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Nitric Oxide: Biology and Chemistry

Jeffrey A Kline, Michael A Puskarich, Alan E Jones, Ronald A Mastouri, Cassandra L Hall, Anthony Perkins, Emily Gundert, Tim Lahm
OBJECTIVE: To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE. METHODS: This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Subjects received either oxygen plus 50 parts per million nitrogen (placebo) or oxygen plus 50 ppm NO for 24 h...
January 8, 2019: Nitric Oxide: Biology and Chemistry
Gabriela Freitas P de Souza, Jaqueline Priscilla Denadai, Guilherme F Picheth, Marcelo Ganzarolli de Oliveira
Primary S-nitrosothiols (RSNOs) have received significant attention for their ability to modulate NO signaling in many physiological and pathophysiological processes. Such actions and their potential pharmaceutical uses demand a better knowledge of their stability in aqueous solutions. Herein, we investigated the effects of concentration, temperature, pH, room light and metal ions on the long-term kinetic behavior of two representatives primary RSNOs, S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC)...
January 7, 2019: Nitric Oxide: Biology and Chemistry
Tadamitsu Tsuneyoshi, Kayo Kunimura, Naoaki Morihara
Garlic has been demonstrated to exert protective effects against oxidative damage using numerous experimental models. The antioxidant effects of garlic are associated with the activation of Nrf2-dependent gene expression. S-1-Propenylcysteine (S1PC) and S-allylcysteine (SAC) are two predominant sulfur amino acids present in aged garlic extract; however, the exact roles of these amino acids within the Keap1/Nrf2 system remain unknown. We hypothesized that sulfur-containing amino acids derived from garlic could activate Nrf2 in the presence of nitric oxide (NO)...
January 7, 2019: Nitric Oxide: Biology and Chemistry
Alec Lutzke, Alyssa C Melvin, Megan J Neufeld, Christopher L Allison, Melissa M Reynolds
S-Nitrosothiols (RSNOs) such as S-nitrosoglutathione (GSNO) are known to produce nitric oxide (NO) through thermal, photolytic, and metal ion-promoted pathways, which has led to their increasing use as exogenous sources of therapeutic NO. Despite the burgeoning NO release applications for RSNOs, their susceptibility to metal-promoted decomposition has rarely been examined in a uniform manner through the specific measurement of NO release. In this study, the ability of various transition and post-transition metal ions to promote NO release from GSNO was surveyed by chemiluminescence-based NO detection...
January 7, 2019: Nitric Oxide: Biology and Chemistry
Natália Nóbrega, Natália Ferreira Araújo, Daniela Reis, Larissa Moreira Facine, Claudiane Aparecida S Miranda, Gianne Campos Mota, Rosária Dias Aires, Luciano Dos Santos Aggum Capettini, Jader Dos Santos Cruz, Daniella Bonaventura
The perivascular adipose tissue (PVAT) is located around the adventitia, composed primarily by adipocytes, stromal cells, leukocytes, fibroblasts and capillaries. It is well described that PVAT is an important modulator of the vascular tone being considered a biologically active tissue, releasing both vasoconstrictor and vasodilators factors. The literature shows that the anti-contractile effect induced by PVAT may be due to activation of the renin-angiotensin system (RAS). AIM: Investigate whether the renin-angiotensin system participates in the effect exerted by perivascular adipose tissue on the vascular tone...
January 3, 2019: Nitric Oxide: Biology and Chemistry
Debaprasad Koner, Bodhisattwa Banerjee, Rubaiya Hasan, Nirmalendu Saha
The facultative air-breathing magur catfish (Clarias magur) regularly encounter various environmental challenges including the exposure to nanomaterials discarded as industrial wastes in water bodies. The present investigation aimed at determining the possible ZnO NP-induced oxidative stress and also the antioxidant strategy of nitric oxide (NO), generated endogenously, in primary hepatocytes of magur catfish. Exposure of primary hepatocytes to different concentrations of ZnO NPs (5 and 10 μg/mL) led to a sharp rise of intracellular concentrations of hydrogen peroxide (H2 O2 ) and malondialdehyde (MDA) within 6 h, which decreased gradually at later stages...
