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Journals Hematology (Amsterdam, Netherl...

Hematology (Amsterdam, Netherlands)

https://read.qxmd.com/read/38536023/tim3-and-ctla4-immune-checkpoint-polymorphisms-are-associated-with-acute-myeloid-leukemia-in-saudi-arabia
#1
JOURNAL ARTICLE
Mashael Alqahtani, Ali Aljuaimlani, Jameel Al-Tamimi, Suliman Alomar, Lamjed Mansour
BACKGROUND: Immune checkpoints are receptors on the surface of T cells that function crucially in suppressing the immune response, and they are implicated in autoimmunity and cancer diseases. AIM: The present study aimed to investigate the relationship between functional single nucleotide polymorphisms (SNPs) of two immune checkpoint molecules, CTLA-4 and TIM-3, and acute myeloid leukemia (AML) in a Saudi population. METHODS: Two SNPs in CTLA-4 (rs231775, A > G) and TIM-3 (rs10515746, A > C) were genotyped in 229 subjects, including 98 patients and 131 healthy controls, from the Saudi population using TaqMan assay methods...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38526293/endari-treatment-ameliorates-sickle-cell-related-disruption-in-intestinal-barrier-functions-and-is-associated-with-prolonged-survival-in-sickle-cell-mice
#2
JOURNAL ARTICLE
Elio Haroun, Seah H Lim, Dibyendu Dutta
BACKGROUND: Endari (L-glutamine) is a conditional amino acid that reduces the frequency of vaso-occlusive crisis (VOC) in sickle cell disease (SCD). AIM: To investigate whether Endari could ameliorate intestinal barrier function and improve survival outcomes in SCD. METHODS: We treated female Townes SCD mice with Endari and evaluated their intestinal barrier functions by measuring the recovery of orally administered fluorescein isothiocyanate (FITC)-conjugated dextran 4 kDa in serum, and serum intestinal fatty acid binding proteins (iFABP) and lipopolysaccharide (LPS) concentrations by ELISA...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38526239/outcomes-and-adverse-events-in-older-acute-lymphoblastic-leukemia-patients-treated-with-a-pediatric-inspired-protocol-with-pegylated-or-native-asparaginase
#3
JOURNAL ARTICLE
Maria Agustina Perusini, Claire Andrews, Eshetu G Atenafu, Vikas Gupta, Dawn Maze, Andre C Schuh, Karen Wl Yee, Aniket Bankar, Marta B Davidson, Guillaume Richard-Carpentier, Steven M Chan, Jad Sibai, Aaron D Schimmer, Mark D Minden, Hassan Sibai
This retrospective report presents the outcomes and adverse events (AEs) observed in 73 patients aged 60 years or older diagnosed with Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia (Ph-negative ALL) treated with a pediatric-inspired protocol incorporating either Pegylated (PEG-ASP) or Native Asparaginase (EC-ASP). Notably, 61% of patients experienced AEs of Grade III-IV severity. The most prevalent AEs included thrombosis (35.6%), febrile neutropenia (38.4%), and transaminitis (34.2%). AEs did not translate into significant differences concerning overall survival, leukemia-free survival, or early mortality...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38511647/down-regulation-of-a20-mrna-expression-in-peripheral-blood-mononuclear-cells-from-mds-patients
#4
JOURNAL ARTICLE
Kai Wang, Tianyu Si, Congmin Wei, Qi Hu, Yongming Zhou, Jizhang Bao
Myelodysplastic syndrome (MDS) is characterized by activated inflammatory signaling and affects prognosis. Targeting inflammatory signaling may provide a way to treat the disease. We were curious whether there were changes in A20 in peripheral blood mononuclear cells (PBMC) of MDS patients. Therefore, we conducted a study with 60 clinical samples, including 30 MDS patients and 30 healthy controls. All patients with MDS were diagnosed and classified according to the criteria of the 2016 World Health Organization...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38511645/current-status-of-conditioning-regimens-in-haploidentical-hematopoietic-cell-transplantation
#5
REVIEW
Junichi Sugita, Masamitsu Yanada
