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Clinical and Experimental Nephrology

Masayuki Tanemoto
No abstract text is available yet for this article.
November 13, 2018: Clinical and Experimental Nephrology
Anyi Wang, Takuo Hirose, Yusuke Ohsaki, Chika Takahashi, Emiko Sato, Ikuko Oba-Yabana, Satoshi Kinugasa, Yoshikazu Muroya, Sadayoshi Ito, Takefumi Mori
BACKGROUND: Tolvaptan is an effective treatment for polycystic kidney disease (PKD), but also causes unfortunate polyuria. Hydrochlorothiazide (HCTZ) has been shown to reduce urine volume in nephrogenic diabetes insipidus, raising the possibility that HCTZ could also be effective in reducing tolvaptan-induced polyuria. In this study, we examined the combined administration of HCTZ and tolvaptan. METHODS: Male PCK rats were divided into four groups of normal chow (Cont), normal chow plus tolvaptan, gavage HCTZ treatment, and tolvaptan + HCTZ...
November 13, 2018: Clinical and Experimental Nephrology
Yoshito Yamaguchi, Fuyuko Akagaki, Aya Nakamori, Toshihiro Sugiura
BACKGROUND: Renal resistive index (RI) calculated using renal Doppler ultrasonography (RDU) has recently been considered a clinically important indicator of renal outcome, survival, and systemic arteriosclerotic disorders. However, the cause of RI elevation remains unclear. The present study was an effort to first, identify the factors related to RI elevation, and second, understand the effect of renin-angiotensin system inhibitors (RAS-Is) on renal RI elevation. METHODS: We carried out this single-center case-control study among 100 CKD patients, recruited from outpatients who underwent RDU more than twice, at least a year apart...
November 13, 2018: Clinical and Experimental Nephrology
Sho Endo, Hitoshi Minakuchi, Tadashi Yoshida
No abstract text is available yet for this article.
November 12, 2018: Clinical and Experimental Nephrology
Makoto Araki, Koji Asano, Norihide Taniuchi
No abstract text is available yet for this article.
November 7, 2018: Clinical and Experimental Nephrology
Jin He, Xiaoyi Zhong, Lin Zhao, Hua Gan
BACKGROUND: Vascular calcification is common in chronic kidney disease (CKD) patients, while erythropoietin (EPO) is widely used in the treatment of renal anemia in CKD patients, whether there is a link between the two is still not clear. METHODS: The primary rat vascular smooth muscle cells (VSMCs) and CKD rats were treated with EPO and the calcium deposition was observed by alizarin red staining, von Kossa staining and calcium quantification. Activation of JAK2/STAT3/BMP-2 axis and NF-κB signaling pathways was investigated by Western blotting...
November 7, 2018: Clinical and Experimental Nephrology
Jakub Ruszkowski, Katarzyna A Lisowska, Małgorzata Pindel, Zbigniew Heleniak, Alicja Dębska-Ślizień, Jacek M Witkowski
BACKGROUND: Immunoglobulin A nephropathy (IgAN), the most frequent cause of primary glomerulonephritis worldwide, is an autoimmune disease with complex pathogenesis. In this review, we focus on T cells and summarize knowledge about their involvement in pathophysiology and treatment of IgAN METHODS: We reviewed the literature for (1) alterations of T cell subpopulations in IgAN, (2) experimental and clinical proofs for T cells' participation in IgAN pathogenesis, (3) clinical correlations with T cell-associated alterations, and (4) influence of drugs used in IgAN therapy on T cell subpopulations...
November 7, 2018: Clinical and Experimental Nephrology
Kunihiro Yamagata, Joichi Usui, Hitoshi Sugiyama, Shoichi Maruyama, Ichiei Narita
No abstract text is available yet for this article.
