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Oral Oncology

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https://www.readbyqxmd.com/read/27894848/oral-extramedullary-plasmacytoma-in-a-hiv-positive-patient
#1
LETTER
Premalatha Shetty, Flora D Lobo, R Arvind, Sameep S Shetty
No abstract text is available yet for this article.
November 25, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27818058/immunotherapy-in-head-and-neck-cancer-need-for-a-new-strategy-rapid-progression-with-nivolumab-then-unexpected-response-with-next-treatment
#2
LETTER
Amaury Daste, Erwan de Mones, Laurence Digue, Louis François, Charlotte Domblides, Charles Dupin, Antoine Bigourdan, Alain Ravaud
No abstract text is available yet for this article.
November 3, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27810259/erratum-to-neoadjuvant-radiotherapy-plus-radical-surgery-for-locally-advanced-stage-iii-iv-oral-cancer-analysis-of-prognostic-factors-affecting-overall-survival-oral-oncol-60-2016-1-7
#3
Christina Eder-Czembirek, Cornelia Czembirek, Edgar Selzer
No abstract text is available yet for this article.
October 31, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27751760/neoantigens-in-immunotherapy-and-personalized-vaccines-implications-for-head-and-neck-squamous-cell-carcinoma
#4
Paul Zolkind, Gavin P Dunn, Tianxiang Lin, Malachi Griffith, Obi L Griffith, Ravindra Uppaluri
The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process and the revolution in next generation sequencing of cancer genomes. Recent evidence suggests that T cell specificity for cancer cell expressed mutant proteins - termed neoantigens - is an important component of immune mediated tumor rejection...
October 14, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27743938/squamous-cell-carcinoma-associated-with-chronic-graft-versus-host-disease-like-lichen-planus-like-lesion-of-the-oral-cavity-in-a-patient-managed-for-metastatic-melanoma-with-a-pd-1-inhibitor-pembrolizumab
#5
Adepitan A Owosho, Joseph Randazzo, Evan B Rosen, Cherry L Estilo, Joseph M Huryn, Ping Chi, SaeHee K Yom
No abstract text is available yet for this article.
October 12, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27651021/does-multiple-biopsies-and-implantation-along-the-needle-tract-augment-for-increased-local-recurrence-in-head-and-neck-neoplasms
#6
P S Satheeshkumar, Minu P Mohan
No abstract text is available yet for this article.
September 17, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27613152/correspondence-on-review-article-published-in-oral-oncology-vol-59-august-2016-evaluation-of-the-benefit-and-use-of-multidisciplinary-teams-in-the-treatment-of-head-and-neck-cancer
#7
Muhammad Atif Mansha, Ahmed Nadeem Abbasi, Nasir Ali, Asim Hafiz, Bilal Mazhar Qureshi
No abstract text is available yet for this article.
September 6, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865377/risk-factors-for-radiation-failure-in-early-stage-glottic-carcinoma-a-systematic-review-and-meta-analysis
#8
Görkem Eskiizmir, Yasemin Baskın, Femin Yalçın, Hülya Ellidokuz, Robert L Ferris
BACKGROUND: Radiotherapy is one of the main treatment modalities for early-stage glottic carcinoma. Unfortunately, local failure may occur in a group of cases with T1-T2 glottic carcinoma. This meta-analysis sought to determine risk factors for radiation failure in patients with early-stage glottic carcinoma. METHODS: A systematic and comprehensive search was performed for related studies published between 1995 and 2014. The primary end-point was 5-year local control...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865376/free-flap-outcome-of-salvage-surgery-compared-to-primary-surgery-for-head-and-neck-defects-a-propensity-score-analysis
#9
Chung-Hwan Baek, Woori Park, Nayeon Choi, Seonhye Gu, Insuk Sohn, Man Ki Chung
OBJECTIVES: To compare free flap outcomes for head and neck defects between primary surgery and salvage surgery and identify factors affecting the outcomes in the two settings. METHODS: A total of 225 patients (primary group, n=56; salvage group, n=169) were retrospectively identified. The salvage group was previously treated with radiotherapy, chemoradiation, surgery, or any combination of these treatments. Clinical data were retrieved and analyzed between the two groups to compare the incidence and contributing factors of flap-related complications and flap failure...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865375/optimize-the-cycle-of-neoadjuvant-chemotherapy-for-locoregionally-advanced-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy-a-propensity-score-matching-analysis