December 31, 2018: Nitric Oxide: Biology and Chemistry
Milad Mohammadoo Khorasani, Fatemeh Karami Tehrani, Seyed Mohammad Reza Parizadeh, Morteza Atri
Extensive alterations in splicing is one of the molecular indicator for human cancers. Soluble guanylyl cyclase (sGC), an obligatory heterodimer, is composed of α1 and β1 subunits. Each subunit is encoded by a separate gene, GUCY1a3 and GUCY1b3, correspondingly. sGC activity has been regulated by an alternative splicing and it has an important effect on the breast cancer. sGC alternative splicing has been evaluated in the 55 malignant, 25 benign and 30 normal breast tissues using qRT-PCR and RT-PCR. The differences between groups were analyzed by Mann-Whitney U...
December 28, 2018: Nitric Oxide: Biology and Chemistry
Yanfeng Gao, Shuang Zhou, Yi Xu, Sen Sheng, Steven Y Qian, Xiongwei Huo
BACKGROUND: It has been widely accepted that angiogenesis plays fundamental roles in colorectal cancer development, and therapeutic targeting of this pathway has achieved promising outcome. Recent reports have highlighted the involvement of nitric oxide synthases (NOS) in the development of angiogenesis in cancer; however, the mechanism and therapeutic value of NOS inhibitors in colon cancer are largely unknown. OBJECTIVE: In this study, we investigated the effects and mechanism of the NOS inhibitors 1400W and L-NIO on the angiogenesis pathway in colorectal cancer cells...
December 24, 2018: Nitric Oxide: Biology and Chemistry
Seungho Choi, Nishant Saxena, Tajinder Dhammu, Mushfiquddin Khan, Avtar K Singh, Inderjit Singh, Jeseong Won
Nitric oxide (NO) synthesized by eNOS plays a key role in regulation of endothelial barrier integrity but underlying cell signaling pathway is not fully understood at present. Here, we report opposing roles of two different redox-dependent NO metabolites; peroxynitrite (ONOO-) vs. S-nitrosoglutathione (GSNO), in cell signaling pathways for endothelial barrier disruption. In cultured human brain microvessel endothelial cells (hBMVECs), thrombin induced F-actin stress fiber formation causes barrier disruption via activating eNOS...
December 24, 2018: Nitric Oxide: Biology and Chemistry
Jun Nan, Yaqing Liu, Chunjin Xu, Dahe Ge
BACKGROUND: Whether endothelial nitric oxide synthase (eNOS) polymorphisms are implicated in cancer development remains controversial. Therefore, we performed this study to obtain a more conclusive result on associations between eNOS polymorphisms and cancer. METHODS: Literature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: Forty-one studies were enrolled for analyses...
December 21, 2018: Nitric Oxide: Biology and Chemistry
Mauro Maniscalco, Salvatore Fuschillo, Carlo Gaudiosi, Alberto De Felice, Michele Martucci, Andrea Motta
Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. In this review, we will discuss the potential use of exhaled and nasal nitric oxide in the diagnosis of chronic chough...
December 14, 2018: Nitric Oxide: Biology and Chemistry
Anna B Solovieva, Anatoly F Vanin, Anatoly B Shekhter, Nikolay N Glagolev, Nadezhda A Aksenova, Vasak D Mikoyan, Svetlana L Kotova, Tatyana G Rudenko, Alexey Fayzullin, Peter S Timashev
We have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate - tryptophan - in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively...
December 14, 2018: Nitric Oxide: Biology and Chemistry
Jozef Kováčik, Sławomir Dresler, Giuseppe Micalizzi, Petr Babula, Juraj Hladký, Luigi Mondello
Metabolic responses of epiphytic lichen Ramalina farinacea to cadmium (Cd) and/or nitric oxide (NO) scavenger (cPTIO) were studied. Accumulation of Cd and other metallic nutrients was not affected by cPTIO while total and absorbed amounts differed. Cd-induced NO formation was suppressed by cPTIO but ROS signal was synergistically enhanced, confirming that NO is essential to keep ROS under control. This excessive ROS generation could be a reason for depleted amount of all fatty acids, including SFAs, MUFAs and PUFAs...
December 7, 2018: Nitric Oxide: Biology and Chemistry
Fernando E Padovan-Neto, Lauren Jurkowski, Conor Murray, Grace E Stutzmann, Mei Kwan, Afshin Ghavami, Vahri Beaumont, Larry C Park, Anthony R West
In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in corticostriatal circuits in HD, however, the impact of age and sex on nitrergic transmission is not well characterized. Thus, we utilized NADPH-diaphorase (NADPH-d) histochemistry and qPCR assays to assess neuronal NO synthase (nNOS) activity/expression in aged male and female Q175 heterozygous mice...