The development of effective prophylaxis strategies against graft-versus-host disease (GVHD) has contributed to the widespread use of haploidentical related hematopoietic cell transplantation (Haplo-HCT). Currently, GVHD prophylaxis containing posttransplant cyclophosphamide (PTCY) is considered the standard of care in Haplo-HCT, and recent studies have shown comparable results for PTCY-based Haplo-HCT and HCT from other donor sources. The conditioning regimen plays an important role in eradicating tumor cells to prevent disease relapse and suppressing the recipient's immune system to facilitate engraftment...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38511642/phf19-before-and-post-induction-treatment-possess-favorable-potency-of-reflecting-treatment-response-to-protease-inhibitors-event-free-survival-and-overall-survival-in-multiple-myeloma-patients
#6
JOURNAL ARTICLE
Hongyu An, Shiming Chen, Xin Zhang, Shandong Ke, Jinyong Ke, Yalan Lu
OBJECTIVE: Plant homeodomain finger protein 19 (PHF19) regulates hematopoietic stem cell differentiation and promotes multiple myeloma (MM) progression. This study intended to explore the potency of PHF19 at baseline and post induction treatment in estimating treatment response to protease inhibitors and survival in MM patients. METHODS: This retrospective study screened 69 MM patients who received protease inhibitors with bone marrow (BM) samples available at both baseline and post induction treatment...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38511641/lsp1-promotes-the-progression-of-acute-myelogenous-leukemia-by-regulating-ksr-erk-signaling-pathway-and-cell-migration
#7
JOURNAL ARTICLE
Tan Li, Xiaochen Gui, Bin Li, Xueying Hu, Yuanyin Wang
We aimed to investigate the role and mechanism of LSP1 in the progression of acute myelogenous leukemia. In this study, we established shLSP1 cell line to analyze the function of LSP1 in AML. We observed high expression of LSP1 in AML patients, whereas it showed no expression in normal adults. Furthermore, we found that LSP1 expression was associated with disease prognosis. Our results indicate that LSP1 plays a crucial role in mediating proliferation and survival of leukemia cells through the KSR/ERK signaling pathway...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38488443/construction-and-validation-of-an-18-f-fdg-pet-ct-based-prognostic-model-to-predict-progression-free-survival-in-newly-diagnosed-multiple-myeloma-patients
#8
JOURNAL ARTICLE
Xiaoqing Dong, Ruoyi Wang, Xiuhua Ying, Jiaxuan Xu, Jie Yan, Peipei Xu, Yue Peng, Bing Chen
OBJECTIVE: To investigate the relationship between 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) related parameters and the prognosis of multiple myeloma and to establish and validate a prediction model regarding the progression-free survival (PFS) of multiple myeloma. METHODS: A retrospective analysis of 126 newly diagnosed multiple myeloma patients who attended Nanjing Drum Tower Hospital from 2014-2021. All patients underwent PET/CT before treatment and were divided into a training cohort ( n  = 75) and a validation cohort ( n  = 51)...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38470208/severe-and-continuous-immunoparesis-during-induction-or-maintenance-therapy-in-nontransplant-patients-with-multiple-myeloma-is-a-sign-of-poor-prognosis
#9
JOURNAL ARTICLE
Ying Chen, Zhe Chen, Junjie Cao, Li Lin, Jipeng Li
OBJECTIVE: Multiple myeloma (MM) varies in clinical behavior, response to treatment and prognosis due to the heterogeneity of the disease. Data on the association between the immunoparesis status during treatment and prognosis in nontransplant MM patients are limited. METHODS: In a retrospective analysis of 142 patients with MM, we examined the relationship between immunoparesis status and prognosis during treatment. All patients received novel agent-based therapy and did not undergo autologous stem cell transplantation...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38466633/dioscin-alleviates-aplastic-anemia-through-regulatory-t-cells-promotion
#10
JOURNAL ARTICLE
Liwei Fan, Runfeng Ni, Haijin Wang, Le Zhang, Aidi Wang, Baoshan Liu
