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Clinical Hemorheology and Microcirculation

Ismail Hakki Akbudak, Vural Kucukatay, Ozgen Kilic-Erkek, Yasin Ozdemir, Melek Bor-Kucukatay
BACKGROUND: Ozone is used intensively worldwide in treatment and research of various pathologies due to its healing effects. OBJECTIVE: The aim of this study is to investigate the effect of major ozone autohemotherapy on erythrocyte deformability and aggregation. METHODS: 10 and 50μg/ml doses of ozone was applied for 20 minute to venous blood samples obtained from 10 healthy male volunteers. Erythrocyte aggregation, deformability were measured by an ektacytometer...
June 9, 2018: Clinical Hemorheology and Microcirculation
Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Balazs Szabo, Adam Deak, Norbert Nemeth
BACKGROUND: Arteriovenous fistula (AVF) may affect erythrocytes through many pathways (e.g., mechanical, inflammatory). However, these effects haven't been elucidated completely yet. OBJECTIVE: To follow-up the hemorheological and the hematological changes in the presence of artificial carotid-jugular fistula in rats. METHODS: Female Wistar rats were subjected to sham-operated group (SG, n = 6) and to fistula group (FG, n = 10). Under general anesthesia, the right carotid artery and jugular vein were isolated via a neck incision, and in the FG carotid-jugular fistula was performed by microsurgical techniques Hematological variables, red blood cell (RBC) deformability and membrane (mechanical) stability parameters were determined before operation and on the 1st and 6th postoperative weeks...
June 9, 2018: Clinical Hemorheology and Microcirculation
Anna Wärme, Ursula Hadimeri, Henrik Hadimeri, Salmir Nasic, Bernd Stegmayr
BACKGROUND: A native AV-fistula (AVF) for access in hemodialysis (HD) is preferable. Stenosis, a major hurdle, is associated with older age and diabetes mellitus. PURPOSE: This case-control study aimed to clarify if any medical and/or laboratory factors, that can be altered, could be associated to AVF stenosis. METHODS: 33 patients with a patent AVF without need of intervention during a two year period (Controls) were matched by diagnosis and age with 33 patients (Cases), that had at least one radiological invasive examination/intervention due to suspected AVF malfunction (case-control mode 2:1)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Jens Rothenberger
BACKGROUND: Improvement of skin microcirculation would be beneficial in transplanted tissues and thus, there is a demand for effective, reliable and harmless angiogenic treatments. The aim of this study was to assess the effect of capsaicin application (CA), the remote effect of capsaicin application (REC), the impact of remote ischemic conditioning (RIC), and the impact of combined remote ischemic conditioning with capsaicin application (Comb) on human skin microcirculation. METHODS: Perfusion changes were assessed using a laser Doppler device (easyLDI, Aimago Lausanne)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Sebastian Yu, Stephen Chu-Sung Hu, Hsin-Su Yu, Yi-Ying Chin, Yang-Chun Cheng, Chih-Hung Lee
BACKGROUND: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be normal during early stage of microangiopathy in SSc. OBJECTIVE: We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. METHODS: A 67-year-old male came with multiple ulcerations on his fingers for one year...
June 5, 2018: Clinical Hemorheology and Microcirculation
Andrea Bagno
The words "Translational" and "Medicine" have been recently coupled to indicate a combination of disciplines, resources, expertise, and techniques aimed at enhancing prevention, diagnosis, and therapies. As stated in 2015 by the European Society for Translational Medicine, translational medicine is "an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community". By definition, Translational Medicine is a highly interdisciplinary field, which gathers several specialties aimed at improving the global healthcare system...
May 25, 2018: Clinical Hemorheology and Microcirculation
Maciej Wiewiora, Anna Mertas, Alicja Nowowiejska-Wiewiora, Andrzej Kozlowski, Zenon Czuba, Jerzy Piecuch
BACKGROUND: It is known that obesity is associated with alterations in blood rheology and venous hemodynamics. Another recent study has confirmed that adipose tissue is actively involved in angiogenesis through secretion of biologically active substances. OBJECTIVE: The aim of this study was to investigate the impact on the venous haemodynamics of the femoral vein on angiogenesis status in morbidly obese patients. METHODS: We studied venous haemodynamics and angiogenesis in a prospective study of obese and non-obese individuals...