October 31, 2018: Clinical and Experimental Nephrology
Hideo Okonogi, Tetsuya Kawamura, Kensuke Joh, Kentaro Koike, Yoichi Miyazaki, Makoto Ogura, Nobuo Tsuboi, Keita Hirano, Masato Matsushima, Takashi Yokoo, Satoshi Horikoshi, Yusuke Suzuki, Takashi Yasuda, Sayuri Shirai, Takanori Shibata, Motoshi Hattori, Yuko Akioka, Ritsuko Katafuchi, Akinori Hashiguchi, Satoshi Hisano, Akira Shimizu, Kenjiro Kimura, Shoichi Maruyama, Seiichi Matsuo, Yasuhiko Tomino
Histological classification is essential in the clinical management of immunoglobulin A nephropathy (IgAN). However, there are limitations in predicting the prognosis of IgAN based on histological information alone, which suggests the need for better prognostic models. Therefore, we defined a prognostic model by combining the grade of clinical severity with the histological grading system by the following processes. We included 270 patients and explored the clinical variables associated with progression to end-stage renal disease (ESRD)...
October 26, 2018: Clinical and Experimental Nephrology
Miki Shono, Maki Urushihara, Kenichi Suga, Noriko Watanabe, Takahiko Saijo, Ryuji Nakagawa, Shoji Kagami
BACKGROUND: We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development. METHODS: We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and 1 year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis...
October 23, 2018: Clinical and Experimental Nephrology
(no author information available yet)
No abstract text is available yet for this article.
October 22, 2018: Clinical and Experimental Nephrology
Tomomi Aizawa, Tadaatsu Imaizumi, Koji Hirono, Shojiro Watanabe, Koji Tsugawa, Hiroshi Tanaka
BACKGROUND: Chloroquine, an antimalarial agent, has been reported to prevent the risk of thrombosis and decrease renal damage in patients with systemic lupus erythematosus (SLE); however, its detailed mechanisms remain unclear. Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis and is involved in fibrin deposition in glomeruli. Since upregulation of glomerular Toll-like receptor 3 (TLR3) signaling reportedly plays a pivotal role in the pathogenesis of lupus nephritis (LN), we examined whether chloroquine affects TLR3-mediated expression of PAI-1 in cultured human glomerular endothelial cells (GECs)...
October 20, 2018: Clinical and Experimental Nephrology
Yoshihiko Imamura, Yasunori Takahashi, Toshihide Hayashi, Masateru Iwamoto, Rie Nakamura, Mikiko Goto, Kazuyo Takeba, Makoto Shinohara, Shun Kubo, Nobuhiko Joki
BACKGROUND: Comprehensive education about lifestyle, nutrition, medications and other types of treatment is important to prevent renal dysfunction in patients with chronic kidney disease (CKD). However, the effectiveness of multidisciplinary care on CKD progression has not been evaluated in detail. We aimed to determine whether multidisciplinary care at our hospital could help prevent worsening renal function associated with CKD. METHODS: A total of 150 pre-dialysis CKD outpatients accompanied (n = 68) or not (n = 82) with diabetes mellitus (DM) were enrolled into this study...
October 19, 2018: Clinical and Experimental Nephrology
Shinji Machida, Yugo Shibagaki, Tsutomu Sakurada
BACKGROUND: Chronic kidney disease (CKD) is a significant health problem in Japan, and prevention programs to slow disease progression are necessary. In this study, we evaluated the effectiveness of a 1-week inpatient education program, delivered during the predialysis stage of CKD, in slowing the deterioration in renal function over the subsequent 2 years, and identified factors influencing the program's effectiveness. METHODS: We retrospectively evaluated the estimated glomerular filtration rate (eGFR) of 105 consecutive patients who completed the program, at the following time points: 6 months prior to program initiation, at program initiation and, at 6, 12, 18, and 24 months after the program...
October 19, 2018: Clinical and Experimental Nephrology
Toru Fujii, Yuji Shiozaki, Hiroko Segawa, Shiori Nishiguchi, Ai Hanazaki, Miwa Noguchi, Ruri Kirino, Sumire Sasaki, Kazuya Tanifuji, Megumi Koike, Mizuki Yokoyama, Yuki Arima, Ichiro Kaneko, Sawako Tatsumi, Mikiko Ito, Ken-Ichi Miyamoto
BACKGROUND: The role of Na+ -dependent inorganic phosphate (Pi) transporters in the human kidney is not fully clarified. Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is caused by loss-of-function mutations in the IIc Na+ -dependent Pi transporter (NPT2c/Npt2c/NaPi-IIc) gene. Another Na+ -dependent type II transporter, (NPT2A/Npt2a/NaPi-IIa), is also important for renal Pi reabsorption in humans. In mice, Npt2c deletion does not lead to hypophosphatemia and rickets because Npt2a compensates for the impaired Pi reabsorption...
