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Korean Journal of Physiology & Pharmacology

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https://www.readbyqxmd.com/read/29722355/corrigendum-to-effects-of-salmon-dna-fraction-in-vitro-and-in-a-monosodium-iodoacetate-induced-osteoarthritis-rat-model
#1
Ho Jong Ra, Mi Young Oh, Hee Ju Kim, Seung Yong Lee, Dae Woon Eom, Suk Kyu Lee, Su-Nam Kim, Kyu Sung Chung, Hyuk Jai Jang
[This corrects the article on p. 163 in vol. 22, PMID: 29520169.].
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719457/anti-apoptotic-effects-of-autophagy-via-ros-regulation-in-microtubule-targeted-and-pdgf-stimulated-vascular-smooth-muscle-cells
#2
Hyun-Soo Park, Joo-Hui Han, Sang-Hyuk Jung, Do-Hyung Lee, Kyung-Sun Heo, Chang-Seon Myung
Autophagy has been studied as a therapeutic strategy for cardiovascular diseases. However, insufficient studies have been reported concerning the influence of vascular smooth muscle cells (VSMCs) through autophagy regulation. The aim of the present study was to determine the effects of VSMCs on the regulation of autophagy under in vitro conditions similar to vascular status of the equipped microtubule target agent-eluting stent and increased release of platelet-derived growth factor-BB (PDGF-BB). Cell viability and proliferation were measured using MTT and cell counting assays...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719456/increased-store-operated-ca-2-entry-mediated-by-gnb5-and-stim1
#3
Namju Kang, Jung Yun Kang, Soonhong Park, Dong Min Shin
Recent human genetic studies have shown that Gβ5 is related to various clinical symptoms, such as sinus bradycardia, cognitive disability, and attention deficit hyperactivity disorder. Although the calcium signaling cascade is closely associated with a heterotrimeric G-protein, the function of Gβ5 in calcium signaling and its relevance to clinical symptoms remain unknown. In this study, we investigated the in vitro changes of store-operated calcium entry (SOCE) with exogenous expression of Gβ5. The cells expressing Gβ5 had enhanced SOCE after depletion of calcium ion inside the endoplasmic reticulum...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719455/preemptive-application-of-qx-314-attenuates-trigeminal-neuropathic-mechanical-allodynia-in-rats
#4
Jeong-Ho Yoon, Jo-Young Son, Min-Ji Kim, Song-Hee Kang, Jin-Sook Ju, Yong-Chul Bae, Dong-Kuk Ahn
The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male Sprague-Dawley rats using chronic constriction injury of the infraorbital nerve (CCI-ION) and perineural application of 2% QX-314 to the infraorbital nerve. CCI-ION produced severe mechanical allodynia, which was maintained until postoperative day (POD) 30. An immediate single application of 2% QX-314 to the infraorbital nerve following CCI-ION significantly reduced neuropathic mechanical allodynia...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719454/physiologically-based-pharmacokinetic-predictions-of-intestinal-bcrp-mediated-drug-interactions-of-rosuvastatin-in-koreans
#5
Soo Hyeon Bae, Wan-Su Park, Seunghoon Han, Gab-Jin Park, Jongtae Lee, Taegon Hong, Sangil Jeon, Dong-Seok Yim
It was recently reported that the Cmax and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions between rosuvastatin and two perpetrators, telmisartan and cyclosporine. Published (cyclosporine) or newly developed (telmisartan) PBPK models were used to this end. The rosuvastatin model in Simcyp (version 15)'s drug library was modified to reflect racial differences in rosuvastatin exposure...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719453/nobiletin-attenuates-neurotoxic-mitochondrial-calcium-overload-through-k-influx-and-%C3%AE-%C3%AE-m-across-mitochondrial-inner-membrane
#6
Ji Hyung Lee, Khulan Amarsanaa, Jinji Wu, Sang-Chan Jeon, Yanji Cui, Sung-Cherl Jung, Deok-Bae Park, Se-Jae Kim, Sang-Heon Han, Hyun-Wook Kim, Im Joo Rhyu, Su-Yong Eun
Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium influx into mitochondria is mitochondria membrane potential (ΔΨm ). Therefore, pharmacological manipulation of ΔΨm can be a promising strategy to prevent neuronal cell death against brain insults. Based on these issues, we investigated here whether nobiletin, a Citrus polymethoxylated flavone, prevents neurotoxic neuronal calcium overload and cell death via regulating basal ΔΨm against neuronal insult in primary cortical neurons and pure brain mitochondria isolated from rat cortices...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719452/atorvastatin-pretreatment-attenuates-kainic-acid-induced-hippocampal-neuronal-death-via-regulation-of-lipocalin-2-associated-neuroinflammation
