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International Journal of Tuberculosis and Lung Disease

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https://www.readbyqxmd.com/read/29991411/in-reply
#1
Lauren A Saag, C Robert Horsburgh
No abstract text is available yet for this article.
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991410/thin-body-habitus-is-a-risk-factor-for-active-pulmonary-tuberculosis-but-not-for-infection
#2
Edward D Chan
No abstract text is available yet for this article.
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991409/multidrug-resistant-tuberculosis-in-ukraine-what-is-hidden-behind-the-numbers
#3
J-P Zellweger
No abstract text is available yet for this article.
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991408/evaluation-of-panels-of-mycobacterium-tuberculosis-antigens-for-serodiagnosis-of-tuberculosis
#4
Z H Yan, L Yi, P J Wei, H Y Jia, J Wang, X J Wang, B Yang, X Gao, Y L Zhao, H T Zhang
OBJECTIVE: To evaluate antibody responses to panels of Mycobacterium tuberculosis antigens for serological diagnosis of active tuberculosis (TB). DESIGN: We cloned, expressed and purified 10 M. tuberculosis recombinant proteins 38KD, MPT32 (M. tuberculosis protein 32), MPT64, EspC (ESX-1 secretion-associated protein), Mtb81, Rv3881, Rv3425, Rv0222, Rv3872 and CFP21 (culture filtrate protein 21), and obtained lipoarabinomannan (LAM) polysaccharide antigen from BEI Resources...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991407/blood-transcriptomic-markers-of-mycobacterium-tuberculosis-load-in-sputum
#5
K M Dupnik, J M Bean, M H Lee, M A Jean Juste, L Skrabanek, V Rivera, C K Vorkas, J W Pape, D W Fitzgerald, M Glickman
BACKGROUND: Peripheral blood transcriptome signatures that distinguish active pulmonary tuberculosis (TB) from control groups have been reported, but correlations of these signatures with sputum mycobacterial load are incompletely defined. METHODS: We assessed the performance of published TB transcriptomic signatures in Haiti, and identified transcriptomic biomarkers of TB bacterial load in sputum as measured by Xpert® MTB/RIF molecular testing. People in Port au Prince, Haiti, with untreated pulmonary TB (n = 51) formed the study cohort: 19 people with low and 32 with high sputum Mycobacterium tuberculosis load...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991406/evaluation-of-omnigene-%C3%A2-%C3%A2-sputum-reagent-for-mycobacterial-culture
#6
J Zallet, I D Olaru, A-K Witt, P Vock, B Kalsdorf, S Andres, D Hillemann, K Kranzer
SETTING: National Mycobacterium Reference Laboratory, Borstel, Germany. OBJECTIVE: To evaluate the effectiveness of OMNIgene®•SPUTUM (OM-S) reagent in comparison with a method using N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH) with regard to mycobacterial recovery and contamination of broth and solid cultures. DESIGN: Sputum samples from patients with tuberculosis and other respiratory diseases underwent decontamination with NALC-NaOH-based (MycoDDR™) or OM-S reagent...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991405/modelling-the-long-acting-administration-of-anti-tuberculosis-agents-using-pbpk-a-proof-of-concept-study
#7
R K R Rajoli, A T Podany, D M Moss, S Swindells, C Flexner, A Owen, M Siccardi
SETTING: Anti-tuberculosis formulations necessitate uninterrupted treatment to cure tuberculosis (TB), but are characterised by suboptimal adherence, which jeopardises therapeutic efficacy. Long-acting injectable (LAI) formulations or implants could address these associated issues. OBJECTIVE: niazid, rifapentine, bedaquiline and delamanid-in adults for treatment for latent tuberculous infection (LTBI). DESIGN: PBPK models were developed and qualified against available clinical data by integrating drug physicochemical properties and in vitro and population pharmacokinetic data into a mechanistic description of drug distribution...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991404/therapeutic-drug-monitoring-of-cycloserine-and-linezolid-during-anti-tuberculosis-treatment-in-beijing-china
#8
H Zhu, S-C Guo, Z-Q Liu, B Wang, L Fu, N-H Chu, Y Lu
SETTING: Plasma concentrations of cycloserine (CS) and linezolid (LZD) in tuberculosis (TB) patients are largely unknown. OBJECTIVE: To measure the plasma concentrations of CS and LZD after drug ingestion in drug-resistant TB patients. DESIGN: Patients who received CS and LZD as part of their treatment between 1 July 2012 and 1 July 2016 were studied retrospectively. CS and LZD plasma levels were determined using high-pressure liquid chromatography-tandem mass spectrometry...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991403/effect-of-lidocaine-on-kanamycin-injection-site-pain-in-patients-with-multidrug-resistant-tuberculosis
