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International Journal of Pharmaceutical Compounding

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https://www.readbyqxmd.com/read/29220342/effect-of-penetration-enhancers-on-the-percuaneous-delivery-of-hormone-replacement-actives
#1
John O Trimble, Bob Light
Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220341/auditing-safety-of-compounding-and-reconstituting-of-intravenous-medicines-on-hospital-wards-in-finland
#2
Eeva Suvikas-Peltonen, Joni Palmgren, Verner Häggman, Ercan Celikkayalar, Raija Manninen, Marja Airaksinen
On the hospital wards in Finland, nurses generally reconstitute intravenous medicines, such as antibiotics, analgesics, and antiemetics prescribed by doctors. Medicine reconstitution is prone to many errors. Therefore, it is important to identify incorrect practices in the reconstitution of medicine to improve patient safety in hospitals. The aim of this study was to audit the compounding and reconstituting of intravenous medicines on hospital wards in a secondary-care hospital in Finland by using an assessment tool and microbiological testing for identifying issues posing patient safety risks...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220340/validation-of-the-technological-process-of-the-preparation-milk-by-vidal
#3
L P Savchenko, V A Mishchenko, V A Georgiyants
Validation was performed on the technological process of the compounded preparation "Milk by Vidal" in accordance with the requirements of the regulatory framework of Ukraine. Critical stages of formulation which can affect the quality of the finished preparation were considered during the research. The obtained results indicated that the quality of the finished preparation met the requirements of the State Pharmacopoeia of Ukraine.
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#4
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220338/basics-of-compounding-compounding-irrigation-solutions-for-sterile-and-nonsterile-preparations
#5
Loyd V Allen
Compounding pharmacists are sometimes called upon to prepare irrigation solutions, especially in the hospital or clinical setting. Irrigations are indicated for washing or bathing surgical incisions, wounds, and body tissues, including body cavities. Some irrigation solutions coming in contact with exposed tissue, must meet stringent requirements of sterility and bacterial endotoxins. Compounded irrigation solutions may involve wound(s), the bladder, and also may be for ophthalmic, otic, and nasal application...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220337/basics-of-compounding-hot-melt-extrusion
#6
Seth DePasquale
Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production. The use of small-scale extruders and 3D printers provides compounders a pathway for developing new dosage forms at a minimal cost while initial research is being completed. This article discusses the uses of Hot Melt Extrusion, the equipment used, the current and future applications, and the challenges with the technology...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220336/join-the-partnership-for-personalized-prescriptions-p3-advocacy-effort
#7
Cynthia Blankenship
No abstract text is available yet for this article.
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220335/features-of-pharmaceutical-compounding-in-the-republic-of-tajikistan
#8
D S Alfred-Ugbenbo, A H Valiev, O A Zdoryk, V A Georgiyants
Despite the deep assortment of finished pharmaceutical products and the reduction in the number of compounding and hospital pharmacies in the Republic of Tajikistan, the need for extemporal medicinal products is still preserved and remains relevant. This article discusses the practice of compounding in the Republic of Tajikistan. History, laws, limits, regulatory institutions, protocols for compounding pharmacy set up, challenges, equipment, extemporaneous formulations, quality control, and storage within regulatory framework are discussed...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220334/orodispersible-films-for-compounding-pharmacies
#9
Anderson O Ferreira, Marcos Antônio F Brandão, Francisco José Raposo, Hudson C Polonini, Nádia Rezende Barbosa Raposo
Orodispersible film can be defined as a solid pharmaceutical form intended for the delivery and rapid local or systemic release of active ingredients, consisting of a water-soluble polymer film that hydrates rapidly, adhering and dissolving immediately when placed on the tongue or in the oral cavity (oral, palatal, gingival, lingual, or sublingual), without the need for water administration or mastication. Due to its outstanding importance in cases of emergency, practicality of use by patients in transit, and high adherence, orodispersible film has evolved in popularity and success among consumers...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220333/feline-transdermal-formulation-considerations
#10
Lauren Eichstadt Forsythe
Transdermal delivery of drugs is comparatively new in feline patients. However, transdermal formulations can be a desirable option for treating feline patients that are not willing participants to medication administration. However, achieving drug penetration across the skin is not always easy, and there are a wide variety of variables that can further affect penetration. This, coupled with a lack of studies, make transdermal administration an unknown with regards to efficacy and safety for many drugs. This article focuses on drugs that are administered transdermally with the intent of producing systemic effects...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220332/prescription-issues-with-the-nams-2017-hormone-therapy-position-statement
