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Korean Journal of Physiology & Pharmacology

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https://www.readbyqxmd.com/read/29302217/caffeic-acid-phenethyl-ester-protects-against-photothrombotic-cortical-ischemic-injury-in-mice
#1
Sun Ae Hwang, Chi Dae Kim, Won Suk Lee
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302216/functional-identification-of-protein-phosphatase-1-binding-consensus-residues-in-nbce1-b
#2
Kyu Pil Lee, Hyun Jin Kim, Dongki Yang
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B. Consequently, we focused on identifying the function of the PP1-binding consensus residue, 922FMDRLK927, in NBCe1-B. Using site-directed mutagenesis and co-immunoprecipitation assays, we revealed that in cases where the residues were substituted (F922A, R925A, and K927A) or deleted (deletion of amino acids 922-927), NBCe1-B mutants inhibited PP1 binding to NBCe1-B...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302215/inhibitory-effects-of-2-6-di-tert-butyl-4-hydroxymethylphenol-on-asthmatic-responses-to-ovalbumin-challenge-in-conscious-guinea-pigs
#3
Seul-Yong Jeong, Ji-Yun Lee
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302214/antidepressant-drug-paroxetine-blocks-the-open-pore-of-kv3-1-potassium-channel
#4
Hyang Mi Lee, Ok Hee Chai, Sang June Hahn, Bok Hee Choi
In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures associated with antidepressants. To determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (SSRI), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on Kv3.1 potassium channels, which contribute to highfrequency firing of interneurons, using the whole-cell patch-clamp technique...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302213/cilostazol-attenuates-kainic-acid-induced-hippocampal-cell-death
#5
Young-Seop Park, Zhen Jin, Eun Ae Jeong, Chin-Ok Yi, Jong Youl Lee, In Sung Park, Gu Seob Roh
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302212/ethyl-linoleate-inhibits-%C3%AE-msh-induced-melanogenesis-through-akt-gsk3%C3%AE-%C3%AE-catenin-signal-pathway
#6
Gyeong-A Ko, Somi Kim Cho
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in α-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302211/epigenetic-modification-of-%C3%AE-n-acetylgalactosaminidase-enhances-cisplatin-resistance-in-ovarian-cancer
#7
Ye-Na Ha, Hye Youn Sung, San-Duk Yang, Yun Ju Chae, Woong Ju, Jung-Hyuck Ahn
Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier to successful therapy. The precise mechanisms underlying the development of cisplatin resistance are not fully understood, but alteration of DNA methylation associated with aberrant gene silencing may play a role. To identify epigenetically regulated genes directly associated with ovarian cancer cisplatin resistance, we compared the expression and methylation profiles of cisplatin-sensitive and -resistant human ovarian cancer cell lines...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302210/alleviation-of-ascorbic-acid-induced-gastric-high-acidity-by-calcium-ascorbate-in-vitro-and-in-vivo
#8
Joon-Kyung Lee, Sang-Hyuk Jung, Sang-Eun Lee, Joo-Hui Han, Eunji Jo, Hyun-Soo Park, Kyung-Sun Heo, Deasun Kim, Jeong-Sook Park, Chang-Seon Myung
Ascorbic acid is one of the most well-known nutritional supplement and antioxidant found in fruits and vegetables. Calcium ascorbate has been developed to mitigate the gastric irritation caused by the acidity of ascorbic acid. The aim of this study was to compare calcium ascorbate and ascorbic acid, focusing on their antioxidant activity and effects on gastric juice pH, total acid output, and pepsin secretion in an in vivo rat model, as well as pharmacokinetic parameters. Calcium ascorbate and ascorbic acid had similar antioxidant activity...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302209/histone-deacetylase-inhibition-attenuates-hepatic-steatosis-in-rats-with-experimental-cushing-s-syndrome
#9
Mina Kim, Hae-Ahm Lee, Hyun-Min Cho, Seol-Hee Kang, Eunjo Lee, In Kyeom Kim
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic hormone (ACTH; 40 ng/kg/day) to Sprague-Dawley rats by subcutaneous infusion with osmotic mini-pumps. We administered the HDACi, sodium valproate (VPA; 0...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302208/morroniside-on-anti-inflammation-activities-in-rats-following-acute-myocardial-infarction
#10
Bangxing Yu, Guoxing Zhang, Yi An, Wen Wang
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29302207/role-of-inflammasomes-in-inflammatory-autoimmune-rheumatic-diseases
#11
REVIEW
Young-Su Yi
