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Oral Oncology

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https://www.readbyqxmd.com/read/28202215/erratum-to-cytoreductive-surgery-for-head-and-neck-squamous-cell-carcinoma-in-the-new-age-of-immunotherapy-oral-oncol-61-2016-166-176
#1
R Bryan Bell, Michael J Gough, Steven K Seung, Zeljka Jutric, Andrew D Weinberg, Bernard A Fox, Marka R Crittenden, Rom S Leidner, Brendan Curti
No abstract text is available yet for this article.
February 12, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28089208/the-reconstructive-options-for-oropharyngeal-defects-in-the-transoral-robotic-surgery-framework
#2
Giuseppe Meccariello, Filippo Montevecchi, Rossella Sgarzani, Andrea De Vito, Giovanni D'Agostino, Riccardo Gobbi, Chiara Bellini, Claudio Vicini
Transoral robotic surgery (TORS) is a fascinating new technique that has been proved to be a safe and feasible for selected oropharyngeal cancers. Furthermore, TORS offers several advantages in the treatment of locoregionally advanced cancers. Nevertheless, the careful selection of patients is the keypoint for a successful application of this therapeutic modality. However, the reconstruction of large oropharyngeal defects is challenging due to the restoration of velopharyngeal competency and swallowing. Moreover, the absence of mandibular splitting increases the difficulties faced by reconstructive surgeons...
January 11, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28082058/the-importance-of-extranodal-extension-in-metastatic-head-and-neck-squamous-cell-carcinoma-in-the-light-of-the-new-ajcc-cancer-staging-system
#3
LETTER
Claudio Luchini, Nicola Veronese
No abstract text is available yet for this article.
January 9, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28012797/ataxia-telangiectasia-mutated-interactor-regulates-head-and-neck-cancer-metastasis-via-kras-expression
#4
Yue-Ju Li, Wei-Ting Lai, Cheng-Chi Chang, Mark Yen-Ping Kuo, Yi-Ting Deng, Cheng-Ning Yang, Shih-Jung Cheng, Tai-Sheng Wu, Szu-Ta Chen, Been-Ren Lin
OBJECTIVES: Relapse is the most serious problem affecting the morbidity and mortality rates of patients with head and neck squamous cell carcinoma (HNSCC). Although HNSCC has been studied for several decades, the exact mechanism of cancer recurrence remains unclear. MATERIALS AND METHODS: ataxia-telangiectasia mutated interactor (ATMIN) messenger RNA(mRNA) expression was detected in HNSCC samples by quantitative RT-PCR, and was analyzed with patients' clinical outcomes by Kaplan-Meier analyses...
December 21, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28109476/a-three-lncrna-signature-derived-from-the-atlas-of-ncrna-in-cancer-tanric-database-predicts-the-survival-of-patients-with-head-and-neck-squamous-cell-carcinoma
#5
Wei Cao, Jian-Nan Liu, Zeqi Liu, Xu Wang, Ze-Guang Han, Tong Ji, Wan-Tao Chen, Xin Zou
OBJECTIVE: Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). METHOD: We analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial least squares discrimination analysis (OPLS-DA) and 1.5-fold expression change criterion methods. The prognosis prediction model based on the lncRNA signatures and clinical parameters were evaluated using the 5-fold cross validation method...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109475/predictors-of-extracapsular-extension-in-hpv-associated-oropharyngeal-cancer-treated-surgically
#6
Mathew Geltzeiler, Daniel Clayburgh, John Gleysteen, Neil D Gross, Bronwyn Hamilton, Peter Andersen, Daniel Brickman
OBJECTIVES: Extracapsular extension (ECE) in cervical metastatic lymph nodes remains an indication for adding chemotherapy for patients with oropharyngeal squamous cell carcinoma (OPSCC). The aim of this study is to identify specific imaging characteristics on computed tomography (CT) scan that are predictive of ECE in order to better risk stratify patients preoperatively. MATERIALS AND METHODS: A single cohort study was performed using a prospectively collected database of patients with HPV-related OPSCC who underwent transoral robotic surgery with cervical lymphadenectomy...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109474/-hidden-scar-submandibular-gland-excision-using-an-endoscope-assisted-hairline-approach
#7
Seung Hoon Woo, Jung Je Park, MinSu Kwon, Jin Pyeong Kim
OBJECTIVES: Endoscope-assisted surgery is becoming the standard and most frequently preferred technique in a number of surgical disciplines because of its advantages of leaving a minimal or concealed postoperative scar compared with the conventional approaches. However, such operations are not yet standard in submandibular gland (SMG) surgery due to the anatomic complexity of this region. MATERIALS AND METHODS: We conducted a prospective comparative analysis of the clinical outcome of patients who underwent SMG resection using the hairline approach versus the conventional transcervical approach...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109473/competing-causes-of-death-in-the-head-and-neck-cancer-population
