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International Journal of Toxicology

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https://www.readbyqxmd.com/read/29357766/a-toxicological-assessment-of-creatyl-l-leucine
#1
Robin A Reddeman, Róbert Glávits, John R Endres, Timothy S Murbach, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné
A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leucine, a synthetic compound, in rats in accordance with internationally accepted guidelines. There was no evidence of mutagenicity in a bacterial reverse mutation test and in an in vitro mammalian chromosomal aberration test. There was no genotoxic activity observed in an in vivo mammalian micronucleus test at concentrations up to the limit dose of 2,000 mg/kg bw/d. Creatyl-l-leucine did not cause mortality or toxic effects in Hsd...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29357765/accessible-mirnas-as-novel-toxicity-biomarkers
#2
Wendy J Bailey, Warren E Glaab
Novel tissue injury biomarkers have recently been identified that outperform or add value to the conventional safety biomarkers. These novel biomarkers have enhanced sensitivity and/or specificity in monitoring drug-induced tissue injury in a variety of tissues, included liver, kidney, and skeletal muscle. Among these novel biomarkers, microRNAs (miRNAs) are one type in particular that have received much attention in recent years. These microRNAs are short, endogenous noncoding nucleic acids that are involved in modulation and regulation of mRNA transcripts...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29357719/role-of-risk-of-bias-in-systematic-review-for-chemical-risk-assessment-a-case-study-in-understanding-the-relationship-between-congenital-heart-defects-and-exposures-to-trichloroethylene
#3
Daniele Wikoff, Jon D Urban, Seneca Harvey, Laurie C Haws
The National Academy of Science has recommended that a risk of bias (RoB; credibility of the link between exposure and outcome) assessment be conducted on studies that are used as primary data sources for hazard identification and dose-response assessment. Few applications of such have been conducted. Using trichloroethylene and congenital heart defects (CHDs) as a case study, we explore the role of RoB in chemical risk assessment using the National Toxicology Program's Office of Health Assessment and Translation RoB tool...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29356587/biochemical-oxidative-and-physiological-changes-caused-by-acute-exposure-of-fentanyl-and-its-3-analogs-in-rodents
#4
Shiv Kumar Yadav, Deo Kumar, Pravin Kumar, Pradeep Kumar Gupta, Rahul Bhattacharya
Synthesis and bioefficacy of fentanyl and its 8 new 1-substituted analogs (1-8) were earlier reported by us. Of these 8 compounds, N-(1-(2-phenoxyethyl)-4-piperidinyl)propionanilide (2), N-isopropyl-3-(4-( N-phenylpropionamido)piperidin-1-yl)propanamide (5), and N- t-butyl-3-(4-( N-phenylpropionamido)piperidin-1-yl) propanamide (6) were found to be more effective and less toxic compared to fentanyl. The present study reports the acute effect of fentanyl (0.50 Median Lethal Dose (LD50); intraperitoneal) and its 3 analogs (2, 5, and 6) on various biochemical and oxidative parameters in mice and various physiological parameters in rats...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29303016/a-toxicological-evaluation-of-chlamydomonas-reinhardtii-a-green-algae
#5
Timothy S Murbach, Róbert Glávits, John R Endres, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné
There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source is the green algae Chlamydomonas reinhardtii, the only green algae that has been studied as a model organism for many biological processes ranging from photosynthesis to flagellar movement. However, its potential as a safe nutritional source for use in various foods has not been thoroughly investigated. To assess the safety of C reinhardtii for use as a nutritional human food ingredient, in accordance with internationally accepted standards, the genotoxic potential and repeated-dose oral toxicity of the dried C reinhardtii (THN 6) algal biomass was investigated...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29382289/editor-s-note
#6
Mary Beth Genter
No abstract text is available yet for this article.
January 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29382288/american-college-of-toxicology-2017-annual-meeting-poster-abstracts
#7
(no author information available yet)
No abstract text is available yet for this article.
