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Veterinary Journal

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https://www.readbyqxmd.com/read/28392153/malignant-canine-mammary-tumours-preliminary-genomic-insights-using-oligonucleotide-array-comparative-genomic-hybridisation-analysis
#1
Marta Santos, Patrícia Dias-Pereira, Christina Williams, Carlos Lopes, Matthew Breen
Neoplastic mammary disease in female dogs represents a major health concern for dog owners and veterinarians, but the genomic basis of the disease is poorly understood. In this study, we performed high resolution oligonucleotide array comparative genomic hybridisation (oaCGH) to assess genome wide DNA copy number changes in 10 malignant canine mammary tumours from seven female dogs, including multiple tumours collected at one time from each of three female dogs. In all but two tumours, genomic imbalances were detected, with losses being more common than gains...
March 28, 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28392152/how-exercise-influences-equine-joint-homeostasis
#2
REVIEW
Nikae C R Te Moller, P René van Weeren
The maintenance of joint homeostasis is integral to joint health. Knowledge of the influence of exercise on joint homeostasis is not only relevant for determining sustainable levels of equine athletic training, but also for the study of early development of osteoarthritis or cartilage repair in animal models. This review provides an overview of findings derived from in vivo studies and postmortem analyses investigating exercise effects on various joint tissue components in the horse, supplemented where appropriate with data from small animal models...
March 28, 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283369/inertial-sensor-based-system-for-lameness-detection-in-trotting-dogs-with-induced-lameness
#3
M Rhodin, A Bergh, P Gustås, C B Gómez Álvarez
Lameness detection can be challenging in dogs, as reflected in the reported low inter-rater agreement when visually assessing lameness. The aim of this study was to use an inertial sensor-based system to detect and quantify induced distal and proximal limb disturbances mimicking supporting and swinging limb lameness in dogs trotting on a treadmill by measuring vertical head and pelvic movement symmetry. Ten clinically sound dogs were equipped with inertial measurement units that were attached to the head, pelvis and right distal forelimb...
February 10, 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28216233/middle-east-respiratory-syndrome-mers-coronavirus-putting-one-health-principles-into-practice
#4
EDITORIAL
Janet M Daly
No abstract text is available yet for this article.
February 7, 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410676/the-immunoregulatory-effects-of-co-infection-with-fasciola-hepatica-from-bovine-tuberculosis-to-johne-s-disease
#5
REVIEW
Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410675/the-relationship-between-epileptiform-discharges-and-background-activity-in-the-visual-analysis-of-electroencephalographic-examinations-in-dogs-with-seizures-of-different-etiologies
#6
M Wrzosek, J R Ives, M Karczewski, E Dziadkowiak, E Gruszka
Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described and compared. The dogs included neurologically healthy controls (N, n = 19), dogs with portosystemic shunt (PSS, n = 9), dogs with intracranial pathologies (IP, n = 27) and dogs with idiopathic epilepsy (IE, n = 70)...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410674/the-use-of-nosebands-in-equitation-and-the-merits-of-an-international-equestrian-welfare-and-safety-committee-a-commentary
#7
Paul D McGreevy, Orla Doherty, Wayne Channon, Kyra Kyrklund, John Webster
No abstract text is available yet for this article.