May 25, 2018: Clinical Hemorheology and Microcirculation
Laurence Beral, Nathalie Lemonne, Marc Romana, Keyne Charlot, Marie Billaud, Malik Acomat, Coralie Zorobabel, Elie Nader, Maryse Etienne-Julan, Thierry David, Philippe Connes
OBJECTIVE: Our study investigated the prevalence of retinopathy and maculopathy in sickle cell patients and tested the association between these two conditions. In addition, we tested whether hematological and hemorheological parameters, as well as genotype, were involved in the development of these two conditions. METHODS: Seventy sickle cell adult patients were recruited: 37 with sickle cell anemia (SCA) and 33 with sickle cell hemoglobin C disease (SCC). All patients underwent retinal examination and macular ocular coherence tomography...
May 25, 2018: Clinical Hemorheology and Microcirculation
Qiao Wang
OBJECTIVES: To prospectively evaluate the diagnostic performance of three-dimensional (3D) shear wave elastography (SWE) for breast lesions with quantitative stiffness information from transverse, sagittal and coronal planes. METHODS: Conventional ultrasound (US), two-dimensional (2D)-SWE and 3D-SWE were performed for 122 consecutive patients with 122 breast lesions before biopsy or surgical excision. Maximum elasticity values of Young's modulus (Emax) were recorded on 2D-SWE and three planes of 3D-SWE...
May 25, 2018: Clinical Hemorheology and Microcirculation
Dane Wildner, Barbara Schellhaas, Daniel Strack, Ruediger S Goertz, Lukas Pfeifer, Cornelia Fießler, Markus F Neurath, Deike Strobel
BACKGROUNDEnhancement patterns on contrast-enhanced ultrasound (CEUS) help to distinguish different liver tumors. OBJECTIVE: Assessing the diagnostic value of dynamic contrast-enhanced ultrasound (DCEUS) for the discrimination of different malignant liver lesions. METHODS: 148 malignant focal liver lesions were assessed prospectively with DCEUS (hepatocellular carcinoma = HCC; cholangiocellular carcinoma = CCC; pancreatic adenocarcinoma = PCA; breast cancer = BC; colorectal cancer = CRC; melanoma = MM)...
May 25, 2018: Clinical Hemorheology and Microcirculation
Mohsen Hamidpour, Davood Bashash, Parisa Nehzati, Mahnaz Abbasalizadeh, Mahin Nikoogoftar, Rafie Hamidpour
INTRODUCTION: The human scavenger receptor class B type 1 (hSR-B1), which serves as a high affinity receptor for HDL, is expressed on platelet surface and mediates various anti-atherogenic functions. Based on the anti-thrombotic effects of HDL and the importance of HDL-SR-B1 in the formation of atherosclerotic plaque, the present study was aimed to investigate and compare the expression level of hSR-B1on platelets of CAD patients with that of normal controls. METHODS: The expressions of the hSR-B1 on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls were detected using flowcytometry and western blotting...
May 25, 2018: Clinical Hemorheology and Microcirculation
Huan Pu, Xue-Li Zhang, Li-Hua Xiang, Jiu-Long Zhang, Guang Xu, Hui Liu, Guang-Yu Tang, Bing-Hui Zhao, Rong Wu
PURPOSE: To evaluate the efficacy of added shear wave elastography (SWE) in breast screening for women with results inconsistent between mammography and conventional ultrasounds (US). MATERIALS AND METHODS: The study consisted of 282 pathologically proven breast lesions. The cancer probability from screening by mammography and conventional US were scored using Breast Imaging Reporting and Data System (BI-RADS). Elastography was used to re-evaluate inconsistent conventional US and mammography results...
May 19, 2018: Clinical Hemorheology and Microcirculation
David N Naumann, Jon Hazeldine, Jon Bishop, Mark J Midwinter, Paul Harrison, Gerard Nash, Sam D Hutchings
BACKGROUND: Preclinical studies report that higher plasma viscosity improves microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical study has tested this hypothesis. OBJECTIVE: We investigated the relationship between plasma viscosity and sublingual microcirculatory flow in patients during resuscitation for traumatic haemorrhagic shock (THS). METHODS: Sublingual video-microscopy was performed for 20 trauma patients with THS as soon as feasible in hospital, and then at 24 h and 48 h...
