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Clinical Hemorheology and Microcirculation

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https://www.readbyqxmd.com/read/27983547/factors-associated-with-initial-incomplete-ablation-for-benign-thyroid-nodules-after-radiofrequency-ablation-first-results-of-ceus-evaluation
#1
Chong-Ke Zhao, Hui-Xiong Xu, Feng Lu, Li-Ping Sun, Ya-Ping He, Le-Hang Guo, Xiao-Long Li, Xiao-Wan Bo, Wen-Wen Yue
OBJECTIVE: To assess the factors associated with initial incomplete ablation (ICA) after radiofrequency ablation for benign thyroid nodules (BTNs). MATERIALS AND METHODS: 69 BTNs (mean volume 6.35±5.66 ml, range 1.00-25.04 ml) confirmed by fine-needle aspiration cytology (FNAC) in fifty-four patients were treated with ultrasound-guided percutaneous radiofrequency ablation (RFA) and the local treatment efficacy was immediately assessed by intra-procedural contrast-enhanced ultrasound (CEUS)...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983546/the-measurement-of-cutaneous-blood-flow-in-healthy-volunteers-subjected-to-physical-exercise-with-ultrasound-doppler-imaging-and-laser-doppler-flowmetry
#2
Helena Lenasi, Nejka Potočnik, Nikolaj Petrishchev, Marina Papp, Anastasia Egorkina, Marina Girina, Marina Skedina, Anna Kovaleva
We evaluated blood flow parameters in the cutaneous with the help of high-frequency ultrasound Doppler flowmetry (UDF) and laser Doppler fluxmetry (LDF) after submaximal physical exercises on cycloergometer. During investigation by means of UDF medium linear speed of blood flow was estimated in absolute values (Vam) in cm/s. The level of perfusion in the volume of tissue in a unit of time was registered in perfusion units (PU) with the help of LDF. Comparison of values of Vam and PU was made every 20 s during recovery period of every patient...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983545/comparison-of-the-simple-red-blood-cell-adhesiveness-aggregation-test-with-the-laser-assisted-optical-rotational-cell-analyzer-red-blood-cell-aggregation-in-patients-with-coronary-artery-disease-and-a-healthy-control-group
#3
Heike Preibsch, Stefanie Keymel, Malte Kelm, Theodor Baars, Petra Kleinbongard
BACKGROUND: Red blood cell (RBC) aggregation influences blood flow properties, impacts blood microcirculation and consequently oxygen delivery. Different methods are established to determine RBC aggregation: under static conditions (i.e. the RBC adhesiveness/aggregation test (EAAT)) or under shear conditions (i.e. the laser-assisted optical rotational cell analyzer (LORCA)). OBJECTIVE: Comparison of these two different methods in detecting the RBC aggregation of patients with coronary artery disease (CAD) and of healthy controls...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983544/first-experience-of-comparisons-between-two-different-shear-wave-speed-imaging-systems-in-differentiating-malignant-from-benign-thyroid-nodules
#4
Ya-Ping He, Hui-Xiong Xu, Dan Wang, Xiao-Long Li, Wei-Wei Ren, Chong-Ke Zhao, Xiao-Wan Bo, Bo-Ji Liu, Wen-Wen Yue
OBJECTIVE: The purpose of this study was to comparatively evaluate the two different shear wave speed (SWS) imaging systems of Toshiba shear wave elastography (T-SWE) and SuperSonic SWE (S-SWE) in distinguishing malignant from benign thyroid nodules (TNs). MATERIALS AND METHODS: 140 patients with 140 focal TNs were enrolled and underwent T-SWE and S-SWE before fine-needle aspiration (FNA) biopsy or surgery. SWE indices of mean, standard deviation and maximum values (E-mean, E-SD and E-max) of elastic modulus in TNs were measured on a color-coded mapping...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983543/deep-tissue-near-infrared-second-derivative-spectrophotometry-for-the-assessment-of-claudication-in-peripheral-arterial-disease
#5
Aristotle G Koutsiaris
