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Oral Oncology

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https://www.readbyqxmd.com/read/28559098/oral-lichenoid-dysplasia-and-exophytic-oral-verrucous-hyperplasia-mythical-entities-of-oral-pathology
#1
LETTER
A Thirumal Raj
No abstract text is available yet for this article.
May 27, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28545992/incidence-and-impact-of-dihydropyrimidine-dehydrogenase-gene-mutation-on-neoadjuvant-chemotherapy-in-head-and-neck-cancers
#2
LETTER
Anuradha Chougule, Vijay M Patil, Vanita Noronha, Amit Joshi, Siddharth Turkkar, Arun Chandrasekharan, Nikhil Pande, Priyanka Bagayatkar, Kumar Prabhash
No abstract text is available yet for this article.
May 22, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28456478/why-are-we-still-unable-to-accurately-determine-the-malignant-potential-or-the-behavior-of-oral-mucosal-lesions
#3
EDITORIAL
Pelin Güneri, Joel B Epstein
No abstract text is available yet for this article.
April 26, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28456477/human-papillomavirus-associated-oropharyngeal-cancer-prioritizing-preventive-policies-in-males
#4
LETTER
J Smith Torres-Roman, Diego Azañedo, Eloy F Ruiz, José L Avilez, Germán Málaga, Claudia Machicado
No abstract text is available yet for this article.
April 26, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427762/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-2
#5
REVIEW
A Rueda, J Giralt, M Mañós, A Lozano, A Sistiaga, E García-Miragall, J Cacicedo, F Esteban, B Scola, J Contreras, A Ruiz, A Carral, G Sanchez-Aniceto, M Pastor, J J Herranz, M Bernal, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists have to deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427761/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-1
#6
REVIEW
M Mañós, J Giralt, A Rueda, J Cabrera, J Martinez-Trufero, J Marruecos, A Lopez-Pousa, J P Rodrigo, B Castelo, J Martínez-Galán, F Arias, M Chaves, J J Herranz, V Arrazubi, N Baste, A Castro, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists must deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427760/lateral-lymph-node-recurrence-after-total-thyroidectomy-and-central-neck-dissection-in-patients-with-papillary-thyroid-cancer-without-clinical-evidence-of-lateral-neck-metastasis-comment-on-data-sparsity
#7
LETTER
https://www.readbyqxmd.com/read/28622892/a-phase-ii-trial-of-induction-nab-paclitaxel-and-cisplatin-followed-by-concurrent-chemoradiotherapy-in-patients-with-locally-advanced-nasopharyngeal-carcinoma
#8
Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Qun Xiang, Xiang Guo, Xing Lv
OBJECTIVES: Nanoparticle albumin-bound paclitaxel (NAB-paclitaxel) was designed to avoid solvent-related toxicities, and improve anti-tumor efficacy via increasing paclitaxel's intratumoral concentration and its uptake by tumor cells. This trial aimed to determine the safety and efficacy of induction NAB-paclitaxel combined with cisplatin followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS: Patients with stage III-IVb NPC received NAB-paclitaxel (260mg/m(2)) combined with cisplatin (80mg/m(2)) intravenously on days 1 and 22, followed by cisplatin (80mg/m(2)) on days 43 and 64, concomitant with intensity-modulated radiation therapy...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622891/functional-and-cosmetic-outcomes-of-robot-assisted-neck-dissection-by-a-postauricular-facelift-approach-for-head-and-neck-cancer
#9
Yong Bae Ji, Chang Myeon Song, Hyang Sook Bang, Hae Jin Park, Ji Young Lee, Kyung Tae
OBJECTIVES: The purpose of this study was to compare the functional and cosmetic outcomes of robot-assisted neck dissection with those of conventional neck dissection. MATERIALS AND METHODS: We prospectively analyzed 113 patients with head and neck cancer who underwent unilateral neck dissection by a robot-assisted postauricular facelift approach (38 patients) or conventional trans-cervical approach (75 patients). Postoperative functional outcomes such as edema, sensory loss, pain, and fibrosis in the neck, and limitations of neck and shoulder motion, and cosmetic satisfaction scored by questionnaire were evaluated serially up to 1year postoperatively, and compared between the two groups...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#10
