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Clinical Oral Investigations

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https://www.readbyqxmd.com/read/28315965/evaluation-of-oral-manifestations-of-patients-with-mucopolysaccharidosis-iv-and-vi-clinical-and-imaging-study
#1
Renata Quirino de Almeida-Barros, Paula Frassinetti Vasconcelos de Medeiros, Marcella Quirino de Almeida Azevedo, Adriana de Oliveira Lira Ortega, Angela Toshie Araki Yamamoto, Sheyla Kátia Lúcio Dornelas, Patrícia Meira Bento
OBJECTIVE: The aim of this study is to assess oral manifestations in patients with mucopolysaccharidosis IV (MPS IVA) and mucopolysaccharidosis VI (MPS VI). MATERIALS AND METHODS: Seventeen patients were assessed, nine with MPS IVA and eight with MPS VI, treated at the Medical Genetics Outpatient Clinic of Hospital Universitário Alcides Carneiro (HUAC) in Campina Grande, Paraíba State, Brazil. Assessments included clinical and intraoral examinations, analysis of occlusal function, and panoramic X-rays...
March 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28315964/biological-predictors-of-radiosensitivity-in-head-and-neck-squamous-cell-carcinoma
#2
Mathias Fiedler, Florian Weber, Matthias G Hautmann, Frank Haubner, Torsten E Reichert, Christoph Klingelhöffer, Stephan Schreml, Johannes K Meier, Arndt Hartmann, Tobias Ettl
OBJECTIVES: The aim of this study is to investigate the influence of prognostic biomarkers on radiosensitivity and survival of advanced head and neck squamous cell carcinomas treated by primary (chemo)radiation. MATERIAL AND METHODS: The clinicopathological data and immunohistochemical staining of p16, c-Met, survivin, PD-1, and PD-L1 of 82 primarily (chemo)irradiated patients with head and neck squamous cell carcinoma were analyzed. Associations with local and locoregional radiation response, overall survival (OS), disease-free (DFS), and disease-specific survival (DSS) were assessed...
March 18, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28303471/effect-of-acidity-of-in-office-bleaching-gels-on-tooth-sensitivity-and-whitening-a-two-center-double-blind-randomized-clinical-trial
#3
A D Loguercio, F Servat, R Stanislawczuk, A Mena-Serrano, M Rezende, M V Prieto, V Cereño, M F Rojas, K Ortega, E Fernandez, A Reis
OBJECTIVES: The study aimed to compare the tooth sensitivity (TS) and bleaching efficacy of two hydrogen peroxide gels with different pHs (acid pH [Pola Office, SDI] and the neutral pH [Pola Office+, SDI]) used for in-office bleaching. MATERIALS AND METHODS: Fifty-four patients from Brazil and Chile, with right superior incisor darker than A2, were selected for this double-blind, split-mouth randomized trial. Teeth were bleached in two sessions, with 1-week interval...
March 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28303470/the-caries-preventive-effect-of-1-year-use-of-low-dose-xylitol-chewing-gum-a-randomized-placebo-controlled-clinical-trial-in-high-caries-risk-adults
#4
Fabio Cocco, Giovanna Carta, Maria Grazia Cagetti, Laura Strohmenger, Peter Lingström, Guglielmo Campus
OBJECTIVES: The caries preventive effect of long-term use (1 year) of low-dosage (2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was evaluated. MATERIALS AND METHODS: In this randomized clinical trial, 179 high-caries-risk adults were assigned to two experimental groups, xylitol and polyols. Caries status, salivary mutans streptococci (MS), and plaque pH were re-evaluated after 2 years from baseline in 66 xylitol and 64 polyol subjects...
March 16, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28303469/association-between-maternal-exposure-to-tobacco-presence-of-tgfa-gene-and-the-occurrence-of-oral-clefts-a-case-control-study
#5
Mohammed Junaid, M B Aswath Narayanan, D Jayanthi, S G Ramesh Kumar, A Leena Selvamary
OBJECTIVE: To determine the association between maternal tobacco use or exposure, presence of variant transforming growth factor alpha (TGFA) gene, and the occurrence of oral clefts. METHODS: The present case control study was carried out for 5 months in three tertiary government hospitals in Chennai city with a sample of 100 children (50 children with non syndromic cleft and 50 control) aged 0-24 months. The details of maternal risk factors during the period of gestation were recorded from case and control parents through a pre-validated questionnaire, following which blood samples from 92 children (46 case and 46 controls) based on consent were obtained and evaluated for TGFA gene polymorphism...
