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International Journal of Pharmaceutical Compounding

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https://www.readbyqxmd.com/read/30021191/antineoplastic-drug-contamination-on-the-outside-of-prepared-infusion-bags
#1
Oscar Breukels, Toon van der Gronde, Kathleen Simons-Sanders, Mirjam Crul
Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021190/comparative-stability-of-vitamin-k1-oral-liquids-prepared-in-sterile-water-for-injection-and-stored-in-amber-glass-bottles-and-amber-plastic-syringes
#2
Jessica Huffman, Stacy Brown, Paul Lewis, Sarah Lawson, Amanda Ogle, Gina Peacock
The purpose of this study was to evaluate the stability of vitamin K1 oral liquids in Sterile Water for Injection when stored in amber glass bottles and amber plastic syringes under refrigerated conditions. Four 100-mL batches of vitamin K1 in Sterile Water for Injection were prepared in amber glass bottles to protect from light. One of the batches was divided into 1-mL aliquots, using amber plastic oral syringes, and capped. The prepared bottles and syringes were stored in a laboratory refrigerator. On each day of sampling, 1-mL aliquots were removed from each bottle and mixed with an equal volume of ethanol...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021189/long-term-physicochemical-stability-of-concentrated-solutions-of-noradrenaline-bitartrate-in-polypropylene-syringes-for-administration-in-the-intensive-care-unit
#3
Benjamin Lardinois, Johan Pector, Charlotte Delcave, Laura Soumoy, Jacques Jamart, B Bihin, Jean-Daniel Hecq, Laurence M Galanti
Intensive care units use drug solutions within higher concentrations to avoid fluid overload. The purpose of this study was to evaluate the physicochemical stability of concentrated solutions of noradrenaline bitartrate in polypropylene syringes during 30 days of storage at 5°C ± 3°C. Five 50-mL syringes containing 0.240 mg/mL of noradrenaline bitartrate in 0.9% sodium chloride were prepared and stored at 5°C ± 3°C during 30 days. Immediately after preparation and periodically during the storage, noradrenaline concentrations were measured by high-performance liquid chromatography...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021188/kinetics-of-tetracaine-solvolysis-in-propylene-glycol
#4
Timothy B McPherson, William L Neumann, Michael Goolsby, William M Kolling
Tetracaine is a potent ester-type local anesthetic. Recent publications describe the use of TC free base in topical anesthetic formulations containing propylene glycol. While solvolysis of tetracaine in propylene glycol solutions has been reported, there are no detailed reports on the kinetics of tetracaine reaction with propylene glycol. The objectives of the study were to characterize the kinetics and temperature dependence of tetracaine solvolysis in PG solutions. In this study, products of tetracaine degradation in propylene glycol solution at 60°C were collected and analyzed by high-performance liquid chromatographymass spectrometry and nuclear magnetic resonance...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021187/stability-of-extemporaneously-prepared-sodium-benzoate-oral-suspension
#5
Julia R Atkins, Melinda E Lull, Andrew S Decker, David J Hutchinson
The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet. To a beaker, 50 grams of Sodium Benzoate Powder USP was dissolved and filtered, the solution was divided equally into two parts, and each aliquot was added into two separate calibrated 100-mL amber vials. In the first vial, cherry syrup was added to make a final volume of 100 mL. In the second vial, Ora-Sweet was added to give a final volume of 100 mL...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021186/basics-of-sterile-compounding-criteria-for-determining-beyond-use-dating
#6
Matt Martin
Compounding pharmacists must separately and collectively evaluate multiple aspects of a compounded sterile preparation when determining their beyond-use date. Considerations include the microbiological risk level, storage temperature, chemical stability, batch size, and whether or not a sterility test will be performed. The United States Pharmacopeia Chapter <797> provides guidance on the maximum beyond-use date allowed solely based on the microbiological risk level associated with the compounding of a sterile preparation...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021185/basics-of-compounding-nonsterile-compounding-self-emulsifying-drug-delivery-systems-and-other-self-emulsifying-lipid-formulations-part-2
#7
Loyd V Allen
Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsules so they can be appropriate for compounding after the formulation has been developed...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021184/quality-control-water-activity-considerations-for-beyond-use-dates
#8
Loyd V Allen
There are minimum levels of water activity that are required for growth of bacteria and molds. Water activity is the ratio of vapor pressure of water in a product to pure water at the same temperature. Pure distilled water has a water activity of 1. Water activity is also a measure of water in a material that is available to react with or attach itself to other material; it is also called "free" water while the unavailable water is called "bound" water. Higher water activity substances tend to support more microorganisms; bacteria usually require water activity values of at least 0...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021183/the-history-symptoms-causes-risk-factors-types-diagnosis-treatments-and-prevention-of-gout-part-1
#9
LaVonn Williams
Gout, a common and complex form of inflammatory arthritis, is characterized by abnormally elevated levels of uric acid in the blood. It is estimated that 52.5 million people in the U.S. have arthritis or one of the rheumatic diseases, according to the Centers for Disease Control and Prevention. There are over 100 rheumatic diseases and conditions. In the U.S., the most common types of arthritis or rheumatic diseases are osteoarthritis, gout, fibromyalgia, and rheumatoid arthritis, in that order according to prevalence...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021182/compounding-from-a-pharmacy-student-s-perspective
#10
Alexandria Gochenauer
The International Academy of Compounding Pharmacists' Foundation held a student essay contest in the Spring of 2018. Two great submissions were chosen to receive an award. This article features one of the chosen essays, which discusses the benefits that compounding pharmacies/pharmacists offer patients and discusses the importance and advantages of owning/operating a compounding pharmacy.
