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International Journal of Pharmaceutical Compounding

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https://www.readbyqxmd.com/read/29878894/trace-level-analysis-of-airborne-hormone-particulates
#1
John O Trimble, Shanna Hampton
Trace levels of airborne hormones during the pharmaceutical compounding process are analyzed by air monitoring and surface sampling. This study is discussed in two parts: the first part discusses the analysis of particulates suspended in the air by using video particle counting; the second part discusses the analysis of particulates settled on the surface by using surface wipe sampling. One solution to the problem of airborne hormones is to incorporate the hormones into a vehicle like a semisolid cream with high surface tension such that there are no powders to be used during the pharmaceutical compounding process...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878893/the-use-and-utility-of-low-dose-naltrexone-capsules-for-patients-with-fibromyalgia
#2
Brianna Cote, Bethany Ross, Jeff Fortner, Deepa Rao
Fibromyalgia is a syndrome associated with chronic, widespread musculoskeletal pain, fatigue, depression, and cognitive dysfunction. With few U.S. Food and Drug Administration-approved treatment options, there is evidence that low-dose naltrexone, an opioid antagonist approved for opioid and alcohol dependence at high doses, may have efficacy in the treatment of fibromyalgia and chronic pain. At the doses required for fibromyalgia treatment, naltrexone needs to be compounded, and no data currently exists regarding the long-term stability of low-dose naltrexone capsules...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878892/comparison-of-rheological-and-sedimentation-behavior-of-commercially-available-suspending-vehicles-for-oral-pharmaceutical-preparations
#3
J Carolina Visser, Inge E J Ten Seldam, Isabella J van der Linden, Wouter L J Hinrichs, Reinier F H Veenendaal, Eli C F Dijkers, Herman J Woerdenbag
A pharmaceutical suspension is a semi-liquid dosage form suitable for patients being unable to swallow solid medicines such as tablets and capsules. A vehicle used for the preparation of pharmaceutical oral suspensions preferably shows pseudo-plastic behavior. In a product that gets thinner with agitation and thicker upon standing, slow settlement of the suspended active pharmaceutical ingredient is combined with good pourability and rehomogenization. This gives the best guarantee of uniformity of dose for oral suspensions...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878891/investigation-of-the-physical-chemical-and-microbiological-stability-of-oral-solutions-compounded-with-herbals
#4
Kateryna O Khokhlova, Oleksandr A Zdoryk
The physical, chemical, and microbiological stability of a compounded oral solution with the active ingredients herbal tinctures of valerian and motherwort with sedative action for pediatric treatment was studied. Evaluations for physical, chemical, and microbiological stability were performed initially and throughout the storage period. Physical stability of the oral solution was assessed by coloration, clarity, and pH of the solution. The physical appearance of the oral solution did not change throughout the study period...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878890/basics-of-compounding-nonsterile-compounding-self-emulsifying-drug-delivery-systems-and-other-self-emulsifying-lipid-formulations-part-1
#5
Loyd V Allen
Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsules so they can be appropriate for compounding after the formulation has been developed...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878889/quality-control-sterile-compounding-analytical-methods-density-determinations-and-quality-control-in-nonsterile-and-sterile-compounding
#6
Loyd V Allen
One is generally introduced to density in the pharmacy calculations class with exercises in converting weights to liquid measurements, etc. However, density has far more applications than that. Density calculations can be utilized in actual compounding for weights and measures, and it is an easy-to-use method for quality control. Density/specific gravity is used in both nonsterile and sterile compounding, as in using automated compounders for parenteral nutrition solutions. Equipment available is both manual and automated, depending upon the preferences of the user and is reasonably priced...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878888/your-presence-is-needed-at-compounders-on-capitol-hill
#7
Cynthia Blankenship
No abstract text is available yet for this article.
