journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Toxicology

journal
https://www.readbyqxmd.com/read/29761732/safety-assessment-of-polyether-lanolins-as-used-in-cosmetics
#1
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 39 polyether lanolin ingredients as used in cosmetics. These ingredients function mostly as hair conditioning agents, skin conditioning agent-emollients, and surfactant-emulsifying agents. The Panel reviewed available animal and clinical data, from previous CIR safety assessments of related ingredients and components. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761731/safety-assessment-of-alkyl-betaines-as-used-in-cosmetics
#2
Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 11 alkyl betaines as used in cosmetics. These ingredients are reported to function as hair and skin conditioning agents, antistatic agents, surfactants-cleansing agents, and viscosity-increasing agents in cosmetic products. Although there are data gaps, the shared chemical core structure, similar functions and concentrations of use in cosmetics, and the expected similarities in physicochemical properties enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each individual compound in the entire group...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761730/safety-assessment-of-tromethamine-aminomethyl-propanediol-and-aminoethyl-propanediol-as-used-in-cosmetics
#3
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Lillian J Gill, Bart Heldreth
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of tromethamine, aminomethyl propanediol, and aminoethyl propanediolas used in cosmetics. All 3 ingredients are reported to function in cosmetics as pH adjusters, and tromethamine and aminomethyl propanediol are also reported to function as fragrance ingredients. The Panel reviewed relevant animal and human data related to these ingredients, along with a previous safety assessment of aminomethyl propanediol. The Panel concluded that tromethamine, aminomethyl propanediol, and aminoethyl propanediol are safe in cosmetics in the practices of use and concentration as given in this safety assessment...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761729/safety-assessment-of-magnesium-sulfate-as-used-in-cosmetics
#4
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of magnesium sulfate, which functions as a bulking agent in cosmetic products and is reportedly used at concentrations up to 11% and 25% in leave-on and rinse-off products, respectively. The Panel noted that the history of safe medical use of magnesium sulfate provides further confidence that there are no significant toxicity concerns relating to systemic exposure to this ingredient after cosmetic product application. Furthermore, the extensive clinical experience of the Panel, including the results of numerous patch tests, indicates that magnesium salts do not have the potential to induce sensitization...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29761728/safety-assessment-of-hydrolyzed-wheat-protein-and-hydrolyzed-wheat-gluten-as-used-in-cosmetics
#5
Christina Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29642729/safety-evaluation-of-soy-leghemoglobin-protein-preparation-derived-from-pichia-pastoris-intended-for-use-as-a-flavor-catalyst-in-plant-based-meat
#6
Rachel Z Fraser, Mithila Shitut, Puja Agrawal, Odete Mendes, Sue Klapholz
The leghemoglobin protein (LegH) from soy ( Glycine max) expressed in Pichia pastoris (LegH preparation, LegH Prep) imparts a meat-like flavor profile onto plant-based food products. The safety of LegH Prep was evaluated through a series of in vitro and in vivo tests. The genotoxic potential of LegH Prep was assessed using the bacterial reverse mutation assay (Ames test) and the in vitro chromosome aberration test. LegH Prep was nonmutagenic and nonclastogenic in each test, respectively. Systemic toxicity was assessed in a 28-day dietary study in male and female Sprague Dawley rats...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29575954/ototoxicity-the-radical-drum-beat-and-rhythm-of-cochlear-hair-cell-life-and-death
#7
David V Gauvin, Joshua Yoder, Zachary J Zimmermann, Rachel Tapp
The function and structure of the auditory information processing system establishes a unique sensory environment for the "perfect storm." The battle between life and death pits the cascade of an apoptotic storm, programmed cell death cascades, against simple cell death (necrosis) pathways. Live or die, the free radical biology of oxygen and hydroxylation, and the destruction of transition metal migration through the mechanical gate sensory processes of the hair cell lead to direct access to the cytoplasm, cytoplasmic reticulum, and mitochondria of the inner workings of the hair cells...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29554825/genotoxic-effects-due-to-exposure-to-chromium-and-nickel-among-electroplating-workers
#8
Amal Mohamed Kamal El Safty, Aisha Mohamed Samir, Mona Kamal Mekkawy, Marwa Mohamed Fouad
