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Hematology (Amsterdam, Netherlands)

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https://www.readbyqxmd.com/read/28914173/flow-cytometric-analysis-of-patients-with-hereditary-spherocytosis-an-indian-scenario
#1
Prabhu Manivannan, Seema Tyagi, Dinesh Chandra, Pravas Mishra, Hara Prasad Pati, Renu Saxena
OBJECTIVES: Flow cytometry osmotic fragility test (FC-OFT) was a recently introduced screening test for hereditary spherocytosis (HS). This study was conducted to evaluate the utility of FC-OFT in all newly diagnosed cases of HS, to compare its diagnostic value with conventional OFT and to correlate with clinical disease severity. METHODS: In this study, the percentage of residual red cells (%RRC) was measured using flow cytometer after creating a red cell suspension...
September 15, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28906207/high-absolute-basophil-count-is-a-powerful-independent-predictor-of-inferior-overall-survival-in-patients-with-primary-myelofibrosis
#2
Marko Lucijanic, Ana Livun, Tajana Stoos-Veic, Vlatko Pejsa, Ozren Jaksic, David Cicic, Jelena Lucijanic, Zeljko Romic, Biserka Orehovec, Gorana Aralica, Marko Miletic, Rajko Kusec
OBJECTIVES: To investigate the clinical and prognostic significance of absolute basophil count (ABC) in patients with primary myelofibrosis (PMF). METHODS: We retrospectively investigated 58 patients with PMF treated in our institution in the period from 2006 to 2017. ABC was obtained in addition to other hematological and clinical parameters. Patients were separated into high and low ABC groups using the Receiver operating characteristic curve analysis. RESULTS: ABC was higher in PMF patients than in healthy controls (P < 0...
September 14, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28902578/associations-between-the-hla-a-b-drb1-polymorphisms-and-aplastic-anemia-evidence-from-17-case-control-studies
#3
Xiao-Zhen Deng, Meng Du, Jiao Peng, Jian-Xiong Long, Cheng-Jun Zheng, Yuan Tan, Li-Juan Li, Hui-Ying Chen, Cao Qing, Yan-Yan Pang, Yan Lan, Hai-Tian Zhang
OBJECTIVE: To estimate the associations between HLA-A/B/DRB1 polymorphisms and aplastic anemia (AA), we carried out the meta-analysis. METHODS: In this meta-analysis, all publications in English and Chinese were considered up to 30 September 2015. The electronic databases we searched were Pubmed, Science Direct, Embase, Web of Science, CNKI, Wanfang Data and VIP. We conducted all statistical data analyses in the Stata11.0 software. RESULTS: A total of 17 studies including 9164 subjects (containing 1372 cases and 7792 controls) were retrieved, which studied the relationship between HLA-A/B/DRB1 and AA...
September 13, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28889783/sex-chromosome-changes-in-leukemia-cytogenetics-and-molecular-aspects
#4
Saeid Shahrabi, Elahe Khodadi, Fakhredin Saba, Mohammad Shahjahani, Najmaldin Saki
BACKGROUND AND OBJECTIVE: Sex chromosome loss (SCL) can occur in older men as a physiological phenomenon or as an acquired abnormality in leukemia. Loss of chromosome Y and loss of chromosome X are acquired disorders that are mainly observed in patients over 80 years as well as in myeloid and lymphoid malignancies. In this review, we examine the cytogenetic and molecular changes of sex chromosomes in leukemia. METHODS: Relevant English language literature were searched and retrieved from PubMed search engine (1990-2016)...
September 10, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28880742/decreased-levels-of-th17-cells-are-associated-with-invasion-fungal-infections-after-allogeneic-hematopoietic-stem-cell-transplantation
#5
Ling Wang, Peng Zhao, Chunlei Shi, Ying Li, Ketao Lan, Mingzhe Han
BACKGROUND: Delayed immune reconstitution is an important risk factor for increased susceptibility to fungal pathogens. However, little is known about the association between the recovery of CD4(+)T cell subsets and invasion fungal infections (IFIs) in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of the study was to analyze the immune reconstitution characteristics of CD4(+)T cell subsets and their association with the incidence of IFIs over the first 3 months after allo-HSCT...