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878887/case-report-of-a-human-papillomavirus-infection-treated-with-green-tea-extract-and-curcumin-vaginal-compounded-medications
#8
Kelechi E Agbi, Sara Hover, Maria Carvalho
The human papillomaviruses are the most common sexually transmitted infections in the U.S., and the majority of these infections are cleared by the body's natural immune system without causing any harm. The high-risk human papillomavirus types, however, cause approximately 5 percent of all cancers worldwide. A prophylactic vaccine was recently introduced, but there is still no commercially available treatment that targets active infections. This case study discusses a 48-year-old female who was diagnosed as human papillomavirus positive (+) following a routine gynecological examination...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878886/establishing-a-rationale-for-compounding-hormone-replacement-therapy
#9
Bruce Biundo
Why compound bioidentical hormones? Are there no similar commercial products? What is unique about the options compounding pharmacists offer compared with what is out in the marketplace? These are questions that physicians and other practitioners are asking, and it is very important that we have intelligent, well-thought answers when we respond. Times have changed, and the challenges we face today in marketing our compounded therapies are not the same as those of twenty years ago. Premarin is no longer at the top of the heap, and there are topical, commercial products that contain bioidentical estradiol, and capsules that contain the same progesterone that we use...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878885/pitch-ointment-applications-in-scar-and-wound-management
#10
Lawson Kloesel, Maria Carvalho, Fabiana Banov
There is a high incidence of household knife-related injuries requiring emergency department treatment in the U.S. The Pitch Ointment, a named formula developed by a compounding pharmacist, was used separately by two patients who suffered a knife injury in a finger and a foot. This formula combines Pinene (L-Alpha) 0.5% and Canada Balsam 5% in PracaSil-Plus, special ingredients with applications in scar and wound healing. The patients' level of satisfaction with the Pitch Ointment was very high since all 4 treatment satisfaction domains by the Treatment Satisfaction Questionnaire for Medication (effectiveness, side effects, convenience, global satisfaction) were rated over 85...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29878884/prescription-influence-and-sphere-of-influence
#11
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877864/topical-ketamine-in-the-treatment-of-complex-regional-pain-syndrome
#12
Melissa J Durham, Hovik S Mekhjian, Jeffery A Goad, Mimi Lou, Michelle Ding, Steven H Richeimer
The purpose of this study was to evaluate the effectiveness and adverse effects of topical ketamine in the treatment of complex regional pain syndrome. Retrospective charts were reviewed of patients 18 years or older diagnosed with complex regional pain syndrome and treated with topical ketamine during the study period of May 2006 to April 2013 in an academic medical center specialty pain clinic. Exclusion criteria consisted of subjects who 1) were treated with topical ketamine for pain syndromes other than complex regional pain syndrome, 2) initiated other pain therapies concurrently with topical ketamine, 3) had less than two documented visits, 4) began use of topical ketamine prior to the start of the study period, 5) were under 18 years of age...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877863/the-influence-of-tablet-formulation-drug-concentration-and-ph-modification-on-the-stability-of-extemporaneously-compounded-levothyroxine-suspensions
#13
Darren Svirskis, Shao-Wei Lin, Helen Brown, Annie Sangaroomthong, Daniel Shin, Ziqi Wang, Hongtao Xu, Rebecca Dean, Preetika Vareed, Maree Jensen, Zimei Wu
Three brands of levothyroxine tablets are currently available in New Zealand (Eltroxin, Mercury Pharma, Synthroid) for extemporaneous compounding into suspensions. This study aims to determine whether tablet brand (i.e., formulation), concentration, storage conditions, as well as pH, impact the stability of compounded levothyroxine suspensions. Using the three available brands of levothyroxine tablets, suspensions were compounded at concentrations of 15 µg/mL and 25 µg/mL and stored at 4°C and 22°C. Samples were withdrawn weekly for 4 weeks, and chemical stability was evaluated using high-performance liquid chromatographic analysis...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877862/evaluation-and-comparison-of-wound-healing-properties-of-an-ointment-alpawash-containing-brazilian-micronized-propolis-and-peucedanum-ostruthium-leaf-extract-in-skin-ulcer-in-rats
