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Oral Oncology

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https://www.readbyqxmd.com/read/28089208/the-reconstructive-options-for-oropharyngeal-defects-in-the-transoral-robotic-surgery-framework
#1
Giuseppe Meccariello, Filippo Montevecchi, Rossella Sgarzani, Andrea De Vito, Giovanni D'Agostino, Riccardo Gobbi, Chiara Bellini, Claudio Vicini
Transoral robotic surgery (TORS) is a fascinating new technique that has been proved to be a safe and feasible for selected oropharyngeal cancers. Furthermore, TORS offers several advantages in the treatment of locoregionally advanced cancers. Nevertheless, the careful selection of patients is the keypoint for a successful application of this therapeutic modality. However, the reconstruction of large oropharyngeal defects is challenging due to the restoration of velopharyngeal competency and swallowing. Moreover, the absence of mandibular splitting increases the difficulties faced by reconstructive surgeons...
January 11, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28082058/the-importance-of-extranodal-extension-in-metastatic-head-and-neck-squamous-cell-carcinoma-in-the-light-of-the-new-ajcc-cancer-staging-system
#2
LETTER
Claudio Luchini, Nicola Veronese
No abstract text is available yet for this article.
January 9, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28049614/carcinoma-of-buccal-mucosa-with-metastasis-to-thigh
#3
LETTER
Gunjan Agrawal, Ashutosh Gupta, Vivek Chaudhary
No abstract text is available yet for this article.
December 31, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28043765/corrigendum-to-effect-of-hpv-on-head-and-neck-cancer-patient-survival-by-region-and-tumor-site-a-comparison-of-1362-cases-across-three-continents-oral-oncol-62-2016-20-27
#4
Gypsyamber D'Souza, Devasena Anantharaman, Tarik Gheit, Behnoush Abedi-Ardekani, Daniel C Beachler, David I Conway, Andrew F Olshan, Victor Wunsch-Filho, Tatiana N Toporcov, Wolfgang Ahrens, Kathy Wisniewski, Franco Merletti, Stefania Boccia, Eloiza H Tajara, Jose P Zevallos, José Eduardo Levi, Mark C Weissler, Sylvia Wright, Ghislaine Scelo, Angela L Mazul, Massimo Tommasino, Gabriella Cadoni, Paul Brennan
No abstract text is available yet for this article.
December 30, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28024932/corrigendum-to-oral-microbiome-periodontitis-and-risk-of-head-and-neck-cancer-oral-oncol-53-2016-17-19
#5
Leonardo Victor Galvão-Moreira, Maria Carmen Fontoura Nogueira da Cruz
No abstract text is available yet for this article.
December 23, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28017652/atr-gene-mutations-in-hpv-negative-oropharyngeal-cancer
#6
LETTER
Jean-Pierre Jeannon, Akio Tanaka, Selvam Thavaraj, Teresa Guerrero-Urbano, John A McGrath, Mahvash Tavassoli
No abstract text is available yet for this article.
December 22, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28017651/surgical-treatment-of-salivary-malignant-tumors
#7
Davide Lombardi, Marc McGurk, Vincent Vander Poorten, Marco Guzzo, Remo Accorona, Vittorio Rampinelli, Piero Nicolai
Salivary gland malignant tumors (SGMT) are of key interest for head and neck surgeons since surgery with adjuvant radiotherapy is considered the treatment of choice in most of the cases. Some factors, namely rarity, high histologic heterogeneity, and possible occurrence in all the head and neck subsites, contribute to make this topic very controversial; some unclear aspects pertain surgical treatment. When dealing with major salivary gland malignant tumors (MaSGMT), the most debated issues remain the extent of surgery and management of facial nerve...
December 22, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28012797/ataxia-telangiectasia-mutated-interactor-regulates-head-and-neck-cancer-metastasis-via-kras-expression
#8
Yue-Ju Li, Wei-Ting Lai, Cheng-Chi Chang, Mark Yen-Ping Kuo, Yi-Ting Deng, Cheng-Ning Yang, Shih-Jung Cheng, Tai-Sheng Wu, Szu-Ta Chen, Been-Ren Lin
OBJECTIVES: Relapse is the most serious problem affecting the morbidity and mortality rates of patients with head and neck squamous cell carcinoma (HNSCC). Although HNSCC has been studied for several decades, the exact mechanism of cancer recurrence remains unclear. MATERIALS AND METHODS: ataxia-telangiectasia mutated interactor (ATMIN) messenger RNA(mRNA) expression was detected in HNSCC samples by quantitative RT-PCR, and was analyzed with patients' clinical outcomes by Kaplan-Meier analyses...
