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Nitric Oxide: Biology and Chemistry

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https://www.readbyqxmd.com/read/28943473/h2s-is-a-key-antisecretory-molecule-against-cholera-toxin-induced-diarrhoea-in-mice-evidence-for-non-involvement-of-the-ac-camp-pka-pathway-and-ampk
#1
Francisca B M Sousa, Luan K M Souza, Nayara A Sousa, Thiago S L Araújo, Simone de Araújo, Dvison M Pacífico, Irismara S Silva, Renan O Silva, Lucas A D Nicolau, Fabiana M Souza, Marcelo C Filgueiras, Jefferson S Oliveira, Marcellus H L P Souza, Jand Venes R Medeiros
Hydrogen sulphide (H2S) is a gasotransmitter that participates in various physiological and pathophysiological processes within the gastrointestinal tract. We studied the effects and possible mechanism of action of H2S in secretory diarrhoea caused by cholera toxin (CT). The possible mechanisms of action of H2S were investigated using an intestinal fluid secretion model in isolated intestinal loops on anaesthetized mice treated with CT. NaHS and Lawesson's reagent and l-cysteine showed antisecretory activity through reduction of intestinal fluid secretion and loss of Cl(-) induced by CT...
September 21, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28943472/7-nitroindazol-loaded-nanoemulsions-preparation-characterization-and-its-improved-inhibitory-effect-on-nitric-oxide-synthase-1
#2
Clarissa Germano Barp, Cassiana Mendes, Elenara Lemos-Senna, Jamil Assreuy
Nitric oxide (NO) participates in several physiological processes such as maintenance of blood pressure, host defense, neurotransmission, inhibition of platelet aggregation and learning and memory. NO is also involved in several diseases or dysfunctions in the cardiovascular, central nervous and musculoskeletal systems. NO also has been shown to be a major player in sepsis. NOS-1-derived NO has been shown to be a relevant species in physiology but also is an important element in pathology. There exist some NOS-1 inhibitors and among of them, 7-nitroindazole has been used for its in vivo selectivity...
September 21, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28941934/effects-of-dietary-nitrate-supplementation-on-the-response-to-extremity-cooling-and-endothelial-function-in-individuals-with-cold-sensitivity-a-double-blind-placebo-controlled-crossover-randomised-control-trial
#3
Clare M Eglin, Joseph T Costello, Stephen J Bailey, Mark Gilchrist, Heather Massey, Anthony I Shepherd
Individuals with cold sensitivity have low peripheral skin blood flow and skin temperature possibly due to reduced nitric oxide (NO•) bioavailability. Beetroot has a high concentration of inorganic nitrate and may increase NO-mediated vasodilation. Using a placebo-controlled, double blind, randomised, crossover design, this study tested the hypotheses that acute beetroot supplementation would increase the rate of cutaneous rewarming following a local cold challenge and augment endothelium-dependent vasodilation in cold sensitive individuals...
September 20, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28939409/over-the-counter-mouthwash-use-and-risk-of-pre-diabetes-diabetes
#4
Kaumudi J Joshipura, Francisco J Muñoz-Torres, Evangelia Morou-Bermudez, Rakesh P Patel
AIMS: Over-the-counter mouthwash (most of which are antibacterial) comprises part of routine oral care for many; however, potential adverse effects of the long-term daily use have not been evaluated. Antibacterial mouthwash could destroy oral microbes critical for nitric oxide formation, and in turn predispose to metabolic disorders including diabetes. Our aim was to evaluate longitudinally the association between baseline over-the-counter mouthwash use and development of pre-diabetes/diabetes over a 3-year follow-up...
September 19, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28919322/changes-in-vasodilation-following-myocardial-ischemia-reperfusion-in-rats
#5
Sarah Brøgger Kristiansen, Majid Sheykhzade, Lars Edvinsson, Kristian Agmund Haanes
BACKGROUND: Blockage of a coronary artery, usually caused by arteriosclerosis, can lead to life threatening acute myocardial infarction. Opening with PCI (percutaneous coronary intervention), may be lifesaving, but reperfusion might exacerbate the cellular damage, and changes in the endothelium are believed to be involved in this worsened outcome. AIM: The aim of the present study was to compare endothelial dependent and independent vasodilatory effect after experimental myocardial ischemia/reperfusion (I/R)...
