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International Journal of Pharmaceutical Compounding

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https://www.readbyqxmd.com/read/29385389/compatibility-and-stability-of-varubi-rolapitant-injectable-emulsion-admixed-with-intravenous-granisetron-hydrochloride
#1
George Wu, Dan Powers, Stanley Yeung, Frank Chen, Kelly Neelon
Prophylaxis or therapy with a combination of a neurokinin 1 (NK-1) receptor antagonist (RA), a 5-hydroxytryptamine- 3 (5-HT3) RA, and dexamethasone is recommended by international antiemesis guidelines for the prevention of chemotherapy-induced nausea and vomiting for patients receiving highly emetogenic chemotherapy and for select patients receiving moderately emetogenic chemotherapy. VARUBI (rolapitant) is a substance P/NK-1 RA that was recently approved by the U.S. Food and Drug Administration as an injectable emulsion in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385388/compatibility-and-stability-of-varubi-rolapitant-injectable-emulsion-admixed-with-intravenous-palonosetron-hydrochloride-injection-and-dexamethasone-sodium-phosphate-injection
#2
George Wu, Dan Powers, Stanley Yeung, Frank Chen
Prophylaxis or therapy with a combination of a neurokinin 1 (NK-1) receptor antagonist (RA), a 5-hydroxytryptamine-3 (5-HT3) RA, and dexamethasone is recommended by international antiemesis guidelines for the prevention of chemotherapy-induced nausea and vomiting for patients receiving highly emetogenic chemotherapy and for selected patients receiving moderately emetogenic chemotherapy. VARUBI (rolapitant) is a substance P/NK-1 RA that was recently approved by the U.S. Food and Drug Administration as an injectable emulsion in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385387/stability-of-an-alcohol-free-dye-free-hydrocortisone-2-mg-ml-compounded-oral-suspension
#3
Arushi Manchanda, Melissa Laracy, Taslim Savji, Robin H Bogner
The stability of hydrocortisone in a commercially available dye-free oral vehicle was monitored to establish a beyond-use date for hydrocortisone oral suspension 2 mg/mL. Hydrocortisone oral suspension (2 mg/mL) was prepared from 10-mg tablets in a dye-free oral vehicle (Oral Mix, Medisca) and stored at 4°C and 25°C for 90 days in amber, plastic prescription bottles and oral syringes. The suspendability and dose repeatability of the oral suspension were evaluated. The solubility of hydrocortisone in the dye-free vehicle was determined...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385386/effects-of-compounded-stanford-modified-oral-rinse-mucolox-on-the-survival-and-migration-of-oral-keratinocytes-and-fibroblasts-implications-for-wound-healing
#4
Guiyun Song, Daniel Banov, August S Bassani
Several oral rinses are commercially available to alleviate the symptoms of oral mucositis. Prolonged retention of active pharmaceutical ingredients in the oral cavity is a major problem. In this study, we modified the Stanford oral rinse by including a proprietary mucoadhesive polymer called MucoLox, which we hypothesized would improve active pharmaceutical ingredient mucoadhesion. Characterization of this newly compounded oral rinse showed absence of cytotoxicity in human oral keratinocyte and fibroblast cell lines...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385385/sterile-basics-of-compounding-relationship-between-syringe-size-and-dosing-accuracy
#5
Tracy M Kosinski, Michael C Brown, Pedro J Zavala
The purpose of this study was to investigate the accuracy and reproducibility of a 2-mL volume injection using a 3-mL and 10-mL syringe with pharmacy student compounders. An exercise was designed to assess each student's accuracy in compounding a sterile preparation with the correct 4-mg strength using a 3-mL and 10-mL syringe. The average ondansetron dose when compounded with the 3-mL syringe was 4.03 mg (standard deviation ± 0.45 mg), which was not statistically significantly different than the intended 4-mg desired dose (P=0...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385384/basics-of-compounding-providing-pharmacy-services-to-bariatric-surgery-patients
#6
Linda F McElhiney
With the rise in obesity, more individuals are choosing bariatric surgery as a means to successfully lose weight and resolve co-morbidities. These patients need lifelong support from friends, family, and healthcare providers. Pharmacists need to be knowledgeable of the unique needs of these patients in order to provide information and recommendations on drug therapies and supplements. When a patient is wheeled out of the operating room following bariatric surgery, his or her life instantly changes. Like an infant, the patient has to slowly learn how to eat and drink again...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385383/the-international-academy-of-compounding-pharmacists-government-affairs-lookback-on-2017-accomplishments-and-look-ahead-at-2018-initiatives
#7
Cynthia Blankenship
No abstract text is available yet for this article.