December 21, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27993466/truth-or-myth-definitive-chemoradiotherapy-doesn-t-work-for-hpv-p16-negative-oropharyngeal-squamous-cell-carcinoma
#9
Bhisham Chera, Kyle Wang, Alan Monroe, Tom Galloway, Robert Amdur, D Neil Hayes, Jose Zevallos, William M Mendenhall
No abstract text is available yet for this article.
December 16, 2016: Oral Oncology
https://www.readbyqxmd.com/read/27993465/epithelial-dysplasia-must-be-treated
#10
LETTER
Shivani Bansal, Rajiv S Desai, Pankaj M Shirsat, Pooja Prasad
No abstract text is available yet for this article.
December 16, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28024728/laryngeal-tumours-and-radiotherapy-dose-to-the-cricopharyngeus-are-predictive-of-death-from-aspiration-pneumonia
#11
Jolyne O'Hare, Julia Maclean, Michal Szczesniak, Rashmi Gupta, Peter Wu, Harry Quon, Ian Cook, Peter Graham
OBJECTIVES: Aspiration pneumonia is an under-reported treatment sequelae following radiotherapy for head and neck cancer (HNC) patients. This study aims to investigate its incidence and risk factors in this population. MATERIALS AND METHODS: A retrospective review of all HNC patients that had received radiotherapy or chemo radiotherapy with radical intent at a single institution was undertaken (n=206). Dose delivered to the pharyngeal constrictors, base of tongue and cricopharyngeus was calculated and compared between those patients who had died from aspiration pneumonia and those who are alive or had died from other causes...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024727/refining-the-definition-of-mandibular-osteoradionecrosis-in-clinical-trials-the-cancer-research-uk-hopon-trial-hyperbaric-oxygen-for-the-prevention-of-osteoradionecrosis
#12
Richard Shaw, Binyam Tesfaye, Matt Bickerstaff, Paul Silcocks, Christopher Butterworth
INTRODUCTION: Mandibular osteoradionecrosis (ORN) is a common and serious complication of head and neck radiotherapy for which there is little reliable evidence for prevention or treatment. The diagnosis and classification of ORN have been inconsistently and imprecisely defined, even in clinical trials. METHODS: A systematic review of diagnosis and classifications of ORN with specific focus on clinical trials is presented. The most suitable classification was evaluated for consistency using blinded independent review of outcome data (clinical photographs and radiographs) in the HOPON trial...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024726/defining-the-boundaries-and-expanding-the-utility-of-head-and-neck-cancer-patient-derived-xenografts
#13
Adam D Swick, Andrew P Stein, Timothy M McCulloch, Gregory K Hartig, Irene M Ong, Emmanuel Sampene, Prashanth J Prabakaran, Cheng Z Liu, Randall J Kimple
BACKGROUND: Patient derived xenografts (PDXs) represent an essential tool in oncologic research, and we sought to further expand our repertoire of head and neck squamous cell carcinoma (HNSCC) while determining potential boundaries for this system. METHODS: We consented new patients for PDX development and determined if a 24-h time delay from tumor excision to xenograft implantation affected PDX establishment. We developed a tissue microarray (TMA) from formalin fixed, paraffin embedded PDXs and their subsequent passages and carried out quantitative immunohistochemistry for EGFR, pEGFR, pAkt, pERK and ERCC1...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024725/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-recommendations-and-head-and-neck-cancers-risk
#14
Francesca Bravi, Jerry Polesel, Werner Garavello, Diego Serraino, Eva Negri, Gianni Franchin, Carlo La Vecchia, Cristina Bosetti
OBJECTIVES: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. MATERIALS AND METHODS: We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024724/a-ppar-gamma-agonist-protects-against-oral-mucositis-induced-by-irradiation-in-a-murine-model
#15
Monica Mangoni, Mariangela Sottili, Chiara Gerini, Isacco Desideri, Cinzia Bastida, Stefania Pallotta, Francesca Castiglione, Pierluigi Bonomo, Icro Meattini, Daniela Greto, Emanuela Olmetto, Francesca Terziani, Carlotta Becherini, Camilla Delli Paoli, Laura Trombetta, Mauro Loi, Giampaolo Biti, Lorenzo Livi