September 14, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28882669/real-time-visualization-of-distinct-nitric-oxide-generation-of-nitric-oxide-synthase-isoforms-in-single-cells
#6
Emrah Eroglu, Seth Hallström, Helmut Bischof, Marissa Opelt, Kurt Schmidt, Bernd Mayer, Markus Waldeck-Weiermair, Wolfgang F Graier, Roland Malli
The members of the nitric oxide synthase (NOS) family, eNOS, nNOS and iNOS, are well-characterized enzymes. However, due to the lack of suitable direct NO sensors, little is known about the kinetic properties of cellular NO generation by the different nitric oxide synthase isoenzymes. Very recently, we developed a novel class of fluorescent protein-based NO-probes, the geNOps, which allow real-time measurement of cellular NO generation and fluctuation. By applying these genetic NO biosensors to nNOS-, eNOS- and iNOS-expressing HEK293 cells we were able to characterize the respective NO dynamics in single cells that exhibited identical Ca(2+) signaling as comparable activator of nNOS and eNOS...
September 4, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28847570/the-interaction-of-l-cysteine-h2s-pathway-and-muscarinic-acetylcholine-receptors-machrs-in-mouse-corpus-cavernosum
#7
Fatma Aydinoglu, Fatma Tugce Dalkir, Hatice Oruc Demirbag, Nuran Ogulener
The aim of this study was to investigate the possible interaction of l-cysteine/H2S pathway and muscarinic acetylcholine receptors (mAChRs) in the mouse corpus cavernosum (CC). l-cysteine (endogenous H2S substrate; 10(-6)-10(-3) M), sodium hydrogen sulfide (NaHS; exogenous H2S; 10(-6)-10(-3) M) and acetylcholine (10(-9)-10(-4) M) produced concentration-dependent relaxation in isolated mouse CC tissues. Relaxations to endogenous and exogenous H2S were reduced by non-selective mAChR antagonist atropine (5 × 10(-5) M), selective M1 mAChR antagonist pirenzepine (5 × 10(-5) M) and selective M3 mAChR antagonist 4-DAMP (10(-7) M) but not by selective M2 mAChR antagonist AF-DX 116 (10(-6) M)...
August 25, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28821460/long-term-effects-of-hydrogen-sulfide-on-the-anabolic-catabolic-balance-of-articular-cartilage-in%C3%A2-vitro
#8
Á Vela-Anero, T Hermida-Gómez, L Gato-Calvo, C Vaamonde-García, S Díaz-Prado, R Meijide-Faílde, F J Blanco, E F Burguera
Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition of the synthesis of extracellular matrix (ECM) proteins, as well as an increase in proteases. This eventually leads to a predominance of the catabolic phenotype and the progressive loss of articular cartilage. Hydrogen sulfide (H2S) is a small gaseous molecule recognized as the third endogenous gasotransmitter...
August 15, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28804022/anti-obesity-and-anti-diabetic-effects-of-nitrate-and-nitrite
#9
REVIEW
Asghar Ghasemi, Sajad Jeddi
Prevalence of obesity is increasing worldwide and type 2 diabetes to date is the most devastating complication of obesity. Decreased nitric oxide bioavailability is a feature of obesity and diabetes that links these two pathologies. Nitric oxide is synthesized both by nitric oxide synthase enzymes from l-arginine and nitric oxide synthase-independent from nitrate/nitrite. Nitric oxide production from nitrate/nitrite could potentially be used for nutrition-based therapy in obesity and diabetes. Nitric oxide deficiency also contributes to pathogeneses of cardiovascular disease and hypertension, which are associated with obesity and diabetes...
August 10, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28797660/evaluation-of-genetic-effect-of-nos3-and-g%C3%A3-e-interaction-on-the-variability-of-serum-bilirubin-in-a-han-chinese-population
#10
Yingshui Yao, Zhengmei Fang, Song Yang, Hailong Zhao, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Lijun Zhu, Yuanrui Tian, Chong Shen
Bilirubin was shown to be related to the generation and functional exertion of endothelial nitric oxide synthase (eNOS) whilst the genetic effect of NOS3 on bilirubin variability was rarely reported. Herein we assessed the associations of three single nucleotide polymorphisms (SNPs) of NOS3 (rs4496877, rs1808593, and rs3918186) with bilirubin elevation in 2077 adults. The results showed that rs1808593 was significantly associated with bilirubin elevation, and odds ratios (ORs) of dominant model for the elevation of total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IDBIL) were 0...
