling drug, AbbVie's Humira®. Despite a non-optiimal starting position, AbbVie has established an extensive portfolio to fend off biosimilar competition. This article is the first part of a trilogy that discusses IP issues related to anti-Tumor Necrosis factor α (TNFα) biologics.
October 21, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27792007/single-nucleotide-polymorphisms-in-the-foxp3-gene-are-associated-with-increased-risk-of-relapsing-remitting-multiple-sclerosis
#5
Mohammad Mahdi Eftekharian, Arezou Sayad, Mir Davood Omrani, Masoud Sabouri Ghannad, Rezvan Noroozi, Mehrdokht Mazdeh, Reza Mirfakhraie, Abolfazl Movafagh, Ghodratollah Roshanaei, Tahereh Azimi, Hidetoshi Inoko, Mohammad Taheri
BACKGROUND: Although Multiple Sclerosis (MS) is an autoimmune multifactorial disease with unknown etiology, various genetic and environmental factors are known to contribute to the pathogenesis of the disease. OBJECTIVE: Recent studies have confirmed that the suppressive function of regulatory T cells (T (reg)) is impaired in MS patients and that the FOXP3 gene is a crucial transcription factor in the regulation of CD4+CD25+FOXP3+ Treg cells. Polymorphisms in the promoter region of the FOXP3 gene may alter the gene expression level and, therefore, contribute to the disease susceptibility...
October 21, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27792006/construction-of-human-anti-tetanus-single-chain-variable-fragment-applying-symplex-technology
#6
Laya Esmati, Jalil Fallah Mehrabadi, Masoumeh Bazaz, Hamideh Rouhani Nejad
BACKGROUND: Human monoclonal antibodies are important molecules in clinical research. Current Limitations of mAb technologies namely instability of immortalized B-cell line and probability of forming unusual VH-VL pairs in phage-display method led to mAbs technology based on single plasma cell called ``SYMPLEX''. OBJECTIVE: In this method, cognate VH and VL fragments generated from individual antibody genes exactly the same as natural ones. METHODS: PBMCs of whole blood of an immunized candidate was used as a resource of rearranged Ab genes...
October 20, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27792005/down-regulation-of-cyp27b1-gene-expression-in-iranian-patients-with-relapsing-remitting-multiple-sclerosis
#7
Zahra Rezaie, Mohammad Taheri, Leila Kohan, Arezou Sayad
BACKGROUND: Multiple sclerosis (MS) as a complex neurological disease can be due to vitamin D deficiency. CYP27B1 is referred to as a vitamin D metabolizing enzyme. MATERIALS AND METHODS: This study compared the expression level of CYP27B1 in Relapsing-Remitting MS (RRMS) patients with normal individuals in Iran. The RNA was extracted from 50 RRMS patients and 50 normal controls. Quantitative RT-PCR was adopted to measure the expression level of CYP27B1 gene. RESULTS: The expression level of CYP27B1gene was significantly lower in the RRMS patients than their normal counterparts (P value = 0...
October 14, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27689613/increased-expression-ratio-of-matrix-metalloproteinase-9-mmp9-and-tissue-inhibitor-of-matrix-metalloproteinase-timp-1-rna-levels-in-iranian-multiple-sclerosis-patients
#8
Marzieh Khoshbin Nazdik, Mohammad Taheri, Mir Davood Omrani, Elham Sajjadi, Shahram Arsang-Jang, Zeinab Kazaei Koohpar, Hidetoshi Inoko, Arezou Sayad
OBJECTIVES: Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system (CNS) with unknown immunopathogenic mechanisms. Matrix metalloproteinase-9 (MMP-9) facilitates T-cell migration into the CNS while the tissue inhibitor matrix metalloproteinase-1 (TIMP-1) inhibits MMP-9 actions. The aim of this study was to evaluate the expression of TIMP-1 RNA and MMP-9/TIMP-1 RNA ratio in blood cells of Iranian patients with relapsing-remitting multiple sclerosis (RRMS) treated with IFNb...