#7
Zhen Jin, Yohan Jung, Chin-Ok Yi, Jong Youl Lee, Eun Ae Jeong, Jung Eun Lee, Ki-Jong Park, Oh-Young Kwon, Byeong Hoon Lim, Nack-Cheon Choi, Gu Seob Roh
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719451/establishment-and-evaluation-of-the-vx2-orthotopic-lung-cancer-rabbit-model-a-ultra-minimal-invasive-percutaneous-puncture-inoculation-method
#8
Lijuan Wang, Keke Che, Zhonghong Liu, Xianlong Huang, Shifeng Xiang, Fei Zhu, Yu Yu
The purpose of the present work is to establish an ultra-minimal invasive percutaneous puncture inoculation method for a VX2 orthotopic lung cancer rabbit model with fewer technical difficulties, lower mortality of rabbits, a higher success rate and a shorter operation time, to evaluate the growth, metastasis and apoptosis of tumor by CT scans, necropsy, histological examination, flow cytometry and immunohistochemistry. The average inoculation time was 10-15 min per rabbit. The tumor-bearing rate was 100%. More than 90% of the tumor-bearing rabbits showed local solitary tumor with 2-10 mm diameters after two weeks post-inoculation, and the rate of chest seeding was only 8...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719450/exposure-to-835-mhz-rf-emf-decreases-the-expression-of-calcium-channels-inhibits-apoptosis-but-induces-autophagy-in-the-mouse-hippocampus
#9
Ju Hwan Kim, Uy Dong Sohn, Hyung-Gun Kim, Hak Rim Kim
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central nervous system (CNS). In this study, we explored the relationship between calcium channels and apoptosis or autophagy in the hippocampus of C57BL/6 mice after RF-EMF exposure with a specific absorption rate (SAR) of 4.0 W/kg for 4 weeks. Firstly, the expression level of voltage-gated calcium channels (VGCCs), a key regulator of the entry of calcium ions into the cell, was confirmed by immunoblots...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719449/up-regulation-of-nhe8-by-somatostatin-ameliorates-the-diarrhea-symptom-in-infectious-colitis-mice-model
#10
Xuelian Lei, Lin Cai, Xiao Li, Hua Xu, Chong Geng, Chunhui Wang
Na+ /H+ exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Na+ /H+ exchanger isoform 8 (NHE8) impairs intestinal mucosa. Whether NHE8 participates in the pathology of infectious colitis is still unknown. Our previous study demonstrated that somatostatin (SST) could stimulate the expression of intestinal NHE8 so as to facilitate Na+ absorption under normal condition. This study further explored whether NHE8 participates in the pathological processes of infectious colitis and the effects of SST on intestinal NHE8 expression in the setting of infectious colitis...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719448/effects-of-cinnamic-acid-on-memory-deficits-and-brain-oxidative-stress-in-streptozotocin-induced-diabetic-mice
#11
Ali Asghar Hemmati, Soheila Alboghobeish, Akram Ahangarpour
The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48 male Naval Medical Research Institute (NMRI) mice (30-35 g) were chosen and were randomly divided into six groups: control, cinnamic acid (20 mg/kg day, i.p. ), diabetic, and cinnamic acid-treated diabetic (10, 20 and 40 mg/kg day, i.p. ). Memory was impaired by administering an intraperitoneal STZ injection of 50 mg/kg...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719447/echinacoside-an-active-constituent-of-herba-cistanche-suppresses-epileptiform-activity-in-hippocampal-ca3-pyramidal-neurons
#12
Cheng-Wei Lu, Shu-Kuei Huang, Tzu-Yu Lin, Su-Jane Wang
Echinacoside, an active compound in the herb Herba Cistanche , has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission changes induced by 4-aminopyridine (4-AP), by using the in vitro rat hippocampal slice technique and whole-cell patch clamp recordings from CA3 pyramidal neurons. Perfusion with echinacoside significantly suppressed the 4-AP-induced epileptiform activity in a concentration-dependent manner. Echinacoside reduced 4-AP-induced increase in frequency of spontaneous excitatory postsynaptic currents (sEPSCs) but it did not affect the amplitude of sEPSCs or glutamate-activated currents, implicating a presynaptic mechanism of action...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719446/ursolic-acid-in-health-and-disease
