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International Journal of Tuberculosis and Lung Disease

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https://www.readbyqxmd.com/read/28351463/tuberculin-skin-test-and-interferon-gamma-release-assay-use-among-privately-insured-persons-in-the-united-states
#1
K Owusu-Edusei, E L Stockbridge, C A Winston, M Kolasa, R Miramontes
<h2>OBJECTIVE:</h2><p>To describe tuberculin skin test (TST) and interferon-gamma release assay (IGRA) (i.e., QuantiFERON(®)-TB [QFT] and T-SPOT(®).<italic>TB</italic> [T-SPOT]) use among privately insured persons in the United States over a 15-year period.</p><h2>METHODS:</h2><p>We used current procedural terminology (CPT) codes for the TST and IGRAs to extract out-patient claims (2000–2014) and determined usage (claims/100 000)...
March 28, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28303781/delays-in-diagnosis-and-treatment-of-pulmonary-tuberculosis-in-afb-smear-negative-patients-with-pneumonia
#2
Z X Zhang, L-H Sng, Y Yong, L M Lin, T W Cheng, N H Seong, F K Yong
<h2>BACKGROUND:</h2><p>Diagnostic and treatment delays increase the severity and transmission of pulmonary tuberculosis (PTB). This study aimed to evaluate TB diagnostic and treatment delays in acid-fast bacilli (AFB) smear-negative patients.</p><h2>METHODS:</h2><p>This was a retrospective observational study. Patients with positive AFB culture of <i>Mycobacterium tuberculosis</i> complex (MTC) were selected from among hospitalised patients with a diagnosis of pneumonia...
March 16, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399978/dr-dhanpat-rai-nagpaul-1920-2017
#3
Lalit Kant
No abstract text is available yet for this article.
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399977/acute-kidney-injury-during-treatment-for-latent-tuberculous-infection-with-rifampin
#4
J M Wortham, M Goggin, C Mora, L Vandehey, L Manangan, K M Powell
Treatment for latent tuberculous infection (LTBI) is a key strategy for the elimination of tuberculosis. Rare adverse reactions associated with LTBI treatment have been reported. We report the only case of acute kidney injury reported to Centers for Disease Control and Prevention surveillance for LTBI treatment-related adverse events. The patient experienced rapid intravascular hemolysis, resulting in heme pigment nephropathy; he was hospitalized and received three hemodialysis treatments, but recovered without sequelae...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399976/copd-care-in-saudi-arabia-physicians-awareness-and-knowledge-of-guidelines-and-barriers-to-implementation
#5
M E Alsubaiei, P A Frith, P A Cafarella, S Quinn, M S Al Moamary, R D McEvoy, T W Effing
OBJECTIVE: To assess Saudi physicians' awareness and knowledge about chronic obstructive pulmonary disease (COPD) guideline recommendations. METHODS: Cross-sectional study including physicians involved in COPD care in five hospitals in the Eastern Province of Saudi Arabia. The level of physicians' knowledge was considered as satisfactory (score > 80%), fair (score 50-80%) or poor (<50% of total score). RESULTS: Among the 44 physicians included in the study, the mean ± standard deviation knowledge score was 29...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399975/survey-of-health-care-worker-knowledge-about-childhood-tuberculosis-in-high-burden-centers-in-botswana
#6
T Arscott-Mills, L Masole, R Ncube, A P Steenhoff
BACKGROUND: Quantifying health care workers' (HCWs') knowledge about tuberculosis (TB) informs educational interventions. We assessed HCWs' knowledge about childhood TB in Botswana. METHODS: Semi-structured interviews were conducted with HCWs at 46 sites around Botswana using a piloted instrument. Transcripts were double-coded using a coding schema. Discrepancies were resolved by consensus and a systematic thematic analysis was performed. RESULTS: The sites (42 clinics and 4 hospitals) were urban (n = 9, 20%), semi-urban (n = 10, 22%) and rural (n = 27, 58%)...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399974/evaluation-of-the-tuberculosis-infection-control-training-center-tajikistan-2014-2015
#7
C Scott, J Mangan, Z Tillova, P A Jensen, S Ahmedov, J Ismoilova, A Trusov
SETTING: Training center on tuberculosis (TB) infection control (IC) for health care workers in the Central Asian Republics region. OBJECTIVE: To assess the effects of TB IC training courses conducted at the Tuberculosis Infection Control Training Center in Machiton, Tajikistan. DESIGN: Participants who participated in training (n = 89) during the first year of operation (April 2014-February 2015) were invited to participate in a post-training interview...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399973/barriers-to-tuberculosis-care-delivery-among-miners-and-their-families-in-south-africa-an-ethnographic-study
#8
L V Adams, D Basu, S W Grande, S R Craig, M T Patridge, N Panth, V Trump Redd, M Phalaste, A Singo, P Osewe, A G Mulley
