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Clinical Hemorheology and Microcirculation

Shiyun Peng, Hong Ding, Tiantian Fu, Bengang Wang, Wenping Wang, Jinzhu Zhou
BACKGROUND: Savitzky-Golay filter is a digital filter used in data smoothing, we introduced a contrast-enhanced ultrasound (CEUS) quantification software based on the filter (SGCQ). OBJECTIVE: To explore the methodology of analyzing hepatic tumors hemodynamics applying SGCQ software and the correlation between SGCQ parameters and hepatocellular carcinoma (HCC) angiogenesis. METHODS: Nighty-seven right-lobe located hepatic mass cases (15 females and 82 males, mean age 58±10y, mean lesion size: 39...
August 4, 2018: Clinical Hemorheology and Microcirculation
Kristina Blaslov, Ivan Kruljac, Gorana Mirošević, Petar Gaćina, Slobodanka Ostojić Kolonić, Milan Vrkljan
BACKGROUNDAlthough it is considered that the pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) is primarily due to chronic hyperglycemia resulting in vascular changes and retinal ischemia, the red blood cells (RBCs) disorders might also represent an important pathophysiological risk factor.OBJECTIVETo evaluate whether the RBC properties contribute to DR development and progression in T2DM.METHODSThis prospective observational study comprised 247 persons with T2DM free of DR or with non proliferative DR without any signs of anaemia...
July 30, 2018: Clinical Hemorheology and Microcirculation
Vera Lachmann, Marc Heimann, Christian Jung, Tobias Zeus, Pablo Emilio Verde, Malte Kelm, Florian Bönner
AIMThe study aims to test whether simultaneous measurement of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) is feasible, safe and effective during regadenoson-induced hyperemia.METHODS AND RESULTSFFR, CFR and IMR were measured simultaneously during regadenoson (Rapiscan 400μg) -induced hyperemia in 50 patients with stable coronary artery disease with a SYNTAX score of <22. Simultaneous measurement of FFR, CFR and IMR was technically feasible in all cases (50/50)...
July 30, 2018: Clinical Hemorheology and Microcirculation
Mazhar Mushtaq, Muhammad Abdul Mateen, Uh-Hyun Kim
BACKGROUND: The viscosity of a fluid is a measure of its resistance. It is the thickness and stickiness of blood, and a direct measure of the resistance of blood to flow through the vessels. Various factors in the blood have direct or indirect impact on blood viscosity. These hemorheological factors play an important role in the pathogenesis of many diseases. Glucose is one such factor, which, when increased in the blood, causes resistance in the blood flow. OBJECTIVE: The present study is aimed to assess the changes in blood viscosity associated with hyperglycemia in rodents...
July 20, 2018: Clinical Hemorheology and Microcirculation
Wen-Tao Kong, Min Tang, Yu-Dong Qiu, Jiong Shi, Min Wu
OBJECTIVE: To compare the enhancement pattern of hepatic angiomyolipoma (HAML) on contrast enhanced ultrasound (CEUS) and magnetic resonance (MR). METHODS: The data of seven patients (females; age 28-52 years; mean, 42 years) with histologically proven HAMLs were retrospectively reviewed. All patients underwent CEUS and MR examination. The images were analyzed by two experienced doctors who blinded to the clinical and pathological information of cases. RESULTS: The mean diameter of the nodule was 5...
July 13, 2018: Clinical Hemorheology and Microcirculation
Okan Arihan, Samiye Ciftci Yabanoglu, Gulberk Ucar, Neslihan Dikmenoglu Falkmarken
BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs), antidepressants commonly used in cardiovascular diseases (CVDs), inhibit the re-uptake of serotonin not only into neurons but also into platelets. Hence they increase the level of serotonin in plasma. OBJECTIVE: This study was aimed to clarify the effects of two selected SSRIs on plasma serotonin level, hemorheological parameters (hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity) and selected oxidative stress markers (MDA, GSH, GSSG levels in plasma and erythrocytes)...
