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Depression and Anxiety

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https://www.readbyqxmd.com/read/29451967/cognitive-behavioral-therapy-for-anxiety-and-related-disorders-a-meta-analysis-of-randomized-placebo-controlled-trials
#1
REVIEW
Joseph K Carpenter, Leigh A Andrews, Sara M Witcraft, Mark B Powers, Jasper A J Smits, Stefan G Hofmann
The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings demonstrated moderate placebo-controlled effects of CBT on target disorder symptoms (Hedges' g = 0...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451956/posttraumatic-stress-disorder-ptsd-and-complex-ptsd-cptsd-as-per-icd-11-proposals-a-population-study-in-israel
#2
Menachem Ben-Ezra, Thanos Karatzias, Philip Hyland, Chris R Brewin, Marylene Cloitre, Jonathan I Bisson, Neil P Roberts, Brigitte Lueger-Schuster, Mark Shevlin
BACKGROUND: The current study sought to advance the existing literature by providing the first assessment of the factorial and discriminant validity of the ICD-11 proposals for posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) in a nationwide level. METHODS: A nationally representative sample from Israel (n = 1,003) using a disorder-specific measure (ITQ; International Trauma Questionnaire) in order to assess PTSD and CPTSD along with the Life Events Checklist and the World Health Organization Well-Being Index...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451948/duration-of-maternal-mental-health-related-outcomes-after-an-infant-s-death-a-retrospective-matched-cohort-study-using-linkable-administrative-data
#3
Elizabeth Wall-Wieler, Leslie L Roos, James Bolton
BACKGROUND: Mothers have increased mental illness such as anxiety and depression after the death of a child. We examine the duration of this worsening of mental health. METHODS: The mental health of all mothers who experience the death of an infant (< 1 years old) in Manitoba, Canada between April 1, 1999 and March 31, 2011 (n = 534) is examined in the 4 years leading up to, and the 4 years following, the death of their child. Mental health-related outcomes of these mothers are compared with a matched (3:1) cohort of mothers who did not experience the death of a child (n = 1,602)...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29421842/early-psychological-impact-of-paris-terrorist-attacks-on-healthcare-emergency-staff-a-cross-sectional-study
#4
Carla De Stefano, Massimiliano Orri, Jean Marc Agostinucci, Haroun Zouaghi, Frederic Lapostolle, Thierry Baubet, Frederic Adnet
BACKGROUND: The terrorist attacks in Paris and Saint Denis on November 13, 2015 were an unprecedented traumatic event in France. It was an especially distressing ordeal for the healthcare personnel involved in the care of the victims. The aim of this study was to estimate the effect of direct participation in the rescue on posttraumatic stress disorder (PTSD) symptoms among these workers. METHODS: Less than a month later, 613 healthcare providers (professionals and paraprofessionals) from three hospitals in the Paris suburbs were asked to complete an anonymous questionnaire...
February 8, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29394520/prenatal-exposure-to-maternal-and-paternal-depressive-symptoms-and-white-matter-microstructure-in-children
#5
Hanan El Marroun, Runyu Zou, Ryan L Muetzel, Vincent W Jaddoe, Frank C Verhulst, Tonya White, Henning Tiemeier
BACKGROUND: Prenatal maternal depression has been associated with multiple problems in offspring involving affect, cognition, and neuroendocrine functioning. This suggests that prenatal depression influences neurodevelopment. However, the underlying neurodevelopmental mechanism remains unclear. We prospectively assessed whether maternal depressive symptoms during pregnancy and at the child's age 3 years are related to white matter microstructure in 690 children. The association of paternal depressive symptoms with childhood white matter microstructure was assessed to evaluate genetic or familial confounding...
