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Nitric Oxide: Biology and Chemistry

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https://www.readbyqxmd.com/read/28527627/a-kinetic-study-on-the-reactivity-of-azanone-hno-toward-its-selected-scavengers-insight-into-its-chemistry-and-detection
#1
Renata Smulik-Izydorczyk, Adrianna Mesjasz, Angelika Gerbich, Jan Adamus, Radosław Michalski, Adam Sikora
Recently, azanone (HNO), which is the protonated one-electron reduction product of (·)NO, has gained considerable attention due to its unique pharmacological effects. Although there has been much progress in understanding HNO biology and chemistry, it remains the most elusive reactive nitrogen species. Herein, we applied the competition kinetics method, based on two parallel HNO reactions with the different scavengers and molecular oxygen (kO2 = (1.8 ± 0.3) × 10(4) M(-1) s(-1)), to determine the rate constants for the reactions of HNO with its selected co-reactants...
May 17, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28522342/acute-and-repeated-exposure-with-the-nitric-oxide-no-donor-sodium-nitroprusside-snp-differentially-modulate-responses-in-a-rat-model-of-anxiety
#2
Martha A Orfanidou, Anastasios Lafioniatis, Aikaterini Trevlopoulou, Ntilara Touzlatzi, Nikolaos Pitsikas
The nitric oxide (NO) donor sodium nitroprusside (SNP) actually is under investigation for the treatment of schizophrenia. That anxiety disorders are noted to occur commonly in schizophrenia patients is known. Contradictory results were reported however, concerning the effects of SNP in animal models of anxiety disorders. The present study investigated the effects of acute and repeated administration of SNP on anxiety-like behaviour in rats assessed in the light/dark test. The effects of SNP on motility in a locomotor activity chamber were also investigated in rats...
May 15, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28483702/polysubstituted-4-6-bis-hetero-arylpyrimidines-as-dual-inhibitors-of-nitric-oxide-and-prostaglandin-e2-production
#3
Viktor Kolman, Petr Jansa, Filip Kalčic, Zlatko Janeba, Zdeněk Zídek
As a part of our extensive structure-activity relationship study of anti-inflammatory heterocycles, a novel series of 67 polysubstituted 2-aminopyrimidines was prepared bearing one (at the C-4 position of the pyrimidine ring) or two (in the C-4 and C-6 positions) (hetero)aryl substituents attached directly through the C-C bond. The key synthetic steps involved either Suzuki-Miyaura or Stille cross-coupling reactions carried out on easily available 4,6-dichloropyrimidines. All prepared compounds, except one, were able to inhibit immune-activated production of nitric oxide (NO) significantly...
May 5, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28478280/construction-of-valence-bond-structures-for-feno-7-nitrosyl-heme-and-non-heme-complexes
#4
Richard D Harcourt
For {FeNO}(7) nitrosyl heme and non-heme complexes, with 17 valence shell electrons, Fe(II)NO, Fe(II)NO* and Fe(III)NO(-) valence bond structures of the increased-valence type are generated primarily from Lewis valence bond structures by delocalizing non-bonding electrons into diatomic bonding molecular orbitals. A valence bond formulation for the reaction 2MbNO + 2H(+) → 2metMb + N2O + H2O is also presented.
May 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28456602/an-update-on-nitric-oxide-and-its-benign-role-in-plant-responses-under-metal-stress
#5
REVIEW
Seema Sahay, Meetu Gupta
Pollution due to heavy metal(loid)s has become common menace across the globe. This is due to unprecedented frequent geological changes coupled with increasing anthropogenic activities, and population growth rate. Heavy metals (HMs) presence in the soil causes toxicity, and hampers plant growth and development. Plants being sessile are exposed to a variety of stress and/or a network of different kinds of stresses throughout their life cycle. To sense and transduce these stress signal, the signal reactive nitrogen species (RNS) particularly nitric oxide (NO) is an important secondary messenger next to only reactive oxygen species (ROS)...
