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Clinical and Experimental Nephrology

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https://www.readbyqxmd.com/read/28741051/a-nationwide-prospective-cohort-study-of-patients-with-advanced-chronic-kidney-disease-in-japan-the-reach-j-ckd-cohort-study
#1
Junichi Hoshino, Kei Nagai, Hirayasu Kai, Chie Saito, Yukiko Ito, Koichi Asahi, Masahide Kondo, Kunitoshi Iseki, Chiho Iseki, Hirokazu Okada, Naoki Kashihara, Ichiei Narita, Takashi Wada, Christian Combe, Ronald L Pisoni, Bruce M Robinson, Kunihiro Yamagata
BACKGROUND: Epidemiology and outcomes of Japanese patients with advanced chronic kidney disease (CKD)-an estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73 m(2)-has remained largely unexamined. METHODS: We conducted a nationwide survey to determine the distribution of Japanese CKD patients, and are conducting a cohort study of these patients. A questionnaire eliciting details about facilities and their CKD practices was sent to all clinics/hospitals with nephrologists...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28741050/risk-factors-for-progression-of-chronic-kidney-disease-in-the-eppic-trials-and-the-effect-of-ast-120
#2
Gerald Schulman, Tomas Berl, Gerald J Beck, Giuseppe Remuzzi, Eberhard Ritz, Miho Shimizu, Mami Kikuchi, Yuko Shobu
BACKGROUND: Two randomized, double-blind, placebo-controlled trials (EPPIC-1 and EPPIC-2) investigated the efficacy and safety of AST-120, an oral spherical carbon adsorbent, in adults with chronic kidney disease (CKD). While the benefit of adding AST-120 to standard therapy was not supported by these trials, we performed a post hoc analysis to focus on CKD progression and to determine the risk factors for the primary endpoint in the EPPIC trial population. METHODS: In the EPPIC trials, patients were randomly assigned 1:1 to treatment with AST-120 or placebo...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28741049/the-assessment-of-renal-cortex-and-parenchymal-volume-using-automated-ct-volumetry-for-predicting-renal-function-after-donor-nephrectomy
#3
Yosuke Mitsui, Takuya Sadahira, Motoo Araki, Koichiro Wada, Ryuta Tanimoto, Yuichi Ariyoshi, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
BACKGROUND: Contrast-enhanced CT is necessary before donor nephrectomy and is usually combined with a Tc-99m-mercapto-acetyltriglycine (MAG3) scan to check split renal function (SRF). However, all transplant programs do not use MAG3 because of its high cost and exposure to radiation. We examined whether CT volumetry of the kidney can be a new tool for evaluating SRF. METHODS: Sixty-three patients underwent live donor nephrectomy. Patients without a 1.0 mm slice CT or follow-up for <12 months were excluded leaving 34 patients' data being analyzed...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28733945/abdominal-involvement-in-minimal-change-nephrotic-syndrome
#4
Saeko Kagaya, Tasuku Nagasawa
No abstract text is available yet for this article.
July 21, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28710535/pharmacological-inhibition-of-heparin-binding-egf-like-growth-factor-promotes-peritoneal-angiogenesis-in-a-peritoneal-dialysis-rat-model
#5
Zhenyuan Li, Hao Yan, Jiangzi Yuan, Liou Cao, Aiwu Lin, Huili Dai, Zhaohui Ni, Jiaqi Qian, Wei Fang
BACKGROUND: Molecular mechanisms of peritoneal dialysis (PD) ultrafiltration failure, peritoneal neo-angiogenesis, and fibrosis remain to be determined. We aimed to determine the role of heparin-binding EGF-like growth factor (HB-EGF) inhibition on angiogenesis of peritoneal membrane in a PD rat model. METHODS: 32 male Wistar rats were assigned into (1) control group; (2) uremic non-PD group: subtotal nephrectomy-induced uremic rats without PD; (3) uremic rats subjected to PD: uremic rats that were dialyzed with Dianeal(®) for 4 weeks; (4) CRM 197 group: dialyzed uremic rats were supplemented with CRM197, a specific HB-EGF inhibitor...
July 14, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28699033/low-white-blood-cell-count-is-independently-associated-with-chronic-kidney-disease-progression-in-the-elderly-the-ckd-route-study
#6
Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida
BACKGROUND: Elevated white blood cell (WBC) count is a well-known predictor of chronic kidney disease (CKD) progression. However, elderly patients commonly fail to develop a high WBC count in response to several diseased states and may instead present a low WBC count. Therefore, we hypothesized that low WBC count, in addition to high WBC count, is associated with CKD progression in the elderly. METHODS: We conducted a prospective cohort study using 3-year follow-up data from the CKD Research of Outcomes in Treatment and Epidemiology study...