Using chromium and nickel for electroplating is important in many industries. This process induces variable adverse health effects among exposed workers. The aim of this study is to detect the genotoxic effects of combined exposure to chromium and nickel among electroplating workers. This study was conducted on 41 male workers occupationally exposed to chromium and nickel in the electroplating section of a factory compared to 41 male nonexposed individuals, where full history and clinical examination were performed...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29554823/age-related-memory-impairment-associated-with-decreased-endogenous-estradiol-in-the-hippocampus-of-female-rats
#9
Siriporn Chamniansawat, Chattraporn Sawatdiyaphanon
It is widely known that not only the gonadal estradiol (E2) but also hippocampal E2 plays an essential role in memory process. However, the role of hippocampal E2-enhanced memory mechanism during aging is largely unknown. The aim of the present study was to investigate the effect of age on E2 concentration, the expression level of its receptors, and key steroidogenic enzymes in hippocampus. We also investigated the effect of microglia activation on E2 synthesis in hippocampal neurons. The results showed that serum E2 was higher in 19-month-old (aged) rats, which exhibited spatial memory decline in the Morris water maze (MWM) test when compared to the younger rats...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29554821/renal-and-hematologic-comparative-effects-of-dissociated-agonist-of-the-glucocorticoid-receptor-and-prednisone-in-dogs-with-and-without-food-restriction
#10
Zaher A Radi, W Mark Vogel, Timothy LaBranche, Joseph A Dybowski, Marjorie A Peraza, Susan S Portugal, Daniel J Lettiere
Glomerulopathy and body weight gain were noted after chronic oral administration of a novel nonsteroidal dissociated agonist of the glucocorticoid receptor compound, fosdagrocorat, to beagle dogs fed an ad libitum diet. To further investigate the role of diet and treatment with either fosdagrocorat or the glucocorticoid comparator, prednisone, on renal safety, a 13-week investigative study was conducted in beagle dogs. Renal histopathology, clinical chemistry, urinalysis, glomerular filtration rate (GFR), body weight, heart rate, blood pressure (BP), and hematology were investigated in restricted- and ad libitum-fed dogs administered prednisone (2...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29587557/bile-acids-as-potential-biomarkers-to-assess-liver-impairment-in-polycystic-kidney-disease
#11
William J Brock, James J Beaudoin, Jason R Slizgi, Mingming Su, Wei Jia, Sharin E Roth, Kim L R Brouwer
Polycystic kidney disease is characterized by the progressive development of kidney cysts and declining renal function with frequent development of cysts in other organs including the liver. The polycystic kidney (PCK) rat is a rodent model of polycystic liver disease that has been used to study hepatorenal disease progression and evaluate pharmacotherapeutic interventions. Biomarkers that describe the cyst progression, liver impairment, and/or hepatic cyst burden could provide clinical utility for this disease...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29587556/editor-s-note
#12
Mary Beth Genter
No abstract text is available yet for this article.
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29554824/trichloroethylene-alters-th1-th2-th17-treg-paradigm-in-mice-a-novel-mechanism-for-chemically-induced-autoimmunity
#13
Shu-Long Li, Yun Yu, Peng Yang, Hui Wang, Cheng Zhang, Min Liu, Jia-Xiang Zhang, Tong Shen, Changhao Wu, Qi-Xing Zhu
The role of environmental factors in autoimmune diseases has been increasingly recognized. While major advance has been made in understanding biological pathogen-induced autoimmune diseases, chemically triggered autoimmunity is poorly understood. Trichloroethylene (TCE), a common environmental pollutant, has recently been shown to induce autoimmunity. This study explored whether TCE could cause imbalance of T helper (Th) cell subsets which would contribute to the pathogenesis of TCE-induced medicamentosa-like dermatitis...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29554822/evidence-for-the-involvement-of-the-dopaminergic-system-in-seizure-and-oxidative-damage-induced-by-tramadol
#14
Behnaz Bameri, Fatemeh Shaki, Nematollah Ahangar, Ramin Ataee, Mahedeh Samadi, Hamidreza Mohammadi
Tramadol (TR) is a synthetic analgesic drug with central function that can induce seizures even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not clear, but inhibition of the serotonin and nitric oxide pathways and inhibitory effects on GABA receptors are the most common hypotheses about the seizure-inducing mechanism of the TR. This study aimed to evaluate the role of dopaminergic system on the seizure and oxidative damage induced by TR using agonist and antagonist drugs of this system in the Albino mice...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29357766/a-toxicological-assessment-of-creatyl-l-leucine
#15
Robin A Reddeman, Róbert Glávits, John R Endres, Timothy S Murbach, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné
A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leucine, a synthetic compound, in rats in accordance with internationally accepted guidelines. There was no evidence of mutagenicity in a bacterial reverse mutation test and in an in vitro mammalian chromosomal aberration test. There was no genotoxic activity observed in an in vivo mammalian micronucleus test at concentrations up to the limit dose of 2,000 mg/kg bw/d. Creatyl-l-leucine did not cause mortality or toxic effects in Hsd...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29357765/accessible-mirnas-as-novel-toxicity-biomarkers
#16
Wendy J Bailey, Warren E Glaab
Novel tissue injury biomarkers have recently been identified that outperform or add value to the conventional safety biomarkers. These novel biomarkers have enhanced sensitivity and/or specificity in monitoring drug-induced tissue injury in a variety of tissues, included liver, kidney, and skeletal muscle. Among these novel biomarkers, microRNAs (miRNAs) are one type in particular that have received much attention in recent years. These microRNAs are short, endogenous noncoding nucleic acids that are involved in modulation and regulation of mRNA transcripts...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29357719/role-of-risk-of-bias-in-systematic-review-for-chemical-risk-assessment-a-case-study-in-understanding-the-relationship-between-congenital-heart-defects-and-exposures-to-trichloroethylene
#17
Daniele Wikoff, Jon D Urban, Seneca Harvey, Laurie C Haws
The National Academy of Science has recommended that a risk of bias (RoB; credibility of the link between exposure and outcome) assessment be conducted on studies that are used as primary data sources for hazard identification and dose-response assessment. Few applications of such have been conducted. Using trichloroethylene and congenital heart defects (CHDs) as a case study, we explore the role of RoB in chemical risk assessment using the National Toxicology Program's Office of Health Assessment and Translation RoB tool...
March 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29923437/effect-of-cyclophosphamide-treatment-on-central-and-effector-memory-t-cells-in-mice
#18
Marcin Włodarczyk, Elżbieta Ograczyk, Magdalena Kowalewicz-Kulbat, Magdalena Druszczyńska, Wiesława Rudnicka, Marek Fol
Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. The important question is whether cyclophosphamide (CP), as immunosuppressive agent used in cancer therapy and in some autoimmune diseases, may act on the memory T-cell population. We investigated the effect of CP on the percentage of central memory T cells (TCM ) and effector memory T cells (TEM ) in the mouse model of CP-induced immunosuppression (8-10-week-old male C57BL/6 mice CP treated for 7 days at the daily dose of 50 μg/g body weight [bw], manifested the best immunosuppression status, as compared to lower doses of CP: 10 or 20 μg/g bw)...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29923436/quantitative-evaluation-of-cytochrome-p450-3a4-inhibition-and-hepatotoxicity-in-heparg-3-d-spheroids
#19
Dae-Seop Shin, Hyewon Seo, Jung Yoon Yang, Jeongmin Joo, So Hee Im, Seong Soon Kim, Sang Kyum Kim, Myung Ae Bae
Predicting drug-drug interactions (DDIs) is an important step during drug development to avoid unexpected side effects. Cytochrome P450 (CYP) 3A4 is the most abundant human hepatic phase I enzyme, which metabolizes >50% of therapeutic drugs. Therefore, it is essential to test the potential of a drug candidate to induce CYP3A4 expression or inhibit its activity. Recently, 3-dimensional (3-D) mammalian cell culture models have been adopted in drug discovery research to assess toxicity, DDIs, and pharmacokinetics...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29916280/similar-and-differential-canonical-pathways-and-biological-processes-associated-with-multiwalled-carbon-nanotube-and-asbestos-induced-pulmonary-fibrosis-a-1-year-postexposure-study
#20
Julian M Dymacek, Brandi N Snyder-Talkington, Rebecca Raese, Chunlin Dong, Salvi Singh, Dale W Porter, Barbara Ducatman, Michael G Wolfarth, Michal E Andrew, Lori Battelli, Vincent Castranova, Yong Qian, Nancy L Guo
Respiratory exposure to multiwalled carbon nanotubes (MWCNT) or asbestos results in fibrosis; however, the mechanisms to reach this end point may be different. A previous study by our group identified pulmonary effects and significantly altered messenger RNA (mRNA) signaling pathways following exposure to 1, 10, 40, and 80 µg MWCNT and 120 µg crocidolite asbestos on mouse lungs over time at 1-month, 6-month, and 1-year postexposure following pulmonary aspiration. As a continuation to the above study, this current study took an in-depth look at the signaling pathways involved in fibrosis development at a single time point, 1 year, and exposure, 40 µg MWCNT, the lowest exposure at which fibrosis was pathologically evident...
January 1, 2018: International Journal of Toxicology
journal
journal
32758
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"