#13
REVIEW
Dae Yun Seo, Sung Ryul Lee, Jun-Won Heo, Mi-Hyun No, Byoung Doo Rhee, Kyung Soo Ko, Hyo-Bum Kwak, Jin Han
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29719445/mechanisms-involved-in-adenosine-pharmacological-preconditioning-induced-cardioprotection
#14
REVIEW
Lovedeep Singh, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh Jaggi
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520174/hydrogen-peroxide-inhibits-ca-2-efflux-through-plasma-membrane-ca-2-atpase-in-mouse-parotid-acinar-cells
#15
Min Jae Kim, Kyung Jin Choi, Mi Na Yoon, Sang Hwan Oh, Dong Kwan Kim, Se Hoon Kim, Hyung Seo Park
Intracellular Ca2+ mobilization is closely linked with the initiation of salivary secretion in parotid acinar cells. Reactive oxygen species (ROS) are known to be related to a variety of oxidative stress-induced cellular disorders and believed to be involved in salivary impairments. In this study, we investigated the underlying mechanism of hydrogen peroxide (H2 O2 ) on cytosolic Ca2+ accumulation in mouse parotid acinar cells. Intracellular Ca2+ levels were slowly elevated when 1 mM H2 O2 was perfused in the presence of normal extracellular Ca2+ ...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520173/hypoxia-dependent-mitochondrial-fission-regulates-endothelial-progenitor-cell-migration-invasion-and-tube-formation
#16
Da Yeon Kim, Seok Yun Jung, Yeon Ju Kim, Songhwa Kang, Ji Hye Park, Seung Taek Ji, Woong Bi Jang, Shreekrishna Lamichane, Babita Dahal Lamichane, Young Chan Chae, Dongjun Lee, Joo Seop Chung, Sang-Mo Kwon
Tumor undergo uncontrolled, excessive proliferation leads to hypoxic microenvironment. To fulfill their demand for nutrient, and oxygen, tumor angiogenesis is required. Endothelial progenitor cells (EPCs) have been known to the main source of angiogenesis because of their potential to differentiation into endothelial cells. Therefore, understanding the mechanism of EPC-mediated angiogenesis in hypoxia is critical for development of cancer therapy. Recently, mitochondrial dynamics has emerged as a critical mechanism for cellular function and differentiation under hypoxic conditions...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520172/fluvastatin-inhibits-advanced-glycation-end-products-induced-proliferation-migration-and-extracellular-matrix-accumulation-in-vascular-smooth-muscle-cells-by-targeting-connective-tissue-growth-factor
#17
Ae-Rang Hwang, Ju-Ock Nam, Young Jin Kang
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520171/berberine-alleviates-symptoms-of-anxiety-by-enhancing-dopamine-expression-in-rats-with-post-traumatic-stress-disorder
#18
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520170/oxytocin-produces-thermal-analgesia-via-vasopressin-1a-receptor-by-modulating-trpv1-and-potassium-conductance-in-the-dorsal-root-ganglion-neurons
#19
Rafael Taeho Han, Han-Byul Kim, Young-Beom Kim, Kyungmin Choi, Gi Yeon Park, Pa Reum Lee, JaeHee Lee, Hye Young Kim, Chul-Kyu Park, Youngnam Kang, Seog Bae Oh, Heung Sik Na
Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In the present study, we aimed to identify which receptor could mediate the analgesic effect of intraperitoneal injection of oxytocin and its cellular mechanisms in thermal pain behavior. We found that oxytocin-induced analgesia could be reversed by d(CH2 )5 [Tyr(Me)2 ,Dab5 ] AVP, a vasopressin-1a (V1a) receptor antagonist, but not by desGly-NH2 -d(CH2 )5 [DTyr2 , Thr4 ]OVT, an oxytocin receptor antagonist...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29520169/effects-of-salmon-dna-fraction-in-vitro-and-in-a-monosodium-iodoacetate-induced-osteoarthritis-rat-model
#20
Ho Jong Ra, Mi Young Oh, Hee Ju Kim, Seung Yong Lee, Dae Woon Eom, Suk Kyu Lee, Su-Nam Kim, Kyu Sung Chung, Hyuk Jai Jang
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as the protective effect of PRF001 intake against arthritis in a rat model. In vitro , cell survival and inflammatory markers after H2 O2 treatment to induce cell damage were investigated in CHON-001 cells treated with different concentrations of PRF001. In vivo , osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of rats...
March 2018: Korean Journal of Physiology & Pharmacology
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