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385382/pain-systematic-review-of-pharmacy-compounding-of-pain-medication
#8
Mohammad S Shawaqfeh, Catherine Harrington
There are limited resources available for pharmacists and doctors to reference proper compounded formulas for pain medications. The systematic review discussed within this article provides the foundation for a searchable database, allowing users to find various compounded formulations. It also provides data about the safety and efficacy of the preparations. Compounding information about several drug classes was reviewed. Those drug classes included, but were not limited to, opioids, non-steroidal anti-inflammatory drugs, central nervous system agents, and anesthetics, with evidence that of the various drugs that could be compounded for pain, anesthetics, non-steroidal anti-inflammatory drugs, and opioids ranked highest within the articles researched...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385381/certification-accreditation-and-credentialing-for-503a-compounding-pharmacies
#9
Jon Pritchett, Gary McCrory, Cheri Kraemer, Brenda Jensen, Loyd V Allen
The terms certification, accreditation, and credentialing are often used interchangeably when they apply to compounding-pharmacy qualifications, but they are not synonymous. The reasons for obtaining each, the requirements for each, and the benefits of each differ. Achieving such distinctions can negatively or positively affect the status of a pharmacy among peers and prescribers as well as a pharmacy's relationships with third-party payors. Changes in the third-party payor industry evolve constantly and, we suggest, will continue to do so...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385380/prescription-2017-some-good-things-happened-and-some-others
#10
EDITORIAL
Loyd V Allen
No abstract text is available yet for this article.
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220342/effect-of-penetration-enhancers-on-the-percuaneous-delivery-of-hormone-replacement-actives
#11
John O Trimble, Bob Light
Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220341/auditing-safety-of-compounding-and-reconstituting-of-intravenous-medicines-on-hospital-wards-in-finland
#12
Eeva Suvikas-Peltonen, Joni Palmgren, Verner Häggman, Ercan Celikkayalar, Raija Manninen, Marja Airaksinen
On the hospital wards in Finland, nurses generally reconstitute intravenous medicines, such as antibiotics, analgesics, and antiemetics prescribed by doctors. Medicine reconstitution is prone to many errors. Therefore, it is important to identify incorrect practices in the reconstitution of medicine to improve patient safety in hospitals. The aim of this study was to audit the compounding and reconstituting of intravenous medicines on hospital wards in a secondary-care hospital in Finland by using an assessment tool and microbiological testing for identifying issues posing patient safety risks...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220340/validation-of-the-technological-process-of-the-preparation-milk-by-vidal
#13
L P Savchenko, V A Mishchenko, V A Georgiyants
Validation was performed on the technological process of the compounded preparation "Milk by Vidal" in accordance with the requirements of the regulatory framework of Ukraine. Critical stages of formulation which can affect the quality of the finished preparation were considered during the research. The obtained results indicated that the quality of the finished preparation met the requirements of the State Pharmacopoeia of Ukraine.
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#14
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220338/basics-of-compounding-compounding-irrigation-solutions-for-sterile-and-nonsterile-preparations
#15
Loyd V Allen
Compounding pharmacists are sometimes called upon to prepare irrigation solutions, especially in the hospital or clinical setting. Irrigations are indicated for washing or bathing surgical incisions, wounds, and body tissues, including body cavities. Some irrigation solutions coming in contact with exposed tissue, must meet stringent requirements of sterility and bacterial endotoxins. Compounded irrigation solutions may involve wound(s), the bladder, and also may be for ophthalmic, otic, and nasal application...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220337/basics-of-compounding-hot-melt-extrusion
#16
Seth DePasquale
Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production. The use of small-scale extruders and 3D printers provides compounders a pathway for developing new dosage forms at a minimal cost while initial research is being completed. This article discusses the uses of Hot Melt Extrusion, the equipment used, the current and future applications, and the challenges with the technology...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220336/join-the-partnership-for-personalized-prescriptions-p3-advocacy-effort
#17
Cynthia Blankenship
No abstract text is available yet for this article.
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220335/features-of-pharmaceutical-compounding-in-the-republic-of-tajikistan
#18
D S Alfred-Ugbenbo, A H Valiev, O A Zdoryk, V A Georgiyants
Despite the deep assortment of finished pharmaceutical products and the reduction in the number of compounding and hospital pharmacies in the Republic of Tajikistan, the need for extemporal medicinal products is still preserved and remains relevant. This article discusses the practice of compounding in the Republic of Tajikistan. History, laws, limits, regulatory institutions, protocols for compounding pharmacy set up, challenges, equipment, extemporaneous formulations, quality control, and storage within regulatory framework are discussed...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220334/orodispersible-films-for-compounding-pharmacies
#19
Anderson O Ferreira, Marcos Antônio F Brandão, Francisco José Raposo, Hudson C Polonini, Nádia Rezende Barbosa Raposo
Orodispersible film can be defined as a solid pharmaceutical form intended for the delivery and rapid local or systemic release of active ingredients, consisting of a water-soluble polymer film that hydrates rapidly, adhering and dissolving immediately when placed on the tongue or in the oral cavity (oral, palatal, gingival, lingual, or sublingual), without the need for water administration or mastication. Due to its outstanding importance in cases of emergency, practicality of use by patients in transit, and high adherence, orodispersible film has evolved in popularity and success among consumers...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220333/feline-transdermal-formulation-considerations
#20
Lauren Eichstadt Forsythe
Transdermal delivery of drugs is comparatively new in feline patients. However, transdermal formulations can be a desirable option for treating feline patients that are not willing participants to medication administration. However, achieving drug penetration across the skin is not always easy, and there are a wide variety of variables that can further affect penetration. This, coupled with a lack of studies, make transdermal administration an unknown with regards to efficacy and safety for many drugs. This article focuses on drugs that are administered transdermally with the intent of producing systemic effects...
November 2017: International Journal of Pharmaceutical Compounding
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