BACKGROUND: Due to its anti-inflammatory, antifibrotic and antineoplastic properties, the PPAR gamma agonist rosiglitazone is of interest in prevention and therapy of radiation-induced toxicities. We aimed to evaluate the radioprotective effect of rosiglitazone in a mouse model of radiation-induced oral mucositis. MATERIAL AND METHODS: Oral mucositis was obtained by irradiation of the oral region of C57BL/6J mice, pretreated or not with rosiglitazone. Mucositis was assessed by macroscopic scoring, histology and molecular analysis...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024723/the-prevalence-and-risk-factors-associated-with-osteoradionecrosis-of-the-jaw-in-oral-and-oropharyngeal-cancer-patients-treated-with-intensity-modulated-radiation-therapy-imrt-the-memorial-sloan-kettering-cancer-center-experience
#16
Adepitan A Owosho, C Jillian Tsai, Ryan S Lee, Haley Freymiller, Arvin Kadempour, Spyridon Varthis, Adi Z Sax, Evan B Rosen, SaeHee K Yom, Joseph Randazzo, Esther Drill, Elyn Riedel, Snehal Patel, Nancy Y Lee, Joseph M Huryn, Cherry L Estilo
OBJECTIVE: To determine the prevalence and correlation of various risk factors [radiation dose, periodontal status, alcohol and smoking] to the development of osteoradionecrosis (ORN). PATIENTS AND METHODS: The records of 1023 patients treated with IMRT for oral cavity cancer (OCC) and oropharyngeal cancer (OPC) between 2004 and 2013 were retrospectively reviewed to identify patients who developed ORN. Fisher exact tests were used to analyze patient characteristics between ORN patients with OCC and OPC...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024722/the-role-of-hpv-on-the-risk-of-second-primary-neoplasia-in-patients-with-oropharyngeal-carcinoma
#17
María Martel, Laia Alemany, Miren Taberna, Marisa Mena, Sara Tous, Silvia Bagué, Xavier Castellsagué, Miquel Quer, Xavier León
OBJECTIVES: It has been reported that patients with HPV-positive oropharyngeal cancer (OPC) have a lower risk of appearance of second primary neoplasm (SPN) than HPV-negative OPC patients. The aim of our study was to analyze the risk of developing SPN in a large group of patients with OPC according to HPV status in the primary tumor. MATERIALS AND METHODS: We included 412 OPC patients treated at our center from 1991 to 2014 for which the HPV DNA positivity was evaluated by PCR in available tumor specimens...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024721/functional-and-cognitive-impairment-social-environment-frailty-and-adverse-health-outcomes-in-older-patients-with-head-and-neck-cancer-a-systematic-review
#18
REVIEW
Floor J van Deudekom, Anouk S Schimberg, Marije H Kallenberg, Marije Slingerland, Lily-Ann van der Velden, Simon P Mooijaart
OBJECTIVES: Older head and neck cancer patients are at increased risk for adverse health outcomes, but little is known about which geriatric assessment associates with poor outcome. The aim is to study the association of functional or cognitive impairment, social environment and frailty with adverse health outcomes in patients with head and neck cancer. METHODS: Four libraries were searched for studies reporting on an association of functional or cognitive impairment, social environment and frailty with adverse outcomes in head and neck cancer patients...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024720/healthy-life-expectancy-of-oral-squamous-cell-carcinoma-patients-aged-75years-and-older
#19
Shin-Ichi Yamada, Hiroshi Kurita, Takahiro Tomioka, Ryousuke Ohta, Nobuhiko Yoshimura, Fumihiro Nishimaki, Yoshihito Koyama, Eiji Kondo, Takahiro Kamata
OBJECTIVES: Healthy life expectancy, an extension of the concept of life expectancy, is a summary measure of population health that takes into account the mortality and morbidity of a population. The aim of the present study was to retrospectively analyze the self-reliance survival times of oral squamous cell carcinoma (OSCC) patients. MATERIALS AND METHODS: One hundred and twelve patients aged 75years or older with primary OSCC were included and examined at Shinshu University Hospital...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28024719/prognostic-impact-of-adjuvant-chemotherapy-in-high-risk-nasopharyngeal-carcinoma-patients
#20
Yi-Chun Liu, Wen-Yi Wang, Chih-Wen Twu, Rong-San Jiang, Kai-Li Liang, Ching-Te Wu, Po-Ju Lin, Jing-Wen Huang, He-Yuan Hsieh, Jin-Ching Lin
OBJECTIVES: To investigate the prognostic impact of adjuvant chemotherapy (AdjCT) in patients with high-risk nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: A total 403 NPC patients with at least one of the following criteria (1) neck node>6cm; (2) supraclavicular node metastasis; (3) skull base destruction/intracranial invasion plus multiple nodes metastasis; or (4) multiple neck nodes metastasis with one of nodal size>4cm were retrospectively reviewed...
January 2017: Oral Oncology
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