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Clinical Hemorheology and Microcirculation

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https://www.readbyqxmd.com/read/27886006/semi-automated-extraction-and-characterization-of-stromal-vascular-fraction-using-a-new-medical-device
#1
Alexander Hanke, Lukas Prantl, Carina Wenzel, Michael Nerlich, Gero Brockhoff, Markus Loibl, Sebastian Gehmert
INTRODUCTION: The stem cell rich Stromal Vascular Fraction (SVF) can be harvested by processing lipo-aspirate or fat tissue with an enzymatic digestion followed by centrifugation. To date neither a standardised extraction method for SVF nor a generally admitted protocol for cell application in patients exists. A novel commercially available semi-automated device for the extraction of SVF promises sterility, consistent results and usability in the clinical routine. The aim of this work was to compare the quantity and quality of the SVF between the new system and an established manual laboratory method...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886005/compression-in-the-treatment-of-chronic-venous-insufficiency-efficacy-depending-on-the-length-of-the-stocking
#2
Wolfgang Konschake, Helene Riebe, P Pediaditi, Hermann Haase, Michael Jünger, Stine Lutze
BACKGROUND: Below knee two-component compression stockings (AD) have revealed as effective for compression treatment of venous leg ulcers. Upto groin, thigh length stocking (AG) may enhance clinical effects, however wear comfort of these stocking may be affected. OBJECTIVE: venous haemodynamic in relation to the length of compression stockings. METHODS: A two-component AD stocking (37 mmHg) and two thigh length stockings (AG 37, with an interface pressure of 37 mmHg; AG 45, with an interface pressure of 45 mmHg) were tested by 16 patients with CVI...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886004/influence-of-surface-roughness-on-neural-differentiation-of-human-induced-pluripotent-stem-cells
#3
Zhengdong Li, Weiwei Wang, Karl Kratz, Judit Küchler, Xun Xu, Jie Zou, Deng Zijun, Xianlei Sun, Manfred Gossen, Nan Ma, Andreas Lendlein
Induced pluripotent stem cells (iPSCs) own the capacity to develop into all cell types of the adult body, presenting high potential in regenerative medicine. Regulating and controlling the differentiation of iPSCs using the surface topographic cues of biomaterials is a promising and safe approach to enhance their therapeutic efficacy. In this study, we tested the effects of surface roughness on differentiation of human iPSCs into neural progenitor cells and dopaminergic neuron cells using polystyrene with different roughness (R0: flat surface; R1: rough surface, Rq ∼ 6 μm; R2: rough surface, Rq ∼ 38 μm)...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886003/mri-and-contrast-enhanced-ultrasound-ceus-image-fusion-of-renal-cysts
#4
J Rübenthaler, K J Paprottka, J Marcon, M Reiser, D A Clevert
Ultrasound is a common and established imaging method for the initial characterization of renal lesions. The widespread used Bosniak classification (I-IV) classifies renal lesions in five individual groups using contrast-enhanced computer tomography (CE-CT), magnetic resonance imaging (MRI) and/or contrast-enhanced ultrasound (CEUS) imaging criteria. For complex pathologies, CEUS/MRI image fusion is a novel imaging technique for the differentiation of benign and malignant renal lesions. Compared to CE-CT and MRI alone, ultrasound image fusion offers the additional possibility of being a real-time imaging technique that can be used together with other cross-sectional imaging techniques...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886002/three-dimensional-vs-two-dimensional-shear-wave-elastography-of-the-testes-preliminary-study-on-a-healthy-collective
#5
J Marcon, M Trottmann, J Rübenthaler, M D'Anastasi, C G Stief, M F Reiser, D A Clevert
INTRODUCTION: Shear wave elastography (SWE) and its derivative Supersonic Shear Imaging (SSI) are newer techniques for the determination of tissue elasticity by measuring the velocity of generated shear waves (SWV), which correlates positively with tissue stiffness.The techniques are integrated into many modern ultrasound systems and have been examined in the evaluation of viscoelastic properties of different organ systems. Two-dimensional shear wave elastography (2D SWE) of the testes has been found to be a useful tool in recent studies which included the determination of standard values in healthy volunteers...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27886001/strategy-for-the-hemocompatibility-testing-of-microparticles