#9
R G Court, L Wiesner, M T Chirehwa, A Stewart, N de Vries, J Harding, T Gumbo, H McIlleron, G Maartens
SETTING: Reducing pain from intramuscular injection of kanamycin (KM) could improve the tolerability of multidrug-resistant tuberculosis (MDR-TB) treatment. Lidocaine has been shown to be an effective anaesthetic diluent for some intramuscular injections, but has not been investigated with KM in the treatment of adult patients with MDR-TB. OBJECTIVE AND DESIGN: We performed a randomised single-blinded crossover study to determine if lidocaine reduces KM injection-site pain...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991402/impact-of-adverse-drug-reactions-on-the-incremental-cost-effectiveness-of-bedaquiline-for-drug-resistant-tuberculosis
#10
K Schnippel, C Firnhaber, L Page-Shipp, E Sinanovic
BACKGROUND: Adverse drug reactions (ADRs) are common during standard, long-course treatment for multidrug-resistant and rifampicin-resistant tuberculosis (MDR-/RR-TB). In particular, second-line injectables (SLIs) are associated with permanent hearing loss, acute renal injury and electrolyte imbalance. We adapted an established Markov model for ambulatory treatment to estimate the impact of the toxicity profile on the incremental cost-effectiveness ratio (ICER) for a proposed MDR-/RR-TB regimen replacing the SLI with bedaquiline (BDQ)...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991401/economic-burden-of-multidrug-resistant-tuberculosis-a-multicenter-study-across-vietnamese-regions
#11
V X Nam, N V Nhung, N B Hoa, H T T Thuy, N T M Phuong, N T Anh, L T Ngoc Anh, V Q Trung, T V Ha, A Meeyai, M Thavorncharoensap, U Chaikledkaew
SETTING: Multidrug-resistant tuberculosis (MDR-TB) has become a major worldwide health problem. Various studies have been conducted on the cost of MDR-TB treatment; however, this has remained largely unexplored in Viet Nam. OBJECTIVE: To estimate the total cost of MDR-TB treatment at several health care facilities in Viet Nam. DESIGN: A prospective, prevalence-based study was conducted at three selected centers from March to June 2016 in 204 patients, 102 of whom were treated for 9 months and 102 for 20 months...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991400/can-patients-afford-the-cost-of-treatment-for-multidrug-resistant-tuberculosis-in-ethiopia
#12
D Collins, D Beyene, Y Tedla, H Mesfin, E Diro
SETTING: Ethiopia has a high prevalence of tuberculosis (TB) and is one of the countries with the highest burden of multidrug-resistant TB (MDR-TB). OBJECTIVE: To understand the costs that patients incur in obtaining diagnosis and treatment for MDR-TB. DESIGN: In March 2013, interviews were conducted with 169 MDR-TB patients at three hospitals in Ethiopia to identify the cost to patients and the impact on employment and family income. RESULTS: The average MDR-TB patient incurred a total cost of US$1378, which represented 25 months of a mid-treatment household income of US$54...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991399/impact-of-scaling-up-xpert-%C3%A2-mtb-rif-testing-for-the-detection-of-rifampicin-resistant-tb-cases-in-karachi-pakistan
#13
W M Awan, S M A Zaidi, S S Habib, S Khowaja, A Malik, U Khan, R A Ferrand, J Creswell, A Khan
SETTING: Pakistan ranks fourth among the countries with a high burden of multidrug-resistant tuberculosis (MDR-TB), with only 19.2% of the 15 000 estimated incident cases being notified. Increasing treatment coverage for MDR-TB is a key priority for Pakistan's National Tuberculosis Programme. The World Health Organization recommends the use of the Xpert® MTB/RIF assay as the first-line diagnostic test for individuals with presumed TB. OBJECTIVE: To describe a multifaceted case-finding intervention targeting public and private sector health care facilities that used the Xpert assay as a frontline diagnostic test for individuals with presumptive TB, in Karachi, Pakistan, and its impact on case notifications of MDR-TB...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991398/improving-rifampicin-resistant-tuberculosis-diagnosis-using-xpert-%C3%A2-mtb-rif-modelling-interventions-and-costs
#14
R Dunbar, P Naidoo, N Beyers, I Langley
SETTING: Cape Town, South Africa. OBJECTIVE: To model the diagnosis of rifampicin-resistant tuberculosis (RR-TB) and laboratory costs of smear/culture and Xpert-based algorithms and the effect of varying adherence and human immunodeficiency virus (HIV) testing in the Xpert-based algorithm. METHODS: We used a validated operational model (100 000 population) and published laboratory cost data. We estimated the number and cost of RR-TB cases identified using the smear/culture- and Xpert-based algorithms...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991397/p2x7-receptor-polymorphisms-and-susceptibility-to-tuberculosis-in-a-north-indian-punjabi-population
