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International Journal of Tuberculosis and Lung Disease

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https://www.readbyqxmd.com/read/28087928/factors-associated-with-non-completion-of-follow-up-33-month-latent-tuberculous-infection-treatment-trial
#1
R N Moro, T R Sterling, J Saukkonen, A Vernon, C R Horsburgh, R E Chaisson, C D Hamilton, M E Villarino, S Goldberg
<h2>SETTING:</h2><p>A post-hoc exploratory analysis of a randomized, open-label clinical trial thatenrolled 8053 participants from the United States, Canada, Brazil, and Spain.</p><h2>OBJECTIVE:</h2><p>To assess factors associated with non-completion of study follow-up (NCF) in a 33-month latent tuberculous infection treatment trial, PREVENT TB.</p><h2>DESIGN:</h2><p>Participants were randomized to receive 3 months of weekly directly observed therapy vs...
January 13, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000589/stephen-lawn-1966-2016
#2
Anthony D Harries, Linda-Gail Bekker
No abstract text is available yet for this article.
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000588/active-tuberculosis-patients-have-high-levels-of-iga-anti-alpha-crystallin-and-isocitrate-lyase-proteins
#3
M Talavera-Paulín, L García-Morales, B P Ruíz-Sánchez, Á D Caamal-Ley, A Hernández-Solis, E Ramírez-Casanova, R Cicero-Sabido, C Espitia, C Helguera-Repetto, J A González-Y-Merchand, R Flores-Mejía, S Estrada-Parra, I Estrada-García, R Chacón-Salinas, I Wong-Baeza, J Serafín-López
SETTING: Mexico City, Mexico. OBJECTIVE: To identify proteins synthetised by Mycobacterium tuberculosis in hypoxic culture, which resemble more closely a granuloma environment than aerobic culture, and to determine if they are recognised by antibodies from patients with active pulmonary tuberculosis (PTB). DESIGN: Soluble extracts from M. tuberculosis H37Rv cultured under aerobic or hypoxic conditions were analysed using two-dimensional polyacrylamide gel electrophoresis, and proteins over-expressed under hypoxia were identified by mass spectrometry...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000587/the-clinical-utility-of-xpert%C3%A2-mtb-rif-testing-in-induced-sputum
#4
M Y Chew, J Ng, H-M Cai, T G Lim, T K Lim
We performed a prospective clinical audit in hospitalised patients with suspected pulmonary tuberculosis (PTB) with the objective of evaluating the accuracy and clinical utility of Xpert® MTB/RIF in induced sputum in an intermediate-burden setting. Of 450 patients audited, 61 (13.6%) were diagnosed with PTB based on positive culture. The sensitivity, specificity and positive and negative predictive values for Xpert in smear-negative cases for induced sputum were respectively 75%, 99.5%, 94.7% and 97.0%. Xpert in induced sputum may facilitate diagnostic yield and expedite treatment in up to a quarter of PTB patients...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000586/evaluation-of-omnigene%C3%A2-%C3%A2-sputum-stabilised-sputum-for-long-term-transport-and-xpert%C3%A2-mtb-rif-testing-in-nepal
#5
B Maharjan, C D Kelly-Cirino, A Weirich, P S Curry, H Hoffman, K Avsar, B Shrestha
SETTING: German Nepal TB Project, National Tuberculosis Reference Laboratory, Kathmandu, Nepal. OBJECTIVE: To evaluate whether transporting samples in OMNIgene®•SPUTUM (OM-S) reagent from a peripheral collection site to a central laboratory in Nepal can improve tuberculosis (TB) detection and increase the sensitivity of Xpert® MTB/RIF testing. DESIGN: One hundred sputum samples were split manually. Each portion was assigned to the OM-S group (OM-S added at collection, airline-couriered without cold chain, no other processing required) or the standard-of-care (SOC) group (samples airline-couriered on ice, sodium hydroxide + N-acetyl-L-cysteine processing required at the laboratory)...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000585/ifn-%C3%AE-promoter-polymorphisms-do-not-affect-quantiferon%C3%A2-tb-gold-in-tube-test-results-in-a-canadian-population
#6
S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, T B Ball
BACKGROUND: Several studies have shown polymorphisms within the interferon-gamma (IFN-γ) promoter influence cytokine expression. The interferon-gamma release assay (IGRA) relies on the ability to produce IFN-γ in response to tuberculosis (TB) specific antigens. This study determined the relationship between the IFN-γ +874 A/T promoter polymorphism and the performance of the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test in an ethnically diverse Canadian population. METHODS: A total of 190 participants were categorised into three groups based on history of and exposure to TB: active TB (n = 55), TB exposed (n = 55) and presumably TB unexposed controls (n = 80)...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000584/utility-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#7
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Guérin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000583/clinical-characteristics-and-outcomes-of-tuberculosis-in-douala-cameroon-a-7-year-retrospective-cohort-study
#8
B H Mbatchou Ngahane, F Dahirou, C Tchieche, A Wandji, C Ngnié, A Nana-Metchedjin, E Nyankiyé, M L Endale Mangamba, C Kuaban
SETTING: Tuberculosis (TB) clinic, Douala Laquintinie Hospital, Douala, Cameroon. OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes. DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes. RESULTS: Of 8902 TB cases included, 5110 (57...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000582/seasonality-of-tuberculosis-in-israel-2001-2011
#9
I Margalit, C Block, Z Mor
BACKGROUND: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons. OBJECTIVE: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables. METHODS: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Climatic variables included average temperature and average ultraviolet radiation...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28000581/tuberculosis-clinical-units-improve-contact-tracing
#10
S Brugueras, À Orcau, J-P Millet, L Espinosa, A de Andrés, P Gorrindo, J A Caylà
INTRODUCTION: The Barcelona Tuberculosis Programme was established in 1987, and in 2007 five tuberculosis (TB) clinical units were created to improve the follow-up of cases and contacts. This included the designation of a nurse for case management. OBJECTIVE: To assess the impact of the TB clinical units on the screening programme for TB contacts. METHODS: Before-after population-based study before (2003-2007) and after (2008-2013) the creation of the clinical units...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931352/reviewer-index
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931351/stephen-lawn-19662016
#12
Anthony D Harries, Linda-Gail Bekker
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931350/in-reply-1
#13
Lorena Mota, Khalid Al-Efraij, Jonathon Campbell, Victoria Cook, Fawziah Marra Lalji, James Johnston
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931349/in-reply-2
#14
M J Maze, J Paynter, W Chiu, R Hu, M Nisbet, C Lewis
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931348/therapeutic-drug-monitoring-of-first-line-anti-tuberculosis-drugs-comprises-more-than-c2h-measurements
#15
Marieke G G Sturkenboom, Mathieu S Bolhuis, Onno W Akkerman, Wiel C M de Lange, Tjip S van der Werf, Jan-Willem C Alffenaar
No abstract text is available yet for this article.