AIM: The purpose of this study was the application of a second derivative near infrared spectrophotometric (NIRS) technique to the human calf muscle in order to see if peripheral arterial disease (PAD) patients can be discriminated from control subjects, before, during and after a standard treadmill exercise test. METHODS: Three groups of human subjects were studied: group A consisted of 10 control subjects and groups B and C were formed by PAD patients classified as Fontaine's stage 2a (5 patients) and 2b (10 patients), respectively...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983542/pentoxifylline-attenuates-the-local-and%C3%A2-systemic-inflammatory-response-after%C3%A2-infrarenal-abdominal-aortic-ischemia-reperfusion
#6
Tibor Nagy, Péter Hardi, Ildikó Takács, Mónika Tóth, Laura Petrovics, Gábor Jancsó, László Sínay, Gábor Fazekas, Örs Pintér, Endre Arató
AIMS: We studied the new anti-inflammatory effects of non-specific phosphodiesterase (PDE) inhibitor pentoxifylline (PTX) on ischaemia-reperfusion injury and postconditioning of the lower extremities. We aimed to examine the oxidative stress parameters (OSP), the inflammatory response and the changes in structure of skeletal muscle after revascularization surgery. METHODS: 50 Wistar rats in five groups underwent a 60 min infrarenal aortic cross clamping. After the ischaemia in IR+PC group ischemic postconditioning was performed, intermittent 15 seconds reperfusion, 15 seconds ischaemic periods were applied four times...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983541/effect-of-increasing-mean-arterial-blood-pressure-on-microcirculation-in-patients-with-cardiogenic-shock-supported-by-extracorporeal-membrane-oxygenation
#7
Zhongtao Du, Zaishen Jia, Jinhong Wang, Zhichen Xing, Chunjing Jiang, Bo Xu, Xiaofang Yang, Feng Yang, Na Miao, Jialin Xing, Hong Wang, Ming Jia, Xiaotong Hou
BACKGROUND: Little is known about the effect of mean arterial blood pressure (MAP) augmentation on the microcirculation in cardiogenic-shock patients with peripheral veno-arterial extracorporeal membrane oxygenation (ECMO) support. We investigated the effect of increasing MAP on the microcirculation in cardiogenic-shock patients with ECMO support. METHODS: A single-center prospective observational study under taken in ICU patients undergoing ECMO support for post-cardiotomy cardiogenic shock was carried out...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27983540/plasma-nitric-oxide-level-is-correlated-with-microvascular-functions-in-the-peripheral-arterial-disease
#8
Muzaffer Akkoca, Suzan Emel Usanmaz, Cuneyt Koksoy, Ugur Bengisun, Emine Demirel-Yilmaz
At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising a control group of healthy individuals, and patients with PAD caused by either atherosclerosis or Buerger's disease. Microvascular perfusion was examined using laser Doppler imaging of cutaneous erythrocyte flux after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP)...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935553/percutaneous-irreversible-electroporation-ire-of-prostate-cancer-contrast-enhanced-ultrasound-ceus-findings-during-follow%C3%A2-up
#9
L P Beyer, B Pregler, C Nießen, K Michalik, M Haimerl, C Stroszczynski, E M Jung, P Wiggermann
PURPOSE: Irreversible electroporation (IRE) is a focal non-thermal ablation technique that can be used to treat prostate cancer (Pca). The objective was to document the evolution of the volume of the prostate gland and the ablation zone after IRE of Pca. MATERIAL AND METHODS: A retrospective analysis of the image findings of CEUS 1 day, 6 weeks, 3 months and 6 months after IRE of 25 patients was conducted. The prostate gland volumes and the size of the ablation zones were documented...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935552/prefabrication-and-free-transfer-of-a-tissue-engineered-composite-flap-an-experimental-model-in-the-rat
#10
V Mandlik, A Kehrer, L Jiga, B Hoinoiu, M Ionac, F Jung, R Staudenmaier, L Prantl
BACKGROUND: The technique of flap-prefabrication has been successfully established in tissue engineering: missing intrinsic vascularisation of engineered tissue can be generated in vivo by microsurgical vesselloop construction. It is possible to move engineered tissue into a defect with microsurgery. In the literature, the combination of engineered tissue covered with skin is not widely reported. OBJECTIVE: Aim of this study was to establish a model to investigate scaffold prefabrication with full thickness skin graft coverage with subsequent free tissue transfer...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935551/organotypic-soft-tissue-co-cultures-morphological-changes-in-microvascular-endothelial-tubes-after-incubation-with%C3%A2-iodinated-contrast-media