#10
Hao Peng, Lei Chen, Wen-Fei Li, Yuan Zhang, Li-Zhi Liu, Li Tian, Ai-Hua Lin, Ying Sun, Jun Ma
OBJECTIVES: The aim of this study is to optimize the cycle for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) receiving neoadjuvant chemotherapy (NCT) in the era of intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: Data on 569 locoregionally advanced NPC patients treated with IMRT were retrospectively reviewed. Propensity score matching (PSM) method was adopted to balance prognostic factors and match patients. Survival outcomes of matched patients between different NCT cycle groups were compared...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865374/clinical-implications-of-the-extent-of-braf-v600e-alleles-in-patients-with-papillary-thyroid-carcinoma
#11
Lihua Liu, Jae Won Chang, Seung-Nam Jung, Hee Sung Park, Taejeong Oh, Young Chang Lim, Bon Seok Koo
OBJECTIVE: There are many conflicting reports about the clinical implications of BRAF(V600E) in papillary thyroid cancer (PTC). We investigated the associations between the extent of BRAF(V600E) alleles and both clinico-pathological features and recurrence of PTC. MATERIALS AND METHODS: Carcinoma tissues from 60 patients with PTC were genotyped for BRAF(V600E) using pyrosequencing, and the clinico-pathological factors and disease outcomes of the patients were examined...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865373/extracapsular-spread-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#12
REVIEW
Maxime Mermod, Genrich Tolstonog, Christian Simon, Yan Monnier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are still a number of important remaining issues regarding this condition. Indeed, standardized diagnostic and grading criteria of ECS are still lacking. The imaging modality of choice for its diagnosis is a matter of debate. Current research looking at the identification of specific biomarkers is ongoing. Recent findings demonstrate a direct correlation between the level of extension of ECS and a poor prognosis...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865372/phase-ii-study-of-panitumumab-and-paclitaxel-as-first-line-treatment-in-recurrent-or-metastatic-head-and-neck-cancer-ttcc-2009-03-vectitax-study
#13
Elvira Del Barco Morillo, Ricard Mesía, Juan Carlos Adansa Klain, Silvia Vázquez Fernández, Joaquina Martínez-Galán, Miguel Pastor Borgoñon, Cyntia González-Rivas, Javier Caballero Daroqui, Alfonso Berrocal, Javier Martínez-Trufero, Ruth Vera, Juan Jesús Cruz-Hernández
OBJECTIVE: To evaluate the activity and safety profile of panitumumab in combination with paclitaxel in patients with recurrent or metastatic SCCHN. MATERIALS AND METHODS: The VECTITAX phase II, open-label, multicenter study included patients with confirmed metastatic and/or recurrent SCCHN deemed to be untreatable by surgery or radiotherapy and ECOG PS=0-1. All patients received paclitaxel (80mg/m(2)/week) and panitumumab (6mg/kg/2weeks) until disease progression or unacceptable toxicity...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865371/assessing-head-and-neck-cancer-patient-preferences-and-expectations-a-systematic-review
#14
REVIEW
Pierre Blanchard, Robert J Volk, Jolie Ringash, Susan K Peterson, Katherine A Hutcheson, Steven J Frank
INTRODUCTION: To enhance the value of care, interventions should aim at improving endpoints that matter to patients. The preferences of head and neck cancer patients regarding treatment outcomes are therefore a major topic for patient-centered research. METHODS: A systematic review (PROSPERO number CRD42016035692) was conducted by searching electronic databases (Medline, Embase, Cochrane, CINAHL) for articles evaluating patient or surrogate preferences in head and neck cancer...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865370/hypermethylated-znf582-and-pax1-are-effective-biomarkers-for-detection-of-oral-dysplasia-and-oral-cancer
#15
Shih-Jung Cheng, Chi-Feng Chang, Jang-Jaer Lee, Hsin-Ming Chen, Huei-Jen Wang, Yu-Ligh Liou, Carolyn Yen, Chun-Pin Chiang