March 16, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28293792/bilateral-sagittal-split-osteotomy-parameters-and-correlations-of-postoperative-pain-management
#6
Gregor F Raschke, Winfried Meissner, Andre Peisker, Gabriel Djedovic, Ulrich Rieger, Arndt Guentsch, Marta Gomez Dammeier, Stefan Schultze-Mosgau
OBJECTIVES: Postoperative pain management is of utmost interest for patients undergoing orthognathic surgery. Currently, there is a lack of information regarding process and outcome parameters of postoperative pain management after bilateral sagittal split osteotomy. MATERIALS AND METHODS: In a prospective clinical study, 31 adults were evaluated on the first postoperative day following bilateral sagittal split osteotomy using the standardized questionnaire of the Germany-wide project Quality Improvement in Postoperative Pain Management (QUIPS)...
March 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28283825/temperature-evolution-of-preheated-irrigant-injected-into-a-root-canal-ex-vivo
#7
Ricardo G Macedo, Bram Verhaagen, Michel Versluis, Luc van der Sluis
OBJECTIVES: The aim of this study is to test the influence of the temperature of the surrounding medium, flow rate, duration of irrigation, and apical patency on the evolution of the temperature of irrigants injected in a root canal. MATERIALS AND METHODS: Thermocouples were inserted into an incisor at different positions to monitor irrigant temperature during and after injection at 21, 45, or 60 °C. The tooth was immersed in a water bath at 21 and 37 °C. RESULTS: Preheated syringes were used for up to 2...
March 10, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28281014/lipid-parameters-in-obese-and-normal-weight-patients-with-or-without-chronic-periodontitis
#8
Eduardo Zaccarias Cury, Vanessa Renata Santos, Suellen da Silva Maciel, Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Rosa Maria Salani Mota, Luciene Cristina Figueiredo, Poliana Mendes Duarte
OBJECTIVE: The aim of this study was to evaluate the serum levels of lipids in patients with normal weight (NW) or obesity with or without chronic periodontitis (ChP). MATERIALS AND METHODS: One hundred and sixty non-smoking patients without history of diabetes and/or cardiovascular events were allocated into one of the following groups: NW patients with periodontal health (NWH; n = 40), NW patients with ChP (NWChP; n = 40), obese patients with periodontal health (ObH; n = 40), and obese patients with ChP (ObChP; n = 40)...
March 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28281013/root-canal-morphology-and-variations-in-mandibular-second-molar-teeth-of-an-indian-population-an-in-vivo-cone-beam-computed-tomography-analysis
#9
Ajinkya Mansing Pawar, Mansing Pawar, Anda Kfir, Shishir Singh, Prashant Salve, Bhagyashree Thakur, Prasanna Neelakantan
OBJECTIVES: This study aims to investigate the root canal morphology of permanent mandibular second molars of an Indian population in vivo using cone-beam computed tomography (CBCT) images. METHODS: CBCT images (n = 983; males = 489, females = 494) of untreated, completely developed permanent mandibular second molar teeth were examined. CBCT scans were acquired as part of diagnosis and treatment planning for treatments unrelated to the present study. The number of roots and root canals were recorded...
March 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28281012/novel-endodontic-sealers-induce-cell-cytotoxicity-and-apoptosis-in-a-dose-dependent-behavior-and-favorable-response-in-mice-subcutaneous-tissue
#10
L A B Silva, L U Azevedo, A Consolaro, F Barnett, Y Xu, R A Battaglino, P S Cañadas, Katharina Morant Holanda de Oliveira, R A B Silva
OBJECTIVES: The objective of the present study is to evaluate the in vitro cytotoxicity and in vivo biocompatibility of two novel endodontic sealers: RealSeal XT1 and Sealapex Xpress on the subcutaneous connective tissue of mice. MATERIALS AND METHODS: The cytotoxicity was assessed by cell viability using the MTT assay (one-way ANOVA), trypan blue test (Mann-Whitney) and cell apoptosis by flow cytometer. For the subcutaneous study, polyethylene tubes filled with the sealers were implanted in 70 BALB/c mice: 6 experimental groups (n = 10/group) and 2 control groups with empty tubes (n = 5/group)...