Objectives: Aplastic anemia (AA) is one of the immune-mediated bone marrow failure disorders caused by multiple factors, including the inability of CD4 + CD25 + regulatory T cells (Tregs) to negatively regulate cytotoxic T lymphocytes (CTLs). Dioscin is a natural steroid saponin that has a similar structure to steroid hormones. The purpose of this study is to look into the effect of Dioscin on the functions of CD4 + CD25+ Tregs in the AA mouse model and explore its underlying mechanism. Methods: To begin with, bone marrow failure was induced through total body irradiation and allogeneic lymphocyte infusion using male Balb/c mice...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38465661/pre-treatment-18-f-fdg-pet-ct-for-assessing-bone-marrow-involvement-and-prognosis-in-patients-with-newly-diagnosed-peripheral-t-cell-lymphoma
#11
JOURNAL ARTICLE
Jing Chen, Yi Zhao
PURPOSE: To explore the value of [18 F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in assessing bone marrow involvement (BMI) and prognosis in newly diagnosed peripheral T-cell lymphomas (PTCLs) before treatment. METHODS: This retrospective study included 201 eligible PTCLs who received pre-bone marrow biopsy (BMB) and PET/CT. The status of bone marrow (BM) by PET was assessed using a visual examination and a quantitative index (the maximal standardized uptake value [SUVmax ] of BM divided by the SUVmax of the liver [M/L])...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38445826/an-observational-study-of-haemophilia-a-patients-without-inhibitors-using-the-french-national-claims-snds-database
#12
JOURNAL ARTICLE
Marc Trossaërt, Aletta Falk, Laurène Gautier, Nana Kragh, Olivia Van Hinloopen, Remi Varin
OBJECTIVES: To describe clinical characteristics, factor consumption, and events of interest in patients with haemophilia A without inhibitors receiving prophylaxis in France, and the clinical impact of switching to Elocta® in this population. METHODS: This retrospective, observational study using the Système National des Données de Santé database, analysed data from patients with haemophilia A without inhibitors using prophylactic factor VIII (FVIII) replacement therapy during 2016-2019...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38433437/prognostic-analysis-according-to-european-leukemianet-2022-risk-stratification-for-elderly-patients-with-acute-myeloid-leukemia-treated-with-decitabine
#13
JOURNAL ARTICLE
Mihee Kim, Seo-Yeon Ahn, TaeHyung Kim, Sung-Hoon Jung, Ga-Young Song, Deok-Hwan Yang, Je-Jung Lee, Mi Yeon Kim, Ju Heon Park, Myung-Geun Shin, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim
OBJECTIVES: This study aimed to evaluate the prognostic significance of the revised European LeukemiaNet (ELN)-2022 risk stratification model for 123 elderly acute myeloid leukemia (AML) patients treated with decitabine chemotherapy. RESULTS: Based on the ELN-2022 risk stratification, 15 (12.2%), 51 (41.5%), and 57 (46.3%) patients were classified as having favorable, intermediate, and high-risk AML, respectively. In comparison with the ELN-2017 risk stratification, the ELN-2022 risk stratification re-assigned 26 (21...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38433435/hub-genes-and-associated-drugs-for-multiple-myeloma-with-1q21-identified-by-bioinformatic-analysis
#14
JOURNAL ARTICLE
Zhiqiang Xu, Jieni Yu, Yamei Chen
While 1q21+ was common genetic alteration and found to have adverse effect on prognosis, the underlying genes remain unclear. Identification of related genes may provide additional help for rational intervention. The microarray dataset GSE2658 associated with MM was downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were obtained, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to annotate their functions...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38407192/cytomegalovirus-immunoglobulin-serology-prevalence-in-patients-with-newly-diagnosed-multiple-myeloma-treated-within-the-gmmg-mm5-phase-iii-trial
#15
JOURNAL ARTICLE
Hans Salwender, Niels Weinhold, Axel Benner, Kaya Miah, Maximilian Merz, Mathias Haenel, Christian Jehn, Elias Mai, Ekaterina Menis, Igor Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Steffen Luntz, Britta Besemer, Markus Munder, Peter Brossart, Bertram Glass, Hans-Walter Lindemann, Katja Weisel, Christine Hanoun, Paul Schnitzler, Sarah Klemm, Hartmut Goldschmidt, Marc Raab, Ahmet Elmaagacli
