journal
MENU ▼
Read by QxMD icon Read
search

Nitric Oxide: Biology and Chemistry

journal
https://www.readbyqxmd.com/read/28216239/interaction-between-nitric-oxide-signaling-and-gap-junctions-during-ischemic-preconditioning-importance-of-s-nitrosylation-vs-protein-kinase-g-activation
#1
REVIEW
Fei Xie, Bing Rong, Tian-Cheng Wang, Li Hao, Ming-Jie Lin, Jing-Quan Zhong
No abstract text is available yet for this article.
February 12, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28216238/dinitrosyl-iron-complexes-with-natural-thiol-containing-ligands-in-aqueous-solutions-synthesis-and-some-physico-chemical-characteristics-a-methodological-review
#2
REVIEW
Anatoly F Vanin, Rostislav R Borodulin, Vasak D Mikoyan
Two approaches to the synthesis of dinitrosyl iron complexes (DNIC) with glutathione and l-cysteine in aqueous solutions based on the use of gaseous NO and appropriate S-nitrosothiols, viz., S-nitrosoglutathione (GS-NO) or S-nitrosocysteine (Cys-NO), respectively, are considered. A schematic representation of a vacuum unit for generation and accumulation of gaseous NO purified from the NO2 admixture and its application for obtaining aqueous solutions of DNIC in a Thunberg apparatus is given. To achieve this, a solution of bivalent iron in distilled water is loaded into the upper chamber of the Thunberg apparatus, while the thiol solution in an appropriate buffer (рН 7...
February 12, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28193486/post-translational-modifications-of-medicago-truncatula-glutathione-peroxidase-1-induced-by-nitric-oxide
#3
Claude Castella, Ioanna Mirtziou, Aurélie Seassau, Alexandre Boscari, Françoise Montrichard, Kalliopi Papadopoulou, Nicolas Rouhier, Alain Puppo, Renaud Brouquisse
Plant glutathione peroxidases (Gpx) catalyse the reduction of various peroxides, such as hydrogen peroxide (H2O2), phospholipid hydroperoxides and peroxynitrite, but at the expense of thioredoxins rather than glutathione. A main function of plant Gpxs is the protection of biological membranes by scavenging phospholipid hydroperoxides, but some Gpxs have also been associated with H2O2 sensing and redox signal transduction. Nitric oxide (NO) is not only known to induce the expression of Gpx family members, but also to inhibit Gpx activity, presumably through the S-nitrosylation of conserved cysteine residues...
February 10, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28185882/s-transnitrosation-reactions-of-hydrogen-sulfide-h2s-hs-s-2-with-s-nitrosated-cysteinyl-thiols-in-phosphate-buffer-of-ph-7-4-results-and%C3%A2-review-of-the-literature
#4
Dimitrios Tsikas, Anke Böhmer
Cysteine (CysSH) and its derivatives including N-acetylcysteine (NAC) and glutathione (GSH), and cysteine residues in proteins and enzymes are nitrosated with nitric oxide (NO) reaction products such as N2O3 to form S-nitrosated cysteine thiols (RCysSNO). RCysSNO undergo with cysteine thiols (RCysSH) S-transnitrosation reactions, thereby transferring reversibly their nitrosyl ((+)NO) group to RCysSH to form RCysSNO. (•)NO release from RCysSNO and S-transnitrosation are considered the most important features and signalling pathways of RCysSNO...
February 6, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28167162/disparate-response-to-microoxia-and-nitrogen-oxides-of-the-bradyrhizobium-japonicum-napedabc-nirk-and-norcbqd-denitrification-genes
#5
Emilio Bueno, Eloy F Robles, María J Torres, Tino Krell, Eulogio J Bedmar, María J Delgado, Socorro Mesa
Expression of the Bradyrhizobium japonicum napEDABC, nirK and norCBQD denitrification genes requires low oxygen (O2) tension and nitrate (NO3(-)), through a regulatory network comprised of two coordinated cascades, FixLJ-FixK2-NnrR and RegSR-NifA. To precisely understand how these signals are integrated in the FixLJ-FixK2-NnrR circuit, we analyzed β-Galactosidase activities from napE-lacZ, nirK-lacZ and norC-lacZ fusions and performed analyses of NapC and NorC levels as well as periplasmic nitrate reductase (Nap) activity, in B...