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622889/turning-the-tide-clinical-utility-of-pd-l1-expression-in-squamous-cell-carcinoma-of-the-head-and-neck
#11
REVIEW
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Wouter Huvenne, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey
The use of cytotoxic and/or targeted agents is the gold standard in first- and second-line treatment of metastatic head and neck cancer. Currently the focus of oncologic research is shifting to the implementation of immune checkpoint inhibitor regimens. Many trials are being performed evaluating the survival benefit of various PD-1/PD-L1 blocking antibodies in both solid and haematological malignancies. Also, evaluation of the predictive value of PD-L1 expression on tumour cells and immune cells is being explored...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622888/validation-of-the-pathological-classification-of-lymph-node-metastasis-for-head-and-neck-tumors-according-to-the-8th-edition-of-the-tnm-classification-of-malignant-tumors
#12
Jacinto García, Montserrat López, Laura López, Silvia Bagué, Esther Granell, Miquel Quer, Xavier León
OBJECTIVES: One of the main changes in the 8th edition of the TNM Classification for head and neck tumors is the inclusion of extracapsular spread (ECS) as a criterion for evaluating the regional extension, both clinical (cN) and pathological (pN). The objective of our study is to evaluate the prognostic capacity derived from the inclusion of the ECS in the pathological classification of head and neck squamous cell carcinoma (HNSCC) patients treated with a neck dissection, as established by the 8th edition TNM Classification...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622887/genetic-etiology-of-oral-cancer
#13
REVIEW
Johar Ali, Bibi Sabiha, Hanif Ullah Jan, Syed Adnan Haider, Abid Ali Khan, Saima S Ali
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It accounts for 2.5% of all new cancer cases and 1.9% of all cancer deaths annually. More than 90% of oral cancers (occurring in the mouth, lip, and tongue) are oral squamous cell carcinoma. The incidence rate of oral cancer varies widely throughout the world, with an evident prevalence in South Asian countries. This high incidence occurs in correlation with oral cancer-associated behaviors such as alcohol, tobacco use...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622886/five-year-outcomes-of-an-oropharynx-directed-treatment-approach-for-unknown-primary-of-the-head-and-neck
#14
Kenneth Shung Hu, Waleed Fouad Mourad, Mauricio E Gamez, Wilson Lin, Adam Saul Jacobson, Mark Stephen Persky, Mark L Urken, Bruce E Culliney, Zujun Li, Theresa Nguyen Tran, Stimson Pryor Schantz, Juskaran Chadha, Louis Benjamin Harrison
PURPOSE: Squamous cell carcinoma of unknown primary (SCCHNUP) is commonly treated with comprehensive radiation to the laryngopharynx and bilateral necks. In 1998, we established a departmental policy to treat SCCHNUP with radiation directed to the oropharynx and bilateral neck. METHODS: From 1998-2011, 60 patients were treated - N1: 18%, N2: 75% and N3: 7%. 82% underwent neck dissection. 55% received IMRT and 62% underwent concurrent chemoradiotherapy. RESULTS: At median follow-up of 54months, 5 patients failed regionally and 4 emerged with a primary (tongue base, hypopharynx and thoracic esophagus)...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622885/the-impact-of-prophylactic-external-carotid-artery-ligation-on-postoperative-bleeding-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma
#15
John Gleysteen, Scott Troob, Tyler Light, Daniel Brickman, Daniel Clayburgh, Peter Andersen, Neil Gross
BACKGROUND: Transoral robotic-assisted surgery (TORS) is increasingly utilized in the treatment of oropharyngeal squamous cell carcinoma (OPSCC). Postoperative bleeding is a significant and potentially fatal complication of TORS. Prophylactic ligation of ipsilateral external carotid artery (ECA) branches is a recognized strategy to reduce postoperative bleeding risk. We examined the incidence and sequelae of postoperative oropharyngeal bleeding with and without routine ECA ligation. METHODS: OPSCC patients treated with TORS between 2010 and 2015 with minimum 30days follow up were included...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559028/establishing-and-applying-nomograms-based-on-the-8th-edition-of-the-uicc-ajcc-staging-system-to-select-patients-with-nasopharyngeal-carcinoma-who-benefit-from-induction-chemotherapy-plus-concurrent-chemoradiotherapy
