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Oral Oncology

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https://www.readbyqxmd.com/read/29980410/primary-carcinoma-ex-pleomorphic-adenoma-of-anterior-commissure-of-the-larynx
#1
LETTER
Josef Kovarik, Debra Milne, Max Robinson, Frank Stafford, Muhammad Shahid Iqbal
No abstract text is available yet for this article.
July 3, 2018: Oral Oncology
https://www.readbyqxmd.com/read/29941329/letter-to-the-editor-utility-of-pet-ct-in-detecting-nodal-metastasis-in-cn0-early-stage-oral-cavity-squamous-cell-carcinoma
#2
LETTER
Yubin Cao, Chunjie Li, Longjiang Li
No abstract text is available yet for this article.
June 22, 2018: Oral Oncology
https://www.readbyqxmd.com/read/29941328/the-possible-contemporary-presence-of-bronj-and-oral-squamous-cell-carcinoma
#3
LETTER
Valentina Terenzi, Andrea Cassoni, Edoardo Coiante, Davide Spadoni, Carlo Della Rocca, Angelina Pernazza, Valentino Valentini
No abstract text is available yet for this article.
June 22, 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909908/the-epidemiology-of-oral-human-papillomavirus-infection-in-healthy-populations-a-systematic-review-and-meta-analysis
#4
REVIEW
Samantha Tam, Shuangshuang Fu, Li Xu, Kate J Krause, David R Lairson, Hongyu Miao, Erich M Sturgis, Kristina R Dahlstrom
Human papillomavirus (HPV) is a potentially oncogenic sexually transmitted infection. As the incidence of oropharyngeal cancer (OPC) caused by oral HPV infections is rising, further investigation into the natural history of such infections is needed. This systematic review and meta-analysis aimed to synthesize data on the prevalence, incidence, clearance, and persistence of oral HPV infections in healthy individuals. A systematic review of literature published between January 1995 and August 2017 was conducted using Ovid MEDLINE, PubMed, Embase, and the Cochrane Library...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909907/randomized-phase-ii-trial-of-cixutumumab-alone-or-with-cetuximab-for-refractory-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma
#5
Renata Ferrarotto, William N William, Jennifer E Tseng, Shanthi Marur, Dong M Shin, Barbara Murphy, Ezra E W Cohen, Christopher Y Thomas, Richard Willey, Jan Cosaert, Nusrat Harun, J Jack Lee, Ignacio W Wistuba, Robert I Haddad, Bonnie S Glisson
OBJECTIVES: Cixutumumab (CIX) and cetuximab (CET) monoclonal antibodies block ligand-binding to insulin-like growth factor-1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) respectively. The objective of this study was to assess the efficacy of CIX alone or combined with CET in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients. METHODS: In this open-label phase II trial, 91 R/M HNSCC patients who progressed within 90 days of platinum-based chemotherapy, were randomized to CIX 10 mg/kg alone or with CET 500 mg/m2 every 2 weeks...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909906/microrna-155-185-and-193b-as-biomarkers-in-human-papillomavirus-positive-and-negative-tonsillar-and-base-of-tongue-squamous-cell-carcinoma
#6
Cinzia Bersani, Michael Mints, Nikolaos Tertipis, Linnea Haeggblom, Anders Näsman, Mircea Romanitan, Tina Dalianis, Torbjörn Ramqvist
OBJECTIVE: Three-year disease-free survival (DFS) is 80% for human papillomavirus (HPV) positive tonsillar and base of tongue cancer (TSCC/BOTSCC) treated with radiotherapy alone, and today's intensified therapy does not improve prognosis. More markers are therefore needed to more accurately identify patients with good prognosis or in need of alternative therapy. Here, microRNAs (miRs) 155, 185 and 193b were examined as potential prognostic markers in TSCC/BOTSCC. MATERIAL AND METHODS: 168 TSCC/BOTSCC patients diagnosed 2000-2013, with known data on HPV-status, CD8+ tumour infiltrating lymphocytes, tumour staging and survival were examined for expression of miR-155, -185 and -193b using Real-Time PCR...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909905/dysfunction-of-hpv16-specific-cd8-t-cells-derived-from-oropharyngeal-tumors-is-related-to-the-expression-of-tim-3-but-not-pd-1
#7
Kamila Hladíková, Simona Partlová, Vladimír Koucký, Jan Bouček, Jean-Francois Fonteneau, Michal Zábrodský, Ruth Tachezy, Marek Grega, Radek Špíšek, Anna Fialová
