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International Journal of Tuberculosis and Lung Disease

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https://www.readbyqxmd.com/read/29262982/treatment-outcomes-and-tolerability-of-the-revised-who-anti-tuberculosis-drug-dosages-for-children
#1
M Nansumba, E Kumbakumba, P Orikiriza, M Bastard, J A Mwanga, Y Boum, P de Beaudrap, M Bonnet
<h2>BACKGROUND:</h2>In 2010, the World Health Organization (WHO) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazinamide to 35 mg/kg. We assessed treatment outcomes, safety and adherence among children treated with the new recommended dosages.<h2>METHODS:</h2>Prospective cohort of children started on anti-tuberculosis treatment in Uganda with 12 months of follow-up, including alanine aminotransferase (ALT) monitoring...
December 20, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29145924/pharmacokinetic-interaction-between-bedaquiline-and-clofazimine-in-patients-with-drug-resistant-tuberculosis
#2
G Maartens, M J E Brill, M Pandie, E M Svensson
<h2>BACKGROUND:</h2>Bedaquiline (BDQ) and clofazimine (CFZ) are both recommended for treating drug-resistant tuberculosis (DR-TB). As CFZ is an inhibitor of the cytochrome P450 isoenzyme 3A4 (CYP3A4) in vitro, and BDQ a substrate of CYP3A4, there is a potential for pharmacokinetic (PK) drug-drug interaction that may result in increased BDQ exposure when co-administered with CFZ, which could increase the toxicity of BDQ.<h2>METHODS:</h2>We assessed the effect of co-administered CFZ on BDQ bioavailability, or on clearance of BDQ and its N-monodesmethyl metabolite (M2), in patients with DR-TB using a population PK model developed from data of patients with DR-TB...
November 16, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297435/validation-of-spirometry-prediction-equations-in-western-kenya
#3
D W Paul, D K Lagat, N MacIntyre, J R Egger, D M Murdoch, L G Que, P S Kussin
SETTING: Community of Eldoret, Kenya. OBJECTIVE: To test the performance of three commonly used spirometry prediction equations in a healthy Kenyan population. DESIGN: Cross-sectional assessment of healthy adults in Eldoret. RESULTS: Of the 331 subjects enrolled in the study, 282 subjects aged 18-85 years (45% males, 55% females) produced high-quality spirograms. Lung function predictions were made using the Global Lung Initiative 2012 (GLI 2012) prediction equations for African Americans, the National Health and Nutrition Examination Survey III (NHANES III) prediction equations for African Americans, and the Crapo prediction equation...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297434/combining-case-finding-methods-for-copd-in-primary-care-a-large-two-stage-design-study
#4
J B Soriano, J Molina, M Miravitlles
BACKGROUND: Underdiagnosis of chronic obstructive pulmonary disease (COPD) is common. We aimed to assess the effectiveness of using the Chronic Obstructive Pulmonary Disease-Population Screener (COPD-PS) questionnaire with pre-bronchodilator (BD) peak expiratory flow (PEF) measurements as a case-finding strategy for COPD in primary care. METHODS: This was a two-stage, cross-sectional study comprising a population survey in a primary care population aged 35 years without previous COPD, followed by a validation study using COPD-PS 4 or PEF 2...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297433/interstitial-lung-disease-and-risk-of-mortality-11-year-nationwide-population-based-study
#5
W-I Choi, S H Park, S Dauti, B-J Park, C W Lee
BACKGROUND: Patients with interstitial lung disease (ILD) constitute a substantial disease burden. Although ILD outcomes have been investigated, the risk of death due to ILD has not been studied in the light of confounders and comorbidities. In this nationwide, 11-year longitudinal, population-based study, we aimed to discover if ILD is an independent risk factor for mortality. DESIGN: Data on 1 031 392 (2.2%) randomly selected subjects from 47 279 373 Korean residents were collected from the 2002 Korean National Health Insurance database...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297432/vitamin-d-deficiency-in-patients-with-tuberculous-meningitis-and-its-relationship-with-treatment-outcome
#6
G V Dangeti, S Mailankody, C Neeradi, J Mandal, R Soundravally, N M Joseph, S Kamalanathan, R P Swaminathan, T Kadhiravan
SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β). OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients, its association with treatment outcomes and correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF). DESIGN: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital in southern India...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297431/feasibility-and-yield-of-screening-for-non-communicable-diseases-among-treated-tuberculosis-patients-in-peru