September 22, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472870/investigation-of-the-correlation-between-some-immune-system-and-biochemical-indicators-in-patients-with-type-2-diabetes
#9
Mohammad Mahdi Eftekharian, Jamshid Karimi, Mojgansadat Safe, Ahmad Sadeghian, Shiva Borzooei, Ehsan Siahpoushi
AIMS/INTRODUCTION: Since changes in some immune system indicators such as leukocyte count and neutrophil to lymphocyte ratio in the blood and Inflammation is directly in relation with the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis, measuring these indicators in patients with type 2 diabetes and comparing them with control group can be a suitable indicator of Inflammation and prognosis of the disease. MATERIALS AND METHODS: The current study was done on 75 patients with type 2 diabetes and 72 healthy individuals as patient and healthy group respectively...
June 8, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472869/frequency-of-viral-infections-and-environmental-factors-in-multiple-sclerosis
#10
Mohammad Mahdi Eftekharian, Masoud Sabouri Ghannad, Mohammad Taheri, Ghodratollah Roshanaei, Mehrdokht Mazdeh, Mehrnoosh Musavi, Mona Bahmani Hormoz
OBJECTIVES: Multiple sclerosis (MS) is a complicated disease which occurs due to relationship between genes and environmental factors that causes tissue damage by autoimmune mechanisms.We investigated and illustrated the hypotheses correlated to the evidence of several putative environmental risk factors for MS onset and progression in this part of Iran. MATERIALS AND METHODS: Univariate logistic regression was used to detect the effects of environmental factors on the risk of MS...
June 8, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472868/high-resolution-analysis-of-the-b-cell-repertoire-before-and-after-polyethylene-glycol-fusion-reveals-preferential-fusion-of-rare-antigen-specific-b-cells
#11
Axel R S X Dubois, Jean-Philippe Buerckert, Regina Sinner, William J Faison, Anne M Molitor, Claude P Muller
OBJECTIVE: The hybridoma technology is one of the most important advances in clinical immunology. Little is known about the differences between the antibodies produced during the in vivo immune response and those recovered in hybridoma libraries. Here, we investigate a potential fusion bias inherent to the hybridoma production process. METHODS: Transgenic rats carrying human Ig heavy and light chain loci were immunized with measles virus (MV) to generate human mAbs...
June 8, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472871/trail-gene-expression-analysis-in-multiple-sclerosis-patients
#12
Mohammad Taheri, Shirin Nemati, Abolfazl Movafagh, Mohammad Saberi, Reza Mirfakhraie, Mohammad Mahdi Eftekharian, Shahram Arsang-Jang, Amir Rezagholizadeh, Arezou Sayad
BACKGROUND: Multiple sclerosis (MS) as an autoimmune disorder in which the insulating covers of neurons in the Central Nervous System are destructed. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an immunomodulatory molecule to protect against T cells hyper activation. METHODS: In this Case-control study, we compare TRAIL gene expression in peripheral blood between 50 relapse remitting MS patients and 50 healthy controls by TaqMan Real time PCR...
May 20, 2016: Human Antibodies
https://www.readbyqxmd.com/read/27472867/keyword-index-volume-23-2014-2015
#13
(no author information available yet)
No abstract text is available yet for this article.
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472866/author-index-volume-23-2014-2015
#14
(no author information available yet)
No abstract text is available yet for this article.
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472865/design-and-construction-of-immune-phage-antibody-library-against-tetanus-neurotoxin-production-of-single-chain-antibody-fragments
#15
Sanam Sadreddini, Mehrnosh Seifi-Najmi, Babollah Ghasemi, Hossein Samadi Kafil, Vahideh Alinejad, Sevil Sadreddini, Vahid Younesi, Farhad Jadidi-Niaragh, Mehdi Yousefi
BACKGROUND: Tetanus neurotoxin (TeNT) is composed of a light (LC) and heavy chain (HC) polypeptides, released by anaerobic bacterium Clostridium tetani and can cause fatal life-threatening infectious disease. Toxin HC and LC modules represents receptor binding and zinc metalloprotease activity, respectively. The passive administration of animal-derived antibodies against tetanus toxin has been considered as the mainstay therapy for years. However, this treatment is associated with several adverse effects due to the presence of anti-isotype antibodies...
