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Hematology (Amsterdam, Netherlands)

Pingli Yao, Xia He, Rong Zhang, Rongsheng Tong, Hongtao Xiao
OBJECTIVES: The effect of methotrexate (MTX)-related adverse reaction on hematologic neoplasms patients is controversial. We performed this meta-analysis to assess the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism and the adverse reaction after MTX using. METHODS: We searched for qualified studies according to PubMed, the Cochrane Library, and the Web of Science. The meta-analysis was performed by Review Manager 5.3. The analysis was conducted to compare risk ratios (RRs) with the corresponding 95% confidence interval (95% CI) to evaluate the relationship between different toxicity reactions and the genotype of MTHFR...
July 19, 2018: Hematology (Amsterdam, Netherlands)
José Carlos Jaime-Pérez, Goel Treviño-Reyna, Patrizia Aguilar-Calderón, Olga G Cantú-Rodríguez, Luis Javier Marfil-Rivera, David Gómez-Almaguer
OBJECTIVES: To demonstrate the importance of regional efforts to register features and report frequency of hematology diseases in the context of incomplete national registries. METHODS: Frequencies and salient characteristics of hematologic diseases in Northeast Mexico were documented in a reference center at a tertiary care university hospital during the decade 2005-2015. Disease categories were grouped by age, sex and diagnosis. Age group distribution followed WHO guidelines in years as children (0-17), adults (18-64) and elders (+65)...
July 16, 2018: Hematology (Amsterdam, Netherlands)
Sebaranjan Biswal, Huma Rizwan, Sweta Pal, Silpa Sabnam, Preetinanda Parida, Arttatrana Pal
BACKGROUND: The phenotypic expression of sickle cell disease (SCD) is a complex pathophysiologic condition. However, sickle erythrocytes might be the cause for multiple sources of pro-oxidant processes with consequent linked to chronic and systemic oxidative stress. Herein, we explored the SCD phenomena could be the result in formation of oxidative stress as well as inflammation in children. MATERIAL AND METHODS: Blood samples of 147 SCD subjects were evaluated...
July 16, 2018: Hematology (Amsterdam, Netherlands)
Junyue Fang, Li Lin, Ying Wang, Dijin Lin, Chunyue Liu, Qiaozi Sunlong, Xianghua Lin
OBJECTIVES: To investigate the immune status of children with very severe aplastic anemia (VSAA), and evaluate the frequencies of CD20+ B cells and Regulatory T cells (Tregs) as potential markers for evaluating the therapeutic efficacy and prognosis. METHODS: We systematically analyzed CD20+ B cells and Tregs using Flow Cytometry in 36 children with VSAA (14 newly diagnosed cases and 22 cases in remission after therapy with HDIVIG + r-ATG + CSA). RESULTS: In newly diagnosed VSAA patients, the percentage of CD20+ B cells was higher than that in healthy children (P < ...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Guray Saydam, Ibrahim Celalettin Haznedaroglu, Leylagul Kaynar, Akif S Yavuz, Ridvan Ali, Birol Guvenc, Olga M Akay, Zafer Baslar, Ugur Ozbek, Mehmet Sonmez, Demet Aydin, Mustafa Pehlivan, Bulent Undar, Simten Dagdas, Orhan Ayyildiz, Gülnur Akin, Ilkiz M Dag, Osman Ilhan
OBJECTIVES: This report presents final results (24 months of follow-up) from the first prospective, national study of frontline nilotinib in chronic myeloid leukemia (CML) patients in Turkey. METHODS: Patients with newly diagnosed Philadelphia chromosome-positive CML in chronic phase (CML-CP; N = 112) received nilotinib 300 mg twice daily. The primary endpoint, which was the cumulative rate of major molecular response (MMR; BCR-ABL1 ≤ 0.1% on the International Scale [BCR-ABL1IS ]) by 12 months, was previously reported (66...