#6
S Braune, S Basu, K Kratz, J Bäckemo Johansson, M Reinthaler, A Lendlein, F Jung
Polymer-based microparticles are applied as non-thrombogenic or thrombogenic materials in a wide variety of intra- or extra-corporeal medical devices. As demanded by the regulatory agencies, the hemocompatibility of these blood contacting biomaterials has to be evaluated in vitro to ensure that the particle systems appropriately fulfill the envisioned function without causing undesired events such as thrombosis or inflammation. Currently described in vitro assays for hemocompatibility testing of particles comprise tests with different single cell types (e...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858704/comparison-of-bipolar-radiofrequency-ablation-zones-in-an-in-vivo-porcine-model-correlation-of-histology-and-gross-pathological-findings
#7
Ole Gemeinhardt, Franz G M Poch, Bernhard Hiebl, Urte Kunz-Zurbuchen, Giuliano M Corte, Stefan F Thieme, Janis L Vahldiek, Stefan M Niehues, Martin E Kreis, Robert Klopfleisch, Kai S Lehmann
BACKGROUND: Continuing research ex vivo and in vivo with animal models is performed to advance the oncological safety of radiofrequency ablation (RFA) of liver tumors. In these experiments, frequently imaging modalities (e.g. MRI or CT) or macro-morphological measurements are used to determine the full extent of the different ablation zones inside of RFA lesions. However, no systematic study has been performed so far, which verified the accuracy of the macro-morphological findings. Therefore, the present study aimed to correlate histological and gross pathological findings of bipolar radiofrequency ablation zones of pig livers with regard to cell viability in vivo...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858703/chronic-liver-disease-quantitative-mri-vs%C3%A2-ceus-based-microperfusion
#8
M Haimerl, S Poelsterl, L P Beyer, I Wiesinger, C Nießen, C Stroszczynski, P Wiggermann, E-M Jung
PURPOSE: To compare the diagnostic performance of MRI-based T1 relaxometry with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation for evaluation of liver function. MATERIALS AND METHODS: 22 patients underwent Gd-EOB-DTPA-enhanced MRI with T1 relaxometry and previous or consecutive CEUS examinations. A transverse 3D VIBE sequence with an inline T1 calculation was acquired and the reduction rate of T1 relaxation time (rrT1) was evaluated. For CEUS measurements (1-6 MHz), a bolus injection of 1...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858702/both-flow-mediated-dilation-and%C3%A2-constriction-are-associated-with%C3%A2-changes-in%C3%A2-blood-flow-and-shear-stress-%C3%A2-two%C3%A2-complementary-perspectives-on%C3%A2-endothelial-function
#9
Tommaso Gori, Urs von Henning, Selina Muxel, Sarina Schaefer, Federica Fasola, Marcus Vosseler, Boris Schnorbus, Harald Binder, John D Parker, Thomas Münzel
INTRODUCTION: Flow-mediated dilation (FMD) quantifies endothelium-dependent vasomotor responses to short-term increases in blood flow. Low-flow mediated vasoconstriction (L-FMC) has been more recently introduced as additional measure of endothelial function, and its relationship with changes in blood flow, cardiovascular risk factors and FMD ha∧s been less well characterized. MATERIALS AND METHODS: We evaluated radial artery FMD and L-FMC along with the changes in blood flow and shear rate/stress in 584 patients with known or suspected coronary artery disease (72...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858701/contrast-enhanced-ultrasonography-as-a-new-method-for-assessing-autonomization-of-pedicle-and-microvascular-free-flaps-in-head-and-neck-reconstructive-surgery
#10
Steffen Mueller, Christina M Wendl, Tobias Ettl, Christoph Klingelhöffer, Sebastian Geis, Lukas Prantl, Torsten E Reichert, Ernst Michael Jung