BACKGROUND: Human papillomavirus (HPV) type 16 infection is one of the most important etiological agents of oropharyngeal squamous cell carcinoma. Patients with HPV-associated carcinomas of the head and neck were reported to have a better clinical outcome than patients with HPV-negative tumors. Because HPV16 E6 and E7 oncoproteins are highly immunogenic and constitutively expressed, HPV-specific T cell immunity may play the key role in improving the prognosis of these patients. METHODS: Tumor-derived T cells were expanded in high levels of IL-2 and stimulated with HPV16 E6/E7 peptides in the presence or absence of anti-PD-1 monoclonal antibody nivolumab and soluble Tim-3...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909904/web-based-information-on-oral-dysplasia-and-precancer-of-the-mouth-quality-and-readability
#8
Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
OBJECTIVES: The numbers of individuals with oral cancer are increasing. This cancer is preceded by oral epithelial dysplasia (OED). There remains no detailed study of the online information presently available for patients with OED or indeed what information such patients may require to be appropriately informed regarding their condition. Hence, the aim of the present study is to assess the patient-oriented web content with respect to OED. METHODS: The first 100 websites yielded from nine searches performed using different search terms and engines were considered...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909903/systemic-therapy-in-non-conventional-cancers-of-the-larynx
#9
REVIEW
Elaine Tan, Mayur D Mody, Nabil F Saba
Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. There is a lack of guidelines regarding the best therapeutic approaches to these tumors and their treatment is often modeled after their recommended management at non-laryngeal sites. Understanding the role for systemic therapy in these rare tumors is important, especially for patients with advanced disease or those who are not surgical candidates...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909902/outcomes-and-prognostic-factors-for-parotid-acinic-cell-carcinoma-a-national-cancer-database-study-of-2362-cases
#10
Claudia Scherl, Masanari G Kato, Evren Erkul, Evan M Graboyes, Shaun A Nguyen, Angela C Chi, Patrick F Morgan, Terry A Day
OBJECTIVES: To evaluate the demographics, clinical features, survival outcomes, and prognostic indicators of patients with acinic cell carcinoma (ACC) of the parotid gland with emphasis on the roles of grade, tumor size, and nodal status in survival. MATERIALS AND METHODS: A retrospective analysis of cases diagnosed between 2004 and 2012 from the National Cancer Database was performed. Multivariable logistic regression was used to determine factors associated with survival...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909901/primary-thyroid-angiosarcoma-a-systematic-review
#11
REVIEW
F De Felice, E Moscatelli, S Orelli, N Bulzonetti, D Musio, V Tombolini
Thyroid angiosarcoma (TAS) is rare and represents a very aggressive malignancy. Its rarity is principally linked to two major pitfalls. Firstly, TAS histopathology diagnosis can be difficult; second, the limited clinical experience with this condition can make its management complex. We conducted a detailed systematic review, focusing on the knowledge available regarding TAS etiopathogenesis, treatment options and prognosis. The aim is to present the main TAS characteristics and to summarize the clinical experiences described worldwide, in order to provide a useful clinical tool...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909900/mat%C3%A3-consumption-association-with-upper-aerodigestive-tract-cancers-a-systematic-review-and-meta-analysis
#12
REVIEW
Fernanda Weber Mello, Fernanda Marcello Scotti, Gilberto Melo, Saman Warnakulasuriya, Eliete Neves Silva Guerra, Elena Riet Correa Rivero
Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté consumption and occurrence of the UADT cancer?". Studies investigating any association between maté consumption and occurrence of UADT cancer were included. Out of the 569 studies, 18 met the inclusion criteria for qualitative and 15 for quantitative analysis...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909899/human-papillomavirus-detection-in-gargles-tonsil-brushings-and-frozen-tissues-in-cancer-free-patients
#13
J D Combes, C Clavel, V Dalstein, T Gheit, G M Clifford, M Tommasino, S Franceschi, J Lacau St Guily
No abstract text is available yet for this article.
