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Clinical and Experimental Nephrology

Kyohei Ogawa, Keita Hirano
No abstract text is available yet for this article.
July 16, 2018: Clinical and Experimental Nephrology
Eiichiro Kanda, Naoki Kashihara, Kunihiro Matsushita, Tomoko Usui, Hirokazu Okada, Kunitoshi Iseki, Kenichi Mikami, Tetsuhiro Tanaka, Takashi Wada, Hirotaka Watada, Kohjiro Ueki, Masaomi Nangaku
No abstract text is available yet for this article.
July 13, 2018: Clinical and Experimental Nephrology
Yuko Hamasaki, Tetsuo Yamaguchi, Yusuke Takahashi, Junya Hashimoto, Masaki Muramatsu, Takeshi Kawamura, Ken Sakai, Seiichiro Shishido, Miyako Tazaki
BACKGROUND: Caregivers of patients with chronic kidney disease experience great burdens. Changes in these caregivers' quality of life (QOL) before and after their children underwent kidney transplantation (KTx) were evaluated in this prospective study. METHODS: The sequential QOL scores of 31 caregivers (median age 38.5 years) whose children (5.8 years) underwent KTx from 2012 to 2014 were studied. The same questionnaires were administered before and 1, 3, and 12 months after KTx...
July 6, 2018: Clinical and Experimental Nephrology
Magda Hamzawy, Sarah Ali Abdelhameed Gouda, Laila Rashed, Mary Attia Morcos, Heba Shoukry, Nivin Sharawy
BACKGROUND: The pathophysiology of ischemic acute kidney injury (AKI) is thought to include a complex interplay between tubular cell damage and regeneration. Several lines of evidences suggest a potential renoprotective effect of vitamin D. In this study, we investigated the effect of 22-oxacalcitriol (OCT), a synthetic vitamin D analogue, on renal fate in a rat model of ischemia reperfusion injury (IRI) induced acute kidney injury (AKI). METHODS: 22-oxacalcitriol (OCT) was administered via intraperitoneal (IP) injection before ischemia, and continued after IRI that was performed through bilateral clamping of the renal pedicles...
July 2, 2018: Clinical and Experimental Nephrology
Marina Asano, Takako Ishii, Akiyoshi Hirayama, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Shin-Ichi Akiyama, Shoichi Maruyama, Tomoyoshi Soga, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiko Ito
BACKGROUND: Ultrafiltration failure associated with peritoneal membrane dysfunction is one of the main complications for patients on long-term peritoneal dialysis (PD). The dialysate-to-plasma concentration ratio (D/P) of creatinine is widely used to assess peritoneal membrane function. However, other small-sized solutes have not been studied in detail as potential indicators of peritoneal permeability. METHODS: We studied the D/Ps of small, middle-sized and large molecules in peritoneal equilibration tests in 50 PD patients...
July 2, 2018: Clinical and Experimental Nephrology
Thomas J Wilkinson, Alice E M White, Daniel G D Nixon, Douglas W Gould, Emma L Watson, Alice C Smith
BACKGROUND: Chronic kidney disease (CKD) patients have reduced exercise capacity. Possible contributing factors may include impaired muscle O2 utilisation through reduced mitochondria number and/or function slowing the restoration of muscle ATP concentrations via oxidative phosphorylation. Using near-infrared spectroscopy (NIRS), we explored changes in skeletal muscle haemoglobin/myoglobin O2 saturation (SMO2 %) during exercise. METHODS: 24 CKD patients [58.3 (± 16...
June 30, 2018: Clinical and Experimental Nephrology
Priscilla Marys Costa Dos Santos, Deividi Amaral, Ana Lucia Tararthuch, Ricardo Fernandez
BACKGROUND: The calcium-sensing receptor (CaSR) is localized in the apical membrane of proximal tubules in close proximity to the transporters responsible for proton secretion. Therefore, the aim of the present study was to analyze the effects of CaSR stimulation on the biochemical activity of the vacuolar H+ -ATPase in a cellular model of proximal tubule cells, OKP cells. METHODS: Biochemical activity of H+ -ATPase was performed using cell homogenates, and the inorganic phosphate released was determined by a colorimetric method...