#8
Sean T Massa, Nosayaba Osazuwa-Peters, Kara M Christopher, Lauren D Arnold, Mario Schootman, Ronald J Walker, Mark A Varvares
PURPOSE/OBJECTIVES: The increasing survivorship of head and neck squamous cell carcinoma (HNSCC) comes with a risk of death from other causes, known as competing causes. The demographics of HNSCC are also evolving with increasing incidence of Human Papillomavirus (HPV) associated tumors. This study describes competing causes of death for the HNSCC population compared to the general population and identifies associated risk factors. METHODS: Adult patients with first mucosal HNSCC (2004-2011) were identified from the Surveillance, Epidemiology and End Result database...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109472/depression-and-survival-in-head-and-neck-cancer-patients
#9
Katherine Rieke, Kendra K Schmid, William Lydiatt, Julia Houfek, Eugene Boilesen, Shinobu Watanabe-Galloway
OBJECTIVE: Though depression often afflicts head and neck cancer (HNC) patients, few studies have examined the association between depression and survival in this particular cancer population. The objective of this study is to investigate the five-year survival of HNC patients by depression status. MATERIALS AND METHODS: This study used SEER-Medicare data from 2002-2010 and identified depression diagnosis two years before and one year after cancer diagnosis. HNC patients were identified using ICD-O3 codes and depression was identified using ICD-9-CM codes from Medicare claims...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109471/smoking-status-regulates-a-novel-panel-of-piwi-interacting-rnas-in-head-and-neck-squamous-cell-carcinoma
#10
Aswini R Krishnan, Avinaash Korrapati, Angela E Zou, Yuanhao Qu, Xiao Qi Wang, Joseph A Califano, Jessica Wang-Rodriguez, Scott M Lippman, Melbourne F Hovell, Weg M Ongkeko
OBJECTIVE: Smoking remains a primary etiological factor in head and neck squamous cell carcinoma (HNSCC). Given that non-coding RNAs (ncRNAs), including PIWI-interacting RNAs (piRNAs), have emerged as mediators of initiation and progression in head and neck malignancies, we undertook a global study of piRNA expression patterns in smoking-associated HNSCC. MATERIALS AND METHODS: Using RNA-sequencing data from 256 current smoker and lifelong nonsmoker samples in The Cancer Genome Atlas (TCGA), we analyzed the differential expression patterns of 27,127 piRNAs across patient cohorts stratified by tobacco use, with HPV16 status and tumor status taken into account...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109470/the-fate-of-the-free-flap-pedicle-after-free-tissue-transfer-to-the-head-and-neck-area
#11
Maarten L V Van Genechten, Martin D Batstone
OBJECTIVES: Little is understood about what happens to the vascular pedicle following free tissue transfer in the head and neck region. The viability of a free flap completely depends on the vascular supply by its vascular pedicle until neovascularization occurs from surrounding tissues. The aim of this study is to find out how long a vascular pedicle lasts following free tissue transfer in the head and neck region. MATERIALS AND METHODS: Patients were recruited from the Maxillofacial Unit at the Royal Brisbane & Women's Hospital...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109469/associations-between-neighbourhood-support-and-financial-burden-with-unmet-needs-of-head-and-neck-cancer-survivors
#12
Katie M O'Brien, Aileen Timmons, Phyllis Butow, Rachael Gooberman-Hill, Eleanor O'Sullivan, Myles Balfe, Linda Sharp
PURPOSE: To assess the unmet needs of head and neck cancer survivors and investigate associated factors. In particular, to explore whether social support (family/friends and neighbours) and financial burden are associated with unmet needs of head and neck cancer (HNC) survivors. METHODS: This was a cross-sectional study of HNC survivors, with 583 respondents included in the analysis. Information was collected on unmet supportive care needs as measured by the Supportive Care Needs Survey (SCNS-SF34)...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109468/preclinical-models-in-hnscc-a-comprehensive-review
#13
REVIEW
Benoite Méry, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Priscilla Battiston-Montagne, Dominique Ardail, Michael Beuve, Gersende Alphonse, Claire Rodriguez-Lafrasse, Nicolas Magné
Head and neck cancer remains a significant public health concern. About 60% of patients die within 5years due to local recurrence. Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for new therapies against this disease. Furthermore, there is a need to test novel drugs before introduction into clinical practice. A preclinical model that closely resembles the in vivo situation would be highly valuable. In the last few decades, a multicellular spheroid model has gained attention as its behavior was comparable to in vivo tumors...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109467/dexamethasone-in-head-and-neck-cancer-patients-with-microvascular-reconstruction-no-benefit-more-complications
