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Oral Oncology

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https://www.readbyqxmd.com/read/28325631/new-concepts-of-personalized-therapy-in-salivary-gland-carcinomas
#1
REVIEW
Gunter Keller, Diana Steinmann, Alexander Quaas, Viktor Grünwald, Stefan Janssen, Kais Hussein
Salivary gland carcinomas are rare tumours and therapy strategies are less standardized than in lung, gastric or breast cancer. Therapy is based on surgery, but not all carcinomas are completely resectable, e.g. because carcinomas often show infiltration of nerves. For further therapy decision pathology is recommended, but evaluation of potential targets for personalized therapy is not part of the routine panel. Many salivary gland carcinomas can be resistant to radio- and/or chemotherapy, which limits therapeutic options...
March 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28254238/corrigendum-to-hidden-scar-submandibular-gland-excision-using-an-endoscope-assisted-hairline-approach-oral-oncol-65-2017-83-88
#2
Seung Hoon Woo, Jung Je Park, MinSu Kwon, Jin Pyeong Kim
No abstract text is available yet for this article.
February 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28222967/clinical-implications-of-microscopic-extrathyroidal-extension-in-patients-with-papillary-thyroid-carcinoma
#3
Ji Su Park, Jae Won Chang, Lihua Liu, Seung-Nam Jung, Bon Seok Koo
BACKGROUND: Extrathyroidal extension (ETE) is a poor prognostic factor in papillary thyroid carcinoma (PTC). However, the impact of the degree of ETE, especially microscopic ETE, has not been well established. The purpose of present study was to compare differences in clinicopathological characteristics and clinical outcomes according to the presence or extent of ETE. METHODS: Data from 381 patients who underwent total thyroidectomy with/without lymph node (LN) dissection for PTC between 2004 and 2010 were analyzed...
February 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28202215/erratum-to-cytoreductive-surgery-for-head-and-neck-squamous-cell-carcinoma-in-the-new-age-of-immunotherapy-oral-oncol-61-2016-166-176
#4
R Bryan Bell, Michael J Gough, Steven K Seung, Zeljka Jutric, Andrew D Weinberg, Bernard A Fox, Marka R Crittenden, Rom S Leidner, Brendan Curti
No abstract text is available yet for this article.
February 12, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249655/salivary-gland-pleomorphic-adenoma-in-the-netherlands-a-nationwide-observational-study-of-primary-tumor-incidence-malignant-transformation-recurrence-and-risk-factors-for-recurrence
#5
M H Valstar, M de Ridder, E C van den Broek, M M Stuiver, B A C van Dijk, M L F van Velthuysen, A J M Balm, L E Smeele
INTRODUCTION: Whereas salivary gland pleomorphic adenoma (SGPA) is the most common type of salivary gland tumor, little is known about its epidemiology because national cancer registries do not register this disease. OBJECTIVES: To establish SGPA incidence trends, rates of secondary malignant transformation and recurrence and associated factors in the Netherlands. MATERIALS AND METHODS: Data on incidence, epidemiology, secondary malignant transformation and recurrence were retrieved from the Dutch pathology registry (PALGA) for the years 1992, 1997, 2002, 2007, and 2012...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249654/transoral-robotic-surgery-for-management-of-cervical-unknown-primary-squamous-cell-carcinoma-updates-on-efficacy-surgical-technique-and-margin-status
#6
Mathew Geltzeiler, Sean Doerfler, Meghan Turner, William Greer Albergotti, Mark Kubik, Seungwon Kim, Robert Ferris, Umamaheswar Duvvuri
IMPORTANCE: Management of cervical unknown primary squamous cell carcinoma (CUP) has evolved with the introduction of transoral robotic surgery (TORS). OBJECTIVES: 1. To describe the efficacy of TORS lingual and palatine tonsillectomy in identifying the primary site of malignancy. 2. To explore how the extent of surgery affects diagnostic yield. 3. To report margin status of TORS resections. DESIGN, SETTING AND PARTICIPANTS: A retrospective, single-center cohort study utilizing a prospectively collected database of CUP patients in a high-volume tertiary referral center...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249653/management-of-the-clinically-node-negative-neck-in-squamous-cell-carcinoma-of-the-maxilla
#7
Michiel H M A Joosten, Remco de Bree, Ellen M Van Cann
OBJECTIVE: The management of the clinically node negative (N0) neck in patients with squamous cell carcinoma of the maxilla (MSCC) is a matter of debate. In this retrospective cohort study the incidence of occult metastases is determined in clinically N0 MSCCs, as well as histopathological factors associated with occult metastases. PATIENTS AND METHODS: 95 patients with clinically N0 MSCCs had maxillectomy. 18 patients with elective treatment of the neck were excluded...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249652/validation-of-the-icon-s-staging-for-hpv-associated-oropharyngeal-carcinoma-using-a-pre-defined-treatment-policy
#8
Sandro V Porceddu, Rob Milne, Elizabeth Brown, Anne Bernard, Reza Rahbari, Bena Cartmill, Matthew Foote, Margaret McGrath, Jermaine Coward, Benedict Panizza