October 13, 2018: Clinical and Experimental Nephrology
Kunihiro Yamagata, Joichi Usui, Michio Nagata, Hitoshi Sugiyama, Ken-Ei Sada, Eri Muso, Masayoshi Harigai, Koichi Amano, Tatsuya Atsumi, Shouichi Fujimoto, Yukio Yuzawa, Masaki Kobayashi, Takao Saito, Takafumi Ito, Nobuhito Hirawa, Sakae Homma, Hiroaki Dobashi, Naotaka Tsuboi, Akihiro Ishizu, Yoshihiro Arimura, Hirofumi Makino, Seiichi Matsuo
BACKGROUND: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. METHODS: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies...
October 10, 2018: Clinical and Experimental Nephrology
Cihan Heybeli, Mehmet Ası Oktan, Serkan Yıldız, Hayri Üstün Arda, Mehtat Ünlü, Caner Çavdar, Aykut Sifil, Ali Çelik, Sülen Sarıoğlu, Taner Çamsarı
BACKGROUND: Glomerular immunoglobulin G deposition in patients with immunoglobulin A nephropathy (IgAN) has been shown to be associated with adverse renal outcomes. Clinical significance of mesangial immunoglobulin M (IgM) deposition in these patients remains to be proven. METHODS: One hundred patients who had a diagnosis of IgAN between 2001 and 2017 were enrolled. Patients were divided into two groups based on mesangial IgM deposition status. Groups were compared for demographic, clinical, and pathologic variables at baseline and in follow-up...
October 6, 2018: Clinical and Experimental Nephrology
Sayumi Watanabe, Tsuneo Konta, Kazunobu Ichikawa, Masafumi Watanabe, Kenichi Ishizawa, Yoshiyuki Ueno, Hidetoshi Yamashita, Takamasa Kayama, Isao Kubota
BACKGROUND: The association between salt intake and blood pressure levels is still inconclusive, and may be influenced by patient characteristics. We thus conducted a community-based cross-sectional study. METHODS: This study included 2297 subjects aged ≥ 40 years not on antihypertensive medication at the time of a health check-up. We examined the association between blood pressure levels and the estimated amount of 24-h urinary sodium excretion (e24hUNa) stratified by background characteristics...
October 6, 2018: Clinical and Experimental Nephrology
Xuemei Liu, Huifang Wang, Ruixia Ma, Leping Shao, Wei Zhang, Wei Jiang, Congjuan Luo, Tingting Zhai, Yan Xu
BACKGROUND: While the dose of allopurinol is limited in patients with chronic kidney disease (CKD), information is lacking concerning the efficacy, safety, and maintenance dose of febuxostat in Chinese patients with hyperuricemia and with CKD stages 3-5. METHODS: A single center, prospective cohort study was conducted in patients with CKD stages 3-5 and with hyperuricemia who had not yet begun to undergo renal replacement therapy. We enrolled 208 patients who were newly treated with febuxostat (n = 112) or allopurinol (n = 96) in this study...
October 5, 2018: Clinical and Experimental Nephrology
Terumasa Hayashi, Yukari Uemura, Michiko Kumagai, Masashi Kimpara, Hiroyuki Kanno, Yasuo Ohashi
BACKGROUND: Previous randomized-controlled trials have shown that targeting higher hemoglobin (Hb) levels using high dose of ESA in non-dialysis chronic kidney disease (NDCKD) patients resulted in poorer cardiovascular outcome; however, it remains unknown how high Hb levels achieved by ESA in clinical practice dose could affect renal outcome. METHODS: In a multicenter prospective observational study, Japanese NDCKD patients with an estimated glomerular filtration rate (eGFR) of ≥ 6 mL/min/1...
October 5, 2018: Clinical and Experimental Nephrology
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