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Korean Journal of Physiology & Pharmacology

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https://www.readbyqxmd.com/read/28461778/expression-profile-of-mitochondrial-voltage-dependent-anion-channel-1-vdac1-influenced-genes-is-associated-with-pulmonary-hypertension
#1
Tong Zhou, Haiyang Tang, Ying Han, Dustin Fraidenburg, Young-Won Kim, Donghee Lee, Jeongyoon Choi, Hyoweon Bang, Jae-Hong Ko
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461777/js-iii-49-a-hydroquinone-derivative-exerts-anti-inflammatory-activity-by-targeting-akt-and-p38
#2
Young-Su Yi, Mi-Yeon Kim, Jae Youl Cho
Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophage-mediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE2) and down-regulated the mRNA expression of the inflammatory enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as the expression of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-1b without cytotoxicity in LPS-stimulated RAW264...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461776/therapeutic-effects-of-orally-administered-cjlp55-for-atopic-dermatitis-via-the-regulation-of-immune-response
#3
Kyeong Eun Hyung, Soo Jeong Kim, Ye Won Jang, Da Kyoung Lee, Kee Hyeob Hyun, Byoung Seok Moon, Bongjoon Kim, Heeyoon Ahn, So-Young Park, Uy Dong Sohn, Eon Sub Park, Kwang Woo Hwang
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461775/dust-particles-induced-intracellular-ca-2-signaling-and-reactive-oxygen-species-in-lung-fibroblast-cell-line-mrc5
#4
Dong Un Lee, Min Jeong Ji, Jung Yun Kang, Sun Young Kyung, Jeong Hee Hong
Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it has not been established Ca(2+) signaling mechanisms involved in acute PM-derived signaling in pulmonary fibroblasts. In the present study, we explored dust particles PM modulated intracellular Ca(2+) signaling and sought to provide a therapeutic strategy by antagonizing PM-induced intracellular Ca(2+) signaling in human lung fibroblasts MRC5 cells...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461774/endogenous-catalase-delays-high-fat-diet-induced-liver-injury-in-mice
#5
Lingjuan Piao, Jiyeon Choi, Guideock Kwon, Hunjoo Ha
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of NAFLD. Peroxisomes play an important role in fatty acid oxidation and ROS homeostasis, and catalase is an antioxidant exclusively expressed in peroxisome. The present study examined the role of endogenous catalase in early stage of NAFLD. 8-week-old male catalase knock-out (CKO) and age-matched C57BL/6J wild type (WT) mice were fed either a normal diet (ND: 18% of total calories from fat) or a high fat diet (HFD: 60% of total calories from fat) for 2 weeks...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461773/activation-of-transient-receptor-potential-vanilloid-3-by-the-methanolic-extract-of-schisandra-chinensis-fruit-and-its-chemical-constituent-%C3%AE-schisandrin
#6
Yuran Nam, Hyun Jong Kim, Young-Mi Kim, Young-Won Chin, Yung Kyu Kim, Hyo Sang Bae, Joo Hyun Nam, Woo Kyung Kim
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes such as thermal sensation, skin barrier formation, and wound healing. TRPV3 was initially proposed as a warm temperature sensor. It is activated by synthetic small-molecule chemicals and plant-derived natural compounds such as camphor and eugenol. Schisandra chinensis (Turcz.) Baill (SC) has diverse pharmacological properties including antiallergic, anti-inflammatory, and wound healing activities...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461772/pi3k-and-erk-signaling-pathways-are-involved-in-differentiation-of-monocytic-cells-induced-by-27-hydroxycholesterol
#7
Yonghae Son, Bo-Young Kim, Young Chul Park, Seong-Kug Eo, Hyok-Rae Cho, Koanhoi Kim
27-Hydroxycholesterol induces differentiation of monocytic cells into mature dendritic cells, mDCs. In the current study we sought to determine roles of the PI3K and the ERK pathways in the 27OHChol-induced differentiation. Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK. Surface expression of MHC class I and II molecules elevated by 27OHChol was decreased to basal levels in the presence of the inhibitors...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461771/peroxisome-proliferator-activated-receptor-%C3%AE-is-essential-for-secretion-of-anp-induced-by-prostaglandin-d2-in-the-beating-rat-atrium
#8
Ying Zhang, Xiang Li, Li-Ping Liu, Lan Hong, Xia Liu, Bo Zhang, Cheng-Zhe Wu, Xun Cui
Prostaglandin D2 (PGD2) may act against myocardial ischemia-reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of PGD2 in regulation of ANP secretion of the atrium was reported, the mechanisms involved are not clearly identified. The aim of the present study was to investigate whether PGD2 can regulate ANP secretion in the isolated perfused beating rat atrium, and its underlying mechanisms. PGD2 (0.1 to 10 µM) significantly increased atrial ANP secretion concomitantly with positive inotropy in a dose-dependent manner...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461770/pimecrolimus-increases-the-melanogenesis-and-migration-of-melanocytes-in-vitro
#9
Ping Xu, Jie Chen, Cheng Tan, Ren-Sheng Lai, Zhong-Sheng Min
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28461769/identification-of-ampk-activator-from-twelve-pure-compounds-isolated-from-aralia-taibaiensis-implication-in-antihyperglycemic-and-hypolipidemic-activities
#10
Yuwen Li, Jongsun Park, Yin Wu, Jia Cui, Na Jia, Miaomiao Xi, Aidong Wen
The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic and hypolipidemic activities in experimental type 2 diabetic rats. However, the active compounds have not yet been fully investigated. In the present study, we examined effects of twelve triterpenoid saponins on AMP-activated protein kinase (AMPK) activation, and found that compound 28-O-β-D-glucopyranosyl ester (AT12) significantly increased phosphorylation of AMPK and Acetyl-CoA carboxylase (ACC)...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280423/retraction-notice-to-resveratrol-attenuates-lipopolysaccharide-induced-dysfunction-of-blood-brain-barrier-in-endothelial-cells-via-ampk-activation
#11
Min Hu, Bo Liu
[This retracts the article on p. 325 in vol. 20, PMID: 27382348.].