OBJECTIVES: To determine whether the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) for HPV associated oropharyngeal carcinoma (HPV+OPC) is a better discriminator of overall survival (OS), compared with the 7th edition (7th Ed) AJCC/UICC TNM staging following curative radiotherapy (RT). MATERIAL AND METHODS: The 5-year OS for all patients with non-metastatic (M0) p16-confirmed OPC treated between 2005 and 2015 was determined and grouped based on the 7th Ed AJCC/UICC TNM and ICON-S staging...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249651/symptom-burden-and-dysphagia-associated-with-osteoradionecrosis-in-long-term-oropharynx-cancer-survivors-a-cohort-analysis
#9
Angela T T Wong, Stephen Y Lai, G Brandon Gunn, Beth M Beadle, Clifton D Fuller, Martha P Barrow, Theresa M Hofstede, Mark S Chambers, Erich M Sturgis, Abdallah Sherif Radwan Mohamed, Jan S Lewin, Katherine A Hutcheson
OBJECTIVE: The purpose is to examine the relationship between mandibular osteoradionecrosis (ORN) and chronic dysphagia in long-term oropharynx cancer (OPC) survivors, and to determine the perceived symptom burden associated with ORN. MATERIALS AND METHODS: Medical records of 349 OPC patients treated with bilateral IMRT and systemic therapy were reviewed. ORN was graded using a published 4-point classification schema. Patients were considered to have chronic dysphagia if they had aspiration pneumonia, stricture or aspiration detected by fluoroscopy or endoscopy, and/or feeding tube dependence in long-term follow-up ⩾1year following radiotherapy...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249650/interventions-for-the-management-of-radiotherapy-induced-xerostomia-and-hyposalivation-a-systematic-review-and-meta-analysis
#10
REVIEW
Valeria Mercadante, Arwa Al Hamad, Giovanni Lodi, Stephen Porter, Stefano Fedele
INTRODUCTION: Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic review and meta-analysis to estimate the effectiveness of available interventions for radiotherapy-induced xerostomia and hyposalivation. METHODS: We searched MEDLINE, Cochrane Central, EMBASE, AMED, and CINAHL database through July 2016 for randomised controlled trials comparing any topical or systemic intervention to active and/or non-active controls for the treatment of radiotherapy-induced xerostomia...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249649/systemic-therapy-in-metastatic-salivary-gland-carcinomas-a-pathology-driven-paradigm
#11
REVIEW
Salvatore Alfieri, Roberta Granata, Cristiana Bergamini, Carlo Resteghini, Paolo Bossi, Lisa F Licitra, Laura D Locati
Salivary gland carcinomas (SGCs) represent one of the most complex tumors from a pathological point of view. According to the World Health Organization (WHO) classification (2005), twenty-four malignant histotypes are recognized, almost all characterized by specific morphological and genetic features as well as by particular clinical behavior. Loco-regional relapse and distant metastases are quite common. Distant metastases are diagnosed in 25-55% of the patients and only 20% of them are alive after 5years...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249648/prevalence-of-human-papillomavirus-in-tonsil-brushings-and-gargles-in-cancer-free-patients-the-split-study
#12
Jean-Damien Combes, Véronique Dalstein, Tarik Gheit, Gary M Clifford, Massimo Tommasino, Christine Clavel, Jean Lacau St Guily, Silvia Franceschi
OBJECTIVE: To evaluate human papillomavirus (HPV) prevalence in the tonsil using extensive ex vivo brushing and gargling in a large age-stratified sample of cancer-free patients. MATERIALS AND METHODS: From 2012 to 2016, consecutive patients undergoing tonsillectomy for benign indications in 19 French University Hospitals were invited to participate in the SPLIT study. Immediately after resection, half-tonsils were extensively brushed at the pathology laboratories on the surface epithelium and in tonsil crypts to collect exfoliated cells...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249647/a-clinicopathologic-study-on-ss18-fusion-positive-head-and-neck-synovial-sarcomas
#13
Adepitan A Owosho, Cherry L Estilo, Evan B Rosen, SaeHee K Yom, Joseph M Huryn, Cristina R Antonescu
OBJECTIVE: To determine clinicopathologic factors on survival in patients with head and neck synovial sarcoma. PATIENTS AND METHODS: We retrospectively identified patients with molecularly confirmed synovial sarcomas of the head and neck (SS-HN), either by the presence of SS18-SSX fusion transcript by RT-PCR or SS18 gene rearrangement by FISH, who were managed at our institution over a 20-year period (1996-2015). Kaplan-Meier survival analysis and log-rank test were performed to evaluate variables related to disease specific survival (DSS)...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249646/chromosomal-abnormalities-and-molecular-landscape-of-metastasizing-mucinous-salivary-adenocarcinoma
#14
Alex Panaccione, Yi Zhang, Yanfang Mi, Yoshitsugu Mitani, Guo Yan, Manju L Prasad, W Hayes McDonald, Adel K El-Naggar, Wendell G Yarbrough, Sergey V Ivanov