August 8, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28782598/physiological-and-performance-effects-of-nitrate-supplementation-during-roller-skiing-in-normoxia-and-normobaric-hypoxia
#11
Linn Nybäck, Caroline Glännerud, Gustav Larsson, Eddie Weitzberg, Oliver Michael Shannon, Kerry McGawley
The present study examined the effects of acute nitrate (NO3(-)) supplementation ingested in the form of concentrated beetroot juice on cross-country roller-ski performance in normoxia (N) and normobaric hypoxia (H). Eight competitive cross-country skiers (five males: age 22 ± 3 years, V·O2max 71.5 ± 4.7 mL kg(-1)·min(-1); three females: age 21 ± 1 years, V·O2max 58.4 ± 2.5 mL kg(-1)·min(-1)) were supplemented with a single dose of NO3(-)-rich beetroot juice (BRJ, ∼13 mmol NO3(-)) or a NO3(-)-depleted placebo (PL, ∼0 mmol NO3(-)) and performed 2 x 6-min submaximal exercise bouts and a 1000-m time-trial (TT) on a treadmill in N (20...
August 4, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28757440/nitric-oxide-synthase-inhibition-impairs-muscle-regrowth-following-immobilization
#12
Andreo Fernando Aguiar, Ivan José Vechetti-Júnior, Rodrigo Wagner Souza, Warlen Pereira Piedade, Francis Lopes Pacagnelli, André Soares Leopoldo, Juliano Casonatto, Maeli Dal-Pai-Silva
Nitric oxide (NO) has been shown to increase skeletal muscle protein synthesis. However, the role of NO during skeletal muscle regrowth after immobilization remains unknown. The purpose of this study was to determine whether NO is required for muscle regrowth/recovery after a period of disuse by immobilization. Male Wistar rats were divided into 4 groups: recovered, 1-(2-trifluoromethyl-phenyl)-imidazole (TRIM; 10 mg·kg body mass(-1)·day(-1)), N(G)-nitro-l-arginine methyl ester (l-NAME; 90 mg·kg body mass(-1)·day(-1)), and control...
July 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28757441/exogenous-nitric-oxide-enhances-the-prophylactic-effect-of-aminoguanidine-a-preferred-inos-inhibitor-on-bleomycin-induced-fibrosis-in-the-lung-implications-for-the-direct-roles-of-the-no-molecule-in%C3%A2-vivo
#13
Chao Chen, Xiao-Jing Yun, Li-Ze Liu, Hong Guo, Lian-Feng Liu, Xiao-Ling Chen
OBJECTIVE: Inducible nitric oxide synthase (iNOS) aggravates and endothelial nitric oxide synthase (eNOS) ameliorates fibrosis in the lung. Our previous study demonstrated that aminoguanidine (AG), a preferred iNOS inhibitor, prevents bleomycin-induced injury and fibrosis in the lung. The diethylenetriamine nitric oxide adduct (DETA/NO) is a slow-release NO donor. Here, to clarify the exact role of the nitric oxide (NO) molecule in the pathogenesis of pulmonary fibrosis in vivo, we observed the effects of inhalation of aerosolized DETA/NO on fibrosis in the lungs of bleomycin-exposed rats with AG treatment, including the effects on the myofibroblast number, collagen deposition, peroxynitrite anion (ONOO(-)) formation, and injury in the lung...
July 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28743484/oxidative-stress-enhances-and-modulates-protein-s-nitrosation-in-smooth-muscle-cells-exposed-to-s-nitrosoglutathione
#14
E Belcastro, W Wu, I Fries-Raeth, A Corti, A Pompella, P Leroy, I Lartaud, C Gaucher
Among S-nitrosothiols showing reversible binding between NO and -SH group, S-nitrosoglutathione (GSNO) represents potential therapeutics to treat cardiovascular diseases (CVD) associated with reduced nitric oxide (NO) availability. It also induces S-nitrosation of proteins, responsible for the main endogenous storage form of NO. Although oxidative stress parallels CVD development, little is known on the ability of GSNO to restore NO supply and storage in vascular tissues under oxidative stress conditions. Aortic rat smooth muscle cells (SMC) were stressed in vitro with a free radical generator (2,2'-azobis(2-amidinopropane) dihydrochloride, AAPH)...