OBJECTIVE: Evaluating vascular autonomization of pedicle and microvascular free flaps for soft tissue reconstruction in the head and neck area by means of postoperative quantitative measurement of dynamic contrast values obtained with contrast-enhanced ultrasound. METHODS: 8/18 patients underwent lip reconstruction with a pedicle flap, 10 patients reconstruction of other parts of the head with a microvascular free transplant. Ultrasound examinations were within the 1st postoperative week and 4 weeks after surgery...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814293/erythrocyte-nitric-oxide-in-glaucoma-patients-ex-vivo-study
#11
Rita Esteves, Teresa Freitas, Pedro Teixeira, Patrícia Napoleão, Carlos Neves, Carlota Saldanha
BACKGROUND: Glaucoma is an optic neuropathy associated with vascular dysregulation and increased intra-ocular pressure (IOP). Timolol is used as treatment for reducing IOP, by limiting aqueous humour production. Increased NOS expression as well as decreased levels of nitric oxide (NO) metabolites, and high activity of erythrocyte acetylcholinesterase (AChE) were observed in primary open angle glaucoma patients. OBJECTIVE: This ex vivo study aims to evaluate timolol effect in NO efflux and its derivatives in glaucoma patient's erythrocytes...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814292/hemorheological-alterations-in-sickle-cell-anemia-and-their-clinical-consequences-the-role-of-genetic-modulators
#12
Marisa Silva, Sofia Vargas, Andreia Coelho, Alexandra Dias, Teresa Ferreira, Anabela Morais, Raquel Maia, Paula Kjöllerström, João Lavinha, Paula Faustino
Sickle cell anemia (SCA) is an autosomal recessive disease caused by the HBB:c.20A>T mutation that leads to hemoglobin S synthesis. The disease presents with high clinical heterogeneity characterized by chronic hemolysis, recurrent episodes of vaso-oclusion and infection. This work aimed to characterize by in silico studies some genetic modulators of severe hemolysis and stroke risk in children with SCA, and understand their consequences at the hemorheological level.Association studies were performed between hemolysis biomarkers as well as the degree of cerebral vasculopathy and the inheritance of several polymorphic regions in genes related with vascular cell adhesion and vascular tonus in pediatric SCA patients...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814291/vascular-dysfunction-associated-with-alzheimer-s-disease
#13
Cristiana Carelli-Alinovi, Simone Dinarelli, Marco Girasole, Francesco Misiti
Our attention is focused on the study of a new model based on the red blood cell (RBC) and on its interaction with amyloid beta peptide 1-42 (Aβ). RBC are highly deformable to assist blood flow in the microcirculation. For this reasons RBC abnormalities could contribute to Alzheimer's disease (AD) by obstructing oxygen delivery to brain, causing hypoxia. In our work, considering that RBC membrane contains, among blood elements, higher acetylcholinesterase (AChE) levels, we can assume that in blood occurs a mechanism similar to the one which occurs at the neuronal level leading to an increase of Aβ toxicity mediated by its binding with AChE, located on the RBC external face...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814290/influence-of-nanoporous-poly-ether-imide-particle-extracts-on-human-aortic-endothelial-cells-haecs
#14
Reddi K Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl Kratz, Andreas Lendlein, Sarada D Tetali
Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by convention techniques like hemodialysis is due to their strong covalent albumin binding (greater than 95%) and hydrophobic nature, which led to alternatives like usage of hydrophobic adsorber's in removing these toxins from the plasma of kidney patients...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814289/feasability-of-contrast-enhanced-ultrasound-with-image-fusion-of-ceus-and-ms-ct-for%C3%A2-endovascular-grafting-in-infrarenal-abdominal-aortic-aneurysm-in-a%C3%A2-single-patient
#15
H Zimmermann, J Rübenthaler, P Paprottka, K J Paprottka, M Reiser, D A Clevert
