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Depression and Anxiety

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https://www.readbyqxmd.com/read/28504861/the-efficacy-of-benzodiazepines-as-acute-anxiolytics-in-children-a-meta-analysis
#1
Heide Kuang, Jessica A Johnson, Jilian M Mulqueen, Michael H Bloch
OBJECTIVE: Current practice guidelines do not recommend benzodiazepines for acute management of anxiety disorders in pediatric patients. However, in procedural settings, benzodiazepines are commonly used to relieve acute preprocedural stress. This meta-analysis examines the efficacy and tolerability of benzodiazepines as short-term anxiolytics in children. METHOD: PubMed was searched for randomized controlled trials assessing the efficacy of benzodiazepines as short-term anxiolytics in pediatric patients...
May 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28504859/anxiety-there-is-an-app-for-that-a-systematic-review-of-anxiety-apps
#2
REVIEW
Madalina Sucala, Pim Cuijpers, Frederick Muench, Roxana Cardoș, Radu Soflau, Anca Dobrean, Patriciu Achimas-Cadariu, Daniel David
BACKGROUND: Smartphones and mobile devices have become ubiquitous, and with the rapid advance of technology, the number of health applications (apps) that are available for consumers on these devices is constantly growing. In particular, there has been a recent proliferation of anxiety apps. However, there has been no review of the quality or content of these anxiety apps and little is known about their purpose, the features they contain, and their empirical support. The goal of this systematic review was to assess the commercially available anxiety apps...
May 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28499066/perceiving-social-pressure-not-to-feel-negative-predicts-depressive-symptoms-in-daily-life
#3
Egon Dejonckheere, Brock Bastian, Eiko I Fried, Sean C Murphy, Peter Kuppens
BACKGROUND: Western societies often overemphasize the pursuit of happiness, and regard negative feelings such as sadness or anxiety as maladaptive and unwanted. Despite this emphasis on happiness, the amount of people suffering from depressive complaints is remarkably high. To explain this apparent paradox, we examined whether experiencing social pressure not to feel sad or anxious could in fact contribute to depressive symptoms. METHODS: A sample of individuals (n = 112) with elevated depression scores (Patient Health Questionnaire [PHQ-9] ≥ 10) took part in an online daily diary study in which they rated their depressive symptoms and perceived social pressure not to feel depressed or anxious for 30 consecutive days...
May 12, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28494123/ecological-momentary-interventions-for-depression-and-anxiety
#4
Stephen M Schueller, Adrian Aguilera, David C Mohr
Ecological momentary interventions (EMIs) are becoming more popular and more powerful resources for the treatment and prevention of depression and anxiety due to advances in technological capacity and analytic sophistication. Previous work has demonstrated that EMIs can be effective at reducing symptoms of depression and anxiety as well as related outcomes of stress and at increasing positive psychological functioning. In this review, we highlight the differences between EMIs and other forms of treatment due to the nature of EMIs to be deeply integrated into the fabric of people's day-to-day lives...
May 11, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28494120/posttraumatic-stress-disorder-symptom-severity-is-associated-with-reduced-default-mode-network-connectivity-in-individuals-with-elevated-genetic-risk-for-psychopathology
#5
Danielle R Miller, Mark W Logue, Erika J Wolf, Hannah Maniates, Meghan E Robinson, Jasmeet P Hayes, Annjanette Stone, Steven Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship between DMN connectivity and PTSD. In this study, we investigated this possibility using genome-wide association study (GWAS) derived polygenic risk scores (PRSs) for relevant psychiatric traits...