July 11, 2018: Clinical Hemorheology and Microcirculation
Ismail Hakki Akbudak, Vural Kucukatay, Ozgen Kilic-Erkek, Yasin Ozdemir, Melek Bor-Kucukatay
BACKGROUND: Ozone is used intensively worldwide in treatment and research of various pathologies due to its healing effects. OBJECTIVE: The aim of this study is to investigate the effect of major ozone autohemotherapy on erythrocyte deformability and aggregation. METHODS: 10 and 50μg/ml doses of ozone was applied for 20 minute to venous blood samples obtained from 10 healthy male volunteers. Erythrocyte aggregation, deformability were measured by an ektacytometer...
June 9, 2018: Clinical Hemorheology and Microcirculation
Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Balazs Szabo, Adam Deak, Norbert Nemeth
BACKGROUND: Arteriovenous fistula (AVF) may affect erythrocytes through many pathways (e.g., mechanical, inflammatory). However, these effects haven't been elucidated completely yet. OBJECTIVE: To follow-up the hemorheological and the hematological changes in the presence of artificial carotid-jugular fistula in rats. METHODS: Female Wistar rats were subjected to sham-operated group (SG, n = 6) and to fistula group (FG, n = 10). Under general anesthesia, the right carotid artery and jugular vein were isolated via a neck incision, and in the FG carotid-jugular fistula was performed by microsurgical techniques Hematological variables, red blood cell (RBC) deformability and membrane (mechanical) stability parameters were determined before operation and on the 1st and 6th postoperative weeks...
June 9, 2018: Clinical Hemorheology and Microcirculation
Anna Wärme, Ursula Hadimeri, Henrik Hadimeri, Salmir Nasic, Bernd Stegmayr
BACKGROUND: A native AV-fistula (AVF) for access in hemodialysis (HD) is preferable. Stenosis, a major hurdle, is associated with older age and diabetes mellitus. PURPOSE: This case-control study aimed to clarify if any medical and/or laboratory factors, that can be altered, could be associated to AVF stenosis. METHODS: 33 patients with a patent AVF without need of intervention during a two year period (Controls) were matched by diagnosis and age with 33 patients (Cases), that had at least one radiological invasive examination/intervention due to suspected AVF malfunction (case-control mode 2:1)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Jens Rothenberger
BACKGROUND: Improvement of skin microcirculation would be beneficial in transplanted tissues and thus, there is a demand for effective, reliable and harmless angiogenic treatments. The aim of this study was to assess the effect of capsaicin application (CA), the remote effect of capsaicin application (REC), the impact of remote ischemic conditioning (RIC), and the impact of combined remote ischemic conditioning with capsaicin application (Comb) on human skin microcirculation. METHODS: Perfusion changes were assessed using a laser Doppler device (easyLDI, Aimago Lausanne)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Sebastian Yu, Stephen Chu-Sung Hu, Hsin-Su Yu, Yi-Ying Chin, Yang-Chun Cheng, Chih-Hung Lee
BACKGROUND: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be normal during early stage of microangiopathy in SSc. OBJECTIVE: We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. METHODS: A 67-year-old male came with multiple ulcerations on his fingers for one year...
June 5, 2018: Clinical Hemorheology and Microcirculation
Andrea Bagno, Romeo Martini
The words "Translational" and "Medicine" have been recently coupled to indicate a combination of disciplines, resources, expertise, and techniques aimed at enhancing prevention, diagnosis, and therapies. As stated in 2015 by the European Society for Translational Medicine, translational medicine is "an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community". By definition, Translational Medicine is a highly interdisciplinary field, which gathers several specialties aimed at improving the global healthcare system...
May 25, 2018: Clinical Hemorheology and Microcirculation
Maciej Wiewiora, Anna Mertas, Alicja Nowowiejska-Wiewiora, Andrzej Kozlowski, Zenon Czuba, Jerzy Piecuch
BACKGROUND: It is known that obesity is associated with alterations in blood rheology and venous hemodynamics. Another recent study has confirmed that adipose tissue is actively involved in angiogenesis through secretion of biologically active substances. OBJECTIVE: The aim of this study was to investigate the impact on the venous haemodynamics of the femoral vein on angiogenesis status in morbidly obese patients. METHODS: We studied venous haemodynamics and angiogenesis in a prospective study of obese and non-obese individuals...
