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Oral Oncology

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https://www.readbyqxmd.com/read/28427762/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-2
#1
REVIEW
A Rueda, J Giralt, M Mañós, A Lozano, A Sistiaga, E García-Miragall, J Cacicedo, F Esteban, B Scola, J Contreras, A Ruiz, A Carral, G González-Aniceto, M Pastor, J J Herranz, M Bernal, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists have to deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427761/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-1
#2
REVIEW
M Mañós, J Giralt, A Rueda, J Cabrera, J Martinez-Trufero, J Marruecos, A Lopez-Pousa, J P Rodrigo, B Castelo, J Martínez-Galán, F Arias, M Chaves, J J Herranz, V Arrazubi, N Baste, A Castro, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists must deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427760/lateral-lymph-node-recurrence-after-total-thyroidectomy-and-central-neck-dissection-in-patients-with-papillary-thyroid-cancer-without-clinical-evidence-of-lateral-neck-metastasis-comment-on-data-sparsity
#3
LETTER
https://www.readbyqxmd.com/read/28347701/long-term-response-in-patient-with-recurrent-oropharyngeal-carcinoma-treated-with-cetuximab-docetaxel-and-cisplatin-tpex-as-first-line-treatment-followed-by-cetuximab-maintenance
#4
LETTER
J Guigay, C Even, L Mayache-Badis, M Debbah, E Saada-Bouzid, Y Tao, F Deschamps, F Janot, N Lezghed, C Michel
BACKGROUND: Cetuximab, an anti-EGFR monoclonal antibody in combination with platinum and 5FU is the standard of care in first-line treatment of patients with recurrent head and neck squamous cell carcinoma (HNSCC), with an expected median outcome of 10months. For this population, development of efficacious and safer therapies is still needed. CASE REPORT: A 62-year-old male with a first recurrence of human papillomavirus positive stage IVA (T3N2bM0) adenocarcinoma of the glossotonsillar sulcus not amenable to locoregional curative treatment was offered chemotherapy as part of the TPEx clinical trial...
March 24, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28325631/new-concepts-of-personalized-therapy-in-salivary-gland-carcinomas
#5
REVIEW
Gunter Keller, Diana Steinmann, Alexander Quaas, Viktor Grünwald, Stefan Janssen, Kais Hussein
Salivary gland carcinomas are rare tumours and therapy strategies are less standardized than in lung, gastric or breast cancer. Therapy is based on surgery, but not all carcinomas are completely resectable, e.g. because carcinomas often show infiltration of nerves. For further therapy decision pathology is recommended, but evaluation of potential targets for personalized therapy is not part of the routine panel. Many salivary gland carcinomas can be resistant to radio- and/or chemotherapy, which limits therapeutic options...
March 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28254238/corrigendum-to-hidden-scar-submandibular-gland-excision-using-an-endoscope-assisted-hairline-approach-oral-oncol-65-2017-83-88
#6
Seung Hoon Woo, Jung Je Park, MinSu Kwon, Jin Pyeong Kim
No abstract text is available yet for this article.
February 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28222967/clinical-implications-of-microscopic-extrathyroidal-extension-in-patients-with-papillary-thyroid-carcinoma
#7
Ji Su Park, Jae Won Chang, Lihua Liu, Seung-Nam Jung, Bon Seok Koo
BACKGROUND: Extrathyroidal extension (ETE) is a poor prognostic factor in papillary thyroid carcinoma (PTC). However, the impact of the degree of ETE, especially microscopic ETE, has not been well established. The purpose of present study was to compare differences in clinicopathological characteristics and clinical outcomes according to the presence or extent of ETE. METHODS: Data from 381 patients who underwent total thyroidectomy with/without lymph node (LN) dissection for PTC between 2004 and 2010 were analyzed...
February 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28202215/erratum-to-cytoreductive-surgery-for-head-and-neck-squamous-cell-carcinoma-in-the-new-age-of-immunotherapy-oral-oncol-61-2016-166-176
#8
R Bryan Bell, Michael J Gough, Steven K Seung, Zeljka Jutric, Andrew D Weinberg, Bernard A Fox, Marka R Crittenden, Rom S Leidner, Brendan Curti
No abstract text is available yet for this article.
