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Scandinavian Cardiovascular Journal: SCJ

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https://www.readbyqxmd.com/read/29893146/circulating-endostatin-and-the-incidence-of-heart-failure
#1
Toralph Ruge, Axel C Carlsson, Erik Ingelsson, Ulf Risérus, Johan Sundström, Anders Larsson, Lars Lind, Johan Ärnlöv
OBJECTIVE: Circulating levels of endostatin are elevated in many underlying conditions leading to heart failure such as hypertension, diabetes, chronic kidney disease and ischemic heart disease. Yet, the association between endostatin and the incidence of heart failure has not been reported previously in the community. DESIGN: We investigated the longitudinal association between serum endostatin levels and incident heart failure in two community-based cohorts of elderly: Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 966; mean age 70 years, 51% women, 81 events, mean follow-up 10 years) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 747 men; mean age 78 years, 98 heart failure events, mean follow-up 8 years)...
June 12, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29842807/dabigatran-affects-thrombin-dependent-platelet-aggregation-after-a-week-long-therapy
#2
Juraj Sokol, Frantisek Nehaj, Jela Ivankova, Michal Mokan, Marian Mokan, Jan Stasko
OBJECTIVE: Dabigatran is a direct thrombin inhibitor. As the main adverse event is bleeding, it is relevant whether dabigatran has additional effects on platelet function. If so, it could affect the bleeding risk. We aimed to assess in vitro aggregation in patients with atrial fibrillation (AF) receiving dabigatran. DESIGN: We evaluated 32 AF patients treated with dabigatran (study group) and 18 non-anticoagulated non-AF blood donors (control group). We assessed light transmittance platelet aggregation (LTA) with 100 nmol/L γ-thrombin in both groups...
August 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29798684/effects-of-antiarrhythmics-and-hypokalemia-on-the-rate-adaptation-of-cardiac-repolarization
#3
Oleg E Osadchii
OBJECTIVES: In normal conditions, sudden heart rate acceleration provokes a rapid reduction in ventricular action potential duration (APD). The protracted APD rate adaptation favors early afterdepolarizations and precipitates arrhythmia. Nevertheless, it is uncertain as to whether the rate-dependent changes of ventricular repolarization can be adversely modified by arrhythmogenic drugs (quinidine and procainamide) and hypokalemia, in comparison to the agents with safe therapeutic profile, such as lidocaine...
August 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29671629/impaired-left-ventricular-filling-is-associated-with-decreased-pulse-oximetry-values
#4
Lene Gjelseth Dalbak, Henrik Schirmer, Jørund Straand, Ibrahimu Mdala, Ole Geir Solberg, Hasse Melbye
OBJECTIVES: The aim of this study was to investigate the association between echocardiographic measures of diastolic left ventricular dysfunction and decreased arterial oxyhaemoglobin saturation measured with pulse oximetry (SpO2 ). DESIGN: This is a cross-sectional population-based survey of Norwegian adults. Values obtained using echocardiography, pulse oximetry, and spirometry were included. The primary outcome was abnormal mitral Doppler inflow, defined as normal: E/A ratio 0...