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410673/hotspots-of-canine-leptospirosis-in-the-united-states-of-america
#8
Allison M White, Carlos Zambrana-Torrelio, Toph Allen, Melinda K Rostal, Andrea K Wright, Eileen C Ball, Peter Daszak, William B Karesh
Leptospirosis is a widespread zoonotic disease that causes hepatic and renal disease in dogs and human beings. The incidence of leptospirosis in dogs in the USA appears to be increasing. This study used 14 years of canine leptospirosis testing data across 3109 counties in the USA to analyze environmental and socio-economic correlates with rates of infection and to produce a map of locations of increased risk for canine leptospirosis. Boosted regression trees were used to identify the probability of a dog testing positive for leptospirosis based on microscopic agglutination test (MAT) results, and environmental and socio-economic data...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410672/effects-of-sedation-and-salbutamol-administration-on-hyperpnoea-and-tidal-breathing-spirometry-in-healthy-horses
#9
S L Raidal, K Burnheim, D Evans, K J Hughes
Sedation is often required to perform pulmonary function testing (PFT) in horses, but drug effects may influence respiratory function. The current study was designed to characterise the effects of sedation and bronchodilator administration on absolute and relative indices of pulmonary function during eupnoeic respiration and carbon dioxide-induced hyperpnoea (rebreathing) in healthy horses using a pneumotachographic spirometry system. Sedation with acetylpromazine (ACP), xylazine, or both drugs in combination was associated with significant reductions in respiratory frequency, minute ventilation and peak airflows during eupnoeic respiration...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410671/dog-erythrocyte-antigens-dea-1-4-7-and-suspected-naturally-occurring-anti-dea-7-antibodies-in-italian-corso-dogs
#10
E Spada, D Proverbio, V Priolo, D Ippolito, L Baggiani, R Perego, M G Pennisi
We sought to determine the prevalence of dog erythrocyte antigen (DEA) 1, 4 and 7 and naturally occurring anti-DEA7 antibodies in Italian Corso dogs. In addition, we correlated DEAs with different epidemiologic variables, compared the prevalence of DEAs against other canine populations and assessed the risk of sensitisation and transfusion reactions (TRs) following unmatched transfusion. Blood samples from 100 Corso dogs were evaluated for DEA 1, 4, 7 and naturally occurring anti-DEA 7 antibodies. Seventy-one percent of samples were DEA 1-negative, 100% tested DEA 4-positive, and 95% tested DEA 7-negative...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28410670/characterisation-and-intracellular-labelling-of-mesenchymal-stromal-cells-derived-from-synovial-fluid-of-horses-and-sheep
#11
J Burk, S M Glauche, W Brehm, A Crovace, E Francioso, A Hillmann, S Schubert, L Lacitignola
Multipotent mesenchymal stromal cells (MSCs) derived from synovial fluid (SF) are considered to be a promising cell type for therapeutic applications in joint disease. However, despite their potential relevance for clinical and experimental studies, there is insufficient knowledge about SF-derived MSCs isolated from horses and sheep. In this study, cells were recovered from healthy SF and bone marrow (BM) of sheep, and from healthy and osteoarthritic SF of horses. Ovine SF-MSCs were used to assess the efficiency of intracellular labelling with quantum dots (QDs)...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283083/a-novel-model-to-assess-lamellar-signaling-relevant-to-preferential-weight-bearing-in-the-horse
#12
A K Gardner, A W van Eps, M R Watts, T A Burns, J K Belknap
Supporting limb laminitis (SLL) is a devastating sequela to severe unilateral lameness in equine patients. The manifestation of SLL, which usually only affects one limb, is unpredictable and the etiology is unknown. A novel, non-painful preferential weight bearing model designed to mimic the effects of severe unilateral forelimb lameness was developed to assess lamellar signaling events in the supporting limb (SL). A custom v-shaped insert was attached to the shoe of one forelimb to prevent normal weight bearing and redistribute weight onto the SL...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283082/effects-of-the-rider-on-the-kinematics-of-the-equine-spine-under-the-saddle-during-the-trot-using-inertial-measurement-units-methodological-study-and-preliminary-results
#13
P Martin, L Cheze, P Pourcelot, L Desquilbet, L Duray, H Chateau
Many factors associated with the saddle and the rider could produce pain in horses thus reducing performance. However, studies of horse-saddle-rider interactions are limited and determining their effects remains challenging. The aim of this study was to test a novel method for assessing equine thoracic and lumbar spinal movement under the saddle and collect data during trotting. Back movement was measured using inertial measurement units (n = 5) fixed at the levels of thoracic vertebrae T6, T12 and T16, and lumbar vertebrae L2 and L5...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283081/serum-biomarkers-of-oxidative-stress-in-dogs-with-idiopathic-inflammatory-bowel-disease
