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Scandinavian Cardiovascular Journal: SCJ

Pia Helene Gustavsen, Dorte Guldbrand Nielsen, Charlotte Paltved, Lars Konge, Leizl Joy Nayahangan
OBJECTIVES: New training methods such as simulation have been introduced in cardiology as in other specialties; however, the development of effective simulation-based training programs is challenging. They are often unstructured and based on convenience or coincidence. The objective of this study was to perform a nationwide general needs assessment to identify and prioritize technical procedures that should be included in a simulation-based curriculum for cardiology residency in Denmark...
January 16, 2019: Scandinavian Cardiovascular Journal: SCJ
Gunn Marit Traaen, Lars Aakerøy, Tove-Elizabeth Hunt, Britt Øverland, Erik Lyseggen, Pål Aukrust, Thor Ueland, Thomas Helle-Valle, Sigurd Steinshamn, Thor Edvardsen, Hasse Khiabani Zaré, Svend Aakhus, Harriet Akre, Ole-Gunnar Anfinsen, Jan Pål Loennechen, Lars Gullestad
RATIONALE: Atrial fibrillation is associated with increased mortality as well as morbidity. There is strong evidence for an association between atrial fibrillation and sleep apnea. It is not known whether treatment of sleep apnea with continuous positive airway pressure (CPAP) will reduce the burden of atrial fibrillation. OBJECTIVE: The Treatment of Sleep Apnea in Patients with Paroxysmal Atrial Fibrillation study will investigate the effects of CPAP in patients with paroxysmal atrial fibrillation and sleep apnea...
January 14, 2019: Scandinavian Cardiovascular Journal: SCJ
Xue Yu, Yi Zhang, Qin Luo, Zhihong Liu, Zhihui Zhao, Qing Zhao, Liu Gao, Qi Jin, Lu Yan
OBJECTIVES: We aimed to investigate the prevalence of iron deficiency (ID) in congenital heart disease associated with pulmonary arterial hypertension (CHD-PAH) and to explore the influence of ID on CHD-PAH patients. What was associated with ID in these patients was also looked into. DESIGN: 153 patients who were newly diagnosed with CHD-PAH were enrolled. Patients were divided into iron-deficient and iron-replete groups according to the following criteria. ID was defined as transferrin saturation <20% in male and transferrin saturation <25% in female...
January 11, 2019: Scandinavian Cardiovascular Journal: SCJ
Klas Winell, Martti Arffman, Arto Pietilä, Veikko Salomaa
OBJECTIVES: Diabetic patients have two-fold excess risk of cardiovascular complications (CVCs). To compare the treatment quality of diabetic patients we compared the incidence of CVCs between the five university hospital districts (UHDs) in Finland. DESIGN: The study population comprised all persons with diabetes in Finland since 1964. They were followed up for the incidence of first acute coronary syndrome (ACS) and first ischemic stroke (IS) using the National Hospital Discharge Register and the National Causes of Death Register data between the years 2000 and 2011...
January 7, 2019: Scandinavian Cardiovascular Journal: SCJ
Aliye Kuyumcu, Mevlüt Serdar Kuyumcu, Mustafa Bilal Özbay, Özcan Özeke
OBJECTIVES: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. Nesfatin-1 regulates blood pressure, heart rate, cardiomyocyte metabolism and permeability . We aimed to evaluate the relationship between carotid artery stenosis (CAS) and nesfatin-1. DESIGN: Three groups were established as patients with no atherosclerotic plaques (n = 60), CAS <60% (n = 60), and CAS ≥60% (n = 60). Then patients with CAS were divided into 2 subgroups as patients with calcific (n = 67) and non-calcific (n = 53) carotid artery stenosis according to plaque morphological features...
January 2, 2019: Scandinavian Cardiovascular Journal: SCJ
Ossama Elsaid, Vinay Gulati, Kristen Tecson, Meir Friedman, Jeffrey Kluger
BACKGROUND: Left ventricular (LV) remodeling and clinical response to cardiac resynchronization therapy (CRT) is inversely related to electrical dyssynchrony, measured as LV lead electrical delay (QLV). Presence of atrial or ventricular arrhythmia is correlated with worsening heart failure and LV remodeling. OBJECTIVE: We sought to assess the association of QLV with arrhythmic events in CRT recipients. METHODS: We identified patients implanted with a CRT device at our center...