#11
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216621/stability-of-dexmedetomidine-in-0-9-sodium-chloride-in-two-types-of-intravenous-infusion-bags
#12
Kathleen Marquis, Benjamin Hohlfelder, Paul M Szumita
Dexmedetomidine is a frequently used sedative in the critical care setting. It is commercially available as a 4-mg/mL premixed compound or as 200-mcg/2-mL vials that must be further diluted prior to administration. However, limited data exist regarding the stability of dexmedetomidine admixtures compounded from the 200-mcg/2-mL vials, particularly for durations greater than 48 hours. Therefore, we performed stability testing on compounded dexmedetomidine prepared in two types of intravenous infusion bags for 14 days...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216620/physicochemical-stability-of-an-oral-suspension-of-trimethoprim-20-mg-ml-in-combination-with-sulfadiazine-200-mg-ml-in-pcca-base-suspendit
#13
Richard A Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Trimethoprim is a diaminopyrimidine antibacterial agent that, like sulfonamides, inhibits bacterial folic acid synthesis, but at a different stage in the metabolic pathway. It has a similar spectrum of activity to the sulfonamides and is given by mouth or by injection, either alone or in conjunction with a sulfonamide, such as sulfadiazine. Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of the two drugs produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria, by inhibiting enzymes in the folic acid pathways, which in turn inhibits bacterial thymidine synthesis...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216619/stability-of-dalteparin-1-000-unit-ml-in-0-9-sodium-chloride-for-injection-in-polypropylene-syringes
#14
Kylian Kirkham, Jessica M Munson, Susan V McCluskey, Kevin K Graner
The stability of dalteparin 1,000 units/mL in 0.9% sodium chloride for injection stored in polypropylene syringes under refrigeration was examined. Dalteparin 1,000-units/mL syringes were prepared by adding 9 mL of 0.9% sodium chloride for injection to 1 mL of dalteparin sodium 10,000 unit/mL from commercial single-use syringes. Compounded solutions in 0.5-mL aliquots were transferred to 1-mL polypropylene syringes and sealed with a Luer lock tip cap and stored at refrigerated temperatures (2°C to 8°C) with ambient fluorescent light exposure...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216618/kinetic-analysis-of-drug-release-from-compounded-slow-release-capsules-of-liothyronine-sodium-t3
#15
Hamid Bakhteyar, Clayton Cassone, Hamed Gilzad Kohan, Shabnam N Sani
The purpose of this study was to formulate extemporaneously compounded Liothyronine Sodium (T3) slow-release capsules and to evaluate their in vitro drug release performance. Twenty-one formulations containing T3 (7.5 µg) with various compositions of two different grades of Methocel E4M and K100M premium (30% to 90%), and/or SimpleCap/Lactose (10% to 70%) were examined. Quality assessment of the capsules was conducted by standard quality control criteria of the United States Pharmacopeia (i.e., weight variation, content uniformity) to ensure their compliance...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216617/basics-of-sterile-compounding-particulate-matter
#16
Michael J Akers
This article focuses on the requirements for particulate matter in sterile products. Topics include particles and quality, particulate matter standards (large- and small-volume injectables), development of the small-volume injectable test, electronic (light obscuration) and microscope testing, and special requirements for particulate matter in biopharmaceutical preparations.
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216616/basics-of-compounding-3d-printing-pharmacy-applications-geometric-shape-effects-on-3d-printing
#17
Loyd V Allen
As patient therapy becomes more specialized and individualized, one applicable method of drug delivery is through 3D printing. With 3D printing, pharmacists can provide either immediate or modified drug release of either an individual drug or multiple drugs in a singledosage unit. The release rates can be varied, not only by excipients in the formulation, but also to some extent by the shapes of the finished-drug preparation. Some studies demonstrating these concepts are included in this article, along with their method of compounding using 3D printing...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216615/quality-control-bar-codes-and-bar-code-scanners-for-unit-dose-medications-in-a-healthcare-setting
#18
(no author information available yet)
No abstract text is available yet for this article.
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216614/iacp-legislative-regulatory-update
#19
(no author information available yet)
No abstract text is available yet for this article.
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216613/documentation-records-and-reports
#20
Michael J Akers
This article deals with documentation to include the beginning of documentation, the requirements of Good Manufacturing Practice reports and records, and the steps that can be taken to minimize Good Manufacturing Practice documentation problems. It is important to remember that documentation for 503a compounding involves the Formulation Record, Compounding Record, Standard Operating Procedures, Safety Data Sheets, etc. For 503b outsourcing facilities, compliance with Current Good Manufacturing Practices is required, so this article is applicable to them...
September 2017: International Journal of Pharmaceutical Compounding
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