April 26, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28450188/hydrogen-sulfide-attenuates-cardiac-injury-in-takotsubo-cardiomyopathy-by-alleviating-oxidative-stress
#6
Zhihong Zhang, Sheng Jin, Xu Teng, Xiaocui Duan, Yuhong Chen, Yuming Wu
Takotsubo cardiomyopathy (TCM) is characterized by transient left ventricular apical ballooning with the absence of coronary occlusion, which is an acute cardiac syndrome with substantial morbidity and mortality. It was reported that reduced endogenous hydrogen sulfide (H2S) levels may be related to various heart diseases. The present study investigated the mechanism by which H2S administration modulates and protects cardiac function in TCM rats. In order to establish a TCM model, Sprague Dawley (SD) rats were injected with a single dose of β-adrenergic agonist isoprenaline (ISO)...
April 24, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28450187/nitrosoamphetamine-binding-to-myoglobin-and-hemoglobin-crystal-structure-of-the-h64a-myoglobin-nitrosoamphetamine-adduct
#7
Bing Wang, Samantha M Powell, Ye Guan, Nan Xu, Leonard M Thomas, George B Richter-Addo
N-hydroxyamphetamine (AmphNHOH) is an oxidative metabolite of amphetamine and methamphetamine. It is known to form inhibitory complexes upon binding to heme proteins. However, its interactions with myoglobin (Mb) and hemoglobin (Hb) have not been reported. We demonstrate that the reactions of AmphNHOH with ferric Mb and Hb generate the respective heme-nitrosoamphetamine derivatives characterized by UV-vis spectroscopy. We have determined the X-ray crystal structure of the H64A Mb-nitrosoamphetamine complex to 1...
April 24, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28438687/dietary-nitrite-supplementation-attenuates-cardiac-remodeling-in-l-name-induced-hypertensive-rats
#8
Kunihiro Sonoda, Kazuo Ohtake, Hiroyuki Uchida, Junta Ito, Masaki Uchida, Hideshi Natsume, Hazuki Tamada, Jun Kobayashi
Loss of nitric oxide (NO) bioavailability underlies the development of hypertensive heart disease. We investigated the effects of dietary nitrite on N(G)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension. Sprague-Dawley rats were divided into five groups: an untreated control group, an l-NAME-treated group, and three other l-NAME-treated groups supplemented with 10 mg/L or 100 mg/L of nitrite or 100 mg/L of captopril in drinking water. After the 8-week experimental period, mean arterial blood pressure was measured, followed by sampling of blood and heart tissue for assessment of nitrite/nitrate levels in the plasma and heart, the plasma level of angiotensin II (AT II), and the heart transcriptional levels of AT II type 1 receptor (AT1R), transforming growth factor-β1 (TGF-β1), and connective tissue proteins such as type 1 collagen and fibronectin...
April 21, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28433823/simultaneous-monitoring-of-intra-and-extracellular-nitric-oxide-in-living-cells-by-means-of-dual-color-fluorescence-imaging
#9
Hui-Wen Yao, Jian-Bo Chen, Xiao-Feng Guo, Hong Wang
A dual-color fluorescence imaging method for simultaneous monitoring of intra- and extracellular nitric oxide (NO) was developed. Assisted by confocal laser scanning microscope, the intra- and extracellular NO can be successfully visualized by using two selected probes, 4,4-difluoro-8-(3,4-diaminophenyl)-3,5-bis(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene (p-MOPB) and disodium 2,6-disulfonate-1,3-dimethyl-5-hexadecyl-8-(3,4-diaminophenyl)-4,4'-difluoro-4-bora-3a,4a-diaza-s-indacene (DSDMHDAB), which display distinct membrane permeability and show different colors of fluorescence after reaction with NO...
April 20, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28414104/the-role-of-enos-on-the-compensatory-regulation-of-vascular-tonus-by-h2s-in-mouse-carotid-arteries
#10
Elif Ertuna, Annemarieke E Loot, Ingrid Fleming, Gunay Yetik-Anacak
The gasotransmitter nitric oxide (NO) has an important role in vascular function and a decrease in its bioavailability is accepted as a main pathological mechanism for cardiovascular diseases. However, other gasotransmitters such as hydrogen sulfide (H2S) are also generated by the endothelium and can also affect vascular tone and a crosstalk may exist between H2S and NO. We therefore investigated the consequences of deficiency, replacement or overexpression of endothelial nitric oxide synthase (eNOS) on H2S-induced vascular responses in murine carotid arteries...