#14
C P Rubio, S Martínez-Subiela, J Hernández-Ruiz, A Tvarijonaviciute, J J Cerón, K Allenspach
The objective of this work was to study and compare a panel of various serum biomarkers evaluating both the antioxidant response and oxidative damage in dogs with idiopathic inflammatory bowel disease (IBD). Eighteen dogs with IBD and 20 healthy dogs were enrolled in the study. Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine antioxidant response...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283080/correlation-between-severity-of-clinical-signs-and-transcranial-magnetic-motor-evoked-potentials-in-dogs-with-intervertebral-disc-herniation
#15
H-L Amendt, J S Siedenburg, N Steffensen, U Kordass, K Rohn, A Tipold, V M Stein
Transcranial magnetic motor evoked potentials (TMMEPs) can assess the functional integrity of the spinal cord descending motor pathways. In intervertebral disc herniation (IVDH), these pathways are compromised to varying degrees reflected by the severity of neurological deficits. The hypotheses of this study were as follows: (1) TMMEPs differ in dogs with IVDH and healthy control dogs; (2) TMMEPs reflect different severities of neurological signs; and (3) TMMEPs can document functional motor improvement and therefore monitor recovery of function...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283079/molecular-investigation-of-the-direct-anti-tumour-effects-of-nonsteroidal-anti-inflammatory-drugs-in-a-panel-of-canine-cancer-cell-lines
#16
R Yoshitake, K Saeki, M Watanabe, N Nakaoka, S M Ong, M Hanafusa, N Choisunirachon, N Fujita, R Nishimura, T Nakagawa
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been suggested as effective adjunctive anti-tumour agents in human and veterinary medicine. However, the molecular mechanisms associated with their anti-tumour effects and correlations with the expression of cyclooxygenase (COX) and related molecules in tumours remain controversial. The objective of this study was to compare the expression profiles of COX and related molecules with NSAID sensitivity and to explore the molecular mechanisms of anti-tumour effects...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283078/distortion-product-otoacoustic-emissions-in-young-adult-and-geriatric-cats
#17
George M Strain, Kain A McGee
Recordings of distortion product otoacoustic emissions (DPOAEs) were taken from 15 geriatric cats (mean age ± standard deviation, SD, 13.6 ± 2.7 years; range 10.2-19.4 years) and 12 young adult control cats (mean ± SD 4.6 ± 0.5 years; range 3.4-5 years) to identify frequency-specific age-related changes in cochlear responses. Recordings were performed for primary frequencies from 2 to 12 kHz in 2 kHz increments. Cats were considered to be geriatric > 11.9 ± 1.9 years of age...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283077/ground-reaction-forces-of-elite-dressage-horses-in-collected-trot-and-passage
#18
H M Clayton, H C Schamhardt, S J Hobbs
In this study, sagittal plane ground reaction forces (GRFs) in ridden elite dressage horses performing 'collected trot' and in 'passage' over ground were determined. In-ground force plates captured GRF data from four Dutch Warmblood and four Lusitano horses ridden by their trainers. At least three stance phases were analysed for forelimbs and hind limbs per horse. The variables extracted were vertical and longitudinal (braking, propulsive) force maxima, their times of occurrence and the respective impulses for forelimbs and hind limbs...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283076/prevalence-of-thoracic-vertebral-malformations-in-french-bulldogs-pugs-and-english-bulldogs-with-and-without-associated-neurological-deficits
#19
R Ryan, R Gutierrez-Quintana, G Ter Haar, Steven De Decker
Congenital vertebral malformations are common incidental findings in small breed dogs. This retrospective observational study evaluated the type and prevalence of thoracic vertebral malformations in 171 neurologically normal and 10 neurologically abnormal screw-tailed brachycephalic dogs. Neurologically normal dogs underwent CT for reasons unrelated to spinal disease, while affected dogs underwent MRI. Imaging studies were reviewed and vertebral malformations including hemivertebrae, block vertebrae, transitional vertebrae, and spina bifida were documented...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283075/canine-parvovirus-post-vaccination-shedding-interference-with-diagnostic-assays-and-correlation-with-host-immune-status
#20
EDITORIAL
Nicola Decaro, Canio Buonavoglia
No abstract text is available yet for this article.
March 2017: Veterinary Journal
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