March 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28281011/odontogenic-differentiation-potential-of-human-dental-pulp-cells-cultured-on-a-calcium-aluminate-enriched-chitosan-collagen-scaffold
#11
Diana Gabriela Soares, Hebert Luís Rosseto, Débora Salles Scheffel, Fernanda Gonçalves Basso, Claudia Huck, Josimeri Hebling, Carlos Alberto de Souza Costa
OBJECTIVE: The study aims to evaluate the odontogenic potential of human dental pulp cells (HDPCs) in contact with an experimental porous chitosan-collagen scaffold (CHC) enriched or not with a mineral phase of calcium-aluminate (CHC-CA). MATERIAL AND METHODS: To assess the chemotactic effect of the materials, we placed HDPCs seeded on transwell membranes in intimate contact with the CHC or CHC-CA surface, and the cell migration was monitored for 48 h. Additionally, cells were seeded onto the material surface, and the viability and proliferation were evaluated at several time points...
March 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28275859/gene-expression-of-mirna-138-and-cyclin-d1-in-oral-lichen-planus
#12
Noha A Ghallab, Rehab Fawzy Kasem, Safa Fathy Abd El-Ghani, Olfat G Shaker
OBJECTIVES: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis. METHODS: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression...
March 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28265772/in-vivo-study-for-tooth-colour-determination-visual-versus-digital
#13
Jan Brandt, Shirley Nelson, Hans-Christoph Lauer, Ulrike von Hehn, Silvia Brandt
OBJECTIVES: Tooth colour determination is an essential component in the preservative and prosthetic workflow during production of tooth-coloured restorations. The aim of the study was to compare the clinical suitability of conventional, visual tooth colour determination and digital methods. MATERIALS AND METHODS: Tooth colour of vital, natural central incisors among a total of 107 subjects was determined visually by a dentist (VD) and dental technician (VDT) using VITA Toothguide 3D-MASTER®, digitally by the spectrophotometer VITA Easyshade Advance 4...
March 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28261746/bone-resorptive-activity-in-symptomatic-and-asymptomatic-apical-lesions-of-endodontic-origin
#14
M Salinas-Muñoz, M Garrido-Flores, M Baeza, P Huamán-Chipana, J García-Sesnich, R Bologna, R Vernal, M Hernández
OBJECTIVES: The aim of this study is to assess the levels and diagnostic accuracy of a set of bone resorption biomarkers, including TRAP-5, RANKL, and OPG in symptomatic and asymptomatic apical lesions and controls. MATERIALS AND METHODS: Apical tissues from symptomatic and asymptomatic apical periodontitis patients and periodontal ligaments from healthy teeth extracted for orthodontic reasons were processed for tissue homogenization and the levels of TRAP-5, RANKL, and OPG were determined by multiplex assay...
March 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28261745/ultrasound-examination-with-color-power-doppler-to-assess-the-early-response-of-apical-periodontitis-to-the-endodontic-treatment
#15
Elisabetta Cotti, Stefano Andrea Esposito, Davide Musu, Girolamo Campisi, Hagay Shemesh
OBJECTIVES: The purpose of this study was to assess the possibility to detect early vascular changes in apical periodontitis (AP) using ultrasound examination with color power Doppler (US-CPD) and to establish a correlation between the early response of AP to treatment and its potential healing. MATERIALS AND METHODS: Twenty-one apical lesions were visualized with US-CPD before endodontic treatment, 1 week after the first access to endodontic system and 4 weeks after root canal obturation...