April 13, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28414103/apoptosis-induction-of-poly-s-nitrosated-human-serum-albumin-in-resistant-solid-tumor-under-hypoxia-can-be-restored-by-phosphodiesterase-5-inhibition
#11
Mayumi Ikeda, Yu Ishima, Victor T G Chuang, Tsuyoshi Ikeda, Ryo Kinoshita, Hiroshi Watanabe, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama
Poly-S-nitrosated human serum albumin (Poly-SNO-HSA) delivered and accumulated nitric oxide (NO) in tumors and induces apoptosis. Tumor hypoxia is strongly associated with malignant progression and tumor resistance to therapy. In this study, we examined the cytotoxic effect of Poly-SNO-HSA under hypoxia on the murine colon 26 adenocarcinoma (C26) cells in vitro and in vivo. Under hypoxia, at about 4 times LD50 dose of Poly-SNO-HSA in vitro, the reactive oxygen species production was hindered but apoptotic cells were induced via cGMP pathway as the effect was suppressed by a soluble guanylate cyclase inhibitor, NS2028...
April 13, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28412475/potential-anti-inflammatory-effect-of-lqfm-021-in-carrageenan-induced-inflammation-the-role-of-nitric-oxide
#12
Iziara F Florentino, Daiany P B Silva, Dayane M Silva, Carina Sofia Cardoso, André L E Moreira, Clayton L Borges, Célia M de A Soares, Pablinny M Galdino, Luciano M Lião, Paulo C Ghedini, Ricardo Menegatti, Elson A Costa
The pyrazole compound LQFM-021 exhibits vasorelaxant, antinociceptive and anti-inflammatory activities. Furthermore, it has low toxicity, indicating that this compound may be considered to be a good prototype for the development of new analgesic/anti-inflammatory drugs. Therefore, the aim of this study was to investigate the potential anti-inflammatory activity of LQFM-021 using a model of carrageenan-induced inflammation as well as the mechanism of action and role of nitric oxide in this effect. Acute treatments with LQFM-021 (30 and 60 mg/kg p...
April 12, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28392448/effect-of-nitric-oxide-to-axonal-degeneration-in-multiple-sclerosis-via-downregulating-monocarboxylate-transporter-1-in-oligodendrocytes
#13
REVIEW
Xiaoyi Tang, Minghong Lan, Mao Zhang, Zhongxiang Yao
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Axonal degeneration, one of the main pathological characteristics of MS, is affected by nitric oxide (NO). In turn, NO induces mitochondrial dysfunction of neurons and glial cells. Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. The condition gradually leads to axonal degeneration...
April 7, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28392446/the-asymmetric-dimethylarginine-mediated-inhibition-of-nitric-oxide-in-the-rostral-ventrolateral-medulla-contributes-to-regulation-of-blood-pressure-in-hypertensive-rats
#14
Xing Tan, Ji-Kui Li, Jia-Cen Sun, Pei-Lei Jiao, Yang-Kai Wang, Zhao-Tang Wu, Bing Liu, Wei-Zhong Wang
Nitric oxide (NO) contributes to the central control of cardiovascular activity. The rostral ventrolateral medulla (RVLM) has been recognized as a pivotal region for maintaining basal blood pressure (BP) and sympathetic tone. It is reported that asymmetric dimethylarginine (ADMA), characterized as a cardiovascular risk marker, is an endogenous inhibitor of nitric oxide synthesis. The present was designed to determine the role of ADMA in the RVLM in the central control of BP in hypertensive rats. In Sprague Dawley (SD) rats, microinjection of ADMA into the RVLM dose-dependently increased BP, heart rate (HR), and renal sympathetic never activity (RSNA), but also reduced total NO production in the RVLM...
April 7, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28392447/s-nitrosation-of-calpains-is-associated-with-cardioprotection-in-myocardial-i-r-injury
#15
Matthias Totzeck, Sebastian Korste, Ilkka Miinalainen, Ulrike B Hendgen-Cotta, Tienush Rassaf
BACKGROUND: Myocardial infarction remains the single leading cause of death worldwide. Upon reperfusion of occluded arteries, deleterious cellular mediators particularly located at the mitochondria level can be activated, thus limiting the outcome in patients. This may lead to the so-called ischemia/reperfusion (I/R) injury. Calpains are cysteine proteases and mediators of caspase-independent cell death. Recently, they have emerged as central transmitters of cellular injury in several cardiac pathologies e...
