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Hematology (Amsterdam, Netherlands)

Amira Mohamed Foad Shehata, Amira I Aldesoky, Suzy F Gohar
OBJECTIVES: Although many studies have assessed numerous molecular and immunohistochemical prognostic markers for diffuse large Bcell lymphoma (DLBCL), there is always a need for simple widely available markers. This study was planned to illustrate the clinical significance of baseline plasma fibrinogen levels in DLBCL patients. METHODS: We prospectively investigated 76 DLBCL patients treated with rituximab plus cyclophosphamide, vincristine, doxorubicin and hostacortine between August 2015 and February 2018...
September 10, 2018: Hematology (Amsterdam, Netherlands)
Preeti Tripathi, Priyanka Mishra, Ravi Ranjan, Seema Tyagi, Tulika Seth, Renu Saxena
OBJECTIVE: Factor VII deficiency is the commonest of the rare bleeding disorders with limited knowledge on clinical profile. The objective of this study was to study the prevalence and clinico-hematological profile of factor VII-deficient patients. METHODS: It is a retrospective observational study of probable inherited factor VII deficiency covering 18 months. Their clinical profile, family history, investigation and treatment records were studied in detail. RESULTS: The study group comprised of total 12 factor VII deficiency cases with mean age of 17...
September 7, 2018: Hematology (Amsterdam, Netherlands)
Signe Sperling, Pernille J Vinholt, Ulrik Sprogøe, Mark H Yazer, Henrik Frederiksen, Christian Nielsen
OBJECTIVES: Reduced platelet (PLT) function during storage has been shown for buffy-coat-derived platelet concentrates (BCP) and apheresis platelet units (AP), while for whole blood (WB) it has not been well studied. The aim of this study was to investigate PLT function in these blood products throughout storage using a novel flow cytometric assay. METHODS: Flow cytometric measurement of agonist-induced platelet aggregation, CD62P expression and PAC-1 binding during storage in BCP, AP (1-9 days at 20°C) and WB (1-21 days at 2-6°C)...
August 31, 2018: Hematology (Amsterdam, Netherlands)
Felix Gaytan-Morales, Francisco Alejo-Gonzalez, Alfonso Reyes-Lopez, Miguel Palomo, Laura Rodriguez-Romo, Laura Villareal-Martínez, Adriana Sandoval-González, Aracely Lopez-Facundo, Isidoro Tejocote-Romero, Rocio Cárdenas-Cardos, Marco Aguilar-Ortiz, Farina Arreguin-Gonzalez, Eduardo Baños-Rodriguez, Deyanira Cortes-Alva, Andrea Ellis-Irigoyen, Gladys García-Becerra, Marcela Rodriguez-Campos, Pablo Gonzalez-Montalvo, Oscar Gonzalez-Ramella, Alberto Olaya-Vargas
OBJECTIVE: Mature B-cell non-Hodgkin lymphoma (B-NHL) comprises more than 50% of all non-Hodgkin lymphoma (NHL) in children and adolescents. An official report published by the Mexican National Center for the Control and Prevention of Cancer in the Pediatric and Adolescent Populations, reported a lymphoma OS of 71% (including all Hodgkin and NHL). The Mexican Association of Pediatric Oncology and Hematology conducted a retrospective study to analyze the clinical characteristics and outcomes of children with diagnosis of B-NHL in Mexico, in order to perceive the main areas of improvement in the health care...
August 27, 2018: Hematology (Amsterdam, Netherlands)
Rajib De, Atreyee Dutta, Tuphan Kanti Dolai, Kakoli Ghosh, Ajanta Halder
OBJECTIVES: Interleukin-2 (alias: IL-2, TCGF, Lymphokine), a type of interleukin, is also a potent signalling molecule in the signalling cascade of the immune-mediated activation of T Lymphocytes leading to the destruction of haematopoietic stem cell (HSC) which is the basis of acquired aplastic anaemia (AAA). The objective was to study the association of IL-2 in the bone marrow plasma (BMP) and peripheral blood plasma (PBP) in AAA patients. METHODS: A total of 52 BMP and PBP-paired samples (both from the same patients) was collected from the confirmed AAA patients and 10 healthy individuals...
August 23, 2018: Hematology (Amsterdam, Netherlands)
Yi-Cun Wu, Xiao-Mei Zhang, Yuan-Dong Zhu, Wei Wu
OBJECTIVES: In myelodysplastic syndrome (MDS), the prognostic role of monosomal karyotype (MK), defined as at least two autosomal monosomies or a single monosomy associated with at least one additional structural abnormality, remained controversial. Therefore, we conducted a meta-analysis to address this issue. METHODS: PubMed, Embase, Web of Science, Medline, and the Cochrane Library were retrieved. We extracted hazard ratios (HRs) and the corresponding 95% confidential intervals (CIs) for overall survival (OS) on patients with MK versus those without, as well as on MK patients with monosomies of chromosome 7 and/or 5 versus those without from the available studies...