#7
A L Byrne, B J Marais, C D Mitnick, F L Garden, L Lecca, C Contreras, Y Yauri, F Garcia, G B Marks
INTRODUCTION: The increasing prevalence of non-communicable diseases (NCDs) poses a major challenge to low- and middle-income countries. Patients' engagement with health services for anti-tuberculosis treatment provides an opportunity for screening for NCDs and for linkage to care. METHODS: We explored the feasibility and yield of screening for NCDs in patients treated for tuberculosis (TB) in Lima, Peru, as part of a study focused on chronic respiratory sequelae...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297430/tuberculosis-among-south-american-immigrants-in-s%C3%A3-o-paulo-municipality-an-analysis-in-space-and-time
#8
P F P S Pinto, F C Neto, M C S de Almeida Ribeiro
OBJECTIVE: To identify spatial and temporal, and spatial variation in temporal trends in clusters of tuberculosis (TB) among South American migrants residing in São Paulo municipality, SP, Brazil, between 2006 and 2013. DESIGN: An ecological descriptive study was conducted using data obtained from official TB reports and the 2010 Brazilian demographic census. Clusters were identified using scan statistics and SaTScan software; those with P < 0.05 were considered statistically significant...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297429/increased-tuberculosis-risk-among-immigrants-arriving-in-california-with-abnormal-domestic-chest-radiographs
#9
J Wong, P Lowenthal, J Flood, J Watt, P M Barry
SETTING: Tuberculosis (TB) cases in California, USA, occur predominantly among foreign-born persons, many of whom have abnormal chest radiographs (CXRs) on overseas medical examination. These persons are recommended for follow-up TB evaluation upon arrival in the United States. OBJECTIVE: To estimate the increased TB risk associated with abnormal vs. normal domestic CXRs among individuals arriving with abnormal overseas CXRs. DESIGN: Cox regression analyses of 35 633 foreign-born persons aged 15 years who arrived in California during 1999-2012 with abnormal overseas CXRs and were free of imported active TB...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297428/bacterial-co-infection-and-early-mortality-among-pulmonary-tuberculosis-patients-in-manila-the-philippines
#10
T Shimazaki, T Taniguchi, N R D Saludar, L M Gustilo, T Kato, A Furumoto, K Kato, N Saito, W S Go, E S Tria, E P Salva, E M Dimaano, C Parry, K Ariyoshi, J B Villarama, M Suzuki
OBJECTIVE: To investigate the prevalence of bacterial co-infection and its effect on early mortality among hospitalised human immunodeficiency virus (HIV) negative pulmonary tuberculosis (PTB) patients in Manila, the Philippines. DESIGN: A prospective observational study was conducted at a national infectious disease hospital. HIV-negative PTB patients aged 13 years hospitalised from November to December 2011 and from December 2012 to May 2013 were enrolled. Sputum samples were tested for Mycobacterium tuberculosis and six respiratory bacterial pathogens using polymerase chain reaction (PCR)...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297427/estimating-the-impact-of-a-television-campaign-on-tuberculosis-knowledge-and-intention-to-test-for-tb-in-south-korea
#11
B Lee, H J Oh, B S Chon
OBJECTIVE: To examine the effectiveness of a television campaign for preventing tuberculosis (TB) executed in South Korea in 2015. DESIGN: We used a genetic matching method to accurately test the effect of the campaign on changing people's knowledge and behaviour in a nationwide sample of 1000 adults; information was collected using face-to-face interviews. RESULTS: After matching individuals in treatment and controlled conditions using 11 covariates, we found that the campaign significantly improved people's knowledge about TB, and enhanced people's intention to undertake a TB test when they recognised the signs of TB...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297426/risk-factors-for-extensive-drug-resistance-in-multidrug-resistant-tuberculosis-cases-a-case-case-study
#12
L Guglielmetti, N Veziris, A Aubry, F Brossier, C Bernard, W Sougakoff, V Jarlier, J Robert
SETTINGS: Identification of extensively drug-resistant tuberculosis (XDR-TB) may be delayed because of the lack of availability of molecular testing for second-line drugs (SLDs). Early suspicion of XDR-TB is therefore necessary to avoid developing further drug resistance. OBJECTIVE: To identify the characteristics associated with XDR-TB among multidrug-resistant TB (MDR-TB) cases before the availability of second-line drug susceptibility testing (DST) results. METHODS: All MDR-TB cases with available second-line DST results recorded in France from 1998 to 2013 were classified as simple MDR-TB (no resistance to fluoroquinolones [FQs] or second-line injectable drugs [SLIDs]), pre-XDR-TB (resistance to FQs or SLIDs) and XDR-TB cases (resistance to both)...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297425/extensively-drug-resistant-tuberculosis-in-myanmar-burden-and-mutations-causing-second-line-drug-resistance