February 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28153714/validation-of-two-point-of-care-tests-against-standard-lab-measures-of-no-in-saliva-and-in-serum
#6
Ashwin Modi, Evangelia Morou-Bermudez, Jose Vergara, Rakesh Patel, Alexandria Nichols, Kaumudi Joshipura
No abstract text is available yet for this article.
January 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28137611/analgesic-effect-of-dimethyl-trisulfide-in-mice-is-mediated-by-trpa1-and-sst4-receptors
#7
Gábor Pozsgai, Maja Payrits, Éva Sághy, Réka Sebestyén-Bátai, Elise Steen, Éva Szőke, Zoltán Sándor, Margit Solymár, András Garami, Péter Orvos, László Tálosi, Zsuzsanna Helyes, Erika Pintér
TRPA1 receptors are calcium-permeable ligand-gated channels expressed in primary sensory neurons and involved in inflammation and pain. Activation of these neurons might have analgesic effect. Suggested mechanism of analgesic effect mediated by TRPA1 activation is the release of somatostatin (SOM) and its action on sst4 receptors. In the present study analgesic effect of TRPA1 activation on primary sensory neurons by organic trisulfide compound dimethyl trisulfide (DMTS) presumably leading to SOM release was investigated...
January 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28137609/dietary-nitrate-load-lowers-blood-pressure-and-renal-resistive-index-in-patients-with-chronic-kidney-disease-a-pilot-study
#8
Stephan Kemmner, Georg Lorenz, Jana Wobst, Thorsten Kessler, Ming Wen, Roman Günthner, Konrad Stock, Uwe Heemann, Klaus Burkhardt, Marcus Baumann, Christoph Schmaderer
Beetroot has a high concentration of inorganic nitrate, which can serially reduced to form nitrite and nitric oxide (NO) after oral ingestion. Increased renal resistive index (RRI) measured by Doppler ultrasonography is associated with higher cardiovascular mortality in hypertensive patients with reduced renal function over time defined as chronic kidney disease (CKD). Our aim was to investigate whether the supplementation of dietary nitrate by administration of beetroot juice is able to reduce blood pressure and renal resistive index (RRI) as prognostic markers for cardiovascular mortality in CKD patients...
January 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28137610/evidence-that-d-cysteine-protects-mice-from-gastric-damage-via-hydrogen-sulfide-produced-by-d-amino-acid-oxidase
#9
Luan Kelves M Souza, Thiago S L Araújo, Nayara A Sousa, Francisca Beatriz M Sousa, Kerolayne M Nogueira, Lucas A D Nicolau, Jand Venes R Medeiros
Hydrogen sulfide (H2S) is a signaling molecule in the gastrointestinal tract. H2S production can derive from d-cysteine via various pathways, thus pointing to a new therapeutic approach: delivery of H2S to specific tissues. This study was designed to evaluate the concentration and effects of H2S (generated by d-amino acid oxidase [DAO] from d-cysteine) in the gastric mucosa and the protective effects against ethanol-induced lesions in mice. Mice were treated with l-cysteine or d-cysteine (100 mg/kg per os)...
January 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28126499/bacillus-calmette-guerin-improves-local-and-systemic-response-to-radiotherapy-in-invasive-bladder-cancer
#10
Barbara Prack Mc Cormick, Denise Belgorosky, Yanina Langle, Natalia Balarino, Eduardo Sandes, Ana María Eiján
BACKGROUND: A key factor contributing to radio-resistance in conservative invasive bladder cancer (BCa) treatment is tumor hypoxia and a strategy to overcome it is to trigger the production of nitric oxide (NO). On the other hand, ionizing radiation (IR) applied to a primary tumor can induce immunogenic cell death which may set off a cytotoxic immune response against the primary tumor and its metastasis. PURPOSE: To study in vitro and in vivo, the role of BCG as a local sensitizer to overcome hypoxia-associated radio-resistance through the production of NO, and as an immune-stimulator to be used in combination with IR to generate a local tumor vaccine for invasive BCa treatment...