August 21, 2018: Hematology (Amsterdam, Netherlands)
Christopher Kim, Kara Delaney, Michelle McNamara, Victoria Chia, Vadim Romanov
OBJECTIVES: Minimal residual disease (MRD) is a strong prognostic factor in acute lymphoblastic leukemia (ALL), which progresses quickly and is fatal within months if untreated. This study explored use of MRD testing in adult and pediatric B-cell ALL patients, and academic versus community settings. METHODS: A survey was administered to US-based hematologists/oncologists currently managing ≥5 B-cell ALL patients and using MRD tests. Descriptive analyses (frequencies and percentages) and Pearson's chi square testing assessed any differences in various characteristics...
August 21, 2018: Hematology (Amsterdam, Netherlands)
Takashi Ishida, Koji Miyazaki, Sosei Okina, Tomomi Miyata, Kei Hayama, Masaaki Higashihara, Takahiro Suzuki
Objectives and importance: Tyrosine kinase inhibitors (TKIs) are indispensable for the treatment of chronic myeloid leukemia (CML). However, alternative splicing variants have been recently proposed as mechanisms of TKI resistance, although the clinical significance of these mutations remains controversial. We here present the long-term clinical courses of three CML patients harboring such unique mutations and try to assess their clinical significances. Moreover, the exon 6 frameshift presented here has been rarely reported, which may provide important information on this rare mutation...
August 20, 2018: Hematology (Amsterdam, Netherlands)
Kensuke Kayamori, Katsuhiro Shono, Masahiro Onoda, Akira Yokota
OBJECTIVES: Chemoimmunotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with rituximab (R-CHOP) is currently the first-line therapy for diffuse large B-cell lymphoma (DLBCL). However, management of elderly patients is challenging and often requires dose reductions or prolonged treatment intervals. We investigated the proper dose of R-CHOP for them. METHODS: At our institute, for DLBCL patients aged 65-79 and ≥80 years, we had reduced CHOP dose to 5/6 and 7/12, respectively, and retrospectively evaluated the reduced-dose R-CHOP...
August 11, 2018: Hematology (Amsterdam, Netherlands)
Mable Misha Singh, Ravindra Kumar, Satyendra Tewari, Sarita Agarwal
BACKGROUND: Cardiomyocytes are particularly susceptible to complications from iron loading. The blood transfusions in thalassaemia major create loading of iron that cannot be naturally excreted. Apolipoprotein E and Glutathione S-transferase act as the scavenger of free radicals, which are generated due to excess iron. The variants of Apolipoprotein E (ApoE) and Glutathione S-transferase (GST) may play a role in oxidative damage-induced cardiomyopathy, so we aimed to study the association of genetic variants of these genes on diastolic dysfunction in our patients...
August 10, 2018: Hematology (Amsterdam, Netherlands)
Yigui Tang, Changgen Shi, Zhiyuan Wu, Ni Fan, Xiao Xu, Zhihua Kang, Xinju Zhang, Weizhe Ma, Ming Guan
BACKGROUND: Calreticulin (CALR) exon 9 frameshift mutations have recently been identified in 30-40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) without JAK2 or MPL mutations. We aimed to develop a qPCR assay to screen type I and II mutations of CALR. METHODS: Three different fluorescent-labeled hydrolysis probes and one pair of primers in a closed-tube system were developed to detect CALR type I and II mutations and distinguish them from wild-type...
August 6, 2018: Hematology (Amsterdam, Netherlands)
J Stoffman, N G Andersson, B Branchford, K Batt, R D'Oiron, C Escuriola Ettingshausen, D P Hart, V Jiménez Yuste, K Kavakli, M E Mancuso, K Nogami, C Ramírez, R Wu
OBJECTIVE: To identify ways that provision of hemophilia care can be maximized at the local level, irrespective of available resources or cultural or geographic challenges. METHODS: The SHIELD group used its multinational experience to share examples of local initiatives that have been employed to deliver optimal hemophilia care. RESULTS: The examples were reviewed and categorized into four key themes: guidelines and algorithms for delivery of care; collaboration with patients and allied groups for care and education; registries for the monitoring of treatment and outcomes and health care planning and delivery; and opportunities for personalization of care...
August 3, 2018: Hematology (Amsterdam, Netherlands)
Hongyan Wang, Qiang Ding, Mingjun Wang, Mingwei Guo, Qi Zhao
BACKGROUND: Increasing evidence has suggested that miR-29b plays an antitumor effect in multiple malignancies via the regulation of cell proliferation, apoptosis, invasion and migration. In the present study, we aimed to explore the underlying function and mechanism of miR-29b in multiple myeloma (MM). METHODS: The expression of miR-29b in MM cell lines and tissues was detected by quantitative real-time PCR (qRT-PCR). CCK-8 and flow cytometry analyses were performed to assess cell proliferation, cycles and apoptosis...