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280421/the-oncogenic-effects-of-p53-inducible-gene-3-pig3-in-colon-cancer-cells
#12
Seon-Joo Park, Hong Beum Kim, Jeeho Kim, Sanggon Park, Seok Won Kim, Jung-Hee Lee
The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colonderived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280420/chronic-ca-2-influx-through-voltage-dependent-ca-2-channels-enhance-delayed-rectifier-k-currents-via-activating-src-family-tyrosine-kinase-in-rat-hippocampal-neurons
#13
Yoon-Sil Yang, Sang-Chan Jeon, Dong-Kwan Kim, Su-Yong Eun, Sung-Cherl Jung
Excessive influx and the subsequent rapid cytosolic elevation of Ca(2+) in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regulate cytosolic Ca(2+) level in normal as well as pathological conditions. Delayed rectifier K(+) channels (IDR channels) play a role to suppress membrane excitability by inducing K(+) outflow in various conditions, indicating their potential role in preventing pathogenic conditions and cell damage under Ca(2+)-mediated excitotoxic conditions...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280419/inhibition-of-k-outward-currents-by-linopirdine-in-the-cochlear-outer-hair-cells-of-circling-mice-within-the-first-postnatal-week
#14
Shin Wook Kang, Ji Woong Ahn, Seung Cheol Ahn
Inhibition of K(+) outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) and ICR mice of the same age (postnatal day (P) 0 -P6) were used as controls. Voltage steps from -100 mV to 40 mV elicited small inward currents (-100 mV~-70 mV) and slow rising K(+) outward currents (-60 mV ~40 mV) which activated near -50 mV in all OHCs tested...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280418/intracellular-calcium-dependent-regulation-of-the-sperm-specific-calcium-activated-potassium-channel-hslo3-by-the-bkca-activator-ldd175
#15
Tharaka Darshana Wijerathne, Jihyun Kim, Dongki Yang, Kyu Pil Lee
Plasma membrane hyperpolarization associated with activation of Ca(2+)-activated K(+) channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2-subunit, LRRC52 (leucine-rich-repeat-containing 52), is known to mediate the pH-sensitive, sperm-specific K(+) current KSper in mice, the molecular identity of this channel in human sperm remains controversial. In this study, we tested the classical BKCa activators, NS1619 and LDD175, on human Slo3, heterologously expressed in HEK293 cells together with its functional interacting γ2 subunit, hLRRC52...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280417/hydrogen-peroxide-attenuates-refilling-of-intracellular-calcium-store-in-mouse-pancreatic-acinar-cells
#16
Mi Na Yoon, Dong Kwan Kim, Se Hoon Kim, Hyung Seo Park
Intracellular calcium (Ca(2+)) oscillation is an initial event in digestive enzyme secretion of pancreatic acinar cells. Reactive oxygen species are known to be associated with a variety of oxidative stress-induced cellular disorders including pancreatitis. In this study, we investigated the effect of hydrogen peroxide (H2O2) on intracellular Ca(2+) accumulation in mouse pancreatic acinar cells. Perfusion of H2O2 at 300 µM resulted in additional elevation of intracellular Ca(2+) levels and termination of oscillatory Ca(2+) signals induced by carbamylcholine (CCh) in the presence of normal extracellular Ca(2+)...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280416/nortriptyline-a-tricyclic-antidepressant-inhibits-voltage-dependent-k-channels-in-coronary-arterial-smooth-muscle-cells
#17
Sung Eun Shin, Hongliang Li, Han Sol Kim, Hye Won Kim, Mi Seon Seo, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Amy L Firth, Il-Whan Choi, Young Min Bae, Won Sun Park
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K(+) (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280415/effects-of-acidic-ph-on-voltage-gated-ion-channels-in-rat-trigeminal-mesencephalic-nucleus-neurons
#18
Jin-Eon Han, Jin-Hwa Cho, In-Sun Choi, Do-Yeon Kim, Il-Sung Jang
The effects of acidic pH on several voltage-dependent ion channels, such as voltage-dependent K(+) and Ca(2+) channels, and hyperpolarization-gated and cyclic nucleotide-activated cation (HCN) channels, were examined using a whole-cell patch clamp technique on mechanically isolated rat mesencephalic trigeminal nucleus neurons. The application of a pH 6.5 solution had no effect on the peak amplitude of voltage-dependent K(+) currents. A pH 6.0 solution slightly, but significantly inhibited the peak amplitude of voltage-dependent K(+) currents...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280414/quercetin-induces-apoptosis-and-cell-cycle-arrest-in-triple-negative-breast-cancer-cells-through-modulation-of-foxo3a-activity
#19
Lich Thi Nguyen, Yeon-Hee Lee, Ashish Ranjan Sharma, Jong-Bong Park, Supriya Jagga, Garima Sharma, Sang-Soo Lee, Ju-Suk Nam
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression...
March 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28280413/effect-of-oleanolic-acid-on-the-activity-secretion-and-gene-expression-of-matrix-metalloproteinase-3-in-articular-chondrocytes-in-vitro-and-the-production-of-matrix-metalloproteinase-3-in-vivo
#20
Dong-Geun Kang, Hyun Jae Lee, Kun Tae Kim, Sun-Chul Hwang, Choong Jae Lee, Jin Sung Park
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen...
March 2017: Korean Journal of Physiology & Pharmacology
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