February 2, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29394511/behavioral-avoidance-predicts-treatment-outcome-with-exposure-and-response-prevention-for-obsessive-compulsive-disorder
#6
Michael G Wheaton, Marina Gershkovich, Thea Gallagher, Edna B Foa, H Blair Simpson
BACKGROUND: Many individuals with obsessive-compulsive disorder (OCD) display behavioral avoidance related to their obsessional thoughts and compulsive behaviors. However, how these avoidance behaviors impact treatment outcomes with exposure and response prevention (EX/RP) remains unclear. We examined pretreatment avoidance behaviors as predictors of EX/RP outcomes. METHODS: Data came from a randomized controlled trial of augmentation strategies for inadequate response to serotonin reuptake inhibitors comparing EX/RP (N = 40), risperidone (N = 40), and placebo (N = 20)...
February 2, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29394510/a-longitudinal-study-of-women-s-depression-symptom-profiles-during-and-after-the-postpartum-phase
#7
Molly Fox, Curt A Sandman, Elysia Poggi Davis, Laura M Glynn
BACKGROUND: An issue of critical importance for psychiatry and women's health is whether postpartum depression (PPD) represents a unique condition. The Diagnostic and Statistical Manual of Mental Disorders asserts that major depressive disorder (MDD) may present with peripartum onset, without suggesting any other differences between MDD and PPD. The absence of any distinct features calls into question the nosologic validity of PPD as a diagnostic category. The present study investigates whether symptom profiles differ between PPD and depression occurring outside the postpartum phase...
February 2, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29365217/will-imaging-individual-raphe-nuclei-in-males-with-major-depressive-disorder-enhance-diagnostic-sensitivity-and-specificity
#8
Rajapillai L I Pillai, Mengru Zhang, Jie Yang, Maura Boldrini, J John Mann, Maria A Oquendo, Ramin V Parsey, Christine DeLorenzo
BACKGROUND: Positron emission tomography (PET) studies in major depressive disorder (MDD) have reported higher serotonin 1A (5-HT1A ) autoreceptor binding in the raphe. In males, the difference is so large that it can potentially be used as the first biological marker for MDD. However, the raphe includes several nuclei, which project to different regions of the brain and spinal cord and may be differentially involved in disease. We aimed to identify 5-HT1A differences in individual raphe nuclei using PET in order to determine whether use of subnuclei would provide greater sensitivity and specificity of diagnosing MDD...
January 24, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29356216/treatment-gap-for-anxiety-disorders-is-global-results-of-the-world-mental-health-surveys-in-21-countries
#9
Jordi Alonso, Zhaorui Liu, Sara Evans-Lacko, Ekaterina Sadikova, Nancy Sampson, Somnath Chatterji, Jibril Abdulmalik, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Laura H Andrade, Ronny Bruffaerts, Graça Cardoso, Alfredo Cia, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Josep M Haro, Yanling He, Peter de Jonge, Elie G Karam, Norito Kawakami, Viviane Kovess-Masfety, Sing Lee, Daphna Levinson, Maria Elena Medina-Mora, Fernando Navarro-Mateu, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Margreet Ten Have, Zahari Zarkov, Ronald C Kessler, Graham Thornicroft
BACKGROUND: Anxiety disorders are a major cause of burden of disease. Treatment gaps have been described, but a worldwide evaluation is lacking. We estimated, among individuals with a 12-month DSM-IV (where DSM is Diagnostic Statistical Manual) anxiety disorder in 21 countries, the proportion who (i) perceived a need for treatment; (ii) received any treatment; and (iii) received possibly adequate treatment. METHODS: Data from 23 community surveys in 21 countries of the World Mental Health (WMH) surveys...