May 11, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489327/new-directions-for-the-treatment-of-depression-targeting-the-photic-regulation-of-arousal-and-mood-pram-pathway
#6
REVIEW
Hannah E Bowrey, Morgan H James, Gary Aston-Jones
Both preclinical and clinical studies demonstrate that depression is strongly associated with reduced light availability, which in turn contributes to decreased function of brain regions that control mood. Here, we review findings that support a critical pathway for the control of mood that depends upon ambient light. We put forward a novel hypothesis, functionally linking retina to locus coeruleus (LC) in depression, and discuss the role of norepinephrine in affective disease. Finally, we discuss how utilizing the chemogenetic tool Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to precisely control this retina-LC circuit may be used as a novel therapeutic to treat depression...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489321/nicotine-deprivation-attenuates-panic-reactivity-in-smokers-findings-from-a-placebo-controlled-nicotine-patch-study
#7
Kenneth Abrams, Sam Krimmel, Stacey Johnson, Kate Cieslowski, Helen Strnad, Arielle Melum, Caroline Kryder
BACKGROUND: Prospective studies consistently find that smoking is a risk factor for the development of panic disorder (PD). A possible explanation is that nicotine deprivation promotes heightened sensitivity to bodily sensations and/or arterial carbon dioxide (CO2 ). Abrams et al. (2011) previously found that, in response to a CO2 rebreathing challenge, smokers experiencing more (vs. less) intense nicotine withdrawal had more severe panic symptoms and a stronger urge to escape. However, participants were aware of the last time they smoked, leaving unclear the extent to which fear reactivity was influenced by the pharmacologic effects of nicotine deprivation versus beliefs regarding when nicotine was most recently used...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489319/low-physical-activity-as-a-key-differentiating-factor-in-the-potential-high-risk-profile-for-depressive-symptoms-in-older-adults
#8
Sofie Holmquist, Sabina Mattsson, Ingrid Schele, Peter Nordström, Anna Nordström
BACKGROUND: The identification of potential high-risk groups for depression is of importance. The purpose of the present study was to identify high-risk profiles for depressive symptoms in older individuals, with a focus on functional performance. METHODS: The population-based Healthy Ageing Initiative included 2,084 community-dwelling individuals (49% women) aged 70. Explorative cluster analysis was used to group participants according to functional performance level, using measures of basic mobility skills, gait variability, and grip strength...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489300/predictors-of-ptsd-40-years-after-combat-findings-from-the-national-vietnam-veterans-longitudinal-study
#9
Maria M Steenkamp, William E Schlenger, Nida Corry, Clare Henn-Haase, Meng Qian, Meng Li, Danny Horesh, Karen-Inge Karstoft, Christianna Williams, Chia-Lin Ho, Arieh Shalev, Richard Kulka, Charles Marmar
BACKGROUND: Few studies have longitudinally examined predictors of posttraumatic stress disorder (PTSD) in a nationally representative sample of US veterans. We examined predictors of warzone-related PTSD over a 25-year span using data from the National Vietnam Veterans Longitudinal Study (NVVLS). METHODS: The NVVLS is a follow-up study of Vietnam theater veterans (N = 699) previously assessed in the National Vietnam Veterans Readjustment Study (NVVRS), a large national-probability study conducted in the late 1980s...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489293/the-role-of-family-history-of-depression-and-the-menopausal-transition-in-the-development-of-major-depression-in-midlife-women-study-of-women-s-health-across-the-nation-mental-health-study-swan-mhs
#10
Alicia Colvin, Gale A Richardson, Jill M Cyranowski, Ada Youk, Joyce T Bromberger
BACKGROUND: This study evaluated whether family history of depression predicts major depression in midlife women above and beyond static risk factors (such as personal history of depression prior to midlife) and risks that may change dynamically across midlife (such as menopausal, psychosocial, and health profiles). METHODS: Participants were 303 African American and Caucasian women (42-52 years at baseline) recruited into the Study of Women's Health across the Nation (SWAN) Mental Health Study (MHS) in Pittsburgh...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28489272/fear-learning-alterations-after-traumatic-brain-injury-and-their-role-in-development-of-posttraumatic-stress-symptoms
#11
Daniel E Glenn, Dean T Acheson, Mark A Geyer, Caroline M Nievergelt, Dewleen G Baker, Victoria B Risbrough
BACKGROUND: It is unknown how traumatic brain injury (TBI) increases risk for posttraumatic stress disorder (PTSD). One potential mechanism is via alteration of fear-learning processes that could affect responses to trauma memories and cues. We utilized a prospective, longitudinal design to determine if TBI is associated with altered fear learning and extinction, and if fear processing mediates effects of TBI on PTSD symptom change. METHODS: Eight hundred fifty two active-duty Marines and Navy Corpsmen were assessed before and after deployment...
May 10, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28471534/predicting-suicide-with-the-sad-persons-scale
#12
Cara Katz, Jason R Randall, Jitender Sareen, Dan Chateau, Randy Walld, William D Leslie, JianLi Wang, James M Bolton
BACKGROUND: Suicide is a major public health issue, and a priority requirement is accurately identifying high-risk individuals. The SAD PERSONS suicide risk assessment scale is widely implemented in clinical settings despite limited supporting evidence. This article aims to determine the ability of the SAD PERSONS scale (SPS) to predict future suicide in the emergency department. METHODS: Five thousand four hundred sixty-two consecutive adults were seen by psychiatry consultation teams in two tertiary emergency departments with linkage to population-based administrative data to determine suicide deaths within 6 months, 1, and 5 years...
May 4, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28471488/maternal-choline-status-during-pregnancy-but-not-that-of-betaine-is-related-to-antenatal-mental-well-being-the-growing-up-in-singapore-toward-healthy-outcomes-cohort
#13
Linde van Lee, Phaik Ling Quah, Seang Mei Saw, Fabian K P Yap, Keith M Godfrey, Yap Seng Chong, Michael J Meaney, Helen Chen, Mary Foong-Fong Chong
BACKGROUND: Choline and betaine status have previously been associated with symptoms of depression. However, the relation of maternal plasma choline and betaine concentrations in pregnancy to peripartum maternal mood is unknown. METHODS: Maternal plasma choline and betaine concentrations (μmol/L) were measured at 26-28 weeks gestation in the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. Participants completed the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EDPS) at 26-28 weeks gestation (n = 949) and at 3 months postnatal (n = 689): higher scores are indicative of more symptoms of anxiety and depression...