SETTING: South African miners suffer the highest tuberculosis (TB) rates in the world. Current efforts to stem the epidemic are insufficient. Historical legacies and persistent disease burden demand innovative approaches to reshape health care delivery to better serve this population. OBJECTIVE: To characterize social and behavioral health determinants for successful TB care delivery and treatment from the perspective of miners/ex-miners, health care workers and policy makers/managers...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399972/economic-support-intervention-improves-tuberculosis-treatment-outcomes-in-rural-nigeria
#9
K N Ukwaja, I Alobu, M Gidado, O Onazi, D C Oshi
SETTING: A secondary care hospital in rural Nigeria. OBJECTIVE: To investigate the feasibility of providing financial incentives to tuberculosis (TB) patients under routine conditions, and to determine their impact on TB treatment outcomes in a low-resource setting. DESIGN: A prospective, non-randomised intervention study. RESULTS: A total of 294 TB patients (respectively 173 and 121 in the control and intervention periods of 3 months' duration each) were registered in the study...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399971/drug-resistant-tuberculosis-in-patients-with-minimal-symptoms-favourable-outcomes-in-the-absence-of-treatment
#10
M Loveday, A Ramjee, G Osburn, I Master, G Kabera, J C M Brust, N Padayatchi, R Warren, G Theron
SETTING: Referral hospital for drug-resistant tuberculosis (DR-TB) in KwaZulu-Natal Province, South Africa. OBJECTIVE: To review the clinical outcomes of patients (age  14 years) with a laboratory-confirmed diagnosis of DR-TB who had minimal symptoms and/or did not have chest radiographic evidence of active disease at referral. These patients were not started on treatment, but were enrolled in an observation programme with follow-up at 2, 6 and 12 months. RESULTS: Of 3345 referred patients diagnosed with DR-TB, 192 (6%) were enrolled in the observation programme...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399970/recurrence-of-tuberculosis-in-a-low-incidence-setting-without-directly-observed-treatment-victoria-australia-2002-2014
#11
K D Dale, M Globan, E L Tay, J M Trauer, P G Trevan, J T Denholm
SETTING: Victoria, Australia, is an industrialised setting with low tuberculosis (TB) incidence and universal health care. Individually tailored adherence support for self-administered daily anti-tuberculosis treatment is provided. Directly observed treatment (DOT) is very rarely used. OBJECTIVE: To review the rate of recurrent TB in Victoria between 2002 and 2014. DESIGN: This was a retrospective cohort study. All recurrent episodes of TB were reviewed and 24-locus MIRU-VNTR (mycobacterial interspersed repetitive units-variable number of tandem repeats) molecular typing was used where possible to determine the likelihood of relapse or reinfection...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399969/implementing-isoniazid-preventive-therapy-in-a-tuberculosis-treatment-experienced-cohort-on-art
#12
B Maharaj, T N Gengiah, N Yende-Zuma, S Gengiah, A Naidoo, K Naidoo
SETTING: Urban clinical research site in Durban, South Africa. OBJECTIVE: To describe outcomes associated with the implementation of isoniazid preventive therapy (IPT) in a cohort of tuberculosis (TB) treatment-experienced human immunodeficiency virus (HIV) infected patients on antiretroviral therapy (ART). DESIGN: We conducted a secondary analysis of data collected between October 2009 and October 2013 from patients enrolled in a prospective cohort study conducted in Durban, South Africa...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399968/tuberculosis-resistance-conferring-mutations-with-fitness-cost-among-hiv-positive-individuals-in-uganda
#13
W Ssengooba, D Lukoye, C J Meehan, D P Kateete, M L Joloba, B C de Jong, F G Cobelens, F van Leth
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is considered to be less transmissible due to the fitness cost associated with drug resistance-conferring mutations in essential genes. OBJECTIVE: To test the hypothesis that TB drug resistance-conferring mutations with fitness cost are more frequent among human immunodeficiency virus (HIV) positive than among HIV-negative patients. DESIGN: We analysed all strains from the two TB drug resistance surveys conducted in Uganda between 2008 and 2011...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399967/type-1-polarised-dendritic-cells-are-a-potent-immunogen-against-mycobacterium-tuberculosis
#14
Y Satake, Y Nakamura, M Kono, H Hozumi, T Nagata, K Tsujimura, N Enomoto, T Fujisawa, N Inui, T Fujiyama, Y Tokura, T Matsui, K Yokomura, M Shirai, H Hayakawa, T Suda