December 20, 2018: Scandinavian Cardiovascular Journal: SCJ
E A Kringeland, I Deisenhofer, G Hessling, P Schuster
OBJECTIVES: Catheter ablation is regarded as first-line therapy for symptomatic atrioventricular nodal reentry tachycardia (AVNRT). Ablation induces intended myocardial damage and the extent of myocardial damage may differ between ablation methods. The objective of this MAGMA AVNRT(NCT00875914) substudy was to compare high-sensitive cardiac troponin T (hs-cTnT) levels as a surrogate marker for myocardial damage after manually guided (MAN) AVNRT ablation versus AVNRT ablation using remote magnetic navigation (RMN)...
December 20, 2018: Scandinavian Cardiovascular Journal: SCJ
Guangqi Qin, Liwei Chen, Trygve Sjöberg, Stig Steen
OBJECTIVES: The aim of this study was to investigate how high K+ concentrations can be safely used in cardioplegic solutions without causing severe coronary artery vasocontraction. DESIGN: Twenty-four 50 kg pigs were used. The distal part of the left anterior descending coronary artery was cut into ring segments and transferred into organ baths with Krebs solution bubbled with 95% O2 and 5% CO2 . K+ concentrations between 16 and 127 mM were used to induce vasocontractions at 37, 22, 15, and 8 °C...
November 29, 2018: Scandinavian Cardiovascular Journal: SCJ
Sarah Brøgger Kristiansen, Gry Freja Skovsted, Lukas Adrian Berchtold, Aneta Radziwon-Balicka, Karin Dreisig, Lars Edvinsson, Majid Sheykhzade, Kristian Agmund Haanes
OBJECTIVES: The purinergic system has not been investigated in detail following ischemia/reperfusion (I/R) injury in the heart. In the present study we focus on both release and response to extracellular adenosine triphosphate (ATP). Pannexin (Panx) channels have been shown to be involved in ATP release from myocytes and can activate P2X1 and P2Y2 receptors on the coronary artery. DESIGN: We applied a well characterized I/R model in rats, with 24 hours of reperfusion...
November 27, 2018: Scandinavian Cardiovascular Journal: SCJ
Toralph Ruge, Axel C Carlsson, Jan-Håkan Jansson, Stefan Söderberg, Anders Larsson, Johan Ärnlöv
OBJECTIVE: Increased levels of circulating endostatin have been observed in patients with prevalent ischemic heart disease. However, the association between circulating endostatin, and incident myocardial infarction (MI) is less studied. Our main aim was to study the association between circulating endostatin and incident MI in the community adjusted for established cardiovascular risk factors in men and women. DESIGN: Circulating endostatin was measured in a nested case control study based on three large community-based Swedish cohorts, including 533 MI cases, and 1003 age-, sex- and cohort-matched controls...
November 25, 2018: Scandinavian Cardiovascular Journal: SCJ
Demet Ozkaramanli Gur, Derya Necmiye Özaltun, Savaş Gu Zel, Banu Ayse Sarifakioglu, Aydın Akyu Z, Şeref Alpsoy, Ozge Aycicek, Derya Baykiz
OBJECTIVES: The diagnosis of cardiovascular involvement in ankylosing spondylitis (AS) is usually delayed since conventional echocardiography relies mainly on the morphological alterations. The aim of this study was to evaluate the role of echocardiographic methods such as tissue Doppler and strain imaging of left ventricle (LV) and proximal aorta; and concentrations of biomarkers of cardiac fibrosis such as galectin-3 (Gal-3) and soluble suppression-of-tumorogenicity-2 (sST2) in determining early cardiovascular impairment in AS...
November 21, 2018: Scandinavian Cardiovascular Journal: SCJ
Thomas Hofmarcher, David Cabrales Alin, Cecilia Linde
OBJECTIVES: Guidelines of the European Society of Cardiology (ESC) recommend that ferritin and transferrin saturation should be tested in chronic heart failure (HF) and state that iron treatment with ferric carboxymaltose should be considered in HF patients with iron deficiency to alleviate symptoms and improve exercise tolerance and quality of life. This study evaluates the cost effectiveness of the implementation of this recommendation in four Nordic countries (Denmark, Finland, Norway, and Sweden)...
November 20, 2018: Scandinavian Cardiovascular Journal: SCJ
Yongheng Chen, Shan Tan, Mei Liu, Jianming Li
Objective LncRNA TINCR has been reported to be involved in cardiac hypertrophy, while its involvement in diabetic cardiomyopathy is unknown. Materials and Methods In this study, myocardial biopsy and serum collected from patients with diabetic cardiomyopathy, diabetic patients without cardiopathy and healthy controls, and the expression of TINCR in those tissues was detected by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). ROC curve analysis was performed to evaluate the diagnostic value of TINCR expression for diabetic cardiomyopathy...