September 7, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28876197/the-impact-of-flt3-mutations-on-treatment-response-and-survival-in-chinese-de%C3%A2-novo-aml-patients
#6
Qiao-Cheng Qiu, Chao Wang, Xie-Bing Bao, Jing Yang, Hong-Jie Shen, Zi-Xuan Ding, Hong Liu, Jun He, Hong Yao, Su-Ning Chen, Zheng Li, Sheng-Li Xue, Song-Bai Liu
OBJECTIVE: Two distinct forms of FMS-like tyrosine kinase 3 (FLT3) mutations, internal tandem duplication (ITD) in the juxtamembrane domain and point mutation within the activation loop of the tyrosine kinase domain (TKD), have been identified in considerable number of patients with AML. This study was aimed to analyze the impacts of these mutations on clinical outcomes, and assess the efficacy of different therapeutic regimens (allo-HSCT, sorafenib, or conventional chemotherapy) for AML patients with FLT3 mutations after the standard induction therapy...
September 6, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28856973/the-impact-of-fc-gamma-receptor-iia-and-iiia-gene-polymorphisms-on-the-therapeutic-response-of-rituximab-in-egyptian-adult-immune-thrombocytopenic-purpura
#7
Hend N Ellithy, Salwa H Ahmed, Gehan H Shahin, Mervat M Matter, Mohamed Talatt
BACKGROUND: In chronic immune thrombocytopenic purpura (ITP), rituximab removes the harmful autoantibodies through antibody-dependent cellular cytotoxicity. The response to rituximab in ITP is variable; the effectiveness of rituximab is influenced by the process of activation of effector fragment C gamma receptors (FcγRs). Genetic factors may affect the response to rituximab. OBJECTIVES: The influence of FcγRIIa (H131R) and FcγRIIIa (V158F) gene polymorphisms on the response to rituximab in ITP...
August 31, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28846064/challenges-in-the-management-of-sickle-cell-disease-during-pregnancy-in-senegal-west-africa
#8
Blaise Felix Faye, Kouassi Berenger Kouame, Moussa Seck, Abdou Aziz Diouf, Macoura Gadji, Nata Dieng, Sokhna Aissatou Touré, Abibatou Sall, Awa Oumar Toure, Saliou Diop
OBJECTIVES: The aim of this study was to evaluate the maternal and fetal complications in pregnant patients with sickle cell disease (SCD) and find risk factors of stillbirth. METHOD: We conducted a prospective study in pregnant women with SCD. Demographic characteristics, maternal and fetal morbi-mortality, and outcome of pregnancies were described. Risk factors of fetal loss were evaluated by comparing the parameters of the pregnancies that led to a live birth with those interrupted...
August 28, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28823228/can-biomarkers-of-coagulation-platelet-activation-and-inflammation-predict-mortality-in-patients-with-hematological-malignancies
#9
Shereef Elmoamly, Alaa Afif
BACKGROUND: Patients with cancer commonly demonstrate laboratory evidence for hypercoagulability. Coagulation and inflammation play a role in the pathophysiology of hematological malignancies and the correlation between hypercoagulability and inflammation with tumor outcomes and the patient's prognosis are well studied. OBJECTIVE: To identify an association between hemostasis activation, fibrinolysis and inflammation with mortality in patients with hematological malignancies to determine their prognostic significance...
August 20, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28823219/human-platelet-antigen-1-2-and-5-gene-polymorphisms-in-egyptians-and-their-potential-association-with-susceptibility-to-immune-thrombocytopenic-purpura-in-egyptian-patients
#10
Tayssir Kamel Eyada, Dalia Gamil Amin, Ihab Samih, Salwa Mohamed Khedr
OBJECTIVES: This study determined the incidence of HPA1, HPA2 and HPA5 polymorphisms in 120 Egyptian immune thrombocytopenic purpura (ITP) patients and 120 healthy Egyptian subjects. METHODS: Human platelet antigen (HPA) genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The frequency of HPA1 allele a and b was 78.75 and 21.25% in controls, 80.8 and 19.2% in ITP, respectively. HPA2 allele a and b frequency was 86...