BACKGROUND: Mucinous adenocarcinoma of the salivary gland (MAC) is a lethal cancer with unknown molecular etiology and a high propensity to lymph node metastasis. Mostly due to its orphan status, MAC remains one of the least explored cancers that lacks cell lines and mouse models that could help translational and pre-clinical studies. Surgery with or without radiation remains the only treatment modality but poor overall survival (10-year, 44%) underscores the urgent need for mechanism-based therapies...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249645/adjuvant-therapies-utilization-pattern-and-survival-outcomes-in-high-grade-head-and-neck-soft-tissue-sarcoma-a-population-based-study
#15
Omar Mahmoud, Robert Beck, Evelyne Kalyoussef, Richard Chan Park, Soly Baredes, Sung Kim, Michael A Samuels
PURPOSE: Head and neck soft tissue sarcoma (HNSTS) is a distinct entity within the soft tissue sarcoma group and the evidence supporting treatment options for this disease is poorly defined. Using the National Cancer Database, this study aims to reveal adjuvant therapy utilization patterns and their outcomes. MATERIALS: HNSTS patients constituted 6.5% of all sarcoma patients and the analysis was limited to non-metastatic patients who underwent resection between 2004 and 2012...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249644/lymph-node-characteristics-for-predicting-locoregional-recurrence-of-papillary-thyroid-cancer-in-adolescents-and-young-adults
#16
Yungang Sun, Xiang Liu, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang
PURPOSE: To determine lymph node (LN) characteristics predictive of locoregional recurrence (LRR) in adolescent and young adult (AYA) ages 15-39years presenting with papillary thyroid cancer (PTC) and cervical pathologically proven LN metastases (pN1). METHODS AND MATERIALS: Retrospective chart review was performed for all patients with PTC and nodal metastases who had undergone total thyroidectomy, LN dissection, and postoperative radioactive iodine therapy in a university hospital between 2006 and 2014...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249643/chromosome-instability-in-tumor-resection-margins-of-primary-oscc-is-a-predictor-of-local-recurrence
#17
Damiana D C G Pierssens, Maarten C Borgemeester, Stijn J H van der Heijden, Carine J Peutz-Kootstra, Andrea M Ruland, Annick M Haesevoets, Peter A W H Kessler, Bernd Kremer, Ernst-Jan M Speel
BACKGROUND: The local recurrence rate in oral squamous cell cancer (OSCC) hardly decreases. This is partly due to the presence of (pre)malignant cells in the remaining tissue after resection, that may lead to the development of a new tumor in time. Detection of histologically (pre)malignant cells in the tumor resection margins should predict these patients at risk for recurrence, however this appears to be difficult in routine practice. Purpose of this study was to apply easy-to-use molecular tests for more accurate detection of (pre)malignant cells in histopathologically tumor-free margins, to improve diagnosis of patients at risk...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249642/preclinical-upar-targeted-multimodal-imaging-of-locoregional-oral-cancer
#18
M C Boonstra, P B A A Van Driel, S Keereweer, H A J M Prevoo, M A Stammes, V M Baart, C W G M Löwik, A P Mazar, C J H van de Velde, A L Vahrmeijer, C F M Sier
OBJECTIVES: Establishing adequate resection margins and lymphatic mapping are crucial for the prognosis of oral cancer patients. Novel targeted imaging modalities are needed, enabling pre- and intraoperative detection of tumour cells, in combination with improved post-surgical examination by the pathologist. The urokinase-receptor (uPAR) is overexpressed in head and neck cancer, where it is associated with tumour progression and metastasis. MATERIAL AND METHODS: To determine suitability of uPAR for molecular imaging of oral cancer surgery, human head and neck tumours were sectioned and stained for uPAR to evaluate the expression pattern compared to normal mucosa...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28089208/the-reconstructive-options-for-oropharyngeal-defects-in-the-transoral-robotic-surgery-framework
#19
Giuseppe Meccariello, Filippo Montevecchi, Rossella Sgarzani, Andrea De Vito, Giovanni D'Agostino, Riccardo Gobbi, Chiara Bellini, Claudio Vicini
Transoral robotic surgery (TORS) is a fascinating new technique that has been proved to be a safe and feasible for selected oropharyngeal cancers. Furthermore, TORS offers several advantages in the treatment of locoregionally advanced cancers. Nevertheless, the careful selection of patients is the keypoint for a successful application of this therapeutic modality. However, the reconstruction of large oropharyngeal defects is challenging due to the restoration of velopharyngeal competency and swallowing. Moreover, the absence of mandibular splitting increases the difficulties faced by reconstructive surgeons...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28082058/the-importance-of-extranodal-extension-in-metastatic-head-and-neck-squamous-cell-carcinoma-in-the-light-of-the-new-ajcc-cancer-staging-system
#20
LETTER
Claudio Luchini, Nicola Veronese
No abstract text is available yet for this article.
March 2017: Oral Oncology
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