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931347/perception-intention-and-attempts-to-quit-smoking-among-jordanian-adolescents-from-the-irbid-longitudinal-study
#16
R Jaber, Z B Taleb, R Bahelah, P Madhivanan, W Maziak
OBJECTIVE: To describe important tobacco cessation indicators among adolescent smokers from Irbid, Jordan. METHODS: Participants for this study were selected from the Irbid Longitudinal Study of Smoking Behaviour (20082011). A total of 1781 students were enrolled at baseline from 19 of 60 randomly selected schools (participation rate 95%). Only students who reported current smoking at baseline were included in the study (n = 605). RESULTS: Among the study participants, 74...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931346/pyrazinamide-susceptibility-testing-proposed-new-standard-with-the-bactectm-mgittm-960-system
#17
C Piersimoni, A Mustazzolu, A Iacobino, F Giannoni, G Santoro, G Gherardi, A Del Giudice, R Perna, L Fattorini
The susceptibility of 253 Mycobacterium tuberculosis complex isolates to pyrazinamide (PZA) was assessed using the BACTECTM MGITTM 960 (M960) system. Resistant strains underwent paired repeat testing using 1) a critical concentration of 200 g/ml (PZA-200), and 2) a reduced inoculum of 0.25 ml. They were also examined using the BACTEC 460 (B460) reference method and investigated for pncA mutations. On M960, 37 isolates were resistant. In the PZA-200 assay, 20 of these were resistant and 17 susceptible, while 18 were resistant and 19 susceptible with reduced inoculum...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931345/factors-associated-with-sputum-culture-conversion-in-multidrug-resistant-pulmonary-tuberculosis
#18
B Velayutham, D Nair, T Kannan, C Padmapriyadarsini, K S Sachdeva, J Bency, J S Klinton, S Haldar, A Khanna, S Jayasankar, S Swaminathan
INTRODUCTION: Sputum culture conversion in pulmonary multidrug-resistant tuberculosis (MDR-TB) is important to make treatment-related decisions and prevent transmission of disease. OBJECTIVE: To identify factors associated with sputum culture conversion, and to determine time to culture conversion and the impact of culture conversion on successful treatment outcomes in MDR-/rifampicin (RMP) resistant TB. METHOD: Retrospective analysis of data from treatment cards and registers of MDR-/RMP-resistant patients initiated on treatment under India's Revised National TB Control Programme in Delhi, West Bengal and Kerala from January 2009 to December 2011...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931344/the-clinical-utility-of-xpert-mtb-rif-testing-in-induced-sputum
#19
M Y Chew, J Ng, H-M Cai, T G Lim, T K Lim
We performed a prospective clinical audit in hospitalised patients with suspected pulmonary tuberculosis (PTB) with the objective of evaluating the accuracy and clinical utility of Xpert MTB/RIF in induced sputum in an intermediate-burden setting. Of 450 patients audited, 61 (13.6%) were diagnosed with PTB based on positive culture. The sensitivity, specificity and positive and negative predictive values for Xpert in smear-negative cases for induced sputum were respectively 75%, 99.5%, 94.7% and 97.0%. Xpert in induced sputum may facilitate diagnostic yield and expedite treatment in up to a quarter of PTB patients...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931343/evaluation-of-omnigenesputum-stabilised-sputum-for-long-term-transport-and-xpert-mtb-rif-testing-in-nepal
#20
B Maharjan, C D Kelly-Cirino, A Weirich, P S Curry, H Hoffman, K Avsar, B Shrestha
SETTING: German Nepal TB Project, National Tuberculosis Reference Laboratory, Kathmandu, Nepal. OBJECTIVE: To evaluate whether transporting samples in OMNIgeneSPUTUM (OM-S) reagent from a peripheral collection site to a central laboratory in Nepal can improve tuberculosis (TB) detection and increase the sensitivity of Xpert MTB/RIF testing. DESIGN: One hundred sputum samples were split manually. Each portion was assigned to the OM-S group (OM-S added at collection, airline-couriered without cold chain, no other processing required) or the standard-of-care (SOC) group (samples airline-couriered on ice, sodium hydroxide + N-acetyl-L-cysteine processing required at the laboratory)...
December 2016: International Journal of Tuberculosis and Lung Disease
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