#14
S Kainulainen, J Törnwall, A M Koivusalo, A L Suominen, P Lassus
OBJECTIVES: Glucocorticoids are widely used in association with major surgery of the head and neck to improve postoperative rehabilitation, shorten intensive care unit and hospital stay, and reduce neck swelling. This study aimed to clarify whether peri- and postoperative use of dexamethasone in reconstructive head and neck cancer surgery is associated with any advantages or disadvantages. MATERIALS AND METHODS: This prospective double-blind randomized controlled trial comprised 93 patients...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109466/definitive-proton-beam-therapy-for-adenoid-cystic-carcinoma-of-the-nasopharynx-involving-the-base-of-skull
#15
Michelle S Gentile, Darwin Yip, Norbert J Liebsch, Judith A Adams, Paul M Busse, Annie W Chan
OBJECTIVES: Management of unresectable adenocystic carcinoma (ACC) of the nasopharynx is challenging given the high dose required for tumor control while respecting dose constraints. We evaluated long-term outcomes and toxicity in patients with unresectable ACC of the nasopharynx treated with definitive proton beam therapy. METHODS: Between 2000 and 2013, 14 patients with ACC of the nasopharynx were treated. Ninety-three percent had T4 disease. All had involvement of the skull base...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109465/racial-disparities-in-oropharyngeal-cancer-survival
#16
Uchechukwu C Megwalu, Yifei Ma
BACKGROUND: Oropharyngeal cancer is an important cause of mortality and morbidity. Several studies have revealed racial disparities in head and neck cancer outcomes. The goal of our study was to evaluate the impact of race on survival in patients with oropharyngeal cancer, using a large population-based cancer database. MATERIALS AND METHODS: This was a retrospective cohort study. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 Database of the National Cancer Institute...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109464/therapeutic-implication-of-mtorc2-in-oral-squamous-cell-carcinoma
#17
Tomofumi Naruse, Souichi Yanamoto, Kohei Okuyama, Kentaro Yamashita, Keisuke Omori, Yuji Nakao, Shin-Ichi Yamada, Masahiro Umeda
The aim of the present study was to clarify the association of mTORC2 expression with the cancer progression and the anti-tumor effects of Torin-1 alone and combined treatment with Cetuximab in OSCC cells. The expressions of Rictor and SGK1 were immunohistochemically evaluated and the relationships between the expressions of molecular markers and clinicopathological factors were determined. Moreover, OSCC cells were treated with Torin-1, Cetuximab or combined agents, and anti-tumor effects of OSCC cells were examined in vitro and in vivo...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109463/head-and-neck-sarcomas-a-single-institute-series
#18
Leandros-Vassilios Vassiliou, Bagrat Lalabekyan, Amrita Jay, Colin Liew, Jeremy Whelan, Laurence Newman, Nicholas Kalavrezos
BACKGROUND: Sarcomas are tumours of mesenchymal origin, accounting for 1% of all malignancies. METHODS: This is a retrospective analysis of 107 head and neck sarcoma cases, treated over a period of thirteen years. RESULTS: Fifty-four patients had with craniofacial bone sarcomas (BSs) (male: 33; female: 21) with high grade osteosarcoma being the most predominant type. The soft tissue sarcomas (STS) (53 patients; male: 28, female: 25) were histologically diverse with rhabdomyosarcomas and myxofibrosarcomas being the predominant types...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109462/can-ratio-of-the-biggest-tumor-diameter-to-total-tumor-diameter-be-a-new-parameter-in-the-differential-diagnosis-of-agressive-and-favorable-multifocal-papillary-thyroid-microcarcinoma
#19
Abbas Ali Tam, Didem Özdemir, Neslihan Çuhacı, Hüsniye Başer, Ahmet Dirikoç, Cevdet Aydın, Aylin Kılıç Yazgan, Reyhan Ersoy, Bekir Çakır
OBJECTIVES: In this study, we aimed to evaluate the usefulness of a new parameter -ratio of the biggest tumor diameter to total tumor diameter- for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC). MATERIALS AND METHODS: The diameter of the biggest tumor focus was taken as the primary tumor diameter. Total tumor diameter was calculated as the sum of the maximal diameter of each lesion. Ratio of primary tumor diameter to total tumor diameter was defined as tumor diameter ratio (TDR)...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28049614/carcinoma-of-buccal-mucosa-with-metastasis-to-thigh
#20
LETTER
Gunjan Agrawal, Ashutosh Gupta, Vivek Chaudhary
No abstract text is available yet for this article.
February 2017: Oral Oncology
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