August 1, 2018: Hematology (Amsterdam, Netherlands)
Pingli Yao, Xia He, Rong Zhang, Rongsheng Tong, Hongtao Xiao
OBJECTIVES: The effect of methotrexate (MTX)-related adverse reaction on hematologic neoplasms patients is controversial. We performed this meta-analysis to assess the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism and the adverse reaction after MTX using. METHODS: We searched for qualified studies according to PubMed, the Cochrane Library, and the Web of Science. The meta-analysis was performed by Review Manager 5.3. The analysis was conducted to compare risk ratios (RRs) with the corresponding 95% confidence interval (95% CI) to evaluate the relationship between different toxicity reactions and the genotype of MTHFR...
July 19, 2018: Hematology (Amsterdam, Netherlands)
José Carlos Jaime-Pérez, Goel Treviño-Reyna, Patrizia Aguilar-Calderón, Olga G Cantú-Rodríguez, Luis Javier Marfil-Rivera, David Gómez-Almaguer
OBJECTIVES: To demonstrate the importance of regional efforts to register features and report frequency of hematology diseases in the context of incomplete national registries. METHODS: Frequencies and salient characteristics of hematologic diseases in Northeast Mexico were documented in a reference center at a tertiary care university hospital during the decade 2005-2015. Disease categories were grouped by age, sex and diagnosis. Age group distribution followed WHO guidelines in years as children (0-17), adults (18-64) and elders (+65)...
July 16, 2018: Hematology (Amsterdam, Netherlands)
Sebaranjan Biswal, Huma Rizwan, Sweta Pal, Silpa Sabnam, Preetinanda Parida, Arttatrana Pal
BACKGROUND: The phenotypic expression of sickle cell disease (SCD) is a complex pathophysiologic condition. However, sickle erythrocytes might be the cause for multiple sources of pro-oxidant processes with consequent linked to chronic and systemic oxidative stress. Herein, we explored the SCD phenomena could be the result in formation of oxidative stress as well as inflammation in children. MATERIAL AND METHODS: Blood samples of 147 SCD subjects were evaluated...
July 16, 2018: Hematology (Amsterdam, Netherlands)
Junyue Fang, Li Lin, Ying Wang, Dijin Lin, Chunyue Liu, Qiaozi Sunlong, Xianghua Lin
OBJECTIVES: To investigate the immune status of children with very severe aplastic anemia (VSAA), and evaluate the frequencies of CD20+ B cells and Regulatory T cells (Tregs) as potential markers for evaluating the therapeutic efficacy and prognosis. METHODS: We systematically analyzed CD20+ B cells and Tregs using Flow Cytometry in 36 children with VSAA (14 newly diagnosed cases and 22 cases in remission after therapy with HDIVIG + r-ATG + CSA). RESULTS: In newly diagnosed VSAA patients, the percentage of CD20+ B cells was higher than that in healthy children (P < ...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Guray Saydam, Ibrahim Celalettin Haznedaroglu, Leylagul Kaynar, Akif S Yavuz, Ridvan Ali, Birol Guvenc, Olga M Akay, Zafer Baslar, Ugur Ozbek, Mehmet Sonmez, Demet Aydin, Mustafa Pehlivan, Bulent Undar, Simten Dagdas, Orhan Ayyildiz, Gülnur Akin, Ilkiz M Dag, Osman Ilhan
OBJECTIVES: This report presents final results (24 months of follow-up) from the first prospective, national study of frontline nilotinib in chronic myeloid leukemia (CML) patients in Turkey. METHODS: Patients with newly diagnosed Philadelphia chromosome-positive CML in chronic phase (CML-CP; N = 112) received nilotinib 300 mg twice daily. The primary endpoint, which was the cumulative rate of major molecular response (MMR; BCR-ABL1 ≤ 0.1% on the International Scale [BCR-ABL1IS ]) by 12 months, was previously reported (66...
July 11, 2018: Hematology (Amsterdam, Netherlands)
L De Roeck, L Michaux, K Debackere, E Lierman, P Vandenberghe, T Devos
OBJECTIVES: CML, PV, ET and PMF are so called classical MPN with distinct clinical phenotypes. The discovery of the BCR-ABL1 translocation and mutations in driver genes JAK2, MPL and CALR has provided novel insights in their pathogenesis. While these mutations are thought to be mutually exclusive, rare cases of MPN with coexisting driver mutations have been reported. However, little is known about the clinical, biological and molecular characteristics of these patients and the interaction of the neoplastic clones...
July 11, 2018: Hematology (Amsterdam, Netherlands)
Rungtip Putburee, Arunee Jetsrisuparb, Supan Fucharoen, Amporn Tripatara
BACKGROUND: Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress. Mitochondrial ferritin, encoded by the FTMT gene is an iron-storage protein in the mitochondria. The aim of this work was to investigate the expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia who were regularly transfused and rarely transfused compared with healthy controls and to evaluate the relationships of the levels of FTMT mRNA with malondialdehyde (MDA) and ferritin in these patients...
July 11, 2018: Hematology (Amsterdam, Netherlands)
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