June 30, 2018: Clinical and Experimental Nephrology
Hideki Kato, Yoshitaka Miyakawa, Yoshihiko Hidaka, Norimitsu Inoue, Shuichi Ito, Shoji Kagami, Shinya Kaname, Masanori Matsumoto, Masashi Mizuno, Takahisa Matsuda, Akihiko Shimono, Shoichi Maruyama, Yoshihiro Fujimura, Masaomi Nangaku, Hirokazu Okada
BACKGROUND: Eculizumab has been available for the treatment of atypical hemolytic-uremic syndrome (aHUS) in Japan since 2013. To assess safety and effectiveness of eculizumab in adult aHUS patients in the real-life setting, we performed interim analysis of a post-marketing surveillance mandated by Japanese regulations. METHODS: This study enrolled any patient who was diagnosed with TMA excluding Shiga toxin-producing Escherichia coli-HUS or thrombotic thrombocytopenic purpura based on Japanese clinical guide published in 2013 as inclusion criteria and treated with eculizumab...
June 29, 2018: Clinical and Experimental Nephrology
Wenyan Zhou, Minfang Zhang, Zhaohui Ni
No abstract text is available yet for this article.
June 27, 2018: Clinical and Experimental Nephrology
Akihiro Kuma, Bungo Uchino, Yoko Ochiai, Masatoshi Kawashima, Kazuhiko Enta, Masahito Tamura, Yutaka Otsuji, Akihiko Kato
BACKGROUND: Obesity is a risk factor for the development of chronic kidney disease (CKD). However, it remains to be fully examined whether fatness is more useful in predicting incident CKD. We aimed this study to determine the association of body fat, body mass index and waist circumference (WC) with subsequent changes in estimated glomerular filtration rate (eGFR) and incident CKD in young- to middle-aged working men. METHODS: We analyzed data from annual health check-up in male workers aged from 20 to 60 years with basal eGFR of 60-90 mL/min/1...
June 27, 2018: Clinical and Experimental Nephrology
Kosaku Nitta, Satoshi Iimuro, Enyu Imai, Seiichi Matsuo, Hirofumi Makino, Tadao Akizawa, Tsuyoshi Watanabe, Yasuo Ohashi, Akira Hishida
BACKGROUND: Although left ventricular hypertrophy (LVH) has been established as a predictor of cardiovascular events in chronic kidney disease (CKD), the relationship between the prevalence of LVH and CKD stage during the pre-dialysis period has not been fully examined. METHODS: We measured left ventricular mass index (LVMI) in a cross-sectional cohort of participants in the Chronic Kidney Disease Japan Cohort (CKD-JAC) study to identify factors that are associated with increased LVMI in patients with stage 3-5 CKD...
June 27, 2018: Clinical and Experimental Nephrology
Tamayo Naka, Kentaro Kohagura, Masako Kochi, Yusuke Ohya
INTRODUCTION: Hyponatremia is common among elderly patients. This study aimed to examine the prognostic value of hyponatremia among elderly residents in a geriatric facility. METHODS: We retrospectively examined the association between serum sodium levels and mortality among 118 residents (82% female, mean age 85.5 years) in a single geriatric health service facility. We defined hyponatremia as Na < 135 mEq/L. On the basis of single measurements of serum sodium at periodic examinations, the patients were divided into hyponatremia and non-hyponatremia groups...
June 27, 2018: Clinical and Experimental Nephrology
Naoto Tominaga, Keisuke Kida, Takayuki Inomata, Naoki Sato, Tohru Izumi, Yoshihiro J Akashi, Yugo Shibagaki
BACKGROUND: Tolvaptan (TLV) is known to increase electrolyte-free water clearance. However, TLV actions on renal electrolytes including urine sodium (uNa) excretion and its consequences are less well understood. This subanalysis investigated the effect of add-on TLV compared to increased furosemide (FUR) on both electrolyte-free water and electrolyte clearance in patients with congestive heart failure (CHF) complicated by advanced chronic kidney disease (CKD). METHODS: The Kanagawa Aquaresis Investigators Trial of TLV on HF Patients with Renal Impairment (K-STAR) was a multicenter, open-labeled, randomized, and controlled prospective clinical study...
June 22, 2018: Clinical and Experimental Nephrology
Rieko Okada, Yoshinari Yasuda, Kazuyo Tsushita, Kenji Wakai, Nobuyuki Hamajima, Seiichi Matsuo
BACKGROUND: The purpose of this study is to determine the association of dipstick-determined trace proteinuria with metabolic syndrome (MetS) and its components in each age, gender, and eGFR category among a large general population. METHODS: A total of 270,190 people (102,223 men and 167,967 women) aged 40-74 years were included. Subjects were categorized as having negative, trace, and positive proteinuria by the dipstick method. RESULTS: The prevalence of MetS increased with increasing levels of proteinuria in any estimated glomerular filtration rate (eGFR) category (odds ratios for MetS relative to negative proteinuria: 1...