January 23, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28111306/thiolate-based-dinitrosyl-iron-complexes-decomposition-and-detection-and-differentiation-from-s-nitrosothiols
#11
Agnes Keszler, Anne R Diers, Zhen Ding, Neil Hogg
Dinitrosyl iron complexes (DNIC) spontaneously form in aqueous solutions of Fe(II), nitric oxide (NO), and various anions. They exist as an equilibrium between diamagnetic, dimeric (bi-DNIC) and paramagnetic, monomeric (mono-DNIC) forms. Thiolate groups (e.g., on glutathione or protein cysteine residues) are the most biologically relevant anions to coordinate to Fe(II). Low molecular weight DNIC have previously been suggested to be important mediators of NO biology in cells, and emerging literature supports their role in the control of iron-dependent cellular processes...
January 19, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28109803/shedding-light-on-no-homeostasis-light-as-a-key-regulator-of-glutathione-and-nitric-oxide-metabolisms-during-seedling-deetiolation
#12
Rafael Zuccarelli, Aline C P Coelho, Lazaro E P Peres, Luciano Freschi
Despite the significant impacts of light on nitric oxide (NO) levels in plants, the mechanism underlying the influence of this environmental factor on NO metabolism remains poorly understood. A critical mechanism controlling NO levels in plant cells relies on the S-nitrosylation of glutathione (GSH), giving rise to S-nitrosoglutathione (GSNO), which can be either stored or degraded depending on the cellular context. Here, we demonstrate that a strict balance is maintained between NO generation and scavenging during tomato (Solanum lycopersicum) seedling deetiolation...
January 18, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28087360/the-synthetic-peptide-pnpp-19-induces-peripheral-antinociception-via-activation-of-no-cgmp-katp-pathway-role-of-enos-and-nnos
#13
A C N Freitas, G C Silva, D F Pacheco, A M C Pimenta, V S Lemos, I D G Duarte, M E de Lima
BACKGROUND: and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6 (renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system. Since NO has been studied as an antinociceptive molecule and PnPP-19 is known to induce peripheral antinociception, we intended to evaluate whether PnPP-19 could induce peripheral antinociception through activation of this pathway. EXPERIMENTAL APPROACH: Nociceptive thresholds were measured by paw pressure test...
January 10, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28089828/nitrite-increases-glucose-stimulated-insulin-secretion-and-islet-insulin-content-in-obese-type-2-diabetic-male-rats
#14
Sevda Gheibi, Fatemeh Bakhtiarzadeh, Sajad Jeddi, Khadijeh Farrokhfall, Homeira Zardooz, Asghar Ghasemi
PURPOSE: Reduced bioavailability of nitric oxide (NO) is associated with pathogenesis of type 2 diabetes. Nitrite can act as a substrate for generation of systemic NO. The aim of this study was to examine the effects of nitrite administration on glucose-stimulated insulin secretion (GSIS) and islet insulin content in obese type 2 diabetic rats. METHODS: Male rats were divided into 4 groups: Control, control + nitrite, diabetes, and diabetes + nitrite. Sodium nitrite (50 mg/L in drinking water) was administered for 8 weeks...
January 9, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28069557/h2s-as-a-possible-therapeutic-alternative-for-the-treatment-of-hypertensive-kidney-injury
#15
REVIEW
George J Dugbartey
Hypertension is the most common cause of cardiovascular morbidities and mortalities, and a major risk factor for renal dysfunction. It is considered one of the causes of chronic kidney disease, which progresses into end-stage renal disease and eventually loss of renal function. Yet, the mechanism underlying the pathogenesis of hypertension and its associated kidney injury is still poorly understood. Moreover, despite existing antihypertensive therapies, achievement of blood pressure control and preservation of renal function still remain a worldwide public health challenge in a subset of hypertensive patients...
January 6, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28062279/nitric-oxide-induced-synthesis-of-hydrogen-sulfide-alleviates-osmotic-stress-in-wheat-seedlings-through-sustaining-antioxidant-enzymes-osmolyte-accumulation-and-cysteine-homeostasis
#16
M Nasir Khan, M Mobin, Zahid Khorshid Abbas, Manzer H Siddiqui
Nitric oxide (NO) and hydrogen sulfide (H2S) have been shown to act as signaling molecules in various physiological processes, play significant roles in plant cellular processes, and also mediate responses to both biotic and abiotic stresses in plants. The present investigation was carried out to test the effect of exogenous NO on endogenous synthesis of H2S in osmotic-stressed wheat (Triticum aestivum L.) seedlings. The results show that application of NO to wheat seedlings, suffered from PEG8000-induced osmotic stress, considerably enhanced the activities of H2S-synthesizing enzymes l-cysteine desulfhydrase (LCD) and d-cysteine desulfhydrase (DCD) leading to enhanced level of endogenous H2S content...