April 6, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28315469/nitric-oxide-dioxygenase-and-peroxidase-activity-of-arabidopsis-phytoglobin3-and-its-potential-role-in-pathogen-defense
#16
Nitika Mukhi, Suman Kundu, Jagreet Kaur
Phytoglobin 3 appears to be ubiquitous in plants, yet there has been dearth of evidence for their potent physiological functions. Previous crystallographic studies suggest a potent NO dioxygenase activity of Arabidopsis phytoglobin 3 (AHb3). The present work examined the in vivo function of AHb3 in plant physiology and its role in biotic stress using Arabidopsis- Sclerotinia sclerotorium pathosystem. The gene was found to be ubiquitously expressed in all plant tissues, with moderately increased expression in roots...
March 14, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28274830/alternative-fluorimetric-based-method-to-detect-and-compare-total-s-nitrosothiols-in-plants
#17
Paulo Tamaso Mioto, Marta Rodríguez-Ruiz, Augustin Catalin Mot, Rafael Zuccarelli, Francisco J Corpas, Luciano Freschi, Helenice Mercier
Nitric oxide (NO) is an important signaling molecule occurring in virtually all organisms, whose mechanism of action relies mainly on its interaction with proteins or peptides by nitrosylation, forming compounds such as S-nitrosothiols (SNO). The Saville reaction and the ozone-based chemiluminescence method are the main techniques used for nitrosylated protein quantification. While the Saville assay is not very sensitive, the ozone-based chemiluminescence is expensive and time-consuming. Here we propose a method in which the protein-bound NO groups are exposed to UV light, cleaving the bond and allowing the quantification of the derived NO molecules by diamino-rhodamine (DAR) dyes...
March 6, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28257997/carbon-monoxide-does-not-contribute-to-vascular-tonus-improvement-in-exercise-trained-rats-with-chronic-nitric-oxide-synthase-inhibition
#18
Seher Nasırcılar Ülker, Günnur Koçer, Ümit Kemal Şentürk
Carbon monoxide (CO), an end product of heme oxygenase (HO) that is involved in the regulation of vascular tonus, may show a compensatory effect in nitric oxide (NO) deficiency. This study aimed to assess the effect of the HO/CO system on the vascular tone in exercise-trained rats with hypertension induced by chronic NO synthase (NOS) inhibition. Hypertension was induced by N-nitro-l-arginine methyl ester (25 mg/kg/day in drinking water), and exercise training comprised swimming 1 h/day, 5 days/week, for 6 weeks...
March 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28390999/measuring-nitrate-reductase-activity-from-human-and-rodent-tongues
#19
Khandaker A Ahmed, Alexandria L Nichols, Jaideep Honavar, Mark T Dransfield, Sadis Matalon, Rakesh P Patel
Reduction of salivary nitrate to nitrite by oral microbes expressing nitrate-reductase has emerged as a crucial pathway in systemic NO homeostasis in humans and other mammals. Selective depletion of oral microbes prevents dietary nitrate-dependent lowering of blood pressure, inhibition of platelet aggregation and ischemic injury. To date, most studies interrogate enterosalivary nitrate reduction by following changes in saliva or plasma nitrite and NO-signaling (functional) end points. Little is known about whether, and if so how, nitrate-reductase enzymatic activity per se (i...
June 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28315470/the-nitric-oxide-synthase-2-pathway-is-targeted-by-both-pro-and-anti-inflammatory-treatments-in-the-immature-human-intestine
#20
Emanuela Ferretti, Eric Tremblay, Marie-Pier Thibault, David Grynspan, Karolina M Burghardt, Marcos Bettolli, Corentin Babakissa, Emile Levy, Jean-François Beaulieu
BACKGROUND AND AIM: NO synthase 2 (NOS2) was recently identified as one the most overexpressed genes in intestinal samples of premature infants with necrotizing enterocolitis (NEC). NOS2 is widely implicated in the processes of epithelial cell injury/apoptosis and host immune defense but its specific role in inflammation of the immature human intestinal mucosa remains unclear. Interestingly, factors that prevent NEC such as epidermal growth factor (EGF) attenuate the inflammatory response in the mid-gestation human small intestine using serum-free organ culture while drugs that are associated with NEC occurrence such as the non-steroidal anti-inflammatory drug, indomethacin (INDO), exert multiple detrimental effects on the immature human intestine...
June 1, 2017: Nitric Oxide: Biology and Chemistry
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