June 22, 2018: Clinical and Experimental Nephrology
Bart Dioos, Goedele Paternot, Rose-Marie Jenvert, Annick Duponchelle, Mark R Marshall, Migaku Nakajima, Edward Ramirez Ganoza, James A Sloand, Anders P Wieslander
BACKGROUND: The aim of this study was to investigate in vitro biocompatibility of Reguneal™, a new bicarbonate containing peritoneal dialysis fluid (PDF) for Japan, and compare it with other PDFs available in that country. METHODS: We assessed basal cytotoxicity using in vitro proliferation of cultured fibroblasts, L-929, determining the quantity of living cells by the uptake of Neutral Red. Levels of ten glucose degradation products (GDPs) were measured by a validated ultrahigh-performance liquid chromatography method in combination with an ultraviolet detector...
June 20, 2018: Clinical and Experimental Nephrology
Masashi Sakuma, Shigeru Toyoda, Takuo Arikawa, Yota Koyabu, Toru Kato, Taichi Adachi, Hideaki Suwa, Jun-Ichi Narita, Koetsu Anraku, Kimihiko Ishimura, Fumitake Yamauchi, Yasunori Sato, Teruo Inoue
BACKGROUND: Hyperuricemia has a close relationship with cardiovascular diseases including heart failure. However, it is controversial whether xanthine oxidase inhibition has benefits for patients with chronic heart failure. We designed the Effect of Xanthine Oxidase Inhibitor in Chronic Heart Failure Patients Complicated with Hyperuricemia study (Excited-UA study) to compare the beneficial effects between a novel xanthine oxidoreductase inhibitor, topiroxostat, and a conventional agent, allopurinol, in patients with chronic heart failure and hyperuricemia...
June 18, 2018: Clinical and Experimental Nephrology
Cibele Puato Almeida, André Luís Balbi, Daniela Ponce
BACKGROUND: Peritoneal dialysis (PD) and hemodialysis (HD) are options for the treatment of acute kidney injury (AKI) patients. The aim of this study was to compare the effects of PD and daily HD on respiratory mechanics of AKI patients undergoing invasive mechanical ventilation (IMV). METHODS: A prospective cohort study evaluated 154 patients, 37 on continuous PD and 94 on HD. Respiratory mechanics parameters such as pulmonary static compliance (Psc) and resistance of the respiratory system (Rsr) and oxygenation index (OI) were assessed for 3 days...
June 11, 2018: Clinical and Experimental Nephrology
Harin Rhee, Gum Sook Jang, Yeo Jin An, Miyeun Han, Inseong Park, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Sang Heon Song
INTRODUCTION: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is the most severe form of AKI associated with poor short- and long-term patient outcomes. The aim of this study was to evaluate the variables associated with long-term patient survival in our clinic. METHODS: This was a single-center retrospective study with AKI survivors who received CRRT from March 2011 to February 2015. During the study period, all consecutive AKI survivors who underwent CRRT were included...
June 11, 2018: Clinical and Experimental Nephrology
Lyudmila Milovanova, Victor Fomin, Sergey Moiseev, Marina Taranova, Yury Milovanov, Lidia Lysenko Kozlovskaya, Vasiliy Kozlov, Elena Kozevnikova, Svetlana Milovanova, Marina Lebedeva, Vladimir Reshetnikov
BACKGROUND: A low protein diet (LPD) with essential amino acid ketoanalogue supplementation (KA) may contribute in improving of chronic kidney disease (CKD), while the exact mechanisms of KA's effect are not established yet. We have conducted a prospective, randomized, controlled comparative study of LPD + KA and LPD alone in relation to serum Klotho, FGF-23 levels in CKD patients. METHODS: 79 non-diabetic CKD 3b-4 stage patients, compliant with LPD diet (0...
June 11, 2018: Clinical and Experimental Nephrology
Emil den Bakker, Berend Koene, Joanna A E van Wijk, Isabelle Hubeek, Reinoud Gemke, Arend Bökenkamp
BACKGROUND: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. METHODS: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103...
June 9, 2018: Clinical and Experimental Nephrology
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