May 19, 2018: Clinical Hemorheology and Microcirculation
Florian Brettner, Daniel Chappell, Tim Nebelsiek, Daniela Hauer, Gustav Schelling, Bernhard F Becker, Markus Rehm, Florian Weis
BACKGROUND: Patients undergoing cardiac surgery commonly develop systemic inflammation associated with tissue edema, which impairs outcome. One main pathomechanism leading to the edema is the deterioration of the endothelial glycocalyx, a key component of the vascular barrier. In animal models hydrocortisone has proved to be protective for the glycocalyx. OBJECTIVE: This trial evaluates the effect of hydrocortisone on glycocalyx integrity in patients undergoing cardiac surgery with cardiopulmonary bypass...
May 19, 2018: Clinical Hemorheology and Microcirculation
Jing Wan, Rong Wu, Minghua Yao, Guang Xu, Hui Liu, Huan Pu, Lihua Xiang, Shupin Zhang
PURPOSE: To assess the elastographic features of triple-negative breast cancers and evaluate the diagnostic value of acoustic radiation force impulse imaging (ARFI) for the characterization of triple-negative breast cancers. MATERIALS AND METHODS: This study analyzed data from 234 women with breast cancer. Patients were categorized into three groups; 1) triple-negative breast cancers (n = 48); 2) ER-positive tumors (n = 128) and 3) HER2-positive tumors (n = 58)...
May 19, 2018: Clinical Hemorheology and Microcirculation
Romeo Martini, Andrea Bagno
The wavelet analysis has been applied to the Laser Doppler Fluxmetry for assessing the frequency spectrum of the flowmotion to study the microvascular function waves.Although the application of wavelet analysis has allowed a detailed evaluation of the microvascular function, its use does not seem to be yet widespread over the last two decades.Aiming to improve the diffusion of this methodology, we herein present a systematic review of the literature about the application of the wavelet analysis to the laser Doppler fluxmetry signal...
April 14, 2018: Clinical Hemorheology and Microcirculation
E Pretorius
OBJECTIVE: This review focusses on the erythrocytes (RBCs) and their structural changes during inflammation and impaired blood rheology. We discuss systemic inflammation and the effects of dysregulated inflammatory molecules. These pro-inflammatory molecules directly affect the haematological system, and particularly the RBCs, platelets and plasma proteins. We focus on the three main changes; increased RBC eryptosis (programmed cell death, similar to apoptosis) and pathological deformability, platelet hyperreactivity and anomalous blood clotting, due to pathological changes to fibrin(ogen) protein structure...
April 14, 2018: Clinical Hemorheology and Microcirculation
Ursula Windberger, Roland Auer, Roberto Plasenzotti, Stephanie Eloff, Julian A Skidmore
No abstract text is available yet for this article.
April 14, 2018: Clinical Hemorheology and Microcirculation
Christoph Dibiasi, Jacek Plewka, Leon Ploszczanski, Veronika Glanz, Helga Lichtenegger, Ursula Windberger
BACKGROUND: Although the coagulation system is evolutionary well preserved, profound species differences exist in viscoelastic as well as in common laboratory tests of coagulation. OBJECTIVE: Evaluating differences in clot formation and material characterisation of clots of four mammalian species on macro-, micro- and nanoscales by the means of rheometry, scanning electron microscopy (SEM) and small angle x-ray scattering (SAXS). METHODS: Blood samples were collected from healthy human volunteers, laboratory rats (HL/LE inbred strain), warmblood horses and dromedary camels...
April 14, 2018: Clinical Hemorheology and Microcirculation
Fabian Tomschi, Daniel Bizjak, Wilhelm Bloch, Joachim Latsch, Hans Georg Predel, Marijke Grau
BACKGROUND: Red blood cell (RBC) deformability and blood viscosity are essential to ensure optimal microcirculation and may contribute to athletic performance. OBJECTIVE: To investigate the acute responses of density fractionated young, middle old and old RBC, RBC viscosity (RBCV), plasma viscosity (PV) and hematological changes to two running modes (intensive and moderate). METHODS: 27 young and healthy men of different training status participated in this study and were grouped into three groups in accordance to their VO2peak and conducted an intensive and moderate running test, respectively (crossover design)...
April 14, 2018: Clinical Hemorheology and Microcirculation
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