January 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28042082/beetroot-juice-versus-chard-gel-a-pharmacokinetic-and-pharmacodynamic-comparison-of-nitrate-bioavailability
#17
Luke C McIlvenna, Chris Monaghan, Luke Liddle, Bernadette O Fernandez, Martin Feelisch, David J Muggeridge, Chris Easton
Dietary supplementation with inorganic nitrate (NO3(-)) has been shown to induce a multitude of advantageous cardiovascular and metabolic responses during rest and exercise. While there is some suggestion that pharmacokinetics may differ depending on the NO3(-) source ingested, to the best of our knowledge this has yet to be determined experimentally. Here, we compare the plasma pharmacokinetics of NO3(-), nitrite (NO2(-)), and total nitroso species (RXNO) following oral ingestion of either NO3(-) rich beetroot juice (BR) or chard gels (GEL) with the associated changes in blood pressure (BP)...
December 29, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28039072/for-special-issue-on-no-in-plants-lead-induced-stress-which-triggers-the-production-of-nitric-oxide-no-and-superoxide-anion-o2-%C3%A2-in-arabidopsis-peroxisomes-affects-catalase-activity
#18
Francisco J Corpas, Juan B Barroso
Lead (Pb) contamination has a toxic effect on plant metabolisms, leading to a decrease in biomass production. The free radical nitric oxide (NO) is involved in the mechanism of response to a wide range of abiotic stresses. However, little is known about the interplay between Pb-induced stress and NO metabolism. Peroxisomes are sub-cellular compartments involved in multiple cellular metabolic pathways which are characterized by an active nitro-oxidative metabolism. Thus, Arabidopsis thaliana mutants expressing cyan fluorescent protein (CFP) through the addition of peroxisomal targeting signal 1 (PTS1), which enables peroxisomes to be visualized in vivo by confocal laser scanning microscopy (CLSM) combined with fluorescent probes for nitric oxide (NO), superoxide anion (O2(·-)) and peroxynitrite (ONOO(-)), were used to evaluate the potential involvement of these organelles in the mechanism of response to 150 μM lead-induced stress...
December 27, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28039071/function-of-s-nitrosoglutathione-reductase-gsnor-during-pepper-capsicum-annuum-l-fruit-ripening
#19
Marta Rodríguez-Ruiz, Paulo Mioto, José M Palma, Francisco J Corpas
Pepper (Capsicum annuum L.) is an annual plant species whose fruits undergo important metabolic changes through development and ripening. These changes include emission of volatile organic compounds associated with respiration, destruction of chlorophylls and synthesis of new pigments (red/yellow carotenoids plus xanthophylls and anthocyans) responsible for the color shift, protein degradation/synthesis, and changes in total soluble reducing equivalents. Previous data have shown that during the ripening of pepper fruit there was also an enhancement of protein tyrosine nitration...
December 27, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28030780/in%C3%A2-vitro-nitro-fatty-acid-release-from-cys-no2-fatty-acid-adducts-under-nitro-oxidative-conditions
#20
María N Padilla, Capilla Mata-Pérez, Manuel Melguizo, Juan B Barroso
Stress situations are characterized by a rise in reactive oxygen (ROS) and nitrogen (RNS) species levels. Nitro-fatty acids (NO2-FAs), or nitroalkenes, are produced by the interaction of RNS and unsaturated fatty acids, stored in cells, mostly as part of protein-adducted NO2-FAs, and are esterified in complex lipids. These molecules, which have been shown to play a pivotal role as anti-inflammatory and pro-survival players, have been widely characterized in animal systems. Recently, it has been reported that NO2-FAs play an important role in plant defense against several stress conditions...
December 25, 2016: Nitric Oxide: Biology and Chemistry
journal
journal
32780
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"