July 11, 2018: Hematology (Amsterdam, Netherlands)
L De Roeck, L Michaux, K Debackere, E Lierman, P Vandenberghe, T Devos
OBJECTIVES: CML, PV, ET and PMF are so called classical MPN with distinct clinical phenotypes. The discovery of the BCR-ABL1 translocation and mutations in driver genes JAK2, MPL and CALR has provided novel insights in their pathogenesis. While these mutations are thought to be mutually exclusive, rare cases of MPN with coexisting driver mutations have been reported. However, little is known about the clinical, biological and molecular characteristics of these patients and the interaction of the neoplastic clones...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Rungtip Putburee, Arunee Jetsrisuparb, Supan Fucharoen, Amporn Tripatara
BACKGROUND: Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress. Mitochondrial ferritin, encoded by the FTMT gene is an iron-storage protein in the mitochondria. The aim of this work was to investigate the expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia who were regularly transfused and rarely transfused compared with healthy controls and to evaluate the relationships of the levels of FTMT mRNA with malondialdehyde (MDA) and ferritin in these patients...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Niloofar Naderi, Fariba Ebrahimzadeh, Mohammad Jazebi, Ali Namvar, Mehrdad Hashemi, Azam Bolhassani
OBJECTIVES: Development of neutralizing antibodies against factor VIII is the major complication in hemophilia care which makes replacement therapies ineffective. The reports showed that inflammatory cytokines play an important role in inhibitor production. In the present study, the relationship between inhibitor development and the polymorphisms of two cytokine genes was studied in severe hemophiliac patients from Iran. METHODS: In this case-control study, three polymorphisms of immune regulatory genes [TGF-β (rs1982037) and IL-2 (rs2069762, rs4833248)] were analyzed in 100 Iranian hemophilia A patients divided into 55 inhibitor positive and 45 inhibitor negative patients using Tetra primer ARMS PCR, and DNA sequencing...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Ivan Krecak, Velka Gveric-Krecak, Pavle Roncevic, Sandra Basic-Kinda, Josipa Gulin, Ivana Lapic, Ksenija Fumic, Ivana Ilic, Ivana Horvat, Renata Zadro, Hrvoje Holik, Bozena Coha, Nena Peran, Igor Aurer, Nadira Durakovic
OBJECTIVES: Serum chitotriosidase activity (CHIT1) is a biomarker of macrophage activation with an important role in inflammation-induced tissue remodeling and fibrosis. Macrophages have been described to play a crucial role in regulating pathological erythropoiesis in polycythemia vera (PV). The aim of this study was to evaluate CHIT1 in patients diagnosed with Philadelphia-negative myeloproliferative neoplasms (MPNs). METHODS: Using fluorometric assay, we measured CHIT1 in 28 PV, 27 essential thrombocythemia (ET), 17 primary myelofibrosis (PMF), 19 patients with secondary myelofibrosis and in 25 healthy controls...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Rui Deng, Fang-Yi Fan, Hai Yi, Fang Liu, Guang-Cui He, Hao-Ping Sun, Yi Su
OBJECTIVES: Acute myeloid leukaemia (AML) is a malignant haematological disease that remains difficult to cure. Cytotoxic T cell (CTL) adoptive infusion therapy may be conducive to tumour remission by boosting physical immunity. Furthermore, programmed death receptor-1 (PD-1) blockade immunotherapy has shown tremendous success in many cancer therapies. METHOD: We attempted to combine these two immunotherapy strategies to intervene in AML by generating AML cellspecific cytotoxic T lymphocytes in vitro and in vivo with an AML cell strain expressing specific antigens...
June 30, 2018: Hematology (Amsterdam, Netherlands)
Wenyuan Lai, Yini Wang, Jingshi Wang, Lin Wu, Zhili Jin, Zhao Wang
OBJECTIVES: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis is the most common type of infection-associated HLH. Previous studies were focused on pediatric EBV-HLH patients, therefore there lack of adult data. METHOD: We performed a retrospective analysis of 133 EBV-HLH patients (≥14 years old) in Beijing Friendship Hospital from March 2009 to April 2016 to evaluate the clinical manifestation and the effects and prognosis of existing regimens of EBV-HLH in adult and adolescents...
June 29, 2018: Hematology (Amsterdam, Netherlands)
Yongsheng Xiang, Xiaofen Zhou
OBJECTIVE: To investigate the correlation of octamer-binding transcription factor 4 (OCT4) expression with clinicopathological features and its predictive value for treatment response as well as survival profiles in de novo acute myeloid leukaemia (AML) patients. METHOD: One hundred fifty-two de novo AML patients and 52 non-hematologic malignancy patients were recruited in this prospective cohort study. OCT4 expression was determined in bone marrow sample collected before treatment...
June 27, 2018: Hematology (Amsterdam, Netherlands)
Arzu Zeynep Karabay, Asli Koc, Tulin Ozkan, Yalda Hekmatshoar, Buket Altinok Gunes, Asuman Sunguroglu, Zeliha Buyukbingol, Arzu Atalay, Fugen Aktan
OBJECTIVE: Chronic myelomonocytic leukemia (CML) is a myeloproliferative disorder characterized with the constitutive activation of Bcr-Abl tyrosine kinase which is a target for imatinib, the first line treatment option for CML. Constitutive activation of NFκB and β-catenin signaling promotes cellular proliferation and survival and resistance to Imatinib therapy in CML. Akirin-2 is a nuclear protein which is required for NFκB dependent gene expression as a cofactor and has been linked to Wnt/beta-catenin pathway...