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472864/licensed-monoclonal-antibodies-and-associated-challenges
#16
Amjad Hayat Khan, Esmaeil Sadroddiny
Monoclonal antibodies (mAbs) are the leading class of targeted therapeutics and remarkably effective in addressing autoimmune diseases, inflammations, infections, and various types of cancer. Several mAbs approved by US food and drug administration (FDA), are available on the market and a number are pending for approval. Luckily, FDA approved mAbs have played a pivotal role in the treatment and prevention of lethal diseases. However, claiming that licensed mAbs are 100% safe is still debatable, because infections, malignancies, anaphylactoid, and anaphylactic reactions are the more frequently associated adverse events...
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472863/prevalence-of-hepatitis-b-surface-antigen-among-biomedical-students-of-african-descent-in-usmanu-danfodiyo-university-sokoto-nigeria
#17
A N Okwesili, F U Onuigwe, K Ibrahim, H Buhari, A Ibrahim, H Jafaru, O Erhabor, F U Onuigwe, Z Isaac, M H Ahmed, M Y Mainasara, T C Adias, M H Yeldu, E K Uko, F Udoma
BACKGROUND: Hepatitis B (HB) is a serious global public health problem that put health professionals particularly at risk. OBJECTIVE: The aim of this study was to investigate the prevalence of Hepatitis B surface antigen (HBsAg) among Biomedical Students of African descent attending Usmanu Danfodiyo University Sokoto in North-Western Nigeria. METHODS: The Onsite HBsAg (CTK Biotech, USA) was used to detect the presence of hepatitis B surface antigen...
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472862/the-emergence-of-antibody-therapies-for-ebola
#18
Andrew Hiatt, Michael Pauly, Kevin Whaley, Xiangguo Qiu, Gary Kobinger, Larry Zeitlin
This review describes the history of Ebola monoclonal antibody (mAb) development leading up to the recent severe Ebola outbreak in West Africa. The Ebola virus has presented numerous perplexing challenges in the long effort to develop therapeutic antibody strategies. Since the first report of a neutralizing human anti-Ebola mAb in 1999, the straightforward progression from in vitro neutralization resulting in in vivo protection and therapy has not occurred. A number of mAbs, including the first reported, failed to protect non-human primates (NHPs) in spite of protection in rodents...
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472861/glycosylation-of-plant-produced-human-antibodies
#19
Somanath Kallolimath, Herta Steinkellner
Human immunoglobulins circulate as highly heterogeneously glycosylated mixture of otherwise homogeneous protein backbones. A series of studies, mainly on IgG, have unequivocally proven that antibodies modulate their effector function through sugars present in the Fc domain. However, our limited technology in producing complex proteins such as antibodies, with defined glycan structures hamper in depths studies. This review introduces a plant based expression platform enabling engineering of antibody glycans...
December 23, 2015: Human Antibodies
https://www.readbyqxmd.com/read/27472860/plant-expression-systems-for-early-stage-discovery-and-development-of-lead-therapeutic-antibodies
#20
Vikram Virdi, Paloma Juarez, Ann Depicker
BACKGROUND: Antibodies for human clinical applications are predominantly produced in mammalian expression systems, with Chinese hamster ovary (CHO) cells being the gold standard. CHO cells are ideal for the manufacturing of the IgG class of antibodies, but not for the production of complex antibodies like secretory IgAs (SIgAs) and IgMs, which remain unavailable for clinical use. In contrast, plant seeds and leaves hold the promise to produce SIgAs, IgMs and similar complex antibody formats to scalable amounts...
December 23, 2015: Human Antibodies
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