December 5, 2018: Nitric Oxide: Biology and Chemistry
Luke Liddle, Mia C Burleigh, Chris Monaghan, David J Muggeridge, Nicholas Sculthorpe, Charles R Pedlar, John Butcher, Fiona L Henriquez, Chris Easton
There is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metabolism which causes substantial inter-individual variability, within-person biological variation (CVB ), and analytical imprecision (CVA ) in experimental endpoints. However, no study has quantified the CVA and CVB of NO metabolites or the factors that influence their production. These data are important to calculate the critical difference (CD), defined as the smallest difference between sequential measurements required to signify a true change...
December 5, 2018: Nitric Oxide: Biology and Chemistry
Jordan E Balke, Ling Zhang, Justin M Percival
Defects in neuronal nitric oxide synthase (nNOS) splice variant localization and signaling in skeletal muscle are a firmly established pathogenic characteristic of many neuromuscular diseases, including Duchenne and Becker muscular dystrophy (DMD and BMD, respectively). Therefore, substantial efforts have been made to understand and therapeutically target skeletal muscle nNOS isoform signaling. The purpose of this review is to summarize recent salient advances in understanding of the regulation, targeting, and function of nNOSμ and nNOSβ splice variants in normal and dystrophic skeletal muscle, primarily using findings from mouse models...
November 29, 2018: Nitric Oxide: Biology and Chemistry
Soumya Mukherjee
The current review focuses on the significant role of nitric oxide (NO) in modulating ethylene-induced fruit ripening responses in plants. In this context, hydrogen sulfide (H2 S) and melatonin mediated crosstalk mechanisms have been discussed with recent updates. Physiological and biochemical events associated with climacteric fruit ripening involves a plethora of effects mediated by these biomolecules. In the last few years of progress in fruit ripening physiology, the involvement of hydrogen sulfide in relation to NO remains as a nascent field of research...
November 19, 2018: Nitric Oxide: Biology and Chemistry
Mingzheng Peng, Lei Qiang, Yan Xu, Cuidi Li, Tao Li, Jinwu Wang
The intracellular reactive oxygen species contribute to RANKL-induced osteoclastogenesis and osteolysis. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor, is critical in the cellular defense against oxidative stress by induction of antioxidants and cytoprotective enzymes. In the current study, it was first demonstrated that RANKL-induced osteoclastogenesis and hydroxylapatite resorption were suppressed by Corosolic acid (CA) via inhibiting p-JNK and activating p-AMPK...
November 16, 2018: Nitric Oxide: Biology and Chemistry
Selvaraj Vimalraj, Sivakamasundari Pichu, Thyagarajan Pankajam, Kasiviswanathan Dharanibalan, Valentin Djonov, Suvro Chatterjee
Angiogenesis is the formation of new blood vessels that occurs by two distinct processes following sprouting angiogenesis (SA) and intussusceptive angiogenesis (IA). Nitric oxide (NO) is known for its pro-angiogenic functions. However, no clear mechanisms are delineated on its role in promoting angiogenesis in reparative wound healing. We propose that NO regulates SA to IA transition and vice versa in wound milieu. We have used three models which include a new chick embryo extra-vasculature (CEV) burn wound model, adult Tie2-GFP transgenic Zebrafish caudal fin regeneration model and Zebrafish skin wound model to study the mechanisms underlying behind the role of NO in wound healing...
November 12, 2018: Nitric Oxide: Biology and Chemistry
Joana Leal, Luísa Teixeira-Santos, Dora Pinho, Joana Afonso, Jorge Carvalho, Maria de Lourdes Bastos, António Albino-Teixeira, Sónia Fraga, Teresa Sousa
We evaluated whether l-proline (Pro) supplementation improves redox status and nitric oxide (NO) bioavailability and prevents or delays angiotensin II (AngII)-induced hypertension. Male Sprague-Dawley rats were distributed to four experimental groups: Pro + AngII (Pro-Ang), Pro + Saline (Pro-Sal), Vehicle + AngII (Veh-Ang) and Veh + Saline (Veh-Sal). Pro solution (2 ·day-1 ) or water (vehicle) were orally administered, from day 0 to day 21. AngII (200 .min-1 ) or saline were infused (s...
November 10, 2018: Nitric Oxide: Biology and Chemistry
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