January 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29329499/a-pilot-study-of-the-comparative-efficacy-of-100%C3%A2-hz-magnetic-seizure-therapy-and-electroconvulsive-therapy-in-persistent-depression
#10
Paul B Fitzgerald, Kate E Hoy, David Elliot, Susan McQueen, Lenore E Wambeek, Leo Chen, Anne Maree Clinton, Glenn Downey, Zafiris J Daskalakis
BACKGROUND: Magnetic seizure therapy (MST) is a novel brain stimulation technique that uses a high-powered transcranial magnetic stimulation device to produce therapeutic seizures. Preliminary MST studies have found antidepressant effects in the absence of cognitive side effects but its efficacy compared to electroconvulsive therapy (ECT) remains unclear. The aim of this study was to investigate the therapeutic efficacy and cognitive profile of MST compared to standard right unilateral ECT treatment...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29329498/treatment-outcomes-of-acute-bipolar-depressive-episode-with-psychosis
#11
Marco Antonio Caldieraro, Steven Dufour, Louisa G Sylvia, Keming Gao, Terence A Ketter, William V Bobo, Samantha Walsh, Jessica Janos, Mauricio Tohen, Noreen A Reilly-Harrington, Susan L McElroy, Richard C Shelton, Charles L Bowden, Thilo Deckersbach, Andrew A Nierenberg
BACKGROUND: The impact of psychosis on the treatment of bipolar depression is remarkably understudied. The primary aim of this study was to compare treatment outcomes of bipolar depressed individuals with and without psychosis. The secondary aim was to compare the effect of lithium and quetiapine, each with adjunctive personalized treatments (APTs), in the psychotic subgroup. METHODS: We assessed participants with DSM-IV bipolar depression included in a comparative effectiveness study of lithium and quetiapine with APTs (the Bipolar CHOICE study)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29329486/cost-effectiveness-of-guided-internet-based-interventions-for-depression-in-comparison-with-control-conditions-an-individual-participant-data-meta-analysis
#12
REVIEW
Spyros Kolovos, Johanna M van Dongen, Heleen Riper, Claudia Buntrock, Pim Cuijpers, David D Ebert, Anna S Geraedts, Robin M Kenter, Stephanie Nobis, Andrea Smith, Lisanne Warmerdam, Jill A Hayden, Maurits W van Tulder, Judith E Bosmans
BACKGROUND: There is limited evidence on the cost effectiveness of Internet-based treatments for depression. The aim was to evaluate the cost effectiveness of guided Internet-based interventions for depression compared to controls. METHODS: Individual-participant data from five randomized controlled trials (RCT), including 1,426 participants, were combined. Cost-effectiveness analyses were conducted at 8 weeks, 6 months, and 12 months follow-up. RESULTS: The guided Internet-based interventions were more costly than the controls, but not statistically significant (12 months mean difference = €406, 95% CI: - 611 to 1,444)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29283198/a-classical-twin-study-of-ptsd-symptoms-and-resilience-evidence-for-a-single-spectrum-of-vulnerability-to-traumatic-stress
#13
Erika J Wolf, Mark W Miller, Danielle R Sullivan, Ananda B Amstadter, Karen S Mitchell, Jack Goldberg, Kathryn M Magruder
BACKGROUND: To examine shared genetic and environmental risk factors across PTSD symptoms and resilience. METHODS: Classical twin study of 2010-2012 survey data conducted among 3,318 male twin pairs in the Vietnam Era Twin Registry. Analyses included: (a) estimates of genetic and environmental influences on PTSD symptom severity (as measured by the PTSD Checklist) and resilience (assessed with the Connor-Davidson Resilience Scale-10); (b) development of a latent model of traumatic stress, spanning both PTSD and resilience; and (c) estimates of genetic and environmental influences on this spectrum...
December 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29267991/extraction-of-mean-emotional-tone-from-face-arrays-in-social-anxiety-disorder
#14
Zohar Z Bronfman, Noam Brezis, Amit Lazarov, Marius Usher, Yair Bar-Haim
BACKGROUND: Social anxiety disorder (SAD) is characterized by intense fear when facing a crowd. Processing biases of crowd-related information have been suggested as contributing to the etiology and maintenance of the disorder. Here we tested whether patients with SAD display aberrant patterns of extracting the mean emotional tone from sets of faces. METHODS: Twenty-one participants with SAD and 24 unanxious control participants had to determine the average emotion expression of sets of six different morphed faces ranging from happy to angry...