OBJECTIVES: This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS: Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral precancer patients, and 95 oral squamous cell carcinoma patients. Methylation levels of the five genes were quantified by real-time methylation-specific PCR after bisulfite conversion...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865369/feasibility-of-using-head-and-neck-ct-imaging-to-assess-skeletal-muscle-mass-in-head-and-neck-cancer-patients
#16
Justin E Swartz, Ajit J Pothen, Inge Wegner, Ernst J Smid, Karin M A Swart, Remco de Bree, Loek P H Leenen, Wilko Grolman
OBJECTIVES: Patients with head and neck cancer (HNC) have a higher risk of malnutrition and sarcopenia, which is associated with adverse clinical outcome. As abdominal CT-imaging is often used to detect sarcopenia, such scans are rarely available in HNC patients, possibly explaining why no studies investigate the effect of sarcopenia in this population. We correlated skeletal muscle mass assessed on head and neck CT-scans with abdominal CT-imaging. METHODS: Head and neck, and abdominal CT-scans of trauma (n=51) and HNC-patients (n=52) were retrospectively analyzed...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865368/effect-of-hpv-on-head-and-neck-cancer-patient-survival-by-region-and-tumor-site-a-comparison-of-1362-cases-across-three-continents
#17
Gypsyamber D'Souza, Devasena Anantharaman, Tarik Gheit, Behnoush Abedi-Ardekani, Daniel C Beachler, David I Conway, Andrew F Olshan, Victor Wunsch-Filho, Tatiana N Toporcov, Wolfgang Ahrens, Kathy Wisniewski, Franco Merletti, Stefania Boccia, Eloiza H Tajara, Jose P Zevallos, José Eduardo Levi, Mark C Weissler, Sylvia Wright, Ghislaine Scelo, Angela L Mazul, Massimo Tommasino, Paul Brennan, Gabriella Cadoni
OBJECTIVES: To explore whether HPV-related biomarkers predict oropharyngeal squamous cell cancer (OPSCC) survival similarly across different global regions, and to explore their prognostic utility among non-oropharyngeal (non-OP) head and neck cancers. METHODS: Data from 1362 head and neck SCC (HNSCC) diagnosed 2002-2011 was used from epidemiologic studies in: Brazil (GENCAPO study, n=388), U.S. (CHANCE study, n=472), and Europe (ARCAGE study, n=502). Tumors were centrally tested for p16(INK4a) and HPV16 DNA (by PCR)...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865367/circulating-tumor-stem-like-cells-in-oral-squamous-cell-carcinoma-an-unresolved-paradox
#18
Shanaya Patel, Kavan Shah, Sheefa Mirza, Kanisha Shah, Rakesh Rawal
OBJECTIVE: Circulating tumor cells (CTCs) are increasingly gaining importance due to their immense potential in enhancing diagnosis, prognosis and response to therapy in solid malignancies. Therefore, we aimed to comprehend the molecular diversity and critical role of this disseminated tumor population in OSCC. METHODOLOGY: CD44+ subpopulation was isolated using immuno-magnetic cell separation and their purity was validated using flow cytometry. Characterisation of self renewal potential and resistance to chemotherapy was assessed using tumor sphere forming and cytotoxicity assay...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865366/effects-of-geographic-area-and-socioeconomic-status-in-taiwan-on-survival-rates-of-head-and-neck-cancer-patients-after-radiotherapy
#19
LETTER
Tsu-Jen Kuo, Chi-Hsiang Chu, Pei-Ling Tang, Yu-Cheng Lai
No abstract text is available yet for this article.
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27865365/implications-of-cancer-stem-cells-in-developing-therapeutic-resistance-in-oral-cancer
#20
REVIEW
Prajna Paramita Naik, Durgesh Nandini Das, Prashanta Kumar Panda, Subhadip Mukhopadhyay, Niharika Sinha, Prakash Priyadarshi Praharaj, Rajesh Agarwal, Sujit Kumar Bhutia
Conventional therapeutics are often frequented with recurrences, refraction and regimen resistance in oral cavity cancers which are predominantly manifested by cancer stem cells (CSCs). During oncoevolution, cancer cells may undergo structural and functional reprogramming wherein they evolve as highly tolerant CSC phenotypes with greater survival advantages. The CSCs possess inherent and exclusive properties including self-renewal, hierarchical differentiation, and tumorigenicity that serve as the basis of chemo-radio-resistance in oral cancer...
November 2016: Oral Oncology
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