#16
Cheng Xu, Yu-Pei Chen, Xu Liu, Wen-Fei Li, Lei Chen, Yan-Ping Mao, Yuan Zhang, Rui Guo, Guan-Qun Zhou, Ling-Long Tang, Ai-Hua Lin, Ying Sun, Jun Ma
OBJECTIVES: The subgroups of patients with nasopharyngeal carcinoma (NPC) who benefit from induction chemotherapy plus concurrent chemoradiotherapy (IC+CCRT) remain unclear. MATERIALS AND METHODS: We established prognostic nomograms for overall survival (OS) and disease-free survival (DFS), and validated the nomograms in 1230 patients with NPC and subgroup of 923 patients with locoregionally advanced NPC (LANPC). Three well-matched risk groups (i.e., low, intermediate and high risk) were created via recursive partitioning and 1-to-1 propensity score matching; IC+CCRT was compared with CCRT in each risk group...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559027/small-cell-carcinoma-of-the-head-and-neck-an-analysis-of-the-national-cancer-database
#17
Kelli B Pointer, Huaising C Ko, Jeffrey V Brower, Matthew E Witek, Randall J Kimple, Ricardo V Lloyd, Paul M Harari, Andrew M Baschnagel
PURPOSE/OBJECTIVE(S): To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region. MATERIALS/METHODS: Patients from 2004 to 2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Multivariable analysis was used to identify predictors of survival. RESULTS: Among 347,252 head and neck patients a total of 1042 (0.3%) patients with small cell carcinoma were identified...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559026/promotion-of-oral-surgical-wound-healing-using-autologous-mucosal-cell-sheets
#18
Jong-Lyel Roh, Hyejin Jang, Jaewang Lee, Eun Hye Kim, Daiha Shin
OBJECTIVES: Severe oral mucosal and tissue defects can lead to pain, infection, and later undesirable healing of scarring and adhesion, resulting in a poor quality of life. In vitro-engineered oral mucosal equivalents for covering such defects are an alternative to avoiding the donor site morbidity of conventional skin or tissue grafts. We examined the efficacy of our newly developed three-dimensional mucosal cell sheets in an in vivo tongue wound model mimicking the surgical extirpation of tongue cancer...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559025/oncological-outcome-following-de-intensification-of-treatment-for-stage-i-and-ii-hpv-negative-oropharyngeal-cancers-with-transoral-robotic-surgery-tors-a-prospective-trial
#19
Surender Dabas, Karan Gupta, Reetesh Ranjan, Ashwani K Sharma, Himanshu Shukla, Anant Dinesh
OBJECTIVE: This prospective study aimed to see long-term oncological outcome of Transoral Robotic Surgery as single modality treatment for cT1-T2 N0 HPV negative oropharyngeal malignancies. METHOD: From March 2013 to October 2015, 57 patients with early stage oropharyngeal carcinoma underwent Transoral robotic surgery (TORS) with neck dissection using daVinci® Surgical system. Patients were evaluated for disease free survival, overall survival, locoregional and distant metastasis...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559024/prediction-of-distant-metastases-from-nasopharyngeal-carcinoma-improved-diagnostic-performance-of-mri-using-nodal-volume-in-n1-and-n2-stage-disease
#20
Qi-Yong Ai, Ann D King, Frankie K F Mo, Benjamin King Hong Law, Kunwar S Bhatia, Brigette B Ma, Darren M C Poon, Michael K M Kam
PURPOSE: To determine if the magnetic resonance imaging (MRI) of the head and neck can predict distant metastases (DM) from nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS: MRI examinations of 763 NPC patients were assessed for primary tumour stage (T), nodal stage (N), primary tumour volume (PTV) and total nodal volume (NV). The association between MRI and clinical parameters were examined in DM+ and DM- patients using logistic regression and for distant metastases free survival (DMFS) using cox regression...
June 2017: Oral Oncology
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