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International Journal of Tuberculosis and Lung Disease

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https://www.readbyqxmd.com/read/30092883/failure-in-tb-control-why-should-the-rapid-diagnostic-test-bear-the-blame
#1
Sachin Atre
No abstract text is available yet for this article.
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092882/an-opportunity-to-compare-the-effects-of-bcg-moreau-and-bcg-russia-in-brazil
#2
Paulo R Z Antas, Mario Flores-Valdez, Frank Shann
No abstract text is available yet for this article.
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092881/cross-border-tuberculosis-opportunities-challenges-and-change
#3
J Foster, E McBryde, M Taune, D Peniyamina
No abstract text is available yet for this article.
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092880/in-reply
#4
E Furtado da Luz, J U Braga
No abstract text is available yet for this article.
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092879/under-reporting-of-tuberculosis-in-praia-cape-verde-study-reports-doubtful-results
#5
Jorge Noel Barreto, Maria de Lourdes Monteiro, Maria da Luz Lima, Emília Valadas, Thomas Hanscheid
No abstract text is available yet for this article.
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092878/-proteobacteria-community-compositions-correlate-with-bronchiectasis-severity
#6
W-J Guan, J-J Yuan, H-M Li, Y-H Gao, Y Huang, C-L Chen, R-C Chen, N-S Zhong
BACKGROUND: Proteobacteria contributes to airway inflammation and poor clinical outcomes in bronchiectasis. OBJECTIVE: To compare sputum Proteobacteria compositions according to bronchiectasis severity. METHODS: Sputum samples collected from 106 patients with stable bronchiectasis and 17 healthy subjects were split for 16srRNA sequencing and biomarker measurement. Pairwise changes in Proteobacteria compositions among 22 of 106 patients during stability, exacerbations and convalescence were compared...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092877/computer-assisted-chest-radiography-reading-for-tuberculosis-screening-in-people-living-with-diabetes-mellitus
#7
R C Koesoemadinata, K Kranzer, R Livia, N Susilawati, J Annisa, N N M Soetedjo, R Ruslami, R Philipsen, B van Ginneken, R D Soetikno, R van Crevel, B Alisjahbana, P C Hill
BACKGROUND: Diabetes mellitus is a significant risk factor for tuberculosis (TB). We evaluated the performance of computer-aided detection for tuberculosis (CAD4TB) in people living with diabetes mellitus (PLWD) in Indonesia. METHODS: PLWD underwent symptom screening and chest X-ray (CXR); sputum was examined in those with positive symptoms and/or CXR. Digital CXRs were scored using CAD4TB and analysed retrospectively using clinical and microbiological diagnosis as a reference...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092876/cost-of-point-of-care-lateral-flow-urine-lipoarabinomannan-antigen-testing-in-hiv-positive-adults-in-south-africa
#8
R Mukora, M Tlali, S Monkwe, S Charalambous, A S Karat, K L Fielding, A D Grant, A Vassall
INTRODUCTION: The World Health Organization recommends point-of-care (POC) lateral flow urine lipoarabinomannan (LF-LAM) for tuberculosis (TB) diagnosis in selected human immunodeficiency virus (HIV) positive people. South Africa had 438 000 new TB episodes in 2016, 58.9% of which were contributed by HIV-positive people. LF-LAM is being considered for scale-up in South Africa. METHODS: We estimated the costs of using LF-LAM in HIV-positive adults with CD4 counts  150 cells/μl enrolled in the TB Fast Track Trial in South Africa...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092875/evaluation-of-line-probe-assay-for-molecular-analysis-and-drug-susceptibility-of-extra-pulmonary-tuberculosis
#9
S Raghuvanshi, A Kotwal, R Maheshwari, G Sindhwani
SETTING: Most epidemiological studies on Mycobacterium tuberculosis focus on pulmonary tuberculosis (TB), whereas extra-pulmonary TB (EPTB) remains poorly explored. OBJECTIVE: To study the rate of resistant EPTB cases among individuals with suspected EPTB using a commercial line-probe assay (LPA), polymerase chain reaction (PCR) and reverse hybridisation test. We also examined the molecular profile of the EPTB isolates obtained at the Himalayan Institute of Medical Sciences, Dehradun, India...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092874/evaluation-of-leucocytes-from-sputum-samples-of-pulmonary-tuberculosis-patients-using-flow-cytometry