#11
S Kaessmeyer, J Sehl, M Khiao In, B Hiebl, R Merle, F Jung, R P Franke, J Plendl
INTRODUCTION: Clinical complications like thrombosis or anaphylaxis have been described to go along with the intra-venous or intra-arterial injection of iodinated contrast media (CM). It has been suggested that the administration of CM affects rheological parameters and thereby causes reduced blood velocity in microvessels. In vitro studies revealed significant buckling of endothelial cells after exposure to CM reducing the lumen of vessels. The aim of this study was to test the influence of CM on three-dimensional microvascular tubules with open lumina within an organotypic soft-tissue co-culture assay in vitro...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935550/vascular-complications-in-liver-transplantation-beneficial-role-of%C3%A2-contrast-enhanced-ultrasound-ceus-%C3%A2-in%C3%A2-the%C3%A2-postoperative-phase
#12
J Rübenthaler, K J Paprottka, E Hameister, K Hoffmann, N Joiko, M Reiser, D A Clevert
PURPOSE: To compare the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) in the diagnosis of vascular complications after liver transplantation in the postoperative phase. MATERIALS AND METHODS: A total of 60 patients with elevated liver function tests after liver transplantation with initial imaging studies between July 2005 and November 2015 were retrospectively analysed. CEUS and CT were compared in their diagnosis of vascular complications and CT was considered as the gold standard...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935549/malignancies-after-liver-transplantation-value-of-contrast-enhanced-ultrasound-ceus
#13
J Rübenthaler, K J Paprottka, E Hameister, K Hoffmann, N Joiko, M Reiser, D A Clevert
PURPOSE: To evaluate the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) in the diagnosis of malignancies after liver transplantation. MATERIALS AND METHODS: A total of 23 patients with suspicious liver masses after liver transplantation with initial imaging series between September 2006 and September 2015 were statistically analysed. CEUS and CT were compared in their diagnosis of malignancy with CT being the gold standard...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935548/microwave-ablations-of-large-hcc-lesions-added-value-of-ceus-examinations-for%C3%A2-ablation-success-control
#14
B Pregler, L P Beyer, I Wiesinger, C Nießen, E M Jung, C Stroszczynski, P Wiggermann
PURPOSE: To assess the value of dynamic contrast enhanced ultrasound (CEUS) for the detection of residual tumor tissue day 1 after microwave ablation (MWA) of large hepatocellular carcinoma (HCC) compared to MRI. MATERIAL AND METHODS: 30 consecutive patients (5 females, 25 males, mean age 64 years, age range 54-73 years) with an untreated HCC lesion larger than or equal to 3 cm underwent percutaneous MWA between 03/2014 and 04/2016. 1 patient was excluded because of an artificial pacemaker...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935547/flap-design-and-perfusion-are-keys-of%C3%A2-success-axial-fasciocutaneous-posterior-thigh-flaps-for-deep-small-pelvic-defect-reconstruction
#15
Andreas Kehrer, Philipp Lamby, Benjamin H Miranda, Lukas Prantl, Juergen H Dolderer
BACKGROUND AND OBJECTIVES: Radical excisions of the rectum often result in large perineal and intrapelvic defects. Compromised wound healing can delay adjuvant therapies and limit the patient's prognosis. With current treatment, integrity of the abdominal wall may be maintained. The defect geometry is unique and requires extensive volume for reconstruction. This study describes the surgical technique and reports clinical outcomes of fasciocutaneous posterior thigh flaps as preliminary data for this indication...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935546/shear-wave-elastography-of-the-testes-in%C3%A2-a%C3%A2-healthy-study-collective-differences-in%C3%A2-standard-values-between-arfi-and%C3%A2-vtiq%C3%A2-techniques