August 20, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28795658/double-vs-single-cord-blood-transplantation-in-adolescent-and-adult-hematological-malignancies-with-heavier-body-weight-%C3%A2-50%C3%A2-kg
#11
Chang-Cheng Zheng, Xiao-Yu Zhu, Bao-Lin Tang, Xu-Han Zhang, Lei Zhang, Liang-Quan Geng, Hui-Lan Liu, Zi-Min Sun
BACKGROUND: Double-unit cord blood transplantation (CBT) can be used to overcome the limitation of single-unit CBT with low cell content for adults and larger adolescents. However, whether double-unit CBT is superior to single-unit CBT remains controversial. METHODS: We reviewed the medical records of 228 consecutive hematological malignancies who received CBT between November 2005 and December 2013. Ninety-seven eligible patients met the criteria (age ≥14 years and body weight ≥50kg) and were enrolled in this study...
August 10, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28768465/interaction-between-hb-e-and-hb-yala-hbb-c-129delt-a-novel-frameshift-beta-globin-gene-mutation-resulting-in-hemoglobin-e-%C3%AE-0-thalassemia
#12
Supachai Ekwattanakit, Suchada Riolueang, Vip Viprakasit
OBJECTIVES: There are more than 200 known mutations found in patients with β-thalassemia, a possibility to identify an unknown or novel mutation becomes less possible. Here, we report a novel mutation in a patient from Thailand who presented with chronic hemolytic anemia. METHODS: A comprehensive hematology and DNA analysis was applied in the index patient and her mother. RESULTS: Hematological and hemoglobin analyses were consistent with the clinical diagnosis of Hb E/β(0)-thalassemia...
August 3, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28766464/stigma-and-illness-uncertainty-adding-to-the-burden-of-sickle-cell-disease
#13
Alphanso Blake, Vikram Asnani, Robin R Leger, June Harris, Victoria Odesina, Jennifer Knight-Madden, Linda Wagner, Monika Rani Asnani
BACKGROUND: Persons with sickle cell disease (SCD) experience multiple medical and physical complications; the disease also has numerous effects on their social and emotional well-being. We hypothesized that adults with SCD in Jamaica experience moderate levels of stigma and illness uncertainty and that these experiences may be associated with socio-demographic factors, such as gender, educational status and economic status. METHODS: We surveyed 101 adults with SCD (54...
August 2, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28762299/congenital-prothrombin-defects-they-are-not-only-associated-with-bleeding-but-also-with-thrombosis-a-new-classification-is-needed
#14
Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, Bruno Girolami, Anna Maria Lombardi
OBJECTIVE: Congenital prothrombin deficiency is one of the rarest clotting disorders. It is commonly subdivided in Type I defects or cases of 'true' prothrombin deficiency characterized by a concomitant decrease in FII activity and antigen and in Type II or dysprothrombinemias, in which FII activity is low but FII antigen is normal or near normal. A bleeding tendency, often a severe one, is the hallmark of the two-defects even though the bleeding is usually less severe in the Type 2 defects or dysprothrombinemias...
August 1, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28759343/epidemiologic-study-of-major-complications-in-adolescent-and-adult-patients-with-thalassemia-in-northeastern-thailand-the-e-saan-study-phase-i
#15
Nattiya Teawtrakul, Arunee Jetsrisuparb, Saranya Pongudom, Chittima Sirijerachai, Kanchana Chansung, Chinadol Wanitpongpun, Supan Fucharoen
INTRODUCTION: Thalassemia-related complications are one of the main factors that increase morbidity and mortality in aging patients with thalassemia. This study was aimed to report the prevalence and clinical risk factors for the complications in thalassemia. METHODS: A multi-center prospective cohort study was conducted in patients with thalassemia aged ≥10 years old. Thalassemia-related complications were heart failure, pulmonary hypertension, extramedullary hematopoiesis, endocrine disorders, infections, thrombosis and leg ulcers...