July 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28699032/combined-cyclosporine-and-prednisolone-therapy-using-cyclosporine-blood-concentration-monitoring-for-adult-patients-with-new-onset-minimal-change-nephrotic-syndrome-a-single-center-pilot-randomized-trial
#7
Sayuri Shirai, Naohiko Imai, Shina Sueki, Katsuomi Matsui, Naoto Tominaga, Tsutomu Sakurada, Takashi Yasuda, Kenjiro Kimura, Yugo Shibagaki
BACKGROUND: Minimal change nephrotic syndrome (MCNS) responds well to steroids, but some patients show frequent relapses. Long-term steroid administration leads to various adverse effects. We previously reported the effectiveness in refractory nephrosis patients of administrating microemulsified CyA (ME-CyA) once before meals and setting the target value of the CyA blood concentration at 2 h after ME-CyA administration (C2) to 600-1200 ng/ml. On this trial we evaluate the effectiveness and safety of ME-CyA for suppressing relapse of adult new-onset MCNS patients using C2 monitoring...
July 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28699031/effectiveness-and-nephrotoxicity-of-a-2-year-medium-dose-of-cyclosporine-in-pediatric-patients-with-steroid-dependent-nephrotic-syndrome-determination-of-the-need-for-follow-up-kidney-biopsy
#8
Yoshiyuki Kuroyanagi, Yoshimitsu Gotoh, Katsuaki Kasahara, China Nagano, Naoya Fujita, Satoshi Yamakawa, Masaki Yamamoto, Asami Takeda, Osamu Uemura
BACKGROUND: High dose of cyclosporine (CyA) for ≥2 years in children with steroid-dependent nephrotic syndrome (SDNS) increases the risk for nephropathy. Considering this, risk can be lowered with lower doses of CyA; we evaluated the effects of a medium dose of CyA, with target serum level, C2, of 450 ng/ml, over a 2-year period of observation, to determine the need for follow-up kidney biopsy. METHODS: We retrospectively evaluated C2 levels in 38 patients (17 males, 5...
July 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28685235/pulmonary-nonsegmental-micronodules-in-a-patient-undergoing-hemodialysis
#9
Misato Tomura, Yosuke Hirakawa, Masaomi Nangaku
No abstract text is available yet for this article.
July 6, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28677097/erratum-to-the-cardiothoracic-ratio-and-all-cause-and-cardiovascular-disease-mortality-in-patients-undergoing-maintenance-hemodialysis-results-of-the-mbd-5d-study
#10
Hiroaki Ogata, Junji Kumasawa, Shingo Fukuma, Masahide Mizobuchi, Eriko Kinugasa, Masafumi Fukagawa, Shunichi Fukuhara, Tadao Akizawa
No abstract text is available yet for this article.
July 4, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28660446/rationale-and-design-of-observational-clinical-research-in-chronic-kidney-disease-patients-with-renal-anemia-renal-prognosis-in-patients-with-hyporesponsive-anemia-to-erythropoiesis-stimulating-agents-darbepoetin-alfa-brighten-trial
#11
Hideki Kato, Masaomi Nangaku, Hideki Hirakata, Takashi Wada, Terumasa Hayashi, Hiroshi Sato, Yasushi Yamazaki, Takao Masaki, Tatsuo Kagimura, Hiroyasu Yamamoto, Hiroki Hase, Masahiro Kamouchi, Enyu Imai, Kyoichi Mizuno, Manabu Iwasaki, Tadao Akizawa, Yoshiharu Tsubakihara, Shoichi Maruyama, Ichiei Narita
BACKGROUND: Renal anemia is an important complication in non-dialysis chronic kidney disease (CKD) patients as well as in dialysis patients. Although recombinant human erythropoietin has dramatically improved prognosis and quality of life in these patients, there have been issues among non-dialysis CKD patients who exhibit hyporesponsiveness to erythropoiesis-stimulating agent (ESA). The causes and definition of ESA hyporesponsiveness, as well as the incidence of renal and cardiovascular disease (CVD) events in such patients, are yet to be clarified...
June 28, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28660445/serum-adipocyte-fatty-acid-binding-protein-level-is-associated-with-arterial-stiffness-quantified-with-cardio-ankle-vascular-index-in-kidney-transplant-patients
#12
Yen-Cheng Chen, Bang-Gee Hsu, Chung-Jen Lee, Ching-Chun Ho, Guan-Jin Ho, Ming-Che Lee
BACKGROUND: Arterial stiffness is an established marker of cardiovascular risk and an independent predictor of cardiovascular disease (CVD) events and mortality in kidney transplant (KT) patients. Adipocyte fatty acid-binding protein (A-FABP), a novel adipokine, is positively associated with atherosclerosis. The present study evaluated the relationship between fasting circulating A-FABP and peripheral arterial stiffness using the cardio-ankle vascular index (CAVI) in KT patients. METHODS: Fasting blood samples were collected from 74 KT patients, and serum A-FABP levels were measured using an enzyme immunoassay...
June 28, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28660444/rituximab-in-primary-membranous-nephropathy-beyond-a-b-cell-centered-paradigm
#13
LETTER
Pasquale Esposito, Fabrizio Grosjean, Filippo Mangione, Maria Valentina Domenech, Teresa Rampino
No abstract text is available yet for this article.