#13
P W Ei, W W Aung, W W Nyunt, T L Swe, M M Htwe, S M Win, S T Aung, C L Chang, H-Y Lee, J S Lee
SETTING: Two tuberculosis (TB) reference laboratories in Myanmar. OBJECTIVES: To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. DESIGN: This was a cross-sectional, retrospective study. Multidrug-resistant Mycobacterium tuberculosis isolates were collected during 2015-2016. Phenotypic drug susceptibility testing (DST) was performed and drug-resistant mutations identified by sequencing...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297424/household-context-and-psychosocial-impact-of-childhood-multidrug-resistant-tuberculosis-in-kwazulu-natal-south-africa
#14
M Loveday, B Sunkari, I Master, A Daftary, V Mehlomakulu, S Hlangu, B J Marais
SETTING: Referral hospital for drug-resistant tuberculosis (TB) in KwaZulu-Natal, South Africa. OBJECTIVES: We conducted interviews with primary care givers of children admitted with multidrug-resistant TB (MDR-TB) during a 3-month period in 2015 to identify broader household challenges. RESULTS: We interviewed 26 care givers, most of whom were women (85%). Most households had been decimated by TB/MDR-TB and human immunodeficiency virus (HIV) infection, and were dependent upon government grants...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297423/meropenem-clavulanate-for-drug-resistant-tuberculosis-a-follow-up-of-relapse-free-cases
#15
M C Payen, I Muylle, O Vandenberg, V Mathys, M Delforge, S Van den Wijngaert, N Clumeck, S De Wit
BACKGROUND: Extensively drug-resistant tuberculosis (XDR-TB), defined as TB caused by a Mycobacterium strain resistant to at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains a worldwide public health threat. Among repurposed drugs empirically used for XDR-TB cases, carbapenems have been studied in vitro and in animal models, with encouraging results. However, only short-term follow-up data from clinical studies are currently available...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297422/steady-state-pharmacokinetics-of-cycloserine-in-patients-on-terizidone-for-multidrug-resistant-tuberculosis
#16
R Court, L Wiesner, A Stewart, N de Vries, J Harding, G Maartens, T Gumbo, H McIlleron
SETTING: Terizidone/cycloserine (TRD/CS) is included in standard treatment regimens for multidrug-resistant tuberculosis (MDR-TB) in many countries. The steady state pharmacokinetics (PKs) of CS after TRD administration are not known. OBJECTIVES AND DESIGN: We recruited in-patients treated with 250-750 mg oral TRD daily as part of standard treatment regimens for pulmonary MDR-TB in Cape Town, South Africa. Plasma CS assays were performed in samples taken pre-dose and at 2, 4, 6, 8 and 10 h post-dose...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297421/tuberculosis-and-diabetes-in-low-and-moderate-tuberculosis-incidence-countries
#17
P-H Lee, H Fu, M-R Lee, M Magee, H-H Lin
In countries with low and moderate incidence of tuberculosis (TB), the disease tends to concentrate in specific high-risk populations such as people with diabetes mellitus (DM). We review the updated evidence on the association between 1) DM and active TB, and 2) DM and latent tuberculous infection (LTBI), and 3) we summarize the findings on the population-level impact of DM on TB epidemiology, with particular focus on low- and moderate-incidence settings. We conducted an updated review of studies on DM and active TB, and found 11 more cohort studies published after the previous systematic review from 2008...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297420/the-rise-of-interstitial-lung-diseases
#18
Rogelio Pérez-Padilla, Moisés Selman
No abstract text is available yet for this article.
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297419/social-science-is-needed-to-understand-the-impact-of-paediatric-mdr-tb-treatment-on-children-and-their-families
#19
Graeme Hoddinott, Anneke C Hesseling
No abstract text is available yet for this article.
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297418/eliminating-tuberculosis-in-low-burden-countries
#20
Charlotte Jackson, Ted Cohen, Molebogeng X Rangaka, Ibrahim Abubakar
No abstract text is available yet for this article.
January 1, 2018: International Journal of Tuberculosis and Lung Disease
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