June 26, 2018: Hematology (Amsterdam, Netherlands)
Jiasheng Xu, Weimin Zhou
OBJECTIVE: To investigate the relationship between gene polymorphism of MTRR A66G and lower extremity deep venous thrombosis (DVT). METHODS: Two hundred and two patients with DVT as experimental group and 240 normal adults (control group) were enrolled in this study and white blood cells were collected, respectively. Polymorphism of the 66 loci in MTRR gene was detected by polymerase chain reaction-sequence-specific primers (PCR-SSP) in two groups. The frequency of genotype and allele distribution of each group was compared...
June 21, 2018: Hematology (Amsterdam, Netherlands)
Hajime Senjo, Takakazu Higuchi, Sadamu Okada, Osamu Takahashi
OBJECTIVE: To elucidate conditions which cause elevation of the serum ferritin, extent of the elevation in each condition, and clinical relevance of hyperferritinemia in general practice. METHODS: We retrospectively studied medical records of all patients who had at least one serum ferritin measurement above 500 μg L-1 . Patients who had a marked elevation of the serum ferritin over 10,000 μg L-1 were studied separately. RESULTS: We studied 1394 patients to identify the etiologies of hyperferritinemia...
June 19, 2018: Hematology (Amsterdam, Netherlands)
Andi Wang, Hua Zhong
OBJECTIVES: To summarize the effects of the bone marrow niche on hematopoiesis and leukemogenesis and discuss the chemotherapy resistance that can arise from interactions between the niche and leukemia stem cells. METHODS: We review the major roles of the bone marrow niche in cell proliferation, adhesion and drug resistance. The signaling pathways and major molecular participants in the niche are discussed. We also address potential niche-targeting strategies for the treatment of acute myeloid leukemia (AML)...
June 14, 2018: Hematology (Amsterdam, Netherlands)
Fang Zhou, Baoan Chen
OBJECTIVES: E26 transformation-specific variant 6 gene (ETV6) is one of the most consistently rearranged genes in acute leukaemia. It encodes a principal hematopoietic transcription factor. METHODS: We performed a systematic review focusing on the mechanisms responsible for etv6 acquisition, and its effect on the development of AML. We also review the Characteristics of ETV6 mutations and its fusion genes. Finally, for using ETV6 as a molecular target, we discuss future therapeutic approaches available to mitigate the associated disease...
June 12, 2018: Hematology (Amsterdam, Netherlands)
Xiongxin Zhang, Shifang Yu, Gang Deng, Yunlei He, Qiang Li, Lu Yu, Yong Yu
OBJECTIVES: The aim of this study is to investigate the effects of a Nitric oxide (NO) donor, S-nitrosoglutathione (GSNO), on apoptosis and the improvement of preservation quality in apheresis platelets. METHODS: A GSNO solution - to make the final GSNO concentration of 100 uM was added into fresh apheresis platelets, and the parameters associated with platelet morphology, metabolism, and apoptosis were dynamically monitored for seven days. RESULTS: The results showed that the NO level was remarkably higher during the whole storage stageafter GSNO injection...
June 11, 2018: Hematology (Amsterdam, Netherlands)
Amit Sharma, Kanwaljeet Singh, Arijit Biswas, Ravi Ranjan, Kamal Kishor, Hareram Pandey, Ravi Kumar, Manoranjan Mahapatra, Johannes Oldenburg, Renu Saxena
OBJECTIVES: To evaluate the association of interleukin 6 (IL-6) levels with deep vein thrombosis (DVT) and to assess the impact of IL-6 promoter polymorphisms (-174G > C, -572G > C and -597G > A) on its plasma levels and their influence in the development of DVT in India. METHODS: One hundred DVT patients and 100 age and sex-matched healthy controls were study subjects. IL-6 polymorphisms were identified by polymerase chain reaction-restriction fragment length polymorphism...
June 11, 2018: Hematology (Amsterdam, Netherlands)
Rouslan Kotchetkov, Erin Ellison, Jesse McLean, Bryn Pressnail, Derek Nay
BACKGROUND: Patients with a single hematological malignancy may be unexpectedly diagnosed with a clonally unrelated synchronous dual hematological malignancy (SDHM). The presence of a secondary hematological malignancy may be overlooked and only identified in situations presenting with discordant clinical or laboratory findings. Clinical management of these patients can be challenging, in part due to the relatively unknown etiopathology of SDHM and the impact of therapy on the secondary malignancy...
June 7, 2018: Hematology (Amsterdam, Netherlands)
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