November 19, 2018: Scandinavian Cardiovascular Journal: SCJ
Heidi-Mari P Myllykangas, Paula K Mustonen, Jari K Halonen, Leena T Berg
Objectivs There are multiple treatment strategies and flap options to cover defects after deep sternal wound infections and other similar sternal defects. The choice of flap is made according to surgeons' preferences and the size and location of the defect. Our aim is to introduce a new option to cover these kinds of defects with an internal mammary artery perforator flap combined with a pectoralis major muscle flap mostly raised with a muscle-sparing technique. Design We treated 13 patients with a sternal defect after cardiothoracic operations with this technique between 2010-2016...
November 17, 2018: Scandinavian Cardiovascular Journal: SCJ
Matias Hannuksela, Bengt Johansson, Bo Carlberg
BACKGROUND: In families with an inherited form of non-syndromic thoracic aortic disease (TAAD), aortic diameter alone is not a reliable marker for disease occurrence or progression. To identify other parameters of aortic function, we studied aortic stiffness in families with TAAD. We also compared diameter measurements obtained by transthoracic echocardiography (TTE) and magnetic resonance imaging (MRI). METHODS: Seven families, including 116 individuals, with non-syndromic TAAD, were studied...
November 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Per Wändell, Axel C Carlsson, Xinjun Li, Danijela Gasevic, Johan Ärnlöv, Martin J Holzmann, Jan Sundquist, Kristina Sundquist
OBJECTIVE: An increased risk of being diagnosed with coronary heart disease or atrial fibrillation has been shown among different immigrant groups. However, less is known on the risk of being diagnosed with congestive heart failure (CHF). DESIGN: We studied CHF in immigrants including all adults ≥45 years in Sweden (n = 3,274,119) from 1998 to 2012. CHF was defined as at the first event registered in the National Patient Register. Risk of incident CHF in immigrant groups compared to the Swedish-born population was assessed by Cox regression, stratified by sex, adjusting for age, socio-demographic status, and co-morbidities...
November 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Christophe Garweg, Stijn De Buck, Bert Vandenberk, Rik Willems, Joris Ector
AIM: 3D Rotational angiography (3DRA) allows for detailed reconstruction of atrial anatomy and is often used in the left atrium to facilitate pulmonary vein isolation. This study aimed to reappraise the anatomy of the right atrium (RA) using 3DRA, specifically looking at Koch's triangle and the cavotricuspid isthmus (CTI) in procedures for atrio-ventricular reentrant tachycardia (AVNRT) and atrial flutter (AFl) ablation. METHODS AND RESULTS: 3DRA was performed in 97 patients undergoing ablation for AVNRT (n = 51) or AFl (n = 46)...
November 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Catharina Borna, Knut Kollberg, David Larsson, Arash Mokhtari, Ulf Ekelund
OBJECTIVES: Chest pain is a common complaint in the emergency department (ED), and it is a challenge to identify low-risk chest pain patients eligible for early discharge. We aimed to develop a simple objective decision rule to exclude 30-day major adverse cardiac events (MACE) in ED chest pain patients. DESIGN: We analyzed prospectively included patients presenting with chest pain. Low risk patients were identified with the clinical objective rule-out evaluation (CORE)...
November 16, 2018: Scandinavian Cardiovascular Journal: SCJ
Zacharias Mandalenakis, Sandra Tahrodi Lennartsson, Michael Fu, Georg Lappas, Shijun Li, Annika Rosengren, Mikael Dellborg, Erik Thunstrom, Kenneth Caidahl, Per-Olof Hansson
OBJECTIVES: To evaluate the incidence of atrial fibrillation (AF) as well as the value of thumb electrocardiography (ECG) for identification of paroxysmal AF in a Swedish cohort of middle-aged men from the general population. DESIGN: A population based random cohort of 798 men underwent screening at the age of 50 and re-examined at the age of 60 and 71 years. At the last examination, a thumb ECG recording was conducted for 2 weeks twice a day in 479 men from the original cohort...
October 10, 2018: Scandinavian Cardiovascular Journal: SCJ
Jakob Almer, Robert B Jennings, Michael Ringborn, Henrik Engblom
OBJECTIVES: An acute coronary occlusion and its possible subsequent complications is one of the most common causes of death. One such complication is ventricular fibrillation (VF) due to myocardial ischemia. The severity of ischemia is related to the amount of coronary arterial collateral flow. In dog studies collateral flow has also been shown to be associated with QRS prolongation. The aim of this study was to investigate whether ischemic QRS prolongation (IQP) is associated with impending VF in an experimental acute ischemia dog model...
September 5, 2018: Scandinavian Cardiovascular Journal: SCJ
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