#14
Marcel Nani, Andréia Leone, Vinícius Pedro Bom, Andrei Felipe Buszinski, Rebeca Oliveira de Souza, Vanessa Alves Pinheiro, Panagiota Danapoulos, Rosita Swikidisa, Franciane Marquele-Oliveira, Marco Andrey Cipriani Frade, Andresa Aparecida Berretta, Rodrigo José Lupatini Nogueira
Several previous studies have demonstrated improved wound healing associated with natural-based formulations. Therefore, the purpose of this study was to assess the efficacy of a topical formulation containing both a Brazilian micronized propolis extract and a Peucedanum ostruthium leaf extract for the treatment of wounds created by surgical punch in rats. The study was conducted for 14 days and animals were treated as follows: gauze group (G), polyethylene glycol base ointment (Control), AlpaWash (an ointment containing a Brazilian micronized propolis extract and Peucedanum ostruthium leaf extract [Treatment]), and polysporin (one of the most commonly used topical antibiotic ointments, based on bacitracin zinc and polymyxin B sulfate [Reference Standard])...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877861/basics-of-compounding-compounding-microemulsions
#15
Loyd V Allen
Microemulsions offer an innovative approach applicable to pharmaceutical compounding for increasing solubility, permeability, and bioavailability of some drug substances. They can also enhance stability, both chemical and physical, and be prepared as either oil in water or water in oil systems. Microemulsions are thermodynamically stable, optically transparent, isotropic mixtures of oil, water surfactant, and a cosurfactant. The type of emulsion formed depends upon the properties of the oil and surfactants...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877860/quality-control-lessons-learned-from-a-trimix-stability-study-in-a-503a-compounding-pharmacy
#16
Rick Rhoads
Changes in California regulations regarding beyond-use dates of sterile preparations have prompted many compounders to consider stability studies for their formulas. Traditionally, 503A compounders have relied on published data and professional experience to determine stability. However, due to these new regulations, stability studies are now required for California resident and nonresident licensees to extend the beyond-use date of sterile preparations. Conducting studies for the first time can be costly and difficult for compounding pharmacists...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877859/iacp-legislative-regulatory-update-the-international-academy-of-compounding-pharmacists-testifies-at-u-s-house-of-representatives-energy-commerce-health-subcommittee-pharmacy-compounding-hearing
#17
Cynthia Blankenship
No abstract text is available yet for this article.
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877858/personalized-medicine-and-customized-drug-delivery-systems-the-new-trend-of-drug-delivery-and-disease-management
#18
Abhishek Soni, Kuppusamy Gowthamarajan, Arun Radhakrishnan
Over the past few decades, the concept of personalized medicine has proved to play an important role in the healthcare sector. Personalized medicine modifies the current dosage forms according to the needs of the patient. Based on this improved concept, we are now able to bring out best treatment options for a particular individual leading to better therapeutic outcomes and decreased adverse effects. It also has the potential to identify the disease at an earlier stage. It links the diseased condition of a person to the basic genetic and molecular profile causing better understanding of the condition of the patient and to pick out better treatment options...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877857/pharmacogenomics-precision-pharmacy-in-503a-compounding
#19
Joseph Drummond, Daron Bennet, Loyd V Allen
The first recorded mention of a pharmacogenomic response may be that of Pythagoras in 510 BC, when he noted that hemolytic anemia developed in some but not all people who ingested fava beans. The application of such accounts to pharmacotherapy was inevitable, and customized medications have been compounded since antiquity to treat the needs of individual patients. Today, advances in pharmacogenomic testing yield results that enable more effective targeted therapies sooner in the course of treatment, prevent drug-related adverse effects, save cost, and ensure a better therapeutic outcome...
March 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877856/prescription-drug-quality-and-security-act-implementation-subcommittee-hearing
#20
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
March 2018: International Journal of Pharmaceutical Compounding
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