#10
P C Gaspar, R C M Rudolf-Oliveira, L M Wildner, A C R de Moraes, M L Reis, R M da Silva, J Gonçalves, M L Bazzo, M C Santos-Silva
SETTING: Information about the sputum cells of pulmonary tuberculosis (PTB) patients is scarce. The analysis of sputum cells using optical microscopy (OM) is a well-established method, but it has some serious limitations. OBJECTIVE: To establish a new flow cytometry (FC) protocol for the leucocyte evaluation of sputum samples from PTB patients. DESIGN: A new FC protocol using 0.1% dithiothreitol and 0.5% paraformaldehyde was developed to fluidise sputum samples and kill Mycobacterium tuberculosis, respectively, to allow the analysis of sputum samples collected from TB patients...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092873/serum-antiphospholipid-antibody-levels-as-biomarkers-for-diagnosis-of-pulmonary-tuberculosis-patients
#11
I Takenami, C C de Oliveira, J D Petrilli, A Machado, L W Riley, S Arruda
SETTING: Salvador, Bahia, Brazil. OBJECTIVE: To evaluate the immunoglobulin (Ig)M and total IgG antibody response to cardiolipin (CL), phosphatidylcholine (PTC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and sulfatide (SL-I) as biosignatures that can be used to diagnose pulmonary tuberculosis (TB) and its applicability for monitoring the efficacy of anti-tuberculosis treatment. DESIGN: Serum samples from 37 adult pulmonary TB patients and 48 controls (16 healthy household contacts, 19 household contacts with latent tuberculous infection [LTBI] and 13 non-TB patients with lung disease) were screened using enzyme-linked immunosorbent assays (ELISAs) for IgM and total IgG against phospholipids...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092872/discordance-in-xpert-%C3%A2-mtb-rif-assay-results-among-low-bacterial-load-clinical-specimens-in-bangladesh
#12
M Sahrin, A Rahman, M K M Uddin, S N Kabir, S Kabir, E Houpt, S Banu
BACKGROUND: The Xpert® MTB/RIF assay detects Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. RIF-resistant (RIF-R) MTB cases detected using Xpert on sputum specimens at three private-sector TB screening centres in Dhaka, Bangladesh, were subjected to consecutive confirmatory Xpert testing, the results of which were MTB-positive/RIF-susceptible, MTB-positive/RIF-indeterminate or MTB-negative. OBJECTIVE: To assess the possible causes of discordant MTB and RIF-R results...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092871/evaluation-of-xpert-%C3%A2-mtb-rif-assay-as-a-diagnostic-test-for-pulmonary-tuberculosis-in-children-in-myanmar
#13
K Myo, M Zaw, T L Swe, Y Y Kyaw, T Thwin, T T Myo, K O Aye, A A Myint
BACKGROUND: The Xpert® MTB/RIF assay has been recommended for the diagnosis of pulmonary tuberculosis (PTB). However, there are limited data from the South-East Asian region. SETTING: This study was carried out at a tertiary-level children's hospital in Mandalay, Myanmar. OBJECTIVE: To evaluate the performance of Xpert as a diagnostic test for PTB in children. METHODS: A cross-sectional descriptive study of children with suspected PTB...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092870/risk-factors-for-gastric-aspirate-culture-contamination-in-children-evaluated-for-tuberculosis-in-botswana
#14
A Ho-Foster, M W Tenforde, T Arscott-Mills, M Maramba, P Sedigeng, B Mbeha, F Banda, A P Steenhoff
SETTING: Gastric aspirate (GA) sample culture is commonly performed in children evaluated for tuberculosis (TB) who cannot expectorate sputum. Contamination limits culture yield and negatively impacts care. OBJECTIVE: To evaluate the proportion of and factors associated with GA contamination at a central TB reference laboratory in Botswana. DESIGN: This was a 5-year cross-sectional study of untreated children aged 12 years evaluated for TB with the first GA sample registered at the National Tuberculosis Reference Laboratory...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092869/burden-spectrum-and-outcomes-of-children-with-tuberculosis-diagnosed-at-a-district-level-hospital-in-south-africa
#15
K du Preez, L du Plessis, N O'Connell, A C Hesseling