May 25, 2018: Clinical Hemorheology and Microcirculation
Laurence Beral, Nathalie Lemonne, Marc Romana, Keyne Charlot, Marie Billaud, Malik Acomat, Coralie Zorobabel, Elie Nader, Maryse Etienne-Julan, Thierry David, Philippe Connes
OBJECTIVE: Our study investigated the prevalence of retinopathy and maculopathy in sickle cell patients and tested the association between these two conditions. In addition, we tested whether hematological and hemorheological parameters, as well as genotype, were involved in the development of these two conditions. METHODS: Seventy sickle cell adult patients were recruited: 37 with sickle cell anemia (SCA) and 33 with sickle cell hemoglobin C disease (SCC). All patients underwent retinal examination and macular ocular coherence tomography...
May 25, 2018: Clinical Hemorheology and Microcirculation
Qiao Wang
OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE...
May 25, 2018: Clinical Hemorheology and Microcirculation
Dane Wildner, Barbara Schellhaas, Daniel Strack, Ruediger S Goertz, Lukas Pfeifer, Cornelia Fießler, Markus F Neurath, Deike Strobel
BACKGROUNDEnhancement patterns on contrast-enhanced ultrasound (CEUS) help to distinguish different liver tumors. OBJECTIVE: Assessing the diagnostic value of dynamic contrast-enhanced ultrasound (DCEUS) for the discrimination of different malignant liver lesions. METHODS: 148 malignant focal liver lesions were assessed prospectively with DCEUS (hepatocellular carcinoma = HCC; cholangiocellular carcinoma = CCC; pancreatic adenocarcinoma = PCA; breast cancer = BC; colorectal cancer = CRC; melanoma = MM)...
May 25, 2018: Clinical Hemorheology and Microcirculation
Mohsen Hamidpour, Davood Bashash, Parisa Nehzati, Mahnaz Abbasalizadeh, Mahin Nikoogoftar, Rafie Hamidpour
INTRODUCTION: The human scavenger receptor class B type 1 (hSR-B1), which serves as a high affinity receptor for HDL, is expressed on platelet surface and mediates various anti-atherogenic functions. Based on the anti-thrombotic effects of HDL and the importance of HDL-SR-B1 in the formation of atherosclerotic plaque, the present study was aimed to investigate and compare the expression level of hSR-B1on platelets of CAD patients with that of normal controls. METHODS: The expressions of the hSR-B1 on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls were detected using flowcytometry and western blotting...
May 25, 2018: Clinical Hemorheology and Microcirculation
Huan Pu, Xue-Li Zhang, Li-Hua Xiang, Jiu-Long Zhang, Guang Xu, Hui Liu, Guang-Yu Tang, Bing-Hui Zhao, Rong Wu
PURPOSE: To evaluate the efficacy of added shear wave elastography (SWE) in breast screening for women with results inconsistent between mammography and conventional ultrasounds (US). MATERIALS AND METHODS: The study consisted of 282 pathologically proven breast lesions. The cancer probability from screening by mammography and conventional US were scored using Breast Imaging Reporting and Data System (BI-RADS). Elastography was used to re-evaluate inconsistent conventional US and mammography results...
May 19, 2018: Clinical Hemorheology and Microcirculation
David N Naumann, Jon Hazeldine, Jon Bishop, Mark J Midwinter, Paul Harrison, Gerard Nash, Sam D Hutchings
BACKGROUND: Preclinical studies report that higher plasma viscosity improves microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical study has tested this hypothesis. OBJECTIVE: We investigated the relationship between plasma viscosity and sublingual microcirculatory flow in patients during resuscitation for traumatic haemorrhagic shock (THS). METHODS: Sublingual video-microscopy was performed for 20 trauma patients with THS as soon as feasible in hospital, and then at 24 h and 48 h...
May 19, 2018: Clinical Hemorheology and Microcirculation
Florian Brettner, Daniel Chappell, Tim Nebelsiek, Daniela Hauer, Gustav Schelling, Bernhard F Becker, Markus Rehm, Florian Weis
BACKGROUND: Patients undergoing cardiac surgery commonly develop systemic inflammation associated with tissue edema, which impairs outcome. One main pathomechanism leading to the edema is the deterioration of the endothelial glycocalyx, a key component of the vascular barrier. In animal models hydrocortisone has proved to be protective for the glycocalyx. OBJECTIVE: This trial evaluates the effect of hydrocortisone on glycocalyx integrity in patients undergoing cardiac surgery with cardiopulmonary bypass...
May 19, 2018: Clinical Hemorheology and Microcirculation
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