#15
A Chaudhary, J P Singh, P K Sehajpal, B C Sarin
BACKGROUND: Genetic elements are known to influence susceptibility to tuberculosis (TB). P2X7R is a candidate gene with multiple single-nucleotide polymorphisms (SNPs) that has the potential to influence an individual's ability to kill the intracellular pathogen Mycobacterium tuberculosis. OBJECTIVE: To explore the role of five functional polymorphisms of P2X7R in susceptibility or resistance to TB in a North Indian Punjabi population. DESIGN: A case-control study was conducted among 245 TB patients (145 pulmonary TB [PTB] and 100 extra-pulmonary TB [EPTB]) and 247 healthy controls...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991396/strain-diversity-and-relative-transmission-of-mycobacterium-tuberculosis-in-south-coastal-karnataka-india
#16
K Chawla, A Kumar, V P Shenoy, D S Chauhan, P Sharma
BACKGROUND: There are no published reports on the strain diversity and relative transmission of Mycobacterium tuberculosis isolates circulating in Karnataka State, India. OBJECTIVE: To explore the strain diversity of M. tuberculosis isolates and their relative transmission in south coastal Karnataka using spoligotyping and mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR) typing. DESIGN: A total of 108 clinical isolates of M...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991395/older-age-at-first-tuberculosis-diagnosis-is-associated-with-tuberculosis-recurrence-in-hiv-negative-persons
#17
Y F van der Heijden, F Karim, T Chinappa, G Mufamadi, L Zako, B E Shepherd, F Maruri, M-Y S Moosa, T R Sterling, A S Pym
SETTING: Tuberculosis (TB) clinic in Durban, South Africa. OBJECTIVE: To assess the factors associated with TB recurrence among human immunodeficiency virus (HIV) negative adults and children. DESIGN: We conducted a retrospective longitudinal study from January 2000 to December 2012. We defined recurrence as a TB episode occurring within the study period after treatment completion or cure of a previous episode. We used a multivariable Poisson regression model to assess the factors associated with the number of recurrences among HIV-negative patients...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991394/daily-cough-frequency-in-tuberculosis-and-association-with-household-infection
#18
R D Turner, S S Birring, M Darmalingam, R L Hooper, H Kunst, S Matos, G H Bothamley
SETTING: Although cough in tuberculosis (TB) is presumed to be important for transmission, there is little objective supporting evidence. OBJECTIVE: To describe 24-h cough frequency in a group with TB, and investigate associations with household rates of infection. DESIGN: Patients with a new diagnosis of pulmonary TB underwent 24-h cough frequency measurement at or just before initiation of anti-tuberculosis treatment. A group with latent Mycobacterium tuberculosis infection (LTBI) acted as controls...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991393/tuberculosis-preventive-treatment-preferences-among-care-givers-of-children-in-lesotho-a-pilot-study
#19
Y Hirsch-Moverman, J E Mantell, L Lebelo, C Wynn, A C Hesseling, A A Howard, S Nachman, K Frederix, L B Maama, W M El-Sadr
BACKGROUND: Shorter-duration regimens for preventing drug-susceptible tuberculosis (TB) have been shown to be safe and efficacious in children, and may improve acceptability, adherence, and treatment completion. While these regimens have been used in children in low TB burden countries, they are not yet widely used in high TB burden countries. SETTING: Five health facilities in one district in Lesotho, a high TB burden country. OBJECTIVE: Assess the preventive treatment preferences of care givers of child TB contacts...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29991392/improving-childhood-tuberculosis-detection-and-treatment-through-facility-based-screening-in-rural-pakistan
#20
A A Malik, F Amanullah, A J Codlin, S Siddiqui, M Jaswal, J F Ahmed, S Saleem, A Khurshid, H Hussain
SETTING: Many children with tuberculosis (TB) remain undiagnosed due to the absence of services, lack of child-friendly diagnostics and underappreciation of TB as a common cause of childhood illness. OBJECTIVE: To show the impact of systematic verbal screening and contact tracing with appropriate management services on TB case finding in pediatric populations. DESIGN: Between October 2014 and March 2016, children were verbally screened at the pediatric out-patient departments of four public hospitals in Jamshoro District, Pakistan...
August 1, 2018: International Journal of Tuberculosis and Lung Disease
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