#16
J Marcon, M Trottmann, J Rübenthaler, C G Stief, M F Reiser, D A Clevert
INTRODUCTION: Shear wave elastography (SWE) is a recent technique in the assessment of tissue elasticity. Different elastography techniques have been described over the years.Acoustic Radiation Force Impulse Imaging (ARFI) uses mechanical excitation of tissue to create detectable shear waves, a higher shear wave velocity being associated with an increased tissue stiffness.The Virtual Touch Tissue Imaging Quantification (VTIQ) method uses a mechanical push pulse as well, additionally creating a colour-coded map, in which tissue stiffness can be measured on the stored map on the ultrasound device after measurement...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27935545/effects-of-different-components-of-the-extracellular-matrix-on-endothelialization
#17
A Krüger-Genge, R Fuhrmann, F Jung, R P Franke
The endothelialisation of cardiovascular prostheses is known to improve their haemocompatibility. As such body-foreign materials often do not endothelialize spontaneously. A lot of in vitro studies are ongoing how endothelialisation of biomaterials can be improved. In this study the influence of different components of a tissue-typical extracellular matrix (ECM) like laminin, fibronectin or gelatin on the formation of an endothelial cell monolayer and on the shear resistance of adherent cells on these substrates was studied...
December 8, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886006/semi-automated-extraction-and-characterization-of-stromal-vascular-fraction-using-a-new-medical-device
#18
Alexander Hanke, Lukas Prantl, Carina Wenzel, Michael Nerlich, Gero Brockhoff, Markus Loibl, Sebastian Gehmert
INTRODUCTION: The stem cell rich Stromal Vascular Fraction (SVF) can be harvested by processing lipo-aspirate or fat tissue with an enzymatic digestion followed by centrifugation. To date neither a standardised extraction method for SVF nor a generally admitted protocol for cell application in patients exists. A novel commercially available semi-automated device for the extraction of SVF promises sterility, consistent results and usability in the clinical routine. The aim of this work was to compare the quantity and quality of the SVF between the new system and an established manual laboratory method...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886005/compression-in-the-treatment-of-chronic-venous-insufficiency-efficacy-depending-on-the-length-of-the-stocking
#19
Wolfgang Konschake, Helene Riebe, P Pediaditi, Hermann Haase, Michael Jünger, Stine Lutze
BACKGROUND: Below knee two-component compression stockings (AD) have revealed as effective for compression treatment of venous leg ulcers. Upto groin, thigh length stocking (AG) may enhance clinical effects, however wear comfort of these stocking may be affected. OBJECTIVE: venous haemodynamic in relation to the length of compression stockings. METHODS: A two-component AD stocking (37 mmHg) and two thigh length stockings (AG 37, with an interface pressure of 37 mmHg; AG 45, with an interface pressure of 45 mmHg) were tested by 16 patients with CVI...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886004/influence-of-surface-roughness-on-neural-differentiation-of-human-induced-pluripotent-stem-cells
#20
Zhengdong Li, Weiwei Wang, Karl Kratz, Judit Küchler, Xun Xu, Jie Zou, Deng Zijun, Xianlei Sun, Manfred Gossen, Nan Ma, Andreas Lendlein
Induced pluripotent stem cells (iPSCs) own the capacity to develop into all cell types of the adult body, presenting high potential in regenerative medicine. Regulating and controlling the differentiation of iPSCs using the surface topographic cues of biomaterials is a promising and safe approach to enhance their therapeutic efficacy. In this study, we tested the effects of surface roughness on differentiation of human iPSCs into neural progenitor cells and dopaminergic neuron cells using polystyrene with different roughness (R0: flat surface; R1: rough surface, Rq ∼ 6 μm; R2: rough surface, Rq ∼ 38 μm)...
November 23, 2016: Clinical Hemorheology and Microcirculation
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