August 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29571268/correction-to-janiec-et-al-graft-failure-and-recurrence-of-symptoms-after-coronary-artery-bypass-grafting
#5
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29569500/mechanisms-of-action-and-clinical-use-of-specific-reversal-agents-for-non-vitamin-k-antagonist-oral-anticoagulants
#6
Kristoffer Andresen, Dan Atar, Erik Gjertsen, Waleed Ghanima, Svein Roseth, Odd Erik Johansen
OBJECTIVES: With a steadily growing number of patients with non-valvular atrial fibrillation, anticoagulation use increases. Anticoagulation therapy is associated with increased risk of serious bleeding and an increased complexity in management of patients in need for urgent surgery. We wanted to assess the magnitude of this challenge as well as review current and potential future clinical management strategies. DESIGN: A review of the literature on the magnitude of patients using antigoaculants in potential need for acute restoration of hemostasis was conducted, as well as current status of reversal agents for non-vitamin K antagonist oral anticoagulants (NOACs)...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29566572/effects-of-endothelin-1-on-intracellular-tetrahydrobiopterin-levels-in-vascular-tissue
#7
Ruha Cerrato, Mark Crabtree, Charalambos Antoniades, Karolina Kublickiene, Ernesto L Schiffrin, Keith M Channon, Felix Böhm
OBJECTIVE: Tetrahydrobiopterin (BH4) is the essential cofactor of endothelial nitric oxide synthase (eNOS) and intracellular levels of BH4 is regulated by oxidative stress. The aim of this paper was to describe the influence of exogenous endothelin-1 on intracellular BH4 and its oxidation products dihydrobiopterin (BH2) and biopterin (B) in a wide range of vascular tissue. DESIGN: Segments of internal mammary artery (IMA) and human saphenous vein (SV) from 41 patients undergoing elective surgery were incubated in ET-1 (0...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29564930/temporal-variation-in-out-of-hospital-cardiac-arrest-with-validated-cardiac-cause
#8
Tim Jallow, Patrik Wennberg, Ann-Sofie Forslund
OBJECTIVE: Temporal variations in the occurrence of out-of-hospital cardiac arrest (OHCA) have been shown. Most previous studies have in common that they include individuals whom have received cardiopulmonary resuscitation (CPR) and thus excluding a great number of all the actual cases of OHCA when conducting a study. Therefore the aim of this study was to describe temporal variations of OHCA, regardless of whether CPR was performed or not. DESIGN: All individuals aged 25-74 years in northern Sweden, 1989-2009, who suffered an out-of-hospital cardiac arrest with validated myocardial infarction aetiology (OHCA-V), regardless of whether CPR was performed or not, were included in this study, which resulted in 3357 individuals...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29553891/importance-of-comorbidities-in-comatose-survivors-of-shockable-and-non-shockable-out-of-hospital-cardiac-arrest-treated-with-target-temperature-management
#9
Idrees Salam, Jakob Hartvig Thomsen, Jesper Kjaergaard, John Bro-Jeppesen, Martin Frydland, Matilde Winther-Jensen, Lars Køber, Michael Wanscher, Christian Hassager, Helle Søholm
OBJECTIVE: Comorbidity prior to out-of-hospital cardiac arrest (OHCA) and primary rhythm in relation to survival is not well established. We aimed to assess the prognostic importance of comorbidity in relation to primary rhythm in OHCA-patients treated with Target Temperature Management (TTM). DESIGN: Consecutive comatose survivors of OHCA treated with TTM in hospitals in the Copenhagen area between 2002-2011 were included. Utstein-based pre- and in-hospital data collection was performed...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29544374/synthetic-late-gadolinium-enhancement-cardiac-magnetic-resonance-for-diagnosing-myocardial-scar
#10
Goran Abdula, Jannike Nickander, Peder Sörensson, Magnus Lundin, Peter Kellman, Andreas Sigfridsson, Martin Ugander