OBJECTIVES: The seroprevalence of antibodies against Cytomegalovirus (CMV) is an established poor prognostic factor for patients receiving an allogeneic stem cell transplantation. However, the impact of CMV serology on outcome after autologous stem cell transplantation remains unknown. METHODS: Here, we analyzed the CMV immunoglobulin (Ig) serology of 446 newly-diagnosed multiple myeloma (MM) patients of the GMMG-MM5 phase III trial with a median follow-up of 58 months...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38376107/real-world-long-term-safety-and-effectiveness-of-turoctocog-alfa-in-the-treatment-of-haemophilia-a-in-japan-results-from-a-multicentre-non-interventional-post-marketing-study
#16
JOURNAL ARTICLE
Azusa Nagao, Ayumi Deguchi, Keiji Nogami
OBJECTIVES: To assess the safety and effectiveness of turoctocog alfa in previously treated patients (PTPs) and previously untreated patients (PUPs) with haemophilia A in a real-world setting in Japan. METHODS: This multicentre, non-interventional, post-marketing study recruited patients with haemophilia A who initiated treatment with turoctocog alfa from 18 sites (08/2014-12/2018). The primary endpoint was adverse events (AEs) during the 2-year study period. RESULTS: The safety and effectiveness analysis set included 39 patients...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38346146/the-influence-of-dead-space-in-blood-sampling-needle-on-fviii-level-and-pharmacokinetic-profiles-in-children-with-hemophilia
#17
JOURNAL ARTICLE
Yingzi Zhen, Di Ai, Kun Huang, Gang Li, Zhenping Chen, Runhui Wu
OBJECTIVE: To investigate the influence of the dead space in disposable blood sampling needle on activated partial thromboplastin time (APTT), FVIII level and pharmacokinetic (PK) profiles in children with hemophilia. METHODS: Children (<18 years) with severe hemophilia A were enrolled. After three days' washout-period, blood samples were collected at pre-dose, 1 h, 3 h, 9 h, 24 h and 48 h post-infusion. At each timepoint, two 2 mL vacuum tubes with 3...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38332700/more-about-post-transplant-cyclophosphamide-in-haploidentical-grafts-full-or-reduced-doses
#18
JOURNAL ARTICLE
Moisés Manuel Gallardo-Pérez, César Homero Gutiérrez-Aguirre, Juan Carlos Olivares-Gazca, Guillermo José Ruiz-Argüelles
Haploidentical hematopoietic can be conducted on an outpatient basis but the two main reasons to accept into the hospital a patient in this setting are complications of the hematological toxicity and/or the cytokine-release syndrome. With the aim of reducing the post-transplant cyclophosphamide-dependent toxicity without compromising its effectivity, attempts to reduce the dose of post-transplant cyclophosphamide have been made: Decreases from the conventional total dose of post-transplant cyclophosphamide (100 mg/Kg) have been explored worldwide, showing that decreasing the total dose to even 50 mg/Kg significantly decreases the toxicity of the procedure without compromising its efficacy, safety and results...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38329272/renal-outcome-in-multiple-myeloma-patients-with-cast-nephropathy-a-retrospective-analysis-of-potential-predictive-values-on-clinical-and-renal-outcome
#19
JOURNAL ARTICLE
Lina Z Rüsing, Nicolas Kozakowski, Georg Jeryczynski, Lea Vospernik, Julia Riedl, Thomas Reiter, Heinz Gisslinger, Hermine Agis, Maria-Theresa Krauth
OBJECTIVE: Cast nephropathy (CN) is the leading cause of acute kidney injury (AKI) in multiple myeloma (MM). Since it is sparsely documented why some patients with CN do achieve a renal response while others do not, we describe a single-center cohort of patients with multiple myeloma and biopsy-confirmed CN to evaluate potential markers of renal response. METHODS: The data was collected as a retrospective, single-center analysis of CN-patients treated at the Medical University Vienna between 01/01/2004 and 01/01/2022...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38326994/correction
#20
JOURNAL ARTICLE
(no author information available yet)
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December 2024: Hematology (Amsterdam, Netherlands)
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