June 28, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28653226/urinary-biomarkers-in-the-early-detection-and-follow-up-of-tubular-injury-in-childhood-urolithiasis
#14
Mehmet Taşdemir, Dilara Fuçucuoğlu, Suat Hayri Küçük, Meltem Erol, Özgül Yiğit, Ilmay Bilge
BACKGROUND: To investigate relationships among urinary biomarkers [kidney injury molecule-1 (KIM-1), N-acetyl-β-glucosaminidase (NAG)], neutrophil gelatinase-associated lipocalin (NGAL) levels and renal tubular injury in childhood urolithiasis. METHODS: Seventy children [36 girls, mean age: 7.3 ± 5.0 years (0.5-18.2)] with urolithiasis/microlithiasis and 42 controls [18 girls, mean age: 8.5 ± 3.8 years (0.9-16.2)] were included in this multicenter, controlled, prospective cohort study...
June 26, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28653225/erratum-to-impact-of-hemoglobin-levels-on-renal-and-non-renal-clinical-outcomes-differs-by-chronic-kidney-disease-stages-the-gonryo-study
#15
Tae Yamamoto, Mariko Miyazaki, Masaaki Nakayama, Gen Yamada, Masato Matsushima, Mistuhiro Sato, Toshinobu Sato, Yoshio Taguma, Hiroshi Sato, Sadayoshi Ito
No abstract text is available yet for this article.
June 26, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28643120/the-incidence-of-the-nephrotic-syndrome-in-childhood-in-germany
#16
Ingo Franke, Malik Aydin, Corinna Elke Llamas Lopez, Lisa Kurylowicz, Rainer Ganschow, Michael Lentze, Mark Born
BACKGROUND: The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS: An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT: The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay was 15.5 ± 11.2 days, with younger children remaining significantly longer in hospital. Steroid-resistance was more common in children ≥8 years (p = 0...
June 22, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28643119/home-based-versus-center-based-aerobic-exercise-on-cardiopulmonary-performance-physical-function-quality-of-life-and-quality-of-sleep-of-overweight-patients-with-chronic-kidney-disease
#17
Danilo Takashi Aoike, Flavia Baria, Maria Ayako Kamimura, Adriano Ammirati, Lilian Cuppari
BACKGROUND: The association between chronic kidney disease (CKD) and obesity can decrease the patients' cardiopulmonary capacity, physical functioning and quality of life. The search for effective and practical alternative methods of exercise to engage patients in training programs is of great importance. Therefore, we aimed to compare the effects of home-based versus center-based aerobic exercise on the cardiopulmonary and functional capacities, quality of life and quality of sleep of overweight non-dialysis-dependent patients with CKD (NDD-CKD)...
June 22, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28634773/development-and-validation-of-a-fall-risk-assessment-index-for-dialysis-patients
#18
Kenichi Kono, Yusuke Nishida, Hiroki Yabe, Yoshihumi Moriyama, Toshihiko Mori, Ryota Shiraki, Takashi Sato
BACKGROUND: Dialysis patients often have low physical performance due to uremic sarcopenia, protein energy wasting (PEW), and incidence intradialytic hypotension (IDH), which are indicated as risk factors for falling. The objective of this study was to develop a symptom-encompassing evaluation form to predict falls with high sensitivity for dialysis patients. METHODS: A total of 251 patients who had been receiving maintenance hemodialysis therapy three times a week were enrolled in the study...
June 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28634772/the-effect-of-desensitization-therapy-in-kidney-transplantation
#19
Yong Chul Kim, Mi-Yeon Yu, Jung Pyo Lee, Hajeong Lee, Sang-Il Min, Jongwon Ha, Yon Su Kim
BACKGROUND: Desensitization therapy may enable the patient to get allograft in sensitized recipient or solve the organ shortage in ABO-incompatible relationship in kidney transplantation (KT). However, the graft outcome and morbidity remains unclear. METHODS: We retrospectively analyzed 845 KT patients from January 2010 to February 2016 at Seoul National University Hospital. The patients were divided into three groups as follows: HLA-incompatible (HLAi) group, ABO-incompatible (ABOi) group, and control group...
June 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28634771/off-pump-versus-on-pump-coronary-surgery-in-patients-with-chronic-kidney-disease-a-meta-analysis
#20
Yushu Wang, Sui Zhu, Peijuan Gao, Juteng Zhou, Qing Zhang
BACKGROUND: Patients with chronic kidney disease (CKD) have worse adverse cardiovascular outcomes after coronary artery bypass grafting (CABG). However, the adverse cardiovascular outcomes between off-pump coronary artery bypass grafting (OPCAB) versus on-pump coronary artery bypass grafting (ONCAB) in these patients have been a subject of debate. METHODS: We undertook a comprehensive literature search of PubMed, Embase, and the Cochrane Library database to identify all relevant studies comparing techniques between OPCAB and ONCAB in CKD patients...
June 20, 2017: Clinical and Experimental Nephrology
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