December 21, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244908/changes-in-coping-and-social-motives-for-drinking-and-alcohol-consumption-across-the-menstrual-cycle
#15
Kayla M Joyce, Amanda Hudson, Roisin O'Connor, Kara Thompson, Megan Hodgin, Tara Perrot, Sherry H Stewart
BACKGROUND: Alcohol use has been reported to fluctuate over women's menstrual cycles (MCs), with increased intake occurring premenstrually/menstrually (phases characterized by heightened negative affect) and during the ovulatory phase (a phase characterized by positive affect). This suggests women may drink for particular emotion-focused reasons at specific points in their cycles. However, no research had yet examined MC variability in drinking motives, or links between cycle-related changes in drinking motives and alcohol consumption...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244906/finding-treatment-resistant-depression-in-real-world-data-how-a-data-driven-approach-compares-with-expert-based-heuristics
#16
M Soledad Cepeda, Jenna Reps, Daniel Fife, Clair Blacketer, Paul Stang, Patrick Ryan
BACKGROUND: Depression that does not respond to antidepressants is treatment-resistant depression (TRD). TRD definitions include assessments of treatment response, dose and duration, and implementing these definitions in claims databases can be challenging. We built a data-driven TRD definition and evaluated its performance. METHODS: We included adults with depression, ≥1 antidepressant, and no diagnosis of mania, dementia, or psychosis. Subjects were stratified into those with and without proxy for TRD...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244901/trauma-exposure-and-undetected-posttraumatic-stress-disorder-among-adults-with-a-mental-disorder
#17
Catrin Lewis, Lawrence Raisanen, Jonathan I Bisson, Ian Jones, Stan Zammit
BACKGROUND: Trauma exposure and posttraumatic stress disorder (PTSD) are common among individuals with a mental disorder, but symptoms often go undetected and untreated. METHODS: The aim of this study was to determine the prevalence of PTSD among a large sample of adults with psychiatric diagnoses and to establish factors associated with symptoms going undetected. Participants were 1,946 adults recruited by the National Centre for Mental Health. Structured interviews and validated self-report questionnaires were used to ascertain clinical and demographic information for analysis...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244900/the-bidirectional-relationship-between-anxiety-disorders-and-circulating-levels-of-inflammatory-markers-results-from-a-large-longitudinal-population-based-study
#18
Jennifer Glaus, Roland von Känel, Aurélie M Lasserre, Marie-Pierre F Strippoli, Caroline L Vandeleur, Enrique Castelao, Mehdi Gholam-Rezaee, Ciro Marangoni, En-Young N Wagner, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Martin Preisig, Kathleen R Merikangas
BACKGROUND: Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α, and high sensitivity C-reactive protein (hsCRP) with anxiety disorders and its subgroups...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29232491/anhedonia-is-associated-with-suicidal-ideation-independently-of-depression-a-meta-analysis
#19
Déborah Ducasse, Gwenolé Loas, Déborah Dassa, Carla Gramaglia, Patrizia Zeppegno, Sébastien Guillaume, Emilie Olié, Philippe Courtet
BACKGROUND: Anhedonia is considered a suicide risk factor in patients with major affective disorders. Here, we wanted to quantify the association between anhedonia and current suicidal ideation according to the absence/presence of between-group differences for depressive scores and psychiatric disorders. METHODS: We performed a meta-analysis of data on studies retrieved from Medline, Web of Science, and PsycINFO from 1965 to 2016 using, among others, the terms (suicid* or depression) and anhedonia...
December 12, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29228458/seeing-the-signs-using-the-course-of-residual-depressive-symptomatology-to-predict-patterns-of-relapse-and-recurrence-of-major-depressive-disorder
#20
Floor E A Verhoeven, Klaas J Wardenaar, Henricus G Eric Ruhé, Henk Jan Conradi, Peter de Jonge
BACKGROUND: Major depressive disorder (MDD) is characterized by high relapse/recurrence rates. Predicting individual patients' relapse/recurrence risk has proven hard, possibly due to course heterogeneity among patients. This study aimed to (1) identify homogeneous data-driven subgroups with different patterns of relapse/recurrence and (2) identify associated predictors. METHODS: For a year, we collected weekly depressive symptom ratings in 213 primary care MDD patients...
December 11, 2017: Depression and Anxiety
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