March 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28255753/integrating-genomic-data-from-high-throughput-studies-with-computational-modeling-reveals-differences-in-the-molecular-basis-of-hyposalivation-between-type-1-and-type-2-diabetes
#16
Nili Tickotsky, Yanay Ofran
OBJECTIVES: Both type 1 and type 2 diabetes are accompanied by a high prevalence of hyposalivation (decreased salivary secretion), resulting in oral tissue damage. However, the molecular basis for the hyposalivation is yet unknown. Identifying genes and proteins that account for diabetes-related hyposalivation will help understanding the basis for this condition and identifying disease biomarkers in saliva. MATERIALS AND METHODS: We integrated genomic data from 110 high-throughput studies with computational modeling, to explore the relationship between diabetes and salivary glands on a genomic scale...
March 3, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28255752/is-there-enough-evidence-to-use-botulinum-toxin-injections-for-bruxism-management-a-systematic-literature-review
#17
REVIEW
Giancarlo De la Torre Canales, Mariana Barbosa Câmara-Souza, Camilla Fraga do Amaral, Renata Cunha Matheus Rodrigues Garcia, Daniele Manfredini
OBJECTIVE: The objective of the study was to conduct a systematic review of the literature assessing the effects of botulinum toxin (BoNT-A) injections in the management of bruxism. MATERIALS AND METHODS: Search for articles involved the PubMed, Scopus, Web of Science, Embase, Cochrane, Scielo and Lilacs databases. Specific terms were used and the search carried out from 1980 to March 2016 by three independent researchers. Randomized controlled studies (RCTs), prospective and before-after studies that applied BoNT-A at the masseter and/or temporalis muscles were included...
March 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28251432/impact-of-caries-and-dental-fluorosis-on-oral-health-related-quality-of-life-a-cross-sectional-study-in-schoolchildren-receiving-water-naturally-fluoridated-at-above-optimal-levels
#18
Álvaro García-Pérez, María Esther Irigoyen-Camacho, S Aída Borges-Yáñez, Marco Antonio Zepeda-Zepeda, Irvin Bolona-Gallardo, Gerardo Maupomé
PURPOSE: The purpose of this study was to evaluate the impact of caries and fluorosis on oral health-related quality of life (OHRQoL) among schoolchildren living in areas with high concentrations of fluoride in water. METHODS: Five hundred and twenty-four schoolchildren (8-12 year olds) residing in rural communities in central Mexico were examined for oral hygiene, caries (International Caries Detection and Assessment System, ICDAS II), and fluorosis (Thylstrup and Fejerskov Index, TFI)...
March 1, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28246897/four-year-outcomes-of-restored-posterior-tooth-surfaces-a-massive-data-analysis
#19
Michael Raedel, Andrea Hartmann, Steffen Bohm, Heinz-Werner Priess, Stefanie Samietz, Ioannis Konstantinidis, Michael H Walter
OBJECTIVES: There is only sparse knowledge concerning the outcomes of treatments with posterior permanent restorations in general practice settings. This study aimed at evaluating outcomes based on a large dataset by using a novel approach on a tooth surface basis. MATERIALS AND METHODS: The study based on routine data from a major German national health insurance company. Respective treatment fee codes allowed for tracking the clinical courses on a tooth surface level...
February 28, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28243757/effect-of-the-addition-of-nano-sized-sodium-hexametaphosphate-to-fluoride-toothpastes-on-tooth-demineralization-an-in-vitro-study
#20
Giovanna Dalpasquale, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Gabriel Pereira Nunes, Luiz Fernando Gorup, Francisco Nunes Souza Neto, Emerson Rodrigues de Camargo, Marcelle Danelon
OBJECTIVE: This study evaluated the effect of toothpastes containing 1100 ppm F associated with nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization in vitro using a pH-cycling model. DESIGN: Bovine enamel blocks (4 mm × 4 mm, n = 72) selected by initial surface hardness (SHi) were randomly allocated into six groups (n = 12), according to the test toothpastes: without fluoride or HMPnano (Placebo), 550 ppm F (550F), 1100 ppm F (1100F), 1100F plus HMPnano at concentrations of 0...
February 28, 2017: Clinical Oral Investigations
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