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021181/compounded-low-dose-naltrexone-for-the-treatment-of-guttate-psoriasis-a-case-report
#11
George Muller, Robert Grieshaber, J Floyd Talley, Mike Riepl, Don Fellows
The ancient autoimmune skin condition psoriasis is still ubiquitous worldwide, produces the same, often-intolerable effects noted in its earliest recorded descriptions, and remains without cure. Management options designed to resolve the itchy, scaly, weeping, erythematous, and often widespread lesions of that disorder are now available, but they vary in efficacy, most are associated with the development of severe adverse effects, and many are prohibitively expensive. In this article, we describe the successful use of a compounded formulation of oral low-dose naltrexone to manage guttate psoriasis in a 75-year-old white male patient...
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/30021180/prescription-factors-related-to-drug-waste-and-pharmacy-solutions
#12
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
July 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878894/trace-level-analysis-of-airborne-hormone-particulates
#13
John O Trimble, Shanna Hampton
Trace levels of airborne hormones during the pharmaceutical compounding process are analyzed by air monitoring and surface sampling. This study is discussed in two parts: the first part discusses the analysis of particulates suspended in the air by using video particle counting; the second part discusses the analysis of particulates settled on the surface by using surface wipe sampling. One solution to the problem of airborne hormones is to incorporate the hormones into a vehicle like a semisolid cream with high surface tension such that there are no powders to be used during the pharmaceutical compounding process...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878893/the-use-and-utility-of-low-dose-naltrexone-capsules-for-patients-with-fibromyalgia
#14
Brianna Cote, Bethany Ross, Jeff Fortner, Deepa Rao
Fibromyalgia is a syndrome associated with chronic, widespread musculoskeletal pain, fatigue, depression, and cognitive dysfunction. With few U.S. Food and Drug Administration-approved treatment options, there is evidence that low-dose naltrexone, an opioid antagonist approved for opioid and alcohol dependence at high doses, may have efficacy in the treatment of fibromyalgia and chronic pain. At the doses required for fibromyalgia treatment, naltrexone needs to be compounded, and no data currently exists regarding the long-term stability of low-dose naltrexone capsules...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878892/comparison-of-rheological-and-sedimentation-behavior-of-commercially-available-suspending-vehicles-for-oral-pharmaceutical-preparations
#15
J Carolina Visser, Inge E J Ten Seldam, Isabella J van der Linden, Wouter L J Hinrichs, Reinier F H Veenendaal, Eli C F Dijkers, Herman J Woerdenbag
A pharmaceutical suspension is a semi-liquid dosage form suitable for patients being unable to swallow solid medicines such as tablets and capsules. A vehicle used for the preparation of pharmaceutical oral suspensions preferably shows pseudo-plastic behavior. In a product that gets thinner with agitation and thicker upon standing, slow settlement of the suspended active pharmaceutical ingredient is combined with good pourability and rehomogenization. This gives the best guarantee of uniformity of dose for oral suspensions...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878891/investigation-of-the-physical-chemical-and-microbiological-stability-of-oral-solutions-compounded-with-herbals
#16
Kateryna O Khokhlova, Oleksandr A Zdoryk
The physical, chemical, and microbiological stability of a compounded oral solution with the active ingredients herbal tinctures of valerian and motherwort with sedative action for pediatric treatment was studied. Evaluations for physical, chemical, and microbiological stability were performed initially and throughout the storage period. Physical stability of the oral solution was assessed by coloration, clarity, and pH of the solution. The physical appearance of the oral solution did not change throughout the study period...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878890/basics-of-compounding-nonsterile-compounding-self-emulsifying-drug-delivery-systems-and-other-self-emulsifying-lipid-formulations-part-1
#17
Loyd V Allen
Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsules so they can be appropriate for compounding after the formulation has been developed...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878889/quality-control-sterile-compounding-analytical-methods-density-determinations-and-quality-control-in-nonsterile-and-sterile-compounding
#18
Loyd V Allen
One is generally introduced to density in the pharmacy calculations class with exercises in converting weights to liquid measurements, etc. However, density has far more applications than that. Density calculations can be utilized in actual compounding for weights and measures, and it is an easy-to-use method for quality control. Density/specific gravity is used in both nonsterile and sterile compounding, as in using automated compounders for parenteral nutrition solutions. Equipment available is both manual and automated, depending upon the preferences of the user and is reasonably priced...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878888/your-presence-is-needed-at-compounders-on-capitol-hill
#19
Cynthia Blankenship
No abstract text is available yet for this article.
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878887/case-report-of-a-human-papillomavirus-infection-treated-with-green-tea-extract-and-curcumin-vaginal-compounded-medications
#20
Kelechi E Agbi, Sara Hover, Maria Carvalho
The human papillomaviruses are the most common sexually transmitted infections in the U.S., and the majority of these infections are cleared by the body's natural immune system without causing any harm. The high-risk human papillomavirus types, however, cause approximately 5 percent of all cancers worldwide. A prophylactic vaccine was recently introduced, but there is still no commercially available treatment that targets active infections. This case study discusses a 48-year-old female who was diagnosed as human papillomavirus positive (+) following a routine gynecological examination...
May 2018: International Journal of Pharmaceutical Compounding
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