February 12, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438300/malignant-transformation-of-oral-lichen-planus-and-oral-lichenoid-lesions-a-meta-analysis-of-20095-patient-data
#9
REVIEW
Sana Maher Hasan Aghbari, Abdelrahman Ibrahim Abushouk, Attia Attia, Ahmed Elmaraezy, Amr Menshawy, Mohamed Shehata Ahmed, Basma Abdelaleem Elsaadany, Eman Magdy Ahmed
OBJECTIVES: For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: We searched Medline, Scopus, and Web of Knowledge for relevant observational studies...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438299/can-gene-editing-and-silencing-technologies-play-a-role-in-the-treatment-of-head-and-neck-cancer
#10
REVIEW
Mushfiq H Shaikh, Daniel T W Clarke, Newell W Johnson, Nigel A J McMillan
Conventional treatment strategies have done little to improve the prognosis or disease-free survival in head and neck cancer (HNC) patients. Recent progress in our understanding of molecular aspects of head and neck squamous cell carcinoma (HNSCC) has provided insights into the potential use of molecular targeted therapies in combination with current treatment strategies. Here we review the current understanding of treatment modalities for both HPV-positive and HPV-negative HNSCCs with the potential to use gene editing and silencing technologies therapeutically...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438298/intravoxel-incoherent-motion-magnetic-resonance-imaging-in-head-and-neck-cancer-a-systematic-review-of-the-diagnostic-and-prognostic-value
#11
REVIEW
Daniel P Noij, Roland M Martens, J Tim Marcus, Remco de Bree, C René Leemans, Jonas A Castelijns, Marcus C de Jong, Pim de Graaf
Intravoxel incoherent motion (IVIM) imaging is increasingly applied in the assessment of head and neck cancer (HNC). Our purpose was to determine the diagnostic and prognostic performance of IVIM in HNC by performing a critical review of the literature. Pubmed and EMBASE were searched until May 2016. Study and patients characteristics, imaging protocol and diagnostic or prognostic outcomes were extracted by 2 independent reviewers. The studied IVIM parameters were diffusion coefficient (D), pseudodiffusion coefficient (D∗), and perfusion fraction (f)...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438297/investigating-a-case-of-possible-field-cancerization-in-oral-squamous-cell-carcinoma-by-the-use-of-next-generation-sequencing
#12
Siavosh Tabatabaeifar, Martin J Larsen, Stine R Larsen, Torben A Kruse, Mads Thomassen, Jens A Sørensen
OBJECTIVES: Local recurrence and the development of second primary tumors (SPT) are important factors that can influence the survival rate of oral squamous cell carcinoma (OSCC) patients. We investigate the concept of field cancerization which proposes that normal tissue adjacent to the primary tumor harbor pre-neoplastic alterations that can lead to the development of local recurrence and SPTs. MATERIALS AND METHODS: To examine the concept of field cancerization, we applied whole-exome and targeted ultra-deep sequencing on 5 freshly frozen samples from a stage III OSCC patient from three tumor sites, lymph node metastasis and blood...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438296/discussing-hpv-with-oropharyngeal-cancer-patients-a-cross-sectional-survey-of-attitudes-in-health-professionals
#13
Rachael H Dodd, Alice S Forster, Jo Waller, Laura A V Marlow
BACKGROUND: Human papillomavirus (HPV) is now known to cause a significant proportion of head and neck cancers (HNC). Qualitative research has shown that some health professionals find it difficult to discuss HPV with patients due to its sexually transmitted nature, and have concerns about their own knowledge of the virus. We used a survey to quantify attitudes towards discussing HPV among HNC health professionals. METHODS: We carried out a cross-sectional survey of HNC health professionals (n=260) in the UK and Ireland, assessing participants' knowledge of HPV, their experiences of and attitudes towards discussing HPV with patients, and their willingness to discuss HPV with their patients in the future...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#14
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438294/a-model-using-concomitant-markers-for-predicting-outcome-in-human-papillomavirus-positive-oropharyngeal-cancer
#15