Currently methods to reduce radiation and contrast media application in endovascular repair of aortic aneurysms (EVAR) are investigated. First positive results for real-time contrast medium-enhanced ultrasonography (CEUS) guided endovascular aortic repair have been reported. A combination with image fusion of CEUS and preoperative multi-slice computed tomography (MS-CT) might offer added safety regarding stent-graft positioning and sealing of the landing zones.EVAR was performed in a patient with an asymptomatic infrarenal aortic aneurysm and a penetrating aortic ulcer in the neck region...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814288/evidence-based-hemorheology-does%C3%A2-it%C3%A2-exist-%C3%A2-applying-evidence-from%C3%A2-clinical-studies-to-the-individual-patient
#16
António Vaz Carneiro
Clinicians are used to treat individual patients, and therefore may feel that clinical trials and systematic reviews do not give information for optimal treatment of the single patient.Evidence Based Medicine (EBM) is the integration of research evidence (from clinically relevant studies conducted using sound methodology) with clinical expertise (clinician's cumulated experience) and patient values (personal preferences and unique concerns and expectations).The practical steps of EBM include: 1) assess the patient, 2) ask the clinical question, 3) acquire the evidence, 4) critically appraise the evidence, 5) apply the results to the patient and 6) self-evaluate one's practice...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814287/a-primary-hepatic-angiosarcoma-mimicking-intrahepatic-cholangiocarcinoma-on%C3%A2-conventional-ultrasound-and-contrast-enhanced-ultrasound-a%C3%A2-case-report-and%C3%A2-review-of-literatures
#17
Hui-Xiong Xu, Chong-Ke Zhao, Le-Hang Guo, Li-Ping Sun
Primary hepatic angiosarcoma (PHA) is a rare malignancy with a badly poor prognosis. The extremely low morbidity and untypical clinical manifestations conduce to a missed diagnosis. The present study reported a case of an adult male patient who was pathologically confirmed to be PHA, which mimicked intrahepatic cholangiocarcinoma on conventional ultrasound and contrast-enhanced ultrasound. Findings on various imaging examinations were carefully evaluated and the associated literatures were also reviewed...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814286/microcirculation-and-blood-rheology-abnormalities-in-chronic-heart-failure
#18
Irina Tikhomirova, Elena Petrochenko, Alexei Muravyov, Yulia Malysheva, Alexandr Petrochenko, Vladimir Yakusevich, Anna Oslyakova
No abstract text is available yet for this article.
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814285/swirling-of-microbubbles-demonstration-of-a-new-finding-of-carotid-plaque-ulceration-on-contrast-enhanced-ultrasound-explaining-the-arterio-arterial-embolism-mechanism
#19
Vasileios Rafailidis, Afroditi Charitanti, Thomas Tegos, Dimitrios Rafailidis, Ioannis Chryssogonidis
Carotid plaque ulceration is a well-established feature of vulnerability, associated with high risk for neurological symptoms. From a pathogenetic point of view, the mechanism responsible for occurrence of symptomatology relies on the aggregation of platelets within the ulcer cavity, activation of coagulation mechanism, formation of thrombus and arterio-arterial embolization of thrombotic material in the central nervous system. Many imaging modalities including unenhanced ultrasound, computed tomographic angiography and magnetic resonance angiography have been used to image and diagnose carotid plaque ulceration with varying success...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814284/comparison-of-virtual-touch-tissue-quantification-and-virtual-touch-tissue-imaging-quantification-for-diagnosis-of-solid-breast-tumors-of-different-sizes
#20
Rong Wu, Ying-Pei Chen, Ting Han, Ming-Hua Yao, Guang Xu, Li-Xia Zhao, Hui Liu, Huan Pu, Yan Fang
BACKGROUND: Acoustic radiation force impulse imaging (ARFI) with Virtual Touch Tissue Quantification (VTQ) or Virtual Touch Tissue Imaging Quantification (VTIQ) measures shear wave velocity (SWV), which is proportional to tissue stiffness, a diagnostic parameter for malignancy. OBJECTIVE: To compare the performance of VTQ and VTIQ in diagnosing solid breast tumors. METHODS: Conventional ultrasound, VTQ and VTIQ were used to examine 246 solid breast tumors from 230 patients...
November 4, 2016: Clinical Hemorheology and Microcirculation
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