OBJECTIVES: Late gadolinium enhancement (LGE) is the in vivo reference standard for assessing focal myocardial fibrosis. Post-contrast T1-mapping by Modified Look-Locker Inversion recovery (MOLLI) can be used to generate synthetic late gadolinium enhancement (SynLGE) images with an image contrast similar to conventional LGE images. We hypothesized that SynLGE has an accuracy that approaches conventional LGE for diagnosing focal myocardial fibrosis. METHODS: Consecutive patients (n = 109, mean ± SD age 50 ± 16 years, 63% male) referred for clinical cardiac magnetic resonance imaging underwent LGE and post-contrast MOLLI starting 10-15 and 20-25 minutes post contrast, respectively...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29544369/comparison-of-three-haemodynamic-monitoring-methods-in-comatose-post-cardiac-arrest-patients
#11
Henrik Staer-Jensen, Kjetil Sunde, Espen Rostrup Nakstad, Jan Eritsland, Geir Øystein Andersen
OBJECTIVES: Haemodynamic monitoring during post arrest care is important to optimise treatment. We compared stroke volume measured by minimally-invasive monitoring devices with or without thermodilution calibration, and transthoracic echocardiography (TTE), and hypothesised that thermodilution calibration would give stroke volume index (SVI) more in agreement with TTE during targeted temperature management (TTM). DESIGN: Comatose out-of-hospital cardiac arrest survivors receiving TTM (33 °C for 24 hrs) underwent haemodynamic monitoring with arterial pulse contour analyses with (PiCCO2®) and without (FloTrac® /Vigileo® monitor® ) transpulmonary thermodilution calibration...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29537317/atrio-ventricular-junction-ablation-and-pacemaker-treatment-a-comparison-between-men-and-women
#12
Carina Carnlöf, Per Insulander, Mats Jensen-Urstad, Marie Iwarzon, Fredrik Gadler
OBJECTIVES: To explore sex differences regarding indication for atrio-ventricular junction ablation (AVJ), choice of pacing system, complications to pacemaker treatment, long-term outcome, and cause of death after AVJ ablation. DESIGN: 700 patients who had undergone AVJ ablation between January 1990 and December 2010 were included. Data were retrieved from the patients´ medical records and the Swedish Pacemaker and Implantable Cardioverter-Defibrillator Registry...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29508655/graft-failure-and-recurrence-of-symptoms-after-coronary-artery-bypass-grafting
#13
Mikael Janiec, Timo Z Nazari Shafti, Axel Dimberg, Bo Lagerqvist, Rickard P F Lindblom
OBJECTIVES: Saphenous vein grafts (SVGs) most often used in coronary artery bypass grafting (CABG) are subject to graft disease and have poor long-term patency, however the clinical implication of this is not completely known. We aim to assess the influence of graft failure on the postoperative recurrence of coronary artery disease (CAD) symptoms in relation to the contribution from progression of atherosclerosis in the native coronary vessels. DESIGN: Within the SWEDEHEART registry we identified 46,663 CABG cases between 2001 and 2015 with patient age 40-80 years where single internal mammary artery (IMA) anastomosis (IMA), single IMA with one (1SVG) or multiple SVG anastomoses (2+ SVG) had been performed...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29460660/early-repolarization-pattern-in-the-coronary-slow-flow-phenomenon
#14
Murat Sucu, Berzal Ucaman, Gökhan Altunbas
BACKGROUND: The coronary slow flow phenomenon (CSFP) is well-documented, and the early repolarization pattern (ERP) has recently been shown to be a risk factor for the development of malignant ventricular arrhythmias. METHODS: Those with true CSFP were included as cases and those with normal angiograms were included as controls. We assessed J-point elevation on surface electrocardiograms (ECGs) and defined ERP as notching or slurring of the terminal portion of the QRS takeoff...
June 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29668339/in-hospital-outcomes-after-rotational-atherectomy-in-patients-with-low-ejection-fraction
#15
Yusuke Watanabe, Toru Naganuma, Hiroyoshi Kawamoto, Hisaaki Ishiguro, Sunao Nakamura
OBJECTIVES: This study evaluated angiographic success and in-hospital outcomes of percutaneous coronary intervention (PCI) with rotational atherectomy (RA) in patients with low left ventricular ejection fraction (LVEF). DESIGN: Between January 2010 and March 2014, 272 consecutive patients with heavily calcified lesions underwent elective PCI with RA. Of these, 33 patients had LVEF ≤35% (low LVEF group), whereas 237 patients had LVEF >35% (preserved LVEF group)...