OBJECTIVE: Application of immunotherapy using dendritic cells (DCs) is considered an effective treatment strategy against persistent Mycobacterium tuberculosis infection. With the goal of developing improved therapeutic vaccination strategies for patients with tuberculosis (TB), we tested the ability of ex vivo-generated DCs to induce an effective TB antigen-specific type-1 immune response. METHODS: Monocyte-derived DCs from TB patients were induced to mature using a 'standard' cytokine cocktail (interleukin [IL] 1β, tumour necrosis factor alpha [TNF-α], IL-6 and prostaglandin E2) or a type 1-polarised DC (DC1) cocktail (IL-1β, TNF-α, interferon [IFN] α, IFN-γ and polyinosinic:polycytidylic acid), and were loaded with the established TB antigen 6-kDa early secretory antigenic target protein (ESAT-6)...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399966/validated-methods-for-identifying-tuberculosis-patients-in-health-administrative-databases-systematic-review
#15
L A Ronald, D I Ling, J M FitzGerald, K Schwartzman, G Bartlett-Esquilant, J-F Boivin, A Benedetti, D Menzies
BACKGROUND: An increasing number of studies are using health administrative databases for tuberculosis (TB) research. However, there are limitations to using such databases for identifying patients with TB. OBJECTIVE: To summarise validated methods for identifying TB in health administrative databases. METHODS: We conducted a systematic literature search in two databases (Ovid Medline and Embase, January 1980-January 2016). We limited the search to diagnostic accuracy studies assessing algorithms derived from drug prescription, International Classification of Diseases (ICD) diagnostic code and/or laboratory data for identifying patients with TB in health administrative databases...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399965/impact-of-euro-american-sublineages-of-mycobacterium-tuberculosis-on-new-infections-among-named-contacts
#16
J-Y Feng, L G Jarlsberg, J Rose, J A Grinsdale, M Janes, J Higashi, D H Osmond, P Nahid, P C Hopewell, M Kato-Maeda
BACKGROUND: The impact of demographic, clinical, and bacterial factors on new infection by Euro-American lineage Mycobacterium tuberculosis among contacts of patients with tuberculosis (TB) has not been evaluated. OBJECTIVE: To describe the risk factors for new infection by Euro-American M. tuberculosis sublineages in San Francisco, California. DESIGN: We included contacts of patients with TB due to Euro-American M. tuberculosis. Sublineages were determined by large-sequence polymorphisms...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399964/pooling-sputum-samples-to-improve-the-feasibility-of-xpert-%C3%A2-mtb-rif-in-systematic-screening-for-tuberculosis
#17
J Ho, P Jelfs, P T B Nguyen, V Sintchenko, G J Fox, G B Marks
SETTING: Systematic screening for tuberculosis (TB) using Xpert® MTB/RIF. OBJECTIVE: To determine whether pooling sputum samples for Xpert testing may improve the feasibility and cost-effectiveness of Xpert by reducing the number of Xpert tests required. DESIGN: Mycobacterium tuberculosis-spiked sputum samples at low organism concentrations were used to mimic samples that are more likely to be found in the screening, compared to the diagnostic, setting...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399963/diagnostic-accuracy-of-the-xpert-%C3%A2-mtb-rif-cycle-threshold-level-to-predict-smear-positivity-a-meta-analysis
#18
B Lange, P Khan, G Kalmambetova, H A Al-Darraji, D Alland, U Antonenka, T Brown, M E Balcells, R Blakemore, C M Denkinger, K Dheda, H Hoffmann, A Kadyrov, N Lemaitre, M B Miller, V Nikolayevskyy, E N Ntinginya, N Ozkutuk, J J Palacios, E B Popowitch, J M Porcel, J Teo, G Theron, K Kranzer
SETTING: Xpert® MTB/RIF is the most widely used molecular assay for rapid diagnosis of tuberculosis (TB). The number of polymerase chain reaction cycles after which detectable product is generated (cycle threshold value, CT) correlates with the bacillary burden.OBJECTIVE To investigate the association between Xpert CT values and smear status through a systematic review and individual-level data meta-analysis. DESIGN: Studies on the association between CT values and smear status were included in a descriptive systematic review...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399962/time-lag-between-immigration-and-tuberculosis-rates-in-immigrants-in-the-netherlands-a-time-series-analysis
#19
C van Aart, H Boshuizen, A Dekkers, H Korthals Altes
SETTING AND OBJECTIVE: In low-incidence countries, most tuberculosis (TB) cases are foreign-born. We explored the temporal relationship between immigration and TB in first-generation immigrants between 1995 and 2012 to assess whether immigration can be a predictor for TB in immigrants from high-incidence countries. DESIGN: We obtained monthly data on immigrant TB cases and immigration for the three countries of origin most frequently represented among TB cases in the Netherlands: Morocco, Somalia and Turkey...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399961/cross-border-solutions-needed-to-address-tuberculosis-in-migrating-populations
#20
Drew L Posey, Nina Marano, Martin S Cetron
No abstract text is available yet for this article.
May 1, 2017: International Journal of Tuberculosis and Lung Disease
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