Cinzia Bersani, Michael Mints, Nikolaos Tertipis, Linnea Haeggblom, Lars Sivars, Andreas Ährlund-Richter, Andrea Vlastos, Cecilia Smedberg, Nathalie Grün, Eva Munck-Wikland, Anders Näsman, Torbjörn Ramqvist, Tina Dalianis
OBJECTIVE: Head-neck cancer therapy has become intensified. With radiotherapy alone, 3-year disease-free survival (DFS) is 80% for HPV-positive TSCC/BOTSCC and better for patients with favorable characteristics, suggesting therapy could be tapered for some, decreasing side-effects. Therefore, we built a model to predict progression-free survival for patients with HPV-positive TSCC and BOTSCC. MATERIAL AND METHODS: TSCC/BOTSCC patients treated curatively between 2000 and 2011, with HPV16 DNA/E7 mRNA positive tumors examined for CD8(+) TILs, HPV16 mRNA and HLA class I expression were included...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438293/extrathyroidal-extension-what-does-it-mean
#16
REVIEW
Ashok R Shaha
Prognostic factors and risk group analysis are very well known in well differentiated thyroid cancer. One of the major prognostic factors is presence of extrathyroidal extension and residual gross tumor. It is not uncommon to find the final pathology report showing minimal extrathyroidal extension. The debate continues as to the implication of this microscopic or minimal extrathyroidal extension. The previous staging system had upstaged such tumors. However, several reports in the literature suggest no prognostic implication of microscopic or minimal extrathyroidal extension...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438292/correlation-of-crtc1-3-maml2-fusion-status-grade-and-survival-in-mucoepidermoid-carcinoma
#17
Andrew C Birkeland, Susan K Foltin, Nicole L Michmerhuizen, Rebecca C Hoesli, Andrew J Rosko, Serena Byrd, Megan Yanik, Jacques E Nor, Carol R Bradford, Mark E Prince, Thomas E Carey, Jonathan B McHugh, Matthew E Spector, J Chad Brenner
OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Tumor stage and grade have historically been important predictors of survival. An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs. Historically, these gene fusions have been associated with lower grade tumors and better survival. However, reported gene fusion rates and prognosis varies widely across studies, and have not controlled for tumor grade. We sought to identify gene fusion rates and outcomes in our cohort of MEC patients...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438291/radiation-induced-hypothyroidism-after-imrt-for-nasopharyngeal-carcinoma-clinical-and-dosimetric-predictors-in-a-prospective-cohort-study
#18
Rui-Ping Zhai, Fang-Fang Kong, Cheng-Run Du, Chao-Su Hu, Hong-Mei Ying
OBJECTIVES: To investigate the rate and risk factors for developing hypothyroidism (HT) in nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: A total of 135 consecutive patients treated with IMRT for NPC were prospectively evaluated during a median follow up of 34.1months. Serum thyroid function assessments before and after IMRT were periodically monitored. To identify risk factors for HT occurrence, univariate and multivariate Cox regression analyses were performed...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438290/programmed-death-ligand-1-pd-l1-expression-and-tumor-microenvironment-implications-for-patients-with-oral-precancerous-lesions
#19
Takahiro Yagyuu, Kinta Hatakeyama, Mitsuhiko Imada, Miyako Kurihara, Yumiko Matsusue, Kazuhiko Yamamoto, Chiho Obayashi, Tadaaki Kirita
OBJECTIVES: Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transformation of oral precancerous lesions. MATERIALS AND METHODS: Patients with oral precancerous lesions managed at the Nara Medical University Hospital, Japan, (n=120) were enrolled in this study...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438289/impact-of-fraction-size-on-locally-advanced-oropharyngeal-and-nasopharyngeal-cancers-treated-with-chemoradiation
#20
Michael T Spiotto, Matthew Koshy
OBJECTIVES: Although chemoradiation regimens have used various fraction sizes, it remains unclear how differences in fraction size impact outcomes. MATERIALS AND METHODS: Using the National Cancer Database, we identified patients with nasopharynx or oropharynx cancers treated between 2004 and 2012 with chemoradiation using fraction sizes of 1.8Gy (n=1612), 2Gy (n=8092) or 2.12Gy (n=1660). Comparisons between fraction sizes were made in the entire cohort and in a propensity matched cohort...
May 2017: Oral Oncology
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