April 18, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29656687/longitudinal-evaluation-of-ventricular-ejection-fraction-and-nt-probnp-across-heart-failure-subgroups
#16
Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J Gustav Smith
OBJECTIVES: Left ventricular ejection fraction (EF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are important surrogate markers of cardiac function and wall stress. Randomized trials of heart failure (HF) have shown improvements in survival in patients with reduced EF (<40%, HFrEF) but not with preserved EF (≥50%, HFpEF) or mid-range EF (40-49%, HFmrEF). Limited information is available on the trajectory of EF in contemporary heart failure management programs (HFMPs)...
April 14, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29652185/the-a%C3%A2-velocity-in-the-tissue-doppler-predicts-s-d-ratio-1-in-patients-with-a-normal-ejection-fraction
#17
Benny Johansson, Fredrik Lundin, Rolf Tegeback, Leif Bojö
OBJECTIVES: To compare the ability of the a´ velocity and the e´ velocity in predicting a dominant diastolic pulmonary vein flow (S/D ratio <1) in patients with normal ejection fraction. DESIGN: We retrospectively evaluated the diastolic function according to the ASE/EACVI guidelines, the S/D ratio and the septal, lateral and average a´ velocity in 293 unselected in-hospital patients, aged 39-86 years, in sinus rhythm and with no or mild valve disease, having a normal systolic function (EF >50%)...
April 13, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29648475/alterations-in-plasma-l-arginine-and-methylarginines-in-heart-failure-and-after-heart-transplantation
#18
Jakob Lundgren, Anna Sandqvist, Mikael Hedeland, Ulf Bondesson, Gerhard Wikström, Göran Rådegran
OBJECTIVE: Endothelial function, including the nitric oxide (NO)-pathway, has previously been extensively investigated in heart failure (HF). In contrast, studies are lacking on the NO pathway after heart transplantation (HT). We therefore investigated substances in the NO pathway prior to and after HT in relation to hemodynamic parameters. DESIGN: 12 patients (median age 50.0 yrs, 2 females), heart transplanted between June 2012 and February 2014, evaluated at our hemodynamic lab, at rest, prior to HT, as well as four weeks and six months after HT were included...
April 12, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29436868/effect-of-oxygen-therapy-on-chest-pain-in-patients-with-st-elevation-myocardial-infarction-results-from-the-randomized-soccer-trial
#19
Ardavan Khoshnood, Mahin Akbarzadeh, Marcus Carlsson, David Sparv, Pallonji Bhiladvala, Arash Mokhtari, David Erlinge, Ulf Ekelund
OBJECTIVE: Oxygen (O2 ) have been a cornerstone in the treatment of acute myocardial infarction. Studies have been inconclusive regarding the cardiovascular and analgesic effects of oxygen in these patients. In the SOCCER trial, we compared the effects of oxygen treatment versus room air in patients with ST-elevation myocardial infarction (STEMI). There was no difference in myocardial salvage index or infarct size assessed with cardiac magnetic resonance imaging. In the present subanalysis, we wanted to evaluate the effect of O2 on chest pain in patients with STEMI...
April 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29402147/carotid-im-gsm-is-better-than-imt-for-identifying-patients-with-multiple-arterial-disease
#20
Fisnik Jashari, Pranvera Ibrahimi, Elias Johansson, Christer Grönlund, Per Wester, Michael Y Henein
OBJECTIVE: Atherosclerosis is a systemic inflammatory disease that can affect more than one arterial bed simultaneously. The aim of this study was to determine the relationship between ultrasound markers of atherosclerosis and multiple arterial disease. DESIGN: We have included 87 currently asymptomatic carotid disease patients (mean age 69 ± 6 year, 34% females) in this study. Intima media thickness (IMT) and intima media-grey scale median (IM-GSM) were measured in the common carotid artery (CCA), and correlated with previous and/or current atherosclerotic vascular disease in the coronary, carotid and lower extremities...
April 2018: Scandinavian Cardiovascular Journal: SCJ
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