July 23, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28709848/hydrogen-sulfide-alleviates-placental-injury-induced-by-maternal-cigarette-smoke-exposure-during-pregnancy-in-rats
#15
Fusheng Zhao, Fang Lei, Senfeng Zhang, Xiang Yan, Wen Wang, Yu Zheng
Maternal cigarette smoke exposure (CSE) during pregnancy is a well recognized causative factor for placental injury. Hydrogen sulfide (H2S), a gaseous signal molecule, has been shown to exert a protective effect against tissue injury in many organs. This study aimed to investigate whether H2S could alleviate CSE-induced placental injury in rats. Pregnant SD rats were randomly divided into 4 groups: NaCl, CSE, CSE + NaHS (a donor of H2S) and NaHS. On gestational day 21, placental weight was measured. Placental H2S content was assessed by methylene blue method...
July 11, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28684191/effects-of-oral-sodium-nitrate-on-forearm-blood-flow-oxygenation-and-exercise-performance-during-acute-exposure-to-hypobaric-hypoxia-4300%C3%A2-m
#16
Heath G Gasier, Anthony R Reinhold, Allison R Loiselle, Shawn E Soutiere, David M Fothergill
A reduction in oxygen transport contributes to impaired exercise capacity at high altitude. Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance. In a double-blind, randomized crossover study, 10 healthy subjects (9 males and 1 female) performed continuous (CGrip) and repeated rhythmic (RGrip) isometric forearm exercise until task failure in normobaric normoxia (NN), 2...
July 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28549665/effects-of-supervised-exercise-and-dietary-nitrate-in-older-adults-with-controlled-hypertension-and-or-heart-failure-with-preserved-ejection-fraction
#17
Hossam A Shaltout, Joel Eggebeen, Anthony P Marsh, Peter H Brubaker, Paul J Laurienti, Jonathan H Burdette, Swati Basu, Ashley Morgan, Patricia C Dos Santos, James L Norris, Timothy M Morgan, Gary D Miller, W Jack Rejeski, Amret T Hawfield, Debra I Diz, J Thomas Becton, Daniel B Kim-Shapiro, Dalane W Kitzman
Aerobic exercise training is an effective therapy to improve peak aerobic power (peak VO2) in individuals with hypertension (HTN, AHA/ACC class A) and heart failure patients with preserved ejection fraction (HFpEF). High nitrate containing beetroot juice (BRJ) also improves sub-maximal endurance and decreases blood pressure in both HTN and HFpEF. We hypothesized that combining an aerobic exercise and dietary nitrate intervention would result in additive or even synergistic positive effects on exercise tolerance and blood pressure in HTN or HFpEF...
September 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28693805/editorial-nitric-oxide-in-plants
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28450187/nitrosoamphetamine-binding-to-myoglobin-and-hemoglobin-crystal-structure-of-the-h64a-myoglobin-nitrosoamphetamine-adduct
#19
Bing Wang, Samantha M Powell, Ye Guan, Nan Xu, Leonard M Thomas, George B Richter-Addo
N-hydroxyamphetamine (AmphNHOH) is an oxidative metabolite of amphetamine and methamphetamine. It is known to form inhibitory complexes upon binding to heme proteins. However, its interactions with myoglobin (Mb) and hemoglobin (Hb) have not been reported. We demonstrate that the reactions of AmphNHOH with ferric Mb and Hb generate the respective heme-nitrosoamphetamine derivatives characterized by UV-vis spectroscopy. We have determined the X-ray crystal structure of the H64A Mb-nitrosoamphetamine complex to 1...
July 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28655650/mechanical-wounding-promotes-local-and-long-distance-response-in-the-halophyte-cakile-maritima-through-the-involvement-of-the-ros-and-rns-metabolism
#20
Hayet Houmani, Marta Rodríguez-Ruiz, José M Palma, Francisco J Corpas
Mechanical wounding in plants, which are capable of generating defense responses possibly associated with nitro-oxidative stress, can be caused by (a)biotic factors such as rain, wind, herbivores and insects. Sea rocket (Cakile maritima L.), a halophyte plant belonging to the mustard family Brassicaceae, is commonly found on sandy coasts throughout Europe. Using 7-day-old Cakile maritima L. seedlings, mechanical wounding was induced in hypocotyls by pinching with a striped-tip forceps; after 3 h, several biochemical parameters were analyzed in both the damaged and unwounded organs (green cotyledons and roots)...
June 24, 2017: Nitric Oxide: Biology and Chemistry
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