SETTING: The Khayelitsha subdistrict has the highest burden of reported tuberculosis (TB) cases in Cape Town, Western Cape Province, South Africa. OBJECTIVES: To characterise the TB burden, spectrum and treatment outcomes among children managed at a district-level hospital, the Khayelitsha District Hospital. DESIGN: Retrospective medical record review of all children (age <13 years) diagnosed with TB in January-July 2014. A lay health care worker completed daily surveillance and supported linkage to TB care...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092868/high-tuberculosis-transmission-rate-in-children-with-nursery-exposure-to-undetected-pulmonary-tuberculosis
#16
C E Oh, G-Y Kwon, Y-H Kwon, E-J Lee, M-S Park, S-H Kim, S-M Jeon, U-Y Go, S E Park
SETTING: Nursery for newborns in Busan, Republic of Korea. OBJECTIVE: To evaluate tuberculosis (TB) transmission from a health care worker with active pulmonary TB to neonatal contacts. DESIGN: For the first investigation, infants who had been in the nursery 3 months before the index patient was diagnosed with pulmonary TB were enrolled. After a child who had stayed in the nursery 10 months before the diagnosis of the index patient was diagnosed with tuberculous meningitis, a second contact investigation was conducted...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092867/-i-didn-t-know-so-many-people-cared-about-me-support-for-patients-who-interrupt-drug-resistant-tb-treatment
#17
L Snyman, E Venables, L Trivino Duran, E Mohr, V D Azevedo, X Harmans, P Isaakidis
SETTING: Early interventions for patients who interrupt their treatment for drug-resistant tuberculosis (DR-TB) are rarely reported and assessed. A novel, patient-centred intervention for patients at risk of loss to follow-up (LTFU) from DR-TB treatment was implemented in Khayelitsha, South Africa, in September 2013. OBJECTIVE: To explore the experiences and perceptions of patients, key support persons, health care workers (HCWs) and programme managers of a patient-centred model...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092866/resource-utilization-for-multidrug-resistant-tuberculosis-household-contact-investigations-a5300-i2003
#18
S Swindells, A Gupta, S Kim, M D Hughes, J Sanchez, V Mave, R Dawson, N Kumarasamy, K Comins, B Smith, R Rustomjee, L Naini, N S Shah, A Hesseling, G Churchyard
BACKGROUND: Current guidelines recommend evaluation of the household contacts (HHCs) of individuals with multidrug-resistant tuberculosis (MDR-TB); however, implementation of this policy is challenging. OBJECTIVE: To describe the resource utilization and operational challenges encountered when identifying and characterizing adult MDR-TB index cases and their HHCs. DESIGN: Cross-sectional study of adult MDR-TB index cases and HHCs at 16 clinical research sites in eight countries...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092865/factors-affecting-tuberculosis-health-message-recall-2-years-after-active-case-finding-in-blantyre-malawi
#19
E J M Monk, M Kumwenda, M Nliwasa, J Mpunga, E L Corbett
SETTING: Urban slums, Blantyre, Malawi. OBJECTIVE: To explore tuberculosis (TB) community-wide active case finding (cwACF) recall and accompanying messaging 2 years after the intervention. DESIGN: This mixed-methods study used population-weighted random cluster sampling to select three cwACF-receiving and three non-cwACF-receiving neighbourhoods in Blantyre. Qualitative data were collected using 12 focus group discussions (community peer-group members) and five in-depth interviews (TB officers) with script guides based on the concepts of the Health Belief Model (HBM)...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/30092864/performance-of-the-quantiferon-%C3%A2-tb-gold-in-tube-assay-in-tuberculin-skin-test-converters-a-prospective-cohort-study
#20
M E Castellanos, S Kirimunda, L Martinez, T Quach, H Woldu, R Kakaire, A Handel, S Zalwango, N Kiwanuka, C C Whalen
OBJECTIVE: To investigate diagnostic agreement of the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test in adult tuberculin skin test (TST) converters in a high tuberculosis (TB) burden setting. SETTING AND DESIGN: We performed a case-cohort study from 2014 to 2016 in Uganda among residents who were not infected with Mycobacterium tuberculosis. Participants were followed up for 1 year, when they were retested to determine TST conversion. All TST converters and a random sample of participants from baseline were offered QFT-GIT testing...
September 1, 2018: International Journal of Tuberculosis and Lung Disease
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