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)-1β and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and Sjögren's syndrome (SS)...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200913/developmental-changes-in-gabaa-tonic-inhibition-are-compromised-by-multiple-mechanisms-in-preadolescent-dentate-gyrus-granule-cells
#12
Sudip Pandit, Gyu Seung Lee, Jin Bong Park
The sustained tonic currents (Itonic) generated by γ-aminobutyric acid A receptors (GABAARs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating Itonic in the hippocampus are known, their combined role in Itonic regulation is not well understood in different age groups. In this study, we demonstrated that a developmental increase in GABA transporter (GAT) expression, combined with gradual decrease in GABAAR α5 subunit, resulted in various Itonic in the dentate gyrus granule cells (DGGCs) of preadolescent rats...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200912/biphasic-augmentation-of-alpha-adrenergic-contraction-by-plumbagin-in-rat-systemic-arteries
#13
Hae Jin Kim, Hae Young Yoo, Yin Hua Zhang, Woo Kyung Kim, Sung Joon Kim
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in pulmonary and coronary arteries where NADPH oxidase (NOX) inhibition was suggested as a mechanism. Here we investigate the effects of plumbagin on the contractility of skeletal artery (deep femoral artery, DFA), mesenteric artery (MA) and renal artery (RA) in rats...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200911/dual-control-of-the-vestibulosympathetic-reflex-following-hypotension-in-rats
#14
Sang Eon Park, Yuan-Zhe Jin, Byung Rim Park
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200910/comparative-effects-of-angiotensin-ii-and-angiotensin-4-8-on-blood-pressure-and-anp-secretion-in-rats
#15
Hoang Thi Ai Phuong, Lamei Yu, Byung Mun Park, Suhn Hee Kim
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different biological effects but it remains unknown whether Ang-(4-8) is an active peptide. The present study was to investigate the effects of Ang-(4-8) on hemodynamics and atrial natriuretic peptide (ANP) secretion using isolated beating rat atria. Atrial stretch caused increases in atrial contractility by 60% and in ANP secretion by 70%...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200909/the-efficacy-of-combination-treatment-of-gabapentin-and-electro-acupuncture-on-paclitaxel-induced-neuropathic-pain
#16
Min Joon Kim, Ji Hwan Lee, Jo Ung Jang, Fu Shi Quan, Sun Kwang Kim, Woojin Kim
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced cold and mechanical allodynia, which were assessed by the acetone drop test and von Frey filament assay, respectively...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200908/ursolic-acid-supplementation-decreases-markers-of-skeletal-muscle-damage-during-resistance-training-in-resistance-trained-men-a-pilot-study
#17
Hyun Seok Bang, Dae Yun Seo, Young Min Chung, Do Hyung Kim, Sam-Jun Lee, Sung Ryul Lee, Hyo-Bum Kwak, Tae Nyun Kim, Min Kim, Kyoung-Mo Oh, Young Jin Son, Sanghyun Kim, Jin Han
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200907/chronic-cerebral-hypoperfusion-and-plasticity-of-the-posterior-cerebral-artery-following-permanent-bilateral-common-carotid-artery-occlusion
#18
Kyung-Ok Cho, Seul-Ki Kim, Seong Yun Kim
Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of Wistar and Sprague-Dawley (SD) rats subjected to permanent bilateral common carotid artery occlusion (BCCAo). Eight-week old male Wistar and SD rats underwent BCCAo, followed by a reference memory test using a five-radial arm maze with tactile cues. Continuous monitoring of cerebral blood flow (CBF) was performed with a laser Doppler perfusion imaging (LDPI) system...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200906/effects-of-intermittent-ladder-climbing-exercise-training-on-mitochondrial-biogenesis-and-endoplasmic-reticulum-stress-of-the-cardiac-muscle-in-obese-middle-aged-rats
#19
Kijin Kim, Nayoung Ahn, Suryun Jung, Solee Park
The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200905/mptp-induced-vulnerability-of-dopamine-neurons-in-a53t-%C3%AE-synuclein-overexpressed-mice-with-the-potential-involvement-of-dj-1-downregulation
#20
Seongmi Lee, Seung Tack Oh, Ha Jin Jeong, Sok Cheon Pak, Hi-Joon Park, Jongpil Kim, Hyun-Seok Cho, Songhee Jeon
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygous (hemi) or homozygous (homo) A53T α-synuclein (α-syn Tg) and their wildtype (WT) littermates by treatment with sub-toxic (10 mg/kg, i.p., daily for 5 days) or toxic (30 mg/kg, i.p., daily for 5 days) dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
November 2017: Korean Journal of Physiology & Pharmacology
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