July 31, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28728506/microsatellite-instability-and-promoter-hypermethylation-of-dna-repair-genes-in-hematologic-malignancies-a-forthcoming-direction-toward-diagnostics
#16
Priyanjali Bhattacharya, Trupti N Patel
OBJECTIVE: The objective of our review is to highlight the significance of microsatellite hypervariation in diagnostics of hematologic malignancies. METHODS: For the past few decades, extensive experiments in cancer research have explored all the possible pathways and a number of deleterious mutations that either make the tumor suppressor genes (TSGs) dysfunctional or cause the proto-oncogenes to behave abnormally by changing the cellular phenotype hence rendering disease...
July 20, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28718348/thalidomide-has-a-significant-effect-in-patients-with-thalassemia-intermedia
#17
YunShuan Li, Quan Ren, Yali Zhou, Pingping Li, Wanhua Lin, Xiaolin Yin
OBJECTIVE: To investigate the effect of thalidomide in patients with thalassemia intermedia. METHODS: We observed the effect of thalidomide in seven patients with thalassemia intermedia requiring blood transfusion. Four of the patients were transfusion-independent, and three patients were transfusion-dependent. RESULTS: For the four transfusion-independent patients, hemoglobin concentration increased significantly (≥2 g/dl) in three and moderately (1-2 g/dl) in one...
July 18, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28675126/characteristics-of-bone-marrow-cell-dysplasia-and-its-effectiveness-in-diagnosing-myelodysplastic-syndrome
#18
Chujia Liang, Junxun Li, Jing Cheng, Shaoqian Chen, Zhuangjian Ye, Fan Zhang, Zhe Wang, Fang Wang, Cheng Peng, Juan Ouyang
BACKGROUND: Although dysplasia plays an important role in the diagnosis of myelodysplasia syndrome (MDS), its morphologic variety and irregularity result in difficulties in its clinical application. METHODS: Bone marrow smears from cases with MDS and non-clonal disease were collected and performed microscopy analysis. We respectively recorded the percentage of specific dysplastic cells (PSDC) and incidence of specific dysplasia (ISD) of each dysplastic type in three hematopoietic cell lineages for the comprehensive analysis of diagnostic efficacy to MDS...
July 4, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28651453/pretransplant-serum-ft3-levels-in-recipients-predict-early-non-relapse-mortality-after-myeloablative-allogeneic-haematopoietic-cell-transplantation-from-matched-sibling-donors
#19
Huijuan Li, Jia Chen, Bimin Shi, Xingbo Chen, Depei Wu, Ying Wang
OBJECTIVES: Although decreased thyroid function is negatively correlated with clinical outcomes in critically ill patients, its role in allogeneic haematopoietic cell transplantation (allo-HCT) has not been sufficiently described. METHODS: The associations between pre-conditioning thyroid hormone concentrations and transplant-related complications in 474 adult patients with haematologic malignancies who underwent myeloablative allo-HCT were assessed. RESULTS: A receiver-operating characteristic curve showed that the baseline serum-free triiodothyronine 3 (FT3) level had an excellent predictive value for non-relapse mortality (NRM) within 100 days in sibling HCT with an area under the curve of 0...
June 26, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28463078/analysis-of-clinical-characteristics-and-prognostic-factors-of-multiple-myeloma-a-retrospective-single-center-study-of-787-cases
#20
Jiejing Qian, Jie Jin, Hong Luo, Chunji Jin, Lei Wang, Wenbin Qian, Haitao Meng
OBJECTIVE: This study aims to explore the clinical features of multiple myeloma (MM) and the influence of various prognostic factors on survival. METHODS: A retrospective analysis, consisting of clinical characteristics analysis and laboratory examinations, was performed on 787 MM patients. Clinical and laboratory parameters were analyzed by multivariate process and compared across different groups. RESULTS: Of the 787 patients enrolled (median age, 61 years old, range 29-89 years old), 491 (62...
September 2017: Hematology (Amsterdam, Netherlands)
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