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909898/clinicopathological-characteristics-and-outcome-of-31-patients-with-etv6-ntrk3-fusion-gene-confirmed-mammary-analogue-secretory-carcinoma-of-salivary-glands
#14
E Boon, M H Valstar, W T A van der Graaf, E Bloemena, S M Willems, C A Meeuwis, P J Slootweg, L A Smit, M A W Merkx, R P Takes, J H A M Kaanders, P J T A Groenen, U E Flucke, C M L van Herpen
OBJECTIVES: In 2010, a new subtype of salivary gland cancer (SGC), (mammary analogue) secretory carcinoma (SC), was defined, characterized by the ETV6-NTRK3 fusion gene. As clinical behavior and outcome data of this histological subtype tumor are still sparse, we aimed to describe the clinicopathological course and outcome of a series of translocation positive SC patients. PATIENT AND METHODS: We re-evaluated the pathological diagnosis of a subset of SGCs, diagnosed in 4 of 8 Dutch head and neck centers...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909897/ajcc-8th-edition-oral-cavity-squamous-cell-carcinoma-staging-is-it-an-improvement-on-the-ajcc-7th-edition
#15
Katherine Pollaers, Anton Hinton-Bayre, Peter L Friedland, Camile S Farah
OBJECTIVES: To explore the prognostic and discriminatory ability of the AJCC 8th Edition Oral Cavity cancer staging in a non-North American population, and compare it to the previously used AJCC 7th Edition. MATERIALS AND METHODS: Retrospective chart review was performed at a tertiary referral Otolaryngology, Head Neck and Skull Base Department in Australia, from June 2002 to June 2017. Oral cavity squamous cell carcinoma cases were staged according to AJCC 8th Edition, which was compared to AJCC 7th Edition staging, for disease-free survival (DFS) and overall survival (OS)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909896/sentinel-node-biopsy-in-early-oral-squamous-cell-carcinomas-long-term-follow-up-and-nodal-failure-analysis
#16
A Moya-Plana, A Aupérin, J Guerlain, P Gorphe, O Casiraghi, G Mamelle, A Melkane, J Lumbroso, F Janot, S Temam
OBJECTIVES: Evaluate the reliability of sentinel node biopsy (SNB) in T1/T2 cN0 oral squamous cell carcinoma (OSCC), and compare recurrence-free time (RFT) and overall survival (OS) between patients undergoing SNB and neck dissection (ND). PATIENTS AND METHODS: Patients with T1/T2 cN0 OSCC underwent SNB followed by systematic ND in the first cohort and SNB followed by selective ND in case of positive sentinel nodes (SN) in the second cohort. RESULTS: A total of 229 patients were followed (first cohort 50, second cohort 179)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909895/magnitude-of-benefit-for-adjuvant-radiotherapy-following-minimally-invasive-surgery-in-intermediate-to-high-risk-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#17
Dario Pasalic, Ryan K Funk, Joaquín J García, Daniel L Price, Katharine A Price, William S Harmsen, Samir H Patel, Geoffrey D Young, Robert L Foote, Eric J Moore, Daniel J Ma
OBJECTIVE: To determine the outcomes and toxicities of minimally-invasive surgery with adjuvant intensity-modulated radiotherapy +/- chemotherapy (AT) compared to definitive surgical therapy (ST) in a contemporary cohort of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). METHODS: From 2005 to 2013, a consecutive cohort of 190 HPV-positive OPSCC patients was retrospectively reviewed from multi-institutional databases maintained by the Departments of Otorhinolaryngology and Radiation Oncology...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909894/investigation-of-the-surgical-strategies-for-unilateral-multifocal-cystadenolymphomas-of-the-parotid-gland
#18
Konstantinos Mantsopoulos, Michael Koch, Miguel Goncalves, Heinrich Iro
OBJECTIVES: The aim of the study was to compare multifocal extracapsular dissection with complete parotidectomy in the treatment of unilateral multifocal cystadenolymphomas of the parotid gland. MATERIALS AND METHODS: The records from all patients treated for unilateral multifocal cystadenolymphomas of the parotid gland at a tertiary referral center between 2000 and 2016 were retrospectively analyzed. RESULTS: 203 patients were included in the study...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909893/impact-of-radical-treatments-on-survival-in-locally-advanced-t4a-and-t4b-buccal-mucosa-cancers-selected-surgically-treated-t4b-cancers-have-similar-control-rates-as-t4a
#19
Manish D Mair, Noopur Sawarkar, Santosh Nikam, Rajiv Sarin, Deepa Nair, Tejpal Gupta, Pankaj Chaturvedi, Anil D'cruz, Sudhir Nair
INTRODUCTION: In the absence of any robust data supporting the TNM classification of T4 buccal mucosa cancers, we did this prospective study to compare the oncologic outcomes of T4a and T4b buccal mucosa cancer patients. PATIENTS AND METHODS: This is a prospective study of 210 treatment naïve T4 buccal mucosa cancer patients. All patients underwent upfront radical surgery followed by adjuvant radiotherapy (RT)/chemoradiotherapy (CCRT). This is the largest prospective series in the literature on T4 buccal cancers...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909892/hey1-is-expressed-independent-of-notch1-and-is-associated-with-poor-prognosis-in-head-and-neck-squamous-cell-carcinoma
#20
Eleni M Rettig, Justin A Bishop, Nishant Agrawal, Christine H Chung, Rajni Sharma, Fernando Zamuner, Ryan J Li, Wayne M Koch, Joseph A Califano, Theresa Guo, Daria A Gaykalova, Carole Fakhry
OBJECTIVES: Notch signaling is frequently altered in head and neck squamous cell carcinoma (HNSCC). However, the nature and clinical implications of this dysregulation are not well understood. We previously described an association of transcriptionally active NOTCH1 Intracellular Domain (NICD1) immunohistochemical (IHC) expression pattern with high-risk pathologic characteristics. Here we further characterize Notch signaling in HNSCC. MATERIALS AND METHODS: IHC expression patterns and clinicopathologic associations of Notch pathway molecules were evaluated among 78 tumors with known NOTCH1 mutation status...
July 2018: Oral Oncology
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