January 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243542/safety-assessment-of-dimethiconol-and-its-esters-and-reaction-products-as-used-in-cosmetics
#8
Wilbur Johnson, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243541/safety-assessment-of-benzyl-alcohol-benzoic-acid-and-its-salts-and-benzyl-benzoate
#9
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Benzyl alcohol, benzoic acid and its salts, and benzyl benzoate function mostly as fragrance ingredients/preservatives in cosmetic products. The Cosmetic Ingredient Review Expert Panel previously established concentration limits for benzyl alcohol, benzoic acid, and sodium benzoate in cosmetics and determined that the available data were insufficient to support the safety of these ingredients during inhalation exposure. After reviewing newly available data, it was concluded that benzyl alcohol, benzoic acid and its salts, and benzyl benzoate are safe in the present practices of use and concentration described in this safety assessment...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243540/safety-assessment-of-plant-derived-fatty-acid-oils
#10
Christina L Burnett, Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 244 plant-derived fatty acid oils as used in cosmetics. Oils are used in a wide variety of cosmetic products for their skin conditioning, occlusive, emollient, and moisturizing properties. Since many of these oils are edible, and their systemic toxicity potential is low, the review focused on potential dermal effects. The Panel concluded that the 244 plant-derived fatty acid oils are safe as used in cosmetics.
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29241425/book-review-neurotoxicity-of-nanomaterials-and-nanomedicine-jiang-xinguo-gao-huile-neurotoxicity-of-nanomaterials-and-nanomedicine-academic-press-2017-358-pp-isbn-978-0-12-804598-5-105-00-eisbn-978-0-12-804620-5-105-00-bundled-hardcopy%C3%A2-and-ebook-180-00
#11
https://www.readbyqxmd.com/read/29241424/book-review-nanoparticles-and-the-immune-system-safety-and-effects-boraschi-diana-duschl-albert-eds-nanoparticles-and-the-immune-system-safety-and-effects-academic-press-cambridge-massachusetts-usa-2014-138-pp-49-95-paperback-isbn-9780124080850-49-95-ebook
#12
https://www.readbyqxmd.com/read/29202623/nonclinical-development-of-anx005-a-humanized-anti-c1q-antibody-for-treatment-of-autoimmune-and-neurodegenerative-diseases
#13
Janice A Lansita, Kirsten M Mease, Haiyan Qiu, Ted Yednock, Sethu Sankaranarayanan, Susan Kramer
ANX005 is a humanized immunoglobulin G4 recombinant antibody against C1q that inhibits its function as the initiating molecule of the classical complement cascade. The safety and tolerability of ANX005 are currently being evaluated in a phase I trial in healthy volunteers ( www.clinicaltrials.gov Identifier: NCT03010046). Inhibition of C1q can be applied therapeutically in a broad spectrum of diseases, including acute antibody-mediated autoimmune disease, such as Guillain-Barré syndrome (GBS), and in chronic diseases of the central nervous system involving complement-mediated neurodegeneration, such as Alzheimer's disease (AD)...
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025349/isostearamidopropyl-morpholine-lactate
#14
Monice M Fiume
No abstract text is available yet for this article.
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025348/safety-assessment-of-diethanolamine-and-its-salts-as-used-in-cosmetics
#15
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports. Since data were not available for each individual ingredient, and since the salts dissociate freely in water, the Panel extrapolated from previous reports to support safety...
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025347/4-chlororesorcinol
#16
Christina L Burnett
No abstract text is available yet for this article.
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025346/alpha-hydroxy-acids
#17
Monice M Fiume
No abstract text is available yet for this article.
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025345/the-cosmetic-ingredient-review-program-expert-safety-assessments-of-cosmetic-ingredients-in-an-open-forum
#18
Ivan J Boyer, Wilma F Bergfeld, Bart Heldreth, Monice M Fiume, Lillian J Gill
The Cosmetic Ingredient Review (CIR) is a nonprofit program to assess the safety of ingredients in personal care products in an open, unbiased, and expert manner. Cosmetic Ingredient Review was established in 1976 by the Personal Care Products Council (PCPC), with the support of the US Food and Drug Administration (USFDA) and the Consumer Federation of America (CFA). Cosmetic Ingredient Review remains the only scientific program in the world committed to the systematic, independent review of cosmetic ingredient safety in a public forum...
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025344/glutaral
#19
Christina L Burnett
No abstract text is available yet for this article.
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025343/retinol-and-retinyl-palmitate
#20
Wilbur Johnson
No abstract text is available yet for this article.
September 2017: International Journal of Toxicology
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