May 4, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28471479/internet-and-mobile-interventions-for-depression-opportunities-and-challenges
#14
REVIEW
Pim Cuijpers, Annet Kleiboer, Eirini Karyotaki, Heleen Riper
BACKGROUND: The Internet offers several new ways of developing, implementing, and disseminating evidence-based interventions for depression. METHODS: In this paper, we narratively synthesized the evidence showing that Internet-based therapies are effective in treating depression. RESULTS: In the past decade, a considerable number of psychological treatments have been developed for the treatment of depression and several hundreds of randomized controlled trials have been conducted, showing that these interventions are effective and that there are no major differences in effects between therapies...
May 4, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453916/digital-technology-and-clinical-decision-making-in-depression-treatment-current-findings-and-future-opportunities
#15
REVIEW
Kevin A Hallgren, Amy M Bauer, David C Atkins
Clinical decision making encompasses a broad set of processes that contribute to the effectiveness of depression treatments. There is emerging interest in using digital technologies to support effective and efficient clinical decision making. In this paper, we provide "snapshots" of research and current directions on ways that digital technologies can support clinical decision making in depression treatment. Practical facets of clinical decision making are reviewed, then research, design, and implementation opportunities where technology can potentially enhance clinical decision making are outlined...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453905/transdiagnostic-neural-correlates-of-affective-face-processing-in-anxiety-and-depression
#16
Annmarie MacNamara, Heide Klumpp, Amy E Kennedy, Scott A Langenecker, K Luan Phan
BACKGROUND: It is unknown whether there are neurobiologic differences between various anxiety and depressive disorders, or whether they are characterized by shared neurobiologic variation that cuts across diagnostic boundaries. For instance, multiple anxiety disorders and depression may be characterized by abnormalities in blood oxygen-level dependent (BOLD) response during the processing of affective scenes and faces. To interrogate the shared or unique nature of these aberrations, research that examines the influence of transdiagnostic, dimensional predictors across multiple diagnoses is needed...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453890/less-is-more-patient-level-meta-analysis-reveals-paradoxical-dose-response-effects-of-a-computer-based-social-anxiety-intervention-targeting-attentional-bias
#17
REVIEW
Rebecca B Price, Jennie M Kuckertz, Nader Amir, Yair Bar-Haim, Per Carlbring, Meredith L Wallace
BACKGROUND: The past decade of research has seen considerable interest in computer-based approaches designed to directly target cognitive mechanisms of anxiety, such as attention bias modification (ABM). METHODS: By pooling patient-level datasets from randomized controlled trials of ABM that utilized a dot-probe training procedure, we assessed the impact of training "dose" on relevant outcomes among a pooled sample of 693 socially anxious adults. RESULTS: A paradoxical effect of the number of training trials administered was observed for both posttraining social anxiety symptoms and behavioral attentional bias (AB) toward threat (the target mechanism of ABM)...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28440902/between-visit-changes-in-suicidal-ideation-and-risk-of-subsequent-suicide-attempt
#18
Gregory E Simon, Susan M Shortreed, Eric Johnson, Arne Beck, Karen J Coleman, Rebecca C Rossom, Ursula S Whiteside, Belinda H Operskalski, Robert B Penfold
BACKGROUND: While clinicians are expected to routinely assess and address suicide risk, existing data provide little guidance regarding the significance of visit-to-visit changes in suicidal ideation. METHODS: Electronic health records from four large healthcare systems identified patients completing the Patient Health Questionnaire or PHQ9 at outpatient visits. For patients completing two questionnaires within 90 days, health system records and state vital records were used to identify nonfatal and fatal suicide attempts...
April 25, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28426908/clinically-useful-brain-imaging-for-neuropsychiatry-how-can-we-get-there
#19
REVIEW
Michael P Milham, R Cameron Craddock, Arno Klein
Despite decades of research, visions of transforming neuropsychiatry through the development of brain imaging-based "growth charts" or "lab tests" have remained out of reach. In recent years, there is renewed enthusiasm about the prospect of achieving clinically useful tools capable of aiding the diagnosis and management of neuropsychiatric disorders. The present work explores the basis for this enthusiasm. We assert that there is no single advance that currently has the potential to drive the field of clinical brain imaging forward...
April 20, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28419625/meta-analysis-of-interventions-for-posttraumatic-stress-disorder-and-depression-in-adult-survivors-of-mass-violence-in-low-and-middle-income-countries
#20
REVIEW
Nexhmedin Morina, Mina Malek, Angela Nickerson, Richard A Bryant
BACKGROUND: Most survivors of mass violence live in low- and middle-income countries (LMICs). We conducted a meta-analysis of randomized controlled psychotherapy trials for adult posttraumatic stress disorder (PTSD) and/or depression in LMICs. METHODS: We included 18 clinical trials (3,058 participants), in which 25 and 18 treatment arms measured symptoms of PTSD and depression, respectively. RESULTS: Active treatments for PTSD yielded